High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Evaluating Effective Methods for Referral for Smoking Cessation Counseling and High Blood Pressure Follow-up

Conditions:   Hypertension;   Smoking Cessation
Interventions:   Behavioral: Referral to primary care physician for hypertension control;   Behavioral: Referral to smoking quit line
Sponsor:   Johns Hopkins University
Completed - verified January 2017

Specific Use-result Surveillance of T80/A5/H12.5 FDC in Hypertension

Condition:   Hypertension
Intervention:  
Sponsor:   Boehringer Ingelheim
Not yet recruiting - verified January 2017

The Prophet Trial - Pilot Study to Assess Safety and Efficacy of a Novel Atrial Flow Regulator (AFR) in Patients With Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Device: Occlutech AFR Device
Sponsor:   Occlutech International AB
Not yet recruiting - verified January 2017

Hypertension In Postpartum Preeclampsia Study

Condition:   Hypertension, Pregnancy-Induced
Interventions:   Drug: Acetaminophen;   Drug: Ibuprofen
Sponsor:   MemorialCare Health System
Recruiting - verified January 2017

Retrospective Evaluation of Athens Complete Health Improvement Program (CHIP) Database

Conditions:   Cardiovascular Diseases;   Diabetes Mellitus;   Hypertension;   Dyslipidemias;   Overweight and Obesity
Intervention:   Behavioral: The Complete Health Improvement Program
Sponsor:   Ohio University
Completed - verified January 2017

Clinical Calibration & Validation of a Next-Generation Blood Pressure Monitor for Patient Management

Condition:   Hypertension
Intervention:  
Sponsors:   Cardiovascular Research New Brunswick;   New Brunswick Health Research Foundation (NBHRF);   Health + Life Sciences New Brunswick, Incorporated (HLSNB);   Cloud Diagnostics, Incorporated;   Horizon Health Network
Active, not recruiting - verified January 2017

Individualizing Disease Prevention for Middle-Aged Adults

Condition:   Primary Health Care
Intervention:  
Sponsor:   Glen Taksler
Not yet recruiting - verified January 2017

Influence of Age, Weight and Ethnic Background on Blood Pressure

Conditions:   Cardiovascular Diseases;   Vascular Diseases;   Hypertension
Interventions:   Other: Brief lifestyle/medical history questionnaire;   Other: Anthropometric measures;   Other: Blood pressure and arterial stiffness;   Other: Cardiac output and lung function;   Other: Heart rate variability;   Other: Blood sample & spot urine sample;   Other: 24 hour ambulatory blood pressure monitor;   Other: 24 hour urine collection;   Other: Echocardiograph: Left ventricular mass;   Other: Large artery structure: Carotid intima-media thickness;   Other: Small artery structure: Minimum forearm vascular resistance;   Other: Large artery endothelial function;   Other: Small artery endothelial function: Forearm blood flow;   Other: Dundee step test;   Other: Detailed haemodynamic response to submaximal exercise;   Other: Cardiopulmonary fitness: Maximum oxygen consumption;   Other: Haemodynamic response to mental stress
Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   University of Cambridge
Not yet recruiting - verified January 2017

Pharmacokinetic Drug-drug Interaction of CKD-330 and D086

Conditions:   Hypertension;   Hyperlipidemias
Interventions:   Drug: CKD-330;   Drug: D086;   Drug: CKD-330 + D086
Sponsor:   Chong Kun Dang Pharmaceutical
Recruiting - verified January 2017

Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease

Condition:   Endstage Renal Disease
Interventions:   Drug: Spironolactone 25Mg Tablet;   Drug: Placebo Oral Tablet
Sponsors:   Population Health Research Institute;   Canadian Institutes of Health Research (CIHR)
Not yet recruiting - verified January 2017

Exploring Time-efficient Strategies to Improve Fitness for Surgery in Older Adults

Conditions:   Perioperative Hypertension;   Hypertension
Interventions:   Other: HIIT;   Other: HOLD;   Other: HUG
Sponsors:   University of Nottingham;   The Royal College of Surgeons of England;   The Dunhill Medical Trust
Recruiting - verified January 2017

Inflammation, Diabetes, Ethnicity and Obesity Cohort

Conditions:   Obesity;   Diabetes Mellitus
Intervention:  
Sponsors:   University of California, San Francisco;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 2017

Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients

Condition:   Primary Hypertension
Interventions:   Drug: Intensive BP control;   Drug: Standard BP control
Sponsor:   Chinese Academy of Medical Sciences, Fuwai Hospital
Recruiting - verified January 2017

Berberine, Chlorogenic Acid and Tocotrienols in Menopause-associated Dyslipidemia

Condition:   Dyslipidemia
Interventions:   Dietary Supplement: Nutraceutical;   Other: Control
Sponsors:   IRCCS Policlinico S. Matteo;   University of Pavia
Not yet recruiting - verified January 2017

Optimization of Blood Pressure Management After Acute Ischemic Stroke and Its Prognostic Significance

Conditions:   Ischemic Stroke;   Hypertension
Interventions:   Behavioral: Behavioral intensification;   Drug: Pharmacological intensification based on olmesartan;   Device: Bluetooth-equipped sphygmomanometer
Sponsors:   Seoul National University Bundang Hospital;   Daiichi Sankyo Korea Co., Ltd.
Recruiting - verified January 2017

Efficacity and Safety of Tranexamic Acid in Cirrhotic Patients Presenting With Acute Upper Gastrointestinal Bleeding

Conditions:   Upper Digestive Bleeding;   Cirrhosis;   Portal Hypertension
Interventions:   Drug: Tranexamic acid;   Drug: Placebo
Sponsor:   Assistance Publique - Hôpitaux de Paris
Not yet recruiting - verified December 2016

Registry of IgA Nephropathy in Chinese Children

Conditions:   IgA Nephropathy;   Proteinuria in Nephrotic Range;   Immunosuppressive Treatment
Interventions:   Drug: Corticosteroid;   Drug: Cyclophosphamide;   Drug: Mycophenolate mofetil;   Drug: Dipyridamole;   Drug: ACE Inhibitor or Angiotensin receptor antagonist
Sponsors:   Peking University First Hospital;   Nanjing PLA General Hospital;   Beijing Children's Hospital;   Central South University;   The Children's Hospital of Zhejiang University School of Medicine;   First Affiliated Hospital, Sun Yat-Sen University;   Tongji Hospital;   Hunan Children's Hospital;   Shanghai Children's Hospital;   Nanjing Children's Hospital;   Children's Hospital of Chongqing Medical University;   Shandong Provincial Hospital;   Fuzhou General Hospital;   Second Affiliated Hospital of Wenzhou Medical University;   Children's Hospital of Hebei Province;   Guangzhou Women and Children's Medical Center;   Jiangxi Province Children's Hospital;   Guangzhou First Municipal People’s Hospital;   Xi'an Children's Hospital;   Capital Institute of Pediatrics, China;   First Hospital of Jilin University;   Wuhan Women and Children's Medical Center;   Tianjin Children's Hospital;   Chengdu Women's and Children's Central Hospital;   The First People's Hospital of Yunnan
Recruiting - verified January 2017

Stanford Healthy Heart Study

Condition:   Obesity
Interventions:   Behavioral: Fun First;   Behavioral: Weight Watchers
Sponsors:   Stanford University;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified January 2017

Pragmatic Trial Comparing Telehealth Care and Optimized Clinic-Based Care for Uncontrolled High Blood Pressure

Condition:   Hypertension
Interventions:   Other: Best Practice Clinic-Based Care;   Other: Telehealth Care
Sponsors:   HealthPartners Institute;   Patient-Centered Outcomes Research Institute
Not yet recruiting - verified December 2016

Study to Evaluate Effects of a Weight Loss Program in Different Formats on Healthy Adults

Conditions:   Overweight and Obesity;   Weight Loss
Interventions:   Behavioral: Nutrisystem Turbo 10;   Behavioral: Nutrisystem My Way;   Behavioral: Nutrisystem DASH;   Behavioral: Dieting on Your Own (DIY) - DASH
Sponsors:   Nutrisystem, Inc.;   Biofortis Clinical Research, Inc.
Completed - verified January 2017

Comparison of Vitamin D Status in Patients With High Myopia and Primary Open-angle Glaucoma

Conditions:   Vitamin D Deficiency;   Primary Open-angle Glaucoma;   High Myopia
Intervention:   Other: Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by an enzyme-linked immuno-absorbent assay
Sponsor:   Lv Yingjuan
Completed - verified January 2017

A Phase 2/3 Trial of the the Efficacy and Safety of Bardoxolone Methyl in Patients With Alport Syndrome - CARDINAL

Condition:   Alport Syndrome
Interventions:   Drug: Placebo Oral Capsule;   Drug: Bardoxolone Methyl
Sponsor:   Reata Pharmaceuticals, Inc.
Not yet recruiting - verified January 2017

Body Composition, Dietary Behaviors, Energy Expenditure and Physical Activity Among Moroccan Schoolchildren and Adolescents

Conditions:   Body Composition;   Physical Activity
Intervention:  
Sponsors:   Centre National De L'énergie, Des Sciences Et Techniques Nucléaires;   Ministry of Education, Morocco;   Ibn Tofail University, Morocco;   International Atomic Energy Agency
Completed - verified January 2017

Melatonin in Pregnancy Compared to Non-pregnant

Condition:   Pregnancy Transient Hypertension
Intervention:  
Sponsors:   University of Aberdeen;   NHS Grampian
Recruiting - verified January 2017

Pulmonary Vascular Disease Phenomics Program PVDOMICS

Condition:   Pulmonary Arterial Hypertension
Intervention:   Other: No Intervention
Sponsors:   The Cleveland Clinic;   Brigham and Women's Hospital;   Columbia University;   Weill Medical College of Cornell University;   Johns Hopkins University;   Mayo Clinic;   University of Arizona;   Vanderbilt University
Recruiting - verified December 2016

Evaluation of Celecoxib Effects on Amlodipine in Subjects With Existing Hypertension Requiring Antihypertensives

Condition:   Hypertension
Interventions:   Drug: Over-encapsulated 10 mg amlodipine besylate tablet + over-encapsulated 200 mg celecoxib capsule;   Drug: Over-encapsulated 10 mg amlodipine besylate tablet + matched placebo capsule for over-encapsulated celecoxib capsule;   Drug: Matched placebo tablet for over-encapsulated amlodipine besylate tablet + matched placebo capsule for over-encapsulated celecoxib capsule
Sponsor:   Kitov Pharmaceuticals, Ltd.
Recruiting - verified January 2017

Preeclampsia Research on Vitamin D, Inflammation, & Depression

Conditions:   Pre-Eclampsia;   Depression;   Inflammation;   Vitamin D Deficiency
Intervention:   Other: mental health screening, education and referral program
Sponsors:   Cedars-Sinai Medical Center;   Maternal Mental Health NOW
Not yet recruiting - verified January 2017

Determination of the Sensitivity and Specificity of a Smartphone Application to Detect Retinoblastoma

Conditions:   Retinoblastoma;   Cataracts Infantile;   Glaucoma, Congenital;   Leucocoria
Interventions:   Other: CRADLE;   Device: Red reflex testing
Sponsor:   St. Jude Children's Research Hospital
Not yet recruiting - verified January 2017

Amlodipine Versus Valsartan for Improvement of Diastolic Dysfunction Associated With Hypertension

Condition:   Hypertension
Interventions:   Drug: Amlodipine;   Drug: Valsartan
Sponsors:   Asan Medical Center;   Yuhan Corporation
Recruiting - verified January 2017

Salt-sensitive Hypertension Study in Lantian County

Condition:   Hypertension
Intervention:   Dietary Supplement: salt
Sponsor:   First Affiliated Hospital Xi'an Jiaotong University
Not yet recruiting - verified September 2016

Randomized Study of the Safety and Effectiveness of the Sight Sciences VISCO™360 Viscosurgical System Versus SLT in Primary Open Angle Glaucoma (VISCO360 Study)

Condition:   Open-Angle Glaucoma
Interventions:   Device: VISCO360 ab interno canaloplasty surgery;   Device: Selective Laser Trabeculoplasty (SLT)
Sponsor:   Sight Sciences, Inc.
Recruiting - verified January 2017

Randomized Study to Assess the Safety, Pharmacokinetics/Dynamics of DS-1040b in Subjects With Acute Submassive Pulmonary Embolism

Conditions:   Pulmonary Embolism;   Thrombotic Disease
Interventions:   Drug: DS-1040b;   Drug: placebo
Sponsors:   Daiichi Sankyo Inc.;   International Trial Expertise and Advisory Servies (ITREAS);   Medpace, Inc.
Recruiting - verified January 2017

BAROSTIM THERAPY™ In Resistant Hypertension

Condition:   Hypertension
Intervention:   Device: Barostim Neo™ System
Sponsor:   CVRx, Inc.
Recruiting - verified January 2017

Continuous Monitoring Nocturnal Beat-to-beat Blood Pressure Fluctuation in OSA With or Without Hypertension

Condition:   Blood Pressure Disorders
Intervention:   Other: CPAP
Sponsor:   Huai'an No.1 People's Hospital
Recruiting - verified January 2017

BAROSTIM THERAPY™ In Heart Failure With Preserved Ejection Fraction

Condition:   Heart Failure
Intervention:   Device: BAROSTIM NEO™ System
Sponsor:   CVRx, Inc.
Enrolling by invitation - verified January 2017

Emricasan, an Oral Caspase Inhibitor, in Subjects With Non-Alcoholic Steatohepatitis (NASH) Cirrhosis and Severe Portal Hypertension

Conditions:   Cirrhosis;   Portal Hypertension;   Non-alcoholic Steatohepatitis
Interventions:   Drug: Emricasan;   Drug: Placebo
Sponsor:   Conatus Pharmaceuticals Inc.
Recruiting - verified January 2017

Mycophenolate Mofetil Versus Azathioprine in Treatment Naive Autoimmune Hepatitis

Condition:   Autoimmune Hepatitis
Interventions:   Drug: Mycophenolate mofetil;   Drug: Azathioprine
Sponsors:   Radboud University;   Leiden University Medical Center
Recruiting - verified August 2016

iPhone App Compared to Standard Riva-Rocci (RR)-Measurement During Stress Testing

Condition:   Blood Pressure
Interventions:   Device: cuff device;   Device: iphone
Sponsor:   University Hospital, Basel, Switzerland
Recruiting - verified January 2017

P.A.R.Q.V.E III - Comparison of the Educational Program With and Without Multidisciplinary Care

Conditions:   Osteoarthritis;   Metabolic Diseases
Interventions:   Behavioral: Womac;   Behavioral: Lequesne;   Behavioral: VAS;   Behavioral: IPAQ;   Behavioral: FTSST;   Behavioral: TUG;   Behavioral: Six-minute Test;   Behavioral: Two days of lectures;   Behavioral: Session with the psychologists;   Behavioral: Sessions with the physical therapy team;   Behavioral: Sessions with the physical educators team;   Behavioral: Nutritional habits to be improved;   Behavioral: Tampa Scale for Kinesiophobia (TSK)
Sponsor:   University of Sao Paulo General Hospital
Active, not recruiting - verified January 2017

Non-interventional, Postauthorization Safety Study of Ventavis for Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Ventavis (Iloprost, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified January 2017

Associations of Vitamin D Receptor ApaI and Tru9I Polymorphisms With the Risk of Primary Open-angle Glaucoma

Condition:   Primary Open- Angle Glaucoma
Intervention:   Other: Vitamin D receptor polymorphic analysis
Sponsors:   Lv Yingjuan;   Tianjin Medical University Eye Hospital
Completed - verified January 2017

Oxygen Therapy and Pregnancy in Sickle Cell Disease

Condition:   Sickle Cell Disease
Intervention:   Device: oxygen therapy
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting - verified January 2017

Long-term Oxygen Therapy in Patients With Chronic Obstructive Pulmonary Disease Who Live at High Altitude

Condition:   COPD
Intervention:   Drug: Oxygen
Sponsors:   Fundación Neumologica Colombiana;   Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnología (COLCIENCIAS)
Recruiting - verified January 2017

Sympathetic Mapping/ Ablation of Renal Nerves Trial

Condition:   Hypertension
Intervention:   Device: SyMapCath I™ catheter and SYMPIONEER S1™ Stimulator/Generator
Sponsors:   SyMap Medical (Suzhou), Ltd.;   Tigermed Consulting Co., Ltd
Recruiting - verified January 2017

A Long-term Extension Study of Riociguat in Patients With Symptomatic Pulmonary Arterial Hypertension.

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Adempas (Riociguat, BAY63-2521)
Sponsor:   Bayer
Recruiting - verified January 2017

The Diurnal and Nocturnal Effect of Pilocarpine on Intraocular Pressure and Ocular Perfusion Pressure

Conditions:   Glaucoma, Open-angle;   Hypertension, Ocular
Intervention:   Drug: Pilocarpine
Sponsor:   University of Colorado, Denver
Recruiting - verified January 2017

Late Permissive Hypercapnia for Intubated and Ventilated Preterm Infants

Condition:   Premature Neonate
Interventions:   Other: Higher permissive hypercapnia;   Other: Lower Permissive Hypercapnia
Sponsor:   University of Alabama at Birmingham
Recruiting - verified January 2017

Zambia One Love Aim 3 Trial

Conditions:   HIV;   Sexually Transmitted Diseases;   Neglected Diseases;   Non-communicable Diseases
Interventions:   Behavioral: Strengthening Our Vows (SOV);   Behavioral: Good Health Package Plus (GHPP)
Sponsor:   Emory University
Active, not recruiting - verified January 2017

Health Impacts of a Climate Change Adaptation Strategy to Address Drinking-water Salinity in Coastal Bangladesh

Condition:   Hypertension
Intervention:   Other: Managed Aquifer Recharge water
Sponsors:   International Centre for Diarrhoeal Disease Research, Bangladesh;   University of Dhaka;   University College, London;   Emory University
Recruiting - verified October 2016

Medication Adherence Improvement Support App For Engagement - Blood Pressure

Condition:   Hypertension
Intervention:   Other: Medisafe
Sponsors:   Brigham and Women's Hospital;   Medisafe, Inc.;   Evidation Health
Completed - verified January 2017

Prebiotic in Preventing Low Birth Weight

Conditions:   Birth Weight <2500gm;   Genitourinary Tract Infection
Interventions:   Dietary Supplement: Fructooligosaccharide;   Dietary Supplement: Pocari-Sweat
Sponsors:   International Centre for Diarrhoeal Disease Research, Bangladesh;   Karolinska Institutet;   Swedish International Development Cooperation Agency (SIDA)
Recruiting - verified December 2016

Evaluation of a New Thermostable Formulation of FLOLAN in Japanese Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: FLOLAN injection with currently marketed diluent;   Drug: FLOLAN injection with reformulated diluent
Sponsor:   GlaxoSmithKline
Completed - verified January 2017

A Phase 1 Relative Bioavailability Study of Ambrisentan and Tadalfil Fixed Dose Combination Tablets in Healthy Subjects

Condition:   Hypertension, Pulmonary
Interventions:   Drug: FDC (ambrisentan 10 mg-tadalafil 40 mg) single dose;   Drug: Reference (ambrisentan 10 mg + tadalafil 40 mg given concurrently)
Sponsors:   GlaxoSmithKline;   Covance Harrogate;   Hammersmith Medicines Research
Recruiting - verified January 2017

Adding MgSO4 to Epidural Levobupivacaine in CS for Patients With Preeclampsia

Condition:   Preeclampsia
Interventions:   Drug: Levobupivacaine hydrochloride;   Drug: Magnesium sulphate;   Drug: Saline 0.9%
Sponsor:   Mohamed Sayed Abdelhafez
Recruiting - verified January 2017

Veteran Peer Coaches Optimizing and Advancing Cardiac Health

Conditions:   Cardiovascular Disease (CVD);   Hypertension;   Hyperlipemia;   Obesity
Intervention:   Other: Community-based peer health coach intervention
Sponsor:   VA Office of Research and Development
Not yet recruiting - verified January 2017

Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic

Conditions:   Multiple System Atrophy;   Orthostatic Hypotension;   Supine Hypertension
Interventions:   Drug: Trimethaphan;   Drug: Placebo
Sponsor:   Vanderbilt University
Recruiting - verified January 2017

Pre-eclampsia and Biochemical Markers

Condition:   Detection of Preeclampsia Complications
Intervention:  
Sponsor:   Assiut University
Recruiting - verified January 2017

Advanced MRI for Uteroplacental Flow, Perfusion, Oxygenation & Inflammation

Conditions:   Pregnancy;   Obesity;   Preeclampsia
Interventions:   Procedure: Ultrasound Scan;   Procedure: MRI Scan
Sponsors:   University of Wisconsin, Madison;   National Institutes of Health (NIH)
Not yet recruiting - verified January 2017

Measuring the Impact of Dietary Supplementation With a New Baking Product on Gut Microbiota and Cholesterol Metabolism

Condition:   Hypercholesterolemia
Interventions:   Dietary Supplement: PreBIOil;   Dietary Supplement: Control
Sponsors:   Fondazione Edmund Mach;   Casa di Cura Eremo di Arco (TN) Italy;   OlioCRU Consorzio srl Arco (TN) Italy
Completed - verified January 2017

Using Practice Facilitation in Primary Care Settings to Reduce Risk Factors for Cardiovascular Disease

Conditions:   Cardiovascular Disease;   High Blood Pressure
Interventions:   Behavioral: Million Hearts ABCS 6 Months;   Behavioral: Million Hearts ABCS 9 Months;   Behavioral: Million Hearts ABCS 12 Months;   Behavioral: Million Hearts ABCS 15 Months;   Behavioral: Standard Care Regimen 9 Months;   Behavioral: Standard Care Regimen 12 Months;   Behavioral: Standard Care Regimen 15 Months;   Behavioral: Standard Care Regimen 18 Months;   Behavioral: Standard Care Regimen 21 Months;   Behavioral: Standard Care Regimen 24 Months;   Behavioral: Standard Care Regimen 27 Months;   Behavioral: Follow Up Post Intervention 21 Months;   Behavioral: Follow Up Post Intervention 24 Months;   Behavioral: Follow Up Post Intervention 27 Months;   Behavioral: Follow Up Post Intervention 30 Months;   Behavioral: Follow Up Post Intervention 33 Months
Sponsors:   New York University School of Medicine;   Agency for Healthcare Research and Quality (AHRQ)
Active, not recruiting - verified January 2017

Dexmedetomidine vs. Midazolam Sedation for Endobronchial Ultrasound

Conditions:   Conscious Sedation During Procedure;   Endobronchial Ultrasound
Interventions:   Drug: Dexmedetomidine;   Drug: Midazolam bolus;   Other: Saline placebo;   Drug: Rescue midazolam;   Drug: Fentanyl
Sponsor:   Postgraduate Institute of Medical Education and Research
Active, not recruiting - verified January 2017

Renal Sympathetic Denervation From The Adventitia on Hypertension

Condition:   Primary Aldosteronism Due to Aldosterone Producing Adenoma
Intervention:   Device: Renal Sympathetic Denervation
Sponsor:   Henan Institute of Cardiovascular Epidemiology
Recruiting - verified January 2017

Metabolic Effects of Angiotensin-(1-7)

Conditions:   Obesity;   Insulin Resistance;   Hypertension;   Metabolic Cardiovascular Syndrome
Interventions:   Drug: Angiotensin-(1-7);   Drug: Saline
Sponsor:   Vanderbilt University
Recruiting - verified January 2017

An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease;   Combined Pulmonary Fibrosis and Emphysema
Intervention:   Drug: Inhaled Treprostinil
Sponsor:   United Therapeutics
Enrolling by invitation - verified January 2017

Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease;   Combined Pulmonary Fibrosis and Emphysema
Interventions:   Drug: Inhaled Treprostinil;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting - verified January 2017

A RCT of CenteringPregnancy on Birth Outcomes

Conditions:   Pregnancy;   Preterm Birth
Intervention:   Behavioral: CenteringPregnancy
Sponsors:   Clemson University;   Greenville Health System
Recruiting - verified January 2017

The Expression of Matrix Metalloproteinase 13, Tissue Inhibitor of Metalloproteinases 3, and Calcium-sensing Receptor in Human Trabecular Meshwork

Condition:   Open-angle Glaucoma
Intervention:   Procedure: trabeculectomy
Sponsor:   Lv Yingjuan
Completed - verified January 2017

How Safe and Effective is Micropulse Transscleral Cyclophotocoagulation in Patients With Uncontrolled Glaucoma?

Condition:   Glaucoma
Intervention:   Procedure: Micropulse Transscleral Cyclophotocoagulation
Sponsor:   Wills Eye
Active, not recruiting - verified January 2017

Treatment of Hypertension In Adults With ThiaZIDES: Pragmatic Trial Pilot Study

Condition:   Hypertension
Intervention:   Behavioral: HCTZ prescription conversion to chlorthalidone
Sponsors:   HealthPartners Institute;   Kaiser Permanente
Enrolling by invitation - verified January 2017

Optic Nerve Head Quantification While Reducing Elevated Intracranial Pressure

Conditions:   Intraocular Pressure;   Intracranial Hypertension
Intervention:  
Sponsor:   New York University School of Medicine
Withdrawn - verified January 2017

Double-masked Study of PG324 Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension

Conditions:   Open-angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: PG324 Ophthalmic Solution;   Drug: Netarsudil (AR-13324) Ophthalmic Solution;   Drug: Latanoprost Ophthalmic Solution
Sponsor:   Aerie Pharmaceuticals
Active, not recruiting - verified January 2017

Double-masked Study of Netarsudil (AR-13324) Ophthalmic Solution in Subjects With Glaucoma or Ocular Hypertension

Conditions:   Open-angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Netarsudil (AR-13324) Ophthalmic Solution;   Drug: Timolol Maleate Ophthalmic Solution
Sponsor:   Aerie Pharmaceuticals
Active, not recruiting - verified January 2017

Egypt Hypertension Study

Condition:   Different Classes of the Antihypertensive Treatment
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified January 2017

Electronic Activity Level Monitoring Pilot in Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Hypertension, Pulmonary
Intervention:   Other: Correlation assessment
Sponsor:   Bayer
Completed - verified January 2017

Efficacy and Safety of Candesartan Associated With Chlorthalidone in Essential Arterial Hypertension Control

Condition:   Essential Arterial Hypertension
Interventions:   Drug: Candesartan + Chlorthalidone (8mg+12,5mg);   Drug: Candesartan + Chlorthalidone (8 mg + 25 mg);   Drug: losartan+hydrochlorothiazide
Sponsor:   EMS
Withdrawn - verified January 2017

Efficacy and Safety of Candesartan Associated With Chlorthalidone Versus Losartan Associated With Hydrochlorothiazide (Hyzaar®) in Essential Hypertension Control

Condition:   Essential Arterial Hypertension
Interventions:   Drug: Candesartan + Chlorthalidone;   Drug: Candesartan + Chlorthalidone;   Drug: Losartan+hydrochlorothiazide
Sponsor:   EMS
Withdrawn - verified January 2017

Multi-micronutrient Supplementation During Peri-conception and Congenital Heart Disease

Condition:   Congenital Heart Disease
Interventions:   Dietary Supplement: Vitamin B Complex and Folic Acid;   Dietary Supplement: Iron and Folic Acid;   Dietary Supplement: Folic Acid
Sponsor:   Health Science Center of Xi’an Jiaotong University
Recruiting - verified January 2017

Exercise and Pharmacotherapy for Anxiety in Cardiac Patients

Conditions:   Anxiety;   Cardiovascular Disease
Interventions:   Drug: Lexapro;   Drug: Placebo;   Behavioral: Supervised Aerboic Exercise
Sponsor:   Duke University
Recruiting - verified January 2017

Efficacy and Safety of Olmesartan Associated With Chlorthalidone in Essential Arterial Hypertension Control

Condition:   Essential Arterial Hypertension
Interventions:   Drug: Olmesartan Medoxomil 20mg + Chlorthalidone 12,5mg;   Drug: Olmesartan medoxomil 20mg + Chlortalidone 25mg;   Drug: Olmesartan 20mg + hydrochlorothiazide 12,5mg
Sponsor:   EMS
Not yet recruiting - verified January 2017

Efficacy and Safety of Olmesartan Associated With Chlorthalidone Versus Benicar HCT® in Essential Hypertension Control

Condition:   Arterial Hypertension
Interventions:   Drug: Olmesartan medoxomil 40mg + chlorthalidone 12,5mg;   Drug: Olmesartan medoxomil 40mg + chlorthalidone 25mg;   Drug: Olmesartan 40mg + Hydrochlorothiazide 12,5mg;   Drug: Olmesartan 40mg + Hydrochlorothiazide 25mg
Sponsor:   EMS
Not yet recruiting - verified January 2017

Southwest Health Extension Partnership to Enhance Research Dissemination

Condition:   Cardiovascular Diseases
Interventions:   Other: Enhanced practice transformation support;   Other: Standard practice transformation support
Sponsors:   University of Colorado, Denver;   University of New Mexico
Recruiting - verified January 2017

Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Hyperoxaluria and Kidney Stones

Conditions:   Secondary Hyperoxaluria;   Nephrolithiasis;   Kidney Stones;   Hyperoxaluria;   Dietary Hyperoxaluria
Interventions:   Drug: ALLN-177 low dose;   Drug: ALLN-177 mid dose;   Drug: ALLN-177 high dose;   Drug: Placebo
Sponsor:   Allena Pharmaceuticals
Completed - verified January 2017

To Compare the Efficacy and Safety of Carvedilol With or Without Simvastatin in Patients With Portal Hypertension and Esophageal Varices.

Condition:   Cirrhosis With Esophageal Varices
Interventions:   Drug: Carvedilol;   Drug: Carvedilol + Simvastatin
Sponsor:   Institute of Liver and Biliary Sciences, India
Recruiting - verified January 2017

The Clinical Utility of the Congo-Red Dot Test for Diagnosis and Early Prediction of Preeclampsia During Pregnancy

Condition:   Preeclampsia
Intervention:  
Sponsor:   Buhimschi, Catalin S, MD
Recruiting - verified January 2017

Natural History of Noncirrhotic Portal Hypertension

Conditions:   Cystic Fibrosis;   Immunologic Deficiency Syndrome;   Turner Syndrome;   Congenital Hepatic Fibrosis;   Idiopathic Non-Cirrhotic Portal Hypertension
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 2017

Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension

Condition:   Hypertension
Interventions:   Drug: Trimethaphan;   Drug: Nitroglycerin
Sponsor:   Vanderbilt University
Recruiting - verified January 2017

A Study of Vonapanitase (PRT-201) Administered Immediately After Radiocephalic Arteriovenous Fistula(AVF) Creation in Patients With Chronic Kidney Disease (CKD) (PATENCY-2)

Condition:   Chronic Kidney Disease
Interventions:   Drug: vonapanitase;   Drug: Placebo
Sponsor:   Proteon Therapeutics
Recruiting - verified January 2017

Multiple Sclerosis: Associated Cardiometabolic Risks and Impact of Exercise Therapy

Conditions:   Multiple Sclerosis;   Healthy Controls
Intervention:   Behavioral: Physical exercise
Sponsor:   Bert Op't Eijnde
Completed - verified January 2017

Effects of High Altitude on AMPK Activation

Conditions:   Pregnancy;   IUGR;   Preeclampsia
Intervention:   Procedure: Collection of myometrial, cord blood, and placental tissue samples
Sponsor:   University of Colorado, Denver
Recruiting - verified January 2017

Trial of Vitamin D Supplements to Raise Calcidiol Levels of Pregnant Women in Mongolia

Conditions:   Pregnancy;   Vitamin D Deficiency
Interventions:   Dietary Supplement: 600 IU Vitamin D3 in prenatal vitamin;   Dietary Supplement: 2000 IU Vitamin D3 in prenatal vitamin;   Dietary Supplement: 4000 IU Vitamin D3 in prenatal vitamin
Sponsors:   Brigham and Women's Hospital;   National Center for Maternal and Child Health Research, Mongolia;   Zuun Kharaa Hospital
Completed - verified January 2017

Transparent Cap-assisted Endoscopic Sclerotherapy

Condition:   Esophageal Varices
Interventions:   Procedure: assistance of a transparent cap;   Procedure: without a transparent cap
Sponsor:   Shanghai Zhongshan Hospital
Completed - verified January 2017

REPAIR: Right vEntricular Remodeling in Pulmonary ArterIal hypeRtension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Recruiting - verified January 2017

The CREATE Wellness Study

Conditions:   Diabetes;   Heart Disease;   Hypertension;   Dyslipidemia
Interventions:   Behavioral: CREATE Wellness;   Other: Usual Care Control
Sponsors:   Kaiser Permanente;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified January 2017

Phase III Trial BI 695502 Plus Chemotherapy vs. Avastin® Plus Chemotherapy in Patients With Lung Cancer

Condition:   Carcinoma, Non-Small-Cell Lung
Interventions:   Drug: Chemotherapy;   Drug: BI 695502;   Drug: bevacizumab;   Drug: Chemotherapy
Sponsor:   Boehringer Ingelheim
Recruiting - verified January 2017

Cardiovascular Effects of Angiotensin (1-7) in Essential Hypertension

Conditions:   Hypertension;   Hypertension, Essential
Interventions:   Drug: Angiotensin (1-7);   Drug: Trimethaphan;   Drug: Phenylephrine
Sponsor:   Vanderbilt University
Recruiting - verified January 2017

Study of Netarsudil (AR-13324) Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension

Conditions:   Ocular Hypertension;   Glaucoma
Interventions:   Drug: Netarsudil (AR-13324) Ophthalmic Solution q.d.;   Drug: Netarsudil (AR-13324) Ophthalmic Solution b.i.d.;   Drug: Timolol maleate Ophthalmic Solution b.i.d.
Sponsor:   Aerie Pharmaceuticals
Active, not recruiting - verified January 2017

Laparoscopy-assisted and Open Distal Gastrectomy for Gastric Cancer in the Elderly Patients

Condition:   Complications
Interventions:   Procedure: Laparoscopic gastrectomy;   Procedure: Open gastrectomy
Sponsor:   Nanfang Hospital of Southern Medical University
Recruiting - verified January 2017

Pulmonary Arterial Denervation in Patients With Pulmonary Arterial Hypertension Associated With the Left Heart Failure

Condition:   Pulmonary Hypertension
Interventions:   Procedure: Pulmonary arterial denervation;   Drug: Standard treatment
Sponsor:   The First Affiliated Hospital with Nanjing Medical University
Recruiting - verified January 2017

ESTEEM - Effect of Simple, Targeted Diet in Pregnant Women With Metabolic Risk Factors on Pregnancy Outcomes

Conditions:   Pre-eclampsia;   Obesity;   Raised Lipids;   High Blood Pressure;   Insulin Resistance;   Gestational Diabetes;   Small for Gestational Age;   Stillbirth
Interventions:   Behavioral: Targeted ESTEEM diet;   Other: Non-randomised cohort
Sponsor:   Queen Mary University of London
Active, not recruiting - verified January 2017

Post Market Study of the InnFocus MicroShunt

Condition:   Primary Open Angle Glaucoma
Intervention:   Device: InnFocus MicroShunt implantation
Sponsor:   InnFocus Inc.
Active, not recruiting - verified January 2017

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease (CKD), Not on Dialysis

Condition:   Anemia
Interventions:   Drug: Roxadustat;   Drug: Placebo
Sponsors:   AstraZeneca;   FibroGen
Recruiting - verified January 2017

Efficacy, Safety, and Tolerability of Selonsertib (GS-4997) in Participants With Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Selonsertib;   Drug: Placebo to match selonsertib
Sponsor:   Gilead Sciences
Completed - verified January 2017

Clinical Trial in Patients With Hypertension and Left Ventricular Dysfunction

Conditions:   Hypertension;   Cardiac Arrhythmias;   Diabetes Mellitus;   Renal Insufficiency;   Sleep Apnea
Intervention:  
Sponsor:   Elpen Pharmaceutical Co. Inc.
Recruiting - verified January 2017

Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH )

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Recruiting - verified January 2017

Blood Pressure, Cerebral Blood Flow and Cognition in Spinal Cord Injury

Condition:   Spinal Cord Injury
Interventions:   Drug: Midodrine;   Drug: Placebo
Sponsors:   James J. Peters Veterans Affairs Medical Center;   Kessler Foundation
Recruiting - verified January 2017

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy;   Device: Carotid stenting
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2017

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Conditions:   Hypertension;   Cardiovascular Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting - verified January 2017

A Phase 2 Single-Masked, Randomized Study of Latanoprost PPDS in Ocular Hypertension or Open-Angle Glaucoma

Conditions:   Ocular Hypertension;   Open-Angle Glaucoma
Intervention:   Drug: Latanoprost Punctal Plug Delivery System (L-PPDS)
Sponsor:   Mati Therapeutics Inc.
Completed - verified January 2017

BNP Pharmacodynamics and Effects on Metabolism in Lean and Obese Subjects

Conditions:   Obesity;   Cardiovascular Disease;   Hypertension;   Diabetes
Interventions:   Drug: Nesiritide;   Drug: Saline
Sponsors:   Translational Research Institute for Metabolism and Diabetes, Florida;   Sanford-Burnham Medical Research Institute
Active, not recruiting - verified January 2017

Non-interventional Study on Compliance of Inhaled Treatment With Ventavis in Patient With Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Iloprost (Ventavis, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified January 2017

The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Terminated - verified January 2017

Community Level Interventions for Pre-eclampsia

Conditions:   Pre-eclampsia;   Hypertension, Pregnancy Induced
Interventions:   Behavioral: Community Engagement;   Device: PIERS on the Move mHealth decision aid;   Drug: Magnesium Sulfate;   Drug: Methyldopa
Sponsors:   University of British Columbia;   Bill and Melinda Gates Foundation;   Olabisi Onabanjo University;   Centro de Investigacao em Saude de Manhica;   Aga Khan University;   Jawaharlal Nehru Medical College
Recruiting - verified January 2017

InnFocus MicroShunt Versus Trabeculectomy Study

Condition:   Primary Open Angle Glaucoma
Interventions:   Procedure: Glaucoma Surgery;   Device: InnFocus MicroShunt
Sponsor:   InnFocus Inc.
Recruiting - verified January 2017

Greek Physicians Perceptions Regarding Generics Prescribing in Glaucoma

Condition:   Glaucoma
Intervention:  
Sponsor:   Democritus University of Thrace
Completed - verified January 2017

Proton w/FOLFIRINOX-Losartan for Pancreatic Cancer

Condition:   Pancreatic Cancer
Interventions:   Drug: FOLFIRINOX;   Drug: Losartan;   Radiation: Proton Beam Radiation
Sponsors:   Massachusetts General Hospital;   National Cancer Institute (NCI)
Recruiting - verified January 2017

Measurement of Autonomic Cardiovascular Integrity in Persons With SCI

Condition:   Spinal Cord Injury
Intervention:  
Sponsor:   James J. Peters Veterans Affairs Medical Center
Recruiting - verified January 2017

Resveratrol and the Metabolic Syndrome

Conditions:   Obesity;   Insulin Resistance;   Metabolic Syndrome
Interventions:   Dietary Supplement: Placebo;   Dietary Supplement: Resveratrol
Sponsor:   Rockefeller University
Active, not recruiting - verified January 2017

Use of Intravitreal Aflibercept Injection for Neovascular Glaucoma

Condition:   Neovascular Glaucoma
Intervention:   Drug: Aflibercept
Sponsor:   University of Colorado, Denver
Completed - verified January 2017

A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn

Condition:   Pulmonary Hypertension, Familial Persistent, of the Newborn
Interventions:   Drug: placebo;   Drug: iv sildenafil
Sponsor:   Pfizer
Recruiting - verified January 2017

Safety and Performance of Miami InnFocus Drainage Implant (MIDI Arrow) Glaucoma Drainage Implant

Condition:   Primary Open Angle Glaucoma
Intervention:   Device: MIDI Arrow
Sponsor:   InnFocus Inc.
Completed - verified January 2017

ENLIGHTEN: Exercise and NutritionaL Interventions for coGnitive and Cardiovascular HealTh ENhancement

Condition:   Cognitive Impairment, no Dementia (CIND)
Interventions:   Behavioral: Aerobic Exercise;   Behavioral: DASH diet;   Other: Health education control
Sponsor:   Duke University
Active, not recruiting - verified January 2017

A Pharmacokinetics Study for Pediatric Participants With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Tadalafil- Tablet
Sponsor:   Eli Lilly and Company
Recruiting - verified January 2017

Long-term Ambrisentan Extension Study for Pediatric Patients Who Participated in AMB112529

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Ambrisentan
Sponsor:   GlaxoSmithKline
Recruiting - verified January 2017

A Survey to Evaluate Diabetes Management, Control, Chronic Complications, Psychosocial Aspects of Diabetic Subjects in India

Conditions:   Diabetes;   Diabetes Mellitus, Type 1;   Diabetes Mellitus, Type 2
Intervention:   Other: No treatment given
Sponsor:   Novo Nordisk A/S
Completed - verified January 2017

Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure

Conditions:   Hypertension;   Pure Autonomic Failure;   Multiple System Atrophy
Interventions:   Drug: Losartan;   Drug: Captopril;   Drug: Placebo
Sponsor:   Vanderbilt University
Recruiting - verified January 2017

Therapeutic Targeting of Stress Factors in Ovarian Cancer Patients

Conditions:   Invasive Epithelial Ovarian Cancer;   Primary Peritoneal Carcinoma;   Fallopian Tube Cancer
Intervention:   Drug: Propranolol
Sponsor:   Washington University School of Medicine
Completed - verified January 2017

Noninvasive Cardiac Output Measurements in Patients With Pulmonary Hypertension Undergoing Right Heart Catheterization With Acute Vasodilator Testing

Condition:   Pulmonary Hypertension
Intervention:  
Sponsor:   University of Chicago
Withdrawn - verified January 2017

Establishment of Biomarkers for Fabry Disease

Condition:   Fabry Disease
Intervention:   Other: Fluorescein angiography
Sponsors:   Ohio State University;   Genzyme, a Sanofi Company
Completed - verified January 2017

Pathophysiology of Cardiometabolic Risk Factors in African Americans

Conditions:   Obesity;   Hypertension
Interventions:   Drug: L-NMMA;   Drug: Trimethaphan
Sponsors:   Vanderbilt University Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2017

The Role of Endothelin in the Supine Hypertension of Autonomic Failure

Conditions:   Hypertension;   Pure Autonomic Failure;   Multiple System Atrophy
Interventions:   Drug: BQ123;   Drug: BQ123;   Drug: Bq123;   Drug: BQ123;   Drug: Saline
Sponsor:   Vanderbilt University
Recruiting - verified January 2017

A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunction

Conditions:   Hypertension, Pulmonary;   Ventricular Dysfunction, Left
Interventions:   Drug: Riociguat (Adempas, BAY63-2521);   Drug: Riociguat (Adempas, BAY63-2521);   Drug: Riociguat (Adempas, BAY63-2521);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting - verified January 2017

Evaluation of Aliskiren Efficacy by Different Methods of Blood Pressure Measurements

Condition:   Blood Pressure, High
Intervention:   Drug: Aliskiren
Sponsors:   Meir Medical Center;   Novartis Pharmaceuticals
Terminated - verified May 2011

Live Kidney Donor Study - Cross-Sectional and Historical Cohort Study

Conditions:   End Stage Renal Disease;   Transplantation
Intervention:  
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   National Heart, Lung, and Blood Institute (NHLBI);   Health Resources and Services Administration (HRSA)
Completed - verified January 2017

Randomized Conversion of Calcineurin-Inhibitors in Renal Allograft Recipients

Condition:   Renal Transplant Rejection
Interventions:   Drug: Sirolimus;   Other: Demographic Data, Medical History, and Donor Data;   Procedure: Blood Draws for Control Group;   Procedure: Blood Draws for Experimental Group;   Procedure: Donor Blood Draws;   Other: Donor Information;   Procedure: Kidney Biopsy
Sponsors:   Northwestern University;   Wyeth is now a wholly owned subsidiary of Pfizer
Active, not recruiting - verified January 2017

PTGS1 Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn

Condition:   Persistent Pulmonary Hypertension of the Newborn
Intervention:  
Sponsor:   Medical College of Wisconsin
Recruiting - verified January 2017

Primary Tube Versus Trabeculectomy Study

Condition:   Glaucoma
Interventions:   Procedure: Tube shunt surgery;   Procedure: Trabeculectomy with mitomycin C
Sponsors:   Bascom Palmer Eye Institute;   Abbott Medical Optics;   Research to Prevent Blindness;   National Eye Institute (NEI)
Active, not recruiting - verified January 2017

Evaluation of Patients With Liver Disease

Conditions:   Biliary Liver Cirrhosis;   Hemochromatosis;   Hepatitis;   Hepatolenticular Degeneration;   Liver Disease
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 2017

Novel Diagnostics With Optical Coherence Tomography: Retinal Imaging

Conditions:   Macular Degeneration;   Glaucoma;   Diabetic Retinopathy
Intervention:  
Sponsors:   New York University School of Medicine;   National Eye Institute (NEI)
Active, not recruiting - verified January 2017

Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial

Conditions:   Preeclampsia;   Pregnancy Induced Hypertension;   Gestational Hypertension;   Chronic Hypertension;   Superimposed Preeclampsia
Interventions:   Drug: labetalol (seizure prevention);   Drug: MgSO4 (seizure prevention)
Sponsor:   Baylor College of Medicine
Withdrawn - verified January 2017

Novel Diagnostics for Ocular Structure

Conditions:   Glaucoma;   Macular Disease
Intervention:  
Sponsors:   New York University School of Medicine;   National Eye Institute (NEI)
Active, not recruiting - verified January 2017

Treatment of Supine Hypertension in Autonomic Failure

Condition:   Hypertension
Interventions:   Drug: Clonidine;   Drug: Nitroglycerin transdermal;   Drug: Dipyridamole/ Aspirin (Aggrenox);   Drug: Desmopressin (DDAVP);   Drug: Sildenafil;   Drug: Nifedipine;   Drug: Hydralazine;   Drug: Hydrochlorothiazide;   Drug: Placebo;   Drug: Bosentan;   Drug: Diltiazem;   Drug: Eplerenone;   Drug: guanfacine;   Dietary Supplement: L-arginine;   Drug: captopril;   Drug: carbidopa;   Drug: losartan;   Drug: metoprolol tartrate;   Drug: nebivolol hydrochloride;   Drug: prazosin hydrochloride;   Drug: tamsulosin hydrochloride;   Other: Head-up tilt.;   Drug: aliskiren;   Other: Local heat stress
Sponsor:   Vanderbilt University
Completed - verified January 2017

The Autonomic Nervous System and Obesity

Conditions:   OBESITY;   HYPERTENSION;   PURE AUTONOMIC FAILURE;   SHY-DRAGER SYNDROME
Interventions:   Drug: Trimethaphan;   Drug: Trimethaphan;   Drug: Pseudoephedrine
Sponsor:   Vanderbilt University
Completed - verified January 2017

Using Smokeless Tobacco Products With Lower Nicotine Levels to Reduce Negative Effects of Smokeless Tobacco Use

Condition:   Tobacco Use Disorder
Interventions:   Other: Lower Nicotine Smokeless Tobacco Product;   Other: Behavioral Counseling
Sponsor:   National Institute on Drug Abuse (NIDA)
Completed - verified June 2008

Effectiveness of Using Tobacco Free Snuff in Reducing Negative Effects of Smokeless Tobacco Use

Condition:   Tobacco Use Disorder
Intervention:   Drug: Tobacco free snuff
Sponsor:   National Institute on Drug Abuse (NIDA)
Completed - verified June 2008

Treatment of Orthostatic Hypotension in Autonomic Failure

Conditions:   Autonomic Failure;   Orthostatic Hypotension
Interventions:   Drug: Atomoxetine;   Drug: Acarbose;   Drug: Pyridostigmine Bromide;   Drug: Yohimbine;   Drug: Midodrine HCl;   Drug: placebo;   Drug: Modafinil;   Drug: Octreotide;   Other: water intake;   Drug: Diphenhydramine Hydrochloride;   Drug: Ranitidine HCL;   Drug: Tranylcypromine;   Drug: Ergotamine/ Caffeine;   Drug: Celecoxib;   Drug: Pseudoephedrine;   Drug: Methylphenidate;   Drug: Indomethacin;   Drug: Ibuprofen;   Drug: Oxymetazoline 0.05% nasal solution;   Dietary Supplement: Bovril;   Drug: Acetazolamide;   Drug: Rivastigmine tartrate;   Drug: Carbidopa/levodopa;   Device: Inflatable abdominal binder;   Device: inflatable abdominal binder (sham)
Sponsor:   Vanderbilt University
Completed - verified January 2017

Proteomics of Brain Trauma-associated Elevated Intracranial Pressure (ICP)

Conditions:   Brain Injuries, Traumatic;   Traumatic Brain Injury
Intervention:   Other: Blood/saliva samples for protein/molecular analysis
Sponsors:   The University of Texas Health Science Center, Houston;   TIRR/Mission Connect;   The Center for Clinical and Translational Sciences (CCTS) Clinical Research Unit at The University of Texas Health Science Center at Houston
Active, not recruiting - verified January 2017

COREG MR Versus TOPROL-XL On Reduction Of Microalbuminuria In Patients With Hypertension And Microalbuminuria

Condition:   Heart Failure, Congestive and Microalbuminuria
Interventions:   Drug: metoprolol xl;   Drug: carvedilol MR;   Drug: lisinopril
Sponsor:   GlaxoSmithKline
Terminated - verified January 2017

The Effects of Metformin on Blood Vessel Structure and Function

Conditions:   Obesity;   Hypertension;   Hypercholesterolemia;   Hyperglycemia
Interventions:   Drug: Metformin;   Drug: Placebo
Sponsor:   National Institute on Aging (NIA)
Completed - verified January 2017