High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Reducing Disparities in the Treatment of Hypertension Using the OWL mHealth Tool

Condition:   Hypertension
Intervention:   Behavioral: OWL-Hypertension 8 Wk Trial
Sponsors:   Paula Gardiner;   National Center for Advancing Translational Science (NCATS);   National Heart, Lung, and Blood Institute (NHLBI);   National Institutes of Health (NIH);   Center for Advancing Point of Care Technologies
Recruiting

Prenatal Mindfulness & Hypertension Study

Condition:   Hypertension in Pregnancy
Intervention:   Behavioral: Mindfulness Training
Sponsor:   Lifespan
Recruiting

Conquering Hypertension in Vietnam: Solutions at Grassroots Level

Condition:   Hypertension
Interventions:   Other: Vietnam National Hypertension Program;   Other: Expanded community health worker services;   Behavioral: Storytelling intervention;   Behavioral: Home blood pressure self-monitoring
Sponsors:   Ministry of Health, Vietnam;   University of Massachusetts, Worcester;   Baylor Research Institute;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

Magnesium Sulphate Versus Lidocaine for Control of Emergence Hypertension

Conditions:   Craniotomy;   Hypertension
Interventions:   Drug: Magnesium sulphate;   Drug: Lidocaine Hydrochloride;   Drug: Normal saline
Sponsor:   Ahmed Mohamed ELbadawy
Recruiting

Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Interventions:   Drug: Nitric Oxide/INP Pulse Delivery;   Drug: Nitric Oxide/INO Pulse Delivery
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Young Adult Hypertension Self-Management Clinical Trial

Conditions:   Hypertension;   Blood Pressure;   Lifestyle Risk Reduction
Interventions:   Behavioral: Home Blood Pressure Monitoring;   Behavioral: Telephone Health Coaching
Sponsors:   University of Wisconsin, Madison;   National Heart, Lung, and Blood Institute (NHLBI);   Aurora Health Care
Recruiting

Effect of Normobaric Hypoxia and Hyperoxia in Patients With Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Other: Hypoxia and Hyperoxia
Sponsor:   University of Zurich
Recruiting

Clinical Study of Adipose Derived Mesenchymal Stem Cells for Treatment of Pulmonary Arterial Hypertension

Condition:   Pulmonary Hypertension
Interventions:   Biological: adipose derived mesenchymal stem cells;   Drug: Conventional drug therapy(expectorant,bronchodilator)
Sponsor:   Liaocheng People's Hospital
Recruiting

Effects of Treprostinil on Right Ventricular Structure and Function in Patients With Pulmonary Arterial Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Drug: Treprostinil
Sponsor:   Magdi H. Yacoub
Recruiting

Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension

Conditions:   Sickle Cell Anemia;   Pulmonary Hypertension
Interventions:   Drug: Nitric Oxide;   Device: INO Pulse - NO Delivery System
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   Mallinckrodt
Completed

Understanding the Exercise-Hypertension Paradox

Condition:   Hypertension
Interventions:   Dietary Supplement: Oral Antioxidant;   Other: Exercise rehabilitation
Sponsor:   VA Office of Research and Development
Recruiting

Cerebral Tissue Oxygenation in Highlanders/Lowlanders

Condition:   High Altitude Pulmonary Hypertension
Intervention:  
Sponsors:   University of Zurich;   National Center of Cardiology and Internal Medicine, Kyrgyzstan
Completed

Riociguat in Children With Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsors:   Bayer;   Merck Sharp & Dohme Corp.
Recruiting

Portal Hypertension and Systemic Endothelial Function

Conditions:   Cystic Fibrosis;   Portal Hypertension
Interventions:   Other: measure of endothelial function;   Biological: Blood sample;   Other: Hepatic elastography;   Diagnostic Test: Injected abdominal CT
Sponsor:   Hopital Foch
Recruiting

Right Ventricular Function During Exercise in Highlanders/Lowlanders

Condition:   High Altitude Pulmonary Hypertension
Intervention:  
Sponsors:   University of Zurich;   National Center of Cardiology and Internal Medicine, Kyrgyzstan
Completed

Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer

Conditions:   Breast Carcinoma;   Hypertension
Intervention:   Other: Laboratory Biomarker Analysis
Sponsor:   National Cancer Institute (NCI)
Recruiting

Clinical Efficacy of Telmisartan in Reducing Cardiac Remodeling Among Obese Patients With Hypertension

Condition:   Hypertension
Interventions:   Drug: telmisartan;   Drug: amlodipine
Sponsor:   First Affiliated Hospital Xi'an Jiaotong University
Recruiting

Right Ventricular Function at Rest in Highlanders/Lowlanders

Condition:   High Altitude Pulmonary Hypertension
Intervention:  
Sponsors:   University of Zurich;   National Center of Cardiology and Internal Medicine, Kyrgyzstan
Completed

Effect of Exercise Training in Patients With Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Interventions:   Behavioral: respiratory and exercise therapy;   Behavioral: respiratory and exercise therapy with supplemental oxygen
Sponsor:   University of Zurich
Recruiting

The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Paradise Renal Denervation System;   Procedure: Renal Angiogram
Sponsor:   ReCor Medical, Inc.
Recruiting

Pulmonary Hypertension Institutional Registry

Condition:   Death
Intervention:  
Sponsor:   Hospital Italiano de Buenos Aires
Withdrawn

EXPEDITE: A Study of Remodulin Induction Followed by Orenitram Optimization to Treat Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Intravenous/Subcutaneous Treprostinil; Oral Treprostinil
Sponsor:   United Therapeutics
Recruiting

Prospective, Non-interventional, Multi-center, Post-authorization Safety Study of Riociguat for Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Recruiting

Sildenafil to Treat HIV-Associated Pulmonary Hypertension

Condition:   HIV
Interventions:   Procedure: MRI;   Drug: L-NMMA;   Drug: Acetylcholine
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Terminated

Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH )

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Recruiting

Quantitative Dual Energy Computed Tomography in Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Other: dual energy CT scans
Sponsor:   University Hospital, Bordeaux
Recruiting

Hydroxyurea in Pulmonary Arterial Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Drug: Hydroxyurea
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   The Cleveland Clinic
Withdrawn

Catheter Ablation of Atrial Fibrillation in Patients With Pulmonary Hypertension Hypertension: a Randomised Study

Conditions:   Atrial Fibrillation;   Pulmonary Hypertension
Intervention:   Procedure: Catheter ablation
Sponsor:   General University Hospital, Prague
Recruiting

Impact of Self-monitoring of Blood Pressure and Self-titration of Medication in the Control of Hypertension (ADAMPA)

Conditions:   Hypertension;   Adjustment;   Adherence, Medication
Intervention:   Other: Self-monitoring/Self-titration
Sponsors:   Fundación para la Investigación del Hospital Clínico de Valencia;   Spanish Clinical Research Network - CAIBER;   Carlos III Health Institute
Active, not recruiting

Cardiovascular Effects of Angiotensin (1-7) in Essential Hypertension

Conditions:   Hypertension;   Hypertension, Essential
Interventions:   Drug: Angiotensin (1-7);   Drug: Trimethaphan;   Drug: Phenylephrine
Sponsor:   Vanderbilt University
Recruiting

Management of Uncontrolled Hypertension (HTN)

Condition:   Hypertension
Interventions:   Device: Ambulatory blood pressure monitor (ABPM);   Other: Chronotherapy
Sponsor:   University of Florida
Recruiting

Effect of Selexipag on Daily Life Physical Activity of Patients With Pulmonary Arterial Hypertension.

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Selexipag;   Drug: Placebo
Sponsor:   Actelion
Active, not recruiting

A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunction

Conditions:   Hypertension, Pulmonary;   Ventricular Dysfunction, Left
Interventions:   Drug: Riociguat (Adempas, BAY63-2521);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Angiotensin 1-7 in Obesity Hypertension

Conditions:   Obesity;   Hypertension
Interventions:   Drug: Angiotensin-(1-7);   Drug: Saline
Sponsors:   Amy Arnold;   American Heart Association
Recruiting

Hydroxyurea for Children and Young Adults With Sickle Cell Disease and Pulmonary Hypertension

Conditions:   Sickle Cell Disease;   Pulmonary Hypertension
Intervention:   Drug: Hydroxyurea
Sponsor:   Ann & Robert H Lurie Children's Hospital of Chicago
Terminated

Clinical Study of Inhaled GB002 for Treatment of WHO Group I Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: GB002;   Drug: Placebo;   Device: Generic Dry Powder Inhaler
Sponsor:   GB002, Inc., a wholly owned subsidiary of Gossamer Bio, Inc.
Recruiting

AI Activity Study in Patients With Elevated Blood Pressure

Condition:   Hypertension
Interventions:   Behavioral: Artificial Intelligence (AI) Activity;   Behavioral: 10,000 steps
Sponsor:   University of California, San Francisco
Not yet recruiting

A Study to Evaluate ALN-AGT01 in Patients With Hypertension

Condition:   Hypertension
Interventions:   Drug: ALN-AGT01;   Drug: ALN-AGT01-Matching Placebo;   Drug: Irbesartan;   Drug: Irbesartan-Matching Placebo
Sponsor:   Alnylam Pharmaceuticals
Recruiting

Acute Hemodynamic Effect of Acetazolamide in Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Interventions:   Drug: Acetazolamide;   Drug: Placebo
Sponsor:   University of Zurich
Completed

Taekwondo Training and Postmenopausal Women With Stage-2 Hypertension

Conditions:   Menopause;   Hypertension
Intervention:   Behavioral: Taekwondo training
Sponsor:   University of Nebraska, Omaha
Completed

Surgical Idiopathic Intracranial Hypertension Treatment Trial

Condition:   Idiopathic Intracranial Hypertension
Interventions:   Drug: Acetazolamide;   Procedure: Optic Nerve Sheath Fenestration;   Procedure: Ventriculoperitoneal CSF Shunting
Sponsors:   Jaeb Center for Health Research;   National Eye Institute (NEI);   University of Iowa;   Icahn School of Medicine at Mount Sinai
Recruiting

Effect of Inhaled Albuterol in Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Interventions:   Drug: albuterol first then placebo;   Drug: placebo first then albuterol
Sponsor:   University of Miami
Recruiting

Endothelial Cell Dysfunction in Pulmonary Hypertension

Condition:   Secondary Pulmonary Arterial Hypertension
Interventions:   Procedure: Heart Catheterization;   Drug: Nitric Oxide;   Drug: Nitric Oxide/INO Pulse Delivery;   Drug: Sodium Nitrite
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed

Slow and Deep Breathing to Lower Blood Pressure in Women With Pregnancy-induced Hypertension

Condition:   Pregnancy-Induced Hypertension
Intervention:   Other: Slow and deep breathing
Sponsor:   Bournemouth University
Not yet recruiting

Zürich Pulmonary Hypertension Outcome Assessment Cohort

Condition:   Pulmonary Hypertension Outcome Assessment
Intervention:   Other: PH target therapy according to physician
Sponsor:   University of Zurich
Recruiting

An Open-Label, Long-Term Study of Oral Treprostinil in Subjects With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: UT-15C (treprostinil diethanolamine)
Sponsor:   United Therapeutics
Recruiting

miRNA and Myokines in Patients With PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Other: Exercise Rehab
Sponsor:   University of Pittsburgh
Recruiting

Emricasan, an Oral Caspase Inhibitor, in Subjects With Non-Alcoholic Steatohepatitis (NASH) Cirrhosis and Severe Portal Hypertension

Conditions:   Cirrhosis;   Portal Hypertension;   Non-alcoholic Steatohepatitis
Interventions:   Drug: Emricasan;   Drug: Placebo
Sponsor:   Conatus Pharmaceuticals Inc.
Completed

Observatory of Pulmonary Arterial Hypertension of Congenital Heart Disease

Condition:   Pulmonary Arterial Hypertension of Congenital Heart Disease
Intervention:  
Sponsor:   French Cardiology Society
Active, not recruiting

Observatory: Search for Prognostic Factors of Pulmonary Hypertension Post-capillary in Heart Failure

Conditions:   Heart Failure;   Post-capillary Pulmonary Hypertension
Intervention:  
Sponsors:   French Cardiology Society;   CHRU Lille, Dr Nicolas LAMBLIN
Active, not recruiting

The Effects of Swimming on Elderly Women With Stage-2 Hypertension

Conditions:   Menopause;   Hypertension
Intervention:   Behavioral: Swimming
Sponsor:   University of Nebraska, Omaha
Completed

A Study Investigating Routine Practice of Chronic Thromboembolic Pulmonary Hypertension Management in EMEA Countries

Condition:   Hypertension, Pulmonary
Intervention:   Other: Standard of care
Sponsor:   Bayer
Active, not recruiting

Safety, Pharmacokinetics and Efficacy Study of QCC374 in PAH Patients

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: QCC374;   Drug: Placebo Matching
Sponsor:   Novartis Pharmaceuticals
Terminated

Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)

Condition:   Systemic Sclerosis-Associated PAH
Interventions:   Biological: Rituximab;   Other: Placebo;   Diagnostic Test: CMRI;   Drug: prednisone;   Drug: methylprednisolone;   Drug: diphenhydramine;   Drug: acetaminophen
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Autoimmunity Centers of Excellence
Active, not recruiting

BAY63-2521:Long-term Extension Study in Patients With Pulmonary Arterial Hypertension

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (BAY63-2521)
Sponsor:   Bayer
Active, not recruiting

Renal Sympathetic Denervation From The Adventitia on Hypertension

Condition:   Primary Aldosteronism Due to Aldosterone Producing Adenoma
Intervention:   Device: Renal Sympathetic Denervation
Sponsor:   Henan Institute of Cardiovascular Epidemiology
Recruiting

Study of Rhopressa® for the Reduction of Elevated Intraocular Pressure in Patients With Glaucoma or Ocular Hypertension in a Real-world Setting

Conditions:   Glaucoma, Open-Angle;   Ocular Hypertension
Intervention:   Drug: Netarsudil Ophthalmic Solution 0.02%
Sponsor:   Aerie Pharmaceuticals
Active, not recruiting

Association Between a Multi-Gene Panel and Renal Denervation Effectiveness in Patients With Hypertension

Condition:   Hypertension
Intervention:   Genetic: Geneticure for RDN Genetic Panel
Sponsor:   Geneticure, LLC
Not yet recruiting

HIRREM for Stage 1 Primary Hypertension

Conditions:   Hypertension;   Blood Pressure;   Cardiovascular Diseases;   Cardiovascular Risk Factor;   Autonomic Nervous System Imbalance
Interventions:   Device: HIRREM;   Other: Continued Current Care
Sponsor:   Wake Forest University Health Sciences
Recruiting

A Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension

Conditions:   Glaucoma;   Open-Angle Ocular Hypertension
Interventions:   Drug: Bimatoprost SR;   Drug: Sham Bimatoprost SR;   Procedure: Selective Laser Trabeculoplasty;   Procedure: Sham Selective Laser Trabeculoplasty
Sponsor:   Allergan
Recruiting

Pulmonary Hypertension, Hypoxia and Sickle Cell Disease

Conditions:   Chuvash Polycythemia;   Cerebrovascular Disease;   Pulmonary Hypertension;   Sickle Cell Anemia
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Gene Polymorphisms of Corticosteroid-induced Ocular Hypertension

Condition:   Corticosteroid Induced Ocular Hypertension/Glaucoma
Intervention:   Other: SNP analysis
Sponsor:   Maastricht University Medical Center
Recruiting

Retrospective Data Analysis of Data From the Zurich PH Registry

Conditions:   Pulmonary Hypertension;   Chronic Thromboembolic Pulmonary Hypertension;   Pulmonary Artery Hypertension
Intervention:  
Sponsor:   University of Zurich
Completed

The Exercise, Arterial Modulation and Nutrition in Youth South Africa Study

Conditions:   Hypertension;   Retinal Artery Stenosis;   Childhood Obesity
Intervention:  
Sponsors:   North-West University, South Africa;   National Research Foundation of South Africa;   Medical Research Council, South Africa
Active, not recruiting

Renal Stent Placement for the Treatment of Renal Artery Stenosis in Patients With Resistant Hypertension

Conditions:   Renal Artery Stenosis;   Hypertension, Renovascular
Intervention:   Device: iCAST™ Rx Stent System
Sponsor:   Atrium Medical Corporation
Active, not recruiting

A Long-term Extension Study of Riociguat in Patients With Symptomatic Pulmonary Arterial Hypertension.

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Adempas (Riociguat, BAY63-2521)
Sponsor:   Bayer
Recruiting

Pulmonary Hypertension in Patients With Sickle Cell Disease in Nigeria

Conditions:   Secondary Pulmonary Arterial Hypertension;   Sickle Cell Disease;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID)-2.0

Condition:   Hypertension
Intervention:  
Sponsors:   National Human Genome Research Institute (NHGRI);   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Safety and Efficacy of Ophthalmic Phentolamine Mesylate in Glaucoma

Conditions:   Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Phentolamine Mesylate Ophthalmic Solution 1%;   Other: Phentolamine Mesylate Ophthalmic Solution Vehicle (Placebo)
Sponsor:   Ocuphire Pharma, Inc.
Recruiting

Adrenal Suppression and Absorption Study of Halobetasol Propionate Foam in Subjects 12-17 With Plaque Psoriasis

Condition:   Plaque Psoriasis
Intervention:   Drug: Halobetasol Topical Foam
Sponsor:   Mayne Pharma International Pty Ltd
Recruiting

Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.

Conditions:   High Altitude Pulmonary Hypertension;   Sleep Apnea
Intervention:  
Sponsors:   University of Zurich;   National Center of Cardiology and Internal Medicine, Kyrgyzstan
Completed

The Effect of Baroreflex Activation Therapy (BAT) on Blood Pressure and Sympathetic Function in Patients With Resistant Hypertension (The Nordic BAT Study)

Condition:   Resistant Hypertension
Interventions:   Device: BAT;   Other: Placebo
Sponsors:   Helsinki University Central Hospital;   Skane University Hospital;   Sahlgrenska University Hospital, Sweden;   Karolinska Institutet;   Odense University Hospital;   University of Oslo;   Helsinki University
Recruiting

Hypertension With Unsatisfactory Sleep Health

Conditions:   Insomnia;   Hypertension
Interventions:   Behavioral: Brief Behavioral Treatment for Insomnia;   Behavioral: Sleep Healthy Using the Internet;   Behavioral: Enhanced Usual Care
Sponsors:   University of Pittsburgh;   University of Virginia;   Carolinas Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Adempas (Riociguat, BAY63-2521);   Drug: Sildenafil;   Drug: Tadalafil
Sponsor:   Bayer
Recruiting

BPS-314d-MR-PAH-303 (BEAT OLE)

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Beraprost Sodium 314d Modified Release tablets
Sponsor:   Lung Biotechnology PBC
Active, not recruiting

Acute Exposure to Simulated Hypoxia on Exercise Capacity

Condition:   Pulmonary Hypertension
Interventions:   Device: Simulated Altitude (FiO2: 15.1%);   Device: Shamed Hypoxia (FiO2: 20.9)
Sponsor:   University of Zurich
Completed

Acute Exposure of Simulated Hypoxia on Pulmonary Artery Pressure and Right Heart Function (Echo)

Condition:   Pulmonary Hypertension
Interventions:   Device: Simulated Altitude (FiO2: 15.1%);   Device: Shamed Hypoxia (FiO2: 20.9)
Sponsor:   University of Zurich
Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MK8266 in Hypertensive Men (MK-8266-002)

Condition:   Hypertension
Interventions:   Drug: MK-8226 BID, 1 mg;   Drug: MK-8266 BID, 1.8 mg;   Drug: MK-8266 TID, 1.8 mg;   Drug: MK-8266 TID, 2.4 mg;   Drug: Placebo BID (Panel A);   Drug: Placebo BID (Panel B);   Drug: Placebo TID (Panel C);   Drug: Placebo TID (Panel D);   Drug: Placebo TID (Panel E)
Sponsor:   Merck Sharp & Dohme Corp.
Completed

Effect of Renal Denervation on Atrial Fibrillation

Conditions:   Arterial Hypertension;   Atrial Fibrillation
Interventions:   Procedure: Sympathetic Renal Denervation;   Device: Implantable Loop Recorder
Sponsor:   Hippocration General Hospital
Not yet recruiting

Hemodynamic Effects of BPA at Rest and During Exercise in CTEPH

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Intervention:   Diagnostic Test: Invasive exercise testing
Sponsors:   Aarhus University Hospital;   Nagoya University;   Department of Pulmonary Circulation and Thromboembolic Diseases, Medical Center for Postgraduate Med
Not yet recruiting

CXA-10 Study in Subjects With Pulmonary Arterial Hypertension

Condition:   PAH
Intervention:   Drug: CXA-10
Sponsors:   Complexa, Inc.;   Medpace, Inc.;   Innovative Analytics;   Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Recruiting

PRIMEx - A Study of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH)

Condition:   PAH
Interventions:   Drug: 75mg CXA-10;   Drug: 150mg CXA-10;   Other: Placebo
Sponsors:   Complexa, Inc.;   Medpace, Inc.;   Philips Healthcare;   Cardiovascular Clinical Science Foundation;   MicroConstants;   Innovative Analytics;   Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Recruiting

Effects of Oral Sildenafil on Mortality in Adults With PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: sildenafil citrate
Sponsor:   Pfizer
Recruiting

Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypertension

Conditions:   Scleroderma, Diffuse;   Scleroderma, Systemic;   Scleroderma, Limited;   Sclerosis, Progressive Systemic;   Skin Diseases;   Connective Tissue Diseases;   Pathologic Processes;   Autoimmune Diseases
Interventions:   Drug: Oral Ifetroban;   Drug: Oral Placebo
Sponsor:   Cumberland Pharmaceuticals
Recruiting

Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH

Condition:   Pulmonary Artery Hypertension
Intervention:  
Sponsor:   Laval University
Recruiting

Efficacy, Safety, and Tolerability Study of Pirfenidone in Combination With Sildenafil in Participants With Advanced Idiopathic Pulmonary Fibrosis (IPF) and Risk of Group 3 Pulmonary Hypertension

Condition:   Idiopathic Pulmonary Fibrosis
Interventions:   Drug: Pirfenidone;   Drug: Placebo;   Drug: Sildenafil
Sponsor:   Hoffmann-La Roche
Active, not recruiting

Long-term Oxygen Therapy in Patients With Chronic Obstructive Pulmonary Disease Who Live at High Altitude

Condition:   COPD
Intervention:   Drug: Oxygen
Sponsors:   Fundación Neumologica Colombiana;   Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnología (COLCIENCIAS)
Recruiting

Chronic Clinical Effect of Acetazolamide

Condition:   Hypertension, Pulmonary
Interventions:   Drug: Acetazolamide;   Drug: Placebo
Sponsor:   University of Zurich
Recruiting

Remote BP Monitoring in the PP Period

Condition:   Hypertensive Disorder of Pregnancy
Intervention:   Device: Remote Patient Monitoring
Sponsors:   Columbia University;   Philips Healthcare;   New York Presbyterian Hospital
Active, not recruiting

Long-term Outcomes of Pregnant Women With PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Other: Observational study
Sponsor:   RenJi Hospital
Recruiting

Role of Nitric Oxide in Malaria

Conditions:   Malaria;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Open-label, Clinical Study to Evaluate the Safety and Tolerability of TreT in Subjects With PAH Currently Using Tyvaso

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Treprostinil Inhalation Powder
Sponsor:   United Therapeutics
Not yet recruiting

Diuretic Comparison Project

Condition:   Hypertension
Interventions:   Drug: Hydrochlorothiazide (HCTZ);   Drug: Chlorthalidone
Sponsor:   VA Office of Research and Development
Recruiting

TARGET BP I Clinical Trial

Condition:   Hypertension
Interventions:   Drug: Dehydrated alcohol;   Device: Peregrine System Kit (Sham Procedure)
Sponsor:   Ablative Solutions, Inc.
Recruiting

SPYRAL HTN-ON MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Recruiting

Pilot Evaluation of the Effect of Riboflavin Supplementation on Blood Pressure and Possible Effect Modification by the MTHFR C677T Genotype

Conditions:   High Blood Pressure;   MTHFR C677T Genotype
Interventions:   Dietary Supplement: Riboflavin;   Dietary Supplement: Placebo
Sponsors:   London School of Hygiene and Tropical Medicine;   University of Ulster
Active, not recruiting

Clinical Study of Pulsed, Inhaled Nitric Oxide Versus Placebo in Symptomatic Subjects With PAH

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Inhaled Nitric Oxide 75 mcg/kg IBW/hr;   Drug: Placebo
Sponsors:   Bellerophon Pulse Technologies;   Worldwide Clinical Trials
Terminated

Study of Netarsudil Ophthalmic Solution in Subjects With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT)

Condition:   Primary Open Angle Glaucoma or Ocular Hypertension
Interventions:   Drug: Netarsudil Ophthalmic Solution 0.02%;   Other: Placebo Comparator
Sponsor:   Aerie Pharmaceuticals
Completed

An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease;   Combined Pulmonary Fibrosis and Emphysema
Intervention:   Drug: Inhaled Treprostinil
Sponsor:   United Therapeutics
Enrolling by invitation

A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Patients With PH Due to COPD

Conditions:   Pulmonary Hypertension;   Chronic Obstructive Pulmonary Disease
Interventions:   Drug: Inhaled treprostinil solution;   Drug: Placebo solution
Sponsor:   United Therapeutics
Recruiting

Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease;   Combined Pulmonary Fibrosis and Emphysema
Interventions:   Drug: Inhaled Treprostinil;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting

A Dose Escalation Study to Assess the Safety and Efficacy of Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis or Sarcoidosis

Conditions:   Pulmonary Hypertension;   Pulmonary Fibrosis;   Sarcoidosis, Pulmonary
Intervention:   Combination Product: iNO
Sponsor:   Bellerophon
Recruiting

A Dose Escalation Study to Assess the Safety and Efficacy of Pulsed iNO in Subjects With Pulmonary Fibrosis

Conditions:   Pulmonary Fibrosis;   Pulmonary Hypertension
Interventions:   Drug: iNO;   Drug: Placebo
Sponsors:   Bellerophon Pulse Technologies;   Bellerophon
Recruiting

OPsumit USers Registry

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Opsumit (macitentan)
Sponsor:   Actelion
Recruiting

A Study to Evaluate the Long Term Safety of OTX-TP (Sustained Release Travoprost) Intracanalicular Insert

Condition:   Open Angle Glaucoma and Ocular Hypertension
Intervention:   Drug: Ophthalmic Insert
Sponsor:   Ocular Therapeutix, Inc.
Active, not recruiting

Metabolic and Cardiovascular Effects of Renal Denervation

Conditions:   Insulin Resistance;   Hypertension
Intervention:   Procedure: Renal denervation using Medtronic Symplicity System (mono-electrode)
Sponsor:   Umeå University
Terminated

Stress Management for High Blood Pressure

Condition:   Prehypertension
Interventions:   Behavioral: Mindfulness-Based Stress Reduction;   Behavioral: Stress Management Education;   Other: American Heart Association Recommended Self-Care
Sponsors:   Kent State University;   University of Pennsylvania;   Case Western Reserve University
Active, not recruiting

Hemodynamic Alterations in Liver Cirrhosis Validated by Non-invasive MR Compared to Invasive Assessment

Conditions:   Portal Hypertension;   Liver Diseases;   Liver Cirrhoses;   Cirrhosis
Intervention:  
Sponsor:   Hvidovre University Hospital
Recruiting

Effects of High Caffeine Content Coffee on Blood Pressure in Young Adults

Condition:   High Blood Pressure
Intervention:   Other: Coffee
Sponsor:   University of Rochester
Not yet recruiting

Study of SHP639 Eye Drops in Adults With High Eye Pressure or Primary Open-angle Glaucoma

Conditions:   Primary Open-angle Glaucoma (POAG);   Ocular Hypertension
Interventions:   Drug: SHP639 (n=60);   Drug: Placebo Comparator (n=24)
Sponsor:   Shire
Completed

Early Non-invasive Detection of CTEPH After Pulmonary Embolism

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Intervention:   Other: 'prediction score' and 'rule-out criteria'
Sponsor:   Leiden University Medical Center
Active, not recruiting

A Study of Single Dose MK-3614 (MK-3614-001)(COMPLETED)

Condition:   Hypertension
Interventions:   Drug: MK-3614;   Drug: Comparator: Placebo
Sponsor:   Merck Sharp & Dohme Corp.
Completed

24-Hour Ambulatory Blood Pressure Monitoring in Community Pharmacies

Condition:   Hypertension
Intervention:   Other: ABPM service by Pharmacists
Sponsor:   Virginia Commonwealth University
Recruiting

A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx, an Antisense Inhibitor Administered Subcutaneously to Hypertensive Subjects With Controlled Blood Pressure

Condition:   Mild Hypertension
Interventions:   Drug: IONIS-AGT-LRx;   Drug: Placebo
Sponsor:   Ionis Pharmaceuticals, Inc.
Active, not recruiting

Awareness Development and Usage of mHealth Technology Among Hypertensive Patients in a Rural Community of Bangladesh

Condition:   Hypertension
Intervention:   Behavioral: Mobile Health Technology (short message service)
Sponsor:   Hiroshima University
Completed

BedMed-Frail: Does the Potential Benefit of Bedtime Antihypertensive Prescribing Extend to Frail Populations?

Conditions:   Hypertension;   Dementia
Intervention:   Other: Bedtime administration of the participant's pre-existing antihypertensive medications
Sponsors:   University of Alberta;   Alberta Innovates Health Solutions;   Canadian Institutes of Health Research (CIHR);   EnACt
Not yet recruiting

ALTA TIPS: A 5-year Longitudinal Observational Study of Patients Undergoing TIPS Placement

Conditions:   Cirrhosis, Liver;   Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Intervention:  
Sponsors:   Northwestern University;   University of California, San Francisco;   Scripps Health;   University of Wisconsin, Madison;   University of Florida;   University of Arizona;   Stanford University;   Columbia University;   Weill Medical College of Cornell University;   Baylor Scott and White Health;   Mayo Clinic
Enrolling by invitation

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Condition:   Hypertension
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

Living Kidney Donor Study

Condition:   Living Kidney Donation
Intervention:  
Sponsors:   Lawson Health Research Institute;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting

A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome

Condition:   Cushing Syndrome
Interventions:   Drug: Relacorilant;   Other: Placebo
Sponsor:   Corcept Therapeutics
Recruiting

TIPS Plus Transvenous Obliteration for Gastric Varices

Conditions:   Cirrhosis, Liver;   Hypertension, Portal;   Esophageal and Gastric Varices;   Bleeding Gastric;   Encephalopathy
Intervention:   Device: TIPS-obliteration
Sponsor:   University of Illinois at Chicago
Recruiting

FibroScan™ in Pediatric Cholestatic Liver Disease (FORCE)

Conditions:   Biliary Atresia;   Alagille Syndrome;   Alpha1 Anti-Trypsin Deficiency;   Portal Hypertension;   Liver Fibrosis;   Cholestasis
Intervention:   Other: Liver Stiffness Measurement (LSM)
Sponsors:   Arbor Research Collaborative for Health;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting

The Efficacy and Safety of Cleviprex in Ventriculostomy Patients Requiring IV Antihypertensive Therapy

Conditions:   Hypertension;   Intracranial Hemorrhage;   Subarachnoid Hemorrhage
Intervention:   Drug: Clevidipine butyrate
Sponsors:   Methodist Healthcare;   The Medicines Company
Withdrawn

The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study

Conditions:   Mitral Regurgitation;   Pulmonary Hypertension
Interventions:   Diagnostic Test: Cardiac catheterisation;   Diagnostic Test: Cardiopulmonary exercise testing;   Diagnostic Test: Pulmonary function tests;   Diagnostic Test: Cardiac MRI;   Other: Quality of life survey;   Procedure: Mitral valve operation;   Procedure: Myocardial biopsies
Sponsor:   Imperial College London
Completed

Single Ascending Dose Study for Evaluation of Safety, Tolerability and Pharmacokinetics of L606

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: L606 (Liposomal Treprostinil) Inhalation Solution 51ug;   Device: L606 Inhalation System;   Other: Placebo Solution
Sponsors:   Pharmosa Biopharm Inc.;   PPD
Recruiting

A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

Conditions:   PAH;   Pulmonary Hypertension;   Pulmonary Arterial Hypertension;   Hypertension;   Connective Tissue Diseases;   Familial Primary Pulmonary Hypertension;   Vascular Diseases;   Cardiovascular Diseases;   Hypertension, Pulmonary;   Lung Diseases;   Respiratory Tract Disease
Intervention:   Drug: Ralinepag
Sponsor:   United Therapeutics
Enrolling by invitation

A Prospective Study of Living Kidney Donation

Condition:   Living Kidney Donors
Intervention:  
Sponsors:   Amit Garg;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting

Evaluation of 3D Overlay During Transjugular Intrahepatic Portosystemic Shunt (TIPS) Procedure

Condition:   Portal Hypertension
Intervention:   Procedure: TIPS with 3D Overlay
Sponsors:   Medical College of Wisconsin;   Siemens Medical Solutions
Completed

The Relationship Between HHcy and Contrast-induced Nephropathy in Hypertensive Patients After Coronary Artery Diagnosis and Treatment

Conditions:   Homocysteine;   Coronary Disease;   Angioplasty,Balloon,Coronary;   Contrast Media;   Nephropathy;   Hypertension
Interventions:   Drug: Enalapril Maleate Tablets(as the program-based antihypertension);   Drug: Enalapril Maleate and Folic Acid tablets(as the program-based antihypertension);   Drug: Placebo
Sponsor:   Fuling Central Hospital of Chongqing City
Completed

Open Label, Sequential-dose Study of PA5108 Latanoprost FA SR Ocular Implant for Mild-moderate Glaucoma

Condition:   Open Angle Glaucoma
Intervention:   Drug: PA5108 Latanoprost FA SR Ocular Implant
Sponsor:   PolyActiva Pty Ltd
Not yet recruiting

Isosorbide Mononitrate For Anti-Vascular Endothelial Growth Factor (VEGF) Induced Kidney Injury

Conditions:   Kidney Injury;   Proteinuria;   Hypertension
Interventions:   Drug: Isosorbide Mononitrate;   Drug: Placebo oral tablet
Sponsors:   The University of Texas Health Science Center, Houston;   National Kidney Foundation
Not yet recruiting

Heat Therapy and Omega 3 on Cardio-Metabolic Health

Condition:   Hypertension
Interventions:   Dietary Supplement: Omega 3;   Other: Placebo
Sponsor:   Texas Tech University
Recruiting

Comparison of the Medication Adherence of Patients Treated With Telmisartan/Hydrochlorothiazide or Telmisartan/Amlodipine Fixed Dose Combination (FDC) Versus Double-pill Combination Therapy in Real-world Japanese Therapeutic Practice

Condition:   Hypertension
Interventions:   Drug: subjects treated with telmisartan/hydrochlorothiazide;   Drug: Subjects treated with Telmisartan and amlodipine;   Drug: subjects treated with Telmisartan+hydrochlorothiazide double-pill combination group;   Drug: subjects treated with telmisartan+amlodipine double pill
Sponsor:   Boehringer Ingelheim
Not yet recruiting

Indian Ragas on Health - a Electrophysiological Study (RAGA-1)

Condition:   Hypertension
Intervention:   Other: Music Intervention
Sponsors:   MS Ramaiah Medical College & Hospitals;   Rajiv Gandhi University of Health Sciences
Completed

Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic Failure

Conditions:   Autonomic Nervous System Disorders;   Pure Autonomic Failure;   Shy-Drager Syndrome;   Orthostatic Hypotension, Dysautonomic
Interventions:   Drug: Angiotensin-(1-7);   Drug: Saline
Sponsor:   Vanderbilt University Medical Center
Recruiting

A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Conditions:   PAH;   Pulmonary Hypertension;   Pulmonary Arterial Hypertension;   Hypertension;   Connective Tissue Diseases;   Familial Primary Pulmonary Hypertension;   Vascular Diseases;   Cardiovascular Diseases;   Hypertension, Pulmonary;   Lung Diseases;   Respiratory Tract Disease
Interventions:   Drug: Ralinepag;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting

French Observatory of Congenital Ventricular Septal Defect With Pulmonary Overload

Condition:   Congenital Heart Disease
Intervention:  
Sponsor:   French Cardiology Society
Recruiting

Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC)

Conditions:   Liver Diseases;   Alagille Syndrome;   Alpha 1-Antitrypsin Deficiency
Intervention:  
Sponsors:   Arbor Research Collaborative for Health;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

VICIS - Vienna Cirrhosis Study

Conditions:   Liver Cirrhosis;   Portal Hypertension;   Ascites;   Variceal Hemorrhage;   Hepatic Encephalopathy
Intervention:  
Sponsor:   Medical University of Vienna
Recruiting

Collection of Samples From Pregnant Women for the Evaluation of Preeclampsia (Pre-E) Biomarkers

Conditions:   Preeclampsia;   Hypertension;   Proteinuria;   Thrombocytopenia;   Renal Insufficiency;   Impaired Liver Function;   Pulmonary Edema
Intervention:  
Sponsor:   Progenity, Inc.
Active, not recruiting

The Influence of Post-transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy

Conditions:   Portal Hypertension;   Hepatic Encephalopathy
Intervention:   Procedure: trans jugular intrahepatic portal systemic shunt
Sponsor:   Shanghai Zhongshan Hospital
Recruiting

The Diet Gout Trial

Conditions:   Gout;   Hyperuricemia
Intervention:   Other: Subsidy for food purchases and dietitian education
Sponsors:   Johns Hopkins University;   Massachusetts General Hospital;   Beth Israel Deaconess Medical Center;   Harvard Medical School;   Rheumatology Research Foundation
Completed

Early iNO for Oxidative Stress, Vascular Tone and Inflammation in Babies With Hypoxic Respiratory Failure

Conditions:   Persistent Fetal Circulation Syndrome;   Hypertension, Pulmonary, of Newborn, Persistent;   Persistent Pulmonary Hypertension of Newborn
Interventions:   Drug: Inhaled nitric oxide;   Drug: Nitrogen Gas;   Drug: Crossover iNO
Sponsors:   University of Florida;   Mallinckrodt
Recruiting

Placental Growth Factor Assessment of Women With Suspected Pre-eclampsia

Conditions:   Pre-eclampsia;   Pregnancy, High Risk;   Pregnancy Complications
Intervention:   Other: Maternal plasma PlGF quantification
Sponsors:   Irish Centre for Fetal and Neonatal Translational Research;   National Maternity Hospital, Ireland;   Rotunda Maternity Hospital, Dublin;   Coombe Women and Infants University Hospital;   University College Hospital Galway;   Royal Jubilee Maternity Hospital, Belfast;   Cork University Maternity Hospital, Cork;   Univerisy Maternity Hospital, Limerick;   University College Cork
Completed

Droxidopa / Pyridostigmine in Orthostatic Hypotension

Condition:   Orthostatic Hypotension
Interventions:   Drug: Droxidopa;   Drug: Pyridostigmine Bromide
Sponsor:   Mayo Clinic
Recruiting

Twice Against Thrice-weekly Hemodialysis

Condition:   Hemodialysis Complication
Intervention:   Procedure: Hemodialysis
Sponsor:   Saint-Joseph University
Recruiting

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

Conditions:   Adrenal Gland Neoplasm;   Hypertension;   Bone Diseases, Metabolic;   Cardiovascular Disease;   Hyperinsulinemia
Intervention:  
Sponsors:   National Human Genome Research Institute (NHGRI);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Interest in Electronic Applications for Patients With Glaucoma

Condition:   Glaucoma
Intervention:   Device: Interest in medical education through social media
Sponsor:   Wills Eye
Completed

Evaluation of an Electronic CKD Clinical Decision Support System (CDSS) in Clinical Care

Conditions:   Hypertension;   Renal Insufficiency, Chronic
Interventions:   Other: Clinical Decision Support System (CDSS);   Other: Clinic Decision Sup System + Pharmacist
Sponsor:   University of California, San Francisco
Active, not recruiting

To Compare the Effectiveness of Suvorexant vs Placebo on Sleep Pressure in Hypertensives With Insomnia

Conditions:   Hypertension;   Insomnia
Interventions:   Drug: suvorexant;   Other: Placebo
Sponsors:   Jichi Medical University;   Merck Sharp & Dohme Corp.;   Satt Co.,Ltd
Completed

The Impact of Mobile APP Intervention ( iCKD APP) on Chronic Kidney Disease Care

Conditions:   Chronic Kidney Disease;   Hypertension
Intervention:   Device: iCKD APP
Sponsor:   Kaohsiung Medical University Chung-Ho Memorial Hospital
Recruiting

Genetics of Type 2 Diabetes in West Africans

Conditions:   Hypertension;   Diabetes
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

Effects of a Novel Physical Exercise Program in Patients With Cirrhosis (the LFN-exercise Protocol)

Conditions:   Cirrhosis;   Portal Hypertension;   Exercise
Interventions:   Other: Exercise;   Other: nutritional therapy
Sponsors:   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran;   Universidad Nacional Autonoma de Mexico
Active, not recruiting

Losartan and Inflammation in Cystic Fibrosis

Condition:   Cystic Fibrosis
Interventions:   Drug: Losartan;   Drug: placebo
Sponsors:   University of Miami;   University of Alabama at Birmingham;   Children's Hospital Medical Center, Cincinnati;   University of Kansas Medical Center
Recruiting

S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer

Conditions:   Cardiotoxicity;   HER2/Neu Positive;   Metastatic Malignant Neoplasm in the Brain;   Recurrent Breast Carcinoma;   Stage IV Breast Cancer AJCC v6 and v7
Interventions:   Drug: Carvedilol;   Other: Laboratory Biomarker Analysis;   Other: Patient Observation
Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
Recruiting

Propranolol for Challenging Behaviors in Autism

Conditions:   Autism Spectrum Disorder;   Developmental Disability;   Aggression;   Self-Injurious Behavior;   Challenging Behavior
Intervention:   Drug: Propranolol
Sponsors:   Rutgers, The State University of New Jersey;   New Jersey Governor’s Council for Medical Research and Treatment of Autism;   New York State Institute for Basic Research
Recruiting

MRI to Assess the Effect of Non-selective Beta-blocker in Patients With Cirrhosis

Conditions:   Portal Hypertension;   Cirrhosis;   Esophageal Varices;   Gastric Varices Bleeding;   Varice Bleed;   Liver Diseases;   Liver Cirrhosis
Intervention:  
Sponsor:   Hvidovre University Hospital
Recruiting

Establishment of a Perinatal Database and a Bank of Biological Materials

Conditions:   Preterm Labor;   Preterm Birth;   Pregnancy
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed

Dietary Protein in Proteinuria

Conditions:   Kidney Insufficiency;   Diabete Mellitus;   Diabetes Mellitus, Type 2;   Diabetes Mellitus, Type 1;   Diabetes Complications;   Hypertension;   Glomerulonephritis;   Kidney Diseases;   Kidney Disease, Chronic
Interventions:   Other: High Animal Protein Diet;   Other: High Plant Protein Diet
Sponsors:   Jens Rikardt Andersen;   Nutricia, Inc.;   Nordsjaellands Hospital
Recruiting

A Trial of Cardiac Injections of iMP Cells During CABG Surgery

Condition:   Myocardial Fibrosis
Interventions:   Biological: iMP cells;   Other: Control injection
Sponsors:   Cell Therapy Ltd.;   Royal Brompton & Harefield NHS Foundation Trust
Not yet recruiting

Improved Cardiovascular Risk Reduction to Enhance Rural Primary Care

Conditions:   Diabetes Mellitus;   Hypertension;   Coronary Artery Disease;   Atrial Fibrillation;   Stroke
Interventions:   Other: PHCVRS Intervention;   Other: Personal Health Record
Sponsor:   Korey Kennelty
Completed

Dialectical Behavior Therapy for Pregnant Women

Condition:   Perinatal Depression
Intervention:   Behavioral: Dialectical Behavior Therapy (DBT) Skills Training
Sponsor:   Emory University
Not yet recruiting

Acromegaly & Sleep Apnoea

Condition:   Acromegaly
Intervention:  
Sponsor:   The Leeds Teaching Hospitals NHS Trust
Completed

Blood Vessel Study

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   National Institute of Environmental Health Sciences (NIEHS)
Completed

Stress Management to Support Women's Health

Conditions:   Hypertension;   Stress;   Cardiovascular Diseases
Interventions:   Behavioral: MBCT-T;   Behavioral: Usual Care
Sponsor:   NYU Langone Health
Recruiting

Treatment for Non-Alcoholic Fatty Liver With Different Doses of Vitamin E

Condition:   Fatty Liver
Interventions:   Drug: Vitamin E 200 IU/d;   Drug: Vitamin E 400 IU/d;   Drug: Vitamin E 800 IU/d;   Behavioral: Diet and Exercise
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting

Validation Study of an Advanced Blood Pressure Monitor

Conditions:   Atrial Fibrillation;   Hypertension;   Valvular Heart Disease
Interventions:   Diagnostic Test: BP measurement;   Diagnostic Test: AF detection;   Diagnostic Test: VHD detection
Sponsors:   Withings;   Clinact
Completed

Effects of Propranolol on Responses to Drug-Related Imagery Scripts

Condition:   Cocaine Dependence
Interventions:   Drug: Propranolol;   Drug: Placebo
Sponsor:   National Institute on Drug Abuse (NIDA)
Terminated

Danish Evaluation of Your Heart Forecast.

Conditions:   Risk Communication;   Cardiovascular Risk Factor
Intervention:   Other: Your Heart Forecast
Sponsors:   University of Southern Denmark;   Region of Southern Denmark;   Odense Patient Data Explorative Network;   ENIGMA Solutions Limited;   Lilly & Herbert Hansens Foundation;   The A. P. Møller and Chastine McKinney Møller Foundation
Enrolling by invitation

Arm-crank Exercise Training on Cardiovascular Function of Patients With Peripheral Artery Disease

Conditions:   Peripheral Arterial Disease;   Intermittent Claudication;   Hypertension
Interventions:   Other: Arm ergometer;   Other: Treadmill ergometer;   Other: Control group
Sponsors:   Hospital Israelita Albert Einstein;   University of Nove de Julho;   Northumbria University
Recruiting

Diagnosis of Pheochromocytoma

Conditions:   Pheochromocytoma;   Endocrine Disease;   Endocrine Diseases
Interventions:   Drug: Fluorodopamine;   Drug: F-18 Fluorodopa
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Clonidine for Relapse Prevention in Buprenorphine-Maintenance Patients

Condition:   Opioid-Related Disorders
Interventions:   Drug: Clonidine;   Drug: Placebo
Sponsor:   National Institute on Drug Abuse (NIDA)
Completed

A Multi-center Trial of IMPaCT CHW Support for Chronically-ill Patients

Conditions:   Hypertension;   Diabetes;   Obesity;   Tobacco Dependence
Interventions:   Behavioral: IMPaCT;   Other: Usual care
Sponsors:   University of Pennsylvania;   Patient-Centered Outcomes Research Institute
Completed

the Canadian Health Improvement Network to Upgrade Prevention Services

Condition:   Cardiovascular Disease
Intervention:   Other: Comprehensive e-health wellness program
Sponsor:   McGill University
Completed

Assessment of Compliance With European and French Guidelines for the Management of Dyslipidaemias

Condition:   Patient With Dyslipidemia
Intervention:   Other: Detection of patients with dyslipidemia
Sponsor:   University Hospital, Montpellier
Recruiting

CTEPH Identification an Standard Computerised Tomography Pulmonary Angiography in Pulmonary Embolism Patients

Conditions:   CTEPH;   Pulmonary Embolism;   Early Diagnosis
Intervention:   Diagnostic Test: The initial CTPA will be reviewed
Sponsors:   Leiden University Medical Center;   VU University Medical Center;   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Completed

Effects of a Plant-Based Diet on Insulin Requirements and Obesity Markers in Obese Adults With T2DM.

Conditions:   Diabetes Mellitus, Type 2;   Insulin Resistance;   Obesity;   Nutritional and Metabolic Disease
Interventions:   Behavioral: DASH;   Behavioral: Whole-Food, Plant-Based
Sponsor:   University of Rochester
Not yet recruiting

Eight Week Strength Training Reduces Blood Pressure of Middle Age Women

Conditions:   Blood Pressure;   Resistance Training;   Women
Intervention:   Other: Resistance trainining
Sponsor:   Universidade Regional do Cariri
Completed

The Influence of Time-Restricted Eating in Patients Metabolic Syndrome

Conditions:   Metabolic Syndrome;   Pre-Diabetes
Interventions:   Behavioral: Time Restricted Feeding + Standard of Care;   Behavioral: Standard of Care
Sponsors:   University of California, San Diego;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   Salk Institute for Biological Studies
Recruiting

The Effect of Transjugular Intraheptic Portosystemic Shunt (TIPS) on Gastrointestinal Motility and the Gut Microbiota

Condition:   Cirrhosis
Interventions:   Diagnostic Test: SMART Pill Pre-TIPS;   Diagnostic Test: SMART Pill Post TIPS
Sponsor:   NYU Langone Health
Recruiting

Vascular Effects of Mineralocorticoid Receptor Antagonism in Kidney Disease

Conditions:   Chronic Kidney Disease;   Albuminuria
Interventions:   Drug: Spironolactone;   Drug: Amiloride
Sponsors:   University of Alabama at Birmingham;   National Institutes of Health (NIH)
Recruiting

Cone Beam CT Guided Transbronchial Cryobiopsy

Condition:   ILD
Intervention:   Procedure: cone beam CT guided transbronchial cryobiopsy
Sponsor:   China-Japan Friendship Hospital
Recruiting

Fasciotens to Treat an Open Abdomen - a Prospective Cohort Study

Conditions:   Abdominal Compartment Syndrome;   Pancreatitis,Acute Necrotizing;   Intraabdominal Hypertension;   Peritonitis
Intervention:   Device: Fasciotens-Abdomen
Sponsors:   RWTH Aachen University;   Fasciotens GmbH
Recruiting

A Comparative Evaluation of a MPS Dressing and a CMC Dressing on Subjects With Lower Extremity Venous Ulcers

Condition:   Venous Leg Ulcer
Interventions:   Device: Marine polysaccharide dressing;   Device: Carboxymethylcellulose dressing
Sponsor:   Medline Industries
Not yet recruiting

Evaluation of Hemodynamic Parameters Following Transjugular Intrahepatic Portosystemic Shunt (TIPS)

Condition:   Refractory Ascites
Interventions:   Procedure: Study - Transjugular Intrahepatic Portosystemic Shunt (TIPS);   Procedure: Control - Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Sponsors:   Medical College of Wisconsin;   Radiological Society of North America
Not yet recruiting

Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function

Condition:   Cerebral Small Vessel Diseases
Interventions:   Drug: Amlodipine;   Drug: Losartan;   Drug: Atenolol
Sponsors:   Ludwig-Maximilians - University of Munich;   University of Edinburgh;   Maastricht University Medical Center;   UMC Utrecht;   University of Oxford
Recruiting

In-market Utilisation of Liraglutide Used for Weight Management in Europe

Conditions:   Metabolism and Nutrition Disorder;   Obesity
Intervention:   Drug: liraglutide
Sponsor:   Novo Nordisk A/S
Completed

Grape Polyphenols and Metabolic Syndrome

Condition:   Metabolic Syndrome, Protection Against
Intervention:   Dietary Supplement: Table Grape supplement
Sponsor:   Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Not yet recruiting

The Impact of Time Restricted Feeding (TRF) in Improving the Health of Patients With Metabolic Syndrome

Conditions:   Weight Loss;   Metabolic Syndrome;   Overweight and Obesity
Intervention:   Behavioral: Time Restricted Feeding
Sponsors:   University of California, San Diego;   Salk Institute for Biological Studies
Active, not recruiting

The Impact of a Diabetes Risk Prediction Model in Primary Care.

Conditions:   Type 2 Diabetes Mellitus;   Primary Prevention
Intervention:   Other: external validated risk prediction model
Sponsors:   German Diabetes Center;   Association of Statutory Health Insurance Physicians North Rhine;   German Institute of Human Nutrition
Enrolling by invitation

Follow-up Study of Late Effects of Periconceptional Folic Acid in Mothers and Offspring in the Community Intervention Program Population: The Chinese Children and Families Study

Conditions:   Pediatric Leukemia;   Other Pediatric Cancers
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Completed

Collection of Whole Blood Samples for the Evaluation of Preeclampsia (Pre-E) Biomarkers From Pregnant Women

Conditions:   Pre-Eclampsia;   Hypertension;   Proteinuria in Pregnancy;   Thrombocytopenia;   Renal Insufficiency;   Impaired Liver Function;   Pulmonary Edema;   Headache;   Visual Impairment
Intervention:   Other: Non-interventional study
Sponsor:   Progenity, Inc.
Active, not recruiting

Responsiveness Index Versus the RASS Based Method for Adjusting Sedation in Critically Ill Patients

Condition:   Critical Illness
Intervention:   Drug: Propofol
Sponsor:   Helsinki University Central Hospital
Completed

Berberine and Non-Alcoholic Fatty Liver Disease (NAFLD)

Condition:   Non-Alcoholic Fatty Liver Disease
Intervention:   Other: Berberine
Sponsor:   Lida Nejati
Completed

Weight Management Intervention for Youth and Young Adults With Autism Spectrum Disorder

Condition:   Autism Spectrum Disorder
Intervention:   Behavioral: Healthy Habits for Life
Sponsors:   University of Pittsburgh;   Massachusetts General Hospital
Recruiting

Artificial Intelligence Analysis of Initial Scan Evolution of Traumatic Brain Injured Patient to Predict Neurological Outcome

Condition:   Trauma, Brain
Intervention:   Radiation: CT scan
Sponsor:   University Hospital, Grenoble
Not yet recruiting

Anticonvulsant Mood Stabilizers, Antipsychotic Drugs and the Insulin Resistance Syndrome

Conditions:   Schizophrenia;   Schizoaffective Disorder;   Bipolar Disorder
Interventions:   Drug: ziprasidone vs. aripiprazole;   Drug: aripiprazole vs. ziprasidone
Sponsors:   Northwestern University;   National Alliance for Research on Schizophrenia and Depression;   Pfizer
Completed

Quantification of Elastin Markers Synthesis in Williams-Beuren Syndrome and 7q11.23 Micro-duplication Syndrome

Conditions:   Williams-Beuren Syndrome;   Micro-duplication 7q11.23 Syndrome;   Vasculopathy
Interventions:   Biological: Physical examination and Urine and blood samples;   Biological: Urine and blood samples
Sponsor:   Hospices Civils de Lyon
Not yet recruiting

Carbohydrate Restriction in Pregnant Women With Gestation Diabetes Mellitus

Condition:   Gestational Diabetes
Intervention:   Other: Low carbohydrate (130 g) diet
Sponsor:   Tel-Aviv Sourasky Medical Center
Recruiting

Obstructive Sleep Apnea, CPAP Treatment & Cognitive Ability in HIV

Conditions:   Hiv;   Obstructive Sleep Apnea;   Cognitive Change
Intervention:   Behavioral: CPAP intervention
Sponsors:   McGill University;   Vitalaire;   ResMed
Enrolling by invitation

Early Signs of Altitude Illness in Patients With COPD

Condition:   Chronic Obstructive Pulmonary Disease
Intervention:   Diagnostic Test: Structured self-monitoring during an altitude ascent and stay at high altitude
Sponsors:   University of Zurich;   National Center of Cardiology and Internal Medicine, Kyrgyzstan
Recruiting

Provider Supported Self-Help Cognitive Behavioral Therapy for Insomnia (Tele-Self CBTI)

Condition:   Insomnia Disorder
Interventions:   Behavioral: Tele-Self CBTI;   Other: Health Education Control
Sponsor:   VA Office of Research and Development
Not yet recruiting

Parecoxib as an Adjuvant to Scalp Nerve Blocks for Relief of Post-craniotomy Pain

Conditions:   Pain, Postoperative;   Neurosurgery
Interventions:   Drug: Scalp blocks with ropivacaine plus parecoxib;   Drug: Scalp blocks with ropivacaine and intravenous parecoxib;   Drug: Scalp blocks with ropivacaine and intravenous saline
Sponsor:   Beijing Tiantan Hospital
Not yet recruiting

Intravenous Versus Intramuscular Administration of Methylergonovine for Uterine Contraction in Cesarean Sections

Conditions:   Uterine Atony;   Uterine Tone Disorders;   Postpartum Hemorrhage
Intervention:   Drug: Methylergonovine
Sponsor:   Johns Hopkins University
Not yet recruiting

Integrating Online Weight Management With Primary Care Support

Condition:   Obesity
Interventions:   Behavioral: Online weight management program;   Behavioral: Population health management support
Sponsors:   Brigham and Women's Hospital;   Patient-Centered Outcomes Research Institute
Completed

The NIH Exercise Therapy for Advanced Lung Disease Trials: Response and Adaptation to Aerobic Exercise in Patients With Interstitial Lung Disease

Conditions:   Interstitial Lung Disease;   Idiopathic Pulmonary Fibrosis;   Interstitial Pneumonitis;   Desquamative Interstitial Pneumonia
Interventions:   Other: Aerobic Exercise Training (AET);   Other: No exercise
Sponsors:   National Institutes of Health Clinical Center (CC);   George Mason University;   Inova Fairfax Hospital
Recruiting

Thrombolytic and Interventional Treatment of Pulmonary Embolism

Condition:   Pulmonary Embolism
Intervention:   Procedure: interventional treatment in pulmonary
Sponsor:   First Affiliated Hospital Xi'an Jiaotong University
Not yet recruiting

Individualized Cognitive Training in HIV

Conditions:   HIV-Associated Cognitive Motor Complex;   Aging;   Cognitive Impairment;   Cognitive Decline;   Attention Impaired;   Processing, Visual Spatial;   Cognitive Deficit in Attention;   Cognitive Disorder in Remission
Interventions:   Behavioral: Individualized Cognitive Training;   Other: No-Contact Control
Sponsors:   University of Alabama at Birmingham;   National Institute of Nursing Research (NINR)
Completed

Lipidomics Screening of Anti-inflammatory Drugs and Drug Candidates in Vitro - Part A

Condition:   Healthy
Intervention:   Procedure: Blood draw
Sponsors:   University of Pennsylvania;   Eli Lilly and Company
Active, not recruiting

Clinical Laboratory Evaluation of Chronic Autonomic Failure

Conditions:   Parkinson's Disease;   Multiple System Atrophy;   Autonomic Failure
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Influence of ABO Blood Group on the Risk of Complications in Alcoholic or Viral C Cirrhosis?

Condition:   Alcoholic or Viral C Compensated Cirrhosis
Intervention:   Genetic: G20210A prothrombin gene mutation and Factor 5 Leiden mutation
Sponsors:   University Hospital, Caen;   Thong DAO;   Annie BOREL-DERLON;   Nathalie GANNE-CARRIE;   Pierre NAHON;   Sylvie CHEVRET
Not yet recruiting

Automated Extracranial Internal Carotid Artery Ultrasound Sensor for Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Intervention:   Device: Automated extracranial internal carotid artery ultrasound sensor
Sponsor:   University of Michigan
Withdrawn

Decrease in Blood Pressure in PARQVE

Conditions:   Knee Osteoarthritis;   Blood Pressure
Interventions:   Behavioral: ABPM;   Behavioral: The arterial stiffness and endothelial reactivity;   Behavioral: Euroqol EQ-5D-5L;   Behavioral: Lectures about knee OA;   Behavioral: Continuous intensity exercise;   Behavioral: Exercises with varying intensity and interval
Sponsor:   University of Sao Paulo General Hospital
Not yet recruiting

Relationship of Oral Status to Coronary Artery Disease

Conditions:   Coronary Artery Disease;   Periodontal Diseases
Intervention:   Other: radiographic evaluations were done
Sponsors:   Baskent University;   Ankara University
Completed

Habit Formation in Older Adults

Condition:   Older Adults
Intervention:   Behavioral: Everyday Meaningful Activities (EMA) intervention
Sponsor:   East Carolina University
Recruiting

Reference Values for Plasma Catechols

Conditions:   Healthy Volunteers;   Normal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

A Multicenter Phase 2 Single-arm Proof-of-concept Trial to Assess the Efficacy and Safety of Ustekinumab in Association With Prednisone for the Treatment of Non-infectious Severe Uveitis (NISU)

Condition:   Patients With Newly Diagnosed Active NISU
Interventions:   Drug: prednisone and ustekinumab treatment;   Other: Ophthalmologic examination;   Other: Questionnaires;   Biological: Blood samples
Sponsor:   Centre Hospitalier Universitaire Dijon
Recruiting

Effects of Nocturnal Nasal Oxygen on Biomarkers in Sleep Apnea Patients With Heart Failure

Conditions:   Sleep Apnea;   Heart Failure
Interventions:   Procedure: Nocturnal nasal oxygen;   Other: No nasal oxygen
Sponsor:   University of Maryland, Baltimore
Terminated

Co-administration of Thiamine Pyrophosphate and Metformin in Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Dietary Supplement: Thiamine pyrophosphate;   Other: Placebo;   Drug: Metformin
Sponsors:   Laboratorios Manuell SA;   Universidad Nacional Autonoma de Mexico
Recruiting

Post-prandial Effects of Extra Virgin Olive Oil on Endothelial Function in Adults at Risk for Type 2 Diabetes

Condition:   Type 2 Diabetes
Interventions:   Other: Extra Virgin Olive Oil;   Other: Refined Olive Oil
Sponsor:   Griffin Hospital
Recruiting

Efficacy of Treatment for Gestational Diabetes Diagnosed by the IADPSG Criteria.

Condition:   Gestational Diabetes
Intervention:   Behavioral: Medical Nutrition Therapy
Sponsor:   Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
Recruiting

Cardiology Biobank Registry

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   Emory University
Recruiting

Study of the Disease Process of Lymphangioleiomyomatosis

Conditions:   Lung Disease;   Pneumothorax;   Tuberous Sclerosis;   Lymphangioleiomyomatosis
Intervention:   Device: Toshibia Aquilion One CT
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Metabolic Effects of Angiotensin-(1-7)

Conditions:   Obesity;   Insulin Resistance;   Hypertension;   Metabolic Cardiovascular Syndrome
Interventions:   Drug: Angiotensin-(1-7);   Drug: Saline
Sponsor:   Vanderbilt University
Recruiting

An Urban Trail Network and Cardiovascular Disease: A Natural Experiment

Conditions:   Cardiovascular Diseases;   Cardiovascular Risk Factor;   Diabetes Mellitus
Intervention:   Other: Urban Trail
Sponsors:   University of Manitoba;   St. Michael's Hospital, Toronto;   Ontario Agency for Health Protection and Promotion;   University of Toronto
Recruiting

Safe Kidney Care Cohort Study

Condition:   Chronic Kidney Disease
Intervention:  
Sponsors:   University of Maryland, Baltimore;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Aneurysmal Subarachnoid Hemorrhage and Superior Mesenteric Artery Flow Study

Condition:   Intracranial Aneurysm
Intervention:   Device: Ultrasound
Sponsor:   University of Florida
Completed

Skin Sympathetic Nerve Activity and Sympathetic Tone

Conditions:   Nerve; Disorder, Sympathetic;   Healthy
Intervention:  
Sponsor:   Kaohsiung Medical University Chung-Ho Memorial Hospital
Enrolling by invitation

The Platinum Study Comparison Group

Condition:   Testicular Neoplasms
Intervention:   Behavioral: Questionnaire
Sponsor:   Lawrence Einhorn
Active, not recruiting

Biomarkers of Acute Stroke in Clinic

Conditions:   Ischemic Stroke;   Ischemia;   Atrial Fibrillation;   Transient Ischemic Attack;   Transient Cerebrovascular Events;   Thrombotic Stroke;   Stroke;   Stroke, Acute;   Stroke, Ischemic;   Stroke, Complication;   Stroke of Basilar Artery;   Atherosclerosis;   Atheroma;   Cardioembolic Stroke;   Cardiomyopathies;   Cardiovascular Stroke;   Thromboembolism
Intervention:   Diagnostic Test: ISCDX blood test
Sponsor:   Ischemia Care LLC
Not yet recruiting

Response of the Gut Microbiome and Circulating Metabolome to Diet in Children: Ancillary Study to KIDFIT (NCT03405246)

Conditions:   Gastrointestinal Microbiome;   Metabolome;   Pediatric Obesity;   Dietary Approaches to Stop Hypertension
Interventions:   Behavioral: KIDFIT Healthy;   Behavioral: KIDFIT Safe
Sponsors:   Northwestern University;   American Heart Association;   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation

Patient Outcomes and Valve Performance After Surgical Aortic Valve Replacement With the INSPIRIS RESILIA Aortic Valve

Condition:   Cardiovascular Diseases
Intervention:   Device: INSPIRIS RESILIA Aortic Valve™
Sponsors:   Institut für Pharmakologie und Präventive Medizin;   Edwards Lifesciences
Not yet recruiting

Non-Invasive and Non-Contact Intracranial Pressure Waveform Recording Using Dynamic Video Ophthalmoscopy

Condition:   Intracranial Pressure Increase
Intervention:   Device: Video ophthalmoscope
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Not yet recruiting

Intracranial Pressure in Monopolar and Bipolar Hysteroscopy

Condition:   Intracranial Pressure Increase
Interventions:   Procedure: Monopolar hysteroscopy;   Procedure: Bipolar hysteroscopy
Sponsor:   Kanuni Sultan Suleyman Training and Research Hospital
Recruiting

Longitudinal Study of Mitochondrial Hepatopathies

Conditions:   Acute Liver Failure;   Mitochondrial Diseases;   End Stage Liver Disease;   Respiratory Chain Deficiencies, Mitochondrial;   Disorder of Fatty Acid Oxidation
Intervention:  
Sponsors:   Arbor Research Collaborative for Health;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   University of Michigan
Recruiting

Magnetic Resonance Imaging in High Risk Patients for the Development of Diffuse Idiopathic Skeletal Hyperostosis (DISH)

Conditions:   Hyperostosis, Diffuse Idiopathic Skeletal;   Metabolic Syndrome;   Diabetes Mellitus
Interventions:   Diagnostic Test: Thoracic spine x-rays+whole spine MRI;   Diagnostic Test: blood tests;   Other: constitutional and demographic data collection
Sponsors:   HaEmek Medical Center, Israel;   The Chaim Sheba Medical Center
Recruiting

Characteristics of Marrow Fatty Cells in the Ageing of Bone and Joints, Osteoarthritis and Osteoporosis

Conditions:   Osteoarthritis, Knee;   Prosthesis User
Intervention:   Procedure: tissue
Sponsors:   University Hospital, Lille;   MSDAVENIR Foundation
Not yet recruiting

Risk Factors and Impact of Anesthesia Techniques on Myocardial Infarction Following Transurethral Resection of the Prostate

Conditions:   Anesthesia;   Transurethral Resection of Prostate Syndrome;   Myocardial Infarction
Intervention:   Other: general anesthesia or neuraxial anesthesia
Sponsor:   Chang Gung Memorial Hospital
Completed

Prevention of Coronary Heart Disease in Morbidly Obese Patients

Conditions:   Morbid Obesity;   Hypertension;   Type 2 DM;   Obstructive Sleep Apnea;   Osteoarthrosis
Interventions:   Procedure: Bariatric Surgery;   Behavioral: Conservative Treatment:
Sponsors:   The Hospital of Vestfold;   Oslo University Hospital
Active, not recruiting

Vienna Vascular Liver Disease Study

Conditions:   Vascular Liver Disease;   Portal Vein Thrombosis;   Budd-Chiari Syndrome;   Non-Cirrhotic Portal Hypertension;   Rendu Osler Weber;   Cardiac Cirrhosis
Intervention:  
Sponsor:   Medical University of Vienna
Recruiting

Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese Women

Conditions:   Atherosclerosis;   Diabetes Mellitus;   Obesity;   Dyslipidemia;   Hypertension
Interventions:   Behavioral: Exercise;   Behavioral: Weight Loss
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

The Effects of Changing Light Levels on Contrast Sensitivity in Patients With Glaucoma

Condition:   Glaucoma
Intervention:  
Sponsor:   Portsmouth Hospitals NHS Trust
Recruiting

Phosphodiesterase Inhibitors in Glaucoma Study (PhiGS)

Condition:   Glaucoma
Intervention:   Drug: Sildenafil 100mg
Sponsor:   Imperial College London
Recruiting

IOP Reduction and Complications of Polymethyl Methacrylate GDD on Glaucoma Patient

Condition:   Glaucoma Eye
Intervention:   Procedure: Glaucoma Implant
Sponsors:   Indonesia University;   Fakultas Kedokteran Universitas Indonesia;   Dr Cipto Mangunkusumo General Hospital;   Institut Pertanian Bogor
Recruiting

Study of Neurotidine® Intake on Life Quality of Patients With Glaucoma

Condition:   Glaucoma
Interventions:   Other: Food for special medical purposes: Neurotidine®;   Other: Placebo
Sponsor:   Omikron Italia S.r.l.
Recruiting

Macular Pigment and Visual Performance in Glaucoma Patients

Condition:   Glaucoma
Interventions:   Drug: Lutein, zeaxanthin and mesozeaxanthin;   Other: Placebo
Sponsors:   Felipe Medeiros, MD;   Heidelberg Engineering GmbH;   MacuHealth LP;   Industrial Orgánica S.A. de C.V.
Enrolling by invitation

Caffeine Consumption in Glaucoma Patients and Healthy Subjects

Condition:   Glaucoma, Primary Open Angle
Intervention:   Dietary Supplement: Caffeine tablet
Sponsor:   Wills Eye
Recruiting

Comparative Study of Psychology and Glaucoma Knowledge in Glaucoma Day-ward Patients Inpatients

Condition:   Glaucoma
Interventions:   Other: randomized to day ward;   Other: randomized to inpaitent
Sponsor:   Zhongshan Ophthalmic Center, Sun Yat-sen University
Completed

Improve Glaucoma Medication Adherence

Condition:   Glaucoma
Interventions:   Behavioral: Educational - glaucoma;   Behavioral: Dose monitoring and reminder;   Behavioral: Educational - general;   Behavioral: Dose monitoring
Sponsor:   VA Office of Research and Development
Active, not recruiting

Anterior Segment Imaging With Ultrahigh-resolution OCT in Patients With Glaucoma and PEX - a Pilot Study

Condition:   Glaucoma
Intervention:   Drug: Pilocarpine
Sponsor:   Medical University of Vienna
Recruiting

Preserve-Transplant Study

Conditions:   Acidosis;   Renal Insufficiency;   Kidney Transplantation
Interventions:   Drug: Nephrotrans;   Other: Placebo
Sponsor:   University of Zurich
Active, not recruiting

Steroids After Laser Trabeculoplasty for Glaucoma

Condition:   Glaucoma
Interventions:   Drug: Prednisolone 1%;   Drug: Ketorolac;   Drug: Artificial Tears
Sponsors:   Stanford University;   Bascom Palmer Eye Institute;   University of Pittsburgh Medical Center
Completed

Clinical and Molecular Studies in Families With Glaucoma and Related Diseases

Condition:   Glaucoma
Intervention:  
Sponsor:   National Eye Institute (NEI)
Completed

Risk Prediction Models for Adverse Maternal and Neonatal Outcomes in Preeclampsia

Condition:   Severe Preeclampsia
Intervention:   Behavioral: Observational
Sponsor:   Mpilo Central Hospital
Recruiting

Optic Nerve Sheath Diameter in Preeclampsia

Condition:   Pre-Eclampsia
Intervention:   Diagnostic Test: Optic nerve sheath diameter measurement
Sponsor:   Kanuni Sultan Suleyman Training and Research Hospital
Recruiting

Neuroprognostication Using Optic Nerve Sheath Diameter

Conditions:   Heart Arrest;   Intracranial Pressure Increase
Intervention:   Other: Ocular ultrasound
Sponsors:   TriHealth Inc.;   TriHealth Hatton Research Institute
Recruiting

DEMAND - Multifactorial Study to Reduce Dementia in People With Type 2 Diabetes

Conditions:   Type 2 Diabetes Mellitus;   Mild Cognitive Impairment
Interventions:   Dietary Supplement: mediterranean diet;   Behavioral: individualized fitness program;   Other: recommended modified pharmacological treatment
Sponsors:   Umeå University;   Uppsala University
Not yet recruiting

MRI to Assess the Effect of Terlipressin in Patients With Acute Hepatorenal Syndrome (HRS-AKI)

Conditions:   Hepato-Renal Syndrome;   Portal Hypertension;   Acute Kidney Injury;   Liver Diseases;   Liver Cirrhoses;   Cirrhosis Cardiac;   Cirrhosis
Intervention:  
Sponsor:   Hvidovre University Hospital
Recruiting

Wireless Physiologic Monitoring in Postpartum Women

Conditions:   Maternal Death During Childbirth;   Pregnancy Complications
Intervention:   Combination Product: Wireless physiologic monitoring
Sponsors:   Massachusetts General Hospital;   Mbarara University of Science and Technology
Not yet recruiting

CTSI Pilot: Improving Adherence to Diabetic Diet

Conditions:   Diabetes Mellitus, Type 2;   Diet, Healthy;   Pre-diabetes
Interventions:   Behavioral: Online - use of online grocery shopping platform;   Behavioral: Default - use of online grocery shopping platform with default shopping carts
Sponsor:   State University of New York at Buffalo
Not yet recruiting

Virtual Visits at Brigham and Women's Hospital

Conditions:   Heart Failure;   Hypertension;   Diabetes Mellitus;   Stroke;   BPH;   Hyperlipidemia
Intervention:   Other: Virtual Visit
Sponsor:   Brigham and Women's Hospital
Enrolling by invitation

Progesterone Versus Progesterone Plus Dydrogesterone in FET

Condition:   Infertility
Interventions:   Drug: Micronized Progesterone;   Drug: Micronized progesterone plus dydrogesterone
Sponsor:   Mỹ Đức Hospital
Recruiting

Safety and Efficacy Study of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-7902-006/E7080-G000-315/LEAP-006)

Condition:   Nonsquamous Non-small Cell Lung Cancer
Interventions:   Biological: Pembrolizumab;   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Pemetrexed;   Drug: Lenvatinib;   Drug: Placebo matching lenvatinib
Sponsors:   Merck Sharp & Dohme Corp.;   Eisai Inc.
Recruiting

Culturally-Adapted Diet for Puerto Rican Adults

Conditions:   Diabetes Mellitus, Type 2;   Obesity;   Hypertension;   Dyslipidemias;   High Triglycerides;   High Blood Glucose;   Abdominal Obesity
Interventions:   Behavioral: Culturally tailored food and diet advice;   Behavioral: Standard healthy eating advice
Sponsors:   Harvard School of Public Health;   FDI Clinical Research
Recruiting

Roxadustat in the Treatment of Anemia in Chronic Kidney Disease (CKD) Patients, Not on Dialysis, in Comparison to Darbepoetin Alfa

Condition:   Anemia in Chronic Kidney Disease in Non-dialysis Patients
Interventions:   Drug: Roxadustat;   Drug: darbepoetin alfa
Sponsors:   Astellas Pharma Europe B.V.;   FibroGen
Active, not recruiting

Supplemental Calcium in Overweight People

Condition:   Obesity
Interventions:   Drug: Calcium supplement;   Drug: Placebo
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   Office of Dietary Supplements (ODS)
Completed

Steroids and/ or Non-steroidal Anti-inflammatory Drugs in the Postoperative Regime After Trabeculectomy.

Condition:   Glaucoma
Interventions:   Drug: Voltaren Ophtha 1 mg/ml, GSK;   Drug: Monopex 1 mg/ml, Théa
Sponsor:   Rigshospitalet, Denmark
Recruiting

Natural History of Sickle Cell Disease

Condition:   Pain Crisis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

An Efficacy, Safety, and Tolerability Study Comparing Dolutegravir (DTG) Plus Lamivudine (3TC) With Dolutegravir Plus Tenofovir/Emtricitabine in Treatment naïve HIV Infected Subjects (Gemini 2)

Conditions:   Infection, Human Immunodeficiency Virus;   HIV Infections
Interventions:   Drug: Dolutegravir (DTG);   Drug: Lamivudine (3TC);   Drug: Tenofovir disoproxil fumarate/Emtricitabine (TDF/FTC FDC)
Sponsors:   ViiV Healthcare;   GlaxoSmithKline
Active, not recruiting

Clinical Study of the BARD® COVERA™ Arteriovenous (AV) Stent Graft in AV Graft Patients (AVeVA)

Conditions:   Stenosis;   Restenosis
Intervention:   Device: Covera(TM) Vascular Covered Stent
Sponsor:   C. R. Bard
Completed

Trial to Evaluate Reduction in Inflammation in Patients With Advanced Chronic Renal Disease Utilizing Antibody Mediated IL-6 Inhibition

Conditions:   Chronic Kidney Diseases;   Inflammation
Intervention:   Biological: Ziltivekimab
Sponsor:   Corvidia Therapeutics
Recruiting

An Efficacy, Safety, and Tolerability Study Comparing Dolutegravir Plus Lamivudine With Dolutegravir Plus Tenofovir/Emtricitabine in Treatment naïve HIV Infected Subjects (Gemini 1)

Conditions:   Infection, Human Immunodeficiency Virus;   HIV Infections
Interventions:   Drug: Dolutegravir (DTG);   Drug: Lamivudine (3TC);   Drug: Tenofovir disoproxil fumarate/Emtricitabine (TDF/FTC FDC)
Sponsors:   ViiV Healthcare;   PPD;   GlaxoSmithKline
Active, not recruiting

Carbetocin vs. Oxytocin at Elective Cesarean Section

Condition:   Postpartum Hemorrhage
Interventions:   Drug: Carbetocin;   Drug: Oxytocin
Sponsor:   Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Recruiting

Liver Immunosuppression Free Trial

Condition:   Transplantation, Liver
Interventions:   Genetic: Biomarker;   Drug: Tacrolimus, cyclosporine and/or mycophenolic acid, mycophenolate mofetil or azathioprine
Sponsors:   King's College London;   King's College Hospital NHS Trust;   National Institute for Health Research, United Kingdom
Active, not recruiting

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Immunosuppressant Regimens for Living Fetuses Study

Conditions:   Undifferentiated Connective Tissue Disease;   Recurrent Pregnancy Loss
Interventions:   Drug: Prednisone;   Drug: Hydroxychloroquine;   Drug: Aspirin;   Drug: low molecular weight heparin
Sponsors:   RenJi Hospital;   The First Affiliated Hospital of Anhui Medical University;   China-Japan Union Hospital, Jilin University;   Wuxi No. 2 People's Hospital;   The First Affiliated Hospital with Nanjing Medical University;   Xiangya Hospital of Central South University
Recruiting

Effects of Maintaining Steady Albumin Levels by Targeted Albumin Therapy (TAT 4) on Survival and Liver Related Complications in Cirrhosis With Ascites and Low Serum Albumin Level.

Condition:   Liver Cirrhosis
Interventions:   Drug: ALB Protein, Human;   Other: placebo
Sponsor:   Institute of Liver and Biliary Sciences, India
Not yet recruiting

Influence of HFNO on Spontaneous Ventilation in Patients of Different ASA Risk During Analgo-sedation for Vitrectomy

Conditions:   Noninvasive Ventilation;   Respiratory Insufficiency;   Moderate Sedation;   Hypoxia;   Airway Management;   Vitrectomy
Interventions:   Device: Low-flow nasal oxygenation (LFNO) ASA I;   Device: Low-flow nasal oxygenation (LFNO) ASA II;   Device: Low-flow nasal oxygenation (LFNO) ASA III;   Device: High-flow nasal oxygenation (HFNO) ASA I;   Device: High-flow nasal oxygenation (HFNO) ASAII;   Device: High-flow nasal oxygenation (HFNO) ASA III
Sponsors:   University of Split, School of Medicine;   Clinical Hospital Centre Zagreb
Recruiting

Effect of HFNO on Spontaneous Ventilation in Obese Patients During Analgo-sedation for Vitrectomy

Conditions:   Sedation Complication;   Obesity;   Hypoxic Respiratory Failure;   Airway Obstruction, Nasal;   Respiratory Insufficiency;   Apnea
Interventions:   Device: Device: low-flow nasal oxygenation (LFNO) 18Sponsors:   University of Split, School of Medicine;   Clinical Hospital Centre Zagreb
Recruiting

A Study in Maintenance Kidney Transplant Recipients Following Conversion to Nulojix® (Belatacept)-Based

Condition:   Kidney Transplantation
Interventions:   Drug: Belatacept;   Drug: Tacrolimus;   Drug: Cyclosporine
Sponsor:   Bristol-Myers Squibb
Active, not recruiting

A Study to Assess the Efficacy and Safety of Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)

Condition:   Duchenne Muscular Dystrophy
Interventions:   Drug: Vamorolone;   Drug: Prednisone;   Other: Placebo
Sponsors:   ReveraGen BioPharma, Inc.;   European Union;   Cooperative International Neuromuscular Research Group;   Newcastle University;   University of Pittsburgh
Recruiting

Research Study Comparing Insulin Degludec to Insulin Detemir, Together With Insulin Aspart, in Pregnant Women With Type 1 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 1
Interventions:   Drug: Insulin degludec;   Drug: Insulin Aspart;   Drug: Insulin detemir
Sponsor:   Novo Nordisk A/S
Recruiting

DISCOVER Global Registry

Condition:   Type 2 Diabetes
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Individualized Physical Activity and Carotid Plaque Instability

Condition:   Carotid Atherosclerosis
Interventions:   Device: individualized home-based physical activity;   Other: MRI;   Biological: blood sampling;   Other: Questionnaires;   Other: 6-minute walk test
Sponsor:   Hospices Civils de Lyon
Not yet recruiting

Evaluation of the Million Hearts CVD Risk Reduction Model

Condition:   Cardiovascular Diseases
Interventions:   Other: Enrollment in the Million Hearts CVD Risk Reduction Model;   Other: Enrollment in control provider organizations
Sponsors:   Mathematica Policy Research, Inc.;   Centers for Medicare and Medicaid Services;   RAND
Enrolling by invitation

End-stage Renal Disease (ESRD) Pilot Study

Condition:   Renal Dialysis
Interventions:   Drug: BAY1213790;   Drug: 0.9% sodium chloride solution
Sponsor:   Bayer
Recruiting

Targeting Obesity to Optimize Health in Cardiac Rehab (TOPCARE)

Conditions:   Obesity;   Weight Loss;   CHD - Coronary Heart Disease
Interventions:   Other: Exercise;   Behavioral: Health Education;   Other: Exercise Compliance;   Dietary Supplement: Calorie-Restricted Diet;   Behavioral: Behavioral Modification;   Other: Weight-Loss Compliance;   Other: Dietary Counseling
Sponsors:   Wake Forest University Health Sciences;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

PRedictOrs, PHEnotypes and Timing of Obstructive Sleep Apnea in Acute Coronary Syndrome

Conditions:   ST Elevated Myocardial Infarction;   Sleep-Disordered Breathing;   Sleep;   NSTEMI - Non-ST Segment Elevation MI
Intervention:   Diagnostic Test: Polygraphy
Sponsor:   Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Recruiting

Pharmacokinetics-pharmacodynamics and Safety of Dexmedetomidine in Children

Conditions:   Intensive Care Unit;   Postoperative Care
Intervention:   Drug: Dexmedetomidine Hydrochloride
Sponsors:   Seoul National University Hospital;   Ministry of Food and Drug Safety, Korea
Recruiting

International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Coronary Artery Disease;   Heart Diseases;   Myocardial Ischemia
Interventions:   Procedure: cardiac catheterization;   Procedure: coronary artery bypass graft surgery;   Procedure: percutaneous coronary intervention;   Behavioral: Lifestyle;   Drug: Medication
Sponsors:   NYU Langone Health;   New York University;   Stanford University;   National Heart, Lung, and Blood Institute (NHLBI);   Albany Stratton VA Medical Center;   Cedars-Sinai Medical Center;   Columbia University;   Duke University;   East Carolina University;   Emory University;   Harvard University;   Massachusetts General Hospital;   Montreal Heart Institute;   University of British Columbia;   University of Missouri, Kansas City;   Vanderbilt University
Active, not recruiting

EMPA-KIDNEY (The Study of Heart and Kidney Protection With Empagliflozin)

Condition:   Chronic Kidney Disease
Interventions:   Drug: Empagliflozin;   Drug: Matching placebo
Sponsors:   Boehringer Ingelheim;   Medical Research Council Population Health Research Unit, CTSU, University of Oxford (academic lead);   Eli Lilly and Company
Recruiting

Mechanisms of Cerebrovascular Control

Condition:   Metabolic Syndrome X
Interventions:   Drug: NOS Inhibition;   Drug: ET-1 Inhibition;   Drug: NOS Inhibition Placebo;   Device: 3 Tesla MRI;   Device: Intravenous Catheter;   Other: Oral Glucose Tolerance Test;   Drug: ET-1 Inhibition Placebo
Sponsor:   University of Wisconsin, Madison
Recruiting

A Study of Vonapanitase (PRT-201) Administered Immediately After Radiocephalic Arteriovenous Fistula(AVF) Creation in Patients With Chronic Kidney Disease (CKD) (PATENCY-2)

Condition:   Chronic Kidney Disease
Interventions:   Drug: Vonapanitase;   Drug: Placebo
Sponsor:   Proteon Therapeutics
Completed

EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)

Condition:   Heart Failure
Interventions:   Drug: Empagliflozin;   Drug: Placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting

EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)

Condition:   Heart Failure
Interventions:   Drug: Empagliflozin;   Drug: Placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting

Safety and Efficacy Study of IFX-1 in add-on to Standard of Care in Granulomatosis With Polyangiitis (GPA) and Microscopic Polyangiitis (MPA)

Conditions:   Granulomatosis With Polyangiitis (GPA);   Microscopic Polyangiitis (MPA)
Interventions:   Drug: IFX-1;   Drug: Placebo
Sponsors:   InflaRx GmbH;   Iqvia Pty Ltd
Recruiting

A Study to Evaluate Efficacy and Safety of Anakinra in the Treatment of Acute Gouty Arthritis

Condition:   Acute Gouty Arthritis
Interventions:   Drug: Anakinra 100 mg;   Drug: Triamcinolone Acetonide 40 mg;   Drug: Placebo to Anakinra 100 mg;   Drug: Placebo to Triamcinolone Acetonide 40 mg
Sponsor:   Swedish Orphan Biovitrum
Active, not recruiting

A Study to Evaluate the Long-term Safety and Tolerability of Lucerastat in Adult Subjects With Fabry Disease

Condition:   Fabry Disease
Intervention:   Drug: Lucerastat
Sponsor:   Idorsia Pharmaceuticals Ltd.
Recruiting

Efficacy and Safety of Lucerastat Oral Monotherapy in Adult Subjects With Fabry Disease

Condition:   Fabry Disease
Interventions:   Drug: Lucerastat;   Drug: Placebo
Sponsor:   Idorsia Pharmaceuticals Ltd.
Recruiting

Endothelial Function Guided Therapy in Patients With Non-obstructive Coronary Artery Disease

Condition:   Non-obstructive Coronary Artery Disease
Intervention:   Other: Endothelial function guided therapy
Sponsors:   Peking University;   Mayo Clinic;   Peking University Shougang Hospital
Recruiting

The Best Timing of Delivery in Women With GDM Study

Conditions:   Gestational Diabetes;   Induction of Labor Affected Fetus / Newborn
Intervention:   Procedure: New procedure
Sponsor:   Peking University First Hospital
Recruiting

Mediterranean Lifestyle Program in the Prevention and Treatment of Depression

Condition:   Depression
Interventions:   Behavioral: Mediterranean lifestyles (ML);   Behavioral: Information communication technologies (ICTs)
Sponsor:   Instituto de Investigación Sanitaria Aragón
Not yet recruiting

Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies

Conditions:   Twin Pregnancy;   Preeclampsia;   Preterm Birth;   Fetal Growth Restriction
Intervention:   Drug: Aspirin 100mg
Sponsors:   Ministry of Science and Technology of the People´s Republic of China;   The third affiliated hospital of Peking University;   Chongqing Women and Children's Health Center
Recruiting

Changes of Macular Pigment and Parameters of Eyes After YAG Laser Treatment in Cases With Capsule Opacification

Conditions:   Posterior Capsule Opacification;   Retinal Degeneration;   Retinal Detachment;   Anterior Chamber Angle Congestion;   Macula Edema;   Macular Pigmentation;   Choroid Disease
Intervention:   Device: Nd: YAG laser posterior capsulotomy
Sponsor:   Afyon Kocatepe University Hospital
Completed

Posterior Reversible Encephalopathy Syndrome in the Critically Ill Patients

Condition:   Posterior Reversible Encephalopathy Syndrome
Intervention:   Other: No intervention
Sponsors:   Ictal Group;   Versailles Hospital
Recruiting

An Open-label Extended Clinical Protocol of Ranibizumab to Evaluate Safety and Efficacy in Rare VEGF Driven Ocular Diseases.

Conditions:   Choroidal Neovascularization;   Macular Edema;   Glaucoma, Neovascular;   Diabetic Retinopathy
Intervention:   Drug: ranibizumab
Sponsor:   Novartis Pharmaceuticals
Completed