High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Renal Denervation on Quality of 24-hr BP Control by Ultrasound In Resistant Hypertension

Conditions:   Hypertension;   Vascular Diseases
Interventions:   Device: PRDS-001 Renal Denervation Ultrasound System;   Procedure: Sham Procedure
Sponsor:   JIMRO Co., Ltd.
Recruiting - verified September 2016

A Study to Evaluate Efficacy and Safety of HCP1401 for Stage 2 Hypertension Patients Not Controlled by HCP0605

Condition:   Hypertension
Interventions:   Drug: HCP1401;   Drug: HCP0605
Sponsor:   Hanmi Pharmaceutical Company Limited
Completed - verified September 2016

Salt-sensitive Hypertension Study in Lantian County

Condition:   Hypertension
Intervention:   Dietary Supplement: salt
Sponsor:   First Affiliated Hospital Xi'an Jiaotong University
Not yet recruiting - verified September 2016

Effects of Nitrate in Vegetables on Blood Pressure in Subjects With Prehypertension

Conditions:   Hypertension;   Cardiovascular Disease
Interventions:   Other: High nitrate vegetables;   Dietary Supplement: Low nitrate vegetables + nitrate;   Other: Low nitrate vegetables
Sponsors:   Karolinska Institutet;   Karolinska University Hospital
Recruiting - verified September 2016

Estrogen Receptor Antagonist in Patients With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Fulvestrant
Sponsor:   University of Pennsylvania
Not yet recruiting - verified September 2016

Study Evaluating OTX-TP in OAG and OH

Conditions:   Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Travoprost;   Other: Placebo Vehicle
Sponsor:   Ocular Therapeutix, Inc.
Not yet recruiting - verified September 2016

Actigraphy in Pediatric Pulmonary Hypertension

Condition:   Pediatric Pulmonary Hypertension
Intervention:   Other: No interventions / observations only
Sponsor:   University of Colorado, Denver
Not yet recruiting - verified September 2016

Fimasartan and Rosuvastatin for Hypertension and Dyslipidemia Control

Conditions:   Cardiovascular Diseases;   Hyperlipidemias
Intervention:  
Sponsor:   Boryung Pharmaceutical Co., Ltd
Not yet recruiting - verified September 2016

A Phase 2 Trial of IW-1973, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Stable Type 2 Diabetes and Hypertension

Conditions:   Diabetes Mellitus, Type 2;   Hypertension
Interventions:   Drug: Matching Placebo;   Drug: IW-1973
Sponsor:   Ironwood Pharmaceuticals, Inc.
Recruiting - verified September 2016

Spironolactone on Fibrosis Progrssion-Portal Hypertension(FP-PH)in Cirrhosis

Conditions:   Cirrhosis;   Portal Hypertension
Interventions:   Drug: Spironolactone;   Drug: Carvedilol
Sponsors:   Changqing Yang;   Nanfang Hospital of Southern Medical University;   Fudan University
Not yet recruiting - verified September 2016

TARGET BP I Clinical Trial

Condition:   Hypertension
Interventions:   Drug: Dehydrated alcohol;   Device: Peregrine System Kit (Sham Procedure)
Sponsor:   Ablative Solutions, Inc.
Not yet recruiting - verified September 2016

Changes in Central Arterial Pressure When Comparing Nifedipine/Labetalol for Routine Hypertension Control in Pregnancy

Condition:   Hypertension
Interventions:   Other: Nifedipine;   Other: Labetalol
Sponsor:   St. Louis University
Enrolling by invitation - verified September 2016

Renal Denervation by Iberis MultiElectrode Renal Denervation System in Patients With Primary Hypertension

Condition:   Primary Hypertension
Interventions:   Device: Renal Denervation System (AngioCare);   Procedure: Sham procedure
Sponsor:   Shanghai AngioCare Medical
Not yet recruiting - verified September 2016

CS-03 Pressure-Volume Loop Sub-study With RV Lead Positioning

Condition:   Hypertension
Intervention:   Device: BackBeat-PHC
Sponsor:   BackBeat Medical Inc
Recruiting - verified September 2016

Nutrition, Oral Health and Type 2 Diabetes

Condition:   Inflammation
Intervention:   Dietary Supplement: Diet
Sponsor:   Kristianstad University
Recruiting - verified September 2016

Comprehensive Treatment of Angina in Women With Microvascular Dysfunction

Conditions:   Angina Pectoris;   Coronary Microvascular Disease
Interventions:   Dietary Supplement: Diet;   Behavioral: Training;   Drug: Medication (with statin and ACE-inhibition)
Sponsors:   Bispebjerg Hospital;   University Hospital Bispebjerg and Frederiksberg;   Cambridge Weight Plan Limited
Not yet recruiting - verified September 2016

NSAID Use in Postpartum Hypertensive Women

Condition:   Hypertension
Interventions:   Drug: Acetaminophen;   Drug: NSAID
Sponsor:   St. Louis University
Enrolling by invitation - verified September 2016

Risk Reduction for Alzheimer's Disease

Conditions:   Cognitively Normal Older Adults;   Hypertension;   Subjective Cognitive Decline;   Family History of Alzheimer's Disease
Interventions:   Drug: Angiotensin II receptor blocker (ARB, losartan) and calcium channel blocker (CCB, amlodipine);   Behavioral: Aerobic Exercise Training;   Other: Usual Care;   Behavioral: Stretching Exercise;   Drug: Atorvastatin
Sponsors:   University of Texas Southwestern Medical Center;   Texas Health Resources;   University of Kansas Medical Center;   Washington University School of Medicine;   Pennington Biomedical Research Center;   Michigan State University
Recruiting - verified September 2016

Bicarbonate Administration in CKD

Conditions:   Chronic Kidney Disease;   Metabolic Acidosis
Interventions:   Drug: Sodium bicarbonate;   Drug: Placebo
Sponsor:   University of Colorado, Denver
Not yet recruiting - verified September 2016

Noninvasive Perioperative Monitoring of Arterial Stiffness, Volume and Nutritional Status in Stable Renal Transplant Recipients

Conditions:   Arterial Calcification;   Aortic Stiffness;   High Blood Pressure;   Kidney Transplantation
Interventions:   Device: BR-102 plus PWA;   Device: Tanita MC780 MA S
Sponsor:   Medical University of Warsaw
Recruiting - verified September 2016

Mobile Health Technology for Chronic Kidney Disease Patients: Medication Management

Conditions:   Renal Insufficiency, Chronic;   Hypertension;   Medication Reconciliation;   Mobile Applications
Interventions:   Other: Usual Care;   Device: Integrated mobile medication app;   Device: Commercially available mobile medication app
Sponsors:   University Health Network, Toronto;   Canadian Institutes of Health Research (CIHR)
Recruiting - verified September 2016

Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features

Conditions:   Pre-Eclampsia;   HELLP Syndrome;   Eclampsia
Interventions:   Drug: Acetaminophen;   Drug: Ibuprofen
Sponsor:   University of New Mexico
Not yet recruiting - verified September 2016

Triamcinolone Injections for Persistent Choroidal Effusions Post Glaucoma Surgery

Conditions:   Glaucoma;   Choroidal Effusions
Interventions:   Drug: Triamcinolone Acetonide 1 ml of 40 mg/mL suspension;   Drug: Prednisolone acetate 1%
Sponsor:   Sunnybrook Health Sciences Centre
Recruiting - verified September 2016

Intravitreal Ranibizumab (Lucentis®) for Neovascular Glaucoma- a Randomized Controlled Study

Conditions:   Glaucoma, Neovascular;   Ranibizumab
Intervention:   Drug: Intravitreal ranibizumab
Sponsors:   LEANDRO CABRAL ZACHARIAS;   Novartis
Not yet recruiting - verified September 2016

Contrast Enhanced Ultrasound Imaging for Cerebral Perfusion Measurement in Cerebral Vasospasm After SAH

Condition:   Subarachnoid Hemorrhage
Intervention:  
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified September 2016

Evaluation of the Repeatability and Reproducibility of AngioVue

Condition:   Normal, Glaucoma & Retinal Pathology
Intervention:   Device: Optical Coherence Tomography Angiography
Sponsor:   Optovue
Enrolling by invitation - verified September 2016

Study of CS-3150 in Patients With Essential Hypertension

Condition:   Essential Hypertension
Interventions:   Drug: CS-3150;   Drug: Eplerenone
Sponsor:   Daiichi Sankyo Co., Ltd.
Recruiting - verified September 2016

Safety and Efficacy of Three Variants of Canaloplasty With Phacoemulsification to Treat Glaucoma and Cataract

Condition:   Primary Open Angle Glaucoma, Cataract
Intervention:   Procedure: canaloplasty and phacoemulsification
Sponsor:   Military Institute of Medicine, Poland
Recruiting - verified September 2016

De Novo Everolimus Versus Tacrolimus in Combination With Mofetil Mycophenolate and Low Dose Corticosteroids to Reduce Tacrolimus Induced Nephrotoxicity in Liver Transplantation: a Prospective, Multicentric, Randomised Study

Condition:   Liver Transplantation
Interventions:   Drug: Tacrolimus;   Drug: Everolimus;   Drug: Mycophenolate mofetil;   Drug: Prednisolone, Prednisone or Methylprednisolone
Sponsor:   Rennes University Hospital
Not yet recruiting - verified September 2016

The Effect of Intervention With Potassium and/ or Magnesium-enriched Salt on Neurological Performance of Stroke Patients

Condition:   Stroke
Interventions:   Other: Regular salt;   Other: Potassium-enriched salt;   Other: Potassium and magnesium-enriched salt
Sponsor:   Academia Sinica, Taiwan
Completed - verified September 2016

Trial to Reduce Sitting Time in Postmenopausal Latina Women at Increased Risk for Heart Disease

Condition:   Sedentary Lifestyle
Interventions:   Device: ActivPAL inclinometer;   Behavioral: Phone counseling call: Breaking up sitting time;   Behavioral: In-person counseling: Breaking up sitting time;   Behavioral: Phone counseling call: Healthy living;   Other: Tools to prompt standing;   Behavioral: In-person counseling: Healthy living
Sponsors:   University of California, San Diego;   South Bay Latino Research Center;   San Ysidro Health Center;   San Diego State University
Not yet recruiting - verified September 2016

Health Outcomes of Patients With Type 2 Diabetes Treated With Dapagliflozin in Conjunction With Insulin

Condition:   Type 2 Diabetes Mellitus
Intervention:  
Sponsors:   Lawson Health Research Institute;   AstraZeneca
Not yet recruiting - verified September 2016

Nutrition and Exercise Study to Understand Metabolic Syndrome

Conditions:   Metabolic Syndrome;   Obesity;   Insulin Resistance
Interventions:   Behavioral: Health education;   Behavioral: Yoga
Sponsor:   Vanderbilt University
Completed - verified September 2016

Home-base Kidney Care in Zuni Indians

Condition:   Chronic Kidney Disease
Intervention:   Other: Educational and lifestyle coaching
Sponsors:   University of New Mexico;   Zuni Tribal Administration;   Zuni comprehensive Community Health Center, Indian Health Services
Completed - verified September 2016

Outcomes of Prophylaxis and On-demand Treatment for Severe Hemophiliacs and Collection of Baseline Data in Hemophiliacs in Taiwan

Condition:   Hemophilia
Intervention:   Other: collection of baseline data
Sponsors:   Taiwan Society of Thrombosis and Hemostasis;   Changhua Christian Hospital;   Taipei Medical University Hospital;   Taipei Veterans General Hospital, Taiwan;   Taipei Medical University Shuang Ho Hospital;   Taichung Veterans General Hospital;   China Medical University Hospital;   Kaohsiung Medical University Chung-Ho Memorial Hospital
Enrolling by invitation - verified September 2016

MOMENTUM 3 Continued Access Protocol

Condition:   Advanced Refractory Left Ventricular Heart Failure
Intervention:   Device: HeartMate 3 LVAS
Sponsors:   St. Jude Medical;   Thoratec, LLC
Recruiting - verified September 2016

Ambulatory Blood Pressure and the Normal Increase in Maternal Blood Pressure Postpartum

Condition:   Normotensive Postpartum Cesarean Section Patients
Intervention:  
Sponsor:   St. Louis University
Enrolling by invitation - verified September 2016

Evolution and Clinical Outcomes in Patients Undergoing Liver Transplantation

Conditions:   Liver Disease;   Nutrition Disorders
Intervention:  
Sponsor:   Federal University of Minas Gerais
Recruiting - verified September 2016

Study of NT-501 Encapsulated Cell Therapy for Glaucoma Neuroprotection and Vision Restoration

Condition:   Glaucoma
Interventions:   Drug: NT-501 ECT implant;   Other: Sham
Sponsor:   Stanford University
Recruiting - verified September 2016

Examination of Ventavis (Iloprost) Inhalation Behavior Using the I-Neb AAD System in Patients With Pulmonary Arterial Hypertension When Switching the Iloprost Nebulizer Solution for Inhalation From 10 μg/mL (V10) to 20 μg/mL (V20)

Condition:   Hypertension, Pulmonary
Interventions:   Drug: Iloprost,(Ventavis, BAYQ6256);   Device: I-Neb AAD system
Sponsor:   Bayer
Recruiting - verified September 2016

P.A.R.Q.V.E III - Comparison of the Educational Program With and Without Multidisciplinary Care

Conditions:   Osteoarthritis;   Metabolic Diseases
Interventions:   Behavioral: Womac;   Behavioral: Lequesne;   Behavioral: VAS;   Behavioral: IPAQ;   Behavioral: FTSST;   Behavioral: TUG;   Behavioral: Six-minute Test;   Behavioral: Two days of lectures;   Behavioral: Session with the psychologists;   Behavioral: Sessions with the physical therapy team;   Behavioral: Sessions with the physical educators team;   Behavioral: Nutritional habits to be improved
Sponsor:   University of Sao Paulo General Hospital
Not yet recruiting - verified September 2016

Portal Hypertension and Systemic Endothelial Function

Conditions:   Cystic Fibrosis;   Portal Hypertension
Intervention:   Other: measure of endothelial function
Sponsor:   Hopital Foch
Recruiting - verified September 2016

Non-interventional, Postauthorization Safety Study of Ventavis for Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Ventavis (Iloprost, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified September 2016

The EASE Study - Human Factor and Usability Testing of a Binocular OCT System

Conditions:   Glaucoma;   Retinal Disease;   Strabismus;   Healthy Volunteers
Intervention:   Device: Binocular OCT prototype
Sponsor:   University College, London
Recruiting - verified June 2016

A Phase 3 Long-term Study of TAK-536 in Pediatric Patients 6 to Less Than 16 Years With Hypertension

Condition:   Pediatric Hypertension
Interventions:   Drug: TAK-536 2.5 mg;   Drug: TAK-536 5 mg
Sponsor:   Takeda
Recruiting - verified September 2016

Evaluation of the Efficacy of Citrulline Supplementation on the Delay of Delivery for Women Hospitalized for Pre-eclampsia (CITRUPE)

Conditions:   Pre-eclampsia;   Pregnancy
Interventions:   Drug: Citrulline;   Drug: Placebo
Sponsor:   Nantes University Hospital
Not yet recruiting - verified September 2016

A Physical Activity Program in End-state Liver Disease

Conditions:   End-stage Liver Disease (ESLD);   Liver Transplant;   Sarcopenia;   Poor Physical Fitness;   Cirrhosis;   Portal Hypertension
Interventions:   Other: Nutritional consultation;   Behavioral: Physical training program;   Behavioral: Behavioral modification therapy
Sponsor:   University of Arkansas
Enrolling by invitation - verified September 2016

Open-label, Single Arm Trial of BI 695502 in Patients With Previously Untreated Metastatic Colorectal Cancer

Condition:   Colorectal Neoplasms
Interventions:   Drug: BI 695502;   Drug: chemotherapy
Sponsor:   Boehringer Ingelheim
Recruiting - verified September 2016

A Long-term Extension Study of Riociguat in Patients With Symptomatic Pulmonary Arterial Hypertension.

Condition:   Hypertension, Pulmonary-
Intervention:   Drug: Adempas (Riociguat, BAY63-2521)
Sponsor:   Bayer
Recruiting - verified September 2016

Inhibition of Urinary Angiotensinogen and the Reduction of Blood Pressure by SGLT2 Inhibition in Patients With Type 2 Diabetes

Conditions:   Type 2 Diabetes;   Hypertension
Interventions:   Drug: Dapagliflozin;   Drug: Sulfonylurea;   Drug: Placebo
Sponsors:   Tulane University;   AstraZeneca
Recruiting - verified September 2016

Cardiovascular Outcomes of Low Testosterone

Condition:   Hypogonadism
Interventions:   Drug: Acyline;   Drug: Placebo Gel;   Drug: Placebo Tablet;   Drug: Testosterone Gel;   Drug: Arimidex
Sponsor:   University of Colorado, Denver
Recruiting - verified September 2016

Long-term Study of CS-3150 as Monotherapy or in Combination With Other Antihypertensive Drug in Japanese Patients With Essential Hypertension

Condition:   Essential Hypertension.
Intervention:   Drug: CS-3150
Sponsor:   Daiichi Sankyo Co., Ltd.
Recruiting - verified September 2016

Taxi METERS: Measuring Effectiveness of Technology, Education, Referrals and Support

Condition:   Improving Blood Pressure Control
Interventions:   Other: CONTROL- Usual & Customary Health Fair Follow-up;   Other: Health Fair + TECH [Text Messaging + Home Blood Pressure Monitoring];   Other: Heal th Fair + TECH [Text Messaging + Home Blood Pressure Monitoring] + Social Network Support (SNS)
Sponsor:   Memorial Sloan Kettering Cancer Center
Enrolling by invitation - verified September 2016

Healthy Families: Transforming Care for Obese Children at NYU Lutheran Family Health Centers

Condition:   Childhood Obesity
Interventions:   Behavioral: Social Support;   Behavioral: Nutrition Session;   Behavioral: Physical Activity Session
Sponsor:   New York University School of Medicine
Completed - verified September 2016

Adding MgSO4 to Epidural Levobupivacaine in CS for Patients With Preeclampsia

Condition:   Preeclampsia
Interventions:   Drug: Levobupivacaine hydrochloride;   Drug: Magnesium sulphate;   Drug: Saline 0.9%
Sponsor:   Mohamed Sayed Abdelhafez
Recruiting - verified September 2016

Sleep-related Breathing Disorders in Cardiological Outpatients

Condition:   Sleep Apnea Syndromes
Intervention:  
Sponsors:   Wissenschaftliches Institut Bethanien e.V;   University Clinic Cologne
Active, not recruiting - verified September 2016

PADN to Treat Severe Obstructive Sleep Apnea

Condition:   Obstructive Sleep Apnea Syndrome
Interventions:   Procedure: Pulmonary Arterial Denervation;   Procedure: Sham procedure
Sponsor:   The First Affiliated Hospital with Nanjing Medical University
Recruiting - verified September 2016

A Study of Ubenimex in Patients With Pulmonary Arterial Hypertension (WHO Group 1)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: ubenimex;   Other: placebo
Sponsor:   Eiger BioPharmaceuticals
Recruiting - verified September 2016

Indian Ragas on Health - a Electrophysiological Study

Condition:   Hypertension
Intervention:   Other: Music Intervention
Sponsors:   MS Ramaiah Medical College & Hospitals;   Rajiv Gandhi University of Health Sciences
Recruiting - verified September 2016

Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension - CATALYST

Condition:   Connective Tissue Disease-Associated Pulmonary Arterial Hypertension
Interventions:   Drug: Placebo capsules;   Drug: Bardoxolone methyl capsules
Sponsor:   Reata Pharmaceuticals, Inc.
Recruiting - verified September 2016

New International CTEPH Database

Conditions:   Chronic Thromboembolic Pulmonary Hypertension;   CTEPH
Intervention:  
Sponsor:   International CTEPH Association
Active, not recruiting - verified September 2016

Point of Care UltraSound by Surgeons

Conditions:   Biliary Calculi;   Cholecystitis, Acute;   Cholecystitis, Chronic;   Cholelithiasis;   Calculus of Bile Duct With Cholangitis;   Acute Diverticulitis;   Diverticulosis;   Colitis;   Perforation of Colon;   Abscess
Interventions:   Device: Bedside performed Ultrasound Scan by the surgeon;   Other: Radiology report;   Procedure: Intra-operative findings
Sponsors:   Connolly Hospital Blanchardstown;   Royal College of Surgeons, Ireland;   Modular UltraSound ESTES Course (MUSEC);   European Society for Trauma and Emergency Surgery (ESTES)
Recruiting - verified September 2016

A Study of the ReCor Medical Paradise System in Clinical Hypertension

Conditions:   Hypertension;   Vascular Diseases
Interventions:   Device: The Paradise® Renal Denervation Ultrasound System;   Device: Sham Procedure
Sponsor:   ReCor Medical, Inc.
Recruiting - verified July 2016

"First-in-human" Study To Assess the Safety and Tolerability of PBF-677 in Healthy Volunteers

Condition:   Glaucoma
Interventions:   Drug: PBF-677;   Drug: Placebo
Sponsor:   Palobiofarma SL
Completed - verified September 2016

Effects of Sildenafil on Penile Vascular Function in Hypertensive Men With Erectile Dysfunction

Conditions:   Arterial Hypertension;   Erectile Dysfunction
Interventions:   Drug: sildenafil citrate;   Other: comparator group
Sponsor:   National Institute of Cardiology, Laranjeiras, Brazil
Recruiting - verified September 2016

Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer

Conditions:   Breast Carcinoma;   Hypertension
Intervention:   Other: Laboratory Biomarker Analysis
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified September 2016

Clinical Study to Explore the Effects of Actelion's Latest Endothelin Receptor Antagonist (ERA) - at Different Dose Strengths - on the Efficacy, Safety and Tolerability in Subjects With Essential Hypertension

Condition:   Essential Hypertension
Interventions:   Drug: ERA;   Drug: Lisinopril;   Other: Placebo
Sponsor:   Actelion
Recruiting - verified September 2016

The Relationship Between HHcy and Contrast-induced Nephropathy in Hypertensive Patients After Coronary Artery Diagnosis and Treatment

Conditions:   Homocysteine;   Coronary Disease;   Angioplasty,Balloon,Coronary;   Contrast Media;   Nephropathy;   Hypertension
Interventions:   Drug: Enalapril Maleate Tablets(as the program-based antihypertension);   Drug: Enalapril Maleate and Folic Acid tablets(as the program-based antihypertension);   Drug: Placebo
Sponsor:   Fuling Central Hospital of Chongqing City
Recruiting - verified September 2016

Spirulina Supplementation and Cardiovascular Risk in Obese Caucasians With Treated Hypertension

Condition:   Obesity
Interventions:   Dietary Supplement: Spirulina;   Other: Placebo
Sponsor:   Poznan University of Medical Sciences
Active, not recruiting - verified September 2016

The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Macitentan;   Drug: Tadalafil;   Drug: Selexipag
Sponsor:   Actelion
Recruiting - verified September 2016

A Study to Understand the Treatment Patterns in Patients With Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension During a Switch of Treatment to Adempas in Real-life Clinical Practice

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsor:   Bayer
Completed - verified September 2016

Clinical Study to Assess the Efficacy and Safety of Macitentan in Patients With Pulmonary Hypertension After Left Ventricular Assist Device Implantation

Condition:   Pulmonary Hypertension
Interventions:   Drug: Macitentan 10mg;   Drug: Placebo sugar pill
Sponsor:   Actelion
Recruiting - verified September 2016

Atorvastatin Effectiveness and Safety in Cardiology Patients in Real World Setting

Condition:   Coronary Artery Disease, Hypercholesterolemia, Hypertension
Intervention:   Other: No intervention
Sponsor:   Pfizer
Not yet recruiting - verified September 2016

Egypt Hypertension Study

Condition:   Different Classes of the Antihypertensive Treatment.
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified September 2016

Safety and Efficacy Study of LHW090 in Resistant Hypertension Patients

Condition:   Patients, Resistant Hypertension
Interventions:   Drug: LHW090;   Drug: Placebo
Sponsor:   Novartis Pharmaceuticals
Recruiting - verified September 2016

A Phase 3b Study of Erythropoietin Drugs Using a Specified Dosing Algorithm in Patients With Chronic Kidney Disease on Hemodialysis

Condition:   Chronic Kidney Disease (CKD)
Interventions:   Drug: Epoetin Hospira Arm;   Other: Standard of Care Arm;   Drug: IV Iron
Sponsors:   Pfizer;   Hospira, Inc.
Completed - verified September 2016

We Talk About Our Hypertension

Condition:   Hypertension
Intervention:   Behavioral: Storytelling
Sponsors:   Institute of Population, Health and Development, Vietnam;   University of Massachusetts, Worcester
Active, not recruiting - verified September 2016

Preoperative Nutritional Support in Malnutritional Cancer Patients

Conditions:   Pancreatic Cancer;   Biliary Cancer;   Malnutrition
Intervention:   Dietary Supplement: nutritional support program
Sponsors:   National Cancer Center, Korea;   Fresenius Kabi
Recruiting - verified September 2016

Prenatal Inflammation and Perinatal Outcomes

Condition:   Pregnancy
Intervention:   Biological: inactivated seasonal flu vaccine
Sponsors:   University of Calgary;   Northwestern University
Recruiting - verified September 2016

Analysis of CRBSI Rates in Patients With a NexSite™ HD (Hemodialysis) Catheter

Condition:   End Stage Renal Disease
Intervention:   Device: NexSite HD Patients
Sponsor:   Marvao Medical
Recruiting - verified September 2016

SPYRAL HTN-ON MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Recruiting - verified September 2016

SPYRAL HTN-OFF MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Recruiting - verified September 2016

Natural History of Noncirrhotic Portal Hypertension

Conditions:   Cystic Fibrosis;   Immunologic Deficiency Syndrome;   Turner Syndrome;   Congenital Hepatic Fibrosis;   Idiopathic Non-Cirrhotic Portal Hypertension
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified September 2016

Whole-exome Sequencing in Childhood Obesity

Condition:   Childhood Obesity
Intervention:  
Sponsors:   National University, Singapore;   Health Promotion Board, Singapore;   Genome Institute of Singapore A*Star, Singapore
Recruiting - verified September 2016

Effect of Reminders on Adherence

Conditions:   Diabetes;   Hypertension
Interventions:   Behavioral: Prediction mailing;   Behavioral: Commitment mailing;   Behavioral: Reminder;   Behavioral: Anonymity;   Behavioral: Identification
Sponsor:   University of Pennsylvania
Completed - verified September 2016

A Study of Vonapanitase (PRT-201) Administered Immediately After Radiocephalic Arteriovenous Fistula(AVF) Creation in Patients With Chronic Kidney Disease (CKD) (PATENCY-2)

Condition:   Chronic Kidney Disease
Interventions:   Drug: vonapanitase;   Drug: Placebo
Sponsor:   Proteon Therapeutics
Recruiting - verified September 2016

Activity and Risk Profile of Ponatinib in Chronic Phase Patients With Chronic Myeloid Leukemia Resistant to Imatinib

Conditions:   Chronic Myeloid Leukemia;   Chronic Phase;   Adults
Intervention:   Drug: Ponatinib
Sponsor:   Gruppo Italiano Malattie EMatologiche dell'Adulto
Recruiting - verified September 2016

A Prospective, Observational, Post-Authorization Long-term Safety Surveillance on Antihypertensive Treatment With Kanarb® (Fimasartan)

Condition:   Liver Dysfunction
Intervention:  
Sponsor:   Boryung Pharmaceutical Co., Ltd
Active, not recruiting - verified September 2016

Stop Retinal Ganglion Cell Dysfunction Study

Condition:   Glaucoma
Interventions:   Drug: Latanoprost;   Drug: Bimatoprost;   Drug: Travoprost;   Drug: Timolol;   Drug: Dorzolamide;   Drug: Brinzolamide;   Drug: Acetazolamide;   Drug: Methazolamide
Sponsors:   University of Miami;   National Eye Institute (NEI)
Recruiting - verified September 2016

Comparative Effects of Moxonidine on Bone Metabolism, Vascular and Cellular Aging in Hypertensive Postmenopausal Women

Conditions:   Osteopenia;   Arterial Hypertension
Interventions:   Drug: Moxonidine;   Drug: Bisoprolol
Sponsor:   National Research Center for Preventive Medicine
Recruiting - verified September 2016

Weight Loss Referral for Healthier Survivorship in Obese Stage I-II Endometrial Cancer Survivors or Atypical Hyperplasia

Conditions:   Complex Endometrial Hyperplasia With Atypia;   Stage IA Uterine Corpus Cancer;   Stage IB Uterine Corpus Cancer;   Stage II Uterine Corpus Cancer
Interventions:   Behavioral: Weight Loss Specialist;   Other: Quality-of-Life Assessment;   Other: Medical Chart Review
Sponsors:   Case Comprehensive Cancer Center;   National Cancer Institute (NCI)
Active, not recruiting - verified September 2016

Natural History and Biology of Long-Term Late Effects Following Hematopoietic Cell Transplant for Childhood Hematologic Malignancies

Conditions:   Acute Lymphoblastic Leukemia/Lymphoma;   Myelodysplasia;   Acute Myelogenous Leukemia;   Juvenile Myelomonocytic Leukemia;   Chronic Myelogenous Leukemia
Intervention:  
Sponsors:   Center for International Blood and Marrow Transplant Research;   Pediatric Blood and Marrow Transplant Consortium;   National Marrow Donor Program
Recruiting - verified September 2016

Phase IIa Study of the Product QGC001 Compared With Placebo in Patients With Essential Hypertension

Condition:   Essential Hypertension
Interventions:   Drug: QGC001;   Drug: Placebo
Sponsor:   Quantum Genomics SA
Completed - verified September 2016

Determining the Risk Elevation After Maternity

Condition:   Preeclampsia
Intervention:   Other: Observational
Sponsors:   Ottawa Hospital Research Institute;   The Ottawa Hospital Academic Medical Association
Recruiting - verified September 2016

Effects of Ketamine in the Acute Phase of Suicidal Ideation

Condition:   Suicidal Ideation
Interventions:   Other: Baseline evaluation;   Drug: 1st perfusion of ketamine;   Drug: 1st perfusion of saline;   Other: Follow-up between perfusions;   Drug: 2nd perfusion of ketamine;   Drug: 2nd perfusion of saline;   Other: Follow-up after perfusions
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Recruiting - verified September 2016

The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial II

Condition:   Intracerebral Hemorrhage
Intervention:   Drug: labetalol/hydralazine/enalapril
Sponsor:   University of Alberta
Recruiting - verified September 2016

Non-invasive Assessment of Pulmonary Artery Pressure

Condition:   Pulmonary Hypertension
Intervention:  
Sponsors:   Medical University of Graz;   National Bank of Austria;   Ludwig Boltzmann Institute for Lung Vascular Research
Recruiting - verified September 2016

Risk Assessment by Cardiovascular Biomarkers in Chronic Dialysis Patients

Condition:   Endstage Renal Disease
Intervention:  
Sponsor:   University Hospital, Basel, Switzerland
Not yet recruiting - verified September 2016

Impact of the CommunityRx Program on Health, Service Utilization and Costs

Condition:   Connecting Patients to Self-care Resources
Intervention:   Behavioral: HealtheRx
Sponsor:   University of Chicago
Recruiting - verified September 2016

Blopress Tablets Specified Drug-use Survey "Hypertension: Survey on Patients With Metabolic Syndrome"

Condition:   Hypertension
Intervention:   Drug: candesartan cilexetil
Sponsor:   Takeda
Completed - verified September 2016

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease (CKD), Not on Dialysis

Condition:   Anemia
Interventions:   Drug: Roxadustat;   Drug: Placebo
Sponsors:   AstraZeneca;   FibroGen
Recruiting - verified September 2016

Endothelin Receptor Function and Acute Stress

Condition:   Hypertension
Interventions:   Drug: Bosentan;   Drug: Placebo
Sponsors:   Augusta University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified September 2016

EXPERT, EXPosurE Registry RiociguaT in Patients With Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat(BAY63-2521)
Sponsor:   Bayer
Recruiting - verified September 2016

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy;   Device: Carotid stenting
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2016

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Conditions:   Hypertension;   Cardiovascular Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting - verified September 2016

SRL (Sirolimus) Withdrawal

Conditions:   Acute Rejection of Liver Transplant;   Effects of Immunosuppressant Therapy
Intervention:   Drug: Sirolimus
Sponsor:   Northwestern University
Recruiting - verified September 2016

Open-label, Multi-center Protocol to Provide QTI571 to PAH Patients Who Participated in the Extension Study (A2301E1) in Japan

Condition:   Severe Pulmonary Arterial Hypertension
Intervention:   Drug: QTI571
Sponsor:   Novartis Pharmaceuticals
Active, not recruiting - verified September 2016

Comparative PK PD Study in PAH Patients (Fox vs. I-Neb)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: lloprost(Ventavis,BAYQ6252, 20 µg/mL);   Drug: lloprost(Ventavis,BAYQ6252, 10 µg/mL)
Sponsor:   Bayer
Active, not recruiting - verified September 2016

Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women

Conditions:   Menopause;   Aging
Interventions:   Drug: KUVAN;   Drug: Placebo;   Drug: Cetrotide;   Drug: Climara;   Drug: Placebo transdermal patch
Sponsors:   University of Colorado, Denver;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified September 2016

Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Interventions:   Drug: Macitentan;   Drug: Placebo
Sponsor:   Actelion
Active, not recruiting - verified September 2016

Roxadustat in the Treatment of Anemia in Chronic Kidney Disease (CKD) Patients, Not on Dialysis, in Comparison to Darbepoetin Alfa

Condition:   Anemia in Chronic Kidney Disease in Non-dialysis Patients
Interventions:   Drug: Roxadustat;   Drug: darbepoetin alfa
Sponsors:   Astellas Pharma Europe B.V.;   FibroGen
Recruiting - verified September 2016

Target Organ Damage and Polymorphisms Vav-2 and Vav-3 in Hypertensive Subjects

Condition:   Hypertension
Intervention:  
Sponsor:   Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Completed - verified September 2016

Efficacy of fimaSartan on arTerIal stiFFness iN patiEntS With HypertenSion

Condition:   Hypertension
Intervention:   Drug: Fimasartan
Sponsor:   Boryung Pharmaceutical Co., Ltd
Active, not recruiting - verified September 2016

Detection of Subclinical Atrial Fibrillation in High Risk Patients Using Implantable Loop Recorder

Conditions:   Arterial Hypertension;   Diabetes Mellitus
Interventions:   Other: Conventional Holter monitoring;   Device: Implantable loop recorder
Sponsor:   Axel Brandes
Completed - verified September 2016

The Impact of a Pre-Operative Exercise Program on Fitness Outcomes Following Bariatric Surgery

Condition:   Obesity
Intervention:   Other: 12 week Exercise Program
Sponsor:   University of Manitoba
Active, not recruiting - verified October 2015

The Alberta Vascular Risk Reduction Community Pharmacy Project: RxEACH

Conditions:   Diabetes;   Chronic Kidney Disease;   Established Atherosclerotic Vascular Disease;   Framingham Risk Score >20%
Intervention:   Other: Advanced Care
Sponsors:   University of Alberta;   Alberta Health & Wellness;   Alberta Health Services;   Merck Frosst Canada Ltd.
Completed - verified September 2016

Non-interventional Study on Compliance of Inhaled Treatment With Ventavis in Patient With Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Iloprost (Ventavis, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified September 2016

Evaluation of Sickle Cell Liver Disease

Condition:   Sickle Cell Disease
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified September 2016

Effects of Caloric Restriction in Obesity and Type 2 Diabetes

Conditions:   Type 2 Diabetes;   Obesity
Interventions:   Behavioral: Calorie restriction (25%);   Behavioral: Ad libitum health diet
Sponsors:   Mario Negri Institute for Pharmacological Research;   Istituto Superiore di Sanità
Recruiting - verified September 2016

Safety and Efficacy Study of HGP1207 in Patients With Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Systolic Dysfunction
Interventions:   Drug: Sildenafil;   Drug: Placebo
Sponsor:   Hanmi Pharmaceutical Company Limited
Recruiting - verified September 2016

A Feasibility Study to Evaluate the Effect of Concomitant Renal Denervation and Cardiac Ablation on AF Recurrence

Conditions:   Persistent Atrial Fibrillation;   Paroxysmal Atrial Fibrillation;   Hypertension
Interventions:   Device: Renal Artery Ablation;   Device: Cardiac Ablation
Sponsor:   St. Jude Medical
Active, not recruiting - verified September 2016

EnligHTN IV Trial - Multicenter Sham-controlled RCT of Renal Denervation for Hypertension

Condition:   Hypertension
Interventions:   Device: EnligHTN Renal Denervation;   Procedure: Sham
Sponsor:   St. Jude Medical
Active, not recruiting - verified September 2016

Trabeculectomy With Ologen Collagen Implant vs Trabeculectomy With Provisc in Steroid Induced Glaucoma

Condition:   Steroid Induced Glaucoma
Interventions:   Device: Ologen Collagen Matrix;   Drug: Provisc
Sponsors:   National Centre of Ophthalmology named after academician Zarifa Aliyeva;   Aeon Astron Europe B.V.
Completed - verified July 2015

Relaxin in Multiple Sclerosis (MS)

Condition:   Multiple Sclerosis, Relapsing-Remitting
Interventions:   Procedure: Blood Draw;   Procedure: Lumbar Puncture
Sponsors:   Providence Health & Services;   Providence Brain & Spine Institute; Microstein, LLC
Recruiting - verified September 2016

Registry to Evaluate the ROX COUPLER in Patients With Resistant or Uncontrolled Hypertension

Conditions:   Hypertension;   Blood Pressure, High;   Blood Pressure, Resistant;   Blood Pressure, Uncontrolled
Intervention:   Device: ROX COUPLER
Sponsor:   ROX Medical, Inc.
Recruiting - verified September 2016

Treatment of Resistant Hypertension by Renal Sympathetic Denervation in Patients Undergoing Dialysis Therapy

Condition:   Hypertension Secondary to Renal Disease
Intervention:   Procedure: Renal nerve denervation
Sponsors:   Turku University Hospital;   Oulu University Hospital;   Satakunta Central Hospital;   Central Finland Hospital District;   Vaasa Central Hospital, Vaasa, Finland
Terminated - verified September 2016

Roxadustat in the Treatment of Anemia in Chronic Kidney Disease Patients Not Requiring Dialysis

Condition:   Anemia in Chronic Kidney Disease in Non-dialysis Patients
Interventions:   Drug: Roxadustat;   Drug: Placebo
Sponsors:   Astellas Pharma Europe B.V.;   FibroGen
Recruiting - verified September 2016

Closed-loop Fluid Administration System: Pilot Study to Evaluate Feasibility

Condition:   Anesthesia
Interventions:   Drug: Open loop;   Device: Closed-loop
Sponsor:   Hopital Foch
Terminated - verified September 2016

A Study in Maintenance Kidney Transplant Recipients Following Conversion to Nulojix® (Belatacept)-Based

Condition:   Kidney Transplantation
Interventions:   Drug: Belatacept;   Drug: Tacrolimus;   Drug: Cyclosporine
Sponsor:   Bristol-Myers Squibb
Recruiting - verified June 2016

RAS Blockade at Bedtime Versus on Awakening for Aldosterone Breakthrough

Condition:   Chronic Kidney Disease
Intervention:   Other: Randomization that determine the time of treatment
Sponsor:   Centre Hospitalier Universitaire de Nice
Recruiting - verified September 2016

RCT of Stent Versus Standard Therapy in Oesophageal Variceal Haemorrhage

Condition:   Acute Bleeding Esophageal Varices
Interventions:   Device: Self-expanding mesh-metal oesophageal stent (SEMS);   Other: Standard Therapy
Sponsors:   University College, London;   Royal Free Hampstead NHS Trust;   Barts & The London NHS Trust;   University Hospitals Bristol NHS Foundation Trust
Completed - verified June 2015

Clinical Study to Evaluate the Effects of Macitentan on Exercise Capacity in Subjects With Eisenmenger Syndrome

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Macitentan 10 mg;   Drug: Placebo
Sponsor:   Actelion
Active, not recruiting - verified September 2016

Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisenmenger Syndrome

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Macitentan 10 mg tablet, once daily.
Sponsor:   Actelion
Enrolling by invitation - verified September 2016

Carotid Body Removal for the Treatment of Resistant Hypertension

Condition:   Hypertension
Intervention:   Procedure: Carotid body excision
Sponsor:   Noblewell
Completed - verified September 2016

Clinical Study to Evaluate the Antihypertensive Efficacy and Changes of Neurohormonal Markers of Fimasartan and Atenolol With Exaggerated Blood Pressure Response During Exercise in Essential Hypertensive Patients

Condition:   Hypertension
Interventions:   Drug: Fimasartan;   Drug: Atenolol
Sponsors:   Boryung Pharmaceutical Co., Ltd;   Severance Hospital
Completed - verified September 2016

Mitigation of Radiation Pneumonitis and Fibrosis

Conditions:   Lung Cancer;   Radiation Pneumonitis
Interventions:   Drug: Enalapril;   Drug: placebo
Sponsor:   VA Office of Research and Development
Recruiting - verified September 2016

A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn

Condition:   Pulmonary Hypertension, Familial Persistent, of the Newborn
Interventions:   Drug: placebo;   Drug: iv sildenafil
Sponsor:   Pfizer
Recruiting - verified September 2016

A Multicenter Study to Evaluate the ROX Arteriovenous Coupler in Patients With Treatment-Resistant Hypertension

Condition:   Hypertension
Intervention:   Device: ROX COUPLER
Sponsor:   ROX Medical, Inc.
Active, not recruiting - verified September 2016

Safety And Efficacy Of Sildenafil In Children With Pulmonary Arterial Hypertension

Conditions:   Pulmonary Arterial Hypertension;   Hypertension, Pulmonary
Intervention:   Drug: Sildenafil
Sponsor:   Pfizer
Recruiting - verified September 2016

Efficacy, Safety and Tolerability of Multiple Doses of Valsartan in Children With Hypertension With or Without CKD

Condition:   Pediatric Hypertension With or Without CKD
Interventions:   Drug: VAL489;   Drug: VAL489 matching placebo
Sponsor:   Novartis Pharmaceuticals
Recruiting - verified September 2016

Post-Authorisation Safety Cohort Observation of RetacritTM (Epoetin Zeta) Administered Subcutaneously for the Treatment of Renal Anaemia

Conditions:   Renal Anemia;   Pregnancy;   Lactation
Intervention:  
Sponsors:   Pfizer;   Hospira, Inc.
Recruiting - verified September 2016

Mobile Phone in Hypertension Management

Condition:   Hypertension
Intervention:   Device: Mobile phone-based self-report system, electronic Patient-Reported Outcomes Measure (e-PROM)
Sponsor:   Göteborg University
Completed - verified September 2016

Renal Sympathectomy in Treatment Resistant Essential Hypertension, a Sham Controlled Randomized Trial

Condition:   Hypertension
Interventions:   Procedure: Renal artery ablation;   Procedure: Renal angiography
Sponsors:   Aarhus University Hospital Skejby;   Aarhus University Hospital;   Regionshospitalet Silkeborg;   Randers Regional Hospital;   Regional Hospital Holstebro;   Central Jutland Regional Hospital
Completed - verified September 2016

52-104 Week Off-therapy Second Extension to Study CSPP100A2365

Condition:   Hypertension
Intervention:  
Sponsor:   Novartis
Recruiting - verified September 2016

Glaucoma Eye Drop Instillation: Impact of Education

Condition:   Glaucoma, Open-Angle
Interventions:   Other: Video education on proper eye drop instillation technique;   Other: Placebo video education on healthy eating tips
Sponsor:   Northwestern University
Active, not recruiting - verified September 2016

Treadmill Exercise and GM-CSF Study to Improving Functioning in Peripheral Artery Disease (PAD)

Condition:   Peripheral Arterial Disease
Interventions:   Behavioral: Supervised Treadmill Exercise Therapy;   Other: Health education sessions (Control);   Drug: granulocyte macrophage colony stimulating factor (GM-CSF)
Sponsors:   Northwestern University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified September 2016

Inhaled Iloprost in the Treatment of Patients With Pulmonary Hypertension up to 4 Years

Condition:   Pulmonary Hypertension
Intervention:   Drug: Ventavis inhaled (Iloprost, BAYQ6256)
Sponsor:   Bayer
Active, not recruiting - verified September 2016

Vasopressin and Inhaled Prostacyclin in Pediatric Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Interventions:   Drug: Vasopressin infusion;   Drug: Vasopressin infusion and epoprostenol inhalation
Sponsor:   University of Alberta
Terminated - verified September 2016

Real-time MRI Right Heart Catheterization Using Passive Catheters

Conditions:   Caridovascular Disease;   Congenital Heart Disease;   Pulmonary Hypertension
Interventions:   Device: Balloon catheter for right heart catheterization;   Drug: Gadopentate Dimeglumine (Gadolinium); Contrast Agent;   Procedure: Right Heart Catheterization;   Procedure: Cardiac Real-time MRI;   Procedure: Vascular Hemostasis
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified September 2016

Study in Subjects With PAH and PH Secondary to IPF Using Inhaled GeNOsyl.

Conditions:   Pulmonary Arterial Hypertension;   Idiopathic Pulmonary Fibrosis
Interventions:   Drug: Inhaled Nitric Oxide;   Drug: Inhaled Nitric Oxide;   Drug: Inhaled Nitric Oxide
Sponsor:   Geno LLC
Completed - verified September 2016

Study of the Effect of Intradialytic Vasopressin on Chronic Hypertension in Patients With End Stage Renal Disease

Conditions:   Hypertension;   End Stage Renal Disease
Interventions:   Drug: Vasopressin - Very Low Dose;   Drug: Vasopressin - Low Dose;   Drug: Placebo Comparator
Sponsor:   Anjali Ganda, MD
Recruiting - verified September 2016

A Regulatory Requirement Post-Marketing Surveillance Study to Monitor the Safety and Efficacy of Twynsta (Telmisartan + Amlodipine SPC, q.d.) in Korean Hypertensive Patients Requiring Combination Therapy

Condition:   Hypertension
Intervention:   Drug: Twynsta tablet
Sponsor:   Boehringer Ingelheim
Completed - verified September 2016

Grain Exercise Trial - Whole Grain Versus no Grain With or Without Physiotherapy-promoted Exercise for Waist Loss

Conditions:   Abdominal Obesity;   Cardiovascular Diseases;   Diabetes Type 2;   Hypertension;   Overweight
Interventions:   Behavioral: Diet A;   Behavioral: Diet B;   Behavioral: Physiotherapy
Sponsors:   Lund University;   Region Skane
Completed - verified September 2016

Carvedilol for Pre-primary Prophylaxis of Esophageal Varices in Cirrhosis

Condition:   Cirrhosis
Interventions:   Drug: carvedilol;   Drug: Placebo
Sponsor:   Institute of Liver and Biliary Sciences, India
Recruiting - verified September 2016

Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, Mali

Condition:   Malaria
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified September 2016

Longitudinal Study of Mitochondrial Hepatopathies

Conditions:   Acute Liver Failure,;   Mitochondrial Diseases;   End Stage Liver Disease,;   Respiratory Chain Deficiencies, Mitochondrial;   Disorder of Fatty Acid Oxidation
Intervention:  
Sponsors:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   University of Michigan
Recruiting - verified September 2016

Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)

Condition:   Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Interventions:   Biological: Rituximab;   Other: Placebo
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified September 2016

Post-authorization Safety Study of Etoricoxib and Other Anti-inflammatory Therapies in European Patients With Ankylosing Spondylitis (MK-0663-163)

Condition:   Ankylosing Spondylitis
Intervention:  
Sponsor:   Merck Sharp & Dohme Corp.
Active, not recruiting - verified September 2016

Chiropractic for Hypertension in Patients

Condition:   Hypertension
Interventions:   Other: Spinal Manipulation;   Other: Sham Spinal Manipulation
Sponsor:   Palmer College of Chiropractic
Completed - verified September 2016

Safety and Efficacy Study of Bosentan in Progressive Pulmonary Sarcoidosis

Conditions:   Sarcoidosis;   Pulmonary Hypertension
Interventions:   Drug: bosentan;   Drug: placebo
Sponsor:   Daniel Doberer
Terminated - verified September 2016

Sildenafil for Secondary Pulmonary Hypertension Due to Valvular Disease

Conditions:   Pulmonary Hypertension;   Valvular Heart Disease
Interventions:   Drug: Sildenafil Citrate;   Drug: Placebo
Sponsors:   Hospital General Universitario Gregorio Marañon;   Instituto de Salud Carlos III;   Fundación de Investigación en Red en Enfermedades Cardiovasculares
Completed - verified September 2016

Genetics of Type 2 Diabetes Among Han Chinese

Conditions:   Diabetes;   Obesity;   Hypertension;   Retinopathy;   Nephropathy
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Completed - verified September 2016

Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC)

Conditions:   Liver Diseases;   Alagille Syndrome;   Alpha 1-Antitrypsin Deficiency
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified September 2016

Preventing Microalbuminuria in Type 2 Diabetes

Condition:   Diabetes
Interventions:   Drug: Benazepril;   Drug: Valsartan;   Drug: Benazepril/Valsartan
Sponsors:   Mario Negri Institute for Pharmacological Research;   Agenzia Italiana del Farmaco
Completed - verified September 2016

Model System for Transient Forearm Blood Vessel Dysfunction

Conditions:   Limb Ischemia;   Ischemic Preconditioning
Interventions:   Procedure: Limb Ischemia;   Drug: Acetylcholine
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified February 2009

Study to Determine if Taking OTC Non-Steroidal Anti-Inflammatory Affects Eye Pressure in Patients Using Glaucoma Drops

Conditions:   Glaucoma;   Ocular Hypertension
Interventions:   Drug: ibuprofen, latanoprost, brimonidine;   Drug: Ibuprofen, brimonidine, latanoprost;   Drug: Ibuprofen
Sponsors:   Philadelphia Eye Associates;   Pfizer
Completed - verified September 2016

Pulmonary Hypertension in Patients With Sickle Cell Disease in Nigeria

Conditions:   Secondary Pulmonary Arterial Hypertension;   Sickle Cell Disease;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified September 2016

Omega-3 Fatty Acid Supplementation to Prevent Preterm Birth in High Risk Pregnancies

Condition:   Preterm Birth
Intervention:   Drug: 17 alpha-Hydroxyprogesterone Caproate and Omega-3 fish oils
Sponsors:   The George Washington University Biostatistics Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed - verified September 2016

Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS)

Conditions:   Preterm Birth;   Pregnancy;   Multifetal
Intervention:   Drug: 17 alpha-hydroxyprogesterone caproate (17P)
Sponsors:   The George Washington University Biostatistics Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed - verified September 2016

Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia

Conditions:   Pulmonary Hypertension;   Sickle Cell Anemia;   Sickle Cell Disease
Intervention:  
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified September 2016

Metabolic Differences of Overweight Children and Children of Overweight Parents

Condition:   Obesity
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting - verified September 2016