High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Study of CS-3150 in Patients With Severe Hypertension

Condition:   Severe Hypertension
Intervention:   Drug: CS-3150
Sponsor:   Daiichi Sankyo Co., Ltd.
Not yet recruiting - verified June 2016

Non-inferiority of PRO-067 Ophthalmic Solution vs GAAP Ofteno® in Glaucoma or Ocular Hypertension

Conditions:   Primary Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: PRO-067;   Drug: GAAP Ofteno®
Sponsor:   Laboratorios Sophia S.A de C.V.
Recruiting - verified May 2016

MASked-unconTrolled hypERtension Management Based on Office BP or on Out-of-office (Ambulatory) BP Measurement

Condition:   Masked Hypertension
Interventions:   Other: Optimization of antihypertensive treatment based on office BP;   Other: Optimization of antihypertensive treatment based on 24-hour ABPM
Sponsors:   Istituto Auxologico Italiano;   European Society of Hypertension
Not yet recruiting - verified June 2016

Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A)

Condition:   Retinal Disease
Intervention:   Device: optical coherence tomography angiography
Sponsor:   University Hospital Inselspital, Berne
Not yet recruiting - verified June 2016

Study of CS-3150 in Combination With ARB or ACE Inhibitor in Hypertensive Patients With Moderate Renal Impairment

Condition:   Hypertension With Moderate Renal Impairment
Intervention:   Drug: CS-3150
Sponsor:   Daiichi Sankyo Co., Ltd.
Not yet recruiting - verified June 2016

Study of CS-3150 in Hypertensive Patients With Type 2 Diabetes and Albuminuria

Condition:   Hypertension With Type 2 Diabetes and Albuminuria.
Intervention:   Drug: CS-3150
Sponsor:   Daiichi Sankyo Co., Ltd.
Not yet recruiting - verified June 2016

Bleeding Frequency Under Anticoagulant Treatment in Pulmonary Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Oral anticoagulant treatment
Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
Not yet recruiting - verified June 2016

Implementation of a Population Health Chronic Disease Management Program

Conditions:   Diabetes Mellitus;   Cardiovascular Diseases;   Hypertension
Intervention:   Other: Centralized support for population health management activities
Sponsor:   Massachusetts General Hospital
Completed - verified June 2016

Study to Assess Safety and Efficacy of Ifetroban for Treatment of Portal Hypertension in Cirrhotic Patients

Conditions:   Portal Hypertension;   Liver Cirrhosis
Interventions:   Drug: Ifetroban;   Drug: Placebo
Sponsor:   Cumberland Pharmaceuticals
Not yet recruiting - verified June 2016

Controlling And Lowering Blood Pressure With the MobiusHDTM Device

Condition:   Hypertension
Interventions:   Device: MobiusHD;   Other: Sham Implantation
Sponsor:   Vascular Dynamics, Inc.
Not yet recruiting - verified June 2016

Technology-augmented Self-monitoring Model Among Patients With Type 2 Diabetes and Hypertension

Conditions:   Type 2 Diabetes Mellitus;   Hypertension
Intervention:   Device: Technology-based self-management model
Sponsor:   The University of Hong Kong
Recruiting - verified June 2016

Evaluation of Anxiety in Surgery Preoperative Area (ASDT)

Condition:   Preoperative Area
Intervention:   Other: Questionnaires
Sponsor:   Hospices Civils de Lyon
Active, not recruiting - verified June 2016

The Role of Intravenous Albumin Replacement During Abdominal Paracentesis in Patients With Malignancy Related Ascites

Conditions:   Ascites;   Hypotension
Interventions:   Procedure: Receives IV albumin infusion;   Biological: Do not receive IV albumin infusion
Sponsor:   National University Hospital, Singapore
Recruiting - verified June 2016

Apalutamide Plus Intermittent Hormone Therapy Versus Intermittent Hormone Therapy Alone in Prostate Cancer

Condition:   Prostate Cancer
Interventions:   Drug: Apalutamide;   Drug: IHT
Sponsors:   Robert J Amato;   Janssen Scientific Affairs, LLC
Not yet recruiting - verified June 2016

Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism

Condition:   Hyperthyroidism
Intervention:   Drug: thionamide treatment for 3 months
Sponsor:   Hu Hao
Not yet recruiting - verified June 2016

Integrated Primary Care for Diabetes and Cardiovascular Disease

Conditions:   Diabetes Mellitus;   Hypertension;   Heart Failure;   Ischemic Heart Disease;   Cerebrovascular Disease
Interventions:   Behavioral: Outreach education training;   Behavioral: No outreach education training
Sponsors:   University of Sao Paulo General Hospital;   University of Sao Paulo;   Santa Catarina Federal University;   University of Cape Town;   Federal University of Bahia;   Medical Research Council, South Africa;   University of East Anglia
Not yet recruiting - verified June 2016

The Risk Factors of Symptomatic Gallbladder Stone: Age-Sex Matched Case-control Study Performed in Single Institute

Condition:   Gallstone
Intervention:  
Sponsor:   Cheju Halla General Hospital
Completed - verified June 2016

Study to Evaluate CORT125134 in Patients With Cushing's Syndrome

Condition:   Cushing's Syndrome
Intervention:   Drug: CORT125134
Sponsor:   Corcept Therapeutics
Not yet recruiting - verified June 2016

Sildenafil Administration to Treat Neonatal Encephalopathy

Condition:   Neonatal Encephalopathy
Interventions:   Drug: Sildenafil;   Drug: Ora-Blend
Sponsor:   McGill University Health Center
Not yet recruiting - verified June 2016

Bioequivalence Study (Candesartan 16 mg and Amlodipine 5 mg) - A

Condition:   Hypertension
Interventions:   Drug: CKD-330 16/5mg - A;   Drug: Candesartan 16mg and Amlodipine 5mg
Sponsor:   Chong Kun Dang Pharmaceutical
Completed - verified June 2016

Bioequivalence Study (Candesartan 16 mg and Amlodipine 5 mg) - B

Condition:   Hypertension
Interventions:   Drug: CKD-330 16/5mg - B;   Drug: Candesartan 16mg and Amlodipine 5mg
Sponsor:   Chong Kun Dang Pharmaceutical
Completed - verified June 2016

Increasing Risk Perception of Physical Activity Using Patient-targeted Feedback: Randomized Controlled Trial.

Conditions:   Hypertension;   Coronary Disease;   Cardiac Diseases
Interventions:   Behavioral: Patient-targeted individual physical-activity-feedback;   Device: Pedometer
Sponsor:   Universitätsklinikum Hamburg-Eppendorf
Not yet recruiting - verified June 2016

Plasma Aldosterone Levels and Atrial Fibrillation Reduction (ALDO-AF Study)

Conditions:   Atrial Fibrillation;   Aldosterone
Intervention:  
Sponsor:   University Hospital, Caen
Recruiting - verified June 2016

3D Imaging: Prognostic Role in Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Device: 3D right ventricular imaging echocardiographic
Sponsor:   Centre Hospitalier Universitaire de Nice
Recruiting - verified May 2016

Women Specific Cardiac Recovery After Preeclampsia

Conditions:   Pre-Eclampsia;   Pregnancy
Intervention:   Other: Venapunction
Sponsor:   Maastricht University Medical Center
Not yet recruiting - verified April 2016

Comparison of His Bundle Pacing and Bi-Ventricular Pacing in Heart Failure With Atrial Fibrillation

Conditions:   Heart Failure;   Atrial Fibrillation
Interventions:   Device: CRT Device and Bi-ventricular pacing;   Device: CRT Device and His-bundle Pacing
Sponsors:   First Affiliated Hospital of Wenzhou Medical Univeristy;   HT-Med Company;   Chinese Academy of Medical Sciences, Fuwai Hospital;   Shanghai Zhongshan Hospital;   Jiangsu People's Hospital;   Wuhan Asia Heart Hospital;   Sir Run Run Shaw Hospital;   Shanxi People's Hospital
Recruiting - verified June 2016

E_Stethoscope: Portable Digital Auscultation Study on Hypertensive/Hypertensive Heart Disease Patients

Conditions:   Hypertension;   Hypertensive Heart Disease
Interventions:   Other: Electrocardiogram/Echocardiography;   Other: Portable digital auscultation
Sponsor:   National Heart Centre Singapore
Recruiting - verified May 2016

The in Vivo Effect of Medical and Surgical Glaucoma Treatments on the Schlemm's Canal Micro-structure

Conditions:   Glaucoma;   Cataract
Intervention:   Device: Optical coherence tomography imaging
Sponsor:   Sheba Medical Center
Not yet recruiting - verified June 2016

The Effects of Aronia Juice Polyphenols on Cardiovascular Disease Risk

Conditions:   Hypertension;   Overweight
Interventions:   Dietary Supplement: Pure Aronia juice;   Dietary Supplement: Aronia juice-based beverage;   Dietary Supplement: Placebo beverage
Sponsors:   University of Belgrade;   Clinical Hospital Center Zemun
Active, not recruiting - verified June 2016

Ahmed Glaucoma Valve Surgery With Mitomycin-C

Conditions:   Glaucoma;   Primary Open Angle Glaucoma;   Secondary Glaucoma;   Neovascular Glaucoma
Interventions:   Drug: Mitomycin-C;   Other: Balanced Salt Solution
Sponsors:   University of California, San Francisco;   Bascom Palmer Eye Institute;   University of North Carolina;   University of Colorado, Denver;   University of Maryland;   Zhongshan Ophthalmic Center;   Asociación para Evitar la Ceguera en México
Not yet recruiting - verified June 2016

Associations of Vitamin D Receptor ApaI and Tru9I Polymorphisms With the Risk of Primary Open-angle Glaucoma

Condition:   Primary Open- Angle Glaucoma
Intervention:   Other: Vitamin D receptor polymorphic analysis
Sponsors:   Lv Yingjuan;   Tianjin Medical University Eye Hospital
Completed - verified June 2016

Reducing Diagnostic Errors in Primary Care Pediatrics (Project RedDE)

Condition:   Diagnostic Errors
Intervention:   Behavioral: Quality Improvement Collaborative
Sponsors:   Montefiore Medical Center;   American Academy of Pediatrics
Recruiting - verified March 2016

Pilot Study of Aprepitant Effect on Aldosterone Secretion in Diabetic Patient (Diabetes Mellitus) With Hypertension Associated With Low Renin

Conditions:   Type 2 Diabetes;   Hypertension
Interventions:   Biological: Blood sampling;   Procedure: Blood Pressure Measurement;   Device: electrocardiogram;   Procedure: orthostatic test;   Drug: Administration of Aprepitant;   Drug: Administration of placebo
Sponsor:   University Hospital, Rouen
Not yet recruiting - verified June 2016

Evaluation of Postoperative Ascites After Somatostatin Infusion Following Hepatectomy for Hepatocellular Carcinoma by Laparotomy

Condition:   Hepatocellular Carcinoma
Interventions:   Drug: somatostatin infusion;   Drug: placebo infusion
Sponsor:   Hospices Civils de Lyon
Not yet recruiting - verified June 2016

24-hour Efficacy and Ocular Surface With Talfuprost and Triple Combined Therapy

Conditions:   Glaucoma;   Ocular Surface Disease
Interventions:   Drug: tafluprost;   Drug: tafluprost and dorzolamide/timolol
Sponsor:   Aristotle University Of Thessaloniki
Completed - verified June 2016

Low Dose Aspirin in the Prevention of Preeclampsia in China

Condition:   Preeclampsia
Interventions:   Drug: Aspirin;   Other: Blank
Sponsor:   Peking University First Hospital
Recruiting - verified June 2016

Evaluation of the Efficacy of Citrulline Supplementation on the Delay of Delivery for Women Hospitalized for Moderate or Severe Pre-eclampsia (CITRUPE)

Conditions:   Pre-eclampsia;   Pregnancy
Interventions:   Drug: Citrulline;   Drug: Placebo
Sponsor:   Nantes University Hospital
Not yet recruiting - verified June 2016

BEhavior of Biomarkers During pregnanCy and lactatiOn Through a Biological Multi-paradigm modEl. BECOME Study Protocol

Conditions:   Pregnancy;   Gestational Diabetes;   Hypertension;   Obesity
Intervention:   Other: BEhavior of biomarkers during pregnanCy and lactatiOn
Sponsor:   Universidad de Granada
Recruiting - verified June 2016

The Treatment of Hepatocirrhosis and Portal Hypertension

Condition:   Hepatic Cirrhosis
Intervention:   Procedure: PSE
Sponsors:   Yanjing Gao;   Shandong Provincial Hospital;   Jinan Military General Hospital
Recruiting - verified May 2016

Open-label, Single Arm Trial of BI 695502 in Patients With Previously Untreated Metastatic Colorectal Cancer

Condition:   Colorectal Neoplasms
Interventions:   Drug: BI 695502;   Drug: chemotherapy
Sponsor:   Boehringer Ingelheim
Not yet recruiting - verified June 2016

Sympathetic Mapping/ Ablation of Renal Nerves Trial

Condition:   Hypertension
Intervention:   Device: SyMapCath I™ catheter and SYMPIONEER S1™ Stimulator/Generator
Sponsors:   SyMap Medical (Suzhou), Ltd.;   Tigermed Consulting Co., Ltd
Not yet recruiting - verified February 2016

A Long-term Extension Study of Riociguat in Patients With Symptomatic Pulmonary Arterial Hypertension.

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Adempas (Riociguat, BAY63-2521)
Sponsor:   Bayer
Recruiting - verified June 2016

Effects of Preoperative Fasting on ECG and Vital Parameters

Conditions:   Fasting;   Intraoperative Complications;   Ischemia
Interventions:   Other: Preoperative Fasting for 8 hours;   Other: Preoperative Fasting for more than 12 hours;   Drug: Spinal Anesthesia with Bupivacaine
Sponsor:   Bozyaka Training and Research Hospital
Recruiting - verified June 2016

RCT of pH-Controlled Late Permissive Hypercapnia for Intubated and Ventilated Preterm Infants

Condition:   Premature Neonate
Interventions:   Other: Higher permissive hypercapnia;   Other: Lower Permissive Hypercapnia
Sponsor:   University of Alabama at Birmingham
Recruiting - verified April 2016

Development of a Next Generation Sequencing (NGS) -Based Assay to Detect Preeclampsia Molecular Markers

Condition:   Preeclampsia
Intervention:  
Sponsor:   Illumina, Inc.
Recruiting - verified June 2016

Pilot - Peri-operative Beta Blockade

Conditions:   Adrenergic Beta-Receptor Blockader;   Troponin Levels;   Cardiomyopathy, Post-surgical
Intervention:   Drug: metoprolol
Sponsor:   Washington University School of Medicine
Recruiting - verified June 2016

Safety and Efficacy of SIMBRINZA® BID as an Adjunctive to DUOTRAV®

Conditions:   Open-angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Brinzolamide 1%/Brimonidine 0.2% suspension;   Drug: Brinzolamide/Brimonidine vehicle;   Drug: Travoprost 0.004%/Timolol 0.5% solution
Sponsor:   Alcon Research
Recruiting - verified June 2016

Endtidal Ethanol in Sclerotherapy

Condition:   Ethanol Concentration
Intervention:   Device: Alcomed 3011®
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified June 2016

The Natriuretic Peptide System in African-Americans.

Conditions:   Healthy;   Prehypertension
Interventions:   Dietary Supplement: Low-Salt Diet;   Dietary Supplement: High-Salt Diet
Sponsor:   Vanderbilt University
Recruiting - verified June 2016

PDA Post NICU Discharge

Condition:   Patent Ductus Arteriosus
Intervention:  
Sponsor:   Mednax Center for Research, Education and Quality
Recruiting - verified June 2016

SD-OCT Multimodal Analysis in GLaucoma

Conditions:   Glaucoma;   Ocular Hypertension;   Eye Diseases
Intervention:   Device: SD-OCT Spectralis
Sponsor:   University Hospital, Bordeaux
Recruiting - verified June 2016

WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study)

Conditions:   Williams Syndrome;   Cardiovascular Disease;   Multisystem Developmental Disorder;   Elastin Gene Deletion;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified June 2016

Prevalence of Obstructive Sleep Apnoea in Glaucoma

Conditions:   Obstructive Sleep Apnoea;   Open Angle Glaucoma
Intervention:  
Sponsors:   Papworth Hospital NHS Foundation Trust;   Anglia Ruskin University;   Hinchingbrooke Healthcare NHS Trust
Recruiting - verified June 2016

A Study of the ReCor Medical Paradise System in Clinical Hypertension

Conditions:   Hypertension;   Vascular Diseases
Interventions:   Device: The Paradise® Renal Denervation Ultrasound System;   Device: Sham Procedure
Sponsor:   ReCor Medical, Inc.
Recruiting - verified March 2016

An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease;   Combined Pulmonary Fibrosis and Emphysema
Intervention:   Drug: Inhaled Treprostinil
Sponsor:   United Therapeutics
Enrolling by invitation - verified June 2016

Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease;   Combined Pulmonary Fibrosis and Emphysema
Interventions:   Drug: Inhaled Treprostinil;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting - verified June 2016

AIH-induced Walking Recovery After Subacute SCI

Condition:   Spinal Cord Injury
Interventions:   Other: Daily acute intermittent hypoxia (dAIH);   Other: dSHAM;   Other: Walking
Sponsors:   Emory University;   United States Department of Defense
Recruiting - verified June 2016

Twitter and CV Health

Conditions:   Cardiovascular Disease;   Hypertension
Intervention:   Behavioral: Health System: HTN Intervention
Sponsor:   University of Pennsylvania
Not yet recruiting - verified June 2016

Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer

Conditions:   Breast Carcinoma;   Hypertension
Intervention:   Other: Laboratory Biomarker Analysis
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified June 2016

Clinical Study to Explore the Effects of Actelion's Latest Endothelin Receptor Antagonist (ERA) - at Different Dose Strengths - on the Efficacy, Safety and Tolerability in Subjects With Essential Hypertension

Condition:   Essential Hypertension
Interventions:   Drug: ERA;   Drug: Lisinopril;   Other: Placebo
Sponsor:   Actelion
Recruiting - verified June 2016

Open Label Extension of LipoLat-CS202

Condition:   Glaucoma
Intervention:   Other: None in this study
Sponsor:   Peregrine Ophthalmic
Completed - verified June 2016

Protein Supplementation in Thiazide-induced Hyponatremia

Conditions:   Hyponatremia;   Hypertension;   Blood Pressure
Intervention:   Dietary Supplement: Nepro
Sponsor:   Ottawa Hospital Research Institute
Recruiting - verified June 2016

Optimal HCTZ Cessation for Diagnosis of Hyperparathyroidism

Condition:   Hyperparathyroidism
Intervention:   Procedure: NO hydrochlorothiazide (HCTZ)
Sponsor:   University of Missouri-Columbia
Recruiting - verified June 2016

Carbidopa for the Treatment of Excessive Blood Pressure Variability

Conditions:   Dysautonomia, Familial;   Baroreflex Failure Syndrome
Interventions:   Drug: Carbidopa Low Dose;   Other: Placebo;   Drug: Carbidopa High Dose
Sponsor:   New York University School of Medicine
Recruiting - verified June 2016

Egypt Hypertension Study

Condition:   Different Classes of the Antihypertensive Treatment.
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified June 2016

Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF

Conditions:   Heart Failure, Left-Sided;;   Diastolic Heart Failure;   Hypertension
Intervention:   Drug: regadenoson
Sponsors:   Marvin W. Kronenberg, M.D.;   Astellas Pharma US, Inc.
Recruiting - verified June 2016

Electronic Activity Level Monitoring Pilot in Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Hypertension, Pulmonary
Intervention:   Other: Correlation assessment
Sponsor:   Bayer
Recruiting - verified June 2016

Chemical Block and Electrical Stimulation of the Carotid Body to Treat Refractory Hypertension

Condition:   Hypertension
Interventions:   Device: Electrical block;   Device: Chemical block
Sponsor:   Eric Albrecht
Recruiting - verified June 2016

Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Hyperoxaluria and Kidney Stones

Conditions:   Secondary Hyperoxaluria;   Nephrolithiasis;   Kidney Stones;   Hyperoxaluria;   Dietary Hyperoxaluria
Interventions:   Drug: ALLN-177 low dose;   Drug: ALLN-177 mid dose;   Drug: ALLN-177 high dose;   Drug: Placebo
Sponsor:   Allena Pharmaceuticals
Active, not recruiting - verified June 2016

Study to Assess the Tolerability and the Safety of the Transition From Inhaled Treprostinil to Oral Selexipag in Patients With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Selexipag
Sponsor:   Actelion
Active, not recruiting - verified June 2016

Real Evidence of Anticoagulation Treatment in Non-valvular Atrial Fibrillation in Germany and the UK: REACT-AF2

Condition:   Non-valvular Atrial Fibrillation
Intervention:  
Sponsors:   Bristol-Myers Squibb;   IMS Health;   Oxon Epidemiology
Active, not recruiting - verified June 2016

Effects of Iloprost on Pulmonary Hemodynamics and Oxygenation in Patients of Chronic Obstructive Pulmonary Disease During One-lung Ventilation

Conditions:   Video-assisted Thoracoscopic Surgery;   Chronic Obstructive Pulmonary Disease
Interventions:   Drug: Inhaled iloprost;   Drug: normal saline (Saline 0.9%)
Sponsor:   Yonsei University
Completed - verified June 2016

Prospective, Non-interventional, Multi-center, Post-authorization Safety Study of Riociguat for Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Recruiting - verified June 2016

Blood Pressure Control of Nifedipine GITS 60mg Treatment in Chinese Hypertensive Subjects Uncontrolled on Starting-dose Mono-therapyo-therapy.

Condition:   Hypertension
Intervention:   Drug: Nifedipine(Adalat_BAY1040)
Sponsor:   Bayer
Recruiting - verified June 2016

Renal Denervation Using the Vessix Renal Denervation System for the Treatment of Hypertension (REDUCE HTN:REINFORCE)

Condition:   Hypertension
Interventions:   Device: Renal Denervation (Vessix);   Device: Renal Angiography
Sponsor:   Boston Scientific Corporation
Recruiting - verified June 2016

Added Value of Speckle Tracking in the Evaluation of Patients With Sickle Cell Disease

Condition:   Sickle Cell Disease
Interventions:   Other: Cardiac echography;   Other: Biological parameters;   Other: Clinical parameters
Sponsor:   Brugmann University Hospital
Recruiting - verified June 2016

The Pharmacokinetic Drug Interaction Between Rosuvastatin and Telmisartan/Amlodipine

Conditions:   Hypertension;   Hyperlipidemia
Interventions:   Drug: Rosuvastatin;   Drug: Telmisartan/Amlodipine;   Drug: Rosuvastatin and Telmisartan/Amlodipine
Sponsor:   Jeil Pharmaceutical Co., Ltd.
Completed - verified March 2015

Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients

Condition:   Glaucoma, Neovascular
Interventions:   Drug: Aflibercept (Eylea, BAY 86-5321);   Drug: Sham Injection
Sponsors:   Bayer;   Regeneron Pharmaceuticals
Recruiting - verified June 2016

Non Invasive Measurements of Intracranial Pressure in Patients With Malignant Glioma

Condition:   Glioma
Intervention:   Device: noninvasive method of ICP measurements (Elios)
Sponsors:   Centre Jean Perrin;   Laboratoire de Biophysique Neurosensorielle - UMR INSERM 1107 (Pr Paul AVAN)
Recruiting - verified June 2016

TIPS in Fundal Variceal Bleeding (the TFB Study)

Conditions:   Portal Hypertension;   Bleeding Gastric Varices
Intervention:   Device: Early TIPS
Sponsors:   Institut d'Investigacions Biomèdiques August Pi i Sunyer;   Hospital Clinic of Barcelona;   Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau;   Germans Trias i Pujol Hospital;   Hospital Universitario Ramon y Cajal;   Hospital del Mar
Recruiting - verified June 2016

Natural History and Biology of Long-Term Late Effects Following Hematopoietic Cell Transplant for Childhood Hematologic Malignancies

Conditions:   Acute Lymphoblastic Leukemia/Lymphoma;   Myelodysplasia;   Acute Myelogenous Leukemia;   Juvenile Myelomonocytic Leukemia;   Chronic Myelogenous Leukemia
Intervention:  
Sponsors:   Center for International Blood and Marrow Transplant Research;   Pediatric Blood and Marrow Transplant Consortium;   National Marrow Donor Program
Recruiting - verified June 2016

Dysregulation of Lipid Metabolism and Right Ventricular Function in PAH

Condition:   Pulmonary Arterial Hypertension
Interventions:   Procedure: Blood Sampling;   Other: Cardiac MRI
Sponsor:   Vanderbilt University
Recruiting - verified June 2016

Tailored Treatment to Enhance Risk Perception in Sleep Apnea

Condition:   Obstructive Sleep Apnea (OSA)
Interventions:   Behavioral: Brief Personalized Video (BPV);   Behavioral: Non-Personalized Video (NPV);   Behavioral: Treatment as Usual (TAU)
Sponsors:   National Jewish Health;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified June 2016

A Novel Closed-loop Integrated System for the Maintenance of Haemodynamic Stability

Condition:   Hypotension
Interventions:   Device: vasopressor delivery automated system w/;   Drug: phenylephrine;   Drug: ephedrine;   Device: manual vasopressor delivery
Sponsor:   KK Women's and Children's Hospital
Recruiting - verified March 2016

Safety, Tolerability, and Pharmacokinetics of Oral Treprostinil in Pediatric PAH Patients Aged 7 to 17 Years

Condition:   PAH
Intervention:   Drug: oral treprostinil
Sponsor:   United Therapeutics
Recruiting - verified June 2016

Impact on Morbidity and Mortality of Prophylactic Dosing of Low Molecular Weight Heparin in Child-Pugh B Cirrhotic Patients: a Randomized Controlled Study

Condition:   Cirrhosis
Intervention:   Drug: Enoxaparine
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting - verified June 2016

Phase III Trial BI 695502 Plus Chemotherapy vs. Avastin® Plus Chemotherapy in Patients With Lung Cancer

Condition:   Carcinoma, Non-Small-Cell Lung
Interventions:   Drug: Chemotherapy;   Drug: BI 695502;   Drug: bevacizumab;   Drug: Chemotherapy
Sponsor:   Boehringer Ingelheim
Recruiting - verified June 2016

Exploratory, 2-Part Study to Assess Pulsed Inhaled Nitric Oxide on Functional Pulmonary Imaging Parameters in Subjects With WHO Grp 3 Pulmonary Hypertension Associated With COPD on LTOT (Part 1) and IPF on LTOT (Part 2)

Conditions:   Pulmonary Hypertension;   Chronic Obstructive Pulmonary Disease;   Idiopathic Pulmonary Fibrosis
Interventions:   Drug: inhaled NO - 30 mcg/kg IBW/hr [4880 ppm];   Drug: inhaled NO - 25 mcg/kg IBW/hr [2440 ppm] - Seq 1;   Drug: inhaled NO - 25 mcg/kg IBW/hr [4880 ppm] - Seq 1;   Drug: inhaled NO - 25 mcg/kg IBW/hr [4880 ppm] - Seq 2;   Drug: inhaled NO - 25 mcg/kg IBW/hr [2440 ppm] - Seq 2
Sponsor:   Bellerophon
Recruiting - verified June 2016

Hypoxia and Inflammatory Injury in Human Renovascular Hypertension

Conditions:   Renal Artery Stenosis;   Ischemic Nephropathy;   Renovascular Disease;   Chronic Kidney Disease
Interventions:   Drug: Mesenchymal stem cell;   Procedure: Mesenchymal stem cell delivery with stent placement
Sponsors:   Mayo Clinic;   University of Mississippi Medical Center;   University of Alabama at Birmingham
Recruiting - verified June 2016

Hispanic Secondary Stroke Prevention Initiative

Condition:   Stroke
Interventions:   Behavioral: Community Health Worker (CHW) home visits, coaching phone calls, group sessions .;   Other: usual care and health education brochures every 4 months.
Sponsors:   University of Miami;   National Institute on Minority Health and Health Disparities (NIMHD)
Recruiting - verified June 2016

Pancreatic Stone Protein (PSP) in Pregnant Women

Conditions:   Pregnancy;   HELLP Syndrome;   Preterm Premature Rupture of Fetal Membranes;   Preeclampsia
Intervention:   Procedure: Blood collection
Sponsors:   Nicole Ochsenbein;   University of Zurich
Recruiting - verified June 2016

Pulmonary Arterial Denervation in Patients With Pulmonary Arterial Hypertension Associated With the Left Heart Failure

Condition:   Pulmonary Hypertension
Interventions:   Procedure: Pulmonary arterial denervation;   Drug: Standard treatment
Sponsor:   The First Affiliated Hospital with Nanjing Medical University
Recruiting - verified June 2016

Emergency Department Home Blood Pressure Monitoring and BpTRU Study

Condition:   Hypertension
Intervention:  
Sponsor:   Rhode Island Hospital
Recruiting - verified March 2016

Regorafenib as Single Agent in Patients With Metastatic Colorectal Cancer (mCRC) With Any RAS or BRAF Mutation Previously Treated With FOLFOXIRI Plus Bevacizumab

Conditions:   Colorectal Neoplasms;   Metastatic Disease
Intervention:   Drug: Regorafenib
Sponsors:   Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD);   Bayer
Recruiting - verified June 2016

Specified Drug Use-results Survey of Graceptor in Patients With Kidney Transplantation (Switching From Cyclosporine)

Condition:   the Maintenance Phase After Kidney Transplantation
Intervention:   Drug: Graceptor®
Sponsor:   Astellas Pharma Inc
Completed - verified May 2016

Treatment of Masked Hypertension

Conditions:   Masked Hypertension;   Hypertension;   Chronic Renal Insufficiency
Interventions:   Other: Antihypertensive medication intensification;   Other: Usual care
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Recruiting - verified June 2016

Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Recruiting - verified June 2016

Efficacy and Safety of Riociguat in Patients With Symptomatic Pulmonary Hypertension (PH) Associated With Idiopathic Interstitial Pneumonias (IIP)

Condition:   Idiopathic Interstitial Pneumonias / Hypertension,Pulmonary
Interventions:   Drug: Adempas, Riociguat (BAY63-2521);   Device: Placebo
Sponsor:   Bayer
Terminated - verified June 2016

Carnitine for the Treatment of Atherosclerosis.

Condition:   Metabolic Syndrome
Interventions:   Dietary Supplement: L-carnitine capsules;   Dietary Supplement: Cellulose capsules
Sponsors:   Queen's University;   Heart and Stroke Foundation of Canada
Recruiting - verified June 2016

Blood Pressure (BP) Visit Intensification Study

Conditions:   Blood Pressure;   Hypertension
Intervention:   Behavioral: JNC guideline training
Sponsor:   University of Rochester
Active, not recruiting - verified June 2016

EXPERT, EXPosurE Registry RiociguaT in Patients With Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat(BAY63-2521)
Sponsor:   Bayer
Recruiting - verified June 2016

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy;   Device: Carotid stenting
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified June 2016

Neural Mechanism of Aldosterone-induced Insulin Resistance

Condition:   Hypertension
Interventions:   Drug: DEFINITY® infusion;   Drug: Human Recombinant Regular Insulin infusion;   Drug: Dextrose infusion;   Procedure: Flow mediated vasodilation;   Procedure: Endothelial cell collection;   Procedure: Microvascular perfusion assessment using Definity;   Procedure: Microneurography
Sponsor:   University of Texas Southwestern Medical Center
Recruiting - verified June 2016

Renal Nerve Denervation in Patients With Hypertension and Paroxysmal and Persistent Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Hypertension
Interventions:   Drug: Renal nerve denervation;   Device: Cryoablation
Sponsor:   Medtronic Atrial Fibrillation Solutions
Recruiting - verified June 2016

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Conditions:   Hypertension;   Cardiovascular Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting - verified June 2016

Effects of Oral Sildenafil on Mortality in Adults With PAH

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: sildenafil citrate;   Drug: sildenafil citrate;   Drug: sildenafil citrate
Sponsor:   Pfizer
Recruiting - verified June 2016

Comparative PK PD Study in PAH Patients (Fox vs. I-Neb)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: lloprost(Ventavis,BAYQ6252, 20 µg/mL);   Drug: lloprost(Ventavis,BAYQ6252, 10 µg/mL)
Sponsor:   Bayer
Active, not recruiting - verified June 2016

Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude

Conditions:   Hypertension, Pulmonary;   Altitude Sickness
Intervention:   Drug: Riociguat
Sponsor:   Richard Moon
Completed - verified June 2016

Effect of Nebivolol on the Blood Flow in Hearts of Adults With High Blood Pressure and Abnormal Filling of Heart

Conditions:   Hypertension;   Left Ventricular Diastolic Dysfunction
Intervention:   Drug: Nebivolol
Sponsors:   Icahn School of Medicine at Mount Sinai;   Forest Laboratories
Completed - verified June 2016

Non-interventional Study on Compliance of Inhaled Treatment With Ventavis in Patient With Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Iloprost (Ventavis, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified June 2016

Sildenafil Therapy For Subjects Who Derive Clinical Benefit From Continued Treatment With Sildenafil

Condition:   Pulmonary Arterial Hypertension (PAH)
Intervention:   Drug: sildenafil
Sponsor:   Pfizer
Available - verified June 2016

Regorafenib in Frail and/or Unfit for Chemotherapy Patients With Metastatic Colorectal Cancer

Conditions:   Colorectal Neoplasms;   Metastatic Disease
Intervention:   Drug: Regorafenib
Sponsors:   Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD);   Bayer
Completed - verified June 2016

Self-Management in Stroke Survivors

Conditions:   Stroke;   Hypertension
Intervention:   Other: Self-Management / MTM using Health IT
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Berman Center for Outcomes and Clinical Research;   Agency for Healthcare Research and Quality (AHRQ)
Completed - verified June 2016

A Study of Tadalafil in Pediatric Participants With Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Interventions:   Drug: Tadalafil;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Recruiting - verified June 2016

Study on the Clinical Course Of Pulmonary Embolism

Conditions:   Cardiovascular Diseases;   Venous Thromboembolism;   Pulmonary Hypertension
Intervention:  
Sponsor:   University of Padua
Completed - verified June 2016

DO-HEALTH / Vitamin D3 - Omega3 - Home Exercise - Healthy Ageing and Longevity Trial

Condition:   Improve Healthy Ageing in Seniors; Prevent Disease at Older Age
Interventions:   Drug: Vitamin D3;   Drug: Omega 3 fatty acids;   Procedure: Strength Home Exercise;   Procedure: Flexibility Home Exercise
Sponsors:   University of Zurich;   Recruitment Partners;   University of Geneva, Switzerland;   University of Basel;   University Hospital, Toulouse, France (Prof. Bruno Vellas, MD);   Charite University, Berlin, Germany;   Medical University Innsbruck;   University of Coimbra, Portugal (Prof. José daSilva, MD);   Other University Partners;   University of Sheffield;   University of Manchester, UK (Prof. David Felson, MD MPH);   Max Rubner University, Germany (Prof. Bernhard Watzl, PhD);   Technische Universität Dresden;   Impact Partner;   International Osteoporosis Foundation (IOF; Prof. John Kanis, MD);   SME Partners;   Ferrari Data Solutions GmBH, Switzerland (Stephen M. Ferrari; direct data entry platform);   Gut Pictures, Switzerland (Benno Gut; animated exercise video);   NOVAMEN, France (Sandrine Rival; logistic management partner);   Pharmalys, UK (Marieme Ba; monitoring partner);   Industry Partners;   DSM Nutritional Products (Dr. Elisabeth Stöcklin PhD, Dr. Manfred Eggersdorfer PhD);   Nestlé (Michaela Höhne PhD, Irène Corthesy PhD);   Roche-Diagnostics (Monika Reuschling);   Funding within Framework 7 research program of the European Commission (project 278588);   Further collaborators and advisors at website do-health.eu
Active, not recruiting - verified June 2016

Ambrisentan for Treatment of Portopulmonary Hypertension

Condition:   Portopulmonary Hypertension
Intervention:   Drug: ambrisentan
Sponsor:   Medical University of Graz
Withdrawn - verified June 2016

Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers

Conditions:   Pre-eclampsia;   Intra-uterine Growth Restriction
Interventions:   Drug: Aspirin;   Drug: Placebo
Sponsor:   University Hospital, Tours
Active, not recruiting - verified June 2016

Effect of Acupuncture on Patients With Mild Hypertension

Condition:   Essential Hypertension
Interventions:   Other: acupuncture;   Other: Sham acupuncture
Sponsors:   Chengdu University of Traditional Chinese Medicine;   Hunan University of Traditional Chinese Medicine
Completed - verified June 2016

DETECT and Retinal Outcomes in Hypertension

Conditions:   Hypertension;   Retinal Disorder;   Cognitive Impairment
Intervention:  
Sponsor:   Emory University
Recruiting - verified June 2016

Tailored Approaches to Improve Medication Adherence

Condition:   Hypertension
Intervention:   Behavioral: Adherence Intervention
Sponsors:   New York University School of Medicine;   American Heart Association
Recruiting - verified June 2016

Consequences of Antiangiogenic Factors Involved in Preeclampsia on Intra-uterine Growth Restricted Preterm Newborn

Conditions:   Preterm Birth;   Intra-uterine Growth Restriction;   Maternal Preeclampsia;   Bronchopulmonary Dysplasia
Intervention:   Other: Biological samples
Sponsor:   Assistance Publique - Hôpitaux de Paris
Completed - verified June 2016

Vitamin D and Preeclampsia

Conditions:   Vitamin D Deficiency Defined as Serum 25OHD < 75 Nmol/l or 30ng/ml;   Preeclampsia;   Neonatal Hypercalcemia;   Pregnancy
Intervention:  
Sponsor:   Assistance Publique - Hôpitaux de Paris
Active, not recruiting - verified June 2016

Safety And Efficacy Of Sildenafil In Children With Pulmonary Arterial Hypertension

Conditions:   Pulmonary Arterial Hypertension;   Hypertension, Pulmonary
Intervention:   Drug: Sildenafil
Sponsor:   Pfizer
Recruiting - verified June 2016

Randomized, Double-Blind, Safety and Efficacy Study of RE-021 (Sparsentan) in Focal Segmental Glomerulosclerosis

Condition:   Focal Segmental Glomerulosclerosis
Interventions:   Drug: RE-021 (Sparsentan);   Drug: Irbesartan
Sponsor:   Retrophin, Inc.
Active, not recruiting - verified April 2016

Pravastatin for Prevention of Preeclampsia

Condition:   Preeclampsia
Interventions:   Drug: Pravastatin;   Drug: Placebo
Sponsors:   The University of Texas Medical Branch, Galveston;   University of Texas;   University of Pittsburgh;   Northwestern University
Recruiting - verified June 2016

A Pharmacokinetics Study for Pediatric Participants With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Tadalafil- Tablet
Sponsor:   Eli Lilly and Company
Recruiting - verified June 2016

Gestational Diabetes Mellitus and Cardiometabolic Syndrome in Offspring

Condition:   Gestational Diabetes Mellitus
Intervention:  
Sponsors:   Université de Sherbrooke;   Eli Lilly and Company
Completed - verified June 2016

IV Iron Replacement for Iron Deficiency in Idiopathic Pulmonary Arterial Hypertension (IPAH) Patients

Conditions:   Pulmonary Arterial Hypertension;   Iron Deficiency
Interventions:   Drug: Saline;   Drug: Ferinject or CosmoFer
Sponsors:   Imperial College London;   Fu Wai Hospital, Beijing, China
Recruiting - verified June 2016

Inhaled Iloprost in the Treatment of Patients With Pulmonary Hypertension up to 4 Years

Condition:   Pulmonary Hypertension
Intervention:   Drug: Ventavis inhaled (Iloprost, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified June 2016

Hyperpolarized 129Xe MRI for Imaging Pulmonary Function

Conditions:   Asthma;   Chronic Obstructive Pulmonary Disease;   Interstitial Lung Disease;   Cystic Fibrosis;   Pulmonary Hypertension
Intervention:   Drug: Xenon
Sponsor:   Bastiaan Driehuys
Recruiting - verified June 2016

Early Primary Prophylaxis of Esophageal Varices

Condition:   Cirrhosis
Interventions:   Drug: Carvedilol;   Drug: Placebo
Sponsor:   Institute of Liver and Biliary Sciences, India
Completed - verified December 2013

Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, Mali

Condition:   Malaria
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified June 2016

Non Invasive Study of the Hepatic Fibrosis in Paediatrics by the Method of Study of Pediatric Hepatic Fibrosis

Conditions:   Cirrhosis;   Liver Fibrosis;   Portal Hypertension;   Cystic Fibrosis;   Cholestasis of Parenteral Nutrition
Intervention:   Other: Elastometry
Sponsor:   Assistance Publique - Hôpitaux de Paris
Active, not recruiting - verified June 2016

Serum Lipid Levels and Other Biomarkers of Cardiovascular Disease in Patients With Psoriasis

Conditions:   Psoriasis;   Cardiovascular Diseases;   Dyslipidemia
Intervention:  
Sponsor:   George Washington University
Completed - verified February 2016

Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science

Condition:   Congenital Diaphragmatic Hernia
Intervention:  
Sponsors:   Columbia University;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified June 2016

A Case Control Study Evaluating the Prevalence of Non-Alcoholic Fatty Liver Disease Among Patients With Psoriasis

Conditions:   Psoriasis;   Nonalcoholic Fatty Liver Disease
Intervention:  
Sponsor:   George Washington University
Completed - verified February 2016

Cardiovascular Disease Study

Condition:   Spinal Cord Injury
Interventions:   Procedure: 2 hour Oral Glucose Tolerance Test;   Procedure: Fat Meal Test
Sponsors:   VA Office of Research and Development;   Kessler Foundation
Recruiting - verified June 2016

Long Term Treatment of End Stage Renal Disease Patients With Lanthanum Carbonate (Fosrenol)

Condition:   Hyperphosphatemia
Intervention:  
Sponsor:   Shire
Completed - verified June 2016

Preventing Microalbuminuria in Type 2 Diabetes

Condition:   Diabetes
Interventions:   Drug: Benazepril;   Drug: Valsartan;   Drug: Benazepril/Valsartan
Sponsors:   Mario Negri Institute for Pharmacological Research;   Agenzia Italiana del Farmaco
Active, not recruiting - verified June 2016

Clinical and Economic Benefits of Cardiovascular Risk Management by a Dietician in Type 2 Diabetes Patients

Conditions:   Type 1 Diabetes;   Type 2 Diabetes
Interventions:   Behavioral: Intensive treatment;   Other: Normal follow-up
Sponsors:   Université de Sherbrooke;   Pfizer
Active, not recruiting - verified June 2016

Interactive Multirisk-Factor Intervention for Hypertension (HTN) Blacks

Condition:   Hypertension
Interventions:   Behavioral: Automated Telephone Program;   Behavioral: Health Behavior Education
Sponsor:   Boston Medical Center
Completed - verified June 2016

20 Year Changes in Fitness & Cardiovascular Disease Risk - Ancillary to CARDIA

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Diabetes Mellitus;   Metabolic Syndrome X;   Hypertension;   Obesity
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified November 2008

Genetics of Hypertension in Blacks

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified December 2008

Metabolic Differences of Overweight Children and Children of Overweight Parents

Condition:   Obesity
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting - verified June 2016