High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

The Diurnal and Nocturnal Effect of Pilocarpine on Intraocular Pressure and Ocular Perfusion Pressure

Conditions:   Glaucoma, Open-angle;   Hypertension, Ocular
Intervention:   Drug: Pilocarpine
Sponsor:   University of Colorado, Denver
Not yet recruiting - verified April 2016

N-of-1 Trials for Blood Pressure Medications in Adults

Conditions:   Hypertension;   High Blood Pressure
Interventions:   Drug: Losartan;   Drug: Amlodipine;   Drug: Hydrochlorothiazide
Sponsor:   Columbia University
Recruiting - verified April 2016

Zambia One Love Aim 3 Trial

Conditions:   HIV;   Sexually Transmitted Diseases;   Neglected Diseases;   Non-communicable Diseases
Interventions:   Behavioral: Strengthening Our Vows (SOV);   Behavioral: Good Health Package Plus (GHPP)
Sponsor:   Emory University
Recruiting - verified April 2016

Influence of Conditional Workout Postpartum on Arterial Stiffness Among Women With Status After Preeclampsia, Superimposed Preeclampsia or HELLP-syndrome

Conditions:   Preeclampsia;   Superimposed Preeclampsia;   HELLP Syndrome
Intervention:   Behavioral: conditional workout
Sponsor:   Martin-Luther-Universität Halle-Wittenberg
Recruiting - verified April 2016

Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders

Conditions:   Lung Transplant;   Lung Resection;   Lung Cancer;   Asthma;   Cystic Fibrosis;   Chronic Obstructive Pulmonary Disease;   Emphysema;   Mesothelioma;   Asbestosis;   Pulmonary Embolism;   Interstitial Lung Disease;   Pulmonary Fibrosis;   Bronchiectasis;   Seasonal Allergies;   Cold Virus;   Lung Infection;   Pulmonary Hypertension;   Pulmonary Dysplasia;   Obstructive Sleep Apnea
Interventions:   Drug: HP 3He;   Drug: HP 129Xe;   Drug: PFP;   Drug: SF6;   Device: 129Xe Small and Large Human Lung Coil;   Device: 3He Human Lung Coil;   Device: PFP and SF6 Human Lung Coil
Sponsors:   Thunder Bay Regional Research Institute;   Thunder Bay Regional Health Sciences Centre;   St. Joseph's Care Group;   Lakehead University
Not yet recruiting - verified April 2016

Six Minutes Walk Test and Shuttle Walk Test in Eisenmenger Syndrome

Conditions:   Eisenmenger Complex;   Pulmonary Hypertension;   Congenital Heart Defects
Intervention:  
Sponsor:   Federal University of São Paulo
Recruiting - verified April 2016

Dexmedetomidine on Optic Nerve Sheath Diameter

Condition:   Intracranial Hypertension
Interventions:   Drug: Dexmedetomidine;   Drug: normal saline
Sponsor:   Gachon University Gil Medical Center
Not yet recruiting - verified April 2016

Effectiveness of Inspiratory Muscle Training With Slow Breathing in Elderly With ISH

Condition:   Hypertension
Interventions:   Other: Inspiratory Muscle Training;   Other: Control
Sponsor:   Khon Kaen University
Recruiting - verified April 2016

Effects of the TNF-alpha Inhibiton on Hemodynamic Parameters in Resistant Hypertension

Condition:   Hypertension
Interventions:   Biological: Infliximab;   Other: Saline
Sponsor:   University of Campinas, Brazil
Recruiting - verified April 2016

Comparison of Three Combination Therapies in Lowering Blood Pressure in Black Africans

Condition:   Hypertension
Interventions:   Drug: Perindopril plus Amlodipine;   Drug: Perindopril plus Hydrochlorothiazide;   Drug: Amlodipine plus Hydrochlorothiazide
Sponsors:   University of Abuja;   Imperial College London;   University of Cape Town;   Hôpital Edouard Herriot;   University of Nairobi;   University of Ibadan;   Hospital General De Douala;   Mulago Hospital, Uganda
Not yet recruiting - verified April 2016

Interventional Treatment of Residual Pulmonary Hypertension in Patients After Pulmonary Thromboendarterectomy

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Interventions:   Procedure: Radiofrequency pulmonary artery denervation;   Device: Ablation catheter;   Device: Swan-Ganz catheter for right heart catheterization
Sponsor:   Novosibirsk Scientific Research Institute for Circulatory Pathology
Recruiting - verified April 2016

Efficacy and Safety of Endoscopic Variceal Ligation (EVL) Versus EVL Plus Non-selective B-blockers (NSBB) For Prevention of Variceal Rebleed and Non-bleed Related Complications in Patients With Advanced Cirrhosis

Condition:   Advanced Cirrhosis
Interventions:   Procedure: Endoscopic Variceal Ligation;   Drug: Non selective beta blocker;   Other: Placebo
Sponsor:   Institute of Liver and Biliary Sciences, India
Recruiting - verified April 2016

Effects of Empagliflozin + Linagliptin vs Metformin + Insulin Glargine on Renal and Vascular Changes in Type 2 Diabetes

Condition:   Diabetes Mellitus Type 2
Interventions:   Drug: Empagliflozin and Linagliptin;   Drug: Metformin and Insulin sc
Sponsors:   Institut für Pharmakologie und Präventive Medizin;   University of Erlangen-Nürnberg Medical School
Recruiting - verified April 2016

Pilot - Peri-operative Beta Blockade

Conditions:   Adrenergic Beta-Receptor Blockader;   Troponin Levels;   Cardiomyopathy, Post-surgical
Intervention:   Drug: metoprolol
Sponsor:   Washington University School of Medicine
Recruiting - verified April 2016

Health Impacts of a Climate Change Adaptation Strategy to Address Drinking-water Salinity in Coastal Bangladesh

Condition:   Hypertension
Intervention:   Other: Managed Aquifer Recharge water
Sponsors:   International Centre for Diarrhoeal Disease Research, Bangladesh;   University of Dhaka;   University College, London;   Emory University
Not yet recruiting - verified April 2016

Biobank on Prematurity, Preeclampsia and Other Pregnancy Complications

Condition:   Preeclampsia, Preterm Birth, Pregnancy Complications
Intervention:   Other: Observational
Sponsor:   Centre Hospitalier Universitaire de Québec, CHU de Québec
Recruiting - verified April 2016

Carefully seLected and Easily Accessible at No Charge Medications

Conditions:   Medication Adherence;   Inappropriate Prescribing;   Diabetes;   Hypertension
Intervention:   Other: Free and convenient medicine access
Sponsors:   St. Michael's Hospital, Toronto;   Ontario SPOR SUPPORT UNIT
Not yet recruiting - verified April 2016

Endtidal Ethanol in Sclerotherapy

Condition:   Ethanol Concentration
Intervention:   Device: Alcomed 3011®
Sponsor:   University Hospital Inselspital, Berne
Not yet recruiting - verified April 2016

Acute Hemodynamic Effect of Acetazolamide in Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Interventions:   Drug: Acetazolamide;   Drug: Placebo
Sponsor:   University of Zurich
Not yet recruiting - verified April 2016

Clinical Trial to Compare the Pharmacokinetics of TAH Tablet in Comparison to the Co-administration of Telmisartan, Amlodipine and Hydrochlorothiazide in Healthy Male Volunteers

Condition:   Essential Hypertension
Interventions:   Drug: TAH Tablet (Telmisartan/Amlodipine besylate/Hydrochlorothiazide);   Drug: TWYNSTA(Telmisartan+Amlodipine besylate);   Drug: Hydrochlorothiazide
Sponsor:   IlDong Pharmaceutical Co Ltd
Active, not recruiting - verified April 2016

The Role of Values, Acceptance, and Mindfulness Strategies in Long Term Weight Management

Condition:   Obesity
Intervention:   Behavioral: Acceptance and Commitment Therapy
Sponsor:   Nova Scotia Health Authority
Not yet recruiting - verified April 2016

Chronic Clinical Effect of Acetazolamide

Condition:   Hypertension, Pulmonary
Interventions:   Drug: Acetazolamide;   Drug: Placebo
Sponsor:   University of Zurich
Not yet recruiting - verified April 2016

Pharmacodynamic Effects of Riociguat in Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction

Conditions:   Hypertension, Pulmonary;   Heart Failure With Normal Ejection Fraction
Interventions:   Drug: Riociguat;   Drug: Placebo
Sponsor:   Medical University of Vienna
Recruiting - verified April 2016

Point-of-Care Adipose-derived Cells for Hair Growth

Condition:   Androgenetic Alopecia
Interventions:   Procedure: Stromal Vascular Fraction Cells (SVF Cells) Injection;   Procedure: Liposuction;   Other: Hair Measurements
Sponsor:   University of Florida
Not yet recruiting - verified April 2016

Evaluation to Assess Cognitive Training for the Prevention of Post-operative Cognitive Decline

Condition:   Cognitive Dysfunction
Intervention:   Behavioral: Cognitive training program RehaCom®
Sponsor:   Charite University, Berlin, Germany
Not yet recruiting - verified April 2016

Single and Multiple Ascending Doses Clinical Pharmacology Study With KAR5585

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: KAR5585 Capsules;   Drug: Placebo Capsules
Sponsor:   Karos Pharmaceuticals
Active, not recruiting - verified April 2016

PDA Post NICU Discharge

Condition:   Patent Ductus Arteriosus
Intervention:  
Sponsor:   Mednax Center for Research, Education and Quality
Not yet recruiting - verified April 2016

SToRytelling to Improve DiseasE Outcomes in GOut: The STRIDE-GO 2 Study

Conditions:   Gout;   Low Medication Adherence;   Health Related Quality of Life
Intervention:   Behavioral: Improvement of Medication Adherence
Sponsor:   VA Office of Research and Development
Not yet recruiting - verified April 2016

Study Comparing Travoprost Intraocular Implants to Timolol Ophthalmic Solution

Condition:   Glaucoma Open-angle
Interventions:   Drug: Travoprost Intraocular Implant, high elution;   Drug: Travoprost Intraocular Implant, low elution;   Drug: Timolol Maleate Ophthalmic Solution, 0.5%
Sponsor:   Glaukos Corporation
Recruiting - verified April 2016

WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study)

Conditions:   Williams Syndrome;   Cardiovascular Disease;   Multisystem Developmental Disorder;   Elastin Gene Deletion;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified February 2016

Induction Versus Expectant Management With Abnormal Maternal Biochemical Markers

Condition:   PREGNANCY
Interventions:   Other: Induction of labour;   Other: Expectant management
Sponsor:   HaEmek Medical Center, Israel
Active, not recruiting - verified April 2016

Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic

Conditions:   Multiple System Atrophy;   Orthostatic Hypotension;   Supine Hypertension
Interventions:   Drug: Trimethaphan;   Drug: Placebo
Sponsor:   Vanderbilt University
Recruiting - verified April 2016

Mitomycin C Trabeculectomy Trial for Glaucoma in Ethiopia

Condition:   Glaucoma
Intervention:   Drug: Mitomycin-C (MMC)
Sponsors:   Francis I. Proctor Foundation;   Menelik II Hospital
Recruiting - verified April 2016

Pre-eclampsia and Biochemical Markers

Condition:   Detection of Preeclampsia Complications
Intervention:  
Sponsor:   Assiut University
Recruiting - verified January 2016

A Study of the ReCor Medical Paradise System in Clinical Hypertension

Conditions:   Hypertension;   Vascular Diseases
Interventions:   Device: The Paradise® Renal Denervation Ultrasound System;   Device: Sham Procedure
Sponsor:   ReCor Medical, Inc.
Recruiting - verified March 2016

Phase II Study of Perindopril and Regorafenib in mCRC

Condition:   Metastatic Colorectal Cancer
Interventions:   Drug: Regorafenib;   Drug: Perindopril
Sponsors:   British Columbia Cancer Agency;   Bayer
Not yet recruiting - verified April 2016

Risk Factors Related to Metabolic Syndrome in School-aged Children Who Were Born Preterm

Condition:   Metabolic Syndrome
Intervention:   Other: Preterm/term cohort
Sponsor:   Seoul National University Hospital
Recruiting - verified April 2016

Early Detection of Pulmonary- and Pulmonary Vascular Disease in Sjögren Syndrome

Conditions:   Sjögren Syndrome;   Pulmonary Hypertension
Intervention:  
Sponsor:   Medical University of Graz
Recruiting - verified April 2016

Effects of Polyphenols Found in Pomegranate Juice on Postprandial Blood Glucose in Vivo

Condition:   Hyperglycaemia
Interventions:   Other: Control without pomegranate juice;   Other: Test with pomegranate juice
Sponsor:   University of Leeds
Completed - verified April 2016

Surgical Intervention for the Treatment of Diabetes in Overweight Non-responders-1

Conditions:   Overweight;   Diabetes Mellitus, Type 2
Interventions:   Procedure: Sleeve Gastrectomy with Ileal Transposition;   Procedure: Sleeve Gastrectomy with Transit Bipartition;   Other: Medical Treatment
Sponsor:   Turkish Metabolic Surgery Foundation
Enrolling by invitation - verified April 2016

Genetic and Environmental Determinants That Control Metabolism in Pulmonary Hypertension

Conditions:   Iron-sulfur Cluster Deficiency;   Pulmonary Hypertension
Intervention:  
Sponsor:   University of Pittsburgh
Recruiting - verified April 2016

Open Label Extension of LipoLat-CS202

Condition:   Glaucoma
Intervention:   Other: None in this study
Sponsor:   Peregrine Ophthalmic
Active, not recruiting - verified April 2016

A Cross-sectional Study for the Determination of the Prevalence of Non-valvular Atrial Fibrillation Among Patients Diagnosed With Hypertension

Conditions:   Hypertension;   Atrial Fibrillation
Intervention:   Other: Standard of care
Sponsor:   Bayer
Active, not recruiting - verified April 2016

CKD-330 Phase 3 Trial in Amlodipine Non-responder

Condition:   Hypertension
Interventions:   Drug: CKD-330 16/5mg;   Drug: Amlodipine 5mg Placebo;   Drug: CKD-330 16/5mg Placebo;   Drug: Amlodipine 5mg
Sponsor:   Chong Kun Dang Pharmaceutical
Recruiting - verified April 2016

Acute Effects of rhBNP in Patients With PH Associated With Acute Exacerbation of Chronic Pulmonary Disease

Condition:   Pulmonary Hypertension
Interventions:   Drug: rhBNP;   Drug: placebo
Sponsor:   LI ZHAO
Recruiting - verified April 2016

Accuracy of 1.5 T Versus 3 T Magnetic Resonance Arterial Spin Labeling to Measure Renal Blood Flow

Conditions:   Hypertension;   Chronic Kidney Disease
Intervention:   Other: renal perfusion
Sponsor:   University of Erlangen-Nürnberg Medical School
Recruiting - verified April 2016

Carbidopa for the Treatment of Excessive Blood Pressure Variability

Conditions:   Dysautonomia, Familial;   Baroreflex Failure Syndrome
Interventions:   Drug: Carbidopa Low Dose;   Other: Placebo;   Drug: Carbidopa High Dose
Sponsors:   New York University School of Medicine;   FDA Office of Orphan Products Development
Recruiting - verified April 2016

Sleep Deficiency and Stroke Outcome

Conditions:   Sleep Apnea Syndromes;   Sleep Initiation and Maintenance Disorders;   Insomnia;   Restless Legs Syndrome;   Stroke
Intervention:  
Sponsors:   University Hospital Inselspital, Berne;   Neurocenter of Southern Switzerland;   Swiss Heart Foundation
Recruiting - verified April 2016

An Observational Cross-sectional Study Evaluating the Use of Re-sources and the Sociodemographic and Clinical Characteristics of Patients Diagnosed With Non-valvular Atrial Fibrillation With a Risk of Stroke or Systemic Embolism on Anticoagulant Therapy and Treated in Primary Care Centers

Conditions:   Stroke;   Prevention and Control;   Atrial Fibrillation
Intervention:   Drug: Xarelto, Pradaxa and Eliquis
Sponsor:   Bayer
Active, not recruiting - verified April 2016

Effect of Vitamin C on Postoperative Pain After Laparoscopic Cholecystectomy

Conditions:   Chronic Cholecystitis;   Cholelithiasis
Interventions:   Drug: Vitamin C;   Drug: Placebo
Sponsor:   Seoul St. Mary's Hospital
Recruiting - verified September 2015

28-Day Repeated Topical Study to Evaluate the Safety and Activity of 5 Escalating Dose Levels of SAR366234 and One Dose of Latanoprost in Patients With Open Angle Glaucoma or Ocular Hypertension

Condition:   Open Angle Glaucoma -Ocular Hypertension
Interventions:   Drug: Latanoprost;   Drug: SAR366234
Sponsor:   Sanofi
Completed - verified April 2016

Efficacy of a Telmisartan/S-Amlodipine on 24-hour BP Control in Hypertensive Patients Inadequately Controlled

Condition:   Hypertension
Intervention:   Drug: Telminuvo®Tab. 40/2.5mg
Sponsor:   Chong Kun Dang Pharmaceutical
Recruiting - verified April 2016

Effectiveness of Vitamin D Supplementation

Conditions:   Elevated Blood Pressure;   Endothelial Dysfunction
Intervention:   Dietary Supplement: 2,000 International Units (IU)of vitamin D3
Sponsors:   Texas Woman's University;   The Methodist Hospital System
Recruiting - verified April 2016

Associations of Vitamin D Deficiency and Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma

Conditions:   Vitamin D Deficiency;   Primary Open- Angle Glaucoma
Interventions:   Other: Vitamin D receptor polymorphic analysis;   Other: Serum levels of 1a, 25-Dihydroxyvitamin D3
Sponsor:   Lv Yingjuan
Completed - verified April 2016

Early Sleeve Gastrectomy In New Onset Diabetic Obese Patients

Condition:   Type 2 Diabetes Mellitus
Interventions:   Procedure: LSG;   Drug: CMT
Sponsors:   Azienda Ospedaliera Santa Maria, Terni, Italy;   Ethicon Endo-Surgery
Recruiting - verified April 2016

Clinical Trial to Evaluation the Safety and Efficacy of GR-MD-02 for the Treatment of Liver Fibrosis and Resultant Portal Hypertension in Patients With Nash Cirrhosis

Condition:   Hypertension, Portal
Interventions:   Drug: GR-MD-02;   Drug: Placebo
Sponsors:   Galectin Therapeutics Inc.;   Brooke Army Medical Center, Stephen A. Harrison, MD;   Indiana University, Naga Chalasani, MD
Recruiting - verified March 2016

POLAT-001 Compared to Latanoprost Ophthalmic Solution in Patients With Ocular Hypertension and Open-angle Glaucoma

Condition:   Glaucoma
Interventions:   Drug: POLAT-001;   Drug: Latanoprost ophthalmic solution
Sponsor:   Peregrine Ophthalmic
Completed - verified April 2016

Effects of Polyphenols Found in Pomegranate and Olives Food Supplements on Postprandial Blood Glucose in Vivo.

Condition:   Hyperglycaemia
Interventions:   Other: Control (109 g white bread);   Dietary Supplement: Dose 1;   Dietary Supplement: Dose 2
Sponsor:   University of Leeds
Completed - verified April 2016

Analysis of CRBSI Rates in Patients With a NexSite™ HD (Hemodialysis) Catheter

Condition:   End Stage Renal Disease
Intervention:   Device: NexSite HD Patients
Sponsor:   Marvao Medical
Recruiting - verified April 2016

Prospective, Non-interventional, Multi-center, Post-authorization Safety Study of Riociguat for Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Recruiting - verified April 2016

Local Heat Stress in Autonomic Failure Patients With Supine Hypertension

Conditions:   Hypertension;   Pure Autonomic Failure;   Multiple System Atrophy;   Autonomic Failure
Interventions:   Other: Passive heat stress;   Other: Control (non-heating)
Sponsor:   Vanderbilt University
Recruiting - verified April 2016

Observational Study to Evaluate the Safety and Efficacy for Levacalm Tab. Versus Valsartan/Amlodipine Combination Therapy in Essential Hypertension Patients

Conditions:   Lower Leg Edema;   Orthostatic Hypertension
Interventions:   Drug: Levacalm;   Drug: Valsartan/amlodipine
Sponsor:   LG Life Sciences
Recruiting - verified April 2016

Is MyPlate Approach to Helping Overweight Patients Lose Weight More Patient-centered?

Condition:   Obesity
Interventions:   Behavioral: Calorie-counting;   Behavioral: MyPlate
Sponsors:   University of California, Los Angeles;   Patient-Centered Outcomes Research Institute
Active, not recruiting - verified April 2016

Magnetic Resonance Venography Pre- and Post-Treatment in Patients With Idiopathic Intracranial Hypertension

Condition:   Pseudotumor Cerebri
Intervention:   Other: Radiological Imaging
Sponsor:   Jai Shankar
Not yet recruiting - verified April 2016

Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B

Condition:   Healthy
Interventions:   Drug: Celecoxib;   Drug: Placebo
Sponsors:   University of Pennsylvania;   Eli Lilly and Company
Completed - verified April 2016

Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients

Condition:   Glaucoma, Neovascular
Interventions:   Drug: Aflibercept (Eylea, BAY 86-5321);   Drug: Sham Injection
Sponsors:   Bayer;   Regeneron Pharmaceuticals
Recruiting - verified April 2016

Pre-Eclampsia And Growth Restriction: a Longitudinal Study

Conditions:   Preeclampsia;   Severe Preeclampsia;   Fetal Growth Restriction;   Preterm Birth
Intervention:  
Sponsors:   Centre Hospitalier Universitaire de Québec, CHU de Québec;   Jeanne-et-Jean-Louis-Lévesque Chair;   Laval University
Recruiting - verified April 2016

PDEI Following Mitral Valve Surgery in Patients With Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Mitral Valve Surgery
Interventions:   Drug: Sildenafil;   Drug: Placebo
Sponsor:   Dr. Robert Klempfner Heart Rehabilitation Institute
Recruiting - verified April 2016

Impact of an Interprofessional Shared Decision-making and Goal-setting Decision Aid for Patients With Diabetes

Condition:   Diabetes Mellitus
Interventions:   Other: Shared decision-making aid;   Other: Generic hard copy diabetes resources;   Other: Generic online diabetes resources
Sponsors:   St. Michael's Hospital, Toronto;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting - verified April 2016

Clinical Trial to Evaluate the Long-term Safety of Udenafil in Patient With PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Udenafil
Sponsor:   Dong-A ST Co., Ltd.
Completed - verified April 2016

Pharmacogenetic Prediction of Metoprolol Effectiveness

Condition:   Hypertension
Interventions:   Drug: metoprolol succinate;   Genetic: Genotyping;   Procedure: CYP2D6 Phenotyping
Sponsors:   University of Colorado, Denver;   National Institute of General Medical Sciences (NIGMS)
Recruiting - verified April 2016

A Phase 4 Study of Regorafenib in Metastatic Colorectal Cancer - Does Educating Physicians Change Patient Out Comes?

Condition:   Physician Education
Intervention:   Drug: Regorafenib (Stivarga, BAY 73-4506)
Sponsor:   Bayer
Completed - verified April 2016

Randomized Clinical Trial; Medical vs Bariatric Surgery for Adolescents (13-16 y) With Severe Obesity

Conditions:   Obesity;   Diabetes;   Hypertension;   Steatohepatitis;   Inflammation
Interventions:   Procedure: Laparoscopic Roux-en-Y gastric bypass;   Procedure: Intense conservative treatment
Sponsors:   Göteborg University;   Sahlgrenska University Hospital, Sweden;   Karolinska University Hospital;   Lund University
Recruiting - verified April 2016

Exercise Behavior Among Young Adults Study

Condition:   Physical Activity
Interventions:   Other: Exercise info;   Other: Implementation intentions;   Other: Industriousness;   Device: pedometer
Sponsor:   Wayne State University
Active, not recruiting - verified April 2016

Telehealth Self-Management Program in Older Adults Living With Heart Failure in Health Disparity Communities

Condition:   Chronic Heart Failure
Interventions:   Device: Telehealth Self Management (TSM);   Other: Standard of Care
Sponsor:   Northwell Health
Recruiting - verified April 2016

24 Week Efficacy and Safety Study of Empagliflozin (BI 10773) in Hypertensive Black/African American Patients With Type 2 Diabetes Mellitus and Hypertension

Conditions:   Diabetes Mellitus, Type 2;   Hypertension
Interventions:   Drug: Empagliflizon low dose;   Drug: placebo;   Drug: Empagliflizon high dose
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified April 2016

Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis (MIRACULOUS) Trial

Condition:   Atherosclerosis
Interventions:   Drug: Eplerenone;   Drug: Placebo
Sponsor:   University of Maryland
Recruiting - verified April 2016

Ocular Blood Flow Assessment in Glaucoma

Condition:   Glaucoma
Intervention:   Other: Flow imaging
Sponsor:   Centre Hospitalier Universitaire, Amiens
Recruiting - verified April 2016

Reducing Obesity Among Public Housing Residents: an Ecological Approach

Conditions:   Overweight and Obesity;   Hypertension
Intervention:   Behavioral: Social network intervention
Sponsors:   Johns Hopkins University;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified April 2016

Healing and Empowering Alaskan Lives Towards Healthy-Hearts Study

Condition:   Tobacco Dependence
Interventions:   Behavioral: Tobacco/Physical Activity Intervention;   Behavioral: Diet plus BP/CHOL Intervention
Sponsors:   Stanford University;   University of California, San Francisco;   Alaska Native Tribal Health Consortium;   University of Alaska Anchorage;   Norton Sound Health Corporation
Recruiting - verified April 2016

Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Recruiting - verified April 2016

Comorbidities and Virologic Outcome Among Patients on Anti-retroviral Therapy in Rural Lesotho

Conditions:   HIV;   Metabolic Syndrome;   Depression;   Alcoholism;   Hepatitis
Intervention:  
Sponsors:   Swiss Tropical & Public Health Institute;   Swiss Foundation for Excellence and Talent in Biomedical Research;   SolidarMed - Swiss Organization for Health in Africa;   University of Basel;   Central Laboratories, University Hospitals Basel-Land (Liestal)
Completed - verified April 2016

EXPERT, EXPosurE Registry RiociguaT in Patients With Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat(BAY63-2521)
Sponsor:   Bayer
Recruiting - verified April 2016

Evaluation of the Samsung LABGEO IVD-A20 CHF Test in a Point-of-Care Setting

Condition:   Congestive Heart Failure
Intervention:   Device: Samsung LABGEO IVD-A20 CHF Test
Sponsors:   Samsung Electronics;   Nexus-Dx
Terminated - verified February 2015

Lipidomics Screening of Anti-inflammatory Drugs and Drug Candidates in Vitro - Part A

Condition:   Healthy
Intervention:   Procedure: None, a blood draw
Sponsors:   University of Pennsylvania;   Eli Lilly and Company
Recruiting - verified April 2016

Outcomes of Angiotensin Converting Enzyme Inhibitor Management Strategies Prior to Coronary Artery Bypass

Condition:   Coronary Artery Disease
Interventions:   Drug: ACE/ARB continuation;   Drug: ACE/ARB withdrawal
Sponsor:   University of Alberta
Recruiting - verified April 2016

Evaluation of 3D Overlay During Transjugular Intrahepatic Portosystemic Shunt (TIPS) Procedure

Condition:   Portal Hypertension
Intervention:   Procedure: TIPS with 3D Overlay
Sponsors:   Medical College of Wisconsin;   Siemens Medical Solutions
Enrolling by invitation - verified April 2016

Low-dose Colchicine in Patients With Type 2 Diabetes Mellitus and Microalbuminuria

Condition:   Diabetic Nephropathy
Interventions:   Drug: colchicine 0.5mg/d;   Drug: placebo 0.5mg/d
Sponsor:   Chongqing Medical University
Active, not recruiting - verified April 2016

Individually Tailored Treatment of Type 2 Diabetes

Conditions:   Type 2 Diabetes;   Hypertension
Intervention:   Other: Individual treatment
Sponsors:   Odense University Hospital;   Region of Southern Denmark;   Hospital of South West Denmark;   General Practice Research Database
Enrolling by invitation - verified April 2016

Alpha-1 Antitrypsin Deficiency Adult Liver Study

Condition:   Alpha-1 Antitrypsin Deficiency
Intervention:   Procedure: Liver Biopsy
Sponsors:   St. Louis University;   Alpha-1 Foundation;   University of California;   Boston University;   University College, London;   University of Massachusetts, Worcester
Recruiting - verified April 2016

BNP Pharmacodynamics and Effects on Metabolism in Lean and Obese Subjects

Conditions:   Obesity;   Cardiovascular Disease;   Hypertension;   Diabetes
Interventions:   Drug: Nesiritide;   Drug: Saline
Sponsors:   Translational Research Institute for Metabolism and Diabetes, Florida;   Sanford-Burnham Medical Research Institute
Active, not recruiting - verified April 2016

Abiraterone Acetate for Castrate Resistant Prostate Cancer

Condition:   Prostate Cancer
Interventions:   Drug: Abiraterone;   Drug: Prednisone
Sponsor:   Massachusetts General Hospital
Recruiting - verified April 2016

Pharmacokinetics, Pharmacodynamics and Safety of DEB025 Plus Ribavirin in Chronic Hepatitis C Genotype 2 and 3 Treatment naïve Patients

Conditions:   Hepatitis C;   Liver Disease
Interventions:   Drug: Alisporivir;   Drug: Ribavirin;   Drug: Peg-IFNα2a
Sponsor:   Debiopharm International SA
Completed - verified April 2016

Evaluation of Sickle Cell Liver Disease

Condition:   Sickle Cell Disease
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2016

Study to Assess the Safety, Tolerability and Pharmacokinetics (PK) of MK-8892 in Participants With Pulmonary Arterial Hypertension (PAH) (MK-8892-005)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: MK-8892;   Drug: Placebo for MK-8892
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified April 2016

11C-acetate/18Fluorodeoxyglucose-FDG PET/CT and Cardiac MRI in Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Interventions:   Drug: 11C-acetate;   Drug: [18F]Fluoro-2-deoxy-2-D-glucose;   Other: Cardiac MRI
Sponsors:   University of Pennsylvania;   Brigham and Women's Hospital;   University of Maryland;   Yale University;   Washington University School of Medicine;   The Cardiovascular Medical Research and Education Fund
Active, not recruiting - verified April 2016

Beraprost-314d Added-on to Tyvaso® (BEAT)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Beraprost Sodium 314d Modified Release Tablets;   Drug: Placebo
Sponsor:   Lung Biotechnology PBC
Recruiting - verified March 2016

Regorafenib in Frail and/or Unfit for Chemotherapy Patients With Metastatic Colorectal Cancer

Conditions:   Colorectal Neoplasms;   Metastatic Disease
Intervention:   Drug: Regorafenib
Sponsors:   Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD);   Bayer
Active, not recruiting - verified April 2016

Flow MRI in Normal Pressure Hydrocephalus

Condition:   Normal Pressure Hydrocephalus
Intervention:   Other: Flow imaging
Sponsor:   Centre Hospitalier Universitaire, Amiens
Recruiting - verified April 2016

Targeting the Right Ventricle in Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Interventions:   Drug: Ranolazine;   Drug: Placebo
Sponsors:   University of Pennsylvania;   The Cardiovascular Medical Research and Education Fund;   Brigham and Women's Hospital;   University of Maryland;   Yale University;   Washington University School of Medicine
Active, not recruiting - verified April 2016

Resveratrol and Cardiovascular Health in the Elderly

Conditions:   Vascular Resistance;   Aging;   Hypertension;   Antioxidants;   Aerobic Capacity
Interventions:   Dietary Supplement: Resveratrol;   Drug: Placebo
Sponsor:   National Institute on Aging (NIA)
Recruiting - verified December 2015

A Study in Maintenance Kidney Transplant Recipients Following Conversion to Nulojix® (Belatacept)-Based

Condition:   Kidney Transplantation
Interventions:   Drug: Belatacept;   Drug: Tacrolimus;   Drug: Cyclosporine
Sponsor:   Bristol-Myers Squibb
Recruiting - verified March 2016

Study of Microcirculatory Effects of Bevacizumab in Patients Treated for Metastatic Colon Cancer or Glioblastoma

Conditions:   Metastatic Colorectal Cancer;   Glioblastoma;   Bevacizumab;   Capillaroscopy
Interventions:   Other: capillaroscopy;   Other: blood pressure measurement
Sponsor:   Centre Georges Francois Leclerc
Active, not recruiting - verified April 2016

Retinal Vessel Measurements as Clinically Useful Predictors in Veterans

Condition:   Diabetes
Intervention:  
Sponsor:   VA Office of Research and Development
Active, not recruiting - verified April 2016

Non-contrast Enhanced Cardiac Magnetic Resonance Imaging in the Diagnosis and Classification of Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Elevated Mean Pulmonary Arterial Pressure;   Normal Mean Pulmonary Arterial Pressure
Intervention:   Other: Cardiac MRI
Sponsor:   Medical University of Graz
Enrolling by invitation - verified April 2016

The Diagnosis and Treatment of Resistant Hypertension, the Prevalence and the Prognosis

Condition:   Hypertension, Resistant to Conventional Therapy
Intervention:  
Sponsors:   Chinese Academy of Medical Sciences, Fuwai Hospital;   Huazhong University of Science and Technology;   Shanghai Jiao Tong University School of Medicine
Active, not recruiting - verified April 2016

Use of Intravitreal Aflibercept Injection for Neovascular Glaucoma

Condition:   Neovascular Glaucoma
Intervention:   Drug: Aflibercept
Sponsor:   University of Colorado, Denver
Active, not recruiting - verified April 2016

Phase 3 Study of Bezafibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis

Condition:   PBC
Interventions:   Drug: Bezafibrate;   Drug: placebo
Sponsor:   Assistance Publique - Hôpitaux de Paris
Active, not recruiting - verified April 2016

Safety And Efficacy Of Sildenafil In Children With Pulmonary Arterial Hypertension

Conditions:   Pulmonary Arterial Hypertension;   Hypertension, Pulmonary
Intervention:   Drug: Sildenafil
Sponsor:   Pfizer
Recruiting - verified April 2016

WEUKBRE5716: Steroid-related Damage in Systemic Lupus Erythematosus (Hopkins)

Condition:   Systemic Lupus Erythematosus
Intervention:   Drug: Cumulative corticosteroid exposure
Sponsor:   GlaxoSmithKline
Completed - verified April 2016

Multicenter Study of Iloprost Inhaled in Pulmonary Hypertension After Repair of Congenital Heart Diseases (CHD)

Condition:   Pulmonary Hypertension
Interventions:   Drug: iloprost nebuliser solution;   Drug: distilled water
Sponsors:   Shanghai Jiao Tong University School of Medicine;   Cardiothoracic Surgical Group of Chinese Society of Pediatric Surgery
Recruiting - verified January 2016

An Open-Label, Long-Term Study of Oral Treprostinil in Subjects With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: UT-15C (treprostinil diethanolamine)
Sponsor:   United Therapeutics
Recruiting - verified April 2016

Trial of the Early Combination of Oral Treprostinil With Background Oral Monotherapy in Subjects With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: UT-15C (treprostinil diethanolamine);   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting - verified April 2016

Age-Related Changes in Body Composition

Conditions:   Hypertension;   Atherosclerosis
Intervention:  
Sponsor:   National Institute on Aging (NIA)
Completed - verified November 2015

Efficacy and Safety Study of Udenafil in Patient With Pulmonary Arterial Hypertension(PAH)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: udenafil;   Drug: placebo
Sponsor:   Dong-A ST Co., Ltd.
Completed - verified April 2016

Drug Use Investigation for VOLIBRIS® (Ambrisentan) (Pulmonary Arterial Hypertension)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Ambrisentan
Sponsor:   GlaxoSmithKline
Active, not recruiting - verified April 2016

Inhaled Iloprost in the Treatment of Patients With Pulmonary Hypertension up to 4 Years

Condition:   Pulmonary Hypertension
Intervention:   Drug: Ventavis inhaled (Iloprost, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified April 2016

Direct Application of Selective Laser Trabeculoplasty Using the "DIO-DENT 10" in Open Angle Glaucoma

Condition:   Glaucoma
Interventions:   Device: Direct application of Selective Laser Trabeculoplasty;   Device: Direct application of SLT in Open Angle Glaucoma
Sponsor:   Sheba Medical Center
Recruiting - verified April 2016

Safety and Tolerability of Valsartan in Children 6 to 17 Years of Age

Conditions:   Hypertension;   Chronic Kidney Disease
Interventions:   Drug: Valsartan;   Drug: amlodipine;   Drug: Hydrochlorothiazide
Sponsor:   Novartis Pharmaceuticals
Completed - verified April 2016

Diabetes Prevention Strategies in Women With Gestational Diabetes Mellitus (GDM)

Conditions:   Gestational Diabetes;   Obesity
Intervention:   Behavioral: Lifestyle Counseling
Sponsors:   Kaiser Permanente;   Agency for Healthcare Research and Quality (AHRQ)
Completed - verified April 2016

SOLX Gold Shunt for Refractory Glaucoma

Conditions:   Glaucoma;   Glaucoma, Open Angle
Intervention:   Device: SOLX Gold Shunt
Sponsor:   SOLX, Inc.
Completed - verified December 2015

Relaxation Response Training to Treat Hypertension

Condition:   Hypertension
Interventions:   Behavioral: Relaxation Response;   Behavioral: Relaxation Response
Sponsors:   Massachusetts General Hospital;   Brigham and Women's Hospital
Completed - verified April 2016

A Phase 2a Study To Evaluate The Pharmacokinetics, Safety, Efficacy, Tolerability, And Pharmacodynamics of Sotatercept (ACE-011) for the Correction of Anemia in Subjects With End-stage Renal Disease on Hemodialysis.

Condition:   Anemia
Interventions:   Biological: Sotatercept;   Biological: Placebo
Sponsors:   Celgene Corporation;   Acceleron Pharma, Inc.
Completed - verified April 2016

Cyclooxygenase-2 Inhibitor for Adjuvant Anticancer Effect in Patients With Biliary-pancreas Cancer

Conditions:   Bile Duct Cancer;   Pancreatic Cancer
Intervention:   Drug: Cox2 inhibitor (Celecoxib)
Sponsors:   Seoul National University Hospital;   Seoul National University Bundang Hospital
Recruiting - verified April 2016

Everolimus and Vatalanib in Treating Patients With Advanced Solid Tumors

Conditions:   Gastrinoma;   Glucagonoma;   Insulinoma;   Metastatic Gastrointestinal Carcinoid Tumor;   Metastatic Pheochromocytoma;   Pancreatic Polypeptide Tumor;   Recurrent Gastrointestinal Carcinoid Tumor;   Recurrent Islet Cell Carcinoma;   Recurrent Melanoma;   Recurrent Neuroendocrine Carcinoma of the Skin;   Recurrent Non-small Cell Lung Cancer;   Recurrent Pheochromocytoma;   Recurrent Renal Cell Cancer;   Somatostatinoma;   Stage III Neuroendocrine Carcinoma of the Skin;   Stage IV Melanoma;   Stage IV Non-small Cell Lung Cancer;   Stage IV Renal Cell Cancer;   Thyroid Gland Medullary Carcinoma;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions:   Drug: everolimus;   Drug: vatalanib;   Other: pharmacological study;   Other: laboratory biomarker analysis;   Procedure: dynamic contrast-enhanced magnetic resonance imaging;   Procedure: ultrasound imaging
Sponsors:   Mayo Clinic;   National Cancer Institute (NCI)
Active, not recruiting - verified March 2016

Prospective Randomized Trial of Laparoscopic Versus Open Liver Resection for HCC

Condition:   Hepatocellular Carcinoma
Intervention:   Procedure: Liver resection
Sponsor:   Seoul National University Hospital
Recruiting - verified April 2016

Long Term Treatment of End Stage Renal Disease Patients With Lanthanum Carbonate (Fosrenol)

Condition:   Hyperphosphatemia
Intervention:  
Sponsor:   Shire
Active, not recruiting - verified April 2016

Examining the Link Between Trace Elements and Cardiovascular Disease Risk Factors in Young Adults

Conditions:   Cardiovascular Diseases;   Metabolic Syndrome X;   Hypertension;   Inflammation;   Atherosclerosis
Intervention:  
Sponsors:   University of North Carolina, Chapel Hill;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified December 2011

The Autonomic Nervous System and Obesity

Conditions:   OBESITY;   HYPERTENSION;   PURE AUTONOMIC FAILURE;   SHY-DRAGER SYNDROME
Interventions:   Drug: Trimethaphan;   Drug: Trimethaphan;   Drug: Pseudoephedrine
Sponsor:   Vanderbilt University
Active, not recruiting - verified April 2016

Treatment of Orthostatic Hypotension in Autonomic Failure

Conditions:   Autonomic Failure;   Orthostatic Hypotension
Interventions:   Drug: Atomoxetine;   Drug: Acarbose;   Drug: Pyridostigmine Bromide;   Drug: Yohimbine;   Drug: Midodrine HCl;   Drug: placebo;   Drug: Modafinil;   Drug: Octreotide;   Other: water intake;   Drug: Diphenhydramine Hydrochloride;   Drug: Ranitidine HCL;   Drug: Tranylcypromine;   Drug: Ergotamine/ Caffeine;   Drug: Celecoxib;   Drug: Pseudoephedrine;   Drug: Methylphenidate;   Drug: Indomethacin;   Drug: Ibuprofen;   Drug: Oxymetazoline 0.05% nasal solution;   Dietary Supplement: Bovril;   Drug: Acetazolamide;   Drug: Rivastigmine tartrate;   Drug: Carbidopa/levodopa;   Device: Inflatable abdominal binder;   Device: inflatable abdominal binder (sham)
Sponsor:   Vanderbilt University
Recruiting - verified April 2016

Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia

Conditions:   Pulmonary Hypertension;   Sickle Cell Anemia;   Sickle Cell Disease
Intervention:  
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified August 2015

Jackson Heart Study (JHS) of Cardiovascular Diseases in African Americans

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Atherosclerosis;   Coronary Disease;   Hypertension;   Cerebrovascular Disorders
Intervention:  
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   National Institute on Minority Health and Health Disparities (NIMHD)
Active, not recruiting - verified April 2016