High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Deep Learning Radiomics of MR Imaging for Clinically Significant Portal Hypertension in Cirrhosis (CHESS1802)

Condition:   Hypertension, Portal
Interventions:   Procedure: Transjugular HVPG measurement;   Procedure: MR imaging
Sponsors:   Nanfang Hospital of Southern Medical University;   Zhongda Hospital, Medical School of Southeast University;   Beijing 302 Hospital;   Affiliated Lishui Hospital of Zhejiang University;   Shandong Provincial Hospital;   Xingtai People's Hospital;   The First Hospital of Zhengzhou University;   Shanghai Public Health Clinical Center, Fudan University;   LanZhou University;   Shunde Hospital, Southern Medical University
Recruiting

24-hour Ambulatory Blood Pressure Monitoring in Patients With Blood Pressure Above Thresholds in General Practice

Conditions:   Hypertension;   Blood Pressure Monitoring, Ambulatory;   Primary Health Care
Intervention:   Device: 24-hour Ambulatory Blood Pressure Monitoring (ABPM)
Sponsors:   University of Burgundy;   Association pour le Développement de la Recherche en Médecine Générale (ADRMG);   Département de Médecine Générale de Dijon (DMG)
Recruiting

Prevalence, Risk Factors, and Prognostic Factors of Intraabdominal Hypertension and Abdominal Compartment Syndrome in Critically Ill Surgical Patients in Ramathibodi Hospital

Conditions:   Intraabdominal Hypertension;   Abdominal Compartment Syndrome
Intervention:   Diagnostic Test: Intraabdominal pressure monitoring
Sponsor:   Ramathibodi Hospital
Not yet recruiting

Hypertension Management in Young Adults Personalised by Echocardiography and Clinical Outcome.

Condition:   Hypertension
Intervention:   Diagnostic Test: Echocardiography scan
Sponsor:   University of Oxford
Recruiting

Decompressive Craniectomy for Severe Traumatic Brain Injury in Children With Refractory Intracranial Hypertension

Condition:   Hypertension Intracranial
Intervention:   Procedure: decompressive craniectomy
Sponsor:   Fondation Lenval
Not yet recruiting

Trial of Oral Melatonin in Elevated Blood Pressure

Condition:   Elevated Blood Pressure
Interventions:   Drug: Placebo oral capsule/placebo comparator;   Drug: Melatonin/experimental
Sponsor:   Tehran University of Medical Sciences
Not yet recruiting

Sildenafil in Hemodialysis Patients With Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Hemodialysis Complication
Interventions:   Drug: Sildenafil;   Other: Placebo
Sponsor:   Ain Shams University
Recruiting

Effects of Ground-based Walking Training in Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Other: Ground-based walking training
Sponsor:   Istanbul University
Enrolling by invitation

The Risk of Hypertension Associated With Oral Glucocorticoids in Chronic Inflammatory Diseases

Condition:   Hypertension
Intervention:   Drug: Glucocorticoids
Sponsor:   University of Leeds
Completed

Disclosure of Genetic Risk for Salt Sensitivity

Condition:   Salt-sensitive Hypertension
Intervention:   Behavioral: Dietary advice
Sponsor:   St Mary's University College
Not yet recruiting

Renal Sympathetic Denervation From the Adventitia on Resistant Hypertension(RSDARH)

Condition:   Resistant Hypertension
Intervention:   Device: Radiofrequency ablation instruments
Sponsor:   Henan Institute of Cardiovascular Epidemiology
Recruiting

Safety and Efficacy of SPH3127 on Treating Mild-moderate Essential Hypertension Patients

Condition:   Hypertension,Essential
Interventions:   Drug: SPH3127 tablet Dose 1;   Drug: SPH3127 tablet Dose 2;   Drug: SPH3127 tablet Dose 3;   Drug: SPH3127 tablet Placebo
Sponsors:   Shanghai Pharmaceuticals Holding Co., Ltd;   R&G Pharma Studies Co.,Ltd.
Not yet recruiting

The Effect of Household-based Screening on Blood Pressure Changes in South Africa

Conditions:   Hypertension;   Blood Pressure
Intervention:   Other: Household blood pressure screening with care encouragement
Sponsors:   Till Bärnighausen;   Emory University
Completed

Chickasaw Healthy Eating Environments Research Study

Conditions:   Blood Pressure;   Body Weight
Intervention:   Behavioral: Packed Promise for a Healthy Heart
Sponsors:   University of Oklahoma;   The Chickasaw Nation;   Washington State University
Recruiting

A Clinical Study to Evaluate the Efficacy and Safety of CKD-351

Conditions:   Primary Open-angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: CKD-351;   Drug: Latanoprost;   Drug: D930;   Drug: Placebo of CKD-351;   Drug: Placebo of D930
Sponsor:   Chong Kun Dang Pharmaceutical
Not yet recruiting

Targeting of UnControlled Hypertension in Emergency Department

Conditions:   Hypertension;   Cardiovascular Diseases;   Vascular Diseases
Interventions:   Other: HTN Educational Video;   Other: Visual Echocardiogram Image Clips;   Other: Mobile Health and Remote BP monitoring;   Other: Post-Acute Care HTN Transition consultation (PACHT-c)
Sponsor:   University of Illinois at Chicago
Not yet recruiting

B'More for a Peaceful Motherhood Hypertension Control Study

Condition:   Hypertension
Interventions:   Behavioral: High blood pressure management education;   Behavioral: Home blood pressure measurement
Sponsor:   University of Maryland
Not yet recruiting

Isometric Hand Grip Training in Obstructive Sleep Apnea (OSA)

Conditions:   Obstructive Sleep Apnea;   Hypertension
Interventions:   Other: Hand grip isometric contraction;   Other: Control
Sponsor:   University of Pernambuco
Recruiting

Vascular Functions in Myeloma Patients During Anti-tumor Therapy

Conditions:   Cardiooncology;   Myeloma;   Endothelial Dysfunction
Intervention:   Diagnostic Test: Flow mediated dilation
Sponsor:   University Hospital, Essen
Not yet recruiting

A FAMILY Program for Childhood Overweight and Obesity

Condition:   Overweight and Obesity
Intervention:   Behavioral: Behavioral intervention
Sponsor:   National Taiwan University Hospital
Recruiting

Counter-referral System Improvement Collaborative

Conditions:   Cardiovascular Diseases;   Quality Improvement
Intervention:   Behavioral: Improvement cycle
Sponsors:   Institute for Clinical Effectiveness and Health Policy;   Ministry of Public Health, Argentina
Recruiting

IL-1 Signal Inhibition in Alcoholic Hepatitis (ISAIAH)

Condition:   Alcoholic Hepatitis
Interventions:   Drug: Canakinumab 150mg/ml solution for injection;   Drug: Placebo
Sponsors:   Imperial College London;   Novartis Pharmaceuticals
Recruiting

Adrenergic Blockers for Cardiac Changes in Early Parkinson's Disease

Conditions:   REM Sleep Behavior Disorder;   Pre-motor Parkinson Disease;   Symptomatic Parkinson Disease
Intervention:   Drug: Carvedilol
Sponsor:   Michele Tagliati, MD
Not yet recruiting

Sleep Apnea After Extubation

Condition:   Sleep Apnea
Intervention:   Device: Respiratory polygraphy
Sponsor:   Seoul National University Hospital
Active, not recruiting

Clinical and Microbiological Relationships Between Periodontitis and Abdominal Aorta Aneurism: an Case Control Study

Conditions:   Abdominal Aorta Aneurism;   Periodontitis;   Dentulous
Intervention:   Other: cross sectional
Sponsors:   University Hospital of Liege;   KU Leuven
Completed

Calcium Administration in Cardiac Surgery

Conditions:   Cardiac Surgery;   Cardiopulmonary Bypass
Interventions:   Drug: Calcium Chloride;   Drug: 0.9% Sodium Chloride
Sponsors:   Meshalkin Research Institute of Pathology of Circulation;   Università Vita-Salute San Raffaele
Not yet recruiting

A Mechanistic Randomized Controlled Trial on the Cardiovascular Effect of Berberine

Condition:   Cardiovascular Risk Factor
Interventions:   Drug: Berberine;   Drug: Placebo
Sponsors:   The University of Hong Kong;   Food and Health Bureau, Hong Kong
Not yet recruiting

Effects of Respiratory Muscle Training in Obese Women

Conditions:   Inadequate or Impaired Respiratory Function;   Diabetes;   Hypertension
Intervention:   Procedure: Inspiratory muscle training
Sponsor:   Universidade Metodista de Piracicaba
Not yet recruiting

Collection of Whole Blood Samples for the Evaluation of Preeclampsia (Pre-E) Biomarkers From Pregnant Women

Conditions:   Pre-Eclampsia;   Hypertension;   Proteinuria in Pregnancy;   Thrombocytopenia;   Renal Insufficiency;   Impaired Liver Function;   Pulmonary Edema;   Headache;   Visual Impairment
Intervention:   Other: Non-interventional study
Sponsor:   Progenity, Inc.
Recruiting

Dexmedetomidine for Prolonged Sedation in PICUs

Condition:   Prolonged Sedation
Intervention:   Drug: Dexmedetomidine
Sponsors:   Azienda Ospedaliera di Padova;   Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola Malpighi
Recruiting

Exercise Intolerance in Heart Failure

Condition:   Heart Failure With Normal Ejection Fraction
Intervention:  
Sponsors:   Johns Hopkins University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Minimally Invasive Detection of a Sleep Apnoea

Conditions:   Sleep Disorder; Breathing-Related;   Cardiovascular Diseases;   Cardiovascular Risk Factor;   Cardiovascular Complication
Intervention:   Device: Kinocardiography unintrusive recording
Sponsor:   Erasme University Hospital
Enrolling by invitation

His Bundle Pacing Registry

Conditions:   Bradycardia;   Sinus Node Dysfunction;   Heart Block;   Syncope;   Cardiomyopathies;   Ventricular Tachycardia;   Heart Failure
Intervention:   Device: His bundle pacing (HBP) device implant
Sponsor:   St. Jude Medical
Recruiting

The Correlation Between Iodine and Selenium Status in Pregnancy and Risk of Thyroid Disease

Conditions:   Iodine Excess in Pregnancy;   Selenium Excess in Pregnancy;   Iodine Deficiency in Pregnancy;   Selenium Deficiency in Pregnancy
Intervention:   Other: Not applicable (for observational studies)
Sponsor:   Rongrong Li
Not yet recruiting

Prevalence of Chronic Thromboembolic Pulmonary Hypertension After Acute Pulmonary Embolism : (Preva-CTEPH)

Conditions:   Chronic Thromboembolic Pulmonary Hypertension (CTEPH);   Pulmonary Embolism
Intervention:   Diagnostic Test: Study population
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Merck Sharp & Dohme Corp.
Recruiting

A Study to Investigate the Effect of Extracorporeal Shockwave Lithotripsy on Hypertension

Conditions:   Hypertension;   Renal Stone
Intervention:   Procedure: Extracorporeal shock wave lithotripsy
Sponsor:   Chinese University of Hong Kong
Not yet recruiting

Serum Biomarkers for Portal Hypertension in Cirrhosis (Pan-CHESS1802)

Condition:   Hypertension, Portal
Intervention:   Procedure: HVPG measurement
Sponsors:   Nanfang Hospital of Southern Medical University;   Beijing YouAn Hospital;   Shandong Provincial Hospital;   Beijing Shijitan Hospital;   Beijing Friendship Hospital;   Xingtai People's Hospital;   Beijing 302 Hospital
Recruiting

Propranolol, Carvedilol and Rosuvastatin in the Prevention of Variceal Bleeding in Cirrhotic Portal Hypertension

Conditions:   Cirrhosis;   Portal Hypertension;   Variceal Hemorrhage
Interventions:   Drug: Propranolol;   Drug: Carvedilol;   Drug: Rosuvastatin;   Drug: Placebo
Sponsor:   Universidade Federal do Rio de Janeiro
Recruiting

Nicardipine and Labetalol Effects on Cerebral Hemodynamics in Preeclampsia

Condition:   Preeclampsia Severe
Intervention:   Diagnostic Test: optic nerve sheath measurement and transcranial doppler
Sponsor:   Hopital Antoine Beclere
Recruiting

Diagnostic Efficacy of CNN in Differentiation of Visual Field

Condition:   Diagnositic Efficacy of Deep Convolutional Neural Network in Differentiation of Glaucoma Visual Field From Non-glaucoma Visual Field
Intervention:  
Sponsor:   Sun Yat-sen University
Recruiting

Measurement of the Effect of Gingko Biloba Extract on Ocular and Nailfold Blood-flow in NTG

Condition:   Normal Tension Glaucoma
Interventions:   Dietary Supplement: Gingko Baloba;   Other: Placebo
Sponsor:   Robert Ritch, MD, LLC.
Recruiting

A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx, an Antisense Inhibitor Administered Subcutaneously to Hypertensive Subjects With Controlled Blood Pressure

Condition:   Mild Hypertension
Interventions:   Drug: IONIS-AGT-LRx;   Drug: Placebo
Sponsor:   Ionis Pharmaceuticals, Inc.
Recruiting

Description of the Evolution of Plasma and Urinary Concentrations of Iohexol in a Cirrhotic Patient Population

Condition:   Cirrhosis Renal
Intervention:   Drug: Iohexol Inj 300 MG/ML
Sponsor:   University Hospital, Limoges
Not yet recruiting

Clonidine as Adjunct to Morphine for Neonatal Abstinence Syndrome

Condition:   Neonatal Abstinence Syndrome
Interventions:   Drug: Clonidine;   Drug: Placebo
Sponsor:   Hennepin County Medical Center, Minneapolis
Recruiting

Effects of Preoperative Operating Room Environment Presentation in Hypertensive Patients

Conditions:   Hypertension;   Anxiety;   Blood Pressure
Intervention:   Behavioral: Group IORE
Sponsor:   Yuzuncu Yıl University
Completed

A Phase III Study Assessing the Efficacy and Safety of DE-117 Ophthalmic Solution Compared With Timolol Maleate Ophthalmic Solution 0.5% in Subjects With Glaucoma or Ocular Hypertension - Spectrum 4 Study

Condition:   Glaucoma and Ocular Hypertension
Interventions:   Drug: DE-117 Ophthalmic Solution;   Drug: Timolol Maleate Ophthalmic Solution 0.5%
Sponsor:   Santen Inc.
Recruiting

Corticosteroid Treatment in the Acute Phase of Caustic Ingestion Management

Conditions:   Caustic Esophageal Injury;   Esophageal Stenosis;   Pharyngeal Stenosis
Interventions:   Drug: Methylprednisolone;   Other: Placebo
Sponsor:   Assistance Publique - Hôpitaux de Paris
Not yet recruiting

Comparison of Efficacy and Safety of Mitomycin and Aflibercept Used to Support Primary Trabeculectomy.

Conditions:   Eye Diseases;   Optic Nerve Damage;   Glaucoma Surgery
Interventions:   Drug: Aflibercept;   Drug: Mitomycin
Sponsor:   Medical University of Lublin
Active, not recruiting

A Study of the Efficacy and Safety of Relacorilant

Condition:   Cushing Syndrome
Interventions:   Drug: Relacorilant;   Other: Placebo
Sponsor:   Corcept Therapeutics
Recruiting

Tocotrienols for Obesity of Postmenopausal Women

Conditions:   Obesity;   Postmenopausal Women
Interventions:   Drug: placebo softgel;   Drug: DeltaGold® Tocotrienol 70%
Sponsor:   Texas Tech University Health Sciences Center
Not yet recruiting

Comparison of Tandospirone, Amlodipine and Their Combination in Adults With Hypertension and Anxiety

Conditions:   Hypertension;   Anxiety
Interventions:   Drug: Tandospirone + Amlodipine;   Drug: Tandospirone placebo + Amlodipine;   Drug: Tandospirone + Amlodipine placebo;   Drug: Tandospirone placebo + Amlodipine placebo
Sponsor:   Chongqing Medical University
Not yet recruiting

Crystalloid Versus Colloid Rapid Co-load for Cesarean Delivery Under Spinal Anesthesia

Conditions:   Pregnancy;   Cesarean Delivery;   Hypotension
Interventions:   Other: Crystalloid;   Other: Colloid
Sponsor:   Seoul National University Hospital
Recruiting

Longitudinal Observation of Insulin Requirements and Sensor Use in Pregnancy

Conditions:   Type 1 Diabetes Mellitus;   Pregnancy in Diabetics
Intervention:   Device: Dexcom G6 CGM
Sponsors:   Sansum Diabetes Research Institute;   Harvard John A. Paulson School of Engineering and Applied Sciences;   Mayo Clinic;   Icahn School of Medicine at Mount Sinai
Recruiting

Pharmacist and Data Driven Quality Improvement in Primary Care

Condition:   Medication Safety
Intervention:   Behavioral: P-DQIP
Sponsors:   University of Dundee;   NHS Tayside
Recruiting

Sensing Contact Lens-based Device for 24-hour Monitoring of Intraocular Pressure

Conditions:   Glaucoma, Open-Angle;   Healthy
Interventions:   Device: Goldfish;   Device: Tonometry
Sponsor:   Sensimed AG
Completed

Computer Scan Based Analysing System on Improving Stroke Management Quality Evaluation

Condition:   Acute Ischemic Stroke and Transient Ischemic Attacks
Intervention:   Behavioral: the response of KPI and corresponding suggestion
Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University
Recruiting

Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients

Conditions:   Hypertension Pulmonary Secondary Heart Failure;   Right Sided Heart Failure With Normal Ejection Fraction;   Heart Failure With Normal Ejection Fraction
Intervention:   Drug: Levosimendan 2.5 mg/ml Injectable Solution
Sponsor:   Tenax Therapeutics, Inc.
Recruiting

A Study of LY3322207 in Healthy Participants and in Participants With Hypertension (High Blood Pressure)

Condition:   Hypertension
Interventions:   Drug: LY3322207;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Recruiting

Study to Learn How the Drug Aflibercept Works in in Japanese Patients With Increased Eye Pressure That is Caused by New Blood Vessels Growing in the Eye (Neovascular Glaucoma or NVG). Safety of the Drug and Patients' Tolerability of the Drug Injection is Also Studied

Condition:   Glaucoma, Neovascular
Interventions:   Drug: Aflibercept (EYLEA, BAY86-5321);   Drug: Topical IOP-lowering drugs
Sponsors:   Bayer;   Regeneron Pharmaceuticals
Recruiting

Comparing Refractive and Visual Outcomes of MIGS and Traditional Surgeries

Conditions:   Glaucoma;   Ocular Hypertension
Intervention:  
Sponsors:   Wills Eye;   Allergan;   The American Society of Cataract and Refractive Surgery Foundation
Enrolling by invitation

Low Molecular Weight Heparin in Pregnancies With Unexplained Stillbirths

Condition:   Unexplained Stillbirth
Interventions:   Drug: Bemiparin;   Other: multivitamins and routine antenatal follow up
Sponsor:   Hawler Medical University
Completed

Effects of TIVA With Propofol Versus Inhalational Anaesthesia on Postoperative Pain After Hepatectomy

Condition:   Postoperative Pain
Interventions:   Drug: Propofol;   Drug: Sevoflurane
Sponsor:   The University of Hong Kong
Recruiting

Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus

Conditions:   Diabetes Mellitus, Type 1;   Pregnancy in Diabetes
Intervention:   Drug: Metformin
Sponsor:   Maisa Feghali
Not yet recruiting

Aerosol Therapy in Intensive Care Units

Conditions:   Respiration, Artificial;   Critical Care
Intervention:   Behavioral: aerosol therapy
Sponsor:   lvshan
Completed

Hemodynamic Evaluation of Levosimendan in Patients With PH-HFpEF

Conditions:   Hypertension Pulmonary Secondary;   Heart Failure, Right Sided;   Heart Failure With Normal Ejection Fraction
Interventions:   Drug: Levosimendan;   Drug: Matching Placebo
Sponsor:   Tenax Therapeutics, Inc.
Recruiting

A Study to Assess the Feasibility of an E-Health System (ZEMY) Designed to Manage Symptoms in Participants With Breast Cancer Under Anti-Cancer Treatment

Condition:   Breast Cancer
Interventions:   Device: ZEMY software;   Drug: Investigator's choice of anti-cancer treatment (except immunotherapy)
Sponsor:   Hoffmann-La Roche
Recruiting

Using Lay Health Advisors to Improve Hypertension Management

Condition:   Hypertension
Intervention:   Behavioral: Lay Health Advisor
Sponsor:   MetroHealth Medical Center
Enrolling by invitation

Umbrella Review of the DASH Dietary Pattern and Cardiometabolic Risk

Conditions:   Cardiovascular Risk Factor;   Cardiovascular Diseases;   Coronary Heart Disease;   Stroke;   Diabetes;   Blood Pressure;   Cholesterol; Lipidosis;   Inflammation;   Adiposity
Intervention:   Other: DASH dietary pattern
Sponsor:   University of Toronto
Active, not recruiting

An Integrated Assessment of the Safety and Effectiveness of Bexagliflozin for the Management of Essential Hypertension

Condition:   Essential Hypertension
Interventions:   Drug: Bexagliflozin;   Drug: Placebo
Sponsor:   Theracos
Completed

Surgical Idiopathic Intracranial Hypertension Treatment Trial

Condition:   Idiopathic Intracranial Hypertension
Interventions:   Drug: Acetazolamide;   Procedure: Optic Nerve Sheath Fenestration;   Procedure: Ventriculoperitoneal CSF Shunting
Sponsors:   Jaeb Center for Health Research;   National Eye Institute (NEI);   University of Iowa;   Icahn School of Medicine at Mount Sinai
Recruiting

Strategies To OPpose Sugars With Non-nutritive Sweeteners Or Water (STOP Sugars NOW) Trial

Conditions:   Healthy;   Overweight and Obesity;   Metabolic Syndrome;   PreDiabetes;   Diabetes;   Overweight;   Obesity;   Dysglycemia;   Cardiovascular Diseases;   Cardiovascular Risk Factor;   Hypertension
Interventions:   Other: Sugar-sweetened beverage (SSB);   Other: Non-nutritive sweetened beverages (NSB);   Other: Water
Sponsors:   University of Toronto;   Canadian Institutes of Health Research (CIHR)
Recruiting

Beijing Friendship Hospital Metabolic Surgery Database

Condition:   Metabolic Surgery
Intervention:  
Sponsor:   Beijing Friendship Hospital
Recruiting

DISCOVER Global Registry

Condition:   Type 2 Diabetes
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Pregnancy and Chronic Disease: The Effect of a Midwife-coordinated Maternity Care Intervention

Condition:   Chronic Diseases in Pregnancy
Intervention:   Behavioral: ChroPreg + standard care
Sponsor:   Rigshospitalet, Denmark
Recruiting

Establishment and Assessment of the HVPG Using Biofluid Mechanics (HVPGBFM)

Conditions:   Liver Cirrhosis;   Hypertension, Portal
Intervention:   Procedure: HVPG measurement
Sponsors:   Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University;   RenJi Hospital;   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Recruiting

PRIMEx - A Study of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH)

Condition:   PAH
Interventions:   Drug: 75mg CXA-10;   Drug: 150mg CXA-10;   Other: Placebo
Sponsors:   Complexa, Inc.;   Clinical Works;   Medpace, Inc.;   Philips Healthcare;   Cardiovascular Clinical Science Foundation;   MicroConstants
Recruiting

Study of Sparsentan in FSGS

Condition:   Focal Segmental Glomerulosclerosis
Interventions:   Drug: sparsentan;   Drug: irbesartan
Sponsor:   Retrophin, Inc.
Recruiting

Cooking for Health Optimization With Patients

Conditions:   Cardiovascular Diseases;   Cardiovascular Risk Factor;   Nutrition Disorders;   Diabetes;   Hypertension;   Cancer;   Depression;   Obesity;   Physical Activity
Intervention:   Behavioral: Treatment
Sponsor:   Tulane University
Recruiting

Phase 2 Study of TMX-049 in Subjects With Type 2 Diabetes and Albuminuria

Condition:   Diabetic Kidney Disease
Interventions:   Drug: TMX-049;   Drug: Placebo
Sponsor:   Teijin America, Inc.
Recruiting

Trial To Evaluate PF-06730512 In Adults With Primary Focal Segmental Glomerulosclerosis

Condition:   Focal Segmental Glomerulosclerosis (FSGS)
Intervention:   Drug: PF-06730512
Sponsor:   Pfizer
Recruiting

Peripheral Nerve Blocks for Above-the-knee Amputations

Conditions:   Peripheral Vascular Diseases;   Hyperglycaemia (Diabetic);   Hypertension;   Coronary Artery Disease;   Pulmonary Disease, Chronic Obstructive
Interventions:   Procedure: Peripheral nerve block;   Drug: Intravenous Sedatives;   Procedure: Lateral femoral cutaneous nerve blocks;   Procedure: Obturator nerve blocks
Sponsors:   University of Florida;   US Department of Veterans Affairs
Recruiting

Uric Acid Effects on Endothelium and Oxydative Stress

Conditions:   Oxidative Stress;   Endothelial Function;   Cardiovascular System;   Hypertension
Interventions:   Drug: Placebos;   Drug: Febuxostat;   Drug: Rasburicase
Sponsors:   Erasme University Hospital;   Fonds Erasme;   Fonds National de la Recherche Scientifique
Recruiting

Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD

Condition:   Coronary Artery Disease
Interventions:   Drug: High dose potent statin;   Drug: ACE-I (lisinopril) or ARB (losartan);   Drug: Aspirin;   Behavioral: Lifestyle Counseling;   Behavioral: Quality of Life Questionnaires
Sponsors:   University of Florida;   United States Department of Defense
Recruiting

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

Conditions:   Adrenal Gland Neoplasm;   Hypertension;   Bone Diseases, Metabolic;   Cardiovascular Disease;   Hyperinsulinemia
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Biodistribution of 89Zirconium-labelled GSK2398852 Using PET Imaging

Condition:   Amyloidosis
Interventions:   Drug: GSK2315698 (CPHPC);   Drug: GSK2398852 (unlabeled anti-SAP mAb);   Drug: 89Zr-GSK2398852 (89Zr-labeled anti-SAP mAb)
Sponsor:   GlaxoSmithKline
Terminated

IVM Versus IVF in High Antral Follicle Count Patients

Conditions:   PCOS;   IVF;   IVM
Interventions:   Procedure: IVM;   Procedure: IVF
Sponsor:   Mỹ Đức Hospital
Recruiting

Efficacy and Safety of Combination Ambrisentan and Tadalafil in Patients With Portopulmonary Hypertension

Conditions:   Portopulmonary Hypertension;   Pulmonary Hypertension;   Cirrhosis, Liver
Interventions:   Drug: Ambrisentan Pill;   Drug: Tadalafil Pill
Sponsors:   Ochsner Health System;   Gilead Sciences
Withdrawn

A Randomized Controlled Trial of Doxazosin for Nightmares, Sleep Disturbance, and Non-Nightmare Clinical Symptoms in PTSD

Condition:   Stress Disorders, Post-Traumatic
Interventions:   Drug: Doxazosin Mesylate, Extended Release;   Drug: Placebo
Sponsors:   San Francisco Veterans Affairs Medical Center;   United States Department of Defense;   Northern California Institute of Research and Education
Recruiting

Effect of Peripheral Laser Iridotomy Placement on Post-operative Visual Function

Condition:   Glaucoma, Angle-Closure
Interventions:   Procedure: Superior laser peripheral iridotomy;   Procedure: Temporal laser peripheral iridotomy
Sponsor:   University of the Incarnate Word
Recruiting

Effect of Reducing Sedentary Behavior on Blood Pressure

Conditions:   Hypertension;   Prehypertension
Intervention:   Behavioral: Intervention
Sponsors:   University of Pittsburgh;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Pulmonary Arterial Hypertension Improvement With Nutrition and Exercise (PHINE)

Conditions:   Pulmonary Arterial Hypertension;   Insulin Resistance
Intervention:   Behavioral: Nutrition and Exercise
Sponsors:   The Cleveland Clinic;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Evaluation of Visual and Task Performance

Conditions:   Glaucoma;   Macular Degeneration;   Glaucoma Suspect;   Optic Neuropathy;   Retinal Degeneration;   Visual Pathway Disorder
Intervention:   Diagnostic Test: Visual Performance tests
Sponsor:   Duke University
Enrolling by invitation

RNA Sequencing in the Framingham Heart Study Third Generation Cohort Exam 2

Conditions:   Cardiovascular Disease;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation

Novel Evaluation With QGC001 in Hypertensive Overweight Patients of Multiple Ethnic Origins

Condition:   Hypertension
Intervention:   Drug: QGC001
Sponsor:   Quantum Genomics SA
Completed

Comparison of the Medication Adherence of Patients Treated With Telmisartan/Hydrochlorothiazide or Telmisartan/Amlodipine Fixed Dose Combination (FDC) Versus Double-pill Combination Therapy in Real-world Japanese Therapeutic Practice

Condition:   Hypertension
Interventions:   Drug: subjects treated with telmisartan/hydrochlorothiazide;   Drug: Subjects treated with Telmisartan and amlodipine;   Drug: subjects treated with Telmisartan+hydrochlorothiazide double-pill combination group;   Drug: subjects treated with telmisartan+amlodipine double pill
Sponsor:   Boehringer Ingelheim
Not yet recruiting

CALM- 2 - Controlling and Lowering Blood Pressure With the MobiusHD™

Conditions:   Hypertension;   Resistant Hypertension
Interventions:   Device: MobiusHD;   Other: Sham Implantation
Sponsor:   Vascular Dynamics, Inc.
Recruiting

Atherosclerosis-Progression in Coronary Arteries Compared to Periphery Vessels

Condition:   Atherosclerosis
Intervention:  
Sponsor:   Medical University Innsbruck
Recruiting

Continuous Hyperosomolar Therapy for Traumatic Brain-injured Patients

Condition:   Moderate to Severe Traumatic Brain Injury
Intervention:   Drug: NaCl20% (Continuous hyperosmolar therapy)
Sponsor:   Nantes University Hospital
Recruiting

Right Heart Catheterization Using Magnetic Resonance Imaging Fluoroscopy and Passive Guidewires

Conditions:   Pulmonary Artery Hypertension;   Congenital Heart Disease;   Structural Heart Disease
Interventions:   Procedure: MRI Right Heart guidewire catheterization;   Device: Low SAR MRI;   Device: Exercise Ergometer
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Digital Ankle Brachial Index (ABI) as a Screening Tool in Detecting Peripheral Arterial Disease

Conditions:   Peripheral Artery Disease;   Amputation;   Smoking;   Diabetes;   Hypercholesterolemia;   Hypertension
Intervention:   Device: ABI using QuantaFlo™
Sponsor:   St. Louis University
Completed

Patient Characteristics and Treatment Modalities in COPD Patients in China

Condition:   Pulmonary Disease, Chronic Obstructive
Intervention:  
Sponsor:   GlaxoSmithKline
Recruiting

Spironolactone With Patiromer in the Treatment of Resistant Hypertension in Chronic Kidney Disease

Conditions:   Hyperkalemia;   Resistant Hypertension
Interventions:   Drug: Patiromer;   Drug: Placebo;   Drug: Spironolactone
Sponsor:   Relypsa, Inc.
Completed

Study of Oral Treprostinil in Subjects With Pulmonary Hypertension (PH) Associated With Heart Failure With Preserved Ejection Fraction (HFpEF)

Condition:   Pulmonary Hypertension Associated With HFpEF
Intervention:   Drug: Oral Treprostinil
Sponsor:   United Therapeutics
Recruiting

Investigating Idiopathic Pulmonary Fibrosis in Greece (INDULGE IPF)

Condition:   Idiopathic Pulmonary Fibrosis
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting

Oral Treprostinil in Subjects With Pulmonary Hypertension (PH) Associated With Heart Failure With Preserved Ejection Fraction (HFpEF)

Conditions:   Pulmonary Hypertension;   Heart Failure With a Preserved Ejection Fraction
Interventions:   Drug: Oral treprostinil;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting

To Evaluate Real-world Safety, Effectiveness and Appropriate Use of Micatrio® Combination Tablets Treatment in Patients With Hypertension

Condition:   Hypertension
Intervention:   Drug: T80/A5/H12.5 FDC
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Safety and Efficacy Study of A Viscoelastic-free Method for Implantable Collamer Lens (ICL) Implantation

Condition:   Myopia
Interventions:   Device: viscoelastic-free implantation system;   Device: standard viscoelastic-assisted Implantation system
Sponsor:   Wenzhou Medical University
Recruiting

EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)

Condition:   Heart Failure
Interventions:   Drug: Empagliflozin;   Drug: Placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting

EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)

Condition:   Heart Failure
Interventions:   Drug: Empagliflozin;   Drug: Placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting

Dimethyl Fumarate (DMF) in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension

Conditions:   Systemic Sclerosis;   Pulmonary; Hypertension
Interventions:   Drug: Dimethyl Fumarate (DMF);   Drug: Placebo Oral Tablet
Sponsors:   Robert Lafyatis;   Biogen
Recruiting

Cardiovascular Risk Screening and Risk Reduction in Women Vets

Conditions:   Cardiovascular Diseases;   Hypertension;   Hyperlipidemias;   Dyslipidemias;   Obesity;   Diabetes Mellitus;   Tobacco Use Disorder;   Overweight
Intervention:   Behavioral: CV Toolkit Components
Sponsor:   VA Office of Research and Development
Recruiting

Genomic Outcomes of Metformin

Conditions:   Coronary Artery Disease;   Mild Cognitive Impairment;   Obesity, Abdominal;   Hypertension
Interventions:   Drug: Metformin;   Drug: Placebo
Sponsors:   Wake Forest University Health Sciences;   National Institute on Aging (NIA)
Completed

Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Adempas (Riociguat, BAY63-2521);   Drug: Sildenafil;   Drug: Tadalafil
Sponsor:   Bayer
Recruiting

Trial to Evaluate Anticoagulation Therapy in Hemodialysis Patients With Atrial Fibrillation

Conditions:   Atrial Fibrillation;   End Stage Renal Disease
Interventions:   Drug: apixaban;   Drug: warfarin
Sponsors:   Christopher Granger, MD;   Bristol-Myers Squibb
Recruiting

Non-interventional, Postauthorization Safety Study of Ventavis for Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Ventavis (Iloprost, BAYQ6256)
Sponsor:   Bayer
Recruiting

Bleeding Frequency Under Anticoagulant Treatment in Pulmonary Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Oral anticoagulant treatment
Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
Recruiting

A Phase 3 Long-term Study of TAK-536 in Pediatric Patients 6 to Less Than 16 Years With Hypertension

Condition:   Pediatric Hypertension
Interventions:   Drug: TAK-536 2.5 mg;   Drug: TAK-536 5 mg
Sponsor:   Takeda
Active, not recruiting

Bosentan Treatment of Digital Ulcers Related to Systemic Sclerosis

Conditions:   Systematic Sclerosis;   Digital Ulcer;   Scleroderma
Intervention:   Drug: Bosentan group
Sponsor:   Elpen Pharmaceutical Co. Inc.
Recruiting

Vascular Aging in Flight Attendants With Occupational Secondhand Smoke Exposure

Conditions:   Vascular Aging;   Secondhand Smoking
Interventions:   Procedure: Spirometry;   Procedure: Pulse Wave Analysis;   Procedure: Peripheral arterial tonometry
Sponsors:   Cedars-Sinai Medical Center;   University of California, San Francisco
Suspended

Collection of Samples From Pregnant Women for the Evaluation of Preeclampsia (Pre-E) Biomarkers

Conditions:   Preeclampsia;   Hypertension;   Proteinuria;   Thrombocytopenia;   Renal Insufficiency;   Impaired Liver Function;   Pulmonary Edema
Intervention:  
Sponsor:   Progenity, Inc.
Recruiting

WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study)

Conditions:   Williams Syndrome;   Cardiovascular Disease;   Multisystem Developmental Disorder;   Elastin Gene Deletion;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Pregnancy Complications - A Probiotic Interventional Study

Conditions:   Preeclampsia;   Preterm Birth
Interventions:   Drug: probiotic;   Drug: placebo
Sponsor:   Sahlgrenska University Hospital, Sweden
Recruiting

A Study Investigating Routine Practice of Chronic Thromboembolic Pulmonary Hypertension Management in EMEA Countries

Condition:   Hypertension, Pulmonary
Intervention:   Other: Standard of care
Sponsor:   Bayer
Active, not recruiting

Primary Ovarian Insufficiency, Polycystic Ovary Syndrome & the CardiOvascular Risk Profile

Condition:   Cardiovascular Diseases
Intervention:   Procedure: cardiovascular screening
Sponsors:   UMC Utrecht;   VU University Medical Center;   Erasmus Medical Center
Completed

Cardiac Function and Exercise Capacity in Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Behavioral: Rehabilitation
Sponsors:   Centre Hospitalier Universitaire de Saint Etienne;   Ministry of Health, France
Recruiting

Comparing Efficacy and Safety of 2 Dose Regimens of Subcutaneous Administration of TEV-48125 Versus Placebo for the Preventive Treatment of Chronic Migraine

Condition:   Migraine
Interventions:   Drug: Fremanezumab;   Drug: Placebo
Sponsor:   Teva Branded Pharmaceutical Products, R&D Inc.
Completed

Beauty From Within Community Screening Project

Condition:   Heart Health Screening and Prevention
Interventions:   Procedure: Fingerstick cholesterol test;   Other: Atherosclerosis Cardiovascular Disease Risk assessment;   Procedure: Blood pressure measurement
Sponsor:   Cedars-Sinai Medical Center
Active, not recruiting

A Trial to Evaluate the Efficacy of PRM-151 in Subjects With Idiopathic Pulmonary Fibrosis (IPF)

Condition:   Idiopathic Pulmonary Fibrosis
Interventions:   Biological: PRM-151;   Other: placebo
Sponsor:   Promedior, Inc.
Active, not recruiting

Does Using a Low Vision Aid Device Improve Quality of Life in Glaucoma Patients?

Condition:   Glaucoma
Intervention:   Device: OrCam
Sponsor:   Wills Eye
Completed

Cardiac MRI in Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Device: Magnetic resonance Imaging
Sponsor:   University of California, San Francisco
Completed

Health Evaluation in African Americans Using RAS Therapy

Condition:   Alzheimer's Disease
Interventions:   Drug: Telmisartan 20mg;   Drug: Telmisartan 40mg;   Drug: Placebo
Sponsor:   Emory University
Recruiting

SPYRAL HTN-ON MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Recruiting

SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Recruiting

Obstructive Sleep Apnea in Obese Children and Teenagers - Occurrence and Importance of Intervention

Conditions:   Sleep Apnea, Obstructive;   Pediatric Obesity
Intervention:   Behavioral: Weight loss
Sponsors:   Zealand University Hospital;   Holbaek Sygehus
Completed

Prospective, Non-interventional, Multi-center, Post-authorization Safety Study of Riociguat for Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Recruiting

Lifestyle Interventions in Treatment-Resistant Hypertension

Condition:   Treatment-Resistant Hypertension
Interventions:   Behavioral: Structured center-based lifestyle intervention;   Behavioral: Standard education and physician advice
Sponsors:   Duke University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Fitbit / Healthy Weight Management Study

Conditions:   Obesity;   Bariatric Surgery
Intervention:   Behavioral: Fitbit
Sponsors:   Lancaster General Hospital;   Louise von Hess Medical Research Institute
Active, not recruiting

Chronic Hypertension and Pregnancy (CHAP) Project

Condition:   Hypertension
Interventions:   Drug: Anti-hypertensive therapy;   Other: No anti-hypertensive therapy (unless BP is severe)
Sponsors:   University of Alabama at Birmingham;   Columbia University;   Drexel University College of Medicine;   Rutgers, The State University of New Jersey;   Lehigh Valley Hospital;   Saint Peters University Hospital;   Christiana Care Health Services;   Washington University School of Medicine;   Duke University;   University of Texas Southwestern Medical Center;   The University of Texas Health Science Center, Houston;   Stanford University;   University of Pennsylvania;   The University of Texas Medical Branch, Galveston;   University of Utah;   Intermountain Health Care, Inc.;   University of California, San Francisco;   Johns Hopkins University;   University of Pittsburgh;   Ochsner Health System;   University of North Carolina, Chapel Hill;   National Heart, Lung, and Blood Institute (NHLBI);   WakeMed Health and Hospitals;   San Francisco General Hospital;   McKay-Dee Hospital;   Winthrop University Hospital;   New York Hospital Queens;   Latter Day Saints Hospital;   Lyndon B Johnson General Hospital;   Virtua Medical Group;   Bayview Medical Center;   Duke Regional Hospital;   Utah Valley Regional Medical Center;   Northwestern;   Brown (WIHRI);   Baylor College of Medicine;   Case Western/Metro Health;   Ohio State University;   University of Iowa;   University of California, San Diego;   Indiana University;   Unity Point Health-Meriter Hospital WI;   Weill Medical College of Cornell University;   University of Oklahoma;   Medical University of South Carolina;   Beaumont Hospital;   University of Colorado, Denver;   University of Kansas Medical Center;   Denver Health and Hospital Authority;   Gundersen Health System;   Aurora Health Care;   Oregon Health and Science University;   Medical College of Wisconsin;   Temple University;   New Jersey Medical School;   University of South Alabama;   Vanderbilt University;   University of Arkansas;   Miami Valley Hospital;   Emory University;   St. Luke's Hospital and Health Network, Pennsylvania;   Cleveland Clinic Fairview Hospital;   University of Tennessee Health Science Center;   TriHealth Inc.;   Cleveland Clinic Hillcrest Hospital
Recruiting

PC Protocol: Preconceptional Screening

Condition:   Infertility
Intervention:  
Sponsor:   UMC Utrecht
Recruiting

Long Term Safety and Efficacy of APD811 in Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: APD811
Sponsor:   Arena Pharmaceuticals
Active, not recruiting

Safety and Efficacy of APD811 in Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: APD811;   Drug: Placebo
Sponsor:   Arena Pharmaceuticals
Completed

Hypoxia and Inflammatory Injury in Human Renovascular Hypertension

Conditions:   Renal Artery Stenosis;   Ischemic Nephropathy;   Renovascular Disease;   Chronic Kidney Disease
Interventions:   Drug: Mesenchymal stem cell;   Procedure: Mesenchymal stem cell delivery with stent placement
Sponsors:   Mayo Clinic;   University of Mississippi Medical Center;   University of Alabama at Birmingham
Active, not recruiting

Retinal Thrombosis and Atherosclerosis

Condition:   Retinal Vein Occlusion
Intervention:  
Sponsors:   University of Roma La Sapienza;   University of Florence
Recruiting

Manchester Antenatal Vascular Service

Condition:   Vascular Disease
Intervention:   Other: no intervention
Sponsors:   Manchester University NHS Foundation Trust;   National Institute for Health Research, United Kingdom
Completed

Biomarker Guided Therapies in Stage A/B Heart Failure

Conditions:   Hypertension;   Diabetes;   Cardiovascular Disease
Interventions:   Drug: Carvedilol;   Drug: Spironolactone
Sponsors:   VA Office of Research and Development;   Baylor College of Medicine
Active, not recruiting

Diuretic Comparison Project

Condition:   Hypertension
Interventions:   Drug: Hydrochlorothiazide (HCTZ);   Drug: Chlorthalidone
Sponsor:   VA Office of Research and Development
Recruiting

Perioperative Blood Pressures and Chronic Hypertension

Condition:   Hypertension
Intervention:  
Sponsors:   Yale University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH )

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Recruiting

EXPERT, EXPosurE Registry RiociguaT in Patients With Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsor:   Bayer
Completed

Effects of Oral Sildenafil on Mortality in Adults With PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: sildenafil citrate
Sponsor:   Pfizer
Recruiting

Roxadustat in the Treatment of Anemia in Chronic Kidney Disease (CKD) Patients, Not on Dialysis, in Comparison to Darbepoetin Alfa

Condition:   Anemia in Chronic Kidney Disease in Non-dialysis Patients
Interventions:   Drug: Roxadustat;   Drug: darbepoetin alfa
Sponsors:   Astellas Pharma Europe B.V.;   FibroGen
Active, not recruiting

Improved Cardiovascular Risk Reduction to Enhance Rural Primary Care

Conditions:   Diabetes Mellitus;   Hypertension;   Coronary Artery Disease;   Atrial Fibrillation;   Stroke
Interventions:   Other: PHCVRS Intervention;   Other: Personal Health Record
Sponsor:   Korey Kennelty
Completed

Hydroxyurea in Pulmonary Arterial Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Drug: Hydroxyurea
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   The Cleveland Clinic
Withdrawn

Race And CPAP Effectiveness

Condition:   Sleep Apnea Syndromes
Intervention:   Device: Continuous positive airway pressure
Sponsor:   VA Office of Research and Development
Recruiting

Efficacy and Safety Study of Eravacycline Compared With Levofloxacin in Complicated Urinary Tract Infections

Condition:   cUTI
Interventions:   Drug: Eravacycline;   Drug: Levofloxacin
Sponsor:   Tetraphase Pharmaceuticals, Inc.
Completed

Evaluation of Sickle Cell Liver Disease

Condition:   Sickle Cell Disease
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Study to Assess the Safety, Tolerability and Pharmacokinetics (PK) of MK-8892 in Participants With Pulmonary Arterial Hypertension (PAH) (MK-8892-005)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: MK-8892;   Drug: Placebo for MK-8892
Sponsor:   Merck Sharp & Dohme Corp.
Completed

Correlation of Artherosclerotic Plaque Volume and Intima Media Thickness With Soluble P-selectin

Conditions:   Cardiovascular Risk Factors;   Coronary Artery Disease;   Cerebrovascular Disease;   Peripheral Artery Disease
Intervention:  
Sponsor:   Medical University Innsbruck
Active, not recruiting

A Study of Tadalafil in Pediatric Participants With Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Interventions:   Drug: Tadalafil;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Recruiting

NSAID Effects on Clinical and Imaging Breast Biomarkers

Conditions:   Inflammation;   Cancer;   Pain;   Hypertension
Intervention:   Drug: Sulindac
Sponsor:   Stony Brook University
Active, not recruiting

Natural History Study of Biomarkers in Pulmonary Arterial Hypertension

Conditions:   Pulmonary Disease;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Institutes of Health Clinical Center (CC)
Recruiting

A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn

Condition:   Pulmonary Hypertension, Familial Persistent, of the Newborn
Interventions:   Drug: placebo;   Drug: iv sildenafil
Sponsor:   Pfizer
Recruiting

Spironolactone for Pulmonary Arterial Hypertension

Conditions:   Pulmonary Arterial Hypertension;   Endothelial Dysfunction
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   National Institutes of Health Clinical Center (CC);   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   University of Pennsylvania;   University of Maryland;   Washington Hospital Center;   New England Medical Center, Tufts University School of Medicine
Recruiting

Adjunctive Renal Denervation in the Treatment of Atrial Fibrillation

Conditions:   Uncontrolled Hypertension;   Atrial Fibrillation
Intervention:   Device: Boston Scientific Vessix Renal Denervation System
Sponsor:   Vivek Reddy
Active, not recruiting

PAHTCH Pulmonary Arterial Hypertension Treatment With Carvedilol for Heart Failure (Carvedilol)

Condition:   Pulmonary Hypertension
Interventions:   Drug: Carvedilol;   Drug: placebo
Sponsors:   The Cleveland Clinic;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Completed

An Open-Label, Long-Term Study of Oral Treprostinil in Subjects With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: UT-15C (treprostinil diethanolamine)
Sponsor:   United Therapeutics
Recruiting

Blood Vessel Study

Condition:   Endothelial Cell Function
Intervention:  
Sponsor:   National Institute of Environmental Health Sciences (NIEHS)
Completed

Post-Authorisation Safety Cohort Observation of RetacritTM (Epoetin Zeta) Administered Subcutaneously for the Treatment of Renal Anaemia

Conditions:   Renal Anemia;   Pregnancy;   Lactation
Intervention:  
Sponsors:   Pfizer;   Hospira, now a wholly owned subsidiary of Pfizer
Active, not recruiting

Inflammation, Viral Replication, and Atherosclerosis in Treated HIV Infection

Condition:   Atherosclerosis
Intervention:  
Sponsors:   University of California, San Francisco;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Nebivolol and the Endothelin (ET)-1 System

Conditions:   Prehypertension;   Hypertension
Interventions:   Drug: Nebivolol;   Drug: Metoprolol;   Drug: Placebo;   Other: Forearm Blood Flow (FBF) response to BQ-123 (100 mol/min);   Other: FBF response to BQ-123 (100 nmol/min)+BQ-788(50 nmol/min);   Other: FBF response to Acetylcholine;   Other: FBF response to Sodium Nitroprusside;   Other: FBF response to BQ-123+BQ-788+ACh
Sponsors:   University of Colorado, Boulder;   Forest Laboratories
Completed

A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV)

Conditions:   Congenital Cytomegalovirus Infection;   Maternal Cytomegalovirus Infection
Interventions:   Drug: CMV hyperimmune globulin;   Other: Placebo
Sponsors:   The George Washington University Biostatistics Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting

Marinobufagenin as a Target for DIGIBIND in Preeclampsia

Condition:   Preeclampsia
Intervention:  
Sponsor:   National Institute on Aging (NIA)
Completed

Spaeth/Richman Contrast Sensitivity Test

Condition:   Glaucoma
Interventions:   Diagnostic Test: Spaeth/Richman Contrast Sensitivity Test;   Diagnostic Test: Pelli-Robson Contrast Sensitivity Chart
Sponsors:   Wills Eye;   Pfizer
Completed

Controlling Hypertension in Diabetes- Feasibility Study

Conditions:   Type 2 Diabetes;   Hypertension;   Hyperlipidemia
Intervention:   Behavioral: home health/primary care collaboration
Sponsors:   Albert Einstein College of Medicine, Inc.;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunction

Conditions:   Hypertension, Pulmonary;   Ventricular Dysfunction, Left
Interventions:   Drug: Riociguat (Adempas, BAY63-2521);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Idiopathic Intracranial Hypertension Treatment Trial

Condition:   Idiopathic Intracranial Hypertension
Interventions:   Drug: Acetazolamide;   Drug: Placebo;   Behavioral: Formal weight loss counselling program
Sponsors:   St. Luke's-Roosevelt Hospital Center;   National Eye Institute (NEI);   University of Rochester;   University of Iowa;   University of California, Davis
Completed

BAY63-2521 - Long-term Extension Study in Patients With Chronic Thromboembolic Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsor:   Bayer
Active, not recruiting

European Increlex® (Mecasermin [rDNA Origin] Injection) Growth Forum Database - IGFD Registry

Condition:   IGF1 Deficiency
Intervention:   Drug: Increlex®
Sponsor:   Ipsen
Recruiting

Epidemiology and Pathogenesis of HIV-Associated Pulmonary Hypertension

Conditions:   HIV Infection;   Pulmonary Hypertension;   Endothelial Function;   HIV Infections
Intervention:  
Sponsors:   University of California, San Francisco;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Genetics of Type 2 Diabetes in West Africans

Conditions:   Hypertension;   Diabetes
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

Impact of Multiple Doses of BAY63-2521 on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Patients With Interstitial Lung Disease (ILD) Associated Pulmonary Hypertension (PH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsor:   Bayer
Active, not recruiting

Study Of Letrozole With Or Without Palbociclib (PD-0332991) For The First-Line Treatment Of Hormone-Receptor Positive Advanced Breast Cancer

Condition:   Breast Cancer
Interventions:   Drug: PD 0332991;   Drug: letrozole
Sponsor:   Pfizer
Completed

Aerobic Exercise in Patients With Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease
Interventions:   Other: Aerobic exercise;   Other: Patient Education (Placebo);   Other: Accelerometry-based activity
Sponsors:   National Institutes of Health Clinical Center (CC);   George Mason University;   Inova Fairfax Hospital
Completed

Effects of Propranolol on Responses to Drug-Related Imagery Scripts

Condition:   Cocaine Dependence
Interventions:   Drug: Propranolol;   Drug: Placebo
Sponsor:   National Institute on Drug Abuse (NIDA)
Terminated

Role of Nitric Oxide in Malaria

Conditions:   Malaria;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Pulmonary Hypertension, Hypoxia and Sickle Cell Disease

Conditions:   Chuvash Polycythemia;   Cerebrovascular Disease;   Pulmonary Hypertension;   Sickle Cell Anemia
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Abdominal Obesity and Cardiovascular Risk Factors in Women Who Survived Cancer or a Related Illness Following Total Body Irradiation and Stem Cell Transplant

Conditions:   Leukemia;   Hodgkin's Lymphoma;   Non-Hodgkin's Lymphoma;   Myelodysplastic Syndrome
Intervention:   Other: Questionnaires, Laboratory tests, Abdominal MRI
Sponsors:   Memorial Sloan Kettering Cancer Center;   Queen's University, Kingston, Ontario;   Weill Medical College of Cornell University
Active, not recruiting

Pulmonary Hypertension in Patients With Sickle Cell Disease in Nigeria

Conditions:   Secondary Pulmonary Arterial Hypertension;   Sickle Cell Disease;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Interventions:   Drug: Nitric Oxide/INP Pulse Delivery;   Drug: Nitric Oxide/INO Pulse Delivery
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Establishment of a Perinatal Database and a Bank of Biological Materials

Conditions:   Preterm Labor;   Preterm Birth;   Pregnancy
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed

Sildenafil to Treat HIV-Associated Pulmonary Hypertension

Condition:   HIV
Interventions:   Procedure: MRI;   Drug: L-NMMA;   Drug: Acetylcholine
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Terminated

Biological Markers of Disease in the Prediction of Preterm Delivery, Preeclampsia and Intra-Uterine Growth Retardation: A Longtitudinal Study

Conditions:   Prenatal Care;   Premature Birth
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed

Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia

Conditions:   Sickle Cell Disease;   Chronic Kidney Disease;   Pulmonary Hypertension
Intervention:   Drug: Erythropoietin and Hydroxyurea
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Clinical and Molecular Studies in Families With Glaucoma and Related Diseases

Condition:   Glaucoma
Intervention:  
Sponsor:   National Eye Institute (NEI)
Completed

Olmesartan Alone or in Combination With Hydrochlorothiazide in Subjects With Mild to Moderate Essential Hypertension

Condition:   Essential Hypertension
Intervention:   Drug: olmesartan alone or in combination with hydrochlorothiazide
Sponsor:   Pfizer
Completed

Endothelial Cell Dysfunction in Pulmonary Hypertension

Condition:   Secondary Pulmonary Arterial Hypertension
Interventions:   Procedure: Heart Catheterization;   Drug: Nitric Oxide;   Drug: Nitric Oxide/INO Pulse Delivery;   Drug: Sodium Nitrite
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed

Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension

Conditions:   Sickle Cell Anemia;   Pulmonary Hypertension
Interventions:   Drug: Nitric Oxide;   Device: INO Pulse - NO Delivery System
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   Mallinckrodt
Completed

Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia

Conditions:   Pulmonary Hypertension;   Sickle Cell Anemia;   Sickle Cell Disease
Intervention:  
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Evaluation of Patients With Liver Disease

Conditions:   Biliary Liver Cirrhosis;   Hemochromatosis;   Hepatitis;   Hepatolenticular Degeneration;   Liver Disease
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Diabetes and Heart Disease Risk in Blacks

Conditions:   Cardiovascular;   Diabetes;   Obesity;   Hypertension
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Evaluation of Patients With Heart Disease Not Eligible for Research Protocols

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting