High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Right Ventricular Function at Rest in Highlanders/Lowlanders

Condition:   High Altitude Pulmonary Hypertension
Intervention:  
Sponsors:   University of Zurich;   National Center of Cardiology and Internal Medicine, Kyrgyzstan
Recruiting - verified May 2017

Right Ventricular Function During Exercise in Highlanders/Lowlanders

Condition:   High Altitude Pulmonary Hypertension
Intervention:  
Sponsors:   University of Zurich;   National Center of Cardiology and Internal Medicine, Kyrgyzstan
Recruiting - verified May 2017

To Test the Effectiveness of a Trained Nurse Led, M-health Enabled Intervention to Control Blood Pressure in India

Condition:   Hypertension
Interventions:   Other: Intervention;   Other: Control
Sponsors:   Centre for Chronic Disease Control, India;   All India Institute of Medical Sciences, New Delhi;   Indian Council of Medical Research
Enrolling by invitation - verified May 2017

Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.

Conditions:   High Altitude Pulmonary Hypertension;   Sleep Apnea
Intervention:  
Sponsors:   University of Zurich;   National Center of Cardiology and Internal Medicine, Kyrgyzstan
Recruiting - verified May 2017

Evaluation of Sleep Pattern and Mood Profile in Hypertensive Patients

Condition:   Sleep
Intervention:   Other: No intervantion. It´s a Cross-Sectional Study
Sponsor:   Universidade Federal de Goias
Recruiting - verified May 2017

Young Adult Hypertension Self-Management Clinical Trial

Conditions:   Hypertension;   Blood Pressure;   Lifestyle Risk Reduction
Interventions:   Behavioral: Home Blood Pressure Monitoring;   Behavioral: Telephone Health Coaching
Sponsors:   University of Wisconsin, Madison;   National Heart, Lung, and Blood Institute (NHLBI);   Aurora Health Care
Not yet recruiting - verified May 2017

Prevalence of Hypertensive Disease in Patients Presenting for Elective Surgery in the Western Cape, South Africa

Condition:   Hypertensive Episode
Intervention:  
Sponsor:   University of Cape Town
Completed - verified May 2017

Combination of Fimasartan/Amlodipine/Rosuvastatin in Patients With Essential Hypertension and Dyslipidemia

Conditions:   Essential Hypertension;   Dyslipidemia
Interventions:   Drug: Fimasartan/Amlodipine, Rosuvastatin;   Drug: Fimasartan/Amlodipine;   Drug: Fimasartan, Rosuvastatin
Sponsor:   Boryung Pharmaceutical Co., Ltd
Not yet recruiting - verified May 2017

Angiogenic Imaging in Pulmonary Arterial Hypertension

Conditions:   Pulmonary Arterial Hypertension;   Exercise Associated Pulmonary Arterial Hypertension
Intervention:   Diagnostic Test: PET-CT Imaging with [89Zr]-bevacizumab
Sponsors:   Brigham and Women's Hospital;   Boston Biomedical Innovation Center
Not yet recruiting - verified May 2017

The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study

Conditions:   Mitral Regurgitation;   Pulmonary Hypertension
Interventions:   Diagnostic Test: Cardiac catheterisation;   Diagnostic Test: Cardiopulmonary exercise testing;   Diagnostic Test: Pulmonary function tests;   Diagnostic Test: Cardiac MRI;   Other: Quality of life survey;   Procedure: Mitral valve operation;   Procedure: Myocardial biopsies
Sponsor:   Imperial College London
Recruiting - verified May 2017

Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia

Condition:   Severe Preeclampsia
Intervention:   Drug: Magnesium Sulfate
Sponsor:   Assiut University
Recruiting - verified May 2017

The DNA Methylation of ARHGEF11 in Macrosomia

Conditions:   Gestational Diabetes;   Diabetes;   Macrosomia, Fetal
Intervention:   Diagnostic Test: OGTT
Sponsor:   Peking University First Hospital
Completed - verified May 2017

Hemodynamic Changes During Operative Hysteroscopy

Condition:   Hypertension
Interventions:   Drug: Normal Saline 0.9% Infusion Solution Bag;   Drug: 1.5% Glycine only
Sponsor:   Assiut University
Not yet recruiting - verified May 2017

Right Heart Catheterization Using Magnetic Resonance Imaging Fluoroscopy and Passive Guidewires

Conditions:   Pulmonary Artery Hypertension;   Congenital Heart Disease
Intervention:   Procedure: MRI Right Heart guidewire catheterization
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified May 15, 2017

Atherosclerosis-Progression in Coronary Arteries Compared to Periphery Vessels

Condition:   Atherosclerosis
Intervention:  
Sponsor:   Medical University Innsbruck
Recruiting - verified May 2017

Adipose Tissue Expadability and Type 2 Diabetes

Condition:   Type2 Diabetes Mellitus
Intervention:  
Sponsor:   Charles University, Czech Republic
Recruiting - verified July 2016

Acute and Chronic Responses to Blood Pressure After Exercise

Condition:   Arterial Hypertension
Intervention:   Other: physical exercises
Sponsor:   Federal University of Uberlandia
Completed - verified May 2017

Radiomics-based Hepatic Venous Pressure Gradient (rHVPG) (CHESS-02)

Condition:   Hypertension, Portal
Interventions:   Procedure: HVPG measurement;   Procedure: CTA
Sponsors:   Nanfang Hospital of Southern Medical University;   302 Hospital of PLA;   Beijing Shijitan Hospital;   Third Affiliated Hospital, Sun Yat-Sen University;   First Affiliated Hospital, Sun Yat-Sen University;   Beijing Ditan Hospital;   The Third Xiangya Hospital of Central South University;   PLA Army General Hospital;   Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University;   Xingtai People's Hospital
Recruiting - verified May 2017

Changes in Choroidal Thickness After Non Penetrating Deep Sclerectomy

Conditions:   Choroidal Thickness;   Open Angle Glaucoma;   Non Penetrating Deep Sclerectomy
Intervention:   Procedure: Non penetrating deep sclerectomy
Sponsors:   Germans Trias i Pujol Hospital;   Pau Romera Romero;   Jorge Loscos Arenas;   Nevena Romanic Bubalo;   Jordi Castellví Manent
Not yet recruiting - verified May 2017

Safety and Efficacy of Three Local Block Techniques for Diabetic Foot Surgery

Condition:   Anesthesia, Regional
Interventions:   Procedure: sciatic nerve block;   Procedure: ankle block;   Drug: Bupivacaine
Sponsor:   Assiut University
Not yet recruiting - verified May 2017

Glaucoma Management Optimism for African Americans Living With Glaucoma

Condition:   Glaucoma
Intervention:   Behavioral: Usual Care + Health Promotion Intervention
Sponsor:   University of Alabama at Birmingham
Not yet recruiting - verified May 2017

Digital Ankle Brachial Index (ABI) as a Screening Tool in Detecting Peripheral Arterial Disease

Conditions:   Peripheral Artery Disease;   Amputation;   Smoking;   Diabetes;   Hypercholesterolemia;   Hypertension
Intervention:   Device: ABI using QuantaFlo™
Sponsor:   St. Louis University
Recruiting - verified May 2017

Prevalence of Corneal Astigmatism Before Glaucoma Surgery in Chinese Patients With Primary Angle-closure Glaucoma

Conditions:   Glaucoma, Angle-Closure;   Astigmatism
Intervention:  
Sponsor:   Mingkai Lin
Not yet recruiting - verified May 2017

The eyeGuide: Improving Glaucoma Self-management With a Personalized Behavior Change Program

Conditions:   Medication Adherence;   Glaucoma
Intervention:   Behavioral: eyeGuide
Sponsors:   University of Michigan;   National Eye Institute (NEI);   Research to Prevent Blindness
Recruiting - verified May 2017

Illinois Workplace Wellness Study

Condition:   Employee Health and Well-being
Interventions:   Behavioral: Workplace Wellness Program;   Behavioral: Biometric Screening/HRA - No Compensation;   Behavioral: Biometric Screening/HRA - Moderate Compensation;   Behavioral: Biometric Screening/HRA - High Compensation;   Behavioral: Wellness Activities - Low Compensation;   Behavioral: Wellness Activities - High Compensation
Sponsors:   National Bureau of Economic Research, Inc.;   University of Illinois at Urbana-Champaign;   University of Chicago;   National Institutes of Health (NIH);   Robert Wood Johnson Foundation;   Abdul Latif Jameel Poverty Action Lab;   W.E. Upjohn Institute for Employment Research;   National Institute on Aging (NIA)
Active, not recruiting - verified May 2017

Newly Diagnosed Immune Thrombocytopenia Testing the Standard Steroid Treatment Against Combined Steroid & Mycophenolate

Condition:   Immune Thrombocytopenia
Interventions:   Drug: Mycophenolate Mofetil;   Drug: Prednisolone
Sponsors:   University Hospitals Bristol NHS Foundation Trust;   Cardiff University
Not yet recruiting - verified April 2017

Effects of a 4-week Raw, Plant-based Diet on Anthropometric and Cardiovascular Risk Factors

Conditions:   Hypertension;   Elevated Cholesterol;   Overweight and Obesity
Intervention:   Other: Dietary Intervention
Sponsors:   Texas Woman's University;   Montgomery Heart & Wellness
Completed - verified May 2017

Laminar Drainage Implant: Safety of a Novel Surgical Treatment for Refractory Glaucoma.

Conditions:   Glaucoma;   Blindness, Acquired;   End-Stage Glaucoma;   Glaucoma Traumatic
Intervention:   Device: Laminar drainage implant surgery.
Sponsor:   Federal University of Minas Gerais
Completed - verified May 2017

Study of SHP639 Eye Drops in Adults With High Eye Pressure or Primary Open-angle Glaucoma

Condition:   Ocular Hypertension, Primary Open-angle Glaucoma (POAG)
Interventions:   Drug: SHP639 (n=60);   Drug: Placebo Comparator (n=24)
Sponsor:   Shire
Recruiting - verified May 2017

The Effect of Conbercept Injection Through Different Routes for Neovascular Glaucoma

Condition:   Neovascular Glaucoma
Interventions:   Procedure: Intracameral injection;   Procedure: Intravitreal injection
Sponsor:   Second Affiliated Hospital of Xi'an Jiaotong University
Recruiting - verified May 2017

Project IMPACT: CHW Intervention

Condition:   Hypertension
Interventions:   Behavioral: CHW Intervention;   Behavioral: Wait List Control Group
Sponsor:   New York University School of Medicine
Recruiting - verified May 2017

Screening for Primary Aldosteronism in a Population of Patients With Hypertension

Conditions:   Primary Aldosteronism;   Hypertension;   Hypertension Secondary
Intervention:  
Sponsors:   Uppsala University;   Uppsala-Örebro Regional Research Council
Recruiting - verified April 2017

Assessment of Heparin Binding Protein for the Prediction of Severe Sepsis

Conditions:   Sepsis;   Septic Shock;   Sepsis With Acute Organ Dysfunction
Intervention:  
Sponsors:   Axis Shield Diagnostics Ltd;   Drexel University;   York Hospitals;   Jefferson Medical College of Thomas Jefferson University
Recruiting - verified May 2017

EPO-4-Rhesus: Role of Darbepoetin Alfa in Reducing Late Anaemia in Neonates With Red Blood Cell Alloimmunization After Intrauterine Transfusions

Conditions:   Erythroblastosis, Fetal;   Erythroblastosis Fetalis, Rh Disease;   Erythroblastosis Fetalis Due to RH Antibodies;   Erythroblastosis Fetalis Due to Isoimmunization
Intervention:   Drug: Darbepoetin Alfa
Sponsors:   Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research;   Leiden University Medical Center
Not yet recruiting - verified May 2017

Hookah Smoking, Carbon Monoxide, and Coronary Endothelial Function

Conditions:   Smoking;   Endothelial Dysfunction
Interventions:   Other: Charcoal hookah vs. e-coal hookah vs.Cigarette;   Drug: Carbon Monoxide inhalation vs. Room Air inhalation;   Other: Charcoal heated hookah vs.cigarette;   Drug: Charcoal heated hookah vs.cigarette after vitamin C or tadalafil
Sponsors:   Cedars-Sinai Medical Center;   National Institutes of Health (NIH);   National Institute on Drug Abuse (NIDA)
Not yet recruiting - verified May 2017

Effectiveness of a mHealth Intervention for the Treatment of Depression in People With Diabetes or Hypertension in Peru

Conditions:   Depression;   Diabetes;   Hypertension
Intervention:   Behavioral: CONEMO
Sponsors:   Universidad Peruana Cayetano Heredia;   University of Sao Paulo General Hospital;   National Institute of Mental Health (NIMH);   Northwestern University
Recruiting - verified May 2017

To Evaluate Real-world Safety, Effectiveness and Appropriate Use of Micatrio® Combination Tablets Treatment in Patients With Hypertension

Condition:   Hypertension
Intervention:   Drug: T80/A5/H12.5 FDC
Sponsor:   Boehringer Ingelheim
Recruiting - verified May 2017

The Prophet Trial - Pilot Study to Assess Safety and Efficacy of a Novel Atrial Flow Regulator (AFR) in Patients With Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Device: Occlutech AFR Device
Sponsor:   Occlutech International AB
Not yet recruiting - verified May 2017

Study to Compare Triple Therapy (Oral Treprostinil, Ambrisentan, and Tadalafil) With Dual Therapy (Ambrisentan, Tadalafil, and Placebo) in Subjects With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Oral Treprostinil;   Drug: Placebo
Sponsor:   United Therapeutics
Not yet recruiting - verified May 2017

A Phase 2/3 Trial of the Efficacy and Safety of Bardoxolone Methyl in Patients With Alport Syndrome - CARDINAL

Condition:   Alport Syndrome
Interventions:   Drug: Placebo Oral Capsule;   Drug: Bardoxolone Methyl
Sponsor:   Reata Pharmaceuticals, Inc.
Recruiting - verified May 2017

Melatonin in Pregnancy Compared to Non-pregnant

Condition:   Pregnancy Transient Hypertension
Intervention:  
Sponsors:   University of Aberdeen;   NHS Grampian
Completed - verified January 2017

Study of the Efficacy and Safety of DigiFab® in Antepartum Subjects With Severe Preeclampsia

Condition:   Severe Preeclampsia
Interventions:   Biological: Digoxin immune fab;   Other: Placebo
Sponsor:   Velo Bio, LLC
Recruiting - verified May 2017

A Clinical Trial to Evaluate the Pharmacokinetics and Safety/Tolerability of Fimasartan and Atorvastatin in Healthy Male Volunteers.

Condition:   Hypertension, Hyperlipidemia
Intervention:   Drug: Fimasartan, Atorvastatin
Sponsor:   Boryung Pharmaceutical Co., Ltd
Recruiting - verified January 2017

A Study to Compare the Pharmacokinetics and Safety of a Fixed Dose Combination of Fimasartan/Amlodipine/Rosuvastatin

Condition:   Hypertension, Hyperlipidemia
Intervention:   Drug: Fimasartan/Amlodipine combination drug, Rosuvastatin
Sponsor:   Boryung Pharmaceutical Co., Ltd
Active, not recruiting - verified January 2017

Pilot to Examine Risk and Feasibility of Remote Management of BP From CKD Through ESRD

Conditions:   Chronic Kidney Disease;   Bloodpressure;   Hypertension
Intervention:   Other: Strict blood pressure control
Sponsor:   University of California, San Francisco
Recruiting - verified May 2017

Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension

Conditions:   Hypotension, Orthostatic;   Hypertension;   Autonomic Nervous System Diseases
Interventions:   Drug: Yohimbine;   Drug: Melatonin
Sponsor:   Lawson Health Research Institute
Not yet recruiting - verified October 2016

Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe/Superimposed Preeclampsia

Condition:   Pregnancy
Intervention:   Drug: 17 OHPC
Sponsor:   Babbette Lamarca
Not yet recruiting - verified May 2017

Markers of Inflammation and Lung Recovery in ECMO Patients for PPHN

Condition:   Persistent Pulmonary Hypertension of the Newborn
Intervention:  
Sponsors:   University of Leicester;   University Hospitals, Leicester;   Heart Link Children's Charity;   British Heart Foundation
Recruiting - verified October 2016

A Comparison of Intermittent Intravenous Boluses of Phenylephrine and Norepinephrine to Prevent Spinal-induced Hypotension in Cesarean Deliveries

Condition:   Hypotension
Interventions:   Drug: Norepinephrine;   Drug: Phenylephrine
Sponsor:   Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Completed - verified May 2017

Effect of Background Noise on Sleep Quality

Condition:   Sleep Onset Insomnia
Intervention:   Device: NIghtingale (R) device for filtered white noise (Cambridge Sound Management, Waltham, MA)
Sponsor:   Brigham and Women's Hospital
Active, not recruiting - verified May 2017

Electronic-personalized Program for Obesity in Pregnancy to Improve Delivery

Conditions:   Obesity;   Pregnancy
Intervention:   Behavioral: ePPOP-ID program
Sponsors:   University Hospital, Lille;   Ministry of Health, France
Not yet recruiting - verified May 2017

Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Adempas (Riociguat, BAY63-2521);   Drug: Sildenafil;   Drug: Tadalafil
Sponsor:   Bayer
Recruiting - verified May 2017

Trial to Reduce Sitting Time in Postmenopausal Latina Women at Increased Risk for Heart Disease

Condition:   Sedentary Lifestyle
Interventions:   Device: ActivPAL inclinometer;   Behavioral: Phone counseling call: Breaking up sitting time;   Behavioral: In-person counseling: Breaking up sitting time;   Behavioral: Phone counseling call: Healthy living;   Other: Tools to prompt standing;   Behavioral: In-person counseling: Healthy living
Sponsors:   University of California, San Diego;   South Bay Latino Research Center;   San Ysidro Health Center;   San Diego State University
Recruiting - verified May 2017

Study of CS-3150 in Patients With Primary Aldosteronism

Condition:   Primary Aldosteronism
Intervention:   Drug: CS-3150
Sponsor:   Daiichi Sankyo Co., Ltd.
Active, not recruiting - verified May 2017

Emricasan, an Oral Caspase Inhibitor, in Subjects With Non-Alcoholic Steatohepatitis (NASH) Cirrhosis and Severe Portal Hypertension

Conditions:   Cirrhosis;   Portal Hypertension;   Non-alcoholic Steatohepatitis
Interventions:   Drug: Emricasan;   Drug: Placebo
Sponsor:   Conatus Pharmaceuticals Inc.
Recruiting - verified May 2017

MOMENTUM 3 Continued Access Protocol

Condition:   Advanced Refractory Left Ventricular Heart Failure
Intervention:   Device: HeartMate 3 LVAS
Sponsors:   St. Jude Medical;   Thoratec, LLC
Recruiting - verified May 2017

Study of CS-3150 Compared to Olmesartan in Patients With Essential Hypertension

Condition:   Essential Hypertension
Interventions:   Drug: CS-3150;   Drug: olmesartan medoxomil
Sponsor:   Daiichi Sankyo Co., Ltd.
Completed - verified May 2017

Non-interventional, Postauthorization Safety Study of Ventavis for Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Ventavis (Iloprost, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified May 2017

Integrated Primary Care for Diabetes and Cardiovascular Disease

Conditions:   Diabetes Mellitus;   Hypertension;   Heart Failure;   Ischemic Heart Disease;   Cerebrovascular Disease
Interventions:   Behavioral: Outreach education training;   Behavioral: No outreach education training
Sponsors:   University of Sao Paulo General Hospital;   University of Sao Paulo;   Santa Catarina Federal University;   University of Cape Town;   Federal University of Bahia;   Medical Research Council, South Africa;   University of East Anglia
Recruiting - verified January 2017

Open-label, Single Arm Trial of BI 695502 in Patients With Previously Untreated Metastatic Colorectal Cancer

Condition:   Colorectal Neoplasms
Interventions:   Drug: BI 695502;   Drug: chemotherapy
Sponsor:   Boehringer Ingelheim
Recruiting - verified May 2017

Pilot Study of the Safety and Efficacy of Anakinra in Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Anakinra
Sponsor:   Virginia Commonwealth University
Recruiting - verified May 2017

Detection of Atrial Fibrillation After Cardiac Surgery

Conditions:   Atrial Fibrillation;   Atrial Flutter;   C.Surgical Procedure; Cardiac;   Arrhythmias, Cardiac
Interventions:   Device: Medtronic SEEQ™ mobile cardiac telemetry system;   Other: Usual Care
Sponsor:   St. Michael's Hospital, Toronto
Recruiting - verified May 2017

High-Volume Plasma Exchange Versus Standard Medical Treatment in Patients With Acute Liver Failure

Condition:   Acute Liver Failure
Interventions:   Biological: High Volume Plasma Exchange;   Other: Management of cerebral edema/intracranial hypertension:;   Other: Transfer to Intensive Care Unit;   Drug: Prophylactic Antibiotics;   Other: Intubation of trachea;   Other: Administration of mannitol or 3% saline for severe elevation of Intra Cranial Pressure;   Other: Volume Replacement;   Other: Pressor Support;   Drug: N-acetyl-L-cysteine;   Other: Correction of metabolic parameters;   Dietary Supplement: Correction of nutrition
Sponsor:   Institute of Liver and Biliary Sciences, India
Recruiting - verified October 2016

Renoprotective Effects of Dapagliflozin in Type 2 Diabetes

Conditions:   Diabetes Mellitus, Type 2;   Diabetic Nephropathies
Interventions:   Drug: Dapagliflozin 10mg QD;   Drug: Gliclazide 30mg QD
Sponsors:   M.H.H. Kramer;   AstraZeneca
Recruiting - verified May 2017

Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension - CATALYST

Condition:   Connective Tissue Disease-Associated Pulmonary Arterial Hypertension
Interventions:   Drug: Placebo capsules;   Drug: Bardoxolone methyl capsules
Sponsor:   Reata Pharmaceuticals, Inc.
Recruiting - verified May 2017

The Influence of day-to Day BPV on Long-term Adverse Outcomes in Patients Ischemic Stroke

Condition:   Stroke
Intervention:  
Sponsor:   Zhu Shi
Completed - verified May 2017

A Study of the ReCor Medical Paradise System in Clinical Hypertension

Conditions:   Hypertension;   Vascular Diseases
Interventions:   Device: The Paradise® Renal Denervation Ultrasound System;   Device: Sham Procedure
Sponsor:   ReCor Medical, Inc.
Recruiting - verified May 2017

Postprandial Effects of a High Potassium Meal

Condition:   Hypertension
Interventions:   Other: High Potassium Meal;   Other: Low Potassium Meal
Sponsor:   Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Completed - verified May 2017

Increasing Potassium Intake in Hypertensive Individuals

Condition:   Hypertension
Intervention:   Other: High potassium diet
Sponsor:   Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Completed - verified May 2017

An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease;   Combined Pulmonary Fibrosis and Emphysema
Intervention:   Drug: Inhaled Treprostinil
Sponsor:   United Therapeutics
Enrolling by invitation - verified May 2017

Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease;   Combined Pulmonary Fibrosis and Emphysema
Interventions:   Drug: Inhaled Treprostinil;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting - verified May 2017

A Study Investigating Routine Practice of Chronic Thromboembolic Pulmonary Hypertension Management in EMEA Countries

Condition:   Hypertension, Pulmonary
Intervention:   Other: Standard of care
Sponsor:   Bayer
Recruiting - verified May 2017

Comparison of the Human Acellular Vessel (HAV) With ePTFE Grafts as Conduits for Hemodialysis

Conditions:   Renal Failure;   End Stage Renal Disease;   Hemodialysis;   Vascular Access
Interventions:   Biological: Human Acellular Vessel (HAV);   Device: ePTFE graft
Sponsors:   Humacyte, Inc.;   CTI Clinical Trial and Consulting Services
Recruiting - verified May 2017

Effects of Polyphenols Found in Pomegranate Juice on Postprandial Blood Glucose in Vivo

Condition:   Hyperglycaemia
Interventions:   Other: Control without pomegranate juice;   Other: Test with pomegranate juice
Sponsor:   University of Leeds
Completed - verified May 2017

The Use of Ambulatory Blood Pressure Monitors to Assess Angiotensin Converting Enzyme Inhibitors

Condition:   Hypertension, Resistant to Conventional Therapy
Interventions:   Drug: Equivalent dose enalapril;   Drug: Equivalent dose lisinopril
Sponsor:   Memorial Health University Medical Center
Recruiting - verified May 2017

Primary Ovarian Insufficiency, Polycystic Ovary Syndrome & the CardiOvascular Risk Profile

Condition:   Cardiovascular Diseases
Intervention:   Procedure: cardiovascular screening
Sponsors:   UMC Utrecht;   VU University Medical Center;   Erasmus Medical Center
Recruiting - verified May 2017

A Cross-sectional Study for the Determination of the Prevalence of Non-valvular Atrial Fibrillation Among Patients Diagnosed With Hypertension

Conditions:   Hypertension;   Atrial Fibrillation
Intervention:   Other: Standard of care
Sponsor:   Bayer
Completed - verified May 2017

Treating to Reduce Albuminuria and Normalize Hemodynamic Function in Focal ScLerosis With dApagliflozin Trial Effects

Condition:   Focal Segmental Glomerulosclerosis
Intervention:   Drug: Dapagliflozin
Sponsors:   University Health Network, Toronto;   AstraZeneca;   University of Toronto;   Toronto General Hospital
Recruiting - verified May 2017

A Study to Understand the Treatment Patterns in Patients With Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension During a Switch of Treatment to Adempas in Real-life Clinical Practice

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsor:   Bayer
Completed - verified May 2017

Atorvastatin Effectiveness and Safety in Cardiology Patients in Real World Setting

Condition:   Coronary Artery Disease, Hypercholesterolemia, Hypertension
Intervention:   Other: No intervention
Sponsor:   Pfizer
Recruiting - verified May 2017

Optic Nerve Sheath Diameter and Intracranial Pressure (ICP) in Children

Condition:   Intracranial Hypertension
Intervention:   Procedure: ultrasound
Sponsor:   Anna Rominger
Withdrawn - verified May 2017

Latanoprost Preserved Versus Unpreserved: Effect on Tear Film Thickness as Measured With OCT

Conditions:   Glaucoma;   Ocular Hypertension
Interventions:   Drug: Preservative-free latanoprost 50µg/ml;   Drug: Preserved latanoprost 0.005%
Sponsor:   Medical University of Vienna
Recruiting - verified May 2017

Role of Biomarkers in Predicting Contrast-induced Acute Kidney Injury in Critically Ill Patients

Condition:   Acute Kidney Injury
Intervention:  
Sponsor:   Sanjay Gandhi Postgraduate Institute of Medical Sciences
Completed - verified May 2017

Study Comparing Lutonix AV Drug Coated Balloon vs Standard Balloon for Treatment of Dysfunctional AV Fistulae

Condition:   Arteriovenous Fistula
Interventions:   Combination Product: Lutonix DCB;   Device: Standard Balloon Angioplasty Catheter
Sponsor:   C. R. Bard
Active, not recruiting - verified May 2017

On-Line Intervention For Promoting Healthy Habits And Weight Loss In Hypertensive Patients

Condition:   Obesity
Intervention:   Behavioral: Lifestyle on-line intervention
Sponsors:   Universitat Jaume I;   University of Valencia;   Cardenal Herrera University
Completed - verified May 2017

Midodrine for Ischemic Stroke With Penumbra

Condition:   Stroke
Intervention:   Drug: Midodrine
Sponsor:   University of Utah
Withdrawn - verified May 2017

Check and Support -Enhancing the Treatment of Hypertension in Outpatient Care, a Multicenter Study

Conditions:   Hypertension;   Blood Pressure;   Patient Compliance;   Patient Adherence;   Medication Adherence
Interventions:   Behavioral: IMB model-based initiation of antihypertensive medication;   Behavioral: Tailored SMS-text message support;   Behavioral: Usual care
Sponsors:   Kuopio University Hospital;   Health Centre of Jyväskylä Cooperation Area;   Central Finland Hospital District;   Occupational Health Care Työterveys Aalto;   Mehiläinen Jyväskylä Occupational health services;   Northern Savo Hospital District
Active, not recruiting - verified May 2017

Getting Older Adults OUT-of -Doors

Condition:   Older Adults With Decreased Outdoor Walking Ability
Interventions:   Other: GO-OUT program;   Other: Task-oriented outdoor walking workshop
Sponsors:   University of Manitoba;   University of Toronto;   McGill University;   University of Alberta
Completed - verified May 2016

REPAIR: Right vEntricular Remodeling in Pulmonary ArterIal hypeRtension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Recruiting - verified May 2017

Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone

Conditions:   Alcoholic Hepatitis;   Alcoholic Liver Disease
Interventions:   Drug: Amoxicillin;   Drug: Placebo;   Drug: Prednisolone
Sponsors:   University Hospital, Lille;   Ministry of Health, France
Recruiting - verified May 2017

Phase III Trial BI 695502 Plus Chemotherapy vs. Avastin® Plus Chemotherapy in Patients With Lung Cancer

Condition:   Carcinoma, Non-Small-Cell Lung
Interventions:   Drug: Chemotherapy;   Drug: BI 695502;   Drug: bevacizumab;   Drug: Chemotherapy
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified May 2017

Warfarin Prevents Portal Vein Thrombosis in Patients After Laparoscopic Splenectomy and Azygoportal Disconnection

Conditions:   Cirrhosis;   Hypertension;   Status;Splenectomy;   Venous Thrombosis
Interventions:   Drug: Warfarin;   Drug: Dipyridamole;   Drug: Aspirin;   Drug: Low Molecular Weight Heparin
Sponsor:   Yangzhou University
Recruiting - verified May 2017

Impact of Weight Loss After a Bypass Surgery on Renal Hemodynamic Under Stress Conditions

Conditions:   Obesity;   Bariatric Surgery;   Blood Pressure
Intervention:   Procedure: bariatric surgery (gastric bypass)
Sponsor:   Centre Hospitalier Universitaire Vaudois
Recruiting - verified August 2015

MOMENTUM 3 IDE Clinical Study Protocol

Condition:   Advanced Refractory Left Ventricular Heart Failure
Interventions:   Device: HeartMate 3 LVAS;   Device: HeartMate II LVAS
Sponsors:   Thoratec Corporation;   St. Jude Medical
Active, not recruiting - verified May 2017

24 Week Efficacy and Safety Study of Empagliflozin (BI 10773) in Hypertensive Black/African American Patients With Type 2 Diabetes Mellitus and Hypertension

Conditions:   Diabetes Mellitus, Type 2;   Hypertension
Interventions:   Drug: Empagliflizon low dose;   Drug: placebo;   Drug: Empagliflizon high dose
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified May 2017

Patients With Pulmonary Hypertension or Interstitial Lung Disease at Altitude - Effect of Oxygen on Breathing and Sleep

Conditions:   Precapillary Pulmonary Hypertension;   Interstitial Lung Disease
Interventions:   Behavioral: Moderate altitude sojourn;   Behavioral: Low altitude sojourn;   Drug: Oxygen;   Drug: Sham oxygen (room air)
Sponsor:   University of Zurich
Recruiting - verified May 2017

A Comparison of Sedative Drugs for Conscious Sedation During Ultrasound Guided Transbronchial Needle Aspiration

Condition:   Endobronchial Ultrasound Guided Transbronchial Needle Aspiration
Interventions:   Drug: midazolam;   Drug: Dexmedetomidine
Sponsor:   Seoul National University Hospital
Completed - verified May 2017

Study of Ranolazine in the Treatment of Pulmonary Hypertension Associated With Diastolic Left Ventricular Dysfunction

Conditions:   Pulmonary Hypertension;   Diastolic Left Ventricular Dysfunction
Intervention:   Drug: Ranolazine
Sponsors:   Boston University;   Gilead Sciences
Completed - verified May 2017

Study 2: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients

Condition:   Hypertension
Interventions:   Drug: Minocycline Group;   Other: Placebo Group
Sponsors:   University of Florida;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified May 2017

Pregnancy Outcomes in Women With Recurrent Pregnancy Loss Treated With Low Dose Aspirin and Unfractionated Heparin

Condition:   Recurrent Pregnancy Loss
Intervention:   Drug: Heparin
Sponsor:   Benha University
Completed - verified May 2017

Controlled Education Of Patients After Stroke

Conditions:   Stroke;   Hypertension
Intervention:   Other: optimised follow-up
Sponsors:   University Hospital, Lille;   Ministry of Health, France
Recruiting - verified May 2017

Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH )

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Recruiting - verified May 2017

Comprehensive Lifestyle Modification for Patients With Hypertension and Metabolic Syndrome: a Multicenter Randomized Controlled Trial

Conditions:   Hypertension;   Metabolic Syndrome
Interventions:   Behavioral: Comprehensive Lifestyle Modification;   Behavioral: DASH
Sponsors:   Universität Duisburg-Essen;   Kliniken Essen-Mitte;   Immanuel Hospital Berlin, Berlin, Germany;   Charite University, Berlin, Germany;   University of Witten/Herdecke
Completed - verified May 2017

EXPERT, EXPosurE Registry RiociguaT in Patients With Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat(BAY63-2521)
Sponsor:   Bayer
Recruiting - verified May 2017

Aldosterone, Microvascular Function and Salt-sensitivity

Conditions:   Abdominal Obesity;   Metabolic Syndrome;   Sodium-sensitivity;   Insulin Resistance;   Hypertension
Interventions:   Dietary Supplement: Low-sodium diet;   Dietary Supplement: High-sodium diet
Sponsor:   Maastricht University Medical Center
Completed - verified May 2017

Effects of Oral Sildenafil on Mortality in Adults With PAH

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: sildenafil citrate;   Drug: sildenafil citrate;   Drug: sildenafil citrate
Sponsor:   Pfizer
Recruiting - verified May 2017

Monotherapy-Controlled Study of Nifedipine Gastrointestinal Therapeutic System and Candesartan Cilexetil in Combination in Subjects With Essential Hypertension Inadequately Controlled on Candesartan Cilexetil

Condition:   Hypertension
Interventions:   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106);   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106);   Drug: Candesartan Cilexetil;   Drug: Candesartan matching placebo;   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106) 30/16mg matching placebo;   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106)
Sponsor:   Bayer
Withdrawn - verified May 2017

Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Active, not recruiting - verified May 2017

Essential Hypotension and Allostasis Registry

Conditions:   Blood Pressure;   Depression;   Panic Attack;   Fibromyalgia;   POTS;   Inappropriate Sinus Tachycardia;   Coronary Heart Disease;   Acute Coronary Syndrome (ACS);   Acute Myocardial Infarction (AMI);   Cerebrovascular Disease (CVD);   Transient Ischemic Attack (TIA);   Atrial Fibrillation;   Diabetes Mellitus;   Cancer;   Systolic Heart Failure;   Diastolic Heart Failure;   Chronic Fatigue Syndrome;   Syncope;   Vasovagal Syncope
Intervention:  
Sponsor:   CES University
Recruiting - verified May 2017

PC Protocol: Preconceptional Screening

Condition:   Infertility
Intervention:  
Sponsor:   UMC Utrecht
Recruiting - verified May 2017

Blood Flow Regulation in Glaucoma

Condition:   Glaucoma
Intervention:   Other: Isometric exercise
Sponsor:   Medical University of Vienna
Recruiting - verified May 2017

Sildenafil Therapy For Subjects Who Derive Clinical Benefit From Continued Treatment With Sildenafil

Condition:   Pulmonary Arterial Hypertension (PAH)
Intervention:   Drug: sildenafil
Sponsor:   Pfizer
Available - verified May 2017

Determine the Frequency of a HTPPE in 5 Years (± on 1 Year) After a First Episode of Idiopathic Pulmonary Embolism.

Conditions:   HTPPE;   Idiopathic Pulmonary Embolism
Intervention:   Other: HTPPE
Sponsor:   University Hospital, Brest
Recruiting - verified May 2017

Aldosterone Antagonism and Microvascular Function

Conditions:   Abdominal Obesity Metabolic Syndrome;   Insulin Resistance;   Hypertension
Interventions:   Drug: Eplerenone;   Other: Placebo
Sponsor:   Maastricht University Medical Center
Recruiting - verified May 2017

One-Day Acceptance and Commitment Training Intervention in Primary Care Patients

Conditions:   Mood Disorders;   Hypertension;   Diabetes;   Hypercholesterolemia
Intervention:   Behavioral: Acceptance and Commitment Therapy plus Illness Management
Sponsor:   Lilian N. Dindo
Completed - verified May 2017

A Study in Maintenance Kidney Transplant Recipients Following Conversion to Nulojix® (Belatacept)-Based

Condition:   Kidney Transplantation
Interventions:   Drug: Belatacept;   Drug: Tacrolimus;   Drug: Cyclosporine
Sponsor:   Bristol-Myers Squibb
Recruiting - verified May 2017

Renal Response to Lower Body Negative Pressure in Pre-hypertensive States

Conditions:   Hypertension;   Obesity;   White Coat Hypertension;   Resistant Hypertension
Interventions:   Other: Lower body negative pressure (LBNP);   Drug: Candesartan cilexetil
Sponsors:   PD Dr. Grégoire Wuerzner;   Swiss National Science Foundation
Completed - verified May 2017

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified May 2017

REMEDIES4D: REdesigning MEDication Intensification Effectiveness Study for Diabetes

Condition:   Type 2 Diabetes
Intervention:   Other: Treatment Algorithms
Sponsors:   University of Pittsburgh;   American Diabetes Association
Completed - verified May 2017

Post-Authorisation Safety Cohort Observation of RetacritTM (Epoetin Zeta) Administered Subcutaneously for the Treatment of Renal Anaemia

Conditions:   Renal Anemia;   Pregnancy;   Lactation
Intervention:  
Sponsors:   Pfizer;   Hospira, now a wholly owned subsidiary of Pfizer
Recruiting - verified May 2017

Simplified Cardiovascular Management Study

Condition:   Cardiovascular Disease
Intervention:   Other: Simplified cardiovascular disease management
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified August 2014

Genetic Mechanisms in Human Hypertension

Condition:   Hypertension
Interventions:   Drug: Para-aminohippuric Acid;   Drug: Angiotensin II;   Drug: Norepinephrine
Sponsor:   Brigham and Women's Hospital
Active, not recruiting - verified May 2017

Impact of Controlling Vascular Risk Factors on the Progression of Alzheimer's Disease

Conditions:   Alzheimer's Disease;   Cardiovascular Risk Factors
Interventions:   Other: optimal care of VRF;   Other: standard care
Sponsors:   University Hospital, Lille;   Ministry of Health, France
Recruiting - verified May 2017

Vascular Dysfunction in Diabetes: Genes and Hormones

Condition:   Diabetes Mellitus
Interventions:   Drug: Para-aminohippuric Acid;   Drug: Angiotensin II;   Drug: Norepinephrine
Sponsor:   Brigham and Women's Hospital
Active, not recruiting - verified May 2017

Drug Use Investigation for FLOLAN (Epoprostenol) Injection 0.5mg・1.5mg

Condition:   Cardiovascular Disease
Intervention:   Drug: Epoprostenol
Sponsor:   GlaxoSmithKline
Completed - verified May 2017

Biomarkers in Tissue Samples From Patients With Breast Cancer Treated With Bevacizumab

Condition:   Breast Cancer
Interventions:   Genetic: DNA analysis;   Genetic: gene expression analysis;   Genetic: polymorphism analysis;   Genetic: protein expression analysis;   Other: immunohistochemistry staining method;   Other: laboratory biomarker analysis
Sponsors:   ECOG-ACRIN Cancer Research Group;   National Cancer Institute (NCI)
Completed - verified May 2017

Genetic Mechanisms in Human Hypertension Renin-angiotensin-aldosterone System (RAAS) Inhibition Study

Condition:   Hypertension
Intervention:   Drug: Lisinopril, Atenolol
Sponsors:   Brigham and Women's Hospital;   University of Utah
Active, not recruiting - verified May 2017

BAY63-2521 - Long-term Extension Study in Patients With Chronic Thromboembolic Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsor:   Bayer
Active, not recruiting - verified May 2017

A Study of Oseltamivir (Tamiflu) for Treatment of Influenza in Immunocompromised Participants.

Condition:   Influenza, Human
Interventions:   Drug: oseltamivir;   Other: placebo
Sponsor:   Hoffmann-La Roche
Completed - verified May 2017

VALIDATE Valsartan and Supportive Measures - Impact on Drug Adherence of Treated Hypertensive Patients

Condition:   Hypertension
Intervention:   Behavioral: Set of supportive tools/measures vs. standard care
Sponsor:   Novartis
Completed - verified May 2017

Efficacy and Safety of the Combination of Valsartan Plus Amlodipine in Hypertensive Patients Not Adequately Responding to the Combination Therapy With Ramipril Plus Felodipine

Condition:   Hypertension
Intervention:   Drug: valsartan + amlodipine
Sponsor:   Novartis
Completed - verified May 2017

Reference Values for Plasma Catechols

Conditions:   Healthy Volunteers;   Normal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 10, 2017

Clinical Study to Evaluate the Efficacy and Safety of Aliskiren Alone and in Combination With Hydrochlorothiazide in Patients With Essential Hypertension.

Condition:   Hypertension
Intervention:   Drug: aliskiren
Sponsor:   Novartis
Completed - verified May 2017

A Clinical Study to Evaluate the Safety and Efficacy of Aliskiren Alone and in Combination With Ramipril in Hypertensive, Diabetic Patients.

Condition:   Hypertension, Diabetes Mellitus
Intervention:   Drug: aliskiren
Sponsor:   Novartis
Completed - verified May 2017

A Clinical Study to Compare an Aliskiren Based Hypertensive Regimen With a Ramipril Based One Followed by a Randomized Withdrawal.

Condition:   Hypertension
Intervention:   Drug: aliskiren
Sponsor:   Novartis
Completed - verified May 2017

A Clinical Study to Evaluate the Safety and Efficacy of the Combination of Aliskiren and Amlodipine in Hypertensive Non Responders Patients

Condition:   Hypertension
Intervention:   Drug: aliskiren
Sponsor:   Novartis
Completed - verified May 2017

VALID: Study to Compare the Reduction of Predialysis Systolic Blood Pressure With Valsartan Compared to Irbesartan in Patients With Mild to Moderate Hypertension on Long-term Hemodialysis

Condition:   Hypertension
Interventions:   Drug: valsartan;   Drug: irbesartan
Sponsor:   Novartis
Completed - verified May 2017

Efficacy and Safety of Valsartan/Amlodipine Combination in Hypertensive Patients Not Controlled With Valsartan Alone

Condition:   Hypertension
Intervention:   Drug: valsartan/amlodipine
Sponsor:   Novartis
Completed - verified May 2017

Efficacy and Safety of Valsartan/Amlodipine Combination in Hypertensive Patients Not Controlled With Amlodipine Alone

Condition:   Hypertension
Intervention:   Drug: valsartan/amlodipine
Sponsor:   Novartis
Completed - verified May 2017

VALERIA: Valsartan in Combination With Lisinopril in Hypertensive Patients With Microalbuminuria

Condition:   Hypertension
Interventions:   Drug: valsartan;   Drug: lisinopril
Sponsor:   Novartis
Completed - verified May 2017

Safety and Efficacy of Aliskiren When Added to Standardized Losartan and Optimal Antihypertensive Therapy in Patients With Hypertension, Type 2 Diabetes and Proteinuria

Condition:   Diabetic Nephropathy
Intervention:   Drug: aliskiren
Sponsor:   Novartis Pharmaceuticals
Completed - verified May 2017

Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia

Conditions:   Pulmonary Hypertension;   Sickle Cell Anemia;   Sickle Cell Disease
Intervention:  
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified May 16, 2017