High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Natural History of Noncirrhotic Portal Hypertension

Conditions:   Cystic Fibrosis;   Immunologic Deficiency Syndrome;   Turner Syndrome;   Congenital Hepatic Fibrosis;   Idiopathic Non-Cirrhotic Portal Hypertension
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2015

Local Heat Stress in Autonomic Failure Patients With Supine Hypertension

Conditions:   Hypertension;   Pure Autonomic Failure;   Multiple System Atrophy;   Autonomic Failure
Interventions:   Other: Passive heat stress;   Other: Control (non-heating)
Sponsor:   Vanderbilt University
Recruiting - verified April 2015

SIMBRINZA® Suspension BID as an Adjunctive to Prostaglandin Analogue (PGA)

Conditions:   Open-Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Brinzolamide 1%/brimonidine 0.2% tartrate ophthalmic suspension;   Drug: Brinz/brim vehicle;   Drug: Prostaglandin analogue
Sponsor:   Alcon Research
Not yet recruiting - verified April 2015

Observational Study to Evaluate the Safety and Efficacy for Levacalm Tab. Versus Valsartan/Amlodipine Combination Therapy in Essential Hypertension Patients

Conditions:   Lower Leg Edema;   Orthostatic Hypertension
Interventions:   Drug: Levacalm;   Drug: Valsartan/amlodipine
Sponsor:   LG Life Sciences
Recruiting - verified April 2015

The Effect of a Homoeopathic Complex on Blood Pressure in Refractory Hypertension

Condition:   Essential Hypertension
Interventions:   Other: 20% ethanol;   Other: Homoeopathic complex
Sponsor:   University of Johannesburg
Recruiting - verified April 2015

Effect of Ambulatory BP Monitoring on the CliniCal coUrse and RenAl ouTcomE of CKD

Conditions:   Chronic Kidney Diseases;   Renal Insufficiency, Chronic;   Albuminuria;   Hypertension
Intervention:   Device: Ambulatory blood pressure monitoring (ABPM)
Sponsors:   Seoul National University Hospital;   Kangbuk Samsung Hospital;   Severance Hospital;   Eulji General Hospital
Not yet recruiting - verified April 2015

Post-Exercise Hypotension in Elderly Hypertensive Men

Condition:   Hypertension
Interventions:   Other: Aerobic exercise;   Other: Combined exercises;   Other: Control
Sponsors:   Hospital de Clinicas de Porto Alegre;   Federal University of Rio Grande do Sul
Recruiting - verified September 2014

Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension

Condition:   Essential Hypertension
Interventions:   Drug: Lisinopril;   Drug: Amlodipine;   Drug: Hydrochlorothiazide
Sponsor:   The University of Texas Health Science Center, Houston
Enrolling by invitation - verified April 2015

Pilot Study Testing Feasibility of Health Screening at Farm Site

Conditions:   Diabetes Screening;   Hyperlipidemia Screening;   Hypertension Screening
Intervention:   Other: Worksite screening for DM, HTN and hyperlipidemia
Sponsor:   Mayo Clinic
Recruiting - verified April 2015

Whole-exome Sequencing in Childhood Obesity

Condition:   Childhood Obesity
Intervention:  
Sponsors:   National University, Singapore;   National Medical Research Council (NMRC), Singapore;   Health Promotion Board, Singapore;   Genome Institute of Singapore A*Star, Singapore
Not yet recruiting - verified April 2015

Microalbuminuria as a Cardiovascular Risk Factor (PRECISED Substudy)

Conditions:   Microalbuminuria;   Endothelial Dysfunction;   Diabetic Nephropathy;   Diabetic Retinopathy
Intervention:   Other: non intervention
Sponsor:   Hospital Universitari Vall d'Hebron Research Institute
Not yet recruiting - verified April 2015

Fresh Start Experiment

Conditions:   Diabetes;   Hypertension
Interventions:   Behavioral: Reminder;   Behavioral: Fresh start;   Behavioral: Fresh start framing
Sponsor:   University of Pennsylvania
Recruiting - verified April 2015

Prediction of Behavior

Condition:   Diabetes, Hypertension
Interventions:   Behavioral: Prediction mailing;   Behavioral: Commitment mailing;   Behavioral: Reminder;   Behavioral: Anonymity;   Behavioral: Identification
Sponsor:   University of Pennsylvania
Recruiting - verified April 2015

Blood Pressure Control of Nifedipine GITS 60mg Treatment in Chinese Hypertensive Subjects Uncontrolled on Starting-dose Mono-therapyo-therapy

Condition:   Hypertension
Intervention:   Drug: Nifedipine(Adalat_BAY1040)
Sponsor:   Bayer
Not yet recruiting - verified April 2015

Arterial Stiffness and General Anesthesia Induced Hypotension in Patients on Angiotensin-converting Enzyme Inhibitors

Conditions:   Hypotension;   Arterial Stiffness
Intervention:   Device: SphygmoCor system
Sponsor:   University of Iowa
Recruiting - verified April 2015

Open-Labeled PK-PD Studies of Metoprolol ER

Condition:   Blood Pressure
Interventions:   Drug: Toprol XL;   Device: SmartPill Capsule;   Procedure: Exercise Treadmill;   Procedure: 24 hour holter monitor;   Other: 24-hour pharmacokinetic parameters;   Drug: Wockhardt metoprolol;   Drug: Activas metoprolol
Sponsors:   University of Florida;   Food and Drug Administration (FDA)
Not yet recruiting - verified April 2015

The Effect of Remote Ischemic Preconditioning (RIPC) on Blood Pressure and Its Vascular Protection Effect

Condition:   Pressure; Brachial Plexus
Interventions:   Procedure: RIPC;   Procedure: Sham RIPC
Sponsor:   First Affiliated Hospital, Sun Yat-Sen University
Active, not recruiting - verified April 2015

Integrated Population Program for Diabetic Kidney Disease

Conditions:   Diabetic Kidney Disease;   Uncontrolled Hypertension
Intervention:   Behavioral: Telehealth
Sponsors:   Duke University;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2015

Ketamine Infusion for Acute Sickle Cell crisiS in the Emergency Department (KISS)

Conditions:   Pain;   Sickle Cell Disorder
Interventions:   Drug: Normal saline;   Drug: Ketamine
Sponsor:   Billy Sin
Recruiting - verified April 2015

Identification of the Blood Microbiota in Patient Suffering From Myocardial Infraction

Conditions:   Coronary Disease;   Myocardial Infarction
Intervention:  
Sponsor:   University Hospital, Toulouse
Recruiting - verified April 2015

NPPV on Inflammatory Markers and Sleep in Severe Obese Patients With Metabolic Syndrome Undergone to Bariatric Surgery

Condition:   Metabolic Syndrome
Interventions:   Device: Noninvasive positive airway pressure flow generator device;   Procedure: Bariatric Surgery
Sponsor:   University of Nove de Julho
Recruiting - verified April 2015

Phase I Dose Escalation Study to Investigate the Safety of ISTH0036 in Subjects With Glaucoma Undergoing Trabeculectomy

Condition:   Primary Open Angle Glaucoma
Interventions:   Drug: TGF-β2 antisense oligonucleotide;   Procedure: Trabeculectomy
Sponsor:   Isarna Therapeutics GmbH
Recruiting - verified April 2015

aICP in Glaucoma and Papilledema

Conditions:   Open-angle Glaucoma;   Papilledema
Intervention:   Device: Non-invasive ICP measurement (Vittamed 305)
Sponsor:   Kantonsspital Aarau
Recruiting - verified April 2015

Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B

Condition:   Healthy
Interventions:   Drug: Celecoxib;   Drug: Placebo
Sponsors:   University of Pennsylvania;   Eli Lilly and Company
Recruiting - verified March 2015

Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients

Condition:   Glaucoma, Neovascular
Interventions:   Drug: Aflibercept (Eylea, BAY 86-5321);   Drug: Sham Injection
Sponsors:   Bayer;   Regeneron Pharmaceuticals
Recruiting - verified April 2015

Improving Medication Adherence Among Underserved Patients With Type 2 Diabetes

Conditions:   Type 2 Diabetes Mellitus;   Medication Adherence
Intervention:   Behavioral: Text Messaging
Sponsors:   Vanderbilt University;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting - verified April 2015

Preventing Sickle Cell Kidney Disease

Conditions:   Anemia, Sickle Cell;   Sickle Cell Disease;   Kidney Disease;   Hypertension;   Proteinuria
Interventions:   Drug: Losartan;   Drug: Losartan
Sponsors:   University of Alabama at Birmingham;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 2015

Retrospective Analysis of the Geriatric Patients Underwent Unilateral Inguinal Herniorrhaphy

Condition:   Inguinal Hernia
Intervention:   Procedure: local infiltration anesthesia and sedation
Sponsor:   Diskapi Teaching and Research Hospital
Completed - verified February 2015

Comparison of Single and Combination Diuretics in Low-Renin Hypertension

Condition:   Hypertension
Interventions:   Drug: Hydrochlorthiazide;   Drug: Amiloride;   Drug: Hydrochlorthiazide and Amiloride
Sponsors:   University of Cambridge;   University of Leicester;   University of Dundee;   University of Glasgow;   University of Edinburgh;   Imperial College London;   Barts & The London NHS Trust;   King's College London;   University of Birmingham
Active, not recruiting - verified April 2015

Stress Management for High Blood Pressure

Condition:   Prehypertension
Interventions:   Behavioral: Mindfulness-Based Stress Reduction;   Behavioral: Stress Management Education;   Other: American Heart Association Recommended Self-Care
Sponsors:   Kent State University;   University of Pennsylvania;   Case Western Reserve University
Not yet recruiting - verified April 2015

Lifestyle Interventions in Treatment-Resistant Hypertension

Condition:   Treatment-Resistant Hypertension
Interventions:   Behavioral: Structured center-based lifestyle intervention;   Behavioral: Standard education and physician advice
Sponsors:   Duke University;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified April 2015

Oxfordshire Women and Their Children's Health

Conditions:   Pregnancy;   Pre-eclampsia;   Gestational Diabetes;   Depression;   Metabolic Disorders;   Pregnancy Induced Hypertension;   Cardiovascular Disorders
Intervention:  
Sponsors:   Oxford University Hospitals NHS Trust;   University of Oxford
Recruiting - verified April 2015

Efficacy and Safety of Brinzolamide/Brimonidine Fixed Combination BID Compared to Brinzolamide BID Plus Brimonidine BID in Subjects With Open-Angle Glaucoma (OAG) or Ocular Hypertension (OHT)

Conditions:   Open-Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Brinzolamide 10 mg/mL / Brimonidine 2 mg/mL fixed combination eye drops, suspension;   Drug: Brinzolamide 10 mg/mL eye drops, suspension;   Drug: Brimonidine 2 mg/mL eye drops, solution;   Drug: Vehicle
Sponsor:   Alcon Research
Recruiting - verified April 2015

Comparative Effects of Moxonidine on Bone Metabolism, Vascular and Cellular Aging in Hypertensive Postmenopausal Women

Conditions:   Osteopenia;   Arterial Hypertension
Interventions:   Drug: Moxonidine;   Drug: Bisoprolol
Sponsor:   National Research Center for Preventive Medicine
Recruiting - verified April 2015

ReAl-life Multicentre Survey Evaluating Stroke Prevention Strategies (RAMSES)

Conditions:   Thrombotic Stroke;   Atrial Fibrillation and Flutter
Intervention:  
Sponsor:   Muğla Sıtkı Koçman University
Recruiting - verified April 2015

Weight Loss Referral for Healthier Survivorship in Obese Stage I-II Endometrial Cancer Survivors or Atypical Hyperplasia

Conditions:   Complex Endometrial Hyperplasia With Atypia;   Stage IA Uterine Corpus Cancer;   Stage IB Uterine Corpus Cancer;   Stage II Uterine Corpus Cancer
Interventions:   Behavioral: Weight Loss Specialist;   Other: Quality-of-Life Assessment;   Other: Medical Chart Review
Sponsors:   Case Comprehensive Cancer Center;   National Cancer Institute (NCI)
Recruiting - verified April 2015

Natural History and Biology of Long-Term Late Effects Following Hematopoietic Cell Transplant for Childhood Hematologic Malignancies

Conditions:   Acute Lymphoblastic Leukemia/Lymphoma;   Myelodysplasia;   Acute Myelogenous Leukemia;   Juvenile Myelomonocytic Leukemia;   Chronic Myelogenous Leukemia
Intervention:  
Sponsors:   Center for International Blood and Marrow Transplant Research;   Pediatric Blood and Marrow Transplant Consortium;   National Marrow Donor Program
Recruiting - verified April 2015

A Proof of Concept Study of Electrical Discharge Produced Nitric Oxide for Inhalation

Condition:   Hypertension, Pulmonary
Intervention:   Device: electrical pulsed plasma discharge synthesis of nitric oxide
Sponsor:   Massachusetts General Hospital
Recruiting - verified April 2015

the Canadian Health Improvement Network to Upgrade Prevention Services

Condition:   Cardiovascular Disease
Intervention:   Other: Comprehensive e-health wellness program
Sponsor:   McGill University
Enrolling by invitation - verified April 2015

An Observational Study to Describe the Effectiveness of Angiotensin Converting Enzyme Inhibitor and Calcium Channel Blocker Combination in the Management of Hypertensive Patients With Elevated Heart Rate and Type 2 Diabetes

Condition:   Hypertension
Intervention:  
Sponsors:   Abbott;   Monitor Medikal Araştırma ve Danışmanlık Tic.Ltd.Şti (MonitorCRO)
Recruiting - verified April 2015

Follow-up Study of Complications of Acute Pancreatitis

Conditions:   Pancreatitis;   Pancreatic Neoplasms;   Metabolic Diseases;   Hypertension, Portal;   Respiratory Failure;   Quality of Life
Intervention:  
Sponsor:   The First Affiliated Hospital of Nanchang University
Recruiting - verified November 2014

Effects of Ketamine in the Acute Phase of Suicidal Ideation

Condition:   Suicidal Ideation
Interventions:   Other: Baseline evaluation;   Drug: 1st perfusion of ketamine;   Drug: 1st perfusion of saline;   Other: Follow-up between perfusions;   Drug: 2nd perfusion of ketamine;   Drug: 2nd perfusion of saline;   Other: Follow-up after perfusions
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Recruiting - verified April 2015

Effect of Two Diets With Different Content of Protein on Weight Loss in Adults With Metabolic Syndrome

Conditions:   Metabolic Syndrome X;   Weight Loss
Intervention:   Other: High protein diet
Sponsor:   Mexican National Institute of Public Health
Enrolling by invitation - verified April 2015

Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone

Conditions:   Alcoholic Hepatitis;   Alcoholic Liver Disease
Interventions:   Drug: Amoxicillin;   Drug: Placebo;   Drug: Prednisolone
Sponsors:   University Hospital, Lille;   Ministry of Health, France
Not yet recruiting - verified April 2015

A Phase 4 Study of Regorafenib in Metastatic Colorectal Cancer - Does Educating Physicians Change Patient Out Comes?

Condition:   Physician Education
Intervention:   Drug: Regorafenib (Stivarga, BAY 73-4506)
Sponsor:   Bayer
Recruiting - verified April 2015

CKD-828 (80/5mg) Pharmacokinetic Study

Condition:   Hypertension
Interventions:   Drug: CKD-828;   Drug: Telmisartan;   Drug: S-amlodipine
Sponsor:   Chong Kun Dang Pharmaceutical
Completed - verified April 2015

Pediatric Pulmonary Hypertension Network (PPHNet) Informatics Registry

Conditions:   Pulmonary Vascular Disease;   Pulmonary Arterial Hypertension
Intervention:  
Sponsors:   University of Colorado, Denver;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 2015

Study on the Impact of Patient Navigators on the Health Education and Quality of Life in Formerly Incarcerated Patients

Conditions:   HIV/AIDS;   Diabetes Mellitus;   Hypertension;   Substance Use
Intervention:   Behavioral: Patient Navigation
Sponsors:   St. Luke's-Roosevelt Hospital Center;   Patient Centered Outcome Research Institute;   Hunter College of The City University of New York
Recruiting - verified April 2015

Brain fMRT In Takotsubo Cardiomyopathy

Condition:   Takotsubo Cardiomyopathy
Intervention:  
Sponsor:   Wolfgang Dichtl
Recruiting - verified April 2015

To Investigate the Effect of Tart Montmorency Cherry Juice (Prunus Cerasus) on Vascular Function.

Condition:   Hypertension
Interventions:   Dietary Supplement: 60mL tart Montmorency cherry juice;   Other: Placebo
Sponsor:   Northumbria University
Completed - verified April 2015

Reducing CVD Risk in African Americans Faith Communities

Condition:   Cardiovascular Disease Risk Factors
Intervention:   Behavioral: Education/Behavior Modification
Sponsor:   Mayo Clinic
Active, not recruiting - verified April 2015

Use of Inhaled Nitric Oxide to Prevent Pulmonary Hypertension Associated to Stored Blood Transfusion

Conditions:   Hypertension, Pulmonary;   Hemolysis
Intervention:   Drug: Nitric Oxide
Sponsor:   Massachusetts General Hospital
Not yet recruiting - verified April 2015

Nicotinamide Safety Study

Conditions:   Pregnancy Induced Hypertension;   Superimposed Preeclampsia;   Hypertension
Intervention:   Drug: Nicotinamide
Sponsor:   University of North Carolina, Chapel Hill
Recruiting - verified April 2015

AOP2014 in Patients With Polycythemia Vera Who Previously Participated in the PROUD-PV Study.

Condition:   Polycythemia Vera
Intervention:   Drug: Pegylated-Proline-interferon alpha-2b
Sponsors:   AOP Orphan Pharmaceuticals AG;   PharmaEssentia (Co-Sponsor for USA)
Recruiting - verified April 2015

A Double-masked Study of AR-13324 in Patients With Glaucoma and Ocular Hypertension

Conditions:   Ocular Hypertension;   Open-angle Glaucoma
Interventions:   Drug: AR-13324 Ophthalmic Solution, 0.02%;   Drug: Timolol maleate Ophthalmic Solution, 0.5%
Sponsor:   Aerie Pharmaceuticals
Active, not recruiting - verified April 2015

What Effect Has Case Method Education to General Practitioners on Their Knowledge on COPD and on the Health of Their Patients With COPD?

Condition:   COPD
Interventions:   Behavioral: Case method education in COPD;   Behavioral: Traditional education in COPD
Sponsors:   Karolinska Institutet;   County council Dalarna
Recruiting - verified April 2015

Intramuscular Oxytocics: A Comparison Study of Intramuscular Carbetocin, Syntocinon and Syntometrine for the Third Stage of Labour Following Vaginal Birth

Condition:   Post Partum Haemorrhage
Interventions:   Drug: Carbetocin;   Drug: Syntocinon;   Drug: Syntometrine
Sponsors:   North Bristol NHS Trust;   Ferring Pharmaceuticals;   University of Bristol;   University of the West of England;   Royal United Hospital Bath NHS Trust;   Gloucester Hospitals NHS Trust;   University Hospitals Bristol NHS Foundation Trust
Recruiting - verified August 2014

Impact of the CommunityRx Program on Health, Service Utilization and Costs

Condition:   Connecting Patients to Self-care Resources
Intervention:   Behavioral: HealtheRx
Sponsor:   University of Chicago
Recruiting - verified April 2015

Phase-II Study of the Use of PulmoBind for Molecular Imaging of Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Drug: PulmoBind
Sponsor:   Montreal Heart Institute
Recruiting - verified April 2015

Immunological Profile in Relation to Cardiac Geometry in Hypertension

Condition:   Immune System Profile During Hypertensive Cardiac Remodeling
Intervention:  
Sponsor:   Neuromed IRCCS
Recruiting - verified April 2015

Alpha-linolenic Acid and Blood Pressure

Conditions:   Hypertension;   Lipid Metabolism Disorders
Interventions:   Dietary Supplement: Flaxseed oil;   Dietary Supplement: high oleic sunflower oil (HOSF)
Sponsors:   Maastricht University Medical Center;   Unilever R&D
Recruiting - verified April 2015

Evaluation of Pulmonary Perfusion Heterogeneity in Patients With Chronic Thromboembolic Pulmonary Hypertension Using Functional PET Imaging

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Intervention:  
Sponsor:   Massachusetts General Hospital
Recruiting - verified April 2015

Pupillary Reflex Measurement to Guide Intraoperative Analgesia During Laparoscopic Surgery

Condition:   Scheduled Laparoscopic Surgery
Interventions:   Device: Pupillometry guided analgesia (PP);   Drug: Tailored remifentanil controlled infusion;   Drug: Tailored antihypertensive drug administration
Sponsor:   Central Hospital, Nancy, France
Recruiting - verified April 2015

Azilsaltan Tablets (Azilva Tablets) Special Drug Use Surveillance "Hypertension Complicated by Diabetes "

Condition:   Hypertension
Intervention:   Drug: Azilsartan
Sponsor:   Takeda
Active, not recruiting - verified April 2015

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy;   Device: Carotid stenting
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Renal Nerve Denervation in Patients With Hypertension and Paroxysmal and Persistent Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Hypertension
Interventions:   Drug: Renal nerve denervation;   Device: Cryoablation
Sponsor:   Medtronic Atrial Fibrillation Solutions
Recruiting - verified April 2015

The Effects of Obstructive Sleep Apnea and Its Intervention on Coronary Heart Disease

Conditions:   Hypertension;   Metabolic Disorder
Intervention:   Device: continuous positive airway pressure
Sponsor:   Chinese Pulmonary Vascular Disease Research Group
Completed - verified April 2015

A Cross-Sectional Survey to Evaluate Diabetes Management, Control, Complications, Psychosocial Aspects of Patients With Type 2 Diabetes in Bangladesh, Indonesia, Malaysia, Philippines, Sri Lanka and Vietnam

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Intervention:   Other: No treatment given
Sponsor:   Novo Nordisk A/S
Not yet recruiting - verified April 2015

Monotherapy-Controlled Study of Nifedipine Gastrointestinal Therapeutic System and Candesartan Cilexetil in Combination in Subjects With Essential Hypertension Inadequately Controlled on Candesartan Cilexetil

Condition:   Hypertension
Interventions:   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106);   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106);   Drug: Candesartan Cilexetil;   Drug: Candesartan matching placebo;   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106) 30/16mg matching placebo;   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106)
Sponsor:   Bayer
Not yet recruiting - verified April 2015

Open-label, Multi-center Protocol to Provide QTI571 to PAH Patients Who Participated in the Extension Study (A2301E1) in Japan

Condition:   Severe Pulmonary Arterial Hypertension
Intervention:   Drug: QTI571
Sponsor:   Novartis Pharmaceuticals
Active, not recruiting - verified April 2015

Bardoxolone Methyl Evaluation in Patients With Pulmonary Arterial Hypertension (PAH) - LARIAT

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Bardoxolone methyl;   Drug: Placebo
Sponsor:   Reata Pharmaceuticals, Inc.
Recruiting - verified April 2015

Impact of Consumption of Beta-glucans on the Intestinal Microbiota and Glucose and Lipid Metabolism

Conditions:   Metabolic Syndrome;   Dyslipidemia;   Obesity, Abdominal;   Hyperglycemia;   Hypertension
Interventions:   Dietary Supplement: Bread with added beta-glucans;   Dietary Supplement: Placebo Comparator: Bread without added beta-glucans
Sponsors:   Mlinotest Zivilska Industrija d.d.;   University of Ljubljana;   University Medical Centre Ljubljana
Enrolling by invitation - verified April 2015

Comparative PK PD Study in PAH Patients (Fox vs. I-Neb)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: lloprost(Ventavis,BAYQ6252, 20 µg/mL);   Drug: lloprost(Ventavis,BAYQ6252, 10 µg/mL)
Sponsor:   Bayer
Active, not recruiting - verified April 2015

MERIT-2: Macitentan in thE tReatment of Inoperable Chronic Thromboembolic Pulmonary Hypertension (OL)

Condition:   Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Recruiting - verified April 2015

Blood-brain Barrier Quantification in Cerebral Small Vessel Disease

Conditions:   Blood-Brain Barrier Permeability;   Cerebral Small Vessel Disease;   Cerebral Hemorrhage;   Cortical Stroke
Intervention:   Procedure: Dynamic contrast enhanced Brain MRI
Sponsor:   Maastricht University Medical Center
Recruiting - verified April 2015

Comparison of Latanoprost PPDS With Timolol Maleate GFS in Subjects With Ocular Hypertension or Open-Angle Glaucoma

Conditions:   Ocular Hypertension;   Open-Angle Glaucoma
Interventions:   Drug: Latanoprost Punctal Plug Delivery System (L-PPDS);   Drug: Timolol Maleate GFS, 0.5%
Sponsor:   Mati Therapeutics Inc.
Recruiting - verified September 2014

Riociguat Clinical Effects Studied in Patients With Insufficient Treatment Response to Phosphodiesterase-5 Inhibitor

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsor:   Bayer
Recruiting - verified April 2015

A Study of GANFORT® UD in Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT) in a Medical Setting

Conditions:   Glaucoma, Primary Open Angle;   Ocular Hypertension
Intervention:   Drug: Fixed Combination Bimatoprost and Timolol
Sponsor:   Allergan
Completed - verified April 2015

Non-invasive Haemodynamic Assessment in Hypertension

Condition:   Arterial Hypertension
Interventions:   Drug: lisinopril;   Drug: Telmisartan;   Drug: Nebivolol;   Drug: Indapamide/hydrochlorothiazide;   Drug: Amlodipine;   Drug: lisinopril;   Drug: Telmisartan;   Drug: Nebivolol;   Drug: Indapamide/hydrochlorothiazide;   Drug: Amlodipine
Sponsor:   Military Institute of Medicine, Poland
Recruiting - verified April 2015

Early Detection of Progressive Kidney Disease in Preterm Infants

Condition:   Kidney Disease
Intervention:  
Sponsor:   University of Miami
Active, not recruiting - verified April 2015

Effect and Safety of Marealis RPC (Refined Peptide Concentrate) in Mild or Moderate Hypertensive Subjects

Condition:   Prehypertension
Interventions:   Dietary Supplement: Marealis refined peptide concentrate;   Dietary Supplement: Placebo
Sponsors:   KGK Synergize Inc.;   Marealis AS
Recruiting - verified April 2015

Confirmatory Study of IK-3001 in Japanese Subjects With Peri-/Post-op Pulmonary Hypertension Assoc. With Cardiac Surgery

Conditions:   Hypertension, Pulmonary;   Ventricular Dysfunction, Left
Intervention:   Drug: IK-3001
Sponsor:   INO Therapeutics
Completed - verified April 2015

Non-interventional Study on Compliance of Inhaled Treatment With Ventavis in Patient With Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Iloprost (Ventavis, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified April 2015

Evaluation of Blood Pressure Reduction, Safety, and Tolerability of Canagliflozin in Patients With Hypertension and Type 2 Diabetes Mellitus on Stable Doses of Anti-hyperglycemic and Anti-hypertensive Agents

Conditions:   Diabetes Mellitus, Type 2;   Hypertension
Interventions:   Drug: Canagliflozin;   Drug: Placebo
Sponsor:   Janssen Scientific Affairs, LLC
Completed - verified April 2015

GLORIA-AF Registry Program (Phase II/III)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

Aliskiren Study of Safety and Efficacy in Senior Hypertensives

Condition:   Hypertension
Interventions:   Drug: Aliskiren;   Drug: Amlodipine;   Drug: Ramipril;   Drug: Hydrochlorothiazide
Sponsor:   Novartis Pharmaceuticals
Withdrawn - verified April 2015

Effects of Caloric Restriction in Obesity and Type 2 Diabetes

Conditions:   Type 2 Diabetes;   Obesity
Interventions:   Behavioral: Calorie restriction (25%);   Behavioral: Ad libitum health diet
Sponsors:   Mario Negri Institute for Pharmacological Research;   Istituto Superiore di Sanità
Recruiting - verified April 2015

Beraprost-314d Added-on to Tyvaso® (BEAT)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Beraprost Sodium 314d Modified Release Tablets;   Drug: Placebo
Sponsor:   Lung Biotechnology PBC
Recruiting - verified April 2015

Effect of Antihypertensive Agents Over Sleep Apnea

Conditions:   Hypertension;   Obstructive Sleep Apnea
Interventions:   Drug: Diuretics;   Drug: Calcium Channel Blockers
Sponsor:   Hospital de Clinicas de Porto Alegre
Recruiting - verified April 2015

Sildenafil Therapy For Subjects Who Derive Clinical Benefit From Continued Treatment With Sildenafil

Condition:   Pulmonary Arterial Hypertension (PAH)
Intervention:   Drug: sildenafil
Sponsor:   Pfizer
Available - verified April 2015

ACE Inhibitors Combined With Exercise for Seniors - Pilot Study

Conditions:   Hypertension;   Aging
Interventions:   Behavioral: Exercise;   Drug: ACE inhibitor + exercise;   Drug: Thiazide diuretic + exercise;   Drug: Angiotensin receptor blocker + exercise
Sponsors:   University of Florida;   American Heart Association
Recruiting - verified April 2015

An Efficacy and Safety Study of Bimatoprost 0.01% Alone Compared With Travoprost 0.004% and Timolol 0.5% in Subjects With Glaucoma or Ocular Hypertension

Conditions:   Glaucoma;   Ocular Hypertension
Interventions:   Drug: bimatoprost 0.01%;   Drug: travatan 0.004%;   Drug: timolol 0.5%;   Drug: hypromellose 0.3%
Sponsor:   Allergan
Completed - verified April 2015

Abiraterone With Different Steroid Regimens for Side Effect Related to Mineralcorticoid Excess Prevention in Prostate Cancer Prior to Chemotherapy

Condition:   Prostate Cancer
Interventions:   Drug: Abiraterone Acetate;   Drug: Prednisone 5 mg twice daily;   Drug: Prednisone 5 mg once daily;   Drug: Prednisone 2.5 mg twice daily;   Drug: Dexamethasone 0.5 mg once daily
Sponsor:   Janssen Pharmaceutica N.V., Belgium
Recruiting - verified April 2015

The Use of Near Infrared Spectroscopy (NIRS) to Estimate Intracranial Pressure (ICP)

Condition:   Intracranial Hypertension
Intervention:  
Sponsor:   University of Virginia
Recruiting - verified April 2015

SYMPHONY: A Study of Macitentan in Pulmonary Arterial Hypertension to Validate the PAH-SYMPACT

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Recruiting - verified April 2015

Prognostic Value of Aβ Imaging in NPH Prior to Shunt Placement

Condition:   Normal Pressure Hydrocephalus Patients
Intervention:   Procedure: Shunt surgery
Sponsor:   Mayo Clinic
Recruiting - verified April 2015

Risk Factors for Drusen Progression

Condition:   Age-related Macular Degeneration
Intervention:  
Sponsor:   Medical University of Vienna
Withdrawn - verified April 2015

Proton w/FOLFIRINOX-Losartan for Pancreatic Cancer

Condition:   Pancreatic Cancer
Interventions:   Drug: FOLFIRINOX;   Drug: Losartan;   Radiation: Proton Beam Radiation
Sponsors:   Massachusetts General Hospital;   National Cancer Institute (NCI)
Recruiting - verified April 2015

Relation of Consummatory and Anticipatory Food Reward to Obesity

Conditions:   Weight Gain;   Food Habits
Intervention:  
Sponsors:   Oregon Research Institute;   National Institutes of Health (NIH)
Active, not recruiting - verified April 2015

Retinal Vessel Measurements as Clinically Useful Predictors in Veterans

Condition:   Diabetes
Intervention:  
Sponsor:   Department of Veterans Affairs
Recruiting - verified April 2015

Multicentric Observational Study on Quality of Life in Glaucoma

Condition:   Primary Open-angle Glaucoma
Intervention:  
Sponsor:   Mario Negri Institute for Pharmacological Research
Completed - verified April 2015

Non-contrast Enhanced Cardiac Magnetic Resonance Imaging in the Diagnosis and Classification of Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Elevated Mean Pulmonary Arterial Pressure;   Normal Mean Pulmonary Arterial Pressure
Intervention:   Other: Cardiac MRI
Sponsor:   Medical University of Graz
Enrolling by invitation - verified April 2015

Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers

Conditions:   Pre-eclampsia;   Intra-uterine Growth Restriction
Interventions:   Drug: Aspirin;   Drug: Placebo
Sponsor:   University Hospital, Tours
Recruiting - verified April 2015

Feasibility Study to Evaluate Renal Denervation Using Focused Ultrasound

Condition:   Hypertension
Intervention:   Device: Kona Externally Focused Ultrasound Therapy
Sponsor:   Kona Medical Inc.
Completed - verified April 2015

Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics

Condition:   Hypertension
Intervention:   Other: Sevoflurane/oxygen/air/nitrous oxide
Sponsors:   Lawson Health Research Institute;   University of Western Ontario, Canada
Recruiting - verified April 2015

Study of the Safety and Efficacy of LCZ696 on Arterial Stiffness in Elderly Patients With Hypertension

Condition:   Hypertension
Interventions:   Drug: LCZ696;   Drug: Olmesartan;   Drug: LCZ696 matching placebo;   Drug: Olmesartan matching placebo;   Drug: amlodipine;   Drug: hydrochlorothiazide
Sponsor:   Novartis Pharmaceuticals
Active, not recruiting - verified April 2015

A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn

Condition:   Pulmonary Hypertension, Familial Persistent, of the Newborn
Interventions:   Drug: placebo;   Drug: iv sildenafil
Sponsor:   Pfizer
Recruiting - verified April 2015

Plasma and Hemodynamic Markers During Hepatectomy

Condition:   Hepatorenal Syndrome, Liver Regeneration
Intervention:   Procedure: Liver resection
Sponsor:   Medical University of Vienna
Completed - verified April 2015

Multi-electrode Radiofrequency Renal Denervation System Feasibility Study

Condition:   Uncontrolled Hypertension
Intervention:   Device: Medtronic Multi-electrode Radiofrequency (RF) Renal Denervation system
Sponsor:   Medtronic Vascular
Active, not recruiting - verified April 2015

Helping Hypertensive Latinos to Improve Medication Adherence

Condition:   Hypertension
Intervention:   Behavioral: Adherence Intervention
Sponsors:   New York University School of Medicine;   American Heart Association
Recruiting - verified April 2015

A Safety Evaluation of Renal Denervation Using Focused Therapeutic Ultrasound on Patients With Refractory Hypertension

Condition:   Hypertension
Intervention:   Device: Focused Ultrasound
Sponsor:   Kona Medical Inc.
Completed - verified April 2015

Single-arm Study of Symplicity™ Renal Denervation System in Patients With Uncontrolled HyperTensioN in India

Condition:   Adults With Uncontrolled Hypertension
Intervention:   Device: Symplicity renal denervation system
Sponsors:   Medtronic Vascular;   Medtronic
Terminated - verified April 2015

Prevention Trial to Achieve Cardiovascular Targets

Conditions:   Coronary Artery Disease;   Peripheral Arterial Disease;   Hyperlipidemia;   Hypertension;   Diabetes;   Prediabetes;   Obesity
Interventions:   Behavioral: Prevention Consult;   Behavioral: Consult & Behavioral Intervention
Sponsors:   New York University School of Medicine;   The Rainer Arnhold Foundation
Recruiting - verified April 2015

Safety And Efficacy Of Sildenafil In Children With Pulmonary Arterial Hypertension

Conditions:   Pulmonary Arterial Hypertension;   Hypertension, Pulmonary
Intervention:   Drug: Sildenafil
Sponsor:   Pfizer
Recruiting - verified April 2015

Efficacy, Safety and Tolerability of Multiple Doses of Valsartan in Children With Hypertension With or Without CKD

Condition:   Pediatric Hypertension With or Without CKD
Interventions:   Drug: VAL489;   Drug: VAL489 matching placebo
Sponsor:   Novartis Pharmaceuticals
Recruiting - verified April 2015

Randomized, Double-Blind, Safety and Efficacy Study of RE-021 (Sparsentan) in Focal Segmental Glomerulosclerosis

Condition:   Focal Segmental Glomerulosclerosis
Interventions:   Drug: RE-021 (Sparsentan);   Drug: Irbesartan
Sponsor:   Retrophin, Inc.
Recruiting - verified April 2015

An Open Label Access Study For Subjects Who Completed A1481156

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Access program
Sponsor:   Pfizer
Temporarily not available - verified April 2015

Factors Influencing the Positive Outcome of Bariatric Surgery for Morbidly Obese Patients

Conditions:   Morbid Obesity;   Diabetes;   Hypertension
Intervention:  
Sponsor:   Assuta Hospital Systems
Recruiting - verified March 2012

Electromagnetic Field Therapy to Improve Healing of Chronically Venous Ulcer

Conditions:   Chronic Venous Hypertension With Ulcer and Inflammation;   Venous Ulcer Pain
Interventions:   Device: Active Pulsed Electro-Magnetic Field (PEMF);   Device: Placebo Pulsed Electro-Magnetic Field (PEMF)
Sponsor:   Northern Orthopaedic Division, Denmark
Active, not recruiting - verified April 2015

Preeclampsia: A Marker for Future Cardiovascular Risk in Women

Conditions:   Preeclampsia;   Pregnancy Induced Hypertension
Intervention:   Drug: Irbesartan
Sponsor:   Brigham and Women's Hospital
Recruiting - verified April 2015

Effect of Renin-angiotensin System Blockers on Glomerular Filtration Rate in Patients With Hypertension, Type 2 Diabetes With Normoalbuminuria

Conditions:   Diabetes;   Hypertensive Disease
Interventions:   Drug: Renin-angiotensin system blockers;   Drug: non-renin angiotensin system blockers
Sponsor:   Hospital Authority, Hong Kong
Recruiting - verified April 2015

Impact of a Multidisciplinary Intensive Management Clinic on Outcomes in Multi-Ethnic Asian Incident Hemodialysis Patients

Condition:   Stage 5 Chronic Kidney Disease
Intervention:   Other: Multidisciplinary, intensive and collaborative care
Sponsor:   National University, Singapore
Recruiting - verified April 2015

Integrated Diagnostics Characterization of Right Ventricular Diastolic Flow Dynamics in Pulmonary Arterial Hypertension

Condition:   Pulmonary Hypertension
Intervention:  
Sponsors:   National Jewish Health;   Siemens Medical Solutions
Completed - verified April 2015

Cardiac Energetics and Function in Normal Human Ageing

Conditions:   Left Ventricular Function Systolic Dysfunction;   Left Ventricular Function Diastolic Dysfunction;   Ageing
Intervention:   Drug: Ramipril
Sponsor:   Newcastle-upon-Tyne Hospitals NHS Trust
Enrolling by invitation - verified April 2015

Step Monitoring to Improve ARTERial Health

Conditions:   Type 2 Diabetes;   Hypertension
Interventions:   Behavioral: Step count prescription;   Behavioral: Usual care
Sponsors:   McGill University Health Center;   Canadian Institutes of Health Research  (CIHR)
Active, not recruiting - verified April 2015

Epoprostenol for Injection in Patients With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Epoprostenol
Sponsor:   Actelion
Active, not recruiting - verified April 2015

Evaluation of Pulmonary Perfusion Heterogeneity and Compliance in Patients With Pulmonary Hypertension Using Positron Emission Tomography Imaging

Condition:   Pulmonary Arterial Hypertension
Intervention:   Other: CT imaging, functional PET imaging
Sponsor:   Massachusetts General Hospital
Recruiting - verified April 2015

Pilot Study of Home Blood Pressure Control Program

Conditions:   Hypertension;   Cardiovascular Disease
Intervention:   Behavioral: HBPM+website+patient navigator
Sponsors:   Memorial Hospital of Rhode Island;   Agency for Healthcare Research and Quality (AHRQ)
Completed - verified April 2015

Safety and Tolerability of Valsartan in Children 6 to 17 Years of Age

Conditions:   Hypertension;   Chronic Kidney Disease
Intervention:   Drug: Valsartan
Sponsor:   Novartis Pharmaceuticals
Active, not recruiting - verified April 2015

DE-111 Against Tafluprost Ophthalmic Solution 0.0015% Alone and Concomitant Use of Tafluprost Ophthalmic Solution 0.0015% Plus Timolol Ophthalmic Solution 0.5%

Conditions:   Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: DE-111 ophthalmic solution;   Drug: Tafluprost ophthalmic solution 0.0015%;   Drug: Concomitant use of tafluprost ophthalmic solution 0.0015% plus timolol ophthalmic solution 0.5%
Sponsor:   Santen Pharmaceutical Co., Ltd.
Completed - verified July 2012

DE-111 Ophthalmic Solution in Patients With Open Angle Glaucoma or Ocular Hypertension

Condition:   Open Angle Glaucoma or Ocular Hypertension
Intervention:   Drug: DE-111 ophthalmic solution
Sponsor:   Santen Pharmaceutical Co., Ltd.
Completed - verified February 2013

DE-111 Against Timolol Ophthalmic Solution 0.5%

Conditions:   Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: DE-111 ophthalmic solution;   Drug: Timolol ophthalmic solution 0.5%
Sponsor:   Santen Pharmaceutical Co., Ltd.
Completed - verified July 2012

Consumption of Chocolate in Pregnant Women.

Condition:   Preeclampsia
Interventions:   Other: Flavanol-rich chocolate;   Other: Placebo Chocolate
Sponsor:   Laval University
Completed - verified April 2015

ShuntCheck Versus Radionuclide in Evaluating Shunt Function in Symptomatic NPH Patients

Condition:   Hydrocephalus
Intervention:   Device: ShuntCheck test
Sponsors:   NeuroDx Development;   Sinai Hospital of Baltimore;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Youth Lifestyle Intervention With Food and Exercise

Conditions:   Healthy;   Obesity
Interventions:   Behavioral: 2 servings dairy + exercise;   Behavioral: 4 servings dairy + exercise;   Behavioral: Control
Sponsors:   McGill University;   Dairy Farmers of Canada
Completed - verified April 2015

RCT of Effects of Device-guided Breathing on Ambulatory BP

Condition:   Hypertension
Interventions:   Behavioral: Device-guided breathing;   Behavioral: Device-guided breathing - used for 16 weeks;   Behavioral: Relaxation;   Device: RESPeRate;   Device: Sham RESPeRate
Sponsors:   Rutgers, The State University of New Jersey;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2015

Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)

Condition:   Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Interventions:   Biological: Rituximab;   Other: Placebo
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified April 2015

Non Invasive Study of the Hepatic Fibrosis in Paediatrics by the Method of Study of Pediatric Hepatic Fibrosis

Conditions:   Cirrhosis;   Liver Fibrosis;   Portal Hypertension;   Cystic Fibrosis;   Cholestasis of Parenteral Nutrition
Intervention:   Other: Elastometry
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting - verified April 2015

Cozaar XQ Re-examination Study (MK-0954-349)

Condition:   Hypertension
Intervention:   Drug: amlodipine/losartan
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified April 2015

The PREVENTS Trial: The Preventing Recurrent Events in Veterans Navigating Transient Ischemic Attack (TIA) or Stroke Trial

Conditions:   Stroke;   Transient Ischemic Attack
Interventions:   Behavioral: tailored intervention;   Behavioral: attention placebo
Sponsor:   Narrows Institute for Biomedical Research
Completed - verified April 2015

Double Blind Placebo Study of JARDIANCE® (Empagliflozin) in Prehypertensives Type II Diabetics

Conditions:   Hypertension;   Type II Diabetes
Interventions:   Drug: empagliflozin;   Drug: Metformin
Sponsor:   Aristotle University Of Thessaloniki
Not yet recruiting - verified April 2015

Angiotensin-converting-enzyme (ACE) Inhibitors in Hemodialysis

Conditions:   Left Ventricular Hypertrophy;   Hypertension
Interventions:   Drug: ACE inhibitor Ramipril;   Drug: non-RAS inhibitor antihypertensive therapy
Sponsors:   Mario Negri Institute for Pharmacological Research;   Agenzia Italiana del Farmaco
Active, not recruiting - verified April 2015

Impact of an Integrated Obesity Management System on Patient's Care

Condition:   Obesity
Intervention:   Behavioral: 2-day preceptorship on obesity management
Sponsors:   Université de Sherbrooke ;   Canadian Institutes of Health Research  (CIHR)
Active, not recruiting - verified April 2015

Clinical Trial on the Effects of Long Term Administration of 20% Albumin in the Cardiovascular and Renal Function, And Hepatic Hemodynamics in Advanced Patients With Cirrhosis and Ascites.

Conditions:   Cirrhosis;   Ascites
Intervention:   Drug: Albumin
Sponsors:   Joan Albert Arnaiz;   Hospital Clinic of Barcelona
Completed - verified April 2015

Nutrition and Exercise Intervention Study

Conditions:   Hypertension;   Dyslipidemia;   Diabetes;   Low Back Pain
Intervention:   Behavioral: physical activity
Sponsor:   National Institute of Health and Nutrition
Active, not recruiting - verified April 2015

Ventavis® Registry Protocol

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Commercial Ventavis® (iloprost)
Sponsor:   Actelion
Terminated - verified April 2015

Open Label Access Study Of Sildenafil In Adult Patients With Pulmonary Arterial Hypertension Completing A1481244 Study

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Sildenafil citrate
Sponsor:   Pfizer
Temporarily not available - verified April 2015

International Registry for Primary Hyperoxaluria

Conditions:   Primary Hyperoxaluria;   Nephrocalcinosis;   Kidney Stones
Intervention:  
Sponsors:   Mayo Clinic;   National Institutes of Health (NIH);   Oxalosis and Hyperoxaluria Foundation (OHF)
Withdrawn - verified April 2015

SCOT Scleroderma Treatment Alternative Registry (STAR Registry)

Conditions:   Scleroderma, Systemic;   Sclerosis
Intervention:   Drug: currently available therapy in the community
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Active, not recruiting - verified April 2015

Association of Periodontitis and Preeclampsia During Pregnancy

Conditions:   Preeclampsia;   Periodontal Disease
Intervention:  
Sponsors:   Maulana Azad Medical College;   University Grants Commission, New Delhi
Completed - verified April 2015

Hispanics With Metabolic Syndrome and Non-ischemic Heart Failure

Conditions:   Metabolic Syndrome;   Heart Failure
Intervention:  
Sponsors:   Texas Tech University Health Sciences Center;   Health Resources and Services Administration (HRSA)
Withdrawn - verified April 2015

Evidence Synthesis: Hypertension Medication Adherence & Intensification

Condition:   Hypertension
Intervention:  
Sponsor:   Department of Veterans Affairs
Completed - verified July 2014

PTFE Covered Stents Versus Naked Stents in the TIPS (Transjugular Intra-hepatic Porto-systemic Shunt)

Condition:   Cirrhotic Portal Hypertension
Interventions:   Device: Naked Stents: Wallstent® (Boston Scientific), Luminexx® (Bard), Zilver® (Cook), Palmaz Genesis® and Smart Control® (Cordis);   Device: PTFE Covered Stents: Fluency® (Bard), Advanta V12® (Atrium) and Viatorr® (Gore);   Procedure: Transjugular intrahepatic portosystemic shunt (TIPS)
Sponsor:   University Hospital, Tours
Completed - verified April 2015

Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC)

Conditions:   Liver Diseases;   Alagille Syndrome;   Alpha 1-Antitrypsin Deficiency
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified April 2015

Long Term Treatment of End Stage Renal Disease Patients With Lanthanum Carbonate (Fosrenol)

Condition:   Hyperphosphatemia
Intervention:  
Sponsor:   Shire
Active, not recruiting - verified April 2014

A Study to Evaluate the Effectiveness of Cosopt® as First Line Therapy (MK-0507A-153)

Conditions:   Glaucoma;   Ocular Hypertension
Interventions:   Drug: dorzolamide hydrochloride (+) timolol maleate;   Drug: Comparator: dorzolamide HCl/timolol maleate + prostaglandin
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified April 2015

Bevacizumab Versus Ranibizumab for Diabetic Retinopathy

Conditions:   Diabetic Retinopathy;   Diabetic Macular Edema;   Proliferative Diabetic Retinopathy
Interventions:   Drug: bevacizumab;   Drug: Ranibizumab
Sponsor:   Ursula Schmidt-Erfurth, M.D.
Completed - verified April 2015

P-glycoprotein Inhibition as Adjunct Treatment for Medically Refractory Epilepsy.

Condition:   Epilepsy
Intervention:   Drug: Carvedilol-CR
Sponsors:   Columbia University;   American Epilepsy Society;   Milken Family Foundation;   GlaxoSmithKline
Terminated - verified April 2015

Preventing Microalbuminuria in Type 2 Diabetes

Condition:   Diabetes
Interventions:   Drug: Benazepril;   Drug: Valsartan;   Drug: Benazepril/Valsartan
Sponsors:   Mario Negri Institute for Pharmacological Research;   Agenzia Italiana del Farmaco
Active, not recruiting - verified April 2015

Community Based Multiple Risk Factors Intervention Strategy

Conditions:   Hypertension;   Diabetes Mellitus;   Hyperlipidemia
Interventions:   Behavioral: No Active Intervention.;   Behavioral: Community Based Multiple Risk Factor Intervention Strategies
Sponsor:   Ministry of Health, Malaysia
Completed - verified April 2010

Efficacy of Perindopril to Prevent Recurrence of Atrial Fibrillation in Patients With Essential Hypertension

Conditions:   Essential Hypertension;   Atrial Fibrillation
Intervention:   Drug: Perindopril
Sponsors:   Montreal Heart Institute;   Servier
Active, not recruiting - verified April 2015

Ambient Air Pollution, Preeclampsia, and Preterm Delivery

Conditions:   Preeclampsia;   Preterm Delivery
Intervention:  
Sponsor:   National Institute of Environmental Health Sciences (NIEHS)
Completed - verified April 2015

Veteran Preference For Group Visits and Its Effect on Hypertension Outcomes

Conditions:   Hypertension;   Blood Pressure
Intervention:   Behavioral: Group Visits
Sponsor:   Department of Veterans Affairs
Completed - verified November 2007

Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen

Condition:   Arthritis, Rheumatoid
Interventions:   Drug: celecoxib;   Drug: Ibuprofen;   Drug: Naproxen
Sponsors:   Pfizer;   The Cleveland Clinic
Active, not recruiting - verified April 2015

A Behavioral Intervention To Improve Hypertension Control In Veterans

Condition:   Hypertension
Interventions:   Behavioral: SMI;   Behavioral: HEI;   Behavioral: UC;   Behavioral: SMI;   Behavioral: HEI;   Behavioral: UC
Sponsor:   Department of Veterans Affairs
Completed - verified April 2015

Improving Practice Patterns for the Treatment of Hypertension

Condition:   Hypertension
Interventions:   Behavioral: Provider Education;   Behavioral: Hypertension Alert;   Behavioral: Patient Education
Sponsor:   Department of Veterans Affairs
Completed - verified May 2006

Left Ventricular and Endothelial Function in Preeclampsia

Condition:   Preeclampsia
Intervention:  
Sponsors:   Norwegian University of Science and Technology;   Central Norway Regional Health Authority
Completed - verified April 2015

Group Visits to Improve Hypertension Management

Condition:   Hypertension
Intervention:   Behavioral: Group medical visits
Sponsor:   Department of Veterans Affairs
Completed - verified May 2009

Guidelines for Drug Therapy of Hypertension: Multi-Site Implementation

Condition:   Hypertension
Interventions:   Behavioral: ATHENA Decision Support System, An Automated Clinical Decision Support System for Health Care Providers;   Behavioral: Profiling performance
Sponsor:   Department of Veterans Affairs
Completed - verified October 2007

Effectiveness of Home-Based Health Messaging for Patients With Hypertension and Diabetes

Conditions:   Diabetes Mellitus;   Hypertension
Intervention:   Behavioral: In Home Health Messaging Device
Sponsor:   Department of Veterans Affairs
Completed - verified January 2008

Scleroderma: Cyclophosphamide or Transplantation (SCOT)

Conditions:   Scleroderma, Systemic;   Sclerosis;   Autoimmune Disease
Interventions:   Procedure: Autologous stem cell transplantation;   Drug: Cyclophosphamide;   Drug: Antithymocyte globulin, equine;   Drug: Methylprednisolone;   Drug: Growth colony stimulating factor (G-CSF);   Radiation: Total body irradiation (TBI)
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Active, not recruiting - verified April 2015

Study to Lower Veterans BP: Patient/Physician Intervention

Condition:   Hypertension
Interventions:   Behavioral: Telephone behavioral education;   Behavioral: Computer behavioral education
Sponsor:   Department of Veterans Affairs
Completed - verified April 2006

Internet-based Diabetes Education and Case Management

Conditions:   Diabetes Mellitus;   Hypertension
Interventions:   Procedure: Web-based care management;   Procedure: Telephone and face-to-face care management;   Procedure: Internet access alone
Sponsor:   Department of Veterans Affairs
Completed - verified August 2010

Effect Of Carvedilol Versus Metoprolol On Glycemic Control In Patients With Type II Diabetes And Hypertension

Condition:   Hypertension
Interventions:   Drug: carvedilol;   Drug: metoprolol
Sponsor:   GlaxoSmithKline
Completed - verified April 2015

Glycemic Control Of Carvedilol Versus Metoprolol In Patients With Type II Diabetes Mellitus And Hypertension

Condition:   Hypertension
Interventions:   Drug: carvedilol;   Drug: metoprolol
Sponsor:   GlaxoSmithKline
Completed - verified June 2012

Guidelines for Drug Therapy of Hypertension: Closing the Loop

Condition:   Hypertension
Intervention:   Procedure: Computer generated statements about guideline concordance of drug therapy deliver to clinicians
Sponsors:   Department of Veterans Affairs;   Stanford University
Completed - verified February 2007

Improving Service Delivery Through Access Points

Conditions:   Hypertension;   Angina;   Diabetes
Intervention:  
Sponsor:   Department of Veterans Affairs
Completed - verified April 2015

Effectiveness and Cost Impact of a Telecommunications System in COPD

Condition:   Lung Diseases, Obstructive
Intervention:   Procedure: Telephone Monitoring
Sponsor:   Department of Veterans Affairs
Completed - verified February 2007

Dietary Intervention Study for Hypertension (DISH)

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Hypertension;   Vascular Diseases
Interventions:   Behavioral: diet, sodium-restricted;   Behavioral: diet, reducing
Sponsors:   University of Mississippi Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2000

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