High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Renal Denervation in Patients With Heart Failure With Normal LV Ejection Fraction

Conditions:   Heart Failure, Diastolic;   Hypertension
Intervention:   Procedure: Renal denervation + medical therapy
Sponsor:   InCor Heart Institute
Recruiting - verified April 2014

Endothelin Receptor Function and Acute Stress

Condition:   Hypertension
Interventions:   Drug: Bosentan;   Drug: Placebo
Sponsors:   Georgia Regents University;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified April 2014

Triptolide-Containing Formulation as Treatment for Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Condition:   Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Interventions:   Drug: Triptolide-Containing Formulation;   Drug: Placebo
Sponsor:   Shanghai Changzheng Hospital
Recruiting - verified April 2014

Treatment of Atrial Fibrillation in Patients by Pulmonary Vein Isolation, Renal Artery Denervation or Both.

Conditions:   Paroxysmal Atrial Fibrillation;   Persistent Atrial Fibrillation;   Hypertension
Intervention:   Procedure: procedure
Sponsor:   Diagram B.V.
Recruiting - verified April 2014

Extension of the Psychometric Validation Study ORCHESTRA in Patients With PAH

Conditions:   Pulmonary Arterial Hypertension;   PAH
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Not yet recruiting - verified April 2014

Exercise as an Adjunct Therapy to Reduce Blood Pressure in Chronic Kidney Disease

Condition:   Focus Chronic Kidney Disease With Hypertension
Intervention:   Behavioral: Exercise
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified April 2014

Albuterol and Dynamic Hyperinflation in Idiopathic Pulmonary Arterial Hypertension

Condition:   Idiopathic Pulmonary Arterial Hypertension.
Interventions:   Drug: Albuterol.;   Drug: Normal saline placebo
Sponsor:   American Medical Association Foundation
Not yet recruiting - verified April 2014

Assessing Alternative Approaches for Blood Pressure Control: A3BC Trial

Condition:   Hypertension
Interventions:   Device: Device guided breathing RESPeRATE;   Device: Isometric hand grip Zona Plus
Sponsor:   University of Michigan
Not yet recruiting - verified April 2014

Study of a Community Based Approach to Control Cardiovascular Risk Factors in India

Conditions:   Hypertension;   Diabetes;   Smoking;   Cardiovascular Diseases
Intervention:   Behavioral: Community health worker
Sponsor:   University Hospitals of Cleveland
Recruiting - verified April 2014

Evaluation of Pulmonary Perfusion Heterogeneity in Patients With Chronic Thromboembolic Pulmonary Hypertension Using Functional PET Imaging

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Intervention:  
Sponsor:   Massachusetts General Hospital
Recruiting - verified April 2014

Frequency and Clinical Significance of Renal and Bone Toxicity in HIV-infected Patients

Condition:   Renal Toxicity
Intervention:  
Sponsor:   Asociacion para el Estudio de las Enfermedades Infecciosas
Recruiting - verified April 2014

Pupillary Reflex Measurement to Guide Intraoperative Analgesia During Laparoscopic Surgery

Condition:   Scheduled Laparoscopic Surgery
Interventions:   Device: Pupillometry guided analgesia (PP);   Drug: Tailored remifentanil controlled infusion;   Drug: Tailored antihypertensive drug administration
Sponsor:   Central Hospital, Nancy, France
Recruiting - verified April 2014

Comprehensive Lifestyle Modification for Patients With Hypertension and Metabolic Syndrome: a Multicenter Randomized Controlled Trial

Conditions:   Hypertension;   Metabolic Syndrome
Interventions:   Behavioral: Comprehensive Lifestyle Modification;   Behavioral: DASH
Sponsors:   Universität Duisburg-Essen;   Kliniken Essen-Mitte;   Immanuel Hospital Berlin, Berlin, Germany;   Charité University Medical Center, Berlin, Germany;   University of Witten/Herdecke
Recruiting - verified April 2014

Pharmacokinetic Study of OPC-1085EL Ophthalmic Solution in Healthy Male Adult Volunteers

Conditions:   Glaucoma;   Ocular Hypertension
Interventions:   Drug: OPC-1085EL ophthalmic solution;   Drug: Carteolol long-acting ophthalmic solution;   Drug: Latanoprost ophthalmic solution
Sponsor:   Otsuka Pharmaceutical Co., Ltd.
Not yet recruiting - verified April 2014

Comparison of Effect of Postoperative Cyclosporine A 2% Ophthalmic Emulsion and Betamethasone Eye Drop on Surgical Success of Trabeculectomy Procedure

Condition:   Glaucoma, Open Angle
Interventions:   Drug: Cyclosporine;   Drug: Betamethasone
Sponsor:   Mashhad University of Medical Sciences
Recruiting - verified April 2014

A Relative Bioavailability Study of a Fixed Dose Combination (FDC) Tablets of GSK587323

Condition:   Hypertension
Interventions:   Drug: GSK587323;   Drug: FDC of candesartan cilexetil 16 mg and HCTZ 12.5mg
Sponsor:   GlaxoSmithKline
Not yet recruiting - verified March 2014

Gastric Varices Treatment: Coil + Cyanoacrylate Versus Cyanoacrylate

Condition:   Gastric Varices
Interventions:   Device: Treatment: coil + cyanoacrylate;   Device: Treatment: cyanoacrylate
Sponsor:   University of Sao Paulo General Hospital
Recruiting - verified August 2012

Procedure For The Reference Range Study For Absolute MA

Condition:   Transmission, Blood, Recipient/Donor
Intervention:  
Sponsor:   Haemonetics Corporation
Not yet recruiting - verified March 2014

Detecting and Treating High Blood Pressure in Aboriginal Population and Low and Middle Income Countries

Conditions:   Hypertension;   Cardiovascular Disease;   Diabetes
Intervention:   Other: SMS text messaging
Sponsors:   Sunnybrook Health Sciences Centre;   Canadian Institutes of Health Research (CIHR)
Recruiting - verified April 2014

A 28 Day Study of ONO-9054 Ophthalmic Solution in Subjects With Ocular Hypertension (OHT) or Open-angle Glaucoma (OAG)

Conditions:   Ocular Hypertension;   Open Angle-glaucoma
Interventions:   Drug: ONO-9054;   Drug: Latanoprost
Sponsor:   Ono Pharmaceutical Co. Ltd
Not yet recruiting - verified March 2014

Azilsaltan Tablets (Azilva Tablets) Special Drug Use Surveillance "Hypertension Complicated by Diabetes "

Condition:   Hypertension
Intervention:   Drug: Azilsartan
Sponsor:   Takeda
Recruiting - verified April 2014

A Pulmonary Arterial Hypertension Study With Macitentan to Validate the PAH-SYMPACT™ in France, Italy and Spain

Condition:   Pulmonary Arterial Hypertension (PAH)
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Recruiting - verified April 2014

Relative Bioavailability Study of One Amlodipine 10mg Tablet and One Rosuvastatin 20mg Tablet to Two Fixed Dose Combinations of Amlodipine (10mg) and Rosuvastatin (20mg) in Healthy Subjects Under Fasting Conditions

Condition:   Hypertension
Interventions:   Drug: Amlodipine+Rosuvastatin;   Drug: GSK3074477 FDC - 1;   Drug: GSK3074477 FDC - 2
Sponsors:   GlaxoSmithKline;   SingHealth Investigational Medicine Unit, Singapore
Not yet recruiting - verified April 2014

Computed Tomography and Biomarker Analysis in Diagnosing Coronary Artery Disease in Asymptomatic Patients Who Have Undergone Stem Cell Transplant

Conditions:   Cancer Survivor;   Diabetes Mellitus;   Hypertension
Interventions:   Procedure: computed tomography;   Other: cytology specimen collection procedure;   Other: laboratory biomarker analysis;   Other: questionnaire administration
Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI)
Recruiting - verified April 2014

Azilsartan Tablets Special Drug Use Surveillance: Long-term Use

Condition:   Hypertension
Intervention:   Drug: Azilsartan
Sponsor:   Takeda
Active, not recruiting - verified April 2014

Prevention of Postpartum Hemorrhage in Patients With Severe Preeclampsia Using Carbetocin Versus Misoprostol

Condition:   Severe Pre-eclampsia, Postpartum Condition or Complication
Interventions:   Drug: misoprostol;   Drug: carbetocin
Sponsors:   Benha University;   khalid abd aziz mohamed
Recruiting - verified April 2014

Effects of Oral Sildenafil on Mortality in Adults With PAH

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: sildenafil citrate;   Drug: sildenafil citrate;   Drug: sildenafil citrate
Sponsor:   Pfizer
Not yet recruiting - verified April 2014

Monotherapy-Controlled Study of Nifedipine Gastrointestinal Therapeutic System and Candesartan Cilexetil in Combination in Subjects With Essential Hypertension Inadequately Controlled on Candesartan Cilexetil

Condition:   Hypertension
Interventions:   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106);   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106);   Drug: Candesartan Cilexetil;   Drug: Candesartan matching placebo;   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106) 30/16mg matching placebo;   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106)
Sponsor:   Bayer
Not yet recruiting - verified April 2014

Evaluation of 3D Overlay During Transjugular Intrahepatic Portosystemic Shunt (TIPS) Procedure

Condition:   Portal Hypertension
Intervention:   Procedure: TIPS with 3D Overlay
Sponsors:   Medical College of Wisconsin;   Siemens Medical Solutions
Enrolling by invitation - verified April 2014

CKD-346 DDI Study(Telmisartan/S-Amlodipine, Rosuvastatin)

Conditions:   Hypertension;   Hyperlipidemia
Interventions:   Drug: Telmisartan/S-Amlodipine;   Drug: Rosuvastatin;   Drug: Telmisartan/S-Amlodipine + Rosuvastatin;   Drug: Telmisartan/S-Amlodipine + Rosuvastatin
Sponsor:   Chong Kun Dang Pharmaceutical
Completed - verified April 2014

Comparative PK PD Study in PAH Patients (Fox vs. I-Neb)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: lloprost(Ventavis,BAYQ6252, 20 µg/mL);   Drug: lloprost(Ventavis,BAYQ6252, 10 µg/mL)
Sponsor:   Bayer
Recruiting - verified April 2014

iDropper Usability in Glaucoma

Condition:   Glaucoma, Open-Angle [C11.525.381.407]
Intervention:   Device: Open angle glaucoma - iDropper device
Sponsors:   Care Team Solutions;   National Eye Institute (NEI)
Recruiting - verified April 2014

AqueSys XEN 45 Glaucoma Implant in Refractory Glaucoma

Conditions:   Glaucoma;   Glaucoma, Open Angle
Intervention:   Device: AqueSys XEN 45 Glaucoma Implant
Sponsor:   AqueSys, Inc.
Recruiting - verified April 2014

Safety and Efficacy Study for Treatment of Anemia in Newly Initiated Dialysis Patients

Condition:   Anemia of End-stage Renal Disease
Interventions:   Drug: FG-4592;   Drug: Epoetin Alfa
Sponsors:   FibroGen;   Astellas Pharma Europe B.V.;   AstraZeneca
Recruiting - verified April 2014

MERIT-1: Macitentan in thE tReatment of Inoperable Chronic Thromboembolic Pulmonary Hypertension

Condition:   Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Interventions:   Drug: Macitentan;   Drug: Placebo
Sponsor:   Actelion
Recruiting - verified April 2014

Randomized Trial Comparing Diltiazem and Metoprolol For Atrial Fibrillation Rate Control

Conditions:   Atrial Fibrillation;   Atrial Flutter
Interventions:   Drug: Metoprolol;   Drug: Diltiazem
Sponsor:   CAMC Health System
Recruiting - verified April 2014

Add-on to Micamlo BP Trial

Condition:   Hypertension
Interventions:   Drug: Telmisartan + amlodipine;   Drug: hydrochlorothiazide;   Drug: Telmisartan + amlodipine;   Drug: Placebo
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2014

Take Charge of Your Diabetes

Conditions:   Diabetes;   Hypertension
Intervention:   Behavioral: Financial Incentive: Fixed Lottery
Sponsors:   University of Pennsylvania;   National Institute on Aging (NIA)
Active, not recruiting - verified April 2014

Evaluation of Blood Pressure Reduction, Safety, and Tolerability of Canagliflozin in Patients With Hypertension and Type 2 Diabetes Mellitus on Stable Doses of Anti-hyperglycemic and Anti-hypertensive Agents

Conditions:   Diabetes Mellitus, Type 2;   Hypertension
Interventions:   Drug: Canagliflozin;   Drug: Placebo
Sponsor:   Janssen Scientific Affairs, LLC
Recruiting - verified April 2014

GLORIA-AF Registry Program (Phase II/III)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2014

Functional and Structural Imaging for Glaucoma

Condition:   Glaucoma
Intervention:  
Sponsors:   Oregon Health and Science University;   National Eye Institute (NEI)
Recruiting - verified April 2014

Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction

Conditions:   Heart Disease;   Heart Failure With Preserved Ejection Fraction;   Exercise Intolerance;   Pulmonary Hypertension
Interventions:   Drug: Nitrite;   Drug: Saline Placebo for Nitrite
Sponsors:   Mayo Clinic;   Barry Borlaug
Recruiting - verified April 2014

Sleep Apnea in Type 1 Diabetes

Condition:   Type 1 Diabetes, Sleep Apnea Syndrome
Interventions:   Other: Polysomnography;   Other: Evaluation of the autonomous nervous system;   Other: Clinical examination of the sleep;   Other: Clinical examination of diabetology;   Other: Biological dosages;   Other: Electrocardiogram (ECG);   Other: Carotid echography;   Other: Blood pressure
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Ministry of Health, France
Recruiting - verified April 2014

Eye Pressure Lowering Surgery

Condition:   Glaucoma
Intervention:  
Sponsor:   Oregon Health and Science University
Recruiting - verified April 2014

The Measurement of Intraocular Pressure in Normal Children Under General Anesthesia With and Without Nitrous Oxide and Anesthetic Eye Drops

Conditions:   Glaucoma;   Intraocular Pressure;   Anesthesia
Intervention:   Drug: Tono-pen XL Applanation tonometer + Ocu-film +
Sponsor:   University of Miami
Recruiting - verified April 2014

Resynchronisation Therapy of Right Ventricle in Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Procedure: Resynchronization therapy of right ventricle
Sponsor:   University Hospital, Caen
Recruiting - verified April 2014

Relaxin in Multiple Sclerosis (MS)

Condition:   Multiple Sclerosis, Relapsing-Remitting
Interventions:   Procedure: Blood Draw;   Procedure: Lumbar Puncture
Sponsors:   Providence Health & Services;   Providence Brain & Spine Institute
Recruiting - verified April 2014

Quantifying the Presence of Lung Disease and Pulmonary Hypertension in Children With Sickle Cell Disease

Condition:   Sickle Cell Disease
Intervention:   Drug: Albuterol
Sponsor:   Duke University
Recruiting - verified March 2014

Sildenafil Therapy For Subjects Who Derive Clinical Benefit From Continued Treatment With Sildenafil

Condition:   Pulmonary Arterial Hypertension (PAH)
Intervention:   Drug: sildenafil
Sponsor:   Pfizer
Available - verified April 2014

A Open Label Study to Assess the Long-term Safety, Tolerability and Efficacy of Ambrisentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Condition:   Hypertension
Intervention:   Drug: Ambrisentan 5 mg
Sponsor:   GlaxoSmithKline
Recruiting - verified April 2014

Ambrisentan for Inoperable Chronic Thromboembolic Pulmonary Hypertension.

Condition:   Hypertension
Interventions:   Drug: Ambrisentan 5 mg;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Recruiting - verified April 2014

Efficacy and Safety of LCZ696 Compared to Olmesartan in Essential Hypertensive Patients Not Responsive to Olmesartan

Condition:   Hypertension
Interventions:   Drug: LCZ696;   Drug: Olmesartan;   Drug: Placebo of LCZ696;   Drug: Placebo of Olmesartan
Sponsors:   Novartis;   Novartis Pharmaceuticals
Recruiting - verified April 2014

Phase 1, Randomized, Double-Blind, Placebo-Controlled Exploratory Study That Will Assess the Safety, Tolerability, Pharmacokinetics and Hemodynamic Response to a Single 30 Minute Intravenous Infusion of Vasomera™ (PB1046) in Adult Subjects With Stage 1 or 2 Essential Hypertension

Condition:   Essential Hypertension
Interventions:   Drug: Placebo Single IV (Intravenous) Infusion;   Drug: Experimental: Single IV Infusion Vasomera (PB1046)
Sponsor:   PhaseBio Pharmaceuticals Inc.
Completed - verified April 2014

A Study to Evaluate the Effect of LCZ696 on Aortic Stiffness in Subjects With Hypertension

Condition:   Hypertension
Interventions:   Drug: LCZ696;   Drug: olmesartan;   Other: placebo to LCZ696;   Other: placebo to olmesartan
Sponsors:   Novartis;   Novartis Pharmaceuticals
Recruiting - verified April 2014

Standard 24-hour Urine Protein vs Shorter Period for Diagnosis of Pre-eclampsia

Condition:   Preeclampsia
Intervention:  
Sponsor:   HaEmek Medical Center, Israel
Not yet recruiting - verified June 2013

Abiraterone With Different Steroid Regimens for Side Effect Related to Mineralcorticoid Excess Prevention in Prostate Cancer Prior to Chemotherapy

Condition:   Prostate Cancer
Interventions:   Drug: Abiraterone Acetate;   Drug: Prednisone 5 mg twice daily;   Drug: Prednisone 5 mg once daily;   Drug: Prednisone 2.5 mg twice daily;   Drug: Dexamethasone 0.5 mg once daily
Sponsor:   Janssen Pharmaceutica N.V., Belgium
Recruiting - verified April 2014

AC-055-402: An Extension of AC-055-401, Study of Macitentan in Patients With PAH to Psychometrically Validate PAH-SYMPACT Instrument

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Completed - verified April 2014

Efficacy and Safety Study of Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide Combination Therapy in Patients With Hypertension Not Controlled With Olmesartan Medoxomil and Hydrochlorothiazide Combination Therapy

Condition:   Essential Hypertension
Interventions:   Drug: CS8635 20/5/12.5mg and placebo;   Drug: Olmetec® Plus 20/12.5mg and placebo
Sponsor:   Daiichi Sankyo Korea Co., Ltd.
Recruiting - verified April 2014

New Magnesium Sulphate Protocol for Pre-eclampsia

Condition:   Pre-eclampsia
Intervention:   Drug: MgSO4
Sponsor:   Cairo University
Completed - verified April 2014

Treatment of Hypertensive Leg Ulcer by Adipose Tissue Grafting

Condition:   Skin Ulcer
Intervention:   Procedure: adipose tissue grafting
Sponsor:   University Hospital, Caen
Recruiting - verified April 2014

SYMPHONY: A Study of Macitentan in Pulmonary Arterial Hypertension to Validate the PAH-SYMPACT

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Recruiting - verified April 2014

Proton w/FOLFIRINOX-Losartan for Pancreatic Cancer

Condition:   Pancreatic Cancer
Interventions:   Drug: FOLFIRINOX;   Drug: Losartan;   Radiation: Proton Beam Radiation
Sponsors:   Massachusetts General Hospital;   National Cancer Institute (NCI)
Recruiting - verified April 2014

Sleep to Lower Elevated Blood Pressure

Conditions:   Hypertension;   Sleep Disorders;   Insomnia;   Cardiovascular Diseases
Intervention:   Behavioral: Online Sleep Education
Sponsors:   University College Hospital Galway;   Health Research Board, Ireland
Recruiting - verified April 2014

Effects of Linagliptin on Renal Endothelium Function in Patients With Type 2 Diabetes.

Condition:   Type 2-diabetes
Interventions:   Drug: Linagliptin;   Drug: Placebo
Sponsor:   University of Erlangen-Nürnberg Medical School
Completed - verified April 2014

Calcium Supplementation to Prevent Preeclampsia in Sichuan Province of China

Condition:   Preeclampsia
Intervention:   Drug: calcium
Sponsors:   West China Second University Hospital;   Sichuan Academy of Medical Sciences;   people's hospital of Guang'an;   pengzhou shi fuyou baojianyuan;   The first people's hospital of Neijiang;   Suining Central Hospital;   Sichuan Provincial Maternal and Child Health Care Hospital;   Chengdu Women's and Children's Central Hospital
Recruiting - verified April 2014

Prediction of Adverse Perinatal Outcome for Preeclampsia in Sichuan Province of China

Condition:   Preeclampsia
Intervention:  
Sponsors:   West China Second University Hospital;   Sichuan Academy of Medical Sciences;   people's hospital of Guang'an;   The first people's hospital of Neijiang;   Suining Central Hospital;   Sichuan Provincial Maternal and Child Health Care Hospital;   Chengdu Women's and Children's Central Hospital;   THE AFFILIATED HOSPITAL OF LUZHOU MEDICAL COLLEGE;   pengzhou shi fuyou baojianyuan;   NANCHONG CENTRAL HOSPITAL
Not yet recruiting - verified June 2013

Intranasal Insulin: A Novel Treatment for Gulf War Multisymptom Illness

Condition:   Chronic Multisymptom Illness in Gulf War Veterans
Intervention:   Device: Intranasal Insulin
Sponsors:   Bronx Veterans Medical Research Foundation, Inc;   VA Boston Healthcare System;   Boston University
Not yet recruiting - verified April 2014

Riociguat in Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Adempas (Riociguat, BAY63-2521)
Sponsor:   Bayer
Available - verified April 2014

A Non-Interventional Follow Up Study For Subjects Who Received Sildenafil for Persistent Pulmonary Hypertension of the Newborn (PPHN)

Condition:   Pulmonary Hypertension, Persistent, of the Newborn
Intervention:   Other: non-interventional
Sponsor:   Pfizer
Completed - verified April 2014

Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma

Condition:   Hemangioma
Interventions:   Drug: Acebutolol;   Drug: Propanolol
Sponsor:   University Hospital, Montpellier
Recruiting - verified April 2014

MAESTRO (Macitentan in Eisenmenger Syndrome To Restore Exercise Capacity)

Condition:   Eisenmenger Syndrome
Interventions:   Drug: Macitentan 10 mg, oral tablet, to be taken once daily.;   Drug: Matching placebo oral tablet, to be taken once daily.
Sponsor:   Actelion
Recruiting - verified April 2014

Long-term Study of AIR001 in Subjects With WHO Group 1 Pulmonary Arterial Hypertension Who Completed AIR001-CS05

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: AIR001
Sponsor:   Aires Pharmaceuticals, Inc.
Terminated - verified April 2014

A Phase 2 Study to Determine the Safety and Efficacy of AIR001 in Subjects With Pulmonary Arterial Hypertension (PAH)

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: AIR001 (sodium nitrite inhalation solution)
Sponsor:   Aires Pharmaceuticals, Inc.
Terminated - verified April 2014

A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn

Condition:   Pulmonary Hypertension, Familial Persistent, of the Newborn
Interventions:   Drug: placebo;   Drug: iv sildenafil
Sponsor:   Pfizer
Recruiting - verified April 2014

The Hemodynamic Effects During Sustained Low-efficiency Dialysis Versus Continuous Veno-venous Hemofiltration for Patients With Intracranial Hypertension in a Cross Over Study

Condition:   End- Stage Renal Disease Patients
Intervention:   Procedure: hemodialysis
Sponsor:   National Taiwan University Hospital
Withdrawn - verified April 2014

Effect of an Apple Polyphenol Extract on Brachial Artery Flow-mediated Vasodilatory Function

Condition:   Borderline Hypertension
Interventions:   Dietary Supplement: Epicatechin;   Dietary Supplement: Microcrystalline cellulose
Sponsors:   Danisco;   University of Turku;   4Pharma Ltd.
Completed - verified April 2014

A Pilot Study of Plasma Renin Activity Guided vs Generic Combination Therapy for Hypertension

Conditions:   Hypertension;   Plasma Renin Activity
Interventions:   Drug: Hydrochlorothiazide;   Drug: Lisinopril;   Drug: Amlodipine;   Drug: metoprolol;   Drug: lisinopril/hydrochlorothiazide
Sponsors:   University of North Carolina, Chapel Hill;   Cornell University;   Wake Forest School of Medicine
Active, not recruiting - verified April 2014

Renal Denervation by MDT-2211 System in Patients With Uncontrolled Hypertension

Condition:   Uncontrolled Hypertension
Intervention:   Device: MDT-2211 Renal Denervation System
Sponsor:   Medtronic Vascular
Active, not recruiting - verified April 2014

Safety And Efficacy Of Sildenafil In Children With Pulmonary Arterial Hypertension

Conditions:   Pulmonary Arterial Hypertension;   Hypertension, Pulmonary
Intervention:   Drug: Sildenafil
Sponsor:   Pfizer
Recruiting - verified April 2014

Randomized, Double-Blind, Safety and Efficacy Study of RE-021 (Sparsentan) in Focal Segmental Glomerulosclerosis

Condition:   Focal Segmental Glomerulosclerosis
Interventions:   Drug: RE-021 (Sparsentan);   Drug: Irbesartan
Sponsor:   Retrophin, Inc.
Recruiting - verified April 2014

Using Optical Coherence Tomography to Capture Retinal Microvascular Changes Associated With Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:  
Sponsor:   Oregon Health and Science University
Recruiting - verified April 2014

An Open Label Access Study For Subjects Who Completed A1481156

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Access program
Sponsor:   Pfizer
Temporarily not available - verified April 2014

An Open-Label, Long-Term Study of Oral Treprostinil in Subjects With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: UT-15C (treprostinil diethanolamine)
Sponsor:   United Therapeutics
Recruiting - verified April 2014

Trial of the Early Combination of Oral Treprostinil With a PDE-5 Inhibitor or ERA in Subjects With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: UT-15C (treprostinil diethanolamine);   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting - verified April 2014

Effectiveness of Vyvanse Compared to Concerta in Adolescents With Attention-deficit/Hyperactivity Disorder

Condition:   Attention-deficit/Hyperactivity Disorder
Interventions:   Drug: Lisdexamfetamine dimesylate;   Drug: Methylphenidate Hydrochloride;   Drug: Placebo
Sponsor:   Shire
Active, not recruiting - verified April 2014

New Markers to Measure Clotting in Patients With the Obstructive Sleep Apnoea Hypopnoea Syndrome

Conditions:   Obstructive Sleep Apnoea Hypopnoea Syndrome;   Biomarkers of Fibrin Clot Structure;   Biomarkers of Vascular Endothelial Injury
Intervention:  
Sponsors:   Hywel Dda Health Board;   National Institute for Health Research, United Kingdom;   Abertawe Bro Morgannwg University NHS Trust;   Swansea University
Completed - verified April 2014

Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension

Condition:   Orthostatic Hypotension
Interventions:   Drug: Midodrine HCl;   Drug: Placebo
Sponsor:   Shire
Completed - verified April 2014

Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension

Condition:   Symptomatic Orthostatic Hypotension
Interventions:   Drug: Midodrine HCl;   Drug: Placebo
Sponsor:   Shire
Completed - verified April 2014

Revatio Portal-Pulmonary Arterial Hypertension Trial

Condition:   Portopulmonary Hypertension
Interventions:   Drug: Sildenafil;   Drug: Placebo
Sponsor:   University Health Network, Toronto
Enrolling by invitation - verified April 2014

A Pharmacokinetics Study for Pediatric Participants With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Tadalafil- Tablet
Sponsor:   Eli Lilly and Company
Recruiting - verified April 2014

Comparison of the Ahmed Glaucoma Valve FP7 and FP8 in Pediatric Glaucoma

Condition:   Pediatric Glaucoma
Interventions:   Device: FP7 Ahmed Glaucoma Drainage Implant;   Device: FP8 Glaucoma Drainage Implant
Sponsor:   Federal University of São Paulo
Recruiting - verified April 2014

Effectiveness of Adalimumab in Moderate to Severe Plaque Psoriasis Patients With Distinct Co-morbidities

Conditions:   Moderate to Severe Plaque Psoriasis;   Antibodies;   Monoclonals
Intervention:  
Sponsors:   AbbVie;   AbbVie (prior sponsor, Abbott);   Mag. Andreas Raffeiner GMBH
Recruiting - verified April 2014

Effect of a Low Advanced Glycation End Products (AGE) Diet in the Metabolic Syndrome

Condition:   Metabolic Syndrome
Interventions:   Other: Regular AGE Diet;   Other: Low AGE Diet
Sponsors:   Mount Sinai School of Medicine;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting - verified April 2014

Post-marketing Surveillance for Hypertensive Patients With Diabetes and/or Chronic Kidney Disease

Condition:   Hypertension
Intervention:   Drug: Nifedipine (Adalat CR, BAYA1040)
Sponsor:   Bayer
Completed - verified April 2014

Physical Fitness, Cardiovascular and Brain Health

Condition:   Hypertension
Interventions:   Behavioral: Aerobic Exercise;   Behavioral: Relaxation
Sponsors:   University of Texas at Austin;   American Federation for Aging Research
Completed - verified April 2014

Febuxostat, Blood Pressure and the Intrarenal Renin-Angiotensin System (RAS)

Condition:   Hypertension
Intervention:   Drug: Febuxostat
Sponsor:   University of Utah
Completed - verified February 2014

A New Translational Tool for Studying the Role of Breathing in Meditation

Condition:   Hypertension
Interventions:   Behavioral: Mindful Breathing (MB) Intervention;   Behavioral: Usual Care (UC) Control Condition
Sponsors:   University of California, San Francisco;   National Center for Complementary and Alternative Medicine (NCCAM)
Recruiting - verified April 2014

High Cardiovascular Risk Management and Salt Reduction in Rural Villages in China

Condition:   Cardiovascular Disease
Interventions:   Behavioral: High-risk patient standardized management package;   Behavioral: Community based salt reduction program
Sponsors:   The George Institute for Global Health, China;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified April 2014

Effect of Bosentan in Scleroderma Renal Crisis

Condition:   Scleroderma Renal Crisis
Intervention:   Drug: Bosentan
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Actelion
Recruiting - verified April 2014

Bosutinib For Autosomal Dominant Polycystic Kidney Disease

Condition:   Polycystic Kidney, Autosomal Dominant
Interventions:   Drug: Bosutinib;   Drug: Bosutinib;   Drug: Placebo
Sponsor:   Pfizer
Active, not recruiting - verified April 2014

Metabolic Impact of Fructose Restriction in Obese Children

Conditions:   Obesity;   Metabolic Syndrome
Intervention:   Other: fructose restriction diet
Sponsors:   University of California, San Francisco;   Touro University
Recruiting - verified April 2014

Double-blind, Randomized Placebo-controlled Trial of Carvedilol for Early Primary Prophylaxis of Esophageal Varices

Condition:   Cirrhosis
Interventions:   Drug: Carvedilol;   Drug: Placebo
Sponsor:   Institute of Liver and Biliary Sciences, India
Completed - verified December 2013

Safety and Efficacy of Aliskiren in Pediatric Hypertensive Patients 6-17 Years of Age

Condition:   Hypertension
Interventions:   Drug: Aliskiren;   Drug: Aliskiren;   Drug: Aliskiren
Sponsors:   Novartis;   Novartis Pharmaceuticals
Recruiting - verified April 2014

Controlling Hypertension Outcomes by Improved Communication & Engagement

Conditions:   Hypertension;   Stroke
Intervention:   Behavioral: Four Habits Model
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Pragmatic RCT Comparing Aripiprazole, Olanzapine and Haloperidol in the Treatment of Schizophrenia

Condition:   Schizophrenia
Interventions:   Drug: Aripiprazole;   Drug: Olanzapine;   Drug: Haloperidol
Sponsors:   Mario Negri Institute for Pharmacological Research;   Bristol-Myers Squibb
Completed - verified April 2014

Dose Adjusting Enoxaparin Thromboprophylaxis Dosage According to Anti-factor Xa Plasma Levels Improve Pregnancy Outcome

Conditions:   Fetal Demise;   Fetal Growth Restriction;   Preeclampsia;   Abruptio Placentae;   Thromboembolism
Intervention:   Drug: enoxaparin
Sponsor:   HaEmek Medical Center, Israel
Recruiting - verified March 2013

Care Transitions for Complex Patient - Cycle 1 and Cycle 2

Conditions:   Asthma;   Coronary Artery Disease;   Diabetes;   Hypertension;   Congestive Heart Failure
Interventions:   Other: Reports;   Other: Reports and Notices;   Other: Usual care
Sponsors:   Duke University;   Northern Piedmont Carolina Community Care Partners;   North Carolina Division of Medical Assistance
Completed - verified February 2014

Study Comparing Two Tapering Strategies of Prednisone in Myasthenia Gravis

Condition:   Myasthenia Gravis
Intervention:   Drug: Prednisone - Azathioprine
Sponsor:   Assistance Publique - Hôpitaux de Paris
Active, not recruiting - verified June 2012

High Blood Pressure and Sleep Apnea in Diabetic Macular Edema

Condition:   Diabetic Retinopathy
Interventions:   Behavioral: high blood pressure treatment;   Behavioral: sleep apnea treatment;   Behavioral: diabetic macular edema treatment
Sponsor:   Assistance Publique - Hôpitaux de Paris
Completed - verified April 2014

Action in Diabetes and Vascular Disease Preterax and Diamicron MR Controlled Evaluation Post Trial Observational Study

Condition:   Diabetes Mellitus, Type 2
Intervention:  
Sponsors:   The George Institute;   Servier
Completed - verified April 2014

Trabeculectomy With Mitomycin C Associated With Sub-conjunctival Injection of Ranibizumab

Condition:   Glaucoma
Interventions:   Drug: ranibizumab;   Procedure: standard care
Sponsors:   Maisonneuve-Rosemont Hospital;   Novartis
Completed - verified April 2014

Open Label Access Study Of Sildenafil In Adult Patients With Pulmonary Arterial Hypertension Completing A1481244 Study

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Sildenafil citrate
Sponsor:   Pfizer
Temporarily not available - verified April 2014

Trial of Low and High Intensity Strategies to Maintain BP Control

Condition:   Hypertension
Interventions:   Other: High Intensity Intervention;   Other: Low Intensity Intervention;   Other: All- 6 month pharmacist intervention
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Special Investigation For Long-Term Use Of Sildenafil (Regulatory Post Marketing Commitment Plan)

Condition:   Pulmonary Hypertension
Intervention:   Drug: SILDENAFIL
Sponsor:   Pfizer
Enrolling by invitation - verified April 2014

Working With Veterans Organizations to Improve Blood Pressure

Condition:   Hypertension
Interventions:   Behavioral: Peer support meetings;   Behavioral: Educational presentations
Sponsors:   Department of Veterans Affairs;   Medical College of Wisconsin;   Veterans of Foreign Wars;   Vietnam Veterans of America;   National Association of Black Veterans;   Korean War Veterans of America;   Disabled American Veterans;   AmVETS;   Jewish War Veterans of the U.S.A.;   American Legion Department of Wisconsin;   Wisconsin Elks Association
Completed - verified April 2014

Pharmacist-led Group Medical Visits to Help With Diabetes Management

Conditions:   Diabetes Mellitus;   Cardiovascular Diseases
Interventions:   Other: Algorithm driven medication titration;   Behavioral: Monitoring;   Behavioral: Group support;   Behavioral: Self efficacy
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Family-supported Smoking Cessation for Chronically Ill Veterans

Conditions:   Chronic Disease;   Neoplasm;   Cardiovascular Disease;   Pulmonary Disease, Chronic Obstructive;   Diabetes Mellitus;   Hypertension
Interventions:   Behavioral: Family-supported;   Behavioral: Standard Telephone counseling
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Strategies to Maintain Cardiac Risk Control After Discharge From Cardiovascular Risk Reduction Clinic

Conditions:   Diabetes;   Dyslipidemia;   Hypertension;   Coronary Atherosclerosis
Interventions:   Behavioral: Counseling;   Behavioral: Interactive Education;   Behavioral: Group Support;   Procedure: Pharmacologic case management
Sponsors:   Providence VA Medical Center;   Merck Sharp & Dohme Corp.
Completed - verified April 2014

Financial Incentives to Translate ALLHAT Into Practice: A Randomized Trial

Condition:   Hypertension
Interventions:   Behavioral: Physician-level financial incentive;   Behavioral: Group-level financial incentive;   Behavioral: Physician and group-level financial incentives
Sponsors:   Department of Veterans Affairs;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2014

Can Group Visits Improve Outcomes of Veterans With Diabetes

Conditions:   Diabetes;   Hypertension
Intervention:   Other: Diabetes Group Management Visits
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia

Conditions:   Sickle Cell Disease;   Chronic Kidney Disease;   Pulmonary Hypertension
Intervention:   Drug: Erythropoietin and Hydroxyurea
Sponsors:   National Institutes of Health Clinical Center (CC);   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified March 2014

Improving Practice Patterns for the Treatment of Hypertension

Condition:   Hypertension
Interventions:   Behavioral: Provider Education;   Behavioral: Hypertension Alert;   Behavioral: Patient Education
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Frequent Hemodialysis Network: Daily Trial

Conditions:   End Stage Renal Disease;   Hemodialysis
Intervention:   Behavioral: Frequent hemodialysis
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed - verified April 2014

3-D Transcranial Ultrasound Analysis Study

Conditions:   Cerebrovascular Accident;   Intracranial Hypertension
Interventions:   Device: 3-D ultrasound scanner;   Drug: Perflutren Protein-Type A Microspheres for injection
Sponsor:   Duke University
Completed - verified April 2014

Hypertension Intervention Nurse Telemedicine Study (HINTS)

Condition:   Hypertension
Interventions:   Behavioral: Nurse Behavioral intervention with Home BP Telemonitoring;   Behavioral: Nurse Medication Management with Home BP Telemonitoring;   Behavioral: Nurse Combined intervention with Home BP Telemonitoring
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

The Effect of Nebivolol on Insulin Sensitivity

Condition:   Hypertension
Interventions:   Drug: Nebivolol;   Drug: Atenolol
Sponsors:   Imperial College London;   Foundation for Circulatory Health
Completed - verified April 2014

Guidelines for Drug Therapy of Hypertension: Multi-Site Implementation

Condition:   Hypertension
Interventions:   Behavioral: ATHENA Decision Support System, An Automated Clinical Decision Support System for Health Care Providers;   Behavioral: Profiling performance
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Novel Approaches in Linkage Analysis for Complex Traits

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Hypertension
Intervention:  
Sponsors:   Mayo Clinic;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2014

Effectiveness and Cost Impact of a Telecommunications System in COPD

Condition:   Lung Diseases, Obstructive
Intervention:   Procedure: Telephone Monitoring
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

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