High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Improving Hypertension Detection and Control Through a Hypertension Certification Program Based Upon the Hypertension Canada Guidelines

Condition:   Hypertension
Intervention:   Behavioral: Hypertension Canada Professional Designation Program: HC-PDP
Sponsors:   University of Alberta;   Hypertension Canada
Not yet recruiting

Remote Surveillance of Postpartum Hypertension

Condition:   Hypertension in Pregnancy
Intervention:   Other: Remote (text based) surveillance
Sponsor:   University of Pennsylvania
Completed

Implementing Hypertension Screening Guidelines in Primary Care

Conditions:   Hypertension,Essential;   White Coat Hypertension
Intervention:   Behavioral: Multifaceted Implementation Strategy
Sponsors:   Columbia University;   Agency for Healthcare Research and Quality (AHRQ)
Recruiting

Evaluating Control of Hypertension - Effect of Social Determinants

Condition:   Hypertension
Intervention:   Other: Medicaid Expansion
Sponsors:   Oregon Health and Science University;   Ochin, Inc.;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI);   Health Choice Network;   Fenway Community Health
Active, not recruiting

Pediatric Pulmonary Hypertension Network (PPHNet) Informatics Registry

Conditions:   Pulmonary Vascular Disease;   Pulmonary Arterial Hypertension
Intervention:  
Sponsors:   University of Colorado, Denver;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Inhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension

Conditions:   Sarcoidosis;   Precapillary Pulmonary Hypertension;   Interstitial Lung Disease
Intervention:   Drug: Inhaled Treprostinil
Sponsors:   University of Florida;   United Therapeutics
Not yet recruiting

Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension

Conditions:   Sickle Cell Anemia;   Pulmonary Hypertension
Interventions:   Drug: Nitric Oxide;   Device: INO Pulse - NO Delivery System
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   Mallinckrodt
Completed

Hemodynamic Parameters Changes in the Course of Hemodialysis Sessions in Patients With Intradialytic Hypertension

Condition:   Intradialytic Hypertension
Intervention:  
Sponsor:   Western Galilee Hospital-Nahariya
Completed

Riociguat in Children With Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsors:   Bayer;   Merck Sharp & Dohme Corp.
Recruiting

Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer

Conditions:   Breast Carcinoma;   Hypertension
Intervention:   Other: Laboratory Biomarker Analysis
Sponsor:   National Cancer Institute (NCI)
Recruiting

GAstric Bypass to Treat obEse Patients With steAdy hYpertension

Conditions:   Systemic Hypertension;   Obesity
Interventions:   Procedure: Laparoscopic Roux-en-Y gastric bypass (LRYGB);   Other: Clinical treatment
Sponsors:   Hospital do Coracao;   Ethicon Endo-Surgery
Active, not recruiting

Compassionate Use of Beraprost Sodium 314d Modified Release for Patients With Pulmonary Arterial Hypertension (PAH)

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: BPS-314d-MR
Sponsors:   Los Angeles Biomedical Research Institute;   Lung Biotechnology PBC
Completed

Hypertension Chronobiome

Condition:   Hypertension
Intervention:   Other: Ambulatory blood pressure measurements
Sponsor:   University of Pennsylvania
Recruiting

BREMEN Eye Drops Versus Combigan for Open-angle Glaucoma or Intraocular Hypertension

Conditions:   Ocular Hypertension;   Primary Open-angle Glaucoma
Interventions:   Drug: BREMEN eye drops;   Drug: Combigan®
Sponsor:   EMS
Not yet recruiting

Conditioned Pharmacotherapeutic Effects in Hypertension

Condition:   Hypertension
Intervention:   Drug: carvedilol
Sponsor:   University of Rochester
Completed

A Phase 3 Long-term Study of TAK-536 in Pediatric Patients 6 to Less Than 16 Years With Hypertension

Condition:   Pediatric Hypertension
Interventions:   Drug: TAK-536 2.5 mg;   Drug: TAK-536 5 mg
Sponsor:   Takeda
Completed

Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension

Conditions:   Hypotension, Orthostatic;   Hypertension;   Autonomic Nervous System Diseases
Interventions:   Drug: Yohimbine;   Drug: Melatonin
Sponsor:   Lawson Health Research Institute
Terminated

Quantitative Dual Energy Computed Tomography in Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Other: dual energy CT scans
Sponsor:   University Hospital, Bordeaux
Not yet recruiting

Hydroxyurea in Pulmonary Arterial Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Drug: Hydroxyurea
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   The Cleveland Clinic
Withdrawn

Efficacy and Tolerability of Subcutaneously Administered Treprostinil Sodium in Patients With Severe (Non-operable) Chronic Thromboembolic Pulmonary Hypertension (CTREPH)

Condition:   Non-operable Chronic Thromboembolic Pulmonary Hypertension
Intervention:   Drug: Treprostinil sodium
Sponsor:   SciPharm SàRL
Active, not recruiting

mDASHNa-CC APP to Support a Healthy Diet and Hypertension Control for Chinese Canadian Seniors

Conditions:   Hypertension;   Diet, Healthy
Intervention:   Device: mDASHNa App
Sponsor:   University of Toronto
Not yet recruiting

ORal IrON Supplementation With Ferric Maltol in Patients With Pulmonary Hypertension (ORION-PH-1)

Conditions:   Hypertension, Pulmonary;   Anemia, Iron Deficiency
Intervention:   Drug: Ferric maltol 30 mg (Feraccru®)
Sponsors:   Hannover Medical School;   Shields, Shields and Associates
Recruiting

A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (PAH)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Placebo;   Drug: Sotatercept
Sponsor:   Acceleron Pharma, Inc.
Recruiting

Spironolactone for Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   National Institutes of Health Clinical Center (CC);   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   University of Pennsylvania;   University of Maryland;   Washington Hospital Center;   New England Medical Center, Tufts University School of Medicine
Recruiting

A Study to Find Out if Selexipag is Effective and Safe in Patients With Chronic Thromboembolic Pulmonary Hypertension When the Disease is Inoperable or Persistent/Recurrent After Surgery

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Interventions:   Drug: Selexipag;   Drug: Placebo
Sponsor:   Actelion
Recruiting

Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)

Condition:   Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Interventions:   Drug: FDC macitentan/tadalafil;   Drug: Macitentan 10 mg;   Drug: Tadalafil 40 mg;   Drug: Placebo FDC;   Drug: Placebo macitentan;   Drug: Placebo tadalafil
Sponsors:   Actelion;   Covance;   Almac Clinical Technologies;   WorldCare Clinical;   Frontier Science Foundation
Not yet recruiting

A Study to Evaluate ALN-AGT01 in Patients With Hypertension

Condition:   Hypertension
Interventions:   Drug: ALN-AGT01;   Drug: ALN-AGT01-Matching Placebo;   Drug: Irbesartan;   Drug: Irbesartan-Matching Placebo
Sponsor:   Alnylam Pharmaceuticals
Recruiting

Furosemide for Accelerated Recovery of Blood Pressure Postpartum

Condition:   Hypertension, Pregnancy-Induced
Interventions:   Drug: Oral furosemide;   Drug: Placebo Oral Tablet
Sponsor:   University of Pennsylvania
Recruiting

BR1010 in Patients With Essential Hypertension Patients Who do Not Adequately Respond to Fimasartan/Amlodipine Combination

Condition:   Essential Hypertension
Intervention:   Drug: Fimasartan/Amlodipine
Sponsor:   Boryung Pharmaceutical Co., Ltd
Not yet recruiting

Combination of Fimasartan/Amlodipine/Rosuvastatin in Patients With Essential Hypertension and Dyslipidemia

Conditions:   Essential Hypertension;   Dyslipidemia
Interventions:   Drug: Fimasartan/Amlodipine, Rosuvastatin;   Drug: Fimasartan/Amlodipine;   Drug: Fimasartan, Rosuvastatin
Sponsor:   Boryung Pharmaceutical Co., Ltd
Completed

Endothelial Cell Dysfunction in Pulmonary Hypertension

Condition:   Secondary Pulmonary Arterial Hypertension
Interventions:   Procedure: Heart Catheterization;   Drug: Nitric Oxide;   Drug: Nitric Oxide/INO Pulse Delivery;   Drug: Sodium Nitrite
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed

DASH Diet Intervention at Senior Centers

Condition:   Hypertension
Interventions:   Behavioral: Revision of congregate meal menus and recipes to align with parameters of DASH eating plan;   Behavioral: On-site blood pressure monitoring;   Behavioral: Home self blood pressure monitoring;   Behavioral: Medical adherence education;   Behavioral: Nutrition Education
Sponsors:   Rockefeller University;   Carter Burden Network;   Clinical Directors Network
Not yet recruiting

Natural History Study of Biomarkers in Pulmonary Arterial Hypertension

Conditions:   Pulmonary Disease;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Institutes of Health Clinical Center (CC)
Recruiting

Fetal Endotracheal Occlusion (FETO) in the Resolution of Pulmonary Hypertension in Fetuses With Severe CDH

Condition:   Congenital Diaphragmatic Hernia
Intervention:   Device: Goldbal Detachable Balloon and delivery microcatheter
Sponsors:   Michael Belfort;   Baylor College of Medicine;   Texas Children's Hospital
Not yet recruiting

Repurposing a Histamine Antagonist to Benefit Patients With Pulmonary Hypertension

Conditions:   Pulmonary Arterial Hypertension;   Right Heart Failure
Interventions:   Drug: Famotidine 20 MG;   Other: Placebo
Sponsors:   University of Washington;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Optimizing Gestational Weight Gain, Birth Weight and Other Perinatal Outcomes Among Pregnant Women at Risk of Hypertension in Pregnancy

Conditions:   Hypertension, Pregnancy-Induced;   Hypertension, Essential Hypertension;   Hypertension; Pre-Eclampsia;   Hypertension in Pregnancy
Intervention:   Device: Self monitoring of blood pressure using Health Gauge Device and monthly monitoring of weight gain
Sponsors:   International Centre for Diarrhoeal Disease Research, Bangladesh;   Bill and Melinda Gates Foundation;   Salu Design Group
Recruiting

A Dose-escalation Study in Subjects With Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: GSK2586881
Sponsor:   GlaxoSmithKline
Completed

EXPERT, EXPosurE Registry RiociguaT in Patients With Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsor:   Bayer
Completed

A Pharmacist Intervention for Monitoring and Treating Hypertension Using Bidirectional Texting

Condition:   Hypertension
Interventions:   Other: Experimental: Pharmacist-Bidirectional Texting Group;   Other: Active Comparator: Control Group
Sponsors:   Linnea Polgreen;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

Vascular Responses to Sympathetic Activation and Altered Shear Rate: The Impact of Hypertension and Sodium Intake

Condition:   Hypertension
Interventions:   Dietary Supplement: Salt Pills;   Dietary Supplement: Placebo Pills
Sponsor:   Virginia Commonwealth University
Recruiting

Evaluation of Splenic Metabolic Activity With 18FDG-PET in Hypertension

Condition:   Hypertension
Intervention:   Other: PET/CT scan
Sponsor:   Neuromed IRCCS
Recruiting

A Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension

Conditions:   Glaucoma;   Open-Angle Ocular Hypertension
Interventions:   Drug: Bimatoprost SR;   Drug: Sham Bimatoprost SR;   Procedure: Selective Laser Trabeculoplasty;   Procedure: Sham Selective Laser Trabeculoplasty
Sponsor:   Allergan
Recruiting

A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Macitentan;   Other: Standard-of-care
Sponsor:   Actelion
Recruiting

Pulmonary Hypertension in Patients With Sickle Cell Disease in Nigeria

Conditions:   Secondary Pulmonary Arterial Hypertension;   Sickle Cell Disease;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

IV Iron Replacement for Iron Deficiency in Idiopathic Pulmonary Arterial Hypertension (IPAH) Patients

Conditions:   Pulmonary Arterial Hypertension;   Iron Deficiency
Interventions:   Drug: Saline;   Drug: Ferinject or CosmoFer
Sponsors:   Imperial College London;   Fu Wai Hospital, Beijing, China
Completed

Extension Study for Participants in LIQ861 Trials to Evaluate the Long-term Safety of Dry Powder Inhalation of Treprostinil

Condition:   Primary Pulmonary Hypertension
Intervention:   Drug: LIQ861 Inhaled Treprostinil
Sponsors:   Liquidia Technologies, Inc.;   Nuventra, Inc.
Not yet recruiting

Primary Aldosteronism and Surgically Curable Forms in Hypertension Patients Using 11C-Metomidate

Conditions:   Primary Aldosteronism;   Primary Aldosteronism Due to Aldosterone Producing Adenoma
Intervention:   Combination Product: 11C-Metomidate PET/CT Scan
Sponsors:   Changi General Hospital;   National University Health System, Singapore;   Clinical Imaging Research Centre;   Singapore General Hospital;   Tan Tock Seng Hospital;   Khoo Teck Puat Hospital;   Ng Teng Fong General Hospital
Recruiting

Adrenal Suppression and Absorption Study of Halobetasol Propionate Foam in Subjects 12-17 With Plaque Psoriasis

Condition:   Plaque Psoriasis
Intervention:   Drug: Halobetasol Topical Foam
Sponsor:   Mayne Pharma International Pty Ltd
Recruiting

To Achieve Blood Pressure Control With Retained Quality of Life

Conditions:   Hypertension;   Patient Compliance
Intervention:  
Sponsor:   Eva Drevenhorn
Recruiting

Long-term Ambrisentan Extension Study for Pediatric Patients Who Participated in AMB112529

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Ambrisentan
Sponsor:   GlaxoSmithKline
Recruiting

A Study of Oral Nitrate in Adults With Pulmonary Hypertension With Heart Failure and Preserved Ejection Fraction

Conditions:   Pulmonary; Hypertension;   Heart Failure;   Preserved Ejection Fraction
Interventions:   Drug: 15N Nitrate;   Drug: 14N Nitrate
Sponsors:   Gladwin, Mark, MD;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Efficacy of Palatinose™ Versus Sucrose on Flow Mediated Dilation in Healthy Subjects With Mild Hypertension

Condition:   Overweight and Obesity
Interventions:   Dietary Supplement: isomaltulose;   Dietary Supplement: sucrose
Sponsor:   Beneo-Institute
Completed

Cerebral Autoregulation in Patients With Aneurysmal SubArachnoid Haemorrhage

Condition:   Subarachnoid Hemorrhage, Aneurysmal
Interventions:   Other: Hypertension;   Other: Hyper- and hypoxia;   Other: Hyper- and hypocapnia
Sponsor:   Rigshospitalet, Denmark
Recruiting

Cardiopulmonary Toxicity of Thoracic Radiotherapy

Conditions:   Oesophageal Cancer;   Non Small Cell Lung Cancer
Intervention:  
Sponsor:   University Medical Center Groningen
Recruiting

Chlorhexidine Mouthwash and Oral Nitrate in Adults With Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Heart Failure With Normal Ejection Fraction;   Pulmonary Heart Disease and Diseases of Pulmonary Circulation
Interventions:   Drug: Nitrates;   Drug: Chlorhexidine Gluconate Mouthwash;   Drug: Placebo Mouthwash
Sponsors:   Gladwin, Mark, MD;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI);   University of Pittsburgh
Not yet recruiting

Project IMPACT: CHW Intervention

Condition:   Hypertension
Interventions:   Behavioral: CHW Intervention;   Behavioral: Wait List Control Group
Sponsor:   NYU Langone Health
Active, not recruiting

Impact of Providing Medical Records in a Patient-Centered, Community Pharmacy Based, HIV Care Model (HIV-MOI)

Conditions:   HIV/AIDS;   Diabetes Mellitus, Type 2;   Hypertension
Intervention:   Other: Medication optimization intervention
Sponsors:   University of North Texas Health Science Center;   University of California, San Francisco;   University of Minnesota - Clinical and Translational Science Institute
Recruiting

PRIMEx - A Study of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH)

Condition:   PAH
Interventions:   Drug: 75mg CXA-10;   Drug: 150mg CXA-10;   Other: Placebo
Sponsors:   Complexa, Inc.;   Medpace, Inc.;   Philips Healthcare;   Cardiovascular Clinical Science Foundation;   MicroConstants
Recruiting

Open-label, Multi-center Protocol to Provide QTI571 to PAH Patients Who Participated in the Extension Study (A2301E1) in Japan

Condition:   Severe Pulmonary Arterial Hypertension
Intervention:   Drug: QTI571
Sponsor:   Novartis Pharmaceuticals
Completed

Effects of Oral Sildenafil on Mortality in Adults With PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: sildenafil citrate
Sponsor:   Pfizer
Recruiting

Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH

Condition:   Pulmonary Artery Hypertension
Intervention:  
Sponsor:   Laval University
Not yet recruiting

A Phase III Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution Compared With Latanoprost Ophthalmic Solution in Subjects With OAG or OHT

Condition:   Open Angle Glaucoma or Ocular Hypertension
Interventions:   Drug: DE-117;   Drug: Latanoprost ophthalmic solution
Sponsor:   Santen Pharmaceutical Co., Ltd.
Completed

Hypertension Management in Cancer Patients

Conditions:   Blood Pressure;   Hypertension;   Cancer;   Cancer, Breast;   Cancer of Prostate;   CLL;   Hematopoietic Malignancy
Intervention:   Other: Automated Messaging
Sponsors:   Duke University;   Duke Institute for Health Innovation
Not yet recruiting

Long-term Safety and Efficacy Extension Trial of Bimatoprost SR

Conditions:   Open-Angle Glaucoma;   Ocular Hypertension
Intervention:   Drug: Bimatoprost SR
Sponsor:   Allergan
Recruiting

The TARGET BP OFF-MED Trial

Conditions:   Hypertension;   Hypertension,Essential
Interventions:   Drug: Alcohol;   Other: Sham control
Sponsor:   Ablative Solutions, Inc.
Recruiting

Role of Nitric Oxide in Malaria

Conditions:   Malaria;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

TARGET BP I Clinical Trial

Condition:   Hypertension
Interventions:   Drug: Dehydrated alcohol;   Device: Peregrine System Kit (Sham Procedure)
Sponsor:   Ablative Solutions, Inc.
Not yet recruiting

Acute Effect of Isometric Exercise on Blood Pressure in Hypertensive Patients

Condition:   Arterial Hypertension
Interventions:   Other: isometric handgrip exercise;   Other: isometric of the lower limbs
Sponsor:   Instituto de Cardiologia do Rio Grande do Sul
Not yet recruiting

Training in the 21st Century: Using Virtual Role-Plays to Improve Nurse Communication for Medication Adherence

Conditions:   High Blood Pressure;   Hypertension
Intervention:   Behavioral: Audiotaped Counseling Session
Sponsor:   NYU Langone Health
Not yet recruiting

Validation of New Tools for the Assessment of Cognitive Functions and Connectivity Network in Hypertensive Patients

Conditions:   Hypertension;   Cognitive Impairment
Intervention:  
Sponsor:   Neuromed IRCCS
Recruiting

Study 3: Minocycline Decreases Microglia Activation

Condition:   Hypertension
Intervention:   Drug: Minocycline
Sponsors:   University of Florida;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Kidney Check: Diabetes, Blood Pressure & Kidney Health Checks & Care in Indigenous Communities.

Conditions:   Chronic Kidney Disease;   Diabetes;   Hypertension
Intervention:   Other: Point-of-care screening
Sponsors:   University of Manitoba;   Canadians Seeking Solutions and Innovations to Overcome Chronic Kidney Disease;   Alberta Health Services;   First Nations Health Authority;   First Nations Health and Social Secretariat of Manitoba;   Manitoba Renal Program
Not yet recruiting

Hypoxia and Inflammatory Injury in Human Renovascular Hypertension

Conditions:   Renal Artery Stenosis;   Ischemic Nephropathy;   Renovascular Disease;   Chronic Kidney Disease
Interventions:   Drug: Mesenchymal stem cell;   Procedure: Mesenchymal stem cell delivery with stent placement
Sponsors:   Mayo Clinic;   University of Mississippi Medical Center;   University of Alabama at Birmingham
Active, not recruiting

Study of Netarsudil Ophthalmic Solution in Subjects With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT)

Condition:   Primary Open Angle Glaucoma or Ocular Hypertension
Interventions:   Drug: Netarsudil Ophthalmic Solution 0.02%;   Other: Placebo Comparator
Sponsor:   Aerie Pharmaceuticals
Completed

An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease;   Combined Pulmonary Fibrosis and Emphysema
Intervention:   Drug: Inhaled Treprostinil
Sponsor:   United Therapeutics
Enrolling by invitation

A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Patients With PH Due to COPD

Conditions:   Pulmonary Hypertension;   Chronic Obstructive Pulmonary Disease
Interventions:   Drug: Inhaled treprostinil solution;   Drug: Placebo solution
Sponsor:   United Therapeutics
Recruiting

Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease;   Combined Pulmonary Fibrosis and Emphysema
Interventions:   Drug: Inhaled Treprostinil;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting

Immunological Profile in Relation to Cardiac Geometry in Hypertension

Condition:   Immune System Profile During Hypertensive Cardiac Remodeling
Intervention:  
Sponsor:   Neuromed IRCCS
Recruiting

Heart Inflammation and Mental Stress Study

Condition:   Hypertension
Interventions:   Behavioral: Paced breathing;   Behavioral: Music relaxation
Sponsors:   University of Miami;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

Conditions:   Obstructive Sleep Apnea of Adult;   Preeclampsia;   Obstetrical Complications
Interventions:   Device: Continuous Positive Airway Pressure;   Other: Sleep Hygiene Control
Sponsors:   The George Washington University Biostatistics Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

The Effects of Hot Yoga on Vascular Function

Conditions:   Hypertension;   Elevated Blood Pressure
Intervention:   Behavioral: Hot Yoga
Sponsor:   Texas State University
Recruiting

Effect of Occupational Therapy in Promoting Medication Adherence

Conditions:   Hypertension;   Diabete Type 2
Interventions:   Behavioral: Treatment as Usual Plus Occupational Therapy;   Behavioral: Treatment as Usual
Sponsors:   University of Indianapolis;   University of Missouri, Kansas City;   Missouri State University
Completed

A Feasibility Study to Evaluate the Effect of Concomitant Renal Denervation and Cardiac Ablation on AF Recurrence

Conditions:   Persistent Atrial Fibrillation;   Paroxysmal Atrial Fibrillation;   Hypertension
Interventions:   Device: Renal Artery Ablation;   Device: Cardiac Ablation
Sponsor:   Abbott Medical Devices
Completed

Evaluation of Safety and Efficacy of Brimonidine Tartrate Ophthalmic Suspension

Conditions:   Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Brimonidine Tartrate Ophthalmic Suspension;   Drug: Brimonidine Tartrate Ophthalmic Solution
Sponsor:   Sun Pharma Advanced Research Company Limited
Recruiting

24-Hour Ambulatory Blood Pressure Monitoring in Community Pharmacies

Condition:   Hypertension
Intervention:   Other: ABPM service by Pharmacists
Sponsor:   Virginia Commonwealth University
Recruiting

Hemodynamic Evaluation of Levosimendan in Patients With PH-HFpEF

Conditions:   Hypertension Pulmonary Secondary;   Heart Failure, Right Sided;   Heart Failure With Normal Ejection Fraction
Interventions:   Drug: Levosimendan;   Drug: Matching Placebo
Sponsor:   Tenax Therapeutics, Inc.
Recruiting

HR Versus RFA for HCC in Patients With PHT

Conditions:   Carcinoma, Hepatocellular;   Liver Neoplasms;   Neoplasms, Glandular and Epithelial
Interventions:   Procedure: Hepatic Resection;   Procedure: Radiofrequency Ablation
Sponsor:   Guangxi Medical University
Recruiting

Novel Approaches of Advanced Neuroimaging Based on MRI Fiber Tracking to Detect Early Signs of Vascular Cognitive Impairment in Hypertensive Patients

Condition:   Hypertension
Intervention:   Other: No interventions
Sponsors:   Neuromed IRCCS;   IRCCS Multimedica
Not yet recruiting

Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients

Conditions:   Hypertension Pulmonary Secondary Heart Failure;   Right Sided Heart Failure With Normal Ejection Fraction;   Heart Failure With Normal Ejection Fraction
Intervention:   Drug: Levosimendan 2.5 mg/ml Injectable Solution
Sponsor:   Tenax Therapeutics, Inc.
Recruiting

Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia

Conditions:   Sickle Cell Disease;   Chronic Kidney Disease;   Pulmonary Hypertension
Intervention:   Drug: Erythropoietin and Hydroxyurea
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome

Condition:   Cushing Syndrome
Interventions:   Drug: Relacorilant;   Other: Placebo
Sponsor:   Corcept Therapeutics
Recruiting

Effectiveness of Prazosin on the Urinary Sodium Excretion Response to Mental Stress

Conditions:   Hypertension;   Stress, Psychological;   Blood Pressure
Interventions:   Drug: Prazosin;   Drug: Placebo
Sponsors:   Augusta University;   The University of Texas at Arlington
Completed

nuMoM2b Heart Health Study

Conditions:   Pregnancy Complicated by Cardiovascular Disorders as Postpartum Condition, Delivered During Previous Episode;   Breathing-Related Sleep Disorder
Intervention:  
Sponsors:   RTI International;   National Heart, Lung, and Blood Institute (NHLBI);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting

Study Title: Food Rx

Conditions:   Diabetes;   High Blood Pressure;   Obesity;   Hypertension;   Heart Diseases;   Stroke;   TIA;   Osteoarthritis;   Cancer
Intervention:   Behavioral: Nutrition Education
Sponsor:   Mayo Clinic
Recruiting

Motivational Interviewing (MI) Intervention to Improve Adherence

Conditions:   Diabetes Mellitus, Type 2;   Hypertension
Intervention:   Behavioral: Motivational interviewing intervention arm
Sponsors:   University of Houston;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Renal Artery Denervation In Addition to Catheter Ablation To Eliminate Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Hypertension
Interventions:   Procedure: catheter ablation;   Procedure: renal sympathetic denervation
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Completed

A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

Conditions:   PAH;   Pulmonary Hypertension;   Pulmonary Arterial Hypertension;   Hypertension;   Connective Tissue Diseases;   Familial Primary Pulmonary Hypertension;   Vascular Diseases;   Cardiovascular Diseases;   Hypertension, Pulmonary;   Lung Diseases;   Respiratory Tract Disease
Intervention:   Drug: Ralinepag
Sponsor:   United Therapeutics
Enrolling by invitation

Assessing Response to Inhaled Prostacyclin With Hyperpolarized Xe MRI

Condition:   Pulmonary Vascular Disease
Intervention:   Drug: Hyperpolarized 129Xenon gas
Sponsors:   Bastiaan Driehuys;   United Therapeutics
Recruiting

Dietary Prevention of Heart Failure in Hypertensive Metabolic Syndrome

Condition:   Heart Failure
Interventions:   Behavioral: Performance of WHEELS-I in promoting DASH/SRD adoption;   Behavioral: Effects of a 2-week DASH/SRD intervention vs. control diet on HFpEF functional cardiovascular risk factors
Sponsor:   VA Office of Research and Development
Recruiting

Marinobufagenin as a Target for DIGIBIND in Preeclampsia

Condition:   Preeclampsia
Intervention:  
Sponsor:   National Institute on Aging (NIA)
Completed

Effects of an Immunosuppressant Mycophenolate Mofetil or MMF on the Urinary Sodium Excretion Response to Mental Stress

Conditions:   Psychological Stress;   Hypertension, Renal
Interventions:   Drug: mycophenolate mofetil (MMF);   Drug: Placebo
Sponsor:   Augusta University
Recruiting

Valsartan Versus Amlodipine Effect on Left Ventricular Multidirectional Deformation and Adipocytokines Level

Condition:   Hypertension
Interventions:   Drug: valsartan (160 mg/d);   Drug: amlodipine (10 mg/d).
Sponsors:   Damanhour University;   Tanta University
Completed

Comparison of the Medication Adherence of Patients Treated With Telmisartan/Hydrochlorothiazide or Telmisartan/Amlodipine Fixed Dose Combination (FDC) Versus Double-pill Combination Therapy in Real-world Japanese Therapeutic Practice

Condition:   Hypertension
Interventions:   Drug: subjects treated with telmisartan/hydrochlorothiazide;   Drug: Subjects treated with Telmisartan and amlodipine;   Drug: subjects treated with Telmisartan+hydrochlorothiazide double-pill combination group;   Drug: subjects treated with telmisartan+amlodipine double pill
Sponsor:   Boehringer Ingelheim
Not yet recruiting

Indian Ragas on Health - a Electrophysiological Study (RAGA-1)

Condition:   Hypertension
Intervention:   Other: Music Intervention
Sponsors:   MS Ramaiah Medical College & Hospitals;   Rajiv Gandhi University of Health Sciences
Active, not recruiting

A Pilot Study to Assess the Accuracy of Blood Pressure Assessment by the Omron HeartGuide Smartwatch

Conditions:   Hypertension;   Cardiac Disease;   Surgery
Interventions:   Other: Omron Wearable Device;   Other: Standard Arterial Line
Sponsor:   The Cleveland Clinic
Recruiting

Comparing Refractive and Visual Outcomes of MIGS and Traditional Surgeries

Conditions:   Glaucoma;   Ocular Hypertension
Intervention:  
Sponsors:   Wills Eye;   Allergan;   The American Society of Cataract and Refractive Surgery Foundation
Enrolling by invitation

Outcomes of Laparoscopic Sleeve Gastrectomy

Conditions:   Bariatric Surgery Candidate;   Laparoscopic Sleeve Gastrectomy;   Obesity, Morbid
Intervention:   Procedure: Laparoscopic sleeve gastrectomy
Sponsor:   Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Completed

LCZ696 in Advanced LV Hypertrophy and HFpEF

Conditions:   Heart Failure;   Essential Hypertension
Interventions:   Drug: LCZ 696;   Drug: Enalapril
Sponsors:   National Medical Research Center for Cardiology, Ministry of Health of Russian Federation;   Ministry of Health of Russian Federation
Recruiting

Effectiveness of Avapro in Obese Normotensive/Hypertensive African Americans

Conditions:   Hypertension;   Obesity;   Stress, Psychological;   Blood Pressure
Interventions:   Drug: Irbesartan;   Other: Placebo
Sponsor:   Augusta University
Recruiting

Radiomics-based Surrogate of Endoscopy (rEndosc) (CHESS1703)

Condition:   Esophageal Varices in Cirrhosis of the Liver
Interventions:   Procedure: Endoscopy;   Procedure: CTA
Sponsors:   Nanfang Hospital of Southern Medical University;   Beijing YouAn Hospital;   Beijing 302 Hospital;   Shandong Provincial Hospital;   Beijing Friendship Hospital;   The Second Affiliated Hospital of Chongqing Medical University;   Chinese PLA General Hospital;   Peking University People's Hospital;   Xingtai People's Hospital
Withdrawn

A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Conditions:   PAH;   Pulmonary Hypertension;   Pulmonary Arterial Hypertension;   Hypertension;   Connective Tissue Diseases;   Familial Primary Pulmonary Hypertension;   Vascular Diseases;   Cardiovascular Diseases;   Hypertension, Pulmonary;   Lung Diseases;   Respiratory Tract Disease
Interventions:   Drug: Ralinepag;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

Conditions:   Adrenal Gland Neoplasm;   Hypertension;   Bone Diseases, Metabolic;   Cardiovascular Disease;   Hyperinsulinemia
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

The Effect of Early Screening and Intervention for Gestational Diabetes Mellitus on Pregnancy Outcomes

Conditions:   Pregnancy Complications;   Gestational Diabetes Mellitus in Pregnancy
Interventions:   Other: early screening and intervention;   Other: standard screening and intervention
Sponsor:   National Taiwan University Hospital
Recruiting

Fixed Combination for Lipid and Blood Pressure Control

Conditions:   Arterial Hypertension;   Dyslipidemias;   Blood Pressure;   Lipid Metabolism Disorders
Intervention:   Drug: Atorvastatin, Amlodipine, Perindopril
Sponsors:   Charles University, Czech Republic;   University Hospital Olomouc;   University Hospital Pilsen;   General Teaching Hospital, Prague;   St. Anne;   Brno University Hospital;   Na Homolce Hospital
Withdrawn

Evaluation of an Electronic CKD Clinical Decision Support System (CDSS) in Clinical Care

Conditions:   Hypertension;   Renal Insufficiency, Chronic
Interventions:   Other: Clinical Decision Support System (CDSS);   Other: Clinic Decision Sup System + Pharmacist
Sponsor:   University of California, San Francisco
Active, not recruiting

Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial

Conditions:   Preeclampsia Severe;   Preeclampsia Postpartum
Interventions:   Drug: Ibuprofen 600 mg;   Drug: Ketorolac;   Drug: Acetaminophen;   Drug: Oxycodone
Sponsor:   Washington University School of Medicine
Recruiting

Effect of Two Exercise Programs on Obese Patients

Conditions:   Obesity;   Hypertension
Intervention:   Other: Exercise Type
Sponsor:   Rowan University
Recruiting

RNA Sequencing in the Framingham Heart Study Third Generation Cohort Exam 2

Conditions:   Cardiovascular Disease;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Practice-Based Trial of Home BP Telemonitoring Among Minority Stroke Survivors

Conditions:   Stroke;   Hypertension
Interventions:   Behavioral: Home BP Telemonitoring (HBPTM);   Behavioral: Nurse Case Management (NCM)
Sponsors:   NYU Langone Health;   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting

Ability of Carotid Sonography and Inferior Vena Cava Sonography for the Prediction of Post-induction Hypotension in Hypertensive Patients

Condition:   General Anesthesia
Intervention:   Biological: carotid sonography and inferior vena cava sonography
Sponsor:   Yonsei University
Not yet recruiting

Prepared Meals to Prime and Perpetuate Reduced Dietary Sodium Intake in Hemodialysis

Conditions:   Hypertension in Dialysis Patients;   Fluid Overload in Dialysis Patients
Interventions:   Other: Sodium Restricted Meals;   Other: Control
Sponsor:   Tufts Medical Center
Not yet recruiting

Sildenafil for the Prevention of Right Heart Failure Following LVAD Implantation

Condition:   End Stage Heart Failure
Intervention:   Drug: Sildenafil Citrate
Sponsors:   University of Calgary;   Pfizer
Recruiting

Relationship of the Physical Activity Practice and Its Different Domains With Cardiac Autonomic Modulation

Condition:   Adult Disease
Intervention:  
Sponsors:   Bruna Thamyres Ciccotti Saraiva;   Fundação de Amparo à Pesquisa do Estado de São Paulo
Recruiting

A Randomised Controlled Trial of Coenzyme Q10 in Patients With Schizophrenia and Schizoaffective Disorder

Conditions:   Schizophrenia;   Schizoaffective Disorder
Interventions:   Dietary Supplement: Coenzyme Q10;   Other: Placebo
Sponsors:   University of Dublin, Trinity College;   Liverpool John Moores University;   Royal Liverpool University Hospital
Active, not recruiting

Laparoscopic Versus Open Distal Pancreatectomy for Pancreatic Cancer: a Multicenter Randomized Controlled Trial

Condition:   Pancreas Neoplasm Malignant Resectable
Interventions:   Procedure: Laparoscopic distal pancreatectomy;   Procedure: open distal pancreatectomy
Sponsors:   Seoul National University Hospital;   Seoul National University Bundang Hospital;   Severance Hospital;   Asan Medical Center;   Seoul St. Mary's Hospital
Recruiting

Evaluation of Sickle Cell Liver Disease

Condition:   Sickle Cell Disease
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Thymoglobulin Induction Therapy With Minimal Immunosuppression and Evaluation of Allograft Status

Condition:   Immunosuppression
Intervention:   Drug: Tacrolimus
Sponsor:   Weill Medical College of Cornell University
Terminated

Treatment for Non-Alcoholic Fatty Liver With Different Doses of Vitamin E

Condition:   Fatty Liver
Interventions:   Drug: Vitamin E 200 IU/d;   Drug: Vitamin E 400 IU/d;   Drug: Vitamin E 800 IU/d;   Behavioral: Diet and Exercise
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting

Effects of Propranolol on Responses to Drug-Related Imagery Scripts

Condition:   Cocaine Dependence
Interventions:   Drug: Propranolol;   Drug: Placebo
Sponsor:   National Institute on Drug Abuse (NIDA)
Terminated

The VA Diabetes Trial Follow-up Study (VADT-FS)

Conditions:   Diabetes;   Glycemic Control
Intervention:  
Sponsor:   VA Office of Research and Development
Completed

Diagnosis of Pheochromocytoma

Conditions:   Pheochromocytoma;   Endocrine Disease;   Endocrine Diseases
Interventions:   Drug: Fluorodopamine;   Drug: F-18 Fluorodopa
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Clonidine for Relapse Prevention in Buprenorphine-Maintenance Patients

Condition:   Opioid-Related Disorders
Interventions:   Drug: Clonidine;   Drug: Placebo
Sponsor:   National Institute on Drug Abuse (NIDA)
Completed

Economic Crisis and Adherence to the Mediterranean Diet (CASSIOPEA)

Conditions:   Dietary Habits;   Inflammation;   Economic Problems;   Obesity;   Diabetes;   Hypertension
Intervention:  
Sponsor:   Neuromed IRCCS
Recruiting

Role of Wrist Based Blood Pressure Monitoring in Clinical Practice

Conditions:   Blood Pressure;   Transitions of Care
Intervention:  
Sponsor:   Scripps Translational Science Institute
Enrolling by invitation

Improving Mental Health Through Integration With Primary Care in Rural Karnataka

Conditions:   Chronic Disease;   Depression;   Anxiety
Intervention:   Behavioral: Healthy Living Intervention
Sponsors:   University of California, San Francisco;   National Institute of Mental Health (NIMH)
Active, not recruiting

Microbiome/Peptidome-based Model for Non-invasive Detection of High-risk Gastroesophageal Varices in Compensated Cirrhosis (CHESS1901/APPHA1901)

Condition:   Compensated Cirrhosis
Intervention:   Diagnostic Test: esophagogastroduodenoscopy
Sponsors:   Nanfang Hospital of Southern Medical University;   Southern Medical University, China;   LanZhou University;   Zhongda Hospital, Medical School, Southeast University;   Guangdong Second Provincial General Hospital;   Xingtai People's Hospital;   The Third Hospital of Zhenjiang Affiliated Jiangsu University;   Tianjin Second People's Hospital;   Zhejiang University Lishui Hospital;   the Second Affiliated Hospital of Anhui Medical University;   The sixth people's hospital of Shenyang;   Xi’an Gaoxin Hospital;   King Chulalongkorn Memorial Hospital affiliated to Chulalongkorn University;   Ankara University
Recruiting

Effect of Gymnema Sylvestre on Metabolic Syndrome and Insulin

Condition:   Metabolic Syndrome
Interventions:   Drug: Placebo;   Drug: Gymnema Sylvestre
Sponsor:   University of Guadalajara
Completed

Magnetically Controlled Capsule Endoscopy for Assessing Risk of Gastroesophageal Varices Bleeding in Compensated Cirrhosis (CHESS1801)

Conditions:   Compensated Cirrhosis;   Gastroesophageal Varices Bleeding
Intervention:   Diagnostic Test: Magnetically controlled capsule endoscopy
Sponsors:   Nanfang Hospital of Southern Medical University;   PLA Army General Hospital;   Sir Run Run Shaw Hospital, Medical College, Zhejiang University;   Zhujiang Hospital;   Shandong Provincial Hospital;   Shanghai Tongji Hospital, Tongji University School of Medicine;   The First Affiliated Hospital of Nanchang University;   Zhongda Hospital, Medical School, Southeast University;   Guangdong Second Provincial General Hospital;   the Fifth Affiliated Hospital of Zunyi Medical University;   LanZhou University;   Xingtai People's Hospital
Recruiting

Prediction and Prevention of Asymptomatic Cardiovascular Insult in Type 1 Diabetic Children: Comparative Effectiveness of Cardioprotective Drugs

Condition:   Diabetes Mellitus, Type 1
Interventions:   Drug: Atorvastatin;   Drug: Captopril;   Drug: L-carnitine
Sponsor:   Tanta University
Completed

Abiraterone With Different Steroid Regimens for Side Effect Related to Mineralcorticoid Excess Prevention in Prostate Cancer Prior to Chemotherapy

Condition:   Prostate Cancer
Interventions:   Drug: Abiraterone Acetate;   Drug: Prednisone 5 mg twice daily;   Drug: Prednisone 5 mg once daily;   Drug: Prednisone 2.5 mg twice daily;   Drug: Dexamethasone 0.5 mg once daily
Sponsor:   Janssen Pharmaceutica N.V., Belgium
Completed

Latinos Understanding the Need for Adherence in Diabetes

Conditions:   Type 2 Diabetes;   Glycemic Control;   Cardiovascular Risk Factors;   Psychological Distress
Intervention:   Behavioral: Special Intervention
Sponsor:   San Diego State University
Completed

Non-invasive Methods to Predict PHG in Cirrhosis

Condition:   Cirrhosis
Intervention:  
Sponsor:   Second Affiliated Hospital of Xi'an Jiaotong University
Completed

Modifying Diet to Improve Gut Microbiome

Condition:   Obesity
Interventions:   Behavioral: DASH diet;   Behavioral: standard American diet
Sponsor:   University of Alabama at Birmingham
Not yet recruiting

Care Coordination for Complex Cancer Survivors in an Integrated Safety Net System

Conditions:   Breast Cancer;   Colorectal Cancer
Intervention:   Other: Care Coordination Strategies
Sponsor:   University of Texas Southwestern Medical Center
Enrolling by invitation

Non-Invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129Xe Magnetic Resonance Imaging

Condition:   Pulmonary Vascular Disease
Interventions:   Drug: GE-141, Hyperpolarized 129Xenon gas;   Device: MRI
Sponsors:   Bastiaan Driehuys;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Study of Clonidine Efficacy for the Treatment of Impulse Control Disorders in Parkinson's Disease:

Conditions:   Parkinson's Disease;   Mpulse Control Disorders
Interventions:   Drug: placebo;   Drug: Clonidine
Sponsor:   Hospices Civils de Lyon
Recruiting

Preliminary Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low-weight Infants

Condition:   Patent Ductus Arteriosus
Interventions:   Device: Cather closure of patent ductus arteriosus (PDA);   Other: Conservative management of patent ductus arteriosus (PDA)
Sponsors:   Nationwide Children's Hospital;   University of Tennessee Health Science Center
Not yet recruiting

How Does Antiretroviral Therapy Affect Coronary Atherosclerosis: A Serial CT Study

Conditions:   Coronary Artery Disease;   Hiv
Intervention:   Drug: Biktarvy
Sponsor:   Professor Saye Khoo MD, FRCP
Not yet recruiting

The Safety, Tolerability and Efficacy of Dronabinol, for the Treatment of Nausea and Vomiting in Familial Dysautonomia

Conditions:   Nausea;   Vomiting;   Familial Dysautonomia
Interventions:   Drug: Dronabinol;   Other: Placebo
Sponsor:   NYU Langone Health
Withdrawn

PREMOD2 With Near Infrared Spectroscopy Sub-study

Conditions:   Hypoxia, Brain;   Premature Birth
Interventions:   Procedure: Umbilical cord milking;   Procedure: Delayed Cord Clamping
Sponsors:   Sharp HealthCare;   University of Ulm;   University College Cork;   University of Alberta;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting

Prevention of Critical Incidents Related to the Nursing With Patients in Intensive Care Units

Condition:   Acute Conditions in Intensive Care
Intervention:   Behavioral: Best practices
Sponsor:   Central Hospital, Nancy, France
Recruiting

Investigating Idiopathic Pulmonary Fibrosis in Greece (INDULGE IPF)

Condition:   Idiopathic Pulmonary Fibrosis
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Select Indian Ragas on Electrophysiological Parameters

Conditions:   Psychology, Social;   Stress;   Stress, Psychological
Intervention:   Other: Music intervention
Sponsors:   MS Ramaiah Medical College & Hospitals;   Indian Council of Medical Research
Recruiting

Evaluation of Toxicity From Stem Cell Transplant

Conditions:   Organ Dysfunction;   Hemolysis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

NIRS Directed Optimal Cerebral Perfusion Pressure in Septic Shock Patients: A Feasibility Study

Condition:   The Time Used for Determining Optimal CPP
Intervention:   Device: Continuous NIRS monitoring
Sponsor:   Xiangya Hospital of Central South University
Not yet recruiting

Clinical Laboratory Evaluation of Chronic Autonomic Failure

Conditions:   Parkinson's Disease;   Multiple System Atrophy;   Autonomic Failure
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Adrenergic Blockers for Cardiac Changes in Early Parkinson's Disease

Conditions:   REM Sleep Behavior Disorder;   Pre-motor Parkinson Disease;   Symptomatic Parkinson Disease
Intervention:   Drug: Carvedilol
Sponsor:   Michele Tagliati, MD
Recruiting

NIRS Directed Optimal Cerebral Perfusion Pressure in Aneurysmal Subarachnoid Hemorrhage Patients: A Feasibility Study

Condition:   The Time for Determine CPPopt
Intervention:   Device: NIRS monitoring
Sponsor:   Xiangya Hospital of Central South University
Not yet recruiting

Genetically Determined Response to Atenolol in Patients With Persistent Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Drug: Atenolol
Sponsor:   Vanderbilt University Medical Center
Completed

Understanding the Pathophysiology of Migraine Pain

Conditions:   Migraine Disorders;   Migraine, Classic;   Migraine Without Aura
Intervention:   Other: Nitroglycerin
Sponsor:   Montefiore Medical Center
Recruiting

Reference Values for Plasma Catechols

Conditions:   Healthy Volunteers;   Normal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

A Dose Finding Study To Evaluate Safety, Drug Interaction, Tumor Markers Of Axitinib In Combination With MK-3475 In Adult Patients With Previously Untreated Advanced Renal Cell Cancer

Condition:   Renal Cell Carcinoma
Interventions:   Drug: Axitinib;   Drug: MK-3475
Sponsors:   Pfizer;   Merck Sharp & Dohme Corp.
Active, not recruiting

Skin Sympathetic Nerve Activity and Cardiac Arrhythmias

Condition:   Sympathetic Nerve Activity
Intervention:   Other: Physiologic maneuvers
Sponsors:   Cedars-Sinai Medical Center;   National Institutes of Health (NIH)
Withdrawn

BAY 43-9006 (Sorafenib) and Bevacizumab (Avastin) To Treat Solid Tumors

Condition:   Neoplasms
Interventions:   Drug: Bevacizumab;   Drug: BAY 43-9006
Sponsor:   National Cancer Institute (NCI)
Completed

A Phase 1b Study Of Axitinib In Combination With Crizotinib In Patients With Advanced Solid Tumors

Condition:   Advanced Solid Tumors
Interventions:   Drug: axitinib;   Drug: crizotinib
Sponsor:   Pfizer
Active, not recruiting

Revisional Bariatric Surgery Experience

Conditions:   Bariatric Surgery;   Revisional Bariatric Surgery;   Obesity Associated Disorder
Interventions:   Other: Laparoscopic mini gastric by-pass;   Other: LaparoscopicRe-sleeve gastrectomy;   Other: Laparoscopic Roux-en-Ygastric bypass
Sponsor:   Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Completed

A Randomized Controlled Trial of Doxazosin for Nightmares, Sleep Disturbance, and Non-Nightmare Clinical Symptoms in PTSD

Condition:   Stress Disorders, Post-Traumatic
Interventions:   Drug: Doxazosin Mesylate, Extended Release;   Drug: Placebo
Sponsors:   San Francisco Veterans Affairs Medical Center;   United States Department of Defense;   Northern California Institute of Research and Education
Recruiting

Xarelto Versus no Treatment for the Prevention of Recurrent Thrombosis in Patients With Chronic Portal Vein Thrombosis.

Conditions:   Deep Vein Thrombosis;   Chronic Portal Vein Thrombosis
Intervention:   Drug: Xarelto
Sponsor:   Assistance Publique - Hôpitaux de Paris
Active, not recruiting

Examining Risk Factors for Atypical Antipsychotic Metabolic Side Effects

Condition:   Schizophrenia
Interventions:   Dietary Supplement: Folic Acid;   Other: Placebo
Sponsors:   University of Michigan;   National Institute of Mental Health (NIMH)
Completed

Effect of an Anti-inflammatory Diet on Patients With Cervical Cancer

Conditions:   Cervical Cancer;   Uterine Cervical Neoplasm;   Pelvic Inflammatory Disease;   Radiation Toxicity;   Diet Modification
Interventions:   Other: Omega-3 fatty acids;   Other: Antioxidants;   Other: Soluble fiber;   Other: Probiotics;   Other: Lactose restriction;   Other: Fiber restriction;   Other: Fat restriction
Sponsor:   National Institute of Cancerología
Recruiting

Exertional Exhaustion in Chronic Fatigue Syndrome

Condition:   Chronic Fatigue Syndrome
Intervention:   Procedure: Submaximal bicycle exercise stress test on Days 1 and 2
Sponsor:   Georgetown University
Completed

Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IV Head and Neck Cancer

Conditions:   Head and Neck Squamous Cell Carcinoma;   Stage IVA Oropharyngeal Carcinoma AJCC v7;   Stage IVB Oropharyngeal Carcinoma AJCC v7
Interventions:   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Fluorouracil;   Drug: Hydroxyurea;   Other: Laboratory Biomarker Analysis;   Drug: Paclitaxel;   Other: Placebo;   Radiation: Radiation Therapy;   Drug: Veliparib
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

Novel Cardiac Magnetic Resonance Imaging to Define a Unique Restrictive Cardiomyopathy in Sickle Cell Disease

Condition:   Sickle Cell Disease
Intervention:   Other: Cardiac magnetic resonance imaging (CMR)
Sponsor:   Children's Hospital Medical Center, Cincinnati
Completed

The Effect of On-Line Hemodiafiltration Versus High Flux Hemodialysis on Hemodynamic Parameters in Patients With Intra-Dialytic Hypotension

Condition:   Intradialytic Hypotension
Intervention:   Device: NICaS
Sponsor:   Western Galilee Hospital-Nahariya
Completed

EMBRACE (Evaluation of Maternal and Baby Outcome Registry After Chemoprophylactic Exposure)

Condition:   Pregnancy Related
Intervention:  
Sponsors:   Microbicide Trials Network;   National Institute of Allergy and Infectious Diseases (NIAID);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institutes of Health (NIH);   Gilead Sciences;   CONRAD
Recruiting

Characteristics of Patients With Type 2 Diabetes Mellitus (CVD-RNDR)

Condition:   Type 2 Diabetes
Intervention:  
Sponsor:   AstraZeneca
Completed

Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS)

Conditions:   Systemic Lupus Erythematosus;   Antiphospholipid Syndrome
Intervention:  
Sponsors:   Hospital for Special Surgery, New York;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting

Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese Women

Conditions:   Atherosclerosis;   Diabetes Mellitus;   Obesity;   Dyslipidemia;   Hypertension
Interventions:   Behavioral: Exercise;   Behavioral: Weight Loss
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

Conditions:   Healthy Volunteers and Subjects With Disease;   CAD
Interventions:   Device: MRI scan x 1- Healthy volunteer;   Device: MRI scan x 2- Healthy volunteer;   Device: MRI scan x 2- cardiac disease patients;   Device: MRI scan x 2- patients with non-cardiac disease
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

A Study Using Transorbital Alternating Current Stimulation for People With Glaucoma

Condition:   Glaucoma
Interventions:   Device: rtACS Stimulation;   Device: Sham Intervention
Sponsor:   NYU Langone Health
Recruiting

Clinical Evaluation of Visco-Assisted CyPass® Micro-Stent Implantation in Patients With Open Angle Glaucoma

Condition:   Open Angle Glaucoma
Interventions:   Device: CyPass Micro-Stent;   Device: Viscoelastic
Sponsor:   Transcend Medical, Inc.
Completed

Stop Retinal Ganglion Cell Dysfunction Study

Condition:   Glaucoma
Interventions:   Drug: Latanoprost;   Drug: Bimatoprost;   Drug: Travoprost;   Drug: Timolol;   Drug: Dorzolamide;   Drug: Brinzolamide;   Drug: Acetazolamide;   Drug: Methazolamide
Sponsors:   University of Miami;   National Eye Institute (NEI)
Recruiting

Clinical and Molecular Studies in Families With Glaucoma and Related Diseases

Condition:   Glaucoma
Intervention:  
Sponsor:   National Eye Institute (NEI)
Completed

FACT Biomarker Subgroup Analysis

Condition:   Pre-Eclampsia
Interventions:   Other: 4.0mg Folic Acid received through participation in FACT (NCT01355159);   Other: Placebo received through participation in FACT
Sponsor:   Ottawa Hospital Research Institute
Completed

Taxi STEP (Social Networks, Technology, and Exercise Through Pedometers)

Condition:   Physical Conditioning
Interventions:   Other: Health Fair;   Other: Pedometer;   Other: Text Messaging;   Other: Social Network Support
Sponsor:   Memorial Sloan Kettering Cancer Center
Recruiting

Study of the Efficacy and Safety of AMAG-423 (Digoxin Immune Fab) in Antepartum Subjects With Severe Preeclampsia

Condition:   Severe Preeclampsia
Interventions:   Biological: AMAG-423 (digoxin immune fab);   Other: Placebo
Sponsor:   AMAG Pharmaceuticals, Inc.
Recruiting

Pravastatin for Prevention of Preeclampsia

Condition:   Preeclampsia
Interventions:   Drug: Pravastatin;   Drug: Placebo
Sponsors:   The University of Texas Medical Branch, Galveston;   University of Pittsburgh;   Northwestern University;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting

Heart Function in Patients Assessed for Sleep Apnoea

Conditions:   Heart Failure With Preserved Ejection Fraction;   Sleep Disordered Breathing;   Heart Failure With Normal Ejection Fraction;   Obstructive Sleep Apnea;   Central Sleep Apnea;   Heart Failure
Intervention:  
Sponsors:   Imperial College London;   Royal Brompton & Harefield NHS Foundation Trust
Active, not recruiting

Kidney Coordinated Health Management Partnership

Condition:   Chronic Kidney Diseases
Interventions:   Other: Intervention Arm;   Other: Usual Care
Sponsors:   University of Pittsburgh;   Vanderbilt University Medical Center;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Enrolling by invitation

ICSI Versus Conventional IVF in Couples With Non-severe Male Infertility

Condition:   Male Infertility
Interventions:   Other: ICSI;   Other: Conventional IVF
Sponsors:   Jie Qiao;   International Peace Maternity and Child Health Hospital;   Women's Hospital School Of Medicine Zhejiang University;   Sixth Affiliated Hospital, Sun Yat-sen University;   The First Affiliated Hospital of Kunming Medical College;   Haidian Maternal and Child Health Hospital;   The First Affiliated Hospital of Anhui Medical University;   The Second Hospital of Hebei Medical University;   The Third Affiliated Hospital of Guangzhou Medical University;   General Hospital of Ningxia Medical University
Recruiting

Nailfold Capillary Blood Flow With Latanoprost Bunod

Condition:   Glaucoma, Open-Angle
Interventions:   Drug: Latanoprost 0.005%;   Drug: Latanoprost bunod 0.024%;   Drug: Normal saline 0.9%;   Diagnostic Test: Nailfold capillaroscopy
Sponsor:   Icahn School of Medicine at Mount Sinai
Not yet recruiting

Advanced MRI for Uteroplacental Flow, Perfusion, Oxygenation & Inflammation

Conditions:   Pregnancy;   Obesity;   Preeclampsia
Interventions:   Procedure: Ultrasound Scan;   Procedure: MRI Scan;   Drug: Ferumoxytol
Sponsors:   University of Wisconsin, Madison;   National Institutes of Health (NIH)
Recruiting

Safety and Efficacy Study of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-7902-006/E7080-G000-315/LEAP-006)

Condition:   Nonsquamous Non-small Cell Lung Cancer
Interventions:   Biological: Pembrolizumab;   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Pemetrexed;   Drug: Lenvatinib;   Drug: Placebo matching lenvatinib
Sponsors:   Merck Sharp & Dohme Corp.;   Eisai Inc.
Recruiting

Gestation Diabetes N'Teractive Media-based Education (GDnME)

Condition:   Gestational Diabetes
Intervention:   Other: Education
Sponsor:   Columbia University
Recruiting

EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality

Conditions:   Atrial Fibrillation;   Coronary Heart Disease;   Cardiovascular Diseases;   Heart Failure;   Hypertension;   Peripheral Arterial Disease;   Stroke, Ischemic;   Asthma;   Chronic Obstructive Pulmonary Disease;   Obesity;   Cancer;   Chronic Kidney Diseases;   Diabetes Mellitus;   Dementia;   Depression;   Epilepsy;   Mental Health Disorder;   Rheumatoid Arthritis;   Blood Pressure
Intervention:  
Sponsor:   Future Genetics Limited
Not yet recruiting

Controlled MAP Trauma Brain Injury (COMAT Study)

Condition:   Traumatic Brain Injury
Intervention:   Device: EV1000 and closed-loop system
Sponsors:   Assistance Publique - Hôpitaux de Paris;   University of California, Los Angeles;   University of California, Irvine
Not yet recruiting

Sedation Strategies for Therapeutic Bronchoscopy 2

Conditions:   Bronchoscopy;   Sedation
Interventions:   Drug: Dexmedetomidine;   Drug: Remifentanil;   Device: Laryngeal mask
Sponsors:   Changhai Hospital;   Shanghai Zhongshan Hospital;   Ruijin Hospital;   Shanghai Pulmonary Hospital, Shanghai, China
Not yet recruiting

Sedation Strategies for Therapeutic Bronchoscopy

Conditions:   Bronchoscopy;   Sedation
Interventions:   Drug: Dexmedetomidine;   Drug: Remifentanil;   Device: Laryngeal mask
Sponsors:   Changhai Hospital;   Shanghai Zhongshan Hospital;   Ruijin Hospital;   Shanghai Pulmonary Hospital, Shanghai, China
Terminated

Roxadustat in the Treatment of Anemia in Chronic Kidney Disease (CKD) Patients, Not on Dialysis, in Comparison to Darbepoetin Alfa

Condition:   Anemia in Chronic Kidney Disease in Non-dialysis Patients
Interventions:   Drug: Roxadustat;   Drug: darbepoetin alfa
Sponsors:   Astellas Pharma Europe B.V.;   FibroGen
Active, not recruiting

Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD

Condition:   Coronary Artery Disease
Interventions:   Drug: High dose potent statin;   Drug: ACE-I (lisinopril) or ARB (losartan);   Drug: Aspirin;   Behavioral: Lifestyle Counseling;   Behavioral: Quality of Life Questionnaires
Sponsors:   University of Florida;   United States Department of Defense
Recruiting

Study in Intensive Care Follow-up Programme in Improving Long-term Outcomes of ICU Survivors

Conditions:   Quality of Life;   Post ICU Discharge
Intervention:   Other: Medical, psychological, social
Sponsor:   Assistance Publique - Hôpitaux de Paris
Active, not recruiting

Hispanic Secondary Stroke Prevention Initiative

Condition:   Stroke
Interventions:   Behavioral: Community Health Worker (CHW);   Other: usual care and health education brochures every 4 months.
Sponsors:   University of Miami;   National Institute on Minority Health and Health Disparities (NIMHD)
Completed

KRX-0502 (Ferric Citrate) in Subjects With NDD-CKD and IDA (The COMPASS Trial)

Conditions:   Chronic Kidney Diseases;   Iron Deficiency Anemia
Intervention:   Drug: KRX-0502
Sponsor:   Keryx Biopharmaceuticals
Active, not recruiting

Supplemental Calcium in Overweight People

Condition:   Obesity
Interventions:   Drug: Calcium supplement;   Drug: Placebo
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   Office of Dietary Supplements (ODS)
Completed

Multi-parameters'Change Process During Dehydration Therapy on Brain Edema Patients.

Conditions:   Hemodynamic Instability;   Water on the Brain;   Intracranial Pressure Increase
Interventions:   Procedure: Mannitol injection;   Procedure: Hypertonic saline injection
Sponsors:   Ting Li;   Affiliated Hospital of Armed Police Logistics College
Not yet recruiting

Study to Evaluate the Efficacy of Tenapanor as Adjunctive Therapy to Phosphate Binder Therapy

Condition:   Hyperphosphatemia
Interventions:   Drug: Tenapanor;   Drug: Placebo
Sponsor:   Ardelyx
Active, not recruiting

Natural History of Sickle Cell Disease

Condition:   Pain Crisis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Endotracheal Tube Placement Using McGrath MAC® Video Laryngoscope Versus Macintosh Laryngoscope

Condition:   Intubation
Intervention:   Device: McGrath MAC® Video Laryngoscope
Sponsor:   Ohio State University
Withdrawn

Efficacy, Safety, and Tolerability of Selonsertib (GS-4997) in Participants With Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Selonsertib;   Drug: Placebo to match selonsertib
Sponsor:   Gilead Sciences
Completed

Integrating Risk-based Care for Patients With CKD

Condition:   Chronic Kidney Disease
Intervention:   Other: Active Knowledge Translation
Sponsors:   University of Manitoba;   Canadian Primary Care Sentinel Surveillance Network;   Canadians Seeking Solutions and Innovations to Overcome Chronic Kidney Disease
Recruiting

Abituzumab in SSc-ILD

Condition:   Systemic Sclerosis-associated Interstitial Lung Disease
Interventions:   Drug: Abituzumab 1500 mg;   Drug: Abituzumab 500 mg;   Drug: Placebo
Sponsors:   EMD Serono Research & Development Institute, Inc.;   Merck KGaA, Darmstadt, Germany
Terminated

Trial to Evaluate Reduction in Inflammation in Patients With Advanced Chronic Renal Disease Utilizing Antibody Mediated IL-6 Inhibition

Conditions:   Chronic Kidney Diseases;   Inflammation
Intervention:   Biological: Ziltivekimab
Sponsor:   Corvidia Therapeutics
Recruiting

A Phase 2 Trial of the Safety and Efficacy of Bardoxolone Methyl in Patients With Rare Chronic Kidney Diseases - PHOENIX

Conditions:   IgA Nephropathy;   CKD Associated With Type 1 Diabetes;   Focal Segmental Glomerulosclerosis;   Autosomal Dominant Polycystic Kidney
Intervention:   Drug: Bardoxolone methyl capsules
Sponsor:   Reata Pharmaceuticals, Inc.
Completed

Sedation Strategies for Diagnostic Bronchoscopy 2

Conditions:   Bronchoscopy;   Sedation
Interventions:   Drug: Midazolam;   Drug: Fentanyl;   Drug: Dexmedetomidine;   Drug: Remifentanil;   Drug: Propofol
Sponsors:   Changhai Hospital;   Shanghai Zhongshan Hospital;   Ruijin Hospital;   Shanghai Pulmonary Hospital, Shanghai, China
Not yet recruiting

Sedation Strategies for Diagnostic Bronchoscopy

Conditions:   Bronchoscopy;   Sedation
Interventions:   Drug: Midazolam;   Drug: Dexmedetomidine;   Drug: Remifentanil;   Drug: Fentanyl;   Drug: Propofol
Sponsors:   Changhai Hospital;   Shanghai Zhongshan Hospital;   Ruijin Hospital;   Shanghai Pulmonary Hospital, Shanghai, China
Terminated

Follow up Study to Assess Long Term Safety and Outcomes in Infants and Children Born to Mothers Participating in Retosiban Treatment Studies

Condition:   Obstetric Labour, Premature
Interventions:   Drug: Retosiban;   Drug: Atosiban;   Drug: Placebo
Sponsors:   GlaxoSmithKline;   PPD
Active, not recruiting

A Study to Assess the Efficacy and Safety of Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)

Condition:   Duchenne Muscular Dystrophy
Interventions:   Drug: Vamorolone;   Drug: Prednisone;   Other: Placebo
Sponsors:   ReveraGen BioPharma, Inc.;   European Union;   Cooperative International Neuromuscular Research Group;   Newcastle University;   University of Pittsburgh
Recruiting

SweetMama: Testing of a Novel Technology for Diabetes Education and Support to Pregnant Women

Condition:   Diabetes Mellitus in Pregnancy
Interventions:   Behavioral: SweetMama Focus Groups;   Behavioral: SweetMama Individual Testing;   Behavioral: SweetMama Feasibility Testing - Pilot Randomized Trial
Sponsor:   Northwestern University
Recruiting

Lifestyle Intervention for Women With Recent Pre-eclampsia or Gestational Diabetes Mellitus ('Mom's Healthy Heart')

Conditions:   Pre-Eclampsia;   Gestational Diabetes
Intervention:   Behavioral: Web-based lifestyle intervention
Sponsors:   Norwegian University of Science and Technology;   Harvard Medical School;   University of Oslo
Not yet recruiting

Study of Sotatercept for the Treatment of Anemia in low-or Intermediate-1 Risk Myelodysplastic Syndromes (MDS) or Non-proliferative Chronic Myelomonocytic Leukemia (CMML)

Conditions:   Anemia;   Myelodysplastic Syndromes;   Chronic Myelomonocytic Leukemia;   Low to Intermediate-1 MDS;   Myelodysplastic Syndromes (MDS);   Chronic Myelomonocytic Leukemia (CMML)
Intervention:   Drug: Sotatercept
Sponsor:   Celgene
Completed

End-stage Renal Disease (ESRD) Pilot Study

Condition:   Renal Dialysis
Interventions:   Drug: BAY1213790;   Drug: 0.9% sodium chloride solution
Sponsor:   Bayer
Recruiting

A Trial to Evaluate the Efficacy of PRM-151 in Subjects With Idiopathic Pulmonary Fibrosis (IPF)

Condition:   Idiopathic Pulmonary Fibrosis
Interventions:   Biological: PRM-151;   Other: placebo
Sponsor:   Promedior, Inc.
Active, not recruiting

Comparison of the Human Acellular Vessel (HAV) With Fistulas as Conduits for Hemodialysis

Conditions:   Renal Failure;   End Stage Renal Disease;   Hemodialysis;   Vascular Access
Interventions:   Biological: Human Acellular Vessel (HAV);   Procedure: Arteriovenous fistula (AVF)
Sponsors:   Humacyte, Inc.;   CTI Clinical Trial and Consulting Services;   California Institute for Regenerative Medicine (CIRM)
Recruiting

EMPA-KIDNEY (The Study of Heart and Kidney Protection With Empagliflozin)

Condition:   Chronic Kidney Disease
Interventions:   Drug: Empagliflozin;   Drug: Matching placebo
Sponsors:   Boehringer Ingelheim;   Medical Research Council Population Health Research Unit, CTSU, University of Oxford (academic lead);   Eli Lilly and Company
Recruiting

EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)

Condition:   Heart Failure
Interventions:   Drug: Empagliflozin;   Drug: Placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting

EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)

Condition:   Heart Failure
Interventions:   Drug: Empagliflozin;   Drug: Placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting

Safety and Efficacy Study of IFX-1 in add-on to Standard of Care in Granulomatosis With Polyangiitis (GPA) and Microscopic Polyangiitis (MPA)

Conditions:   Granulomatosis With Polyangiitis (GPA);   Microscopic Polyangiitis (MPA)
Interventions:   Drug: IFX-1;   Drug: Placebo
Sponsors:   InflaRx GmbH;   IQVIA
Recruiting

XperGuide in Sacroiliac Joint Injection

Conditions:   Sacroiliitis;   Sacroiliac Joint Pain
Intervention:   Other: sacroiliac joint injection
Sponsors:   University of Washington;   Philips Medical Systems
Not yet recruiting

Two-dimensional Shear-Wave Elastography Evaluate Esophageal Varices Bleeding Risk of Liver Cirrhosis

Conditions:   Liver Cirrhosis;   Esophageal Varices;   Liver Stiffness
Intervention:   Diagnostic Test: Gastroscopy
Sponsor:   West China Hospital
Recruiting

The MODE Trial: Planned Caesarean Section Versus Induction of Labour for Women With Class III Obesity

Conditions:   Obesity Complicating Childbirth;   Obesity;   Labor Onset and Length Abnormalities;   Pregnancy, High Risk;   Cesarean Section Complications
Interventions:   Procedure: Caesarean section;   Procedure: Induction of Labour
Sponsors:   Ottawa Hospital Research Institute;   Canadian Institutes of Health Research (CIHR)
Not yet recruiting

Study of the Retinal Vascularization by Laser Doppler Velocimetry Coupled With an Adaptive Optics Camera ( AO-LDV)

Conditions:   Glaucoma;   Retinal Vein Occlusion
Intervention:   Procedure: Laser Doppler Velocimetry + Optic Adaptative Camera
Sponsor:   University Hospital, Grenoble
Recruiting

Forearm Blood Flow in Chronic Kidney Disease Subjects With Anemia (FBF-CKD)

Condition:   Anaemia
Interventions:   Drug: Daprodustat;   Drug: Darbepoetin alfa (Aranesp);   Drug: Acetylcholine;   Drug: Sodium nitroprusside;   Drug: L-N-monomethyl arginine citrate (L-NMMA)
Sponsor:   GlaxoSmithKline
Recruiting

The Cryopreserved vs. Liquid Platelets Trial

Conditions:   Surgical Blood Loss;   Hemorrhage
Interventions:   Biological: Cryopreserved platelets;   Biological: Liquid-stored platelets
Sponsors:   Australian and New Zealand Intensive Care Research Centre;   Australian Red Cross
Not yet recruiting