High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

LEPU Renal Denervation System for Resistant Hypertension

Conditions:   Hypertension;   Cardiovascular Diseases;   Vascular Diseases
Intervention:   Device: LEPU Renal Denervation System
Sponsors:   Lepu Medical Technology (Beijing) Co.,Ltd;   Cardiovascular Institute & Fuwai Hospital
Completed - verified August 2015

The Effect of Pre-discharge Blood Pressure of Patients With Asymptomatic Severe Hypertension in Emergency Department

Conditions:   Hypertension;   Emergencies;   Asymptomatic Conditions
Intervention:   Drug: Antihypertensive meds
Sponsor:   Chulalongkorn University
Recruiting - verified September 2015

An Open-label Extension Study to Evaluate the Safety of the 13 mg Bimatoprost Ocular Insert

Conditions:   Primary Open-Angle Glaucoma;   Ocular Hypertension
Intervention:   Drug: Bimatoprost Ocular Insert
Sponsor:   ForSight Vision5, Inc.
Enrolling by invitation - verified August 2015

Comparison of Telemedical and Conventional Treatment of Hypertension

Condition:   Hypertension
Interventions:   Behavioral: Telemedical home blood pressure measurements;   Behavioral: Conventional blood pressure monitoring
Sponsor:   Erling Bjerregaard Pedersen
Completed - verified August 2015

28-Day Repeated Topical Study to Evaluate the Safety and Activity of 5 Escalating Dose Levels of SAR366234 and One Dose of Latanoprost in Patients With Open Angle Glaucoma or Ocular Hypertension

Condition:   Open Angle Glaucoma -Ocular Hypertension
Interventions:   Drug: SAR366234;   Drug: latanoprost
Sponsor:   Sanofi
Recruiting - verified August 2015

Acupuncture as a Complementary Treatment for Hypertension (ACT-HAS)

Condition:   Hypertensive Disease
Intervention:   Other: Laser acupuncture
Sponsors:   Universidade Federal do Rio de Janeiro;   Ministry of Health, Brazil;   Conselho Nacional de Desenvolvimento Científico e Tecnológico
Recruiting - verified August 2015

Multi-micronutrient Supplementation During Peri-conception and Congenital Heart Disease

Condition:   Congenital Heart Disease
Interventions:   Dietary Supplement: Vitamin B Complex and Folic Acid;   Dietary Supplement: Iron and Folic Acid;   Dietary Supplement: Folic Acid
Sponsor:   Xi’an Jiaotong University College of Medicine
Not yet recruiting - verified September 2015

Comparison of Covered and Bare Stent in TIPS

Condition:   Cirrhosis
Interventions:   Device: covered stent;   Device: bare stent
Sponsor:   Beijing Shijitan Hospital
Completed - verified September 2015

Evaluation of South Africa's National Adherence Strategy

Condition:   HIV
Intervention:   Behavioral: Minimum package of interventions to improve ART adherence
Sponsors:   Boston University;   World Bank
Not yet recruiting - verified August 2015

Electronic Activity Level Monitoring Pilot in Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Hypertension, Pulmonary
Intervention:   Other: Correlation  assessment
Sponsor:   Bayer
Recruiting - verified August 2015

Anti-hypertensive Effect of Mycelia of Antrodia Cinnamomea

Condition:   Hypertension
Interventions:   Dietary Supplement: AC mycelia;   Dietary Supplement: Placebo
Sponsor:   Chung Shan Medical University
Completed - verified August 2015

Central and Peripheral Blood Pressure in Stroke

Conditions:   Stroke, Acute;   Blood Pressure
Intervention:   Other: Blood pressure assessment
Sponsors:   Hampshire Hospitals NHS Foundation Trust;   The University of Winchester
Not yet recruiting - verified September 2015

Non-invasive Evaluation of Myocardial Stiffness by Elastography

Condition:   Diastolic Heart Failure
Interventions:   Procedure: elastography function ShearWave Imaging;   Procedure: MRI
Sponsors:   French Cardiology Society;   Institut National de la Santé Et de la Recherche Médicale, France
Not yet recruiting - verified August 2015

Intestinal Phosphate Transporter Expression in CKD Patients

Condition:   Chronic Kidney Diseases
Intervention:   Procedure: endoscopy
Sponsors:   RWTH Aachen University;   Chugai Pharmaceutical
Not yet recruiting - verified August 2015

Early Vascular Adjustments During Hypertensive Pregnancy

Conditions:   Hypertension, Pregnancy-Induced;   Pre-Eclampsia
Interventions:   Drug: Labetalol;   Drug: Nifedipine;   Drug: Methyldopa
Sponsor:   Maastricht University Medical Center
Not yet recruiting - verified August 2015

The Effect of Blood Pressure on Cerebral Perfusion During Vascular Surgery

Conditions:   Anesthesia;   Peripheral Arterial Diseases
Interventions:   Other: MAP maintained at 80 mmHg;   Other: MAP maintained at 60 mmHg
Sponsor:   Rigshospitalet, Denmark
Recruiting - verified August 2015

Renal Artery Stenting in Patients With Documented Resistant Hypertension and Atherosclerotic Renal Artery Stenosis (ANDORRA)

Conditions:   Hypertension;   Hypertension Resistant to Conventional Therapy;   Angiographically Proven Grade III Unilateral or Bilateral Atherosclerotic Renal Artery Stenosis (ARAS) ≥ 60%
Interventions:   Device: Renal artery Angioplasty plus stenting.;   Drug: Anti hypertensive, statin and antiplatelet medication.
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Ministry of Health, France
Not yet recruiting - verified July 2015

Trial of Hemospray Plus Epinephrine Injection Versus Endoscopic Hemoclip

Condition:   Upper Gastrointestinal Bleeding
Interventions:   Device: Metal clips;   Drug: Hemospray;   Procedure: Endoscopy Exam;   Drug: Adrenaline
Sponsor:   University of Sao Paulo General Hospital
Not yet recruiting - verified July 2015

The Effect of Ocular Massage on the Management of Elevated Intraocular Pressure After Acute Angle Closure

Condition:   Intraocular Pressure
Interventions:   Other: ocular massage;   Device: LenstarLS900;   Device: Goldmann tonometer
Sponsor:   Lv Yingjuan
Completed - verified August 2015

Evaluation of the Heparin Binding Protein Levels in Sepsis

Conditions:   Sepsis;   Infection;   Septic Shock
Intervention:   Other: HBP lab test
Sponsor:   Christiana Care Health Services
Recruiting - verified August 2015

Associations of Vitamin D Deficiency and Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma

Conditions:   Vitamin D Deficiency;   Primary Open- Angle Glaucoma
Interventions:   Other: Vitamin D receptor polymorphic analysis;   Other: Serum levels of 1a, 25-Dihydroxyvitamin D3
Sponsor:   Lv Yingjuan
Completed - verified August 2015

Fimasartan Achieving SBP Target (FAST) Study

Condition:   Essential,Hypertension
Interventions:   Drug: Placebo;   Drug: Fimasartan;   Drug: Valsartan;   Drug: Olmesartan medoxomil
Sponsor:   Boryung Pharmaceutical Co., Ltd
Recruiting - verified August 2015

Azilsartan Medoxomil in the Treatment of Essential Hypertension and Type 2 Diabetes in Asia

Conditions:   Essential Hypertension;   Type 2 Diabetes Mellitus
Intervention:   Drug: Azilsartan Medoxomil
Sponsor:   Takeda
Recruiting - verified August 2015

Clinical Trial to Evaluation the Safety and Efficacy of GR-MD-02 for the Treatment of Liver Fibrosis and Resultant Portal Hypertension in Patients With Nash Cirrhosis

Condition:   Hypertension, Portal
Intervention:   Drug: GR-MD-02
Sponsors:   Galectin Therapeutics Inc.;   Stephen A. Harrison, MD, Brooke Army Medical Center;   Naga Chalasani, MD, Indiana University
Recruiting - verified June 2015

Effects of Electroacupuncture on Stress Response During Extubation of General Anesthesia in Elderly Patients

Condition:   Stress
Intervention:   Device: electro-acupuncture
Sponsor:   Shengjing Hospital
Recruiting - verified August 2015

Analysis of CRBSI Rates in Patients With a NexSite™ HD (Hemodialysis) Catheter

Condition:   End Stage Renal Disease
Intervention:   Device: NexSite HD Patients
Sponsor:   Marvao Medical
Recruiting - verified September 2015

Study Comparing Lutonix AV Drug Coated Balloon vs Standard Balloon for Treatment of Dysfunctional AV Fistulae

Condition:   Arteriovenous Fistula
Interventions:   Device: Lutonix DCB;   Device: Standard Balloon Angioplasty Catheter
Sponsor:   C. R. Bard
Recruiting - verified August 2015

Sepsis Assessment in Belgian Emergency Rooms

Conditions:   Sepsis;   Shock, Septic;   Severe Sepsis
Intervention:  
Sponsor:   Axis Shield Diagnostics Ltd
Recruiting - verified September 2015

Economic Evaluation of Baroreceptor STIMulation for the Treatment of Resistant HyperTensioN

Condition:   Hypertension
Intervention:   Device: Baroreceptor stimulation with Barostim Neo TM
Sponsor:   Central Hospital, Nancy, France
Recruiting - verified August 2015

Check and Support -Enhancing the Treatment of Hypertension in Outpatient Care, a Multicenter Study

Conditions:   Hypertension;   Blood Pressure;   Patient Compliance;   Patient Adherence;   Medication Adherence
Interventions:   Behavioral: IMB model-based initiation of antihypertensive medication;   Behavioral: Tailored SMS-text message support;   Behavioral: Usual care
Sponsors:   Kuopio University Hospital;   Health Centre of Jyväskylä Cooperation Area;   Central Finland Hospital District;   Occupational Health Care Työterveys Aalto;   Mehiläinen Jyväskylä Occupational health services;   Northern Savo Hospital District
Recruiting - verified September 2015

DVA Risk Pregnancy

Conditions:   Pregnancy;   High Risk Pregnancies
Interventions:   Other: Obstetrical care parameters;   Other: DVA measurements;   Other: Fundus photographs
Sponsor:   Medical University of Vienna
Recruiting - verified August 2015

Natural History and Biology of Long-Term Late Effects Following Hematopoietic Cell Transplant for Childhood Hematologic Malignancies

Conditions:   Acute Lymphoblastic Leukemia/Lymphoma;   Myelodysplasia;   Acute Myelogenous Leukemia;   Juvenile Myelomonocytic Leukemia;   Chronic Myelogenous Leukemia
Intervention:  
Sponsors:   Center for International Blood and Marrow Transplant Research;   Pediatric Blood and Marrow Transplant Consortium;   National Marrow Donor Program
Recruiting - verified August 2015

Endothelial Microparticles in Systemic Sclerosis Pulmonary Hypertension

Conditions:   Systemic Sclerosis;   Pulmonary Hypertension;   Scleroderma
Intervention:   Other: No intervention given
Sponsors:   Louisiana State University Health Sciences Center in New Orleans;   University of South Alabama
Recruiting - verified August 2015

Determine the Safety/Efficacy of Ticagrelor for Maintaining Patency of Arterio-Venous Fistulae Created for Hemodialysis

Conditions:   End Stage Renal Disease;   Vascular Access Patency
Interventions:   Drug: ticagrelor;   Drug: Placebo
Sponsors:   University of Virginia;   AstraZeneca
Recruiting - verified August 2015

Improving Mental Health Through Integration With Primary Care in Rural Karnataka

Conditions:   Chronic Disease;   Depression;   Anxiety
Intervention:   Behavioral: Healthy Living Intervention
Sponsors:   University of California, San Francisco;   National Institute of Mental Health (NIMH)
Recruiting - verified August 2015

Renal Sympathetic Denervation by Iberis System in Patients With Uncontrolled Hypertension - Iberis-HTN Registry

Condition:   Resistant Hypertension
Intervention:   Device: Renal Denervation
Sponsor:   Terumo Europe N.V.
Recruiting - verified September 2015

Online CBT-I for High Blood Pressure

Conditions:   Hypertension;   Prehypertension;   Insomnia
Interventions:   Behavioral: Cognitive Behavioral Therapy;   Behavioral: Healthy Sleep Habits
Sponsors:   Emory University;   American Heart Association
Recruiting - verified August 2015

Effect of L-Arginine and Pycnogenol on Light to Moderate Hypertension and Endothelial Function

Conditions:   Hyperhomocysteinemia;   Hypertension Grade I
Intervention:   Dietary Supplement: Verum
Sponsors:   Dr. Loges & Co. GmbH;   BioTeSys GmbH
Completed - verified August 2015

Comparison of Effects Between Amlodipine and Hydrochlorothiazide in Combination With Losartan on 24-hr Central Blood Pressure in Hypertensive Patients

Condition:   Hypertension
Interventions:   Drug: Losartan 50mg/amlodipine 5mg;   Drug: Losartan 100mg/amlodipine 5mg;   Drug: Losartan 50mg/Hydrochlorothiazide 12.5mg;   Drug: Losartan 100mg/Hydrochlorothiazide 25mg
Sponsor:   Chong-Jin Kim
Recruiting - verified September 2015

Anesthetic Premedication With a Cannabis Extract (Cannapremed)

Conditions:   Pain, Postoperative;   Postoperative Nausea and Vomiting;   Anxiety
Interventions:   Drug: Tetrahydrocannabinol;   Drug: Acetaminophen;   Drug: Midazolam;   Drug: Placebo (for nabiximols)
Sponsors:   Hadassah Medical Organization;   GW Pharmaceuticals Ltd.
Recruiting - verified August 2015

Safety, Tolerability, and Pharmacokinetics of Oral Treprostinil in Pediatric PAH Patients Aged 7 to 17 Years

Condition:   PAH
Intervention:   Drug: oral treprostinil
Sponsor:   United Therapeutics
Recruiting - verified September 2015

An Efficacy and Safety Study in Children 6 to Less Than 18 Years of Age With Hypertension

Condition:   Hypertension
Interventions:   Drug: Azilsartan Medoxomil;   Drug: Losartan;   Drug: Placebo for Azilsartan Medoxomil;   Drug: Placebo for Losartan
Sponsor:   Arbor Pharmaceuticals, Inc.
Recruiting - verified August 2015

GS-4997 in Adults With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: GS-4997;   Drug: Placebo to match GS-4997
Sponsor:   Gilead Sciences
Recruiting - verified September 2015

The optImal Hydration With sodiuM chloridE in High Risk Patients Undergoing Coronary Angiography

Condition:   Chronic Kidney Disease
Interventions:   Other: Long Hydration;   Other: Short Hydration
Sponsors:   Guangdong General Hospital;   Peking University First Hospital;   Fudan University
Recruiting - verified August 2015

Pulmonary Arterial Denervation in Patients With Pulmonary Arterial Hypertension Associated With the Left Heart Failure

Condition:   Pulmonary Hypertension
Interventions:   Procedure: Pulmonary arterial denervation;   Drug: Standard treatment
Sponsor:   The First Hospital of Nanjing Medical University
Recruiting - verified September 2015

ESTEEM - Effect of Simple, Targeted Diet in Pregnant Women With Metabolic Risk Factors on Pre-eclampsia

Conditions:   Pre-eclampsia;   Obesity;   Raised Lipids;   High Blood Pressure;   Insulin Resistance
Interventions:   Behavioral: Targeted ESTEEM diet;   Other: Non-randomised cohort
Sponsor:   Queen Mary University of London
Recruiting - verified May 2014

Different Dosages of Bioactive Wheat Peptides and Blood Pressure Level and CVD Risk Biomarkers in Healthy Subjects

Condition:   Pre-hypertension
Interventions:   Other: Comparisons of two kind of pasta with low or high content of wheat bioactive peptides (sequence Low->High);   Other: Comparisons of two kind of pasta with low or high content of wheat bioactive peptides (sequence High->Low)
Sponsors:   University of Bologna;   EU
Recruiting - verified August 2015

Telehealth Self-Management Program in Older Adults Living With Heart Failure in Health Disparity Communities

Condition:   Chronic Heart Failure
Interventions:   Device: Telehealth Self Management (TSM);   Other: Standard of Care
Sponsor:   North Shore Long Island Jewish Health System
Recruiting - verified August 2015

24 Week Efficacy and Safety Study of Empagliflozin (BI 10773) in Hypertensive Black/African American Patients With Type 2 Diabetes Mellitus and Hypertension

Conditions:   Diabetes Mellitus, Type 2;   Hypertension
Interventions:   Drug: Empagliflizon low dose;   Drug: placebo;   Drug: Empagliflizon high dose
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified September 2015

MOTION, Measuring Outcomes in Treatment Naive Patients

Condition:   Pulmonary
Intervention:   Drug: Riociguat (Adempas,BAY63-2521)
Sponsor:   Bayer
Recruiting - verified August 2015

Azilsartan/Amlodipine Combination Tablets LD & HD Specified Drug-use Survey "Long-term Use Survey"

Condition:   Hypertension
Intervention:   Drug: Azilsartan/amlodipine
Sponsor:   Takeda
Recruiting - verified August 2015

Study to Evaluate the Effect of Celecoxib on the Efficacy and Safety of Amlodipine in Subjects With Hypertension Requiring Antihypertensive Therapy

Condition:   Hypertension
Interventions:   Drug: Over-encapsulated 10 mg amlodipine besylate tablet;   Drug: Matched placebo capsule for over-encapsulated celecoxib capsule;   Drug: Over-encapsulated 200 mg celecoxib capsule;   Drug: Matched placebo tablet for over-encapsulated amlodipine besylate tablet
Sponsor:   Kitov Pharmaceuticals, Ltd.
Recruiting - verified August 2015

Efficacy, Safety, and Tolerability of GS-4997 in Participants With Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: GS-4997;   Drug: Placebo to match GS-4997
Sponsor:   Gilead Sciences
Active, not recruiting - verified August 2015

Diuretics for Postpartum High Blood Pressure in Preeclampsia

Condition:   Preeclampsia
Interventions:   Drug: FUROSEMIDE;   Drug: Placebo
Sponsor:   Instituto Materno Infantil Prof. Fernando Figueira
Completed - verified August 2015

Comparative Effectiveness of Ambulatory Blood Pressure Monitoring vs Usual Care for Diagnosing and Managing Hypertension: A Pilot Study

Condition:   Hypertension
Interventions:   Drug: Amlodipine;   Drug: Chlorthalidone;   Drug: Losartan
Sponsors:   Anthony J Viera, MD, MPH;   North Carolina Translational and Clinical Sciences Institute
Active, not recruiting - verified September 2015

A Study to Evaluate Pharmacokinetics of Tafluprost Ophthalmic Solution (0.0015%) in Pediatric Patients With Glaucoma or Ocular Hypertension

Conditions:   Glaucoma;   Ocular Hypertension
Intervention:   Drug: Preservative free tafluprost opthalmic solution
Sponsor:   Santen Oy
Active, not recruiting - verified September 2015

Microvascular Function in Primary Aldosteronism

Conditions:   Primary Aldosteronism;   Essential Hypertension
Interventions:   Procedure: Adrenal extirpation;   Drug: Antihypertensive medication
Sponsor:   Maastricht University Medical Center
Withdrawn - verified August 2015

Efficacy and Safety Study of OPC-1085EL Ophthalmic Solution in Subjects With Glaucoma or Ocular Hypertension

Conditions:   Glaucoma;   Ocular Hypertension
Interventions:   Drug: OPC-1085EL ophthalmic solution;   Drug: Carteolol long-acting ophthalmic solution
Sponsor:   Otsuka Pharmaceutical Co., Ltd.
Completed - verified August 2015

Efficacy and Safety Study of OPC-1085EL Ophthalmic Solution in Subjects With Glaucoma or Ocular Hypertension

Conditions:   Glaucoma;   Ocular Hypertension
Interventions:   Drug: OPC-1085EL ophthalmic solution;   Drug: Latanoprost ophthalmic solution
Sponsor:   Otsuka Pharmaceutical Co., Ltd.
Completed - verified August 2015

A Phase 2 Extension Study of Study GCS-100-CS-4002

Condition:   Chronic Kidney Disease
Intervention:   Drug: GCS-100
Sponsor:   La Jolla Pharmaceutical Company
Active, not recruiting - verified August 2015

Phenylephrine Dose and Mode of Administration for Spinal Anesthesia Induced Hypotension

Conditions:   Complications; Cesarean Section;   Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Intervention:   Drug: Phenylephrine
Sponsor:   Wake Forest School of Medicine 
Enrolling by invitation - verified August 2015

Blood Pressure, Cerebral Blood Flow and Cognition in Spinal Cord Injury

Condition:   Spinal Cord Injury
Interventions:   Drug: Midodrine;   Drug: Placebo
Sponsors:   James J. Peters Veterans Affairs Medical Center;   Kessler Foundation
Recruiting - verified August 2015

A Study to Explore the Effects of Azilsartan Compared to Telmisartan on Insulin Resistance of Patients With Essential Hypertension on Type 2 Diabetes Mellitus by HOMA-R

Condition:   Essential Hypertension Complicated by Type 2 Diabetes Mellitus
Interventions:   Drug: Azilsartan;   Drug: Telmisartan
Sponsor:   Takeda
Recruiting - verified August 2015

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Conditions:   Hypertension;   Cardiovascular Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting - verified August 2015

Bardoxolone Methyl Evaluation in Patients With Pulmonary Arterial Hypertension (PAH) - LARIAT

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Bardoxolone methyl;   Drug: Placebo
Sponsor:   Reata Pharmaceuticals, Inc.
Recruiting - verified August 2015

Understanding the Exercise-Hypertension Paradox

Condition:   Hypertension
Interventions:   Dietary Supplement: Oral Antioxidant;   Other: Exercise rehabilitation
Sponsor:   Department of Veterans Affairs
Recruiting - verified August 2015

Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women

Conditions:   Menopause;   Aging
Interventions:   Drug: KUVAN;   Drug: Placebo;   Drug: Cetrotide;   Drug: Climara;   Drug: Placebo transdermal patch
Sponsors:   University of Colorado, Denver;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified August 2015

MERIT-2: Macitentan in thE tReatment of Inoperable Chronic Thromboembolic Pulmonary Hypertension (OL)

Condition:   Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Recruiting - verified August 2015

Comparison of Latanoprost PPDS With Timolol Maleate GFS in Subjects With Ocular Hypertension or Open-Angle Glaucoma

Conditions:   Ocular Hypertension;   Open-Angle Glaucoma
Intervention:   Drug: Latanoprost Punctal Plug Delivery System (L-PPDS)
Sponsor:   Mati Therapeutics Inc.
Recruiting - verified June 2015

Efficacy of fimaSartan on arTerIal stiFFness iN patiEntS With HypertenSion

Condition:   Hypertension
Intervention:   Drug: Fimasartan
Sponsor:   Boryung Pharmaceutical Co., Ltd
Recruiting - verified August 2015

Rifaximin vs Placebo for the Prevention of Encephalopathy in Patients Treated by TIPS

Condition:   Cirrhosis
Interventions:   Drug: Rifaximin;   Drug: placebo
Sponsor:   University Hospital, Toulouse
Recruiting - verified August 2015

Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health in Spinal Cord Injury

Condition:   Spinal Cord Injury
Intervention:  
Sponsors:   James J. Peters Veterans Affairs Medical Center;   Kessler Foundation
Recruiting - verified August 2015

A Study of Muscle Strength Maintenance in Older Adults

Condition:   Sarcopenia
Interventions:   Drug: Losartan;   Drug: Placebo
Sponsors:   Johns Hopkins University;   National Institutes of Health (NIH);   National Institute on Aging (NIA)
Recruiting - verified August 2015

Treatment of Pain and Autonomic Dysreflexia in Spinal Cord Injury With Deep Brain Stimulation

Conditions:   Pain;   Autonomic Dysreflexia
Intervention:   Device: Deep Brain Stimulation
Sponsors:   Jonathan Jagid;   Department of Defense
Recruiting - verified August 2015

Blood Flow Regulation in Glaucoma

Condition:   Glaucoma
Intervention:   Other: Isometric exercise
Sponsor:   Medical University of Vienna
Recruiting - verified August 2015

The Hypotensive Effect of Metformin in Hypertensive Patients.

Condition:   Hypertension
Interventions:   Drug: Metformin;   Drug: Placebo
Sponsor:   Hospital de Clinicas de Porto Alegre
Recruiting - verified August 2015

GLORIA-AF Registry Program (Phase II/III)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2015

Improving Hypertension Control

Condition:   Hypertension
Intervention:   Behavioral: Lifestyle counseling
Sponsors:   Medical College of Wisconsin;   Progressive Community Health Center
Completed - verified August 2015

Non-interventional Multi-center Study on Patients Under Routine Treatment of Pulmonary Arterial Hypertension (PAH) With Inhaled Iloprost Using I-Neb as a Device for Inhalation

Condition:   Pulmonary Hypertension
Intervention:   Drug: Ventavis (Iloprost, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified August 2015

Community Level Interventions for Pre-eclampsia

Conditions:   Pre-eclampsia;   Hypertension, Pregnancy Induced
Interventions:   Behavioral: Community Engagement;   Device: PIERS on the Move mHealth decision aid;   Drug: Magnesium Sulfate;   Drug: Methyldopa
Sponsors:   University of British Columbia;   Bill and Melinda Gates Foundation;   Olabisi Onabanjo University;   Centro de Investigacao em Saude de Manhica;   Aga Khan University;   Jawaharlal Nehru Medical College
Recruiting - verified August 2015

Ambrisentan for Inoperable Chronic Thromboembolic Pulmonary Hypertension.

Condition:   Hypertension
Interventions:   Drug: Ambrisentan 5 mg;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Completed - verified August 2015

Cardiovascular, Cerebrovascular, and Cognitive Function in Spinal Cord Injury

Condition:   Spinal Cord Injury
Intervention:  
Sponsor:   James J. Peters Veterans Affairs Medical Center
Recruiting - verified August 2015

Evaluation of Portal Venous System Thrombosis After Blunt Splenic Trauma Utilizing Doppler Ultrasound

Condition:   Thrombosis of Portal Venous System.
Intervention:   Other: Doppler Ultrasound
Sponsor:   Rambam Health Care Campus
Recruiting - verified August 2015

Effect of Methyldopa on MHC Class II Antigen Presentation in Type 1 Diabetes

Condition:   Diabetes Mellitus, Type 1
Intervention:   Drug: Methyldopa
Sponsors:   University of Colorado Denver School of Medicine Barbara Davis Center;   Juvenile Diabetes Research Foundation
Recruiting - verified August 2015

A Pilot Study of Pre- and Post-operative Use of Somatuline Depot.

Condition:   Acromegaly
Intervention:   Drug: lanreotide
Sponsor:   John Wayne Cancer Institute
Recruiting - verified September 2015

IMproved PRegnancy Outcome by Early Detection

Conditions:   Pre-eclampsia;   Pregnancy;   Pregnancy, High-risk;   Pregnancy Complications
Intervention:  
Sponsors:   Louise Kenny;   Keele University, UK;   University of Liverpool, UK;   Karolinska University, Stockholm, Sweden;   Erasmus University Medical Centre Rotterdam, The Netherlands;   University of Cologne, Germany;   the Copenhagen Trial Unit, Centre for Clinical Intervention Research, Denmark;   MedSciNet AB, Stockholm, Sweden;   MyCartis, Ghent, Belgium;   Metabolomic Diagnostics Ltd, Cork, Ireland;   Accelopment,Zürich, Switzerland
Recruiting - verified August 2015

OneShot Renal Denervation Registry

Conditions:   Hypertension;   Heart Failure;   Diabetes Mellitus;   Sleep Apnea
Intervention:   Device: OneShot Ablation System
Sponsor:   Medtronic Endovascular
Terminated - verified August 2015

Calcium Supplementation to Prevent Preeclampsia in Sichuan Province of China

Condition:   Preeclampsia
Intervention:   Drug: calcium
Sponsors:   West China Second University Hospital;   Sichuan Academy of Medical Sciences;   people's hospital of Guang'an;   pengzhou shi fuyou baojianyuan;   The first people's hospital of Neijiang;   Suining Central Hospital;   Sichuan Provincial Maternal and Child Health Care Hospital;   Chengdu Women's and Children's Central Hospital
Recruiting - verified April 2014

Prediction of Adverse Perinatal Outcome for Preeclampsia in Sichuan Province of China

Condition:   Preeclampsia
Intervention:  
Sponsors:   West China Second University Hospital;   Sichuan Academy of Medical Sciences;   people's hospital of Guang'an;   The first people's hospital of Neijiang;   Suining Central Hospital;   Sichuan Provincial Maternal and Child Health Care Hospital;   Chengdu Women's and Children's Central Hospital;   Luzhou Medical College;   pengzhou shi fuyou baojianyuan;   NANCHONG CENTRAL HOSPITAL
Not yet recruiting - verified June 2013

Riociguat in Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Adempas (Riociguat, BAY63-2521)
Sponsor:   Bayer
Available - verified August 2015

The Effect of Medication Reminder Technology on Medication Adherence and Hypertension Outcomes

Conditions:   Medication Adherence;   Blood Pressure
Intervention:   Device: Medication reminder
Sponsor:   Purdue University
Terminated - verified August 2015

Measurement of Autonomic Cardiovascular Integrity in Persons With SCI

Condition:   Spinal Cord Injury
Intervention:  
Sponsor:   James J. Peters Veterans Affairs Medical Center
Recruiting - verified August 2015

Non-invasive Measurement of Retinal Blood Flow Based on Vessel Analysis and Fourier Domain Optical Coherence Tomography in Patients With Hypertensive Retinopathy

Condition:   Hypertensive Retinopathy
Interventions:   Device: Dynamic Vessel Analyzer;   Other: FDOCT;   Other: Ocular perfusion pressure
Sponsor:   Medical University of Vienna
Recruiting - verified September 2015

Endothelial Function in Patients With Scleroderma or Cirrhosis With and Without Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:  
Sponsor:   The Cleveland Clinic
Recruiting - verified August 2015

Clinical Study to Evaluate the Antihypertensive Efficacy and Changes of Neurohormonal Markers of Fimasartan and Atenolol With Exaggerated Blood Pressure Response During Exercise in Essential Hypertensive Patients

Condition:   Hypertension
Interventions:   Drug: Fimasartan;   Drug: Atenolol
Sponsors:   Boryung Pharmaceutical Co., Ltd;   Severance Hospital
Recruiting - verified August 2015

CVRx Barostim Hypertension Pivotal Trial

Condition:   Uncontrolled Hypertension
Intervention:   Device: Neo Baroreflex Activation Therapy System
Sponsor:   CVRx, Inc.
Active, not recruiting - verified August 2015

Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS)

Condition:   Chagas Disease With Heart Failure
Intervention:   Drug: Aspirin
Sponsors:   Federal University of Bahia;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2015

Renal Artery Contrast-Free Trial

Conditions:   Renal Artery Stenosis;   Kidney Diseases;   Hypertension
Intervention:  
Sponsors:   Central Coast Cardiovascular Research;   Toshiba America Medical Systems, Inc.
Completed - verified August 2015

ActiV.A.C.+ Compression Therapy Versus Compression Therapy Alone for the Treatment of Chronic Venous Ulcerations

Condition:   Chronic Venous Hypertension With Ulcer
Interventions:   Device: ActiVAC System;   Other: Compression therapy
Sponsor:   Georgetown University
Terminated - verified August 2015

Pravastatin for Prevention of Preeclampsia

Condition:   Preeclampsia
Interventions:   Drug: Pravastatin;   Drug: Placebo
Sponsors:   The University of Texas Medical Branch, Galveston;   University of Texas;   University of Pittsburgh;   University of Washington;   Indiana University;   RTI International
Completed - verified August 2015

A Study of RO5093151 in Patients With Ocular Hypertension Or Open Angle Glaucoma

Condition:   Hypertension, Glaucoma, Open-Angle
Interventions:   Drug: Placebo;   Drug: RO5093151
Sponsor:   Hoffmann-La Roche
Completed - verified September 2015

Barostim Neo System in the Treatment of Resistant Hypertension

Condition:   High Blood Pressure
Intervention:   Device: Barostim Neo System
Sponsor:   CVRx, Inc.
Active, not recruiting - verified August 2015

Ferinject® for Iron Deficiency in Idiopathic Pulmonary Arterial Hypertension (IPAH) Patients

Conditions:   Idiopathic Pulmonary Arterial Hypertension (IPAH);   Iron Deficiency
Interventions:   Drug: Saline;   Drug: Ferinject
Sponsor:   Imperial College London
Recruiting - verified August 2015

Dietary Intervention of Stress-Induced Neurovegetative Disorders With a Specific Amino Acid Composition (asn01)

Conditions:   Nervous System Disorder;   Imbalance of Constituents of Food Intake
Interventions:   Dietary Supplement: amino acid composition (asn01);   Other: Placebo
Sponsor:   Kyberg Vital GmbH
Completed - verified September 2015

IMproved PREdiction of Severe Sepsis in the Emergency Department

Conditions:   Systemic Inflammatory Response Syndrome (SIRS);   Sepsis;   Severe Sepsis;   Septic Shock
Intervention:  
Sponsor:   Axis Shield Diagnostics Ltd
Completed - verified September 2015

Inhaled Iloprost in the Treatment of Patients With Pulmonary Hypertension up to 4 Years

Condition:   Pulmonary Hypertension
Intervention:   Drug: Ventavis inhaled (Iloprost, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified August 2015

Efficacy of Ventavis Used in Real-life Setting.

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Inhaled iloprost (Ventavis, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified August 2015

COMPERA / COMPERA-KIDS

Conditions:   Pulmonary Arterial Hypertension (PAH);   Pulmonary Hypertension (PH)
Intervention:  
Sponsors:   Technische Universität Dresden;   GWT-TUD GmbH
Recruiting - verified August 2015

Use of Mobile Technology to Prevent Progression of Pre-hypertension in Latin American Urban Settings

Conditions:   Hypertension;   Prehypertension
Intervention:   Behavioral: Mobile technology to promote lifestyle modification
Sponsors:   Institute of Nutrition of Central America and Panama;   Institute for Clinical Effectiveness and Health Policy;   Universidad Peruana Cayetano Heredia;   RAND
Terminated - verified August 2015

DVDs About Blood Pressure

Condition:   Hypertension
Interventions:   Other: Story-Telling DVD;   Other: Non-Storytelling DVD
Sponsor:   Department of Veterans Affairs
Active, not recruiting - verified September 2015

The Health Outcomes Management and Evaluation (HOME) Study

Conditions:   Diabetes;   Hyperlipidemia;   Heart Disease;   High Blood Pressure
Intervention:   Other: Care team
Sponsors:   Emory University;   National Institute of Mental Health (NIMH)
Active, not recruiting - verified September 2015

Early Primary Prophylaxis of Esophageal Varices

Condition:   Cirrhosis
Interventions:   Drug: Carvedilol;   Drug: Placebo
Sponsor:   Institute of Liver and Biliary Sciences, India
Completed - verified December 2013

Reducing Risk of Recurrence

Conditions:   Stroke;   TIA;   Hypertension;   Hyperlipidemia
Interventions:   Behavioral: TI;   Behavioral: AP
Sponsor:   Department of Veterans Affairs
Completed - verified August 2015

Efficacy and Safety of Topically Applied Medical Therapy for the Treatment of Pediatric Glaucoma

Condition:   Childhood Glaucoma
Intervention:   Drug: Latanoprost, Dorzolamide
Sponsor:   Azienda Ospedaliera Spedali Civili di Brescia
Active, not recruiting - verified August 2015

An Open-Label Extension Trial of UT-15C SR in Subjects With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Treprostinil diethanolamine
Sponsor:   United Therapeutics
Active, not recruiting - verified September 2015

Effects of Telmisartan on Ischemic Cardiovascular Events in High-risk Hypertensive Patients

Conditions:   Acute Myocardial Infarction;   Angina Pectoris;   Myocardial Ischemia;   Acute Coronary Syndrome;   Hypertension
Interventions:   Drug: Micardis (Telmisartan);   Drug: Blopress (Candesartan)
Sponsor:   Kyoto Prefectural University of Medicine
Terminated - verified September 2015

Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis for Variceal Bleeding

Conditions:   Esophageal and Gastric Varices;   Gastrointestinal Hemorrhage
Interventions:   Drug: ceftrioxone;   Drug: ceftrioxone
Sponsor:   Far Eastern Memorial Hospital
Completed - verified January 2009

A Survey to Evaluate the Cardiovascular Risk Status of Subjects With Pre-Diabetes in Hong Kong

Conditions:   Prediabetes;   Cardiovascular Risk Factors
Intervention:   Other: observational, no intervention needed
Sponsor:   Chinese University of Hong Kong
Active, not recruiting - verified August 2015

PTGS1 Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn

Condition:   Persistent Pulmonary Hypertension
Intervention:  
Sponsor:   Medical College of Wisconsin
Recruiting - verified September 2015

Effectivity of Postpartum Dexamethasone for Women With Class I HELLP Syndrome

Condition:   HELLP Syndrome
Interventions:   Drug: dexamethasone;   Drug: Placebo;   Drug: dexamethasone
Sponsor:   Instituto Materno Infantil Prof. Fernando Figueira
Active, not recruiting - verified August 2015

Impact of Multiple Doses of BAY63-2521 on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Patients With Interstitial Lung Disease (ILD) Associated Pulmonary Hypertension (PH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsor:   Bayer
Active, not recruiting - verified August 2015

Comparison of Effects of Telmisartan and Valsartan on Neointima Volume in Diabetes

Conditions:   Hypertension;   Diabetes;   Coronary Artery Disease
Interventions:   Drug: telmisartan;   Drug: valsartan
Sponsor:   Korea University Anam Hospital
Completed - verified September 2015

Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies

Conditions:   Ductus Arteriosus, Patent;   Very Low Birth Weight Infants
Interventions:   Drug: Ibuprofen;   Drug: Indomethacin
Sponsors:   KK Women's and Children's Hospital;   National University Hospital, Singapore;   Cumberland Pharmaceuticals
Withdrawn - verified June 2009

Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia

Conditions:   Pulmonary Hypertension;   Sickle Cell Anemia;   Sickle Cell Disease
Intervention:  
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified August 2015

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