High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Cardiac MRI in Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Device: Magnetic resonance Imaging
Sponsor:   University of California, San Francisco
Not yet recruiting - verified June 2015

Efficacy and Safety of Olmesartan Associated With Chlorthalidone Versus Losartan Associated With Hydrochlorothiazide (Hyzaar®) in Essential Hypertension Control

Condition:   Arterial Hypertension
Interventions:   Drug: Olmesartan medoxomil + chlorthalidone;   Drug: Olmesartan medoxomil + chlorthalidone;   Drug: Losartan + hydrochlorothiazide (Hyzaar ®)
Sponsor:   EMS
Not yet recruiting - verified June 2015

Effect of Pharmacologic Interaction Between ERAs and PDE-5 Inhibitors on Medication Serum Levels and Clinical Disease Status in Patients With PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Other: no intervention, only observation of different groups
Sponsor:   Heidelberg University
Recruiting - verified June 2015

We Talk About Our Hypertension

Condition:   Hypertension
Intervention:   Behavioral: Storytelling
Sponsors:   Institute of Population, Health and Development, Vietnam;   University of Massachusetts, Worcester
Not yet recruiting - verified June 2015

Sham Controlled Study of Renal Denervation for Untreated Stage I and II Hypertension

Condition:   Hypertension
Interventions:   Device: Ultrasound;   Device: Sham Ultrasound
Sponsor:   Kona Medical Inc.
Not yet recruiting - verified June 2015

Early Sleeve Gastrectomy In New Onset Diabetic Obese Patients

Condition:   Type 2 Diabetes Mellitus
Interventions:   Procedure: Laparoscopic Sleeve Gastrectomy plus conventional medical therapy;   Drug: Conventional medical therapy
Sponsors:   Azienda Ospedaliera Santa Maria, Terni, Italy;   Ethicon Endo-Surgery
Not yet recruiting - verified June 2015

IRIS Registry: Intelligent Research in Sight Registry

Condition:   Eye Diseases
Intervention:   Procedure: Ophthalmology
Sponsor:   American Academy of Ophthalmology
Recruiting - verified June 2015

3D CT Guidance for Transjugular Intrahepatic Portosystemic Shunt Creation

Condition:   Portal Hypertension
Interventions:   Device: CT-image guidance;   Drug: CO2 portograms guidance
Sponsor:   West China Hospital
Not yet recruiting - verified June 2015

Effect of Rosuvastatin on Coronary Flow Reserve in Hypertensive Patients With Cardiovascular Risk

Condition:   Hypertension
Interventions:   Drug: Rosuvastatin;   Behavioral: Life style modification
Sponsors:   Asan Medical Center;   Dong-A ST Co., Ltd.
Not yet recruiting - verified June 2015

The Dutch National Renal Denervation Registry

Condition:   Hypertension
Intervention:   Procedure: Renal denervation
Sponsors:   UMC Utrecht;   Dutch Kidney Foundation
Recruiting - verified June 2015

Using Ultrasound Elastography to Predict Development of SOS

Conditions:   Sinusoidal Obstruction Syndrome;   Complications of Bone Marrow Transplant
Intervention:   Procedure: shear wave ultrasound elastography
Sponsor:   Children's Mercy Hospital Kansas City
Not yet recruiting - verified June 2015

Quality of Life in Children Glaucoma and Cataract

Conditions:   Paediatrics With Cataracts;   Paediatrics With Glaucoma
Intervention:   Other: Quality of Life questionnaire
Sponsor:   Moorfields Eye Hospital NHS Foundation Trust
Recruiting - verified June 2015

Real Evidence of Anticoagulation Treatment in Non-valvular Atrial Fibrillation in Germany and the UK: REACT-AF2

Condition:   Non-valvular Atrial Fibrillation
Sponsors:   Bristol-Myers Squibb;   IMS Health;   Oxon Epidemiology
Active, not recruiting - verified June 2015

Is it Fair to Use Antibiotics After Laparoscopic Cholecystectomy for the Patients With Acutely Inflamed Gallbladder?

Condition:   Acute Cholecystitis
Interventions:   Drug: Cephalosporin;   Drug: Placebo
Sponsors:   Seoul St. Mary's Hospital;   Incheon St.Mary's Hospital;   The Catholic University of Korea
Recruiting - verified June 2015

Promoting Self-Management in Low Income African Americans Living With Hypertension

Condition:   Hypertension
Intervention:   Behavioral: Ecological Nurse Case Management
Sponsors:   Bev Zabler;   Medical College of Wisconsin
Recruiting - verified June 2015

Effects of Polyphenols Found in Pomegranate and Bonolive on Postprandial Blood Glucose in Vivo.

Condition:   Hyperglycaemia
Interventions:   Other: Control (109 g white bread);   Dietary Supplement: Dose 1 (pomegranate or bonolive);   Dietary Supplement: Dose 2 (pomegranate or bonolive)
Sponsor:   University of Leeds
Recruiting - verified June 2015

Home Electronic Monitoring of Chronic Heart Failure

Condition:   Chronic Heart Failure
Intervention:   Device: telemonitoring of weight, pulse and blood pressure
Sponsors:   Centre Hospitalier Universitaire de Besancon;   AG2R La Mondiale;   IMRI;   AFPEC;   H2AD;   Pôle des Microtechniques de Besançon
Not yet recruiting - verified June 2015

Congenital Malformations and Maternal Use of Anti-hypertensive Medication in the United Kingdom

Condition:   Hypertension
Sponsor:   AstraZeneca
Completed - verified July 2015

Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension

Conditions:   Liver Diseases;   Portal Hypertension
Intervention:   Drug: SHAPE measurement (Sonazoid ultrasoud contrast agent)
Sponsors:   Thomas Jefferson University;   University of Pennsylvania;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified July 2015

Study to Assess Acute Vasodilation Response of Inhaled Nitric Oxide

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Inhaled Nitric Oxide
Sponsor:   Geno LLC
Recruiting - verified June 2015

SIMBRINZA® Suspension BID as an Adjunctive to Prostaglandin Analogue (PGA)

Conditions:   Open-Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Brinzolamide 1%/brimonidine 0.2% tartrate ophthalmic suspension;   Drug: Brinz/brim vehicle;   Drug: Prostaglandin analogue
Sponsor:   Alcon Research
Not yet recruiting - verified June 2015

A Prospective, Observational, Multicenter Study of Patients Following Initiation of a New Course of Treatment for Overactive Bladder (OAB)

Conditions:   Overactive Bladder;   Urinary Bladder Overactive;   Urinary Bladder Diseases;   Urologic Diseases
Interventions:   Drug: mirabegron;   Drug: antimuscarinic medication
Sponsor:   Astellas Scientific & Medical Affairs, Inc.
Recruiting - verified July 2015

Comparison of Single and Combination Diuretics in Low-Renin Hypertension

Condition:   Hypertension
Interventions:   Drug: Hydrochlorthiazide;   Drug: Amiloride;   Drug: Hydrochlorthiazide and Amiloride
Sponsors:   University of Cambridge;   University of Leicester;   University of Dundee;   University of Glasgow;   University of Edinburgh;   Imperial College London;   Barts & The London NHS Trust;   King's College London;   University of Birmingham
Active, not recruiting - verified July 2015

Maternal Hypertriglyceridaemia Study

Condition:   Metabolic Syndrome X
Intervention:   Procedure: Blood sampling
Sponsor:   University of Malaya
Recruiting - verified June 2015

Patient and Provider Assessment of Lipid Management Registry

Conditions:   Hyperlipidemia;   Hypercholesterolemia;   Cardiovascular Disease;   Diabetes;   Chronic Kidney Disease (CKD);   Hypertension;   Smoking;   Myocardial Infarction (MI);   Unstable Angina;   Angina;   Coronary Artery Disease (CAD);   Stroke;   Transient Ischemic Attack (TIA);   Carotid Stenosis;   Peripheral Arterial Disease;   Atherosclerosis;   Claudication
Sponsors:   Duke University;   Regeneron Pharmaceuticals;   Sanofi
Recruiting - verified June 2015

Iloprost for Bridging to Heart Transplantation in PH

Conditions:   Chronic Left Ventricular Failure;   Pulmonary Hypertension
Interventions:   Drug: Inhaled Iloprost;   Drug: Placebo
Sponsors:   Heidelberg University;   Bayer
Withdrawn - verified June 2015

Primary Care Clinical Practice Elements and Improving Overweight Children's Weight Status

Conditions:   Overweight;   Childhood Obesity
Interventions:   Other: BMI screened/interpreted;   Other: Provider addressed weight and weight-related disease risk;   Other: Provider reassessed high weight status;   Other: No weight-status assessment
Sponsors:   University of Texas Southwestern Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified July 2015

Phase III Trial BI 695502 Plus Chemotherapy vs. Avastin® Plus Chemotherapy in Patients With Lung Cancer

Condition:   Carcinoma, Non-Small-Cell Lung
Interventions:   Drug: Chemotherapy;   Drug: BI 695502;   Drug: bevacizumab;   Drug: Chemotherapy
Sponsor:   Boehringer Ingelheim
Not yet recruiting - verified June 2015

Hispanic Secondary Stroke Prevention Initiative

Condition:   Stroke
Interventions:   Behavioral: Community Health Worker (CHW) home visits, coaching phone calls, group sessions .;   Other: usual care and health education brochures every 4 months.
Sponsors:   University of Miami;   National Institute on Minority Health and Health Disparities (NIMHD)
Recruiting - verified July 2015

Dexmedetomidine for Postoperative Analgesia After Bariatric Surgery

Conditions:   Obesity;   Sleep Apnea;   Diabetes;   Hypertension
Interventions:   Drug: Dexmedetomidine;   Drug: Morphine
Sponsor:   American University of Beirut Medical Center
Recruiting - verified June 2015

Developing an Integrated System Approach for the Management of Hypertension: A Pilot Study

Condition:   Hypertension
Intervention:   Other: Referral System
Sponsor:   Aga Khan University
Completed - verified June 2015

Telemonitoring System Study in Participants With Type 2 Diabetes Mellitus (MK-0000-347)

Condition:   Type 2 Diabetes Mellitus
Intervention:   Device: Home telehealth system
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified June 2015

MOTION, Measuring Outcomes in Treatment Naive Patients

Condition:   Pulmonary
Intervention:   Drug: Riociguat (Adempas,BAY63-2521)
Sponsor:   Bayer
Recruiting - verified June 2015

Perioperative Blood Pressures and Chronic Hypertension

Condition:   Hypertension
Sponsors:   Yale University;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified May 2014

Culturing TM Cells From Primary Open-angle Glaucoma Patient Biopsies

Condition:   Glaucoma
Sponsor:   University of South Florida
Recruiting - verified June 2015

Haemodynamic Effects of Apelin Agonists and Antagonists in Man in COPD With Raised Pulmonary Artery Pressures

Conditions:   COPD;   Pulmonary Hypertension
Interventions:   Procedure: Forearm plethysmography;   Procedure: Haemodynamic studies
Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   Wellcome Trust;   University of Cambridge
Completed - verified January 2015

An RCT of Bariatric Surgery vs a Community Weight Loss Programme for the Sustained Treatment of IIH

Condition:   Idiopathic Intracranial Hypertension
Interventions:   Procedure: Bariatric surgery;   Behavioral: Dietetic intervention
Sponsors:   University of Birmingham;   National Institute for Health Research, United Kingdom
Recruiting - verified June 2015

Albuterol and Dynamic Hyperinflation in Idiopathic Pulmonary Arterial Hypertension

Condition:   Idiopathic Pulmonary Arterial Hypertension.
Interventions:   Drug: Albuterol.;   Drug: Normal saline placebo
Sponsor:   American Medical Association Foundation
Recruiting - verified June 2015

ADPKD Cohort Study

Condition:   Autosomal Dominant Polycystic Kidney Disease
Sponsors:   Emory University;   PKD Foundation
Completed - verified June 2015

Pharmacokinetics, Safety and Efficacy Study of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia

Condition:   Preeclampsia
Intervention:   Biological: Recombinant human antithrombin (ATryn)
Sponsor:   rEVO Biologics
Recruiting - verified June 2015

Cardiovascular Disease Risk Factors Prevalence Among Bayer's Employees in São Paulo, Brazil

Condition:   Occupational Health
Intervention:   Behavioral: Examination and survey
Sponsor:   Bayer
Active, not recruiting - verified July 2015

Information Systems-enabled Outreach Program for Adverse Drug Events

Condition:   Adverse Drug Events
Intervention:   Other: ISTOP-ADE
Sponsors:   Ottawa Hospital Research Institute;   Canadian Institutes of Health Research  (CIHR);   McGill University
Not yet recruiting - verified June 2015

UAB Center of Research Translation (CORT) Project 2: The Effects of Urate Lowing Therapy (ULT) in Inflammation, Endothelial Function, and Blood Pressure

Conditions:   Pre-hypertension;   JNC 7 Stage I Hypertension
Interventions:   Drug: Allopurinol;   Drug: Placebo
Sponsors:   University of Alabama at Birmingham;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified June 2015

Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension.

Condition:   Idiopathic Intracranial Hypertension
Intervention:   Drug: AZD4017
Sponsor:   University of Birmingham
Recruiting - verified June 2015

Telmisartan vs. Perindopril in Hypertensive Mild-Moderate Alzheimer's Disease Patients

Conditions:   Alzheimer's Disease;   Hypertension
Interventions:   Drug: Perindopril;   Drug: Telmisartan
Sponsors:   Dr. Sandra E Black;   Alzheimer’s Drug Discovery Foundation
Recruiting - verified June 2015

Primary Hyperaldosteronism and Ischemia-reperfusion Injury

Condition:   Primary Hyperaldosteronism
Intervention:   Procedure: forearm ischemia and reperfusion
Sponsor:   Radboud University
Enrolling by invitation - verified June 2015

Trans-pulmonary Biomarkers in Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Sponsors:   Vanderbilt University;   Gilead Sciences
Recruiting - verified June 2015

GLORIA-AF Registry Program (Phase II/III)

Conditions:   Stroke;   Atrial Fibrillation
Sponsor:   Boehringer Ingelheim
Recruiting - verified July 2015

Beraprost-314d Added-on to Tyvaso® (BEAT)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Beraprost Sodium 314d Modified Release Tablets;   Drug: Placebo
Sponsor:   Lung Biotechnology PBC
Recruiting - verified June 2015

Optimum Treatment for Drug-Resistant Hypertension

Condition:   Hypertension, Resistant to Conventional Therapy
Interventions:   Drug: Spironolactone;   Drug: Bisoprolol;   Drug: Doxazosin;   Drug: Placebo
Sponsors:   University of Cambridge;   British Heart Foundation
Active, not recruiting - verified July 2015

Study of Microcirculatory Effects of Bevacizumab in Patients Treated for Metastatic Colon Cancer or Glioblastoma

Conditions:   Metastatic Colorectal Cancer;   Glioblastoma;   Bevacizumab;   Capillaroscopy
Interventions:   Other: capillaroscopy;   Other: blood pressure measurement
Sponsor:   Centre Georges Francois Leclerc
Recruiting - verified June 2015

Comparison of Ultrafast Echo With Echotracking

Conditions:   Essential Untreated Hypertension;   Healthy Volunteers
Sponsor:   French Cardiology Society
Active, not recruiting - verified May 2015

Free DNA and Nucleosome Concentrations in Pathological Pregnancies

Conditions:   Pregnancy;   Venous Thrombosis;   Pulmonary Embolism;   Hypertension, Pregnancy-Induced;   Eclampsia;   HELLP Syndrome;   Pre-Eclampsia;   Fetal Death;   Placental Insufficiency
Interventions:   Biological: Bloodwork, baseline;   Biological: Blood work, Months 1 & 2;   Biological: Bloodwork, Months -1 to -6
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Recruiting - verified June 2015

Weight Loss and Maintenance for Individuals With Intellectual Developmental Disabilities (IDD)

Condition:   Weight Loss
Interventions:   Dietary Supplement: Modified Stop Light Diet (SLDm);   Dietary Supplement: Recommended Care Diet
Sponsor:   Joseph Donnelly
Active, not recruiting - verified June 2015

Prospective Characterization of the Heart, Aorta and Blood Pressure in Turner Syndrome. Association With Aortic Dissection.

Conditions:   Turner Syndrome;   Aortic Aneurysm;   Ischemic Heart Disease;   Hypertension;   Congenital Heart Defect
Sponsor:   University of Aarhus
Recruiting - verified June 2015

Lipophilic Micronutrients, Adipokines and Gestational Diabetes Mellitus

Condition:   Gestational Diabetes Mellitus
Intervention:   Other: blood sample
Sponsor:   Assistance Publique Hopitaux De Marseille
Recruiting - verified July 2015

X-chromosome Inactivation, Epigenetics and the Transcriptome

Conditions:   Turner Syndrome;   Klinefelter Syndrome;   Triple X Syndrome;   47 XYY Syndrome;   Aortic Aneurysm
Sponsors:   University of Aarhus;   Lundbeck Foundation;   The Korning Foundation Denmark;   AP Moeller Foundation
Active, not recruiting - verified June 2015

Effect of Obstructive Sleep Apnea Syndrome on Insulin Sensitivity and Cardiovascular Risk in PCOS Adolescents

Conditions:   Obstructive Sleep Apnea Syndrome;   Polycystic Ovary Syndrome;   Sleep Apnea
Intervention:   Device: Nasal Continuous positive airway pressure (CPAP)
Sponsor:   Albert Einstein College of Medicine of Yeshiva University
Completed - verified June 2015

Fibrosis a New Pathological Actor in Adipose Tissue

Conditions:   Obesity;   Metabolic Diseases;   Fibrosis;   Body Weight
Intervention:   Procedure: biopsy
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting - verified April 2015

Imatinib and Carvedilol for High Blood Pressure in the Lungs in Adults With Sickle Cell Disease

Condition:   Pulmonary Hypertension
Interventions:   Drug: Carvedilol;   Drug: Imatinib
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Withdrawn - verified December 2012

A Study of RO5093151 in Patients With Ocular Hypertension Or Open Angle Glaucoma

Condition:   Hypertension, Glaucoma, Open-Angle
Interventions:   Drug: Placebo;   Drug: RO5093151
Sponsor:   Hoffmann-La Roche
Completed - verified July 2015

Mifepristone for Metabolic Syndrome

Conditions:   Endocrine Disease;   Diabetes
Intervention:   Drug: Mifepristone
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified March 2015

Inhaled Iloprost in the Treatment of Patients With Pulmonary Hypertension up to 4 Years

Condition:   Pulmonary Hypertension
Intervention:   Drug: Ventavis inhaled (Iloprost, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified June 2015

Psoriasis Inflammation and Systemic Co Morbidities

Condition:   Psoriasis
Sponsors:   Rockefeller University;   Weill Medical College of Cornell University
Active, not recruiting - verified June 2015

A Multiple Dose Study of MK3614 (3614-002)

Condition:   Hypertension
Interventions:   Drug: MK3614;   Drug: Comparator: MK3614 .75 mg 1st;   Drug: Comparator: MK3614 titrating down dose;   Drug: Comparator: MK3614 multiple rising dose;   Drug: Comparator: Placebo Panel A;   Drug: Comparator: Placebo Panel B-C;   Drug: Comparator: Placebo Panel D;   Drug: Comparator: Placebo Panel E
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified June 2015

A Single Dose Study of MK8266 (8266-001)

Condition:   Hypertension
Interventions:   Drug: MK8266;   Drug: Placebo
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified June 2015

A Clinical Trial of IntensiVE Dialysis

Conditions:   Renal Replacement Therapy;   Renal Dialysis;   End Stage Kidney Disease;   End Stage Renal Disease;   Uremia
Intervention:   Procedure: haemodialysis
Sponsors:   The George Institute;   National Health and Medical Research Council, Australia;   Baxter Healthcare Corporation
Completed - verified June 2013

Promoting Healthy Weight With 'Stability Skills First'

Condition:   Obesity
Intervention:   Behavioral: Behavioral weight-loss/lifestyle interventions
Sponsors:   Stanford University;   National Cancer Institute (NCI)
Completed - verified June 2015

Long-term Clinical Study Evaluating the Safety and Efficacy of Dexmedetomidine in ICU Subjects

Condition:   Sedation
Intervention:   Drug: Dexmedetomidine
Sponsors:   Hospira, Inc.;   Maruishi Pharmaceutical
Completed - verified June 2015

Cardiology Biobank Registry

Condition:   Cardiovascular Disease
Sponsor:   Emory University
Recruiting - verified June 2015

Effectiveness of Nigella Sativa (Kalonji) Seed in Dyslipidemia

Conditions:   Hypercholesterolemia;   Hypertension;   Diabetes Mellitus;   Metabolic Syndrome X
Intervention:   Drug: Nigella sativa seed
Sponsor:   Aga Khan University
Completed - verified April 2007

Comparing Efficacy and Safety of Steroid Withdrawal With Tacrolimus and MMF With Induction in Children After Kidney Transplantation

Condition:   Kidney Transplantation
Interventions:   Drug: tacrolimus;   Drug: mycophenolate   mofetil;   Drug: daclizumab;   Drug: steroids
Sponsor:   Astellas Pharma Inc
Completed - verified June 2015

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