High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Changes in Renal Function and Body Composition in Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Renal Function Abnormal
Intervention:   Diagnostic Test: No intervention
Sponsor:   University of Giessen
Completed

Gastrodia and Uncaria Recipe in Treating Stage-one Hypertension: an Evidence-based Optimization Study

Condition:   Hypertension
Interventions:   Drug: Gastrodia and Uncaria granule;   Drug: Placebo of Gastrodia and Uncaria granule
Sponsors:   Shanghai Institute of Hypertension;   Shanghai Ruijin Hospital North, Shanghai Jiaotong University School of Medicine;   Shanghai General Hospital, Shanghai Jiaotong University School of Medicine
Recruiting

Inhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension

Conditions:   Sarcoidosis;   Precapillary Pulmonary Hypertension;   Interstitial Lung Disease
Intervention:   Drug: Inhaled Treprostinil
Sponsors:   University of Florida;   United Therapeutics
Not yet recruiting

Assessing Portal Hypertension With Methacetin Breath Test

Condition:   Patients With Compensated Liver Cirrhosis
Intervention:   Device: Methacetin Breath Test
Sponsor:   Exalenz Bioscience LTD.
Completed

Assessment of Portal Hypertension With Multiparametric MRI

Conditions:   Portal Hypertension;   Clinically Significant Portal Hypertension
Interventions:   Procedure: mpMRI;   Procedure: ARFI US
Sponsors:   Icahn School of Medicine at Mount Sinai;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension

Conditions:   Sickle Cell Anemia;   Pulmonary Hypertension
Interventions:   Drug: Nitric Oxide;   Device: INO Pulse - NO Delivery System
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   Mallinckrodt
Completed

Riociguat in Children With Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsors:   Bayer;   Merck Sharp & Dohme Corp.
Recruiting

A New Breath for Malignant Hypertension: Implementation of the HAMA Cohort

Condition:   Malignant Hypertension
Intervention:  
Sponsor:   Centre Hospitalier de PAU
Recruiting

The Use of TRIple Fixed-dose COmbination in the Treatment of arteriaL Hypertension: Opportunity for Effective BP Control With cOmbined Antihypertensive theRapy

Condition:   Arterial Hypertension
Intervention:   Drug: amlodipine / indapamide / perindopril arginine FDC
Sponsor:   Servier Russia
Recruiting

Neolifes Heart - Pulmonary Hypertension in Preterm Children

Conditions:   Pulmonary Hypertension;   Bronchopulmonary Dysplasia
Intervention:  
Sponsor:   University Medical Center Groningen
Recruiting

Mechanism of Masked Hypertension - Intervention

Condition:   Masked Hypertension
Interventions:   Drug: Carvedilol;   Drug: Amlodipine
Sponsor:   University of Alabama at Birmingham
Not yet recruiting

Pulmonary Vascular Disease Phenomics Program PVDOMICS

Condition:   Pulmonary Arterial Hypertension
Intervention:   Other: No Intervention
Sponsors:   The Cleveland Clinic;   Brigham and Women's Hospital;   Columbia University;   Weill Medical College of Cornell University;   Johns Hopkins University;   Mayo Clinic;   University of Arizona;   Vanderbilt University
Recruiting

BREMEN Eye Drops Versus Combigan for Open-angle Glaucoma or Intraocular Hypertension

Conditions:   Ocular Hypertension;   Primary Open-angle Glaucoma
Interventions:   Drug: BREMEN eye drops;   Drug: Combigan®
Sponsor:   EMS
Not yet recruiting

Prospective, Non-interventional, Multi-center, Post-authorization Safety Study of Riociguat for Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Recruiting

Long-term Study of CS-3150 as Monotherapy or in Combination With Other Antihypertensive Drug in Japanese Patients With Essential Hypertension

Condition:   Essential Hypertension
Intervention:   Drug: CS-3150
Sponsor:   Daiichi Sankyo Co., Ltd.
Completed

Identifying Most Effective Treatment Strategies to Control Arterial Hypertension in Sub-Saharan Africa

Condition:   Arterial Hypertension
Interventions:   Other: dual combination;   Other: triple combination;   Other: Standard of care
Sponsors:   University Hospital, Basel, Switzerland;   Swiss National Fund for Scientific Research
Not yet recruiting

Reducing Right Ventricular Failure in Pulmonary Arterial Hypertension (RELIEVE-PAH)

Condition:   Pulmonary Arterial Hypertension
Intervention:   Device: V-Wave Interatrial Shunt
Sponsor:   V-Wave Ltd
Not yet recruiting

A Pharmacokinetics Study for Pediatric Participants With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Tadalafil- Tablet or Oral suspension
Sponsor:   Eli Lilly and Company
Completed

Oral CXA-10 in Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: CXA-10
Sponsors:   University of Pittsburgh;   National Heart, Lung, and Blood Institute (NHLBI);   Complexa, Inc.
Not yet recruiting

Cardiac Metabolic Remodeling After Pulmonary Vasodilator Therapy in Pulmonary Arterial Hypertension: A Pilot Study

Conditions:   Pulmonary Arterial Hypertension;   Right-Sided Heart Failure
Intervention:   Other: PET/MRI
Sponsors:   University of Wisconsin, Madison;   United Therapeutics
Recruiting

Rehabilitation for Patients With Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Other: Pulmonary rehabilitation
Sponsor:   KU Leuven
Recruiting

A Study to Evaluate ALN-AGT01 in Patients With Hypertension

Condition:   Hypertension
Interventions:   Drug: ALN-AGT01;   Drug: ALN-AGT01-Matching Placebo;   Drug: Irbesartan;   Drug: Irbesartan-Matching Placebo
Sponsor:   Alnylam Pharmaceuticals
Recruiting

Study of Oral Treprostinil in Subjects With Pulmonary Hypertension (PH) Associated With Heart Failure With Preserved Ejection Fraction (HFpEF)

Condition:   Pulmonary Hypertension Associated With HFpEF
Intervention:   Drug: Oral Treprostinil
Sponsor:   United Therapeutics
Recruiting

Diet Intervention for Hypertension: Adaptation and Dissemination to Native Communities

Condition:   Hypertension
Interventions:   Behavioral: DASH Groceries + Weekly Sessions;   Behavioral: Groceries + Brochure
Sponsors:   Washington State University;   Oklahoma State University
Recruiting

Fluoxetine in Pulmonary Arterial Hypertension (PAH) Trial

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Fluoxetine
Sponsor:   University of Texas Southwestern Medical Center
Completed

Clinical Study Evaluating the Effects of First-line Oral cOmbination theraPy of maciTentan and tadalafIl in Patients With Newly Diagnosed pulMonary Arterial Hypertension (OPTIMA)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: macitentan;   Drug: tadalafil
Sponsor:   Actelion
Terminated

Biomarkers in Pediatric Congenital Heart Disease and PAH

Conditions:   Congenital Heart Disease;   Pulmonary Arterial Hypertension
Intervention:   Other: Blood test
Sponsor:   University Medical Center Groningen
Recruiting

Multicomponent Intervention to Improve Hypertension Control in Central America

Condition:   Arterial Hypertension
Intervention:   Other: Multicomponent intervention
Sponsors:   Institute of Nutrition of Central America and Panama;   Tulane University School of Public Health and Tropical Medicine;   Institute for Clinical Effectiveness and Health Policy;   Colorado School of Public Health;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Association of Hypertensive Disorder of Pregnancy With Sleep-disordered Breathing.

Conditions:   Hypertensive Disorder of Pregnancy;   Sleep-disordered Breathing
Intervention:  
Sponsor:   The Cooper Health System
Recruiting

Endothelial Cell Dysfunction in Pulmonary Hypertension

Condition:   Secondary Pulmonary Arterial Hypertension
Intervention:   Procedure: Heart Catheterization
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed

Renal Sympathetic Denervation by Iberis System in Patients With Uncontrolled Hypertension - Iberis-HTN Registry

Condition:   Resistant Hypertension
Intervention:   Device: Renal Denervation
Sponsor:   Terumo Europe N.V.
Terminated

Oral Treprostinil in Subjects With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction

Conditions:   Pulmonary Hypertension;   Heart Failure With a Preserved Ejection Fraction
Interventions:   Drug: Oral treprostinil;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting

Health Disparities in Hypertension

Conditions:   Hypertension;   Cardiovascular Risk Factor
Intervention:   Behavioral: Forced Desynchrony
Sponsor:   Oregon Health and Science University
Recruiting

HELP-HY: Health Education and sLeep Program in HYpertension

Conditions:   Prehypertension;   Hypertension
Interventions:   Behavioral: Sleep Enhancement;   Behavioral: Health Education
Sponsors:   Mayo Clinic;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

A Study Investigating Routine Practice of Chronic Thromboembolic Pulmonary Hypertension Management in EMEA Countries

Condition:   Hypertension, Pulmonary
Intervention:   Other: Standard of care
Sponsor:   Bayer
Active, not recruiting

Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer

Condition:   Breast Carcinoma
Intervention:   Other: Laboratory Biomarker Analysis
Sponsor:   National Cancer Institute (NCI)
Recruiting

Safety and Efficacy of ENV515 Travoprost Extended Release (XR) in Patients With Bilateral Ocular Hypertension or Primary Open Angle Glaucoma

Condition:   Glaucoma and Ocular Hypertension
Interventions:   Drug: ENV515-3 Travoprost XR;   Drug: ENV515-1 Travoprost XR;   Drug: ENV515-3-2 Travoprost XR
Sponsor:   Envisia Therapeutics
Completed

Clinical Trial to Evaluate the Efficacy and Safety of OLOMAX Tab (Olmesartan 20 mg/Amlodipine 5 mg/Rosuvastatin 5 or 10 mg) in Hypertension Patients With Low-Intermediate Risk for Cardiovascular Disease

Conditions:   Hypertension;   Dyslipidemias
Interventions:   Drug: OLOMAX 20/5/5mg;   Drug: OLOMAX 20/5/10mg;   Drug: Olmesartan 20 mg/Amlodipine 5 mg
Sponsor:   Daewoong Pharmaceutical Co. LTD.
Recruiting

Genetic and Environmental Determinants That Control Metabolism in Pulmonary Hypertension

Conditions:   Iron-sulfur Cluster Deficiency;   Pulmonary Hypertension;   Friedreich Ataxia
Interventions:   Procedure: Right Heart Catheterization;   Other: Blood draw
Sponsor:   University of Pittsburgh
Completed

Evaluation of the Duration of Effect of Bimatoprost SR in Participants With Open-angle Glaucoma or Ocular Hypertension

Conditions:   Glaucoma, Open-Angle;   Ocular Hypertension
Intervention:   Drug: Bimatoprost (SR)
Sponsor:   Allergan
Recruiting

Optimizing Gestational Weight Gain, Birth Weight and Other Perinatal Outcomes Among Pregnant Women at Risk of Hypertension in Pregnancy

Conditions:   Hypertension, Pregnancy-Induced;   Hypertension, Essential Hypertension;   Hypertension; Pre-Eclampsia;   Hypertension in Pregnancy
Intervention:   Device: Self monitoring of blood pressure using Health Gauge Device and monthly monitoring of weight gain
Sponsors:   International Centre for Diarrhoeal Disease Research, Bangladesh;   Bill and Melinda Gates Foundation;   Salu Design Group
Recruiting

Efficacy and Safety of Ambrisentan in Children 8-18yrs

Condition:   Hypertension, Pulmonary
Interventions:   Drug: Ambrisentan - low dose;   Drug: Ambrisentan - high dose
Sponsor:   GlaxoSmithKline
Terminated

Pulmonary Hypertension, Hypoxia and Sickle Cell Disease

Conditions:   Chuvash Polycythemia;   Cerebrovascular Disease;   Pulmonary Hypertension;   Sickle Cell Anemia
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Mechanisms of Intradialytic Hypertension

Conditions:   Renal Failure Chronic Requiring Hemodialysis;   Haemodialysis-induced Symptom;   Hypertension
Interventions:   Other: Mindfulness Meditation;   Other: Health Education
Sponsors:   Emory University;   Satellite Healthcare
Recruiting

Controlling and Lowering Blood Pressure With The MOBIUSHD™ (CALM-FIM_EUR)

Condition:   Hypertension
Intervention:   Device: MobiusHD
Sponsor:   Vascular Dynamics, Inc.
Active, not recruiting

An Integrated Assessment of the Safety and Effectiveness of Bexagliflozin for the Management of Essential Hypertension

Condition:   Essential Hypertension
Interventions:   Drug: Bexagliflozin;   Drug: Placebo
Sponsor:   Theracos
Completed

Controlling and Lowering Blood Pressure With The MOBIUSHD™

Condition:   Hypertension
Intervention:   Device: MobiusHD™
Sponsor:   Vascular Dynamics, Inc.
Active, not recruiting

Observational Study of the EnligHTN Renal Denervation System in Europe

Condition:   Uncontrolled Hypertension
Intervention:   Device: EnligHTN™ Renal Denervation System
Sponsor:   Abbott Medical Devices
Completed

Metformin for Pulmonary Hypertension HFpEF

Conditions:   Pulmonary Hypertension;   Heart Failure
Interventions:   Drug: Metformin;   Drug: Placebo oral capsule
Sponsors:   Marc A. Simon;   National Institute on Aging (NIA)
Recruiting

Safety and Efficacy of Ophthalmic Phentolamine Mesylate in Glaucoma

Conditions:   Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Phentolamine Mesylate Ophthalmic Solution 1%;   Other: Phentolamine Mesylate Ophthalmic Solution Vehicle (Placebo)
Sponsor:   Ocuphire Pharma, Inc.
Completed

High-Intensity Interval Versus Moderate-Intensity Continuous Water Based Exercise in Hypertensive Older Individuals

Condition:   Hypertension
Interventions:   Other: High Intensity Interval Exercise in Heated Water-Based;   Other: Continuous Moderate Exercise in Heated Water-Based;   Other: Control Group
Sponsors:   Universidade Estadual Paulista Júlio de Mesquita Filho;   Fundação de Amparo à Pesquisa do Estado de São Paulo
Not yet recruiting

Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Adempas (Riociguat, BAY63-2521);   Drug: Sildenafil;   Drug: Tadalafil
Sponsor:   Bayer
Active, not recruiting

Improving Chronic Disease Management With Pieces

Conditions:   Chronic Kidney Disease;   Diabetes;   Hypertension;   High BP;   Type 2 Diabetes
Intervention:   Other: Collaborative Model of Primary care and Subspecialty care
Sponsors:   University of Texas Southwestern Medical Center;   Parkland Center for Clinical Innovation;   Parkland Health & Hospital System;   Texas Health Resources;   Connecticut Center for Primary Care;   Dallas VA Research Corporation;   G-Health Enterprises;   National Institutes of Health (NIH);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Assessment of the Efficacy and Tolerability of the Fixed-dose Combination of Bisoprolol/Perindopril in Patients With Arterial Hypertension and Stable CAD in Daily Clinical Practice

Conditions:   Arterial Hypertension;   CHD - Coronary Heart Disease
Intervention:   Drug: bisoprolol/perindopril FDC
Sponsor:   Servier Russia
Recruiting

Effects of the Dietary Approaches to Stop Hypertension(DASH) Sodium-restricted Diet in Diastolic Heart Failure

Conditions:   Diastolic Heart Failure;   Hypertensive Heart Disease
Intervention:   Behavioral: DASH/sodium-restricted diet (SRD)
Sponsor:   University of Michigan
Completed

Efficacy of Fixed-doses of Antihypertensive and Statin Drugs

Conditions:   Hypertension;   Dyslipidemia
Interventions:   Drug: Viena II 160/10;   Drug: Viena II 190/10;   Drug: Viena II 160/12;   Drug: Viena II 190/12
Sponsor:   EMS
Withdrawn

A Study to Evaluate Efficacy and Safety of CS-3150 in Japanese Hypertensive Subjects

Condition:   Essential Hypertension
Interventions:   Drug: CS-3150;   Drug: placebo;   Drug: eplerenone
Sponsor:   Daiichi Sankyo, Inc.
Completed

Randomized Clinical Trial to Increase Physical Activity After a a Hypertensive Pregnancy

Conditions:   Hypertension in Pregnancy;   Preeclampsia;   Gestational Hypertension
Intervention:   Behavioral: Social incentives-based program
Sponsor:   University of Pennsylvania
Not yet recruiting

Center of Research Translation (CORT) Project 2

Conditions:   Pre-hypertension;   JNC 7 Stage I Hypertension
Interventions:   Drug: Allopurinol;   Drug: Placebo
Sponsors:   University of Alabama at Birmingham;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Completed

PRIMEx - A Study of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH)

Condition:   PAH
Interventions:   Drug: 75mg CXA-10;   Drug: 150mg CXA-10;   Other: Placebo
Sponsors:   Complexa, Inc.;   Medpace, Inc.;   Philips Healthcare;   Cardiovascular Clinical Science Foundation;   MicroConstants;   Innovative Analytics;   Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Recruiting

Impact of Community Health Workers on Adherence to Therapy for Non-Communicable Chronic Disease in Chiapas, Mexico

Conditions:   Hypertension;   Diabetes Mellitus, Type 2
Intervention:  
Sponsors:   Brigham and Women's Hospital;   Harvard University
Completed

Long-term Safety and Efficacy Extension Trial of Bimatoprost SR

Conditions:   Open-Angle Glaucoma;   Ocular Hypertension
Intervention:   Drug: Bimatoprost SR
Sponsor:   Allergan
Recruiting

Use of Short Text Messages to Promote Medication Adherence in Hypertensive Patients

Conditions:   Hypertension;   Adherence, Treatment
Interventions:   Other: Educational short message texts;   Other: Adherence short message texts
Sponsors:   Federal University of Bahia;   Medtronic Foundation
Not yet recruiting

Central Hemodynamic and Sodium Urinary

Condition:   Hypertension
Intervention:   Diagnostic Test: Evaluate if the individuals are resistant hypertensive patients
Sponsors:   Hospital de Base;   Sao Jose do Rio Preto Medical School
Active, not recruiting

Arterial Stiffness as a Predictor of Response to Renal Sympathetic Denervation

Condition:   Therapy Resistant Arterial Hypertension
Intervention:   Device: Renal sympathetic denervation (RDN)
Sponsor:   University of Leipzig
Recruiting

Role of Nitric Oxide in Malaria

Conditions:   Malaria;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

SPYRAL HTN-ON MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Recruiting

A Study to Assess the Safety, Tolerability, and Hemodynamic Response of PB1046 in Subjects With PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: PB1046 Subcutaneous Injection
Sponsor:   PhaseBio Pharmaceuticals Inc.
Completed

Phase 2 Study to Assess Safety, Tolerability and Efficacy of Once Weekly SC PB1046 in Subjects With Symptomatic PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: PB1046
Sponsor:   PhaseBio Pharmaceuticals Inc.
Recruiting

Angiotensin II in General Anesthesia

Condition:   Hypertension
Intervention:   Drug: Angiotensin II
Sponsor:   Wake Forest University Health Sciences
Recruiting

An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease;   Combined Pulmonary Fibrosis and Emphysema
Intervention:   Drug: Inhaled Treprostinil
Sponsor:   United Therapeutics
Enrolling by invitation

REtinaL Imaging & Ambulatory BLood PrEssure

Conditions:   Hypertension;   Blood Pressure
Intervention:  
Sponsors:   University of Edinburgh;   Optos, PLC;   NHS Lothian
Recruiting

Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease;   Combined Pulmonary Fibrosis and Emphysema
Interventions:   Drug: Inhaled Treprostinil;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting

The PCORnet Blood Pressure Home Monitoring Study

Condition:   Hypertension
Interventions:   Device: Smartphone-linked HBPM and associated app;   Device: Standard HBPM
Sponsors:   University of California, San Francisco;   Patient-Centered Outcomes Research Institute
Recruiting

Effect of a Multi-component Education Program on Salt Reduction in Adults

Conditions:   Blood Pressure;   Hypertension
Interventions:   Behavioral: Salt reduction program;   Behavioral: Healthy lifestyle program
Sponsors:   Academia Cuf Descobertas;   NOVA Medical School;   Jeronimo Martins
Completed

Hemodynamic Evaluation of Levosimendan in Patients With PH-HFpEF

Conditions:   Hypertension Pulmonary Secondary;   Heart Failure, Right Sided;   Heart Failure With Normal Ejection Fraction
Interventions:   Drug: Levosimendan;   Drug: Matching Placebo
Sponsor:   Tenax Therapeutics, Inc.
Recruiting

Adiposity and Endothelin Receptor Function

Condition:   Hypertension
Interventions:   Drug: Candesartan;   Drug: Placebo
Sponsors:   Augusta University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx

Condition:   Hypertension
Interventions:   Drug: IONIS-AGT-LRx;   Drug: Placebo
Sponsor:   Ionis Pharmaceuticals, Inc.
Recruiting

Relative Bioavailability Study of Marketed and Lower Dose Ambrisentan in Healthy Adult Participants

Condition:   Hypertension, Pulmonary
Interventions:   Drug: AMB new formulation (1 mg);   Drug: Reference AMB (5 mg)
Sponsor:   GlaxoSmithKline
Recruiting

Antihypertensive Effect of Fermented Milk With Lactococcus Lactis on Prehypertensive Subjects

Condition:   Hypertension
Interventions:   Dietary Supplement: Fermented milk;   Dietary Supplement: Acidified milk
Sponsor:   Centro de Investigación en Alimentación y Desarrollo A.C.
Completed

Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients

Conditions:   Hypertension Pulmonary Secondary Heart Failure;   Right Sided Heart Failure With Normal Ejection Fraction;   Heart Failure With Normal Ejection Fraction
Intervention:   Drug: Levosimendan 2.5 mg/ml Injectable Solution
Sponsor:   Tenax Therapeutics, Inc.
Recruiting

BedMed-Frail: Does the Potential Benefit of Bedtime Antihypertensive Prescribing Extend to Frail Populations?

Conditions:   Hypertension;   Dementia
Intervention:   Other: Bedtime administration of the participant's pre-existing antihypertensive medications
Sponsors:   University of Alberta;   Alberta Innovates Health Solutions;   Canadian Institutes of Health Research (CIHR);   EnACt
Not yet recruiting

A Phase 2 Exploratory Study of CS-3150 in Japanese Hypertensive Patients With Moderate Renal Impairment

Condition:   Hypertension
Intervention:   Drug: CS-3150
Sponsor:   Daiichi Sankyo, Inc.
Completed

A Cardiosleep Research Program on Obstructive Sleep Apnea, Blood Pressure Control and Maladaptive Myocardial Remodeling

Conditions:   Hypertension,Essential;   Obstructive Sleep Apnea
Interventions:   Device: Mandibular Advancement Device;   Device: Continuous Positive Airway Pressure
Sponsors:   National University, Singapore;   Ng Teng Fong General Hospital;   National University Hospital, Singapore
Recruiting

Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia

Conditions:   Sickle Cell Disease;   Chronic Kidney Disease;   Pulmonary Hypertension
Intervention:   Drug: Erythropoietin and Hydroxyurea
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Improving Blood Pressure Control in Diverse Populations by Measuring Accurately, Acting Rapidly, and Partnering With Patients

Condition:   Hypertension
Interventions:   Other: Self-Guided M.A.P. BP Improvement Program;   Other: Full Support M.A.P. BP Improvement Program
Sponsors:   University of California, San Francisco;   Patient-Centered Outcomes Research Institute
Active, not recruiting

Implantable System for Remodulin Post-Approval Study

Condition:   Pulmonary Arterial Hypertension
Intervention:   Combination Product: Implantable System for Remodulin (treprostinil)
Sponsors:   Medtronic Cardiac Rhythm and Heart Failure;   United Therapeutics
Not yet recruiting

Remote Dietary Counseling to Promote Healthy Diet and Blood Pressure

Conditions:   Blood Pressure;   High Blood Pressure;   Dietary Modification;   Overweight and Obesity
Interventions:   Behavioral: Self-Guided Approach;   Behavioral: Dietitian-led Approach
Sponsor:   Geisinger Clinic
Recruiting

Non-invasive Method for Predicting the Presence of Gastroesophageal Varices in Patients With Cirrhosis

Conditions:   Gastroesophageal Varices;   Portal Hypertension
Intervention:  
Sponsor:   Nanfang Hospital of Southern Medical University
Recruiting

Perioperative Care of HVPG Measurement (CHESS1904): An International Multicenter Survey

Conditions:   Portal Hypertension;   Cirrhosis, Liver
Intervention:   Other: Questionnaire
Sponsors:   Hepatopancreatobiliary Surgery Institute of Gansu Province;   LanZhou University;   Shandong Provincial Hospital;   Xingtai People's Hospital;   Zhejiang University;   Ankara University;   Chiba University Graduate School of Medicine;   Universitas Indonesia, Cipto Mangunkusumo National General Hospital;   S. Orsola-Malpighi Hospital, University of Bologna;   Universidade Federal de Pernambuco;   Hanyang University College of Medicine
Recruiting

A Study Evaluating the Utility of Ambrisentan in Lowering Portal Pressure in Patients With Liver Cirrhosis

Conditions:   Cirrhosis;   Portal Hypertension;   Ascites
Intervention:   Drug: Ambrisentan
Sponsor:   Noorik Biopharmaceuticals AG
Recruiting

Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients

Conditions:   Type 2 Diabetes;   High Blood Pressure;   Arthritis;   Obesity
Interventions:   Drug: Metformin;   Drug: Val, Cel and Met XR Low;   Drug: Val, Cel and Met XR High
Sponsors:   ARKAY Therapeutics;   Albany Medical College
Not yet recruiting

Pilot for a Community Pharmacy Service Model: Impact of a Pharmacist Monitored Patient Blood Pressure Readings

Condition:   Hypertension
Intervention:   Other: Incentivized Care
Sponsor:   Virginia Commonwealth University
Recruiting

Comparison of the Medication Adherence of Patients Treated With Telmisartan/Hydrochlorothiazide or Telmisartan/Amlodipine Fixed Dose Combination (FDC) Versus Double-pill Combination Therapy in Real-world Japanese Therapeutic Practice

Condition:   Hypertension
Interventions:   Drug: subjects treated with telmisartan/hydrochlorothiazide;   Drug: Subjects treated with Telmisartan and amlodipine;   Drug: subjects treated with Telmisartan+hydrochlorothiazide double-pill combination group;   Drug: subjects treated with telmisartan+amlodipine double pill
Sponsor:   Boehringer Ingelheim
Not yet recruiting

Endothelin Receptor Function and Acute Stress

Condition:   Hypertension
Interventions:   Drug: Bosentan;   Drug: Placebo
Sponsors:   Augusta University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

Conditions:   PAH;   Pulmonary Hypertension;   Pulmonary Arterial Hypertension;   Hypertension;   Connective Tissue Diseases;   Familial Primary Pulmonary Hypertension;   Vascular Diseases;   Cardiovascular Diseases;   Hypertension, Pulmonary;   Lung Diseases;   Respiratory Tract Disease
Intervention:   Drug: Ralinepag
Sponsor:   United Therapeutics
Enrolling by invitation

A Nurse-led Intervention to Extend the HIV Treatment Cascade for Cardiovascular Disease Prevention

Conditions:   HIV/AIDS;   Hypertension;   Hyperlipidemias
Interventions:   Other: Multi-component intervention;   Other: General prevention education
Sponsors:   Case Western Reserve University;   Duke University;   University Hospitals Cleveland Medical Center;   MetroHealth Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

The Effect of Sodium Reduction on Blood Pressure and Physical Function in Older Adults

Conditions:   Hypertension;   Physical Disability;   Aging
Intervention:   Other: Dietary intervention
Sponsors:   Hebrew Rehabilitation Center, Boston;   Hebrew SeniorLife;   Beth Israel Deaconess Medical Center
Recruiting

Haemodynamic Abnormalities Recorded With Cardiac Catheterization Along With Body's Surface Micro-accelerometers (KT-KCG)

Conditions:   Heart Failure;   Pulmonary Hypertension
Intervention:   Device: Ballistocardiography and seismocardiography
Sponsor:   Erasme University Hospital
Not yet recruiting

Prepared Meals to Prime and Perpetuate Reduced Dietary Sodium Intake in Hemodialysis

Conditions:   Hypertension in Dialysis Patients;   Fluid Overload in Dialysis Patients
Interventions:   Other: Sodium Restricted Meals;   Other: Control
Sponsor:   Tufts Medical Center
Recruiting

Marinobufagenin as a Target for DIGIBIND in Preeclampsia

Condition:   Preeclampsia
Intervention:  
Sponsor:   National Institute on Aging (NIA)
Completed

Biomarker Guided Therapies in Stage A/B Heart Failure

Conditions:   Hypertension;   Diabetes;   Cardiovascular Disease
Interventions:   Drug: Carvedilol;   Drug: Spironolactone
Sponsors:   VA Office of Research and Development;   Baylor College of Medicine
Active, not recruiting

Digital Home Blood Pressure Monitoring in Type B Aortic Dissection Patients

Conditions:   Aortic Dissection;   Hypertension
Intervention:   Device: Withings Digital Blood Pressure Monitor
Sponsor:   The Cleveland Clinic
Recruiting

A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Conditions:   PAH;   Pulmonary Hypertension;   Pulmonary Arterial Hypertension;   Hypertension;   Connective Tissue Diseases;   Familial Primary Pulmonary Hypertension;   Vascular Diseases;   Cardiovascular Diseases;   Hypertension, Pulmonary;   Lung Diseases;   Respiratory Tract Disease
Interventions:   Drug: Ralinepag;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting

Be-HealthY: Behavioral Risk Factors for Poor Vascular Health in Youth

Conditions:   Prehypertension;   Hypertension;   Overweight and Obesity;   Elevated Blood Pressure;   Endothelial Dysfunction;   Vascular Stiffness;   Sleep
Interventions:   Diagnostic Test: Cardiovascular Assessments;   Diagnostic Test: Actigraphy;   Diagnostic Test: Laboratory assessments;   Diagnostic Test: Emotional/Behavioral Assessments
Sponsors:   Johns Hopkins University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Effect of Beetroot Juice on Blood Pressure Regulation in Post Menopausal Women

Condition:   Postmenopausal Women
Interventions:   Drug: Beetroot juice;   Drug: Beetroot juice placebo
Sponsor:   Penn State University
Active, not recruiting

Stand & Move at Work

Conditions:   Obesity;   Hypertension;   Diabetes
Interventions:   Device: Sit-Stand workstation;   Behavioral: Move
Sponsors:   Arizona State University;   University of Minnesota - Clinical and Translational Science Institute
Completed

Sildenafil Administration to Treat Neonatal Encephalopathy

Condition:   Neonatal Encephalopathy
Interventions:   Drug: Sildenafil;   Drug: Ora-Blend
Sponsor:   McGill University Health Centre/Research Institute of the McGill University Health Centre
Active, not recruiting

Omphaloceles and Associated Malformations

Condition:   Omphalocele
Intervention:  
Sponsor:   University Hospital Tuebingen
Recruiting

DKK3 for Prognosis and Monitoring of GFR Loss in Heart Failure

Conditions:   Heart Failure;   Chronic Kidney Diseases
Intervention:   Diagnostic Test: No intervention
Sponsor:   University of Giessen
Recruiting

Lung Transplant G0 (LTGO): Improving Self-Management of Exercise After Lung Transplantation

Conditions:   Exercise;   Lung Transplantation
Interventions:   Behavioral: LTGO-Home Based Exercise;   Behavioral: Enhanced Usual Care
Sponsors:   University of Pittsburgh;   National Institute of Nursing Research (NINR)
Recruiting

Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV

Condition:   Stress Disorders, Post-Traumatic
Interventions:   Procedure: Microneurography;   Behavioral: Combat virtual reality video clip;   Procedure: Handgrip Exercise;   Procedure: Cold Pressor Test (CPT);   Drug: Sodium Nitroprusside (SNP);   Drug: Phenylephrine;   Drug: Losartan;   Drug: Atenolol
Sponsor:   Emory University
Recruiting

Genetics of Type 2 Diabetes Among Han Chinese

Conditions:   Diabetes;   Hypertension
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Completed

Race, Natriuretic Peptides and Physiological Perturbations

Conditions:   Healthy;   Pre Hypertension
Interventions:   Other: Exercise capacity VO2 max determination;   Dietary Supplement: Standardized meals;   Other: Exercise challenge;   Drug: Metoprolol Succinate ER
Sponsor:   University of Alabama at Birmingham
Recruiting

Selected Disorders and Sleep Bruxism

Conditions:   Sleep Bruxism;   Hypertension;   Thyroid Dysfunction;   Mental Status Change;   Sleep Apnea;   Sleep Disorders;   Cardiovascular Risk Factor;   Cardiovascular Diseases;   Temporomandibular Disorder
Intervention:   Drug: Buspirone
Sponsor:   Wroclaw Medical University
Enrolling by invitation

Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Adolescent Bariatrics: Assessing Health Benefits and Risk

Condition:   Obesity
Intervention:  
Sponsors:   University of Colorado, Denver;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   Children's Hospital Medical Center, Cincinnati;   University of Pittsburgh Medical Center;   University of Alabama at Birmingham;   Nationwide Children's Hospital;   Texas Children's Hospital;   University of Washington;   Sanford Health
Enrolling by invitation

Early Detection and Prevention of Mild Cognitive Impairment Due to Cerebrovascular Disease

Conditions:   Cerebrovascular Disease;   Mild Cognitive Impairment
Intervention:   Behavioral: Heart Health Intervention
Sponsor:   Gregory Jicha, 323-5550
Completed

Establishment of a Perinatal Database and a Bank of Biological Materials

Conditions:   Preterm Labor;   Preterm Birth;   Pregnancy
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed

Study to Evaluate CORT125134 in Participants With Cushing's Syndrome

Condition:   Cushing's Syndrome
Intervention:   Drug: CORT125134
Sponsor:   Corcept Therapeutics
Completed

High Resolution Imaging of Retinal Vessels as a Biomarker of Cardiovascular Disease in Patients With Renal Insufficiency - RI

Conditions:   Retinal Imaging;   Cardiovascular Biomarker;   Renal Insufficiency
Intervention:   Diagnostic Test: wall-to-lumen ratio measurement
Sponsors:   Ramsay Générale de Santé;   Dr Céline FAURE
Active, not recruiting

Home-based Exercise in Renal Transplant Recipients

Condition:   Kidney Transplant; Complications
Intervention:   Other: Home-based Exercise
Sponsor:   University of Leicester
Not yet recruiting

Comparison of Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients

Conditions:   Trauma;   Shock, Traumatic
Interventions:   Drug: Etomidate Injection 0.2 mg/kg;   Drug: Ketamine injection 2 mg/kg
Sponsors:   Ajou University School of Medicine;   Unimedics (http://unimedics.co.kr)
Recruiting

Exploring the Mechanisms of Indoxyl Sulfate Production by Oral Tryptophan Challenge Test

Conditions:   Healthy;   Chronic Kidney Diseases
Intervention:   Dietary Supplement: Doctor's Best L-Tryptophan
Sponsor:   Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Not yet recruiting

Prevalence of Primary Aldosteronism Among Hypertensive Patients

Conditions:   Primary Aldosteronism;   Atrial Fibrillation
Intervention:   Diagnostic Test: Primary Hyperaldosteronism diagnostic
Sponsor:   Centre Hospitalier de PAU
Not yet recruiting

The Effect of Obesity on Pregnancy and Fetal Outcome in Glucose Tolerant Mothers

Condition:   Obesity
Intervention:  
Sponsor:   University Malaysia Sarawak
Completed

Treatment for Non-Alcoholic Fatty Liver With Different Doses of Vitamin E

Condition:   Fatty Liver
Interventions:   Drug: Vitamin E 200 IU/d;   Drug: Vitamin E 400 IU/d;   Drug: Vitamin E 800 IU/d;   Behavioral: Diet and Exercise
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Effects of Propranolol on Responses to Drug-Related Imagery Scripts

Condition:   Cocaine Dependence
Interventions:   Drug: Propranolol;   Drug: Placebo
Sponsor:   National Institute on Drug Abuse (NIDA)
Terminated

Cardiorenal Protective Diet

Conditions:   Chronic Kidney Diseases;   Cardiovascular Diseases;   Hypertension
Intervention:   Other: Fruits and Vegetables
Sponsor:   Baylor Research Institute
Recruiting

Clonidine for Relapse Prevention in Buprenorphine-Maintenance Patients

Condition:   Opioid-Related Disorders
Interventions:   Drug: Clonidine;   Drug: Placebo
Sponsor:   National Institute on Drug Abuse (NIDA)
Completed

Intensive Lifestyle Intervention for Remission of Metabolic Syndrome

Condition:   Metabolic Syndrome
Interventions:   Behavioral: Intensive Lifestyle Intervention;   Behavioral: Conventional Treatment
Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University
Not yet recruiting

Evaluation of Adrenal Suppression Potential and Pharmacokinetics of Halobetasol Lotion 0.05%

Condition:   Plaque Psoriasis
Intervention:   Drug: Halobetasol Topical Lotion
Sponsor:   Sun Pharmaceutical Industries Limited
Completed

Heart Catheterization Using Magnetic Resonance Imaging (MRI) Fluoroscopy and Passive Guidewires

Conditions:   Pulmonary Artery Hypertension;   Congenital Heart Disease;   Structural Heart Disease
Intervention:   Procedure: MRI Right Heart guidewire catheterization
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Mecamylamine for Autonomic Dysreflexia Prophylaxis

Condition:   Spinal Cord Injuries
Intervention:   Drug: Mecamylamine Oral Tablet
Sponsor:   Wayne State University
Recruiting

A Comparative Evaluation of a MPS Dressing and a CMC Dressing on Subjects With Lower Extremity Venous Ulcers

Condition:   Venous Leg Ulcer
Interventions:   Device: Marine polysaccharide dressing;   Device: Carboxymethylcellulose dressing
Sponsor:   Medline Industries
Recruiting

Preclinical Cardiomyopathy and Autonomic Function in Type 1 Diabetes

Conditions:   Diabetes Mellitus, Type 1;   Diabetic Cardiomyopathies;   Autonomic Neuropathy, Diabetic
Intervention:  
Sponsor:   Roberto Léo da Silva
Completed

Long Acting Buprenorphine Injection Compared to Sublingual Buprenorphine/Naloxone Films

Condition:   Opioid Use
Interventions:   Drug: Suboxone® SL;   Drug: Sublocade®
Sponsor:   Wake Forest University Health Sciences
Not yet recruiting

Evaluation of Kinesophobia in Patients With Metabolic Syndrome

Conditions:   Kinesiophobia;   Metabolic Syndrome
Intervention:   Other: Kinesiophobia
Sponsor:   Erol Olcok Corum Training and Research Hospital
Recruiting

Study of Clonidine Efficacy for the Treatment of Impulse Control Disorders in Parkinson's Disease:

Conditions:   Parkinson's Disease;   Mpulse Control Disorders
Interventions:   Drug: placebo;   Drug: Clonidine
Sponsor:   Hospices Civils de Lyon
Recruiting

Pulmonary Vascular Impairment in Chronic Obstructive Pulmonary Disease (COPD) Assessed by MRI

Condition:   Chronic Obstructive Pulmonary Disease (COPD)
Intervention:   Diagnostic Test: chest Magnetic Resonance Imaging (MRI) using Gadolinium-based contrast agent
Sponsor:   Assistance Publique Hopitaux De Marseille
Active, not recruiting

Preliminary Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low-weight Infants

Condition:   Patent Ductus Arteriosus
Interventions:   Device: Cather closure of patent ductus arteriosus (PDA);   Other: Conservative management of patent ductus arteriosus (PDA)
Sponsors:   Nationwide Children's Hospital;   University of Tennessee Health Science Center
Recruiting

Acthar as Rescue Therapy for Transplant Glomerulopathy in Kidney Transplant Recipients

Conditions:   Proteinuria;   Transplant Glomerulopathy
Intervention:   Drug: Acthar
Sponsors:   University of Illinois at Chicago;   Mallinckrodt
Terminated

AGNES - Aging Nephropathy Study, a Prospective Observational Cohort of Chronic Kidney Disease in Elderly Patients

Conditions:   Chronic Kidney Diseases;   Elderly;   Mortality;   Renal Replacement Therapy
Intervention:  
Sponsor:   University of Sao Paulo General Hospital
Recruiting

Postoperative and Opioid Free Anesthesia

Conditions:   Anesthesia;   Opioid-Related Disorders
Interventions:   Drug: Dexmedetomidine;   Drug: Remifentanil
Sponsor:   Rennes University Hospital
Terminated

Effects of Mitochondrial-targeted Antioxidant on Mild Cognitive Impairment (MCI) Patients

Conditions:   Alzheimer Disease, Early Onset;   Mild Cognitive Impairment
Interventions:   Dietary Supplement: MitoQ;   Dietary Supplement: Placebo
Sponsor:   University of Nebraska, Omaha
Not yet recruiting

Pre-emptive Scalp Infiltration With Methylprednisolone Plus Ropivacaine for Postoperative Pain After Craniotomy

Condition:   Pain, Postoperative
Interventions:   Drug: The MP/RP group;   Drug: The RP group
Sponsor:   Beijing Tiantan Hospital
Not yet recruiting

Investigating Idiopathic Pulmonary Fibrosis in Greece (INDULGE IPF)

Condition:   Idiopathic Pulmonary Fibrosis
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Scalp Infiltration With Diprospan Plus Ropivacaine for Postoperative Pain After Craniotomy in Adults

Conditions:   Pain, Postoperative;   Post-Craniotomy Headache
Interventions:   Drug: The DR group;   Drug: The R group
Sponsor:   Beijing Tiantan Hospital
Recruiting

Cost-effectiveness and Safety of the CADScorSystem in Patients With Symptoms Suggestive of Stable Coronary Artery Disease.

Condition:   Angina, Stable
Intervention:   Device: CAD-score
Sponsors:   Bispebjerg Hospital;   Region Hovedstaden;   Larix A/S;   Acarix;   Kai Hansens Fond;   Kai Houmann Nielsens Fond
Active, not recruiting

Mitigation of Radiation Pneumonitis and Fibrosis

Conditions:   Lung Cancer;   Radiation Pneumonitis
Interventions:   Drug: Enalapril;   Drug: placebo
Sponsor:   VA Office of Research and Development
Completed

Risk Assessment by Cardiovascular Biomarkers in Chronic Dialysis Patients

Condition:   Endstage Renal Disease
Intervention:  
Sponsor:   University Hospital, Basel, Switzerland
Active, not recruiting

Effects of Antibiotic Prophylaxis on Recurrent UTI in Children

Conditions:   Urinary Tract Infection;   Recurrent Urinary Tract Infection
Intervention:   Drug: Antibiotic Prophylaxis
Sponsors:   Lawson Health Research Institute;   University of Western Ontario, Canada
Completed

Uric Acid Lowering Trial in Youth Onset T2D

Conditions:   Diabetic Kidney Disease;   Hyperuricemia;   Diabetes;   Diabetes Mellitus, Type 2;   Type2 Diabetes;   Type 2 Diabetes Mellitus;   Diabetic Nephropathies;   Diabetes Complications
Intervention:   Drug: Pegloticase 8 MG/ML [Krystexxa]
Sponsor:   University of Colorado Denver School of Medicine Barbara Davis Center
Not yet recruiting

Parecoxib as an Adjuvant to Scalp Nerve Blocks for Relief of Post-craniotomy Pain

Conditions:   Pain, Postoperative;   Neurosurgery
Interventions:   Drug: Scalp blocks with ropivacaine plus parecoxib;   Drug: Scalp blocks with ropivacaine and intravenous parecoxib;   Drug: Scalp blocks with ropivacaine and intravenous saline
Sponsor:   Beijing Tiantan Hospital
Recruiting

Morbidity and Mortality in Autonomous Cortisol Secretion

Conditions:   Adrenal Incidentaloma;   Cortisol Overproduction
Intervention:  
Sponsor:   Region Skane
Active, not recruiting

Effect of a Low Residue Diet in Comparison to the Dietetic Recommendations From the INCan in Cervical Cancer Patients

Conditions:   Uterine Cervical Neoplasm;   Dietary Modification;   Radiation Toxicity;   Gastrointestinal Complication
Intervention:   Other: Dietary modification
Sponsors:   National Institute of Cancerología;   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Recruiting

The Effect of Intradialytic Combined Exercise on Physical Outcomes in End-Stage Renal Disease Patients

Conditions:   Kidney Failure, Chronic;   Exercise;   Physical Fitness
Interventions:   Other: Usual care with sham intervention;   Other: Intradialytic Combined Exercise
Sponsor:   Health Science Center of Xi’an Jiaotong University
Completed

Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function

Conditions:   Diabetes Mellitus, Type 1;   Nephropathy;   Diabetic Nephropathies;   Juvenile Diabetes;   Diabetes Mellitus Complication;   Autoimmune Diabetes;   Type 1 Diabetes Mellitus
Interventions:   Drug: Aminohippurate Sodium Inj 20%;   Drug: Iohexol Inj 300 mg/mL
Sponsor:   University of Colorado Denver School of Medicine Barbara Davis Center
Active, not recruiting

Lipidomics Screening of Anti-inflammatory Drugs and Drug Candidates in Vitro - Part A

Condition:   Healthy
Intervention:   Procedure: Blood draw
Sponsors:   University of Pennsylvania;   Eli Lilly and Company
Active, not recruiting

Systemic Sclerosis (SSc) Vasculopathy: Improved Clinical Monitoring and Treatment

Condition:   Rheumatologic Disease
Interventions:   Drug: BH4;   Other: Vasculopathy assessment;   Drug: Placebo
Sponsor:   VA Office of Research and Development
Recruiting

Enhanced Lifestyles for Metabolic Syndrome

Condition:   Metabolic Syndrome
Interventions:   Behavioral: Group-Based Program;   Behavioral: Self-Directed Program
Sponsors:   Rush University Medical Center;   University of Colorado, Denver;   Geisinger Clinic;   Rochester Institute of Technology;   University of Missouri, Kansas City
Recruiting

The Effect of the DASH Diet Containing Meat on Muscle and Metabolic Health in Older Adults

Conditions:   Obesity;   Sarcopenia;   Aging
Intervention:   Other: DASH diet containing daily intakes of red meat
Sponsor:   South Dakota State University
Completed

SOFI: A Quality Improvement Project to Standardize Use of Intravenous Fluids in Hospitalized Pediatric Patients

Conditions:   Intravenous Fluids;   Fluid and Electrolyte Imbalance;   ADH Inappropriate
Intervention:   Other: Education, clinical decision support tools
Sponsors:   Seattle Children's Hospital;   American Academy of Pediatrics
Active, not recruiting

Chronic Kidney Disease - Renal Epidemiology and Information Network

Condition:   Renal Insufficiency, Chronic
Intervention:  
Sponsors:   Institut National de la Santé Et de la Recherche Médicale, France;   Université Paris-Sud;   Agence de La Biomédecine;   Arbor Research Collaborative for Health;   Hospital Ambroise Paré Paris;   Centre Hospitalier Lyon Sud;   Nancy University Hospital;   Institut de Formation et de Recherche sur les Organisations Sanitaires et Sociales;   Biobanque de Picardie;   Centre National de Génotypage;   Institut des Maladies Métaboliques et Cardiovasculaires;   Etablissement Français du Sang;   Amiens University Hospital;   University Hospital, Bordeaux
Active, not recruiting

The Health Access and Recovery Peer Program

Conditions:   Hypertension;   Arthritis;   Coronary Artery Disease;   Hepatitis;   Diabetes;   Asthma;   Hyperlipidemia;   HIV
Intervention:   Behavioral: HARP Intervention
Sponsors:   Emory University;   National Institute of Mental Health (NIMH)
Completed

Understanding the Pathophysiology of Migraine Pain

Conditions:   Migraine Disorders;   Migraine, Classic;   Migraine Without Aura
Intervention:   Other: Nitroglycerin
Sponsor:   Montefiore Medical Center
Recruiting

Evaluation of Covered Stents Versus Bare Metal Stents for Endovascular Treatment of Chronic Ischemia Mesenteric Disease.

Conditions:   Chronic Mesenteric Ischemia;   Stent Stenosis
Interventions:   Procedure: endovascular angioplasty using covered stents;   Procedure: endovascular angioplasty using bare metal stents;   Device: Duplex-scan;   Device: computerized tomography scan (CT-scan);   Device: digital angiography;   Other: Short Form-36 (SF-36) questionnaire
Sponsor:   Hospices Civils de Lyon
Recruiting

Normotonic Partial Nephrectomy as Novel Approach in Treating Small Renal Masses

Conditions:   Renal Malignant Tumor;   Renal Tumor
Interventions:   Procedure: Normotonic partial nephrectomy;   Procedure: Hypotonic partial nephrectomy
Sponsor:   Saint Petersburg State University, Russia
Not yet recruiting

Best Rest: Rest Time Before Blood Pressure Measurement Trial

Conditions:   Hypertension;   Blood Pressure;   Cardiovascular Diseases;   Cardiovascular Risk Factor
Intervention:   Other: Timing of rest prior to blood pressure measurement
Sponsors:   Johns Hopkins University;   Vital Strategies
Not yet recruiting

HealthMatters@24/7 eLearning for People Supporting Adults With Intellectual and Developmental Disabilities

Conditions:   Obesity;   Hypertension;   Hypercholesterolemia;   Hyperglycemia
Intervention:   Other: Asynchronous, eLearning Intervention
Sponsor:   University of Illinois at Chicago
Active, not recruiting

BAY 43-9006 (Sorafenib) and Bevacizumab (Avastin) To Treat Solid Tumors

Condition:   Neoplasms
Interventions:   Drug: Bevacizumab;   Drug: BAY 43-9006
Sponsor:   National Cancer Institute (NCI)
Completed

Impact of INsulin Sensitivity on Cardiovascular Risk Markers During 10-20 Years of FOllow up

Conditions:   Diabetes Mellitus;   Hypertension;   Ischemic Heart Disease;   Stroke
Intervention:  
Sponsor:   Oslo University Hospital
Completed

Safe Kidney Care Cohort Study

Condition:   Chronic Kidney Disease
Intervention:  
Sponsors:   University of Maryland, Baltimore;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Bio Impedance-assisted Monitoring of Chronic Hemodialysis Patients

Conditions:   Chronic Kidney Diseases;   Hemodialysis Complication
Intervention:   Device: NICAS
Sponsor:   Assuta Ashdod Hospital
Recruiting

A Study of People With Type 2 Diabetes Who Have Diseases That Affect the Heart and Blood Vessels. The Study Will Also Look at the Treatment of a Group of These People in Hospitals in Portugal

Condition:   Diabetes Mellitus, Type 2
Intervention:   Other: No treatment given
Sponsor:   Novo Nordisk A/S
Enrolling by invitation

Intervention of Air Pollution and Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Intervention:   Device: mask
Sponsor:   Peking University
Recruiting

Glaucoma Management Optimism for African Americans Living With Glaucoma

Condition:   Glaucoma
Intervention:   Behavioral: Usual Care + Health Promotion Intervention
Sponsor:   University of Alabama at Birmingham
Recruiting

Unmasking Right Ventricular and Pulmonary Derangements With Exercise and Oxygen in Early Stage Cardiopulmonary Diseases

Condition:   Cardiopulmonary Disease
Interventions:   Other: Echocardiography;   Other: Pulmonary Gas Exchange
Sponsor:   Mayo Clinic
Not yet recruiting

Response of the Gut Microbiome and Circulating Metabolome to Diet in Children: Ancillary Study to KIDFIT (NCT03405246)

Conditions:   Gastrointestinal Microbiome;   Metabolome;   Pediatric Obesity;   Dietary Approaches to Stop Hypertension
Interventions:   Behavioral: KIDFIT Healthy;   Behavioral: KIDFIT Safe
Sponsors:   Northwestern University;   American Heart Association;   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation

Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea

Condition:   Obstructive Sleep Apnea
Interventions:   Other: Mild intermittent hypoxia;   Other: Sham protocol;   Other: Continuous positive airway pressure (CPAP)
Sponsors:   Wayne State University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Patient Registry of Posner-Schlossman Syndrome

Condition:   Posner Schlossman Syndrome
Intervention:  
Sponsor:   Peking University
Recruiting

Aortic Calcification and Central Blood Pressure in Patients With Chronic Kidney Disease

Conditions:   Arterial Calcification;   Kidney Diseases;   Coronary Artery Disease;   Aortic Calcification;   Stroke;   Vascular Diseases;   Vascular Calcification
Intervention:  
Sponsor:   Central Jutland Regional Hospital
Not yet recruiting

Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IV Head and Neck Cancer

Conditions:   Head and Neck Squamous Cell Carcinoma;   Stage IVA Oropharyngeal Carcinoma AJCC v7;   Stage IVB Oropharyngeal Carcinoma AJCC v7
Interventions:   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Fluorouracil;   Drug: Hydroxyurea;   Other: Laboratory Biomarker Analysis;   Drug: Paclitaxel;   Other: Placebo;   Radiation: Radiation Therapy;   Drug: Veliparib
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

EMPower: Electronic Media Powering Positive Health Changes in Youth

Conditions:   Hypertension;   Prehypertension;   Overweight;   Obesity;   Hypertrophy, Left Ventricular
Interventions:   Behavioral: Electronic Media Application;   Behavioral: Standard of care education
Sponsors:   Johns Hopkins University;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

Condition:   CAD
Interventions:   Device: MRI scan x 1 Healthy Volunteer;   Device: MRI scan x 2 Healthy Volunteer;   Device: MRI scan x 2 - CAD patients;   Device: MRI scan x 2- non CAD patients
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Safety of Topical Insulin Drops for Open-angle Glaucoma

Condition:   Glaucoma
Interventions:   Drug: Topic insulin (4 units);   Drug: Topic insulin (20 units)
Sponsor:   Centre hospitalier de l'Université de Montréal (CHUM)
Not yet recruiting

Single-dose Study of ANX007 in Participants With Primary Open-angle Glaucoma

Condition:   Open-angle Glaucoma
Intervention:   Biological: ANX007
Sponsor:   Annexon, Inc.
Completed

Clinical and Molecular Studies in Families With Glaucoma and Related Diseases

Condition:   Glaucoma
Intervention:  
Sponsor:   National Eye Institute (NEI)
Completed

Analyses of Interleukin-6, Presepsin and Pentraxin-3 in the Diagnosis and Severity of Late-onset Preeclampsia

Condition:   Preeclampsia
Intervention:   Other: interleukin-6, presepsin and pentraxin-3
Sponsor:   Cengiz Gokcek Women's and Children's Hospital
Completed

Maternal and Neonatal Outcome in Severe Preeclampsia

Condition:   Pre-Eclampsia
Intervention:   Diagnostic Test: Ultrasonography to assess fetus and mother
Sponsors:   Aljazeera Hospital;   Cairo University
Recruiting

Thiol/Disulphide Homeostasis and Preeclampsia

Condition:   Preeclampsia
Intervention:   Other: thiol/disulfide levels
Sponsor:   Cengiz Gokcek Women's and Children's Hospital
Recruiting

Lu-177-DOTATATE (Lutathera) in Therapy of Inoperable Pheochromocytoma/ Paraganglioma

Conditions:   Pheochromocytoma;   Paraganglioma;   Neuroendocrine Tumors;   Neuroendocrine Neoplasms
Interventions:   Drug: Lu-177-DOTATATE;   Drug: Ga-68-DOTATATE;   Drug: F-18-FDG;   Drug: Amino Acid solution
Sponsor:   National Cancer Institute (NCI)
Recruiting

Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study

Conditions:   Glaucoma;   Glaucoma Suspect;   Diabetic Retinopathy;   Ocular Hypertension;   Cataract;   Branch Retinal Vein Occlusion;   Branch Retinal Arterial Occlusion;   Central Retinal Vein Occlusion;   Central Retinal Artery Occlusion;   Epi-retinal Membrane;   Macular Degeneration;   Drusen;   Loss of Vision
Intervention:   Other: Use of patient navigation and social worker
Sponsors:   Wills Eye;   Centers for Disease Control and Prevention;   Westat;   Public Health Management Corporation;   Philadelphia Department of Public Health;   The Health Federation of Philadelphia;   Temple Physicians, Inc.
Active, not recruiting

CTSI Pilot: Improving Adherence to Diabetic Diet

Conditions:   Diabetes Mellitus, Type 2;   Diet, Healthy;   Pre-diabetes
Interventions:   Behavioral: Online - use of online grocery shopping platform;   Behavioral: Default - use of online grocery shopping platform with default shopping carts
Sponsor:   State University of New York at Buffalo
Recruiting

Glaucoma After Congenital And Infantile Cataract Surgery

Conditions:   Glaucoma;   Congenital Cataract
Intervention:  
Sponsor:   Sun Yat-sen University
Recruiting

Safety and Efficacy Study of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-7902-006/E7080-G000-315/LEAP-006)

Condition:   Nonsquamous Non-small Cell Lung Cancer
Interventions:   Biological: Pembrolizumab;   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Pemetrexed;   Drug: Lenvatinib;   Drug: Placebo matching lenvatinib
Sponsors:   Merck Sharp & Dohme Corp.;   Eisai Inc.
Recruiting

Type D Personality and the Compliance for CPAP Therapy and Cardiovascular Complications in OSA.

Condition:   Academic Underachievement Disorder
Intervention:  
Sponsor:   Universitair Ziekenhuis Brussel
Not yet recruiting

Multimodal Ophthalmic Imaging

Conditions:   Retinitis Pigmentosa;   Maculopathy, Age Related;   Macular Dystrophy;   Macular Edema;   Retinal Detachment;   Retinal Degeneration;   Glaucoma;   Vascular Inflammation;   Hypertension;   Stroke;   Diabetes;   Corneal Dystrophy;   Keratoconus;   Dry Eye;   Trauma
Interventions:   Device: High-resolution retinal imaging through adaptive optics;   Device: High-resolution retinal imaging through holographic systems
Sponsor:   Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Recruiting

High Resolution Retina Imaging

Conditions:   Retinitis Pigmentosa;   Maculopathy, Age Related;   Macular Dystrophy;   Macular Edema;   Retinal Degeneration;   Diabetic Retinopathy;   Occlusion Retinal Vein;   Hypertension
Intervention:  
Sponsor:   Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Recruiting

Efficacy and Safety of Endoscopic Variceal Ligation (EVL) Versus EVL Plus Non-selective B-blockers (NSBB) For Prevention of Variceal Rebleed and Non-bleed Related Complications in Patients With Advanced Cirrhosis

Condition:   Advanced Cirrhosis
Interventions:   Procedure: Endoscopic Variceal Ligation;   Drug: Non selective beta blocker;   Other: Placebo
Sponsor:   Institute of Liver and Biliary Sciences, India
Withdrawn

Patiromer for the Management of Hyperkalemia in Subjects Receiving RAASi Medications for the Treatment of Heart Failure (DIAMOND)

Condition:   Hyperkalemia
Interventions:   Drug: Patiromer;   Drug: Placebos
Sponsors:   Relypsa, Inc.;   Vifor Pharma
Recruiting

UrApp for Childhood Nephrotic Syndrome Management (Incident Cohort)

Condition:   Idiopathic Nephrotic Syndrome
Interventions:   Behavioral: Standard of Care;   Behavioral: UrApp
Sponsors:   Emory University;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Obstructive Sleep Apnea Among Somali-Americans

Condition:   Obstructive Sleep Apnea
Intervention:  
Sponsor:   Mayo Clinic
Recruiting

Advanced Glaucoma Progression Study

Conditions:   Primary Open Angle Glaucoma;   Pseudoexfoliative Glaucoma;   Chronic Angle Closure Glaucoma
Intervention:  
Sponsors:   University of California, Los Angeles;   National Eye Institute (NEI)
Active, not recruiting

KRX-0502 (Ferric Citrate) in Subjects With NDD-CKD and IDA (The COMPASS Trial)

Conditions:   Chronic Kidney Diseases;   Iron Deficiency Anemia
Intervention:   Drug: KRX-0502
Sponsor:   Keryx Biopharmaceuticals
Completed

Supplemental Calcium in Overweight People

Condition:   Obesity
Interventions:   Drug: Calcium supplement;   Drug: Placebo
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   Office of Dietary Supplements (ODS)
Completed

Trial to Evaluate Anticoagulation Therapy in Hemodialysis Patients With Atrial Fibrillation

Conditions:   Atrial Fibrillation;   End Stage Renal Disease
Interventions:   Drug: apixaban;   Drug: warfarin
Sponsors:   Christopher Granger, MD;   Bristol-Myers Squibb
Completed

The Use of Eculizumab in HELLP Syndrome

Conditions:   HELLP Syndrome (HELLP), Third Trimester;   Complement Abnormality;   Morbidity;Newborn;   Maternal Injury;   Preeclampsia Severe
Intervention:   Drug: Eculizumab
Sponsor:   Johns Hopkins University
Not yet recruiting

Surgical or Medical Treatment

Conditions:   Diabetes Mellitus, Type 2;   Pediatric Obesity;   Bariatric Surgery Candidate
Interventions:   Procedure: Bariatric Surgery;   Drug: Advanced Medical Therapy
Sponsors:   Children's Hospital Medical Center, Cincinnati;   Children's Hospital Colorado
Not yet recruiting

Partnering With WIC to Prevent Excessive Weight Gain in Pregnancy

Conditions:   Obesity;   Overweight;   Pregnancy Related
Intervention:   Behavioral: Antenatal Obesity Treatment (AO)
Sponsors:   Temple University;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Metformin as RenoProtector of Progressive Kidney Disease

Condition:   Chronic Kidney Diseases
Interventions:   Drug: Metformin Hydrochloride;   Drug: Placebo Oral Tablet
Sponsor:   Universiteit Antwerpen
Not yet recruiting

The Combined Portfolio Diet and Exercise Study

Conditions:   Cardiovascular Diseases;   Hypercholesterolemia;   Type 2 Diabetes;   Metabolic Syndrome
Interventions:   Behavioral: Portfolio diet and structured exercise;   Behavioral: DASH-like diet and structured exercise;   Behavioral: Portfolio diet and routine exercise;   Behavioral: DASH-like diet and routine exercise
Sponsors:   St. Michael's Hospital, Toronto;   Canadian Institutes of Health Research (CIHR);   University of Toronto;   Laval University;   University of Manitoba;   University of British Columbia
Recruiting

Efficacy and Safety of Selonsertib in Participants With Moderate to Advanced Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: SEL;   Drug: Placebo
Sponsor:   Gilead Sciences
Recruiting

Vinblastine/Prednisone Versus Single Therapy With Cytarabine for Langerhans Cell Histiocytosis (LCH)

Condition:   Langerhans Cell Histiocytosis
Interventions:   Drug: Cytarabine;   Drug: Vinblastine/prednisone
Sponsors:   Baylor College of Medicine;   Texas Children's Hospital
Recruiting

A Study to Assess the Efficacy and Safety of Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)

Condition:   Duchenne Muscular Dystrophy
Interventions:   Drug: Vamorolone;   Drug: Prednisone;   Other: Placebo
Sponsors:   ReveraGen BioPharma, Inc.;   European Union;   Cooperative International Neuromuscular Research Group;   Newcastle University;   University of Pittsburgh
Recruiting

Research Study Comparing Insulin Degludec to Insulin Detemir, Together With Insulin Aspart, in Pregnant Women With Type 1 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 1
Interventions:   Drug: Insulin degludec;   Drug: Insulin Aspart;   Drug: Insulin detemir
Sponsor:   Novo Nordisk A/S
Recruiting

DISCOVER Global Registry

Condition:   Type 2 Diabetes
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Gastric Slow Wave and Autonomic Nervous Function in Cirrhotic Patients With Esophageal Varices After Ligation-A Clinical Research

Condition:   Esophageal Varices in Cirrhosis of the Liver
Interventions:   Diagnostic Test: Electrogastrogram(EGG);   Diagnostic Test: Heart Rate Variability(HRV)
Sponsor:   The First Affiliated Hospital with Nanjing Medical University
Completed

Individualized Physical Exercise Training and Enhanced Protein Intake During Rehabilitation of Elderly Citizens

Condition:   Rehabilitation
Interventions:   Other: Usual Care;   Other: Usual Care with Protein Supplementation;   Other: Individualized Physical Exercise Training with Protein Supplementation
Sponsors:   University College Absalon;   University of Southern Denmark;   Sundhed og Træning, Slagelse Municipality;   Arla Foods;   Danish Council for Independent Research;   Association of Danish Physiotherapists
Not yet recruiting

Lifestyle Intervention for Women With Recent Pre-eclampsia or Gestational Diabetes Mellitus ('Mom's Healthy Heart')

Conditions:   Pre-Eclampsia;   Gestational Diabetes
Intervention:   Behavioral: Web-based lifestyle intervention
Sponsors:   Norwegian University of Science and Technology;   Harvard Medical School;   University of Oslo
Not yet recruiting

End-stage Renal Disease (ESRD) Pilot Study

Condition:   Renal Dialysis
Interventions:   Drug: BAY1213790;   Drug: 0.9% sodium chloride solution
Sponsor:   Bayer
Recruiting

INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure

Conditions:   Heart Failure;   Myocardial Infarction
Interventions:   Biological: High Dose Trivalent Influenza Vaccine;   Biological: Standard Dose Quadrivalent Influenza Vaccine
Sponsors:   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI);   University of Wisconsin, Madison;   University of Toronto;   Boston VA Research Institute, Inc.;   Patient-Centered Outcomes Research Institute
Active, not recruiting

International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Coronary Artery Disease;   Heart Diseases;   Myocardial Ischemia
Interventions:   Procedure: cardiac catheterization;   Procedure: coronary artery bypass graft surgery;   Procedure: percutaneous coronary intervention;   Behavioral: Lifestyle;   Drug: Medication
Sponsors:   NYU Langone Health;   New York University;   Stanford University;   National Heart, Lung, and Blood Institute (NHLBI);   Albany Stratton VA Medical Center;   Cedars-Sinai Medical Center;   Columbia University;   Duke University;   East Carolina University;   Emory University;   Harvard University;   Massachusetts General Hospital;   Montreal Heart Institute;   University of British Columbia;   University of Missouri, Kansas City;   Vanderbilt University
Active, not recruiting

EMPA-KIDNEY (The Study of Heart and Kidney Protection With Empagliflozin)

Condition:   Chronic Kidney Disease
Interventions:   Drug: Empagliflozin;   Drug: Matching placebo
Sponsors:   Boehringer Ingelheim;   Medical Research Council Population Health Research Unit, CTSU, University of Oxford (academic lead);   Eli Lilly and Company
Recruiting

EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)

Condition:   Heart Failure
Interventions:   Drug: Empagliflozin;   Drug: Placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting

EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)

Condition:   Heart Failure
Interventions:   Drug: Empagliflozin;   Drug: Placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting

Comparative Imaging Assessment of Valvular Heart Disease

Conditions:   Valve Heart Disease;   Aortic Stenosis;   Aortic Regurgitation
Interventions:   Diagnostic Test: MRI with strain measurement;   Diagnostic Test: Echocardiography
Sponsor:   The Cleveland Clinic
Recruiting

Activity Coaching in Patients Post Lung Transplantation

Condition:   Lung Transplantation
Interventions:   Behavioral: Multi-component physical activity tele coaching intervention;   Behavioral: Light coaching intervention
Sponsor:   KU Leuven
Not yet recruiting

Open-label Treatment in Cushing's Syndrome

Conditions:   Cushing Syndrome;   Cushing Disease
Intervention:   Drug: Levoketoconazole
Sponsor:   Cortendo AB
Recruiting

Efficacy and Safety of Lucerastat Oral Monotherapy in Adult Subjects With Fabry Disease

Condition:   Fabry Disease
Interventions:   Drug: Lucerastat;   Drug: Placebo
Sponsor:   Idorsia Pharmaceuticals Ltd.
Recruiting

Muscular Respiratory Involvement and Systemic Sclerosis

Conditions:   Systemic Sclerosis;   Diaphragm Defect;   Respiratory Insufficiency;   Pulmonary Function Test;   Diaphragmatic Electromyography;   Muscular Weakness
Intervention:   Diagnostic Test: Pulmonary function test
Sponsor:   Poitiers University Hospital
Not yet recruiting

Post-Authorisation Safety Cohort Observation of RetacritTM (Epoetin Zeta) Administered Subcutaneously for the Treatment of Renal Anaemia

Conditions:   Renal Anemia;   Pregnancy;   Lactation
Intervention:  
Sponsors:   Pfizer;   Hospira, now a wholly owned subsidiary of Pfizer
Active, not recruiting

Study of Safety, Reactogenicity and Immunogenicity of GlaxoSmithKline's (GSK)Respiratory Syncytial Virus (RSV)Maternal Unadjuvanted Vaccine in Healthy Pregnant Women (Aged 18 to 40 Years) and Their Infants

Condition:   Respiratory Syncytial Virus Infections
Interventions:   Biological: RSVPreF3 formulation 2;   Biological: RSVPreF3 formulation 3;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Not yet recruiting

Prospective Study of the Diagnostic and Therapeutic Management of Congenital Glaucoma in France

Condition:   Congenital Glaucoma
Intervention:   Procedure: TRABECULOTOMY
Sponsor:   University Hospital, Lille
Recruiting

Dietary Nitrate Intake in Vegetarians and Omnivores

Condition:   Blood Pressure
Interventions:   Other: Placebo mouthwash;   Other: Chlorhexidine mouthwash
Sponsors:   University of Plymouth;   University of the West of Scotland
Completed

Endoscopic Gastric Tubulization

Condition:   Morbid Obesity
Intervention:   Procedure: Endoscopic gastric tubulization
Sponsor:   IHU Strasbourg
Recruiting

Tacrolimus After rATG and Infliximab Induction Immunosuppression (RIMINI)

Condition:   Renal Transplant Rejection
Intervention:   Drug: Antithymocyte Immunoglobulin (Rabbit)
Sponsors:   Prof. Dr. Petra Reinke;   Institut Klinické a Experimentální Medicíny
Recruiting

Effects of an Aquatic Physical Exercise Program on Glycaemic Control and Perinatal Outcomes of Gestational Diabetes: Study Protocol for a Randomized Controlled Trial

Condition:   Diabetes, Gestational
Intervention:   Other: Aquatic exercise
Sponsors:   Professor Fernando Figueira Integral Medicine Institute;   Conselho Nacional de Desenvolvimento Científico e Tecnológico;   Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco
Completed

Efficacy and Tolerance Comparison Between Subconjunctival Injection of Triamcinolone and Intravitreal Implant of Dexamethasone for the Treatment of Inflammatory Macular Edema

Condition:   Inflammatory Macular Edema
Interventions:   Drug: Dexamethasone;   Drug: Triamcinolone
Sponsor:   Nantes University Hospital
Recruiting

Lipid Profile and Diabetes Mellitus in People With HIV

Conditions:   HIV Infections;   Dyslipidemias;   Diabetes Mellitus;   Cardiovascular Risk Factor
Intervention:  
Sponsors:   Igor Grabovac;   Merck Gesellschaft mbH, Austria
Not yet recruiting

Pre-FRONTal Brain STability, Key for Action Against Disability in AGing

Conditions:   Cognitive Impairment;   Motoric Cognitive Risk Syndrome
Interventions:   Behavioral: Physical exercise (PE);   Device: Transcranial current stimulation (tCS);   Other: Control
Sponsors:   Parc Sanitari Pere Virgili;   Institute for Photonic Sciences - ICFO;   Hospital de la Ribera;   Fundacio Ictus Malaltia Vascular;   Institut Català de la Salut;   Institut de Recerca Vall d'Hebron
Not yet recruiting

Registry for Real-world Experience of Catheter Ablation for Symptomatic Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Intervention:   Device: Catheter ablation with novel radiofrequency technologies
Sponsors:   Jose Osorio;   Biosense Webster, Inc.
Enrolling by invitation

EUS-guided Combined Therapy Versus Beta Blocker Therapy in Primary Prophylaxis o GOV II and IGV I

Conditions:   Gastric Varix;   Cirrhosis;   GastroIntestinal Bleeding
Interventions:   Procedure: Coils + Cyanoacrylate Group + beta-blocker;   Drug: beta blocker therapy
Sponsor:   Instituto Ecuatoriano de Enfermedades Digestivas
Recruiting