High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Health Management Model Construction and Effect Evaluation of Hypertension Patients Based on Disease-related Health Literacy

Conditions:   Health Literacy;   Hypertension
Intervention:   Behavioral: Health education tools combined with health literacy intervention
Sponsor:   Huzhou Normal University
Not yet recruiting

Technology Coaching Intervention for Black Women With Hypertension

Condition:   Uncontrolled Hypertension
Interventions:   Behavioral: ITEC;   Behavioral: No ITEC
Sponsors:   University of North Carolina, Charlotte;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Endtidal Carbon Dioxide for Earlier Detection of Pulmonary Hypertension

Conditions:   Hypertension, Pulmonary;   Hypertension;Pulmonary;Primary;   Chronic Thromboembolic Pulmonary Hypertension;   Vascular Diseases;   Lung Diseases
Intervention:   Diagnostic Test: Capnography
Sponsor:   University of Giessen
Enrolling by invitation

Pulmonary Hypertension Association Registry

Conditions:   Pulmonary Arterial Hypertension;   Chronic Thromboembolic Pulmonary Hypertension;   Pulmonary Hypertension
Intervention:  
Sponsors:   Pulmonary Hypertension Association, Inc.;   University of Washington, the Collaborative Health Studies Coordinating Center
Recruiting

The Association Between Serum β-hydroxybutyrate and Levels of Systemic Hypertension

Conditions:   Hypertension, Essential;   β-hydroxybutyrate
Intervention:   Other: dietary restriction (salt restriction)
Sponsor:   Sulaiman AlRajhi Colleges
Not yet recruiting

Using Lay Health Advisors to Improve Hypertension Management

Condition:   Hypertension
Intervention:   Behavioral: Lay Health Advisor
Sponsor:   MetroHealth Medical Center
Enrolling by invitation

Hypertension in Patients Hospitalized With COVID-19

Conditions:   COVID-19;   Hypertension
Intervention:  
Sponsor:   Zhenhua Zen
Active, not recruiting

Dapagliflozin on Blood Pressure Variability and Ambulatory Arterial Stiffness Index in Hypertension

Condition:   Hypertension
Interventions:   Drug: Dapagliflozin;   Drug: Placebo - Cap
Sponsor:   University of Guadalajara
Enrolling by invitation

Upfront Combination Pulmonary Arterial Hypertension Therapy

Condition:   Pulmonary Hypertension
Intervention:   Drug: Riociguat Oral Product
Sponsors:   University of Calgary;   Bayer
Recruiting

Natural History Study of Biomarkers in Pulmonary Arterial Hypertension

Conditions:   Pulmonary Disease;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Institutes of Health Clinical Center (CC)
Recruiting

Pilot Randomized Trial of Ambulatory Exercise in Pulmonary Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Behavioral: Usual Care;   Behavioral: Home-based exercise program
Sponsors:   University of Michigan;   Actelion
Not yet recruiting

A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Blood Pressure (Hypertension) and Find Out More About Its Safety

Condition:   Resistant Hypertension
Interventions:   Drug: Aprocitentan 12.5 mg;   Drug: Aprocitentan 25 mg;   Drug: Placebo
Sponsors:   Idorsia Pharmaceuticals Ltd.;   Janssen Biotech, Inc.
Recruiting

Riociguat in Children With Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsors:   Bayer;   Merck Sharp & Dohme Corp.
Active, not recruiting

Clinical Study of Balloon Pulmonary Angioplasty for Patients With Chronic Thromboembolic Pulmonary Hypertension

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Intervention:   Procedure: Ballon pulmonary angioplasty
Sponsor:   Li Xuyan
Recruiting

Comparison of Spironolactone and Amiloride on Home Blood Pressure in Resistant Hypertension

Condition:   Resistant Hypertension
Interventions:   Drug: Spironolactone;   Drug: Amiloride
Sponsor:   Yonsei University
Not yet recruiting

Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Macitentan 10 mg;   Drug: Macitentan 37.5 mg;   Drug: Macitentan 75 mg;   Drug: Placebo
Sponsor:   Actelion
Not yet recruiting

A Study to Investigate the Effect of Extracorporeal Shockwave Lithotripsy on Hypertension

Conditions:   Hypertension;   Renal Stone
Intervention:   Procedure: Extracorporeal shock wave lithotripsy
Sponsor:   Chinese University of Hong Kong
Not yet recruiting

A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension

Condition:   Hypertension, Pulmonary
Interventions:   Drug: Selexipag;   Drug: Placebo
Sponsor:   Janssen Research & Development, LLC
Recruiting

[18F]FES PET/CT in PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: [18F] FES
Sponsor:   University of Pennsylvania
Active, not recruiting

BREMEN Eye Drops Versus Combigan for Open-angle Glaucoma or Intraocular Hypertension

Conditions:   Ocular Hypertension;   Primary Open-angle Glaucoma
Interventions:   Drug: BREMEN eye drops;   Drug: Combigan®
Sponsor:   EMS
Not yet recruiting

Continuing the Conversation: Using Narrative Communication to Support Hypertension Self-management in African American Veterans

Condition:   Hypertension
Interventions:   Behavioral: CTC Intervention;   Behavioral: Control
Sponsor:   VA Office of Research and Development
Not yet recruiting

Impact of Multiple Doses of BAY63-2521 on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Patients With Interstitial Lung Disease (ILD) Associated Pulmonary Hypertension (PH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsor:   Bayer
Active, not recruiting

Mechanisms for Individual Differences in Hypertension in Obstructive Sleep

Conditions:   Sleep Apnea, Obstructive;   Hypertension
Intervention:   Device: Positive Airway Pressure
Sponsors:   University of Pennsylvania;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Identifying Most Effective Treatment Strategies to Control Arterial Hypertension in Sub-Saharan Africa

Condition:   Arterial Hypertension
Interventions:   Other: dual combination;   Other: triple combination;   Other: Standard of care
Sponsors:   University Hospital, Basel, Switzerland;   Swiss National Fund for Scientific Research
Recruiting

Effects of Ground-based Walking Training in Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Other: Ground-based walking training
Sponsor:   Istanbul University
Completed

Differential Diagnosis of Pulmonary Hypertension With Automated Image Analysis

Condition:   Pulmonary Hypertension
Intervention:   Radiation: Thoracic computed tomography
Sponsors:   Medical University of Graz;   Ludwig Boltzmann Institute Lung Vascular Research
Not yet recruiting

Oral CXA-10 in Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: CXA-10
Sponsors:   Gladwin, Mark, MD;   National Heart, Lung, and Blood Institute (NHLBI);   Complexa, Inc.
Active, not recruiting

Pharmacists Intervention to Improve Hypertension Management in Primary Care

Condition:   Hypertension
Intervention:   Behavioral: Referral of hypertensive patients to the attending physician
Sponsors:   Wilhelminenspital Vienna;   Österreichische Apothekerkammer, Landesgeschäftsstelle Niederösterreich;   Association for the Promotion of Research in Atherosclerosis, Thrombosis and Vascular Biology;   Institute for Cardiometabolic Diseases, Karl Landsteiner Society
Completed

Spironolactone for Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   National Institutes of Health Clinical Center (CC);   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   University of Pennsylvania;   University of Maryland, College Park;   Washington Hospital Center;   New England Medical Center, Tufts University School of Medicine
Recruiting

Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)

Condition:   Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Interventions:   Drug: FDC macitentan/tadalafil;   Drug: Macitentan 10 mg;   Drug: Tadalafil 40 mg;   Drug: Placebo FDC;   Drug: Placebo macitentan;   Drug: Placebo tadalafil
Sponsors:   Actelion;   Covance;   Almac Clinical Technologies;   WorldCare Clinical;   Frontier Science Foundation
Recruiting

Apixaban for Intrahepatic Non Cirrhotic Portal Hypertension

Condition:   Intrahepatic Non Cirrhotic Portal Hypertension
Interventions:   Drug: Apixaban;   Drug: Placebo
Sponsor:   Assistance Publique - Hôpitaux de Paris
Suspended

Endothelial Function in Patients With Scleroderma or Cirrhosis With and Without Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:  
Sponsor:   The Cleveland Clinic
Recruiting

Effects of Cocoa on Ambulatory Blood Pressure and Vascular Function in Patients With Stage I Hypertension

Condition:   Hypertension
Interventions:   Dietary Supplement: 5g Cocoa Consumption;   Dietary Supplement: 10g Cocoa Consumption
Sponsors:   Griffin Hospital;   Boston University
Completed

A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunction

Conditions:   Hypertension, Pulmonary;   Ventricular Dysfunction, Left
Interventions:   Drug: Riociguat (Adempas, BAY63-2521);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

DENEX Renal Denervation in Patients With Hypertension on no or 1-3 Antihypertensive Medications (DENEX HTN-KORAS)

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Intervention:   Device: Renal Denervation
Sponsor:   Handok Kalos Medical
Not yet recruiting

Cardiac Metabolic Remodeling After Pulmonary Vasodilator Therapy in Pulmonary Arterial Hypertension: A Pilot Study

Conditions:   Pulmonary Arterial Hypertension;   Right-Sided Heart Failure
Intervention:   Other: PET/MRI
Sponsors:   University of Wisconsin, Madison;   United Therapeutics
Suspended

A Study of Tadalafil in Pediatric Participants With Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Interventions:   Drug: Tadalafil;   Drug: Placebo;   Drug: ERA as specific PAH treatment
Sponsor:   Eli Lilly and Company
Active, not recruiting

Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia

Conditions:   Pulmonary Hypertension;   Sickle Cell Anemia;   Sickle Cell Disease
Intervention:  
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn

Condition:   Pulmonary Hypertension, Familial Persistent, of the Newborn
Interventions:   Drug: placebo;   Drug: iv sildenafil
Sponsor:   Pfizer
Active, not recruiting

Renal Denervation for Management of Drug-Resistant Hypertension

Condition:   Hypertension
Intervention:   Procedure: Renal denervation
Sponsor:   KU Leuven
Completed

Mechanisms of Hypertension in Women With Polycystic Ovary Syndrome

Conditions:   Polycystic Ovary Syndrome;   Hypertension
Interventions:   Drug: GnRH antagonist;   Drug: GnRH antagonist + MethylTESTOSTERone 5 MG
Sponsor:   Yale University
Enrolling by invitation

Targeting of UnControlled Hypertension in Emergency Department

Conditions:   Hypertension;   Cardiovascular Diseases;   Vascular Diseases
Interventions:   Other: HTN Educational Video;   Other: Visual Echocardiogram Image Clips;   Other: Mobile Health and Remote BP monitoring;   Other: Post-Acute Care HTN Transition consultation (PACHT-c)
Sponsors:   University of Illinois at Chicago;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Oral Nitrite in Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction

Conditions:   Pulmonary Hypertension Secondary;   Heart Failure
Interventions:   Drug: Sodium Nitrite;   Drug: Placebo Oral Capsule
Sponsors:   Gladwin, Mark, MD;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

To Compare the Safety and Efficacy of Perrigo's Product to an FDA Approved Product for the Treatment of Glaucoma or Ocular Hypertension in Both Eyes

Conditions:   Glaucoma, Open-Angle;   Ocular Hypertension
Interventions:   Drug: Brinzolamide 1% ophthalmic suspension;   Drug: Azopt 1% Ophthalmic Suspension
Sponsor:   Perrigo Company
Active, not recruiting

Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension

Conditions:   Glaucoma, Open-Angle;   Ocular Hypertension
Interventions:   Drug: Bimatoprost SR;   Drug: Sham Bimatoprost SR;   Procedure: Selective Laser Trabeculoplasty;   Procedure: Sham Selective Laser Trabeculoplasty
Sponsor:   Allergan
Recruiting

Remote Monitoring and Social Support for Hypertension Management

Condition:   Hypertension
Interventions:   Behavioral: Remote Monitoring;   Behavioral: Remote Monitoring + Social Support
Sponsor:   University of Pennsylvania
Active, not recruiting

A Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension

Conditions:   Glaucoma;   Open-Angle Ocular Hypertension
Interventions:   Drug: Bimatoprost SR;   Drug: Sham Bimatoprost SR;   Procedure: Selective Laser Trabeculoplasty;   Procedure: Sham Selective Laser Trabeculoplasty
Sponsor:   Allergan
Active, not recruiting

Safety and Efficacy of a New Ophthalmic Formulation of Bimatoprost in Patients With Open Angle Glaucoma and Ocular Hypertension

Conditions:   Open-Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: bimatoprost 20 µg generation 2;   Drug: bimatoprost 15 µg generation 2;   Drug: bimatoprost 10 µg generation 2;   Drug: bimatoprost 6 µg generation 2;   Drug: bimatoprost 15 µg generation 1;   Drug: bimatoprost 10 µg generation 1;   Drug: bimatoprost 0.03%
Sponsor:   Allergan
Completed

Venous Sinus Stenting With the River Stent in IIH

Condition:   Idiopathic Intracranial Hypertension
Intervention:   Device: Venous sinus stenting (Serenity River)
Sponsor:   Serenity Medical, Inc.
Active, not recruiting

Comparison of Losartan Associated With Indapamide Versus Hyzaar® in the Hypertension Treatment

Condition:   Hypertension
Interventions:   Drug: Indapamide / Losartan;   Drug: Hyzaar®
Sponsor:   EMS
Recruiting

Effects of Flavanoids in Essential Hypertension, Type 2 Diabetes and Healthy Persons

Condition:   Vascular Complications, Diabetic
Interventions:   Dietary Supplement: flavanols (subgroup of polyphenols, subgroup of phenolics, natural substances);   Other: Placebo
Sponsor:   University Ghent
Active, not recruiting

A Long-term Extension Study of Riociguat in Patients With Symptomatic Pulmonary Arterial Hypertension.

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Adempas (Riociguat, BAY63-2521)
Sponsor:   Bayer
Recruiting

Continuous Passive Paracentesis for Intra-abdominal Hypertension

Conditions:   Ascites Hepatic;   Cirrhosis, Liver;   Hypertension, Intraabdominal;   Critical Illness;   Paracentesis
Interventions:   Device: continuous drainage of ascitic fluid using an intra-abdominal double lumen central venous catheter;   Procedure: Ultrasound-guided intermittent large-volume paracentesis
Sponsors:   Centro Hospitalar de Lisboa Central;   NOVA Medical School
Recruiting

Drug Therapy and Surgery in Congenital Heart Disease With Pulmonary Hypertension

Conditions:   Congenital Heart Disease;   Pulmonary Arterial Hypertension
Intervention:   Drug: Sildenafil singly or in association with Bosentan
Sponsors:   University of Sao Paulo General Hospital;   Instituto do Coracao;   Fundação de Amparo à Pesquisa do Estado de São Paulo
Completed

Metformin for Pulmonary Hypertension HFpEF

Conditions:   Pulmonary Hypertension;   Heart Failure
Interventions:   Drug: Metformin;   Drug: Placebo oral capsule
Sponsors:   Marc A. Simon;   National Institute on Aging (NIA)
Active, not recruiting

The MHERO Study (Michigan's Hypertension, Diabetes, and Obesity Education Research Online)

Conditions:   Type2 Diabetes Mellitus;   Hypertension;   PreDiabetes;   Overweight and Obesity
Interventions:   Behavioral: DASH diet;   Behavioral: Very low carbohydrate, ketogenic diet;   Behavioral: Extras
Sponsor:   University of Michigan
Active, not recruiting

A Study to Evaluate the Effect of Latanoprostene Bunod Ophthalmic Solution 0.024% on Episcleral Venous Pressure and Outflow Facility in Participants With Ocular Hypertension

Condition:   Ocular Hypertension
Interventions:   Drug: Latanoprostene Bunod;   Drug: Placebo
Sponsor:   Bausch & Lomb Incorporated
Not yet recruiting

Nebulized MgSO4 in Persistent Pulmonary Hypertension of Newborn

Conditions:   Persistent Fetal Circulation;   Persistent Pulmonary Hypertension of the Newborn;   PPHN
Interventions:   Drug: Nebulized Magnesium Sulfate;   Drug: Intravenous Magnesium Sulfate
Sponsor:   Sohag University
Completed

Behaviorally Enhanced Messages to Increase Medical Check-ups(BEM-IMC)

Condition:   Hypertension
Intervention:   Behavioral: WhatsApp message
Sponsors:   Kelly Ann Schmidtke;   B4Development Foundation (Supreme Committee for Delivery and Legacy);   Nudge Lebanon;   University of Warwick
Completed

The Venous Distension Reflex and Orthostatic Hypertension

Condition:   Blood Pressure
Interventions:   Other: Tilt + external pressure;   Other: Tilt + no external pressure.;   Other: Limb occlusion + negative pressure;   Other: Limb occlusion + no negative pressure
Sponsor:   Milton S. Hershey Medical Center
Recruiting

Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Adempas (Riociguat, BAY63-2521);   Drug: Sildenafil;   Drug: Tadalafil
Sponsor:   Bayer
Completed

A Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7058584 Following 7 Days of Instillation of Eye Drops in Patients With Primary Open Angle Glaucoma or Ocular Hypertension

Conditions:   Glaucoma, Open-angle;   Ocular Hypertension
Interventions:   Drug: 0.01% RO7058584;   Drug: 0.1% RO7058584;   Drug: 1% RO7058584;   Drug: Matching Placebo;   Drug: Latanoprost 0.005%
Sponsor:   Hoffmann-La Roche
Completed

U.S. CTEPH Registry

Conditions:   Chronic Thromboembolic Pulmonary Hypertension (CTEPH);   Pulmonary Hypertension
Intervention:  
Sponsors:   University of California, San Diego;   E Squared Trials and Registries, Inc.
Completed

Long-term Ambrisentan Extension Study for Pediatric Patients Who Participated in AMB112529

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Ambrisentan
Sponsor:   GlaxoSmithKline
Active, not recruiting

Impact of Providing Medical Records in a Patient-Centered, Community Pharmacy Based, HIV Care Model (HIV-MOI)

Conditions:   HIV/AIDS;   Diabetes Mellitus, Type 2;   Hypertension
Intervention:   Other: Medication optimization intervention
Sponsors:   University of North Texas Health Science Center;   University of California, San Francisco;   University of Minnesota;   Walgreens, A Boots Alliance
Recruiting

Evaluation of an Information Pamphlet for Postpartum Women That Had a Hypertensive Pregnancy

Condition:   Hypertension, Pregnancy-Induced
Intervention:   Other: information pamphlet
Sponsor:   Université de Sherbrooke
Active, not recruiting

Fimasartan in the Senior Subjects

Condition:   The Elderly (≥ 70 Years) With Essential Hypertension
Interventions:   Drug: Fimasartan or Fimasartan/Hydrochlorothiazide;   Drug: Perindopril or Perindopril/Indapamide
Sponsor:   Boryung Pharmaceutical Co., Ltd
Completed

Auto-PAP for Pulmonary Hypertension Treatment in Decompensated HF Patients With Sleep Apnea.

Conditions:   Sleep Apnea, Obstructive;   Hypertension, Pulmonary;   Heart Failure
Interventions:   Device: AirSense™ 10 AutoSet;   Other: Standard Medical Therapy
Sponsors:   Albert Einstein Healthcare Network;   Resmed Inc
Completed

SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Active, not recruiting

Coronavirus ACEi/ARB Investigation

Conditions:   Hypertension;   COVID-19
Interventions:   Drug: Thiazide or Thiazide-like diuretics;   Drug: Calcium Channel Blockers;   Drug: ACE inhibitor;   Drug: Angiotensin receptor blocker
Sponsor:   National University of Ireland, Galway, Ireland
Recruiting

Is Procardia XL 60 mg Q Daily Equivalent to 30 mg XL Given Twice Daily?

Conditions:   Hypertension in Pregnancy;   Hypertension in Postpartum
Interventions:   Drug: Procardia XL 30Mg;   Drug: Procardia XL 60Mg
Sponsor:   Icahn School of Medicine at Mount Sinai
Terminated

Online Trial Examining Validity and Reliability of the Shared Decision Making Process Survey

Conditions:   High Cholesterol;   High Blood Pressure;   Colorectal Cancer;   Breast Cancer;   Prostate Cancer
Intervention:  
Sponsors:   Massachusetts General Hospital;   Carol Cosenza, Center for Survey Research at University of Massachusetts, Boston
Not yet recruiting

Genetic Based Analysis in Hypertensive Patients

Conditions:   Hypertension;   Renal Denervation;   Genetic Predisposition
Intervention:   Genetic: Genetic based analysis of identifying predictors of blood pressure in patients after renal denervation
Sponsor:   University of Erlangen-Nürnberg Medical School
Active, not recruiting

Safety and Efficacy Study of PG324 (Netarsudil/Latanoprost 0.02% / 0.005%) Ophthalmic Solution Compared to GANFORT® Ophthalmic Solution in Open Angle Glaucoma or Ocular Hypertension

Conditions:   Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Netarsudil/Latanoprost 0.02%/0.005%;   Drug: GANFORT®
Sponsor:   Aerie Pharmaceuticals
Recruiting

Integrated Distance Management Strategy for Patients With Cardiovascular Diseases in the Context of COVID-19

Conditions:   Angina Pectoris;   Acute Coronary Syndrome;   Coronary Syndrome;   Coronary Artery Disease;   Angioplasty;   Stent Restenosis;   Hypertension;   Heart Failure, Systolic;   Depression, Anxiety;   Covid-19;   Isolation, Social
Intervention:   Other: Tele-medicine platform
Sponsors:   Professor Adrian Covic;   Medical Sciences Academy - Romania;   Victor Babes Clinical Hospital of Infectious Diseases - Bucharest
Recruiting

Safety and Efficacy Assessment of Monoprost® in Comparison With Lumigan® 0.01 % and Lumigan® 0.03% Unit Dose

Conditions:   Primary Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Monoprost;   Drug: Lumigan 0.01%;   Drug: Lumigan 0.03% Unit Dose
Sponsor:   Laboratoires Thea
Completed

MediBeat - HeartBeat Observation Trial

Conditions:   Low Blood Pressure;   Blood Pressure;   High Blood Pressure;   Hypertension;   Hypotension
Interventions:   Device: Contec CMS50EW;   Device: Sphygmomanometer
Sponsors:   SE Health;   Centre for Aging and Brain Health Innovation
Completed

Renin-Angiotensin System Inhibitors and COVID-19

Conditions:   COVID-19;   Hypertension;   Cardiovascular Diseases
Intervention:  
Sponsor:   Societa Italiana dell'Ipertensione Arteriosa
Recruiting

A Novel Non-invasive Technique of Cerebral Compliance and Auto-regulation Assessment

Condition:   Intracranial Hypertension
Interventions:   Diagnostic Test: Transcranial Doppler (TCD) ultrasound monitoring;   Diagnostic Test: Non invasive intracranial compliance monitoring
Sponsors:   University of Sao Paulo;   Brain4Care USA Corp.
Recruiting

Subcutaneous Elafin in Healthy Subjects

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Elafin;   Drug: Placebo
Sponsors:   Roham T. Zamanian;   Duke University;   SRI International
Active, not recruiting

Revavtio Special Investigation for Long-term Use in Pediatric Patients

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Sildenafil
Sponsor:   Pfizer
Recruiting

The KaHOLO Project: Preventing Cardiovascular Disease in Native Hawaiians

Condition:   Hypertension
Intervention:   Behavioral: Hula intervention
Sponsors:   University of Hawaii;   I Ola Lahui, Inc.;   Ke Ola Mamo;   University of Washington;   Hui No Ke Ola Pono, Inc.;   Kula No Na Po'e Hawaii
Active, not recruiting

Effects of Treatment With Biological Agents on Vascular and Cardiac Function in Psoriasis

Condition:   Psoriasis
Interventions:   Drug: etanercept;   Drug: ustekinumab;   Drug: cyclosporine;   Drug: Secukinumab;   Drug: Apremilast
Sponsor:   University of Athens
Recruiting

Measuring Individual Responses to a Wholegrains and Nuts Intervention to Reduce Blood Pressure in Prehypertension

Condition:   Prehypertension
Intervention:   Other: Dietary intervention: nuts and wholegrains with dietary advice for a blood-pressure lowering diet
Sponsors:   University of Aberdeen;   Biotechnology and Biological Sciences Research Council;   Unilever R&D
Not yet recruiting

Renal Nerve Ablation in Chronic Kidney Disease Patients

Conditions:   Hypertension;   Chronic Kidney Disease
Intervention:   Device: Simplicity Catheter
Sponsor:   University of Erlangen-Nürnberg Medical School
Completed

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Condition:   Hypertension
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

Prognostic Factors Keeping Track for Covid19 Pneumonia

Conditions:   Pneumonia, Viral;   Hypertension;   Diabetes Mellitus;   Obesity;   Cardiovascular Diseases;   Obstructive Lung Disease
Intervention:  
Sponsor:   Catholic University of the Sacred Heart
Recruiting

Improving BP Control in Diverse Populations Using BP MAP

Condition:   Hypertension
Interventions:   Other: Self-Guided M.A.P. BP Improvement Program;   Other: Full Support M.A.P. BP Improvement Program
Sponsors:   University of California, San Francisco;   Ochin, Inc.;   Louisiana Public Health Institute;   American Medical Association;   American Heart Association
Active, not recruiting

FibroScan™ in Pediatric Cholestatic Liver Disease (FORCE)

Conditions:   Biliary Atresia;   Alagille Syndrome;   Alpha1 Anti-Trypsin Deficiency;   Portal Hypertension;   Liver Fibrosis;   Cholestasis
Intervention:   Other: Liver Stiffness Measurement (LSM)
Sponsors:   Arbor Research Collaborative for Health;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Suspended

SPYRAL DYSTAL Clinical Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Intervention:   Device: Renal Denervation (Symplicity Spyral™)
Sponsor:   Medtronic Vascular
Recruiting

SMARThealth Pregnancy: Feasibility & Acceptability of a Complex Intervention for High-risk Pregnant Women in Rural India.

Conditions:   Pre-Eclampsia;   Gestational Diabetes;   Anemia
Intervention:   Other: SMARThealth Pregnancy
Sponsors:   University of Oxford;   The George Institute
Recruiting

Effects of Training Based on the Pilates Method on the Blood Pressure of Hypertensive Women

Condition:   Hypertension
Interventions:   Other: Traditional Pilates group;   Other: Modified Pilates group
Sponsors:   João Luiz Q. Durigan;   Catholic University of Brasília
Completed

Pilot for a Community Pharmacy Service Model: Impact of a Pharmacist Monitored Patient Blood Pressure Readings

Condition:   Hypertension
Intervention:   Other: Incentivized Care
Sponsor:   Virginia Commonwealth University
Active, not recruiting

Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Patients With DIABETES Mellitus (OPTIMAL-DIABETES)

Conditions:   Diabetes Mellitus;   High Blood Pressure;   Cardiovascular Diseases;   Cognitive Impairment
Interventions:   Drug: Intensive Control of Systolic Blood Pressure (SBP);   Drug: Standard control of Systolic Blood Pressure (SBP)
Sponsors:   Hospital Israelita Albert Einstein;   Ministry of Health, Brazil
Recruiting

Empowerment and Mobile Technology in the Control of Cardiovascular Risk Factors in Patients With Ischemic Stroke

Conditions:   Ischemic Stroke;   Transient Ischemic Attack;   Atrial Fibrillation;   Hypertension;   Empowerment
Interventions:   Diagnostic Test: ECG monitoring for 3 weeks;   Other: Self-monitoring of BP and self-titration of antihypertensive medication
Sponsor:   Jukka Putaala
Recruiting

A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

Conditions:   PAH;   Pulmonary Hypertension;   Pulmonary Arterial Hypertension;   Hypertension;   Connective Tissue Diseases;   Familial Primary Pulmonary Hypertension;   Vascular Diseases;   Cardiovascular Diseases;   Hypertension, Pulmonary;   Lung Diseases;   Respiratory Tract Disease
Intervention:   Drug: Ralinepag
Sponsor:   United Therapeutics
Enrolling by invitation

Effectiveness of a Natural Ingredient on Obesity

Conditions:   Overweight and Obesity;   High Blood Pressure
Intervention:   Dietary Supplement: dietary supplement consumption
Sponsor:   Universidad Católica San Antonio de Murcia
Completed

Combination Therapy Associating CPAP and Mandibular Advancement Device in OSA

Conditions:   Obstructive Sleep Apnea Syndrome;   Hypertension
Interventions:   Device: Continuous Positive Airway Pressure (CPAP) and patient education;   Device: Mandibular Advancement Device
Sponsors:   University Hospital, Grenoble;   ONIRIS
Recruiting

Diuretic Effect Evaluation of Petroselinum Crispum (Parsley) in Hypertensive Patients

Conditions:   Diurnal Enuresis;   Hypertension
Interventions:   Other: Natural Product Petroselinum crispum (Parsley);   Other: Placebo
Sponsors:   University of Science Malaysia;   Imam Abdulrahman Bin Faisal University
Withdrawn

Accuracy of 1.5 T Versus 3 T Magnetic Resonance Arterial Spin Labeling to Measure Renal Blood Flow

Conditions:   Hypertension;   Chronic Kidney Disease
Intervention:   Other: renal perfusion
Sponsor:   University of Erlangen-Nürnberg Medical School
Completed

Sodium Storage in Singaporeans

Conditions:   Healthy;   Hypertension
Intervention:  
Sponsors:   Jens Titze;   National Heart Centre Singapore
Recruiting

Feasibility Assessment of the Blood Pressure Imager, a Continuous Blood Pressure Monitor

Conditions:   Blood Pressure;   Hypertension
Intervention:  
Sponsor:   Tufts University
Completed

Resveratrol and Cardiovascular Health in the Elderly

Conditions:   Vascular Resistance;   Hypertension
Interventions:   Dietary Supplement: Resveratrol;   Drug: Placebo
Sponsor:   National Institute on Aging (NIA)
Recruiting

Comparing Ascites Relief In Two Standard Treatments: Large Volume Paracentesis Vs. Early Tips Using Viatorr Controlled Expansion Stents

Conditions:   Hypertension, Portal;   Ascites
Interventions:   Device: Gore® Viatorr® Endoprosthesis with controlled expansion;   Procedure: Large Volume Paracentesis with albumin infusion
Sponsors:   University of California, Los Angeles;   W.L.Gore & Associates
Recruiting

Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults

Conditions:   Acute Kidney Injury;   Chronic Kidney Disease;   Hypertension
Interventions:   Drug: Iodohippurate;   Procedure: 24 hour ambulatory Blood Pressure;   Procedure: Peripheral Arterial Tonometry;   Procedure: Pulse Wave Velocity;   Drug: Gadolinium
Sponsors:   University of Florida;   American Society of Nephrology
Withdrawn

Chronic Kidney Disease Clinical Decision Support

Conditions:   Chronic Kidney Diseases;   Hypertension;   Diabetes
Intervention:   Other: CKD enhanced clinical decision support
Sponsors:   HealthPartners Institute;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Suspended

A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Conditions:   PAH;   Pulmonary Hypertension;   Pulmonary Arterial Hypertension;   Hypertension;   Connective Tissue Diseases;   Familial Primary Pulmonary Hypertension;   Vascular Diseases;   Cardiovascular Diseases;   Hypertension, Pulmonary;   Lung Diseases;   Respiratory Tract Disease
Interventions:   Drug: Ralinepag;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting

Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)

Conditions:   Liver Diseases;   Alagille Syndrome;   Alpha 1-Antitrypsin Deficiency
Intervention:  
Sponsors:   Arbor Research Collaborative for Health;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Suspended

Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome

Condition:   Adrenal Tumour With Mild Hypercortisolism
Intervention:   Procedure: Adrenalectomy
Sponsor:   Region Skane
Recruiting

Evaluation of Laser Acupuncture on Health Promotion of Sub-health People

Condition:   Suboptimal Health Status
Intervention:   Device: Low level laser therapy
Sponsor:   Taipei Veterans General Hospital, Taiwan
Recruiting

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

Conditions:   Adrenal Gland Neoplasm;   Hypertension;   Bone Diseases, Metabolic;   Cardiovascular Disease;   Hyperinsulinemia
Intervention:  
Sponsors:   National Human Genome Research Institute (NHGRI);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Periodontal Management in Hypertensive Patients (PERIOTENSION Trial I)

Conditions:   Periodontal Diseases;   Gingivitis;   Hypertension
Interventions:   Behavioral: electric toothbrush;   Procedure: Professional oral hygiene
Sponsor:   University of L'Aquila
Not yet recruiting

Medication Adherence Clinical Decision Support

Conditions:   Hyperlipidemia;   Hypertension;   Diabetes;   Medication Nonadherence
Interventions:   Other: Adherence-enhanced clinical decision support;   Behavioral: ReachOut Adherence intervention
Sponsors:   HealthPartners Institute;   National Heart, Lung, and Blood Institute (NHLBI)
Suspended

Evaluation of a Lifestyle Intervention After Bariatric Surgery

Condition:   Obesity
Intervention:   Behavioral: Lifestyle intervention
Sponsor:   University College, London
Active, not recruiting

Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial

Conditions:   Acute Intracerebral Haemorrhage (ICH);   Hypertension
Interventions:   Drug: telmisartan 20mg, amlodipine 2.5mg, and indapamide 1.25mg;   Drug: Placebo
Sponsor:   The George Institute
Recruiting

Genetics of Type 2 Diabetes in West Africans

Conditions:   Hypertension;   Diabetes
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

Endothelin Antagonism in ANCA Vasculitis

Condition:   Vasculitis
Interventions:   Drug: BQ123;   Drug: BQ123/788;   Drug: Placebo
Sponsors:   University of Edinburgh;   British Heart Foundation
Completed

Genetics of Type 2 Diabetes Among Han Chinese

Conditions:   Diabetes;   Hypertension
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Completed

Influence of Conditional Workout Postpartum on Arterial Stiffness Among Women With Status After Preeclampsia, Superimposed Preeclampsia or HELLP-syndrome

Conditions:   Preeclampsia;   Superimposed Preeclampsia;   HELLP Syndrome
Intervention:   Behavioral: conditional workout
Sponsor:   Martin-Luther-Universität Halle-Wittenberg
Active, not recruiting

E-health Intervention for Cardiac Rehabilitation

Conditions:   Coronary Heart Disease;   Valve Disease, Heart
Interventions:   Behavioral: Virtual Cardiac Rehabilitation Program;   Behavioral: Case Managed Home Program
Sponsor:   Ottawa Heart Institute Research Corporation
Active, not recruiting

Should a Standard Lymphadenectomy Include the No. 16 Lymph Nodes for Patients With Pancreatic Head Adenocarcinoma.

Condition:   Pancreatic Ductal Adenocarcinoma
Interventions:   Procedure: Extended Lymphadenectomy;   Procedure: Standard Lymphadenectomy
Sponsor:   Ruijin Hospital
Recruiting

Pancreatic Stent for Distal Pancreatectomy

Condition:   Distal Pancreatectomy
Intervention:   Device: Pancreatic stent: PSOF COOK®
Sponsor:   Ruijin Hospital
Suspended

Lymphadenectomy for Pancreatic Head Cancer: Standard or Extended?

Condition:   Pancreatic Ductal Adenocarcinoma
Interventions:   Procedure: Pancreaticoduodenectomy with Standard lymphadenectomy;   Procedure: Pancreaticoduodenectomy with Extended lymphadenectomy
Sponsors:   Ruijin Hospital;   Shanghai Zhongshan Hospital;   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Active, not recruiting

The Role of ARTificial Uterine CONtractions in Perinatal Respiratory Morbidity of Term Infants Delivered by Elective Caesarean Section

Condition:   Neonatal Respiratory Distress
Interventions:   Drug: Oxytocin;   Other: Normal saline
Sponsor:   Institute for the Care of Mother and Child, Prague, Czech Republic
Not yet recruiting

Effect of Fucoxanthin on the Components of the Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion

Condition:   Metabolic Syndrome
Interventions:   Drug: Fucoxanthin;   Drug: Placebo
Sponsor:   University of Guadalajara
Recruiting

"Coronavirus SARS-CoV2 and Diabetes Outcomes"

Conditions:   Coronavirus;   Diabetes
Intervention:   Other: no interventional study
Sponsor:   Nantes University Hospital
Not yet recruiting

Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

Conditions:   Systemic Sclerosis;   Diffuse Sclerosis Systemic;   Interstitial Lung Disease;   Pulmonary Hypertension
Interventions:   Drug: Cyclophosphamide;   Drug: Mesna;   Drug: Rituximab;   Drug: Alemtuzumab;   Drug: Thiotepa;   Drug: GM-CSF;   Drug: Intravenous immunoglobulin;   Radiation: Total Body Irradiation
Sponsor:   Paul Szabolcs
Recruiting

Clinico-biological Collection of Subjects With Hyper Lipoprotein a in Reunion Island

Condition:   Cardiovascular Disease
Intervention:   Other: blood lipoprotein (a) test
Sponsor:   Centre Hospitalier Universitaire de la Réunion
Not yet recruiting

Relatively Healthy Male Veterans Observed Over Time to See What Types of Diseases Develop

Condition:   Healthy
Intervention:  
Sponsor:   VA Office of Research and Development
Active, not recruiting

Blood Vessel Study

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   National Institute of Environmental Health Sciences (NIEHS)
Completed

Treatment for Non-Alcoholic Fatty Liver With Different Doses of Vitamin E

Condition:   Fatty Liver
Interventions:   Drug: Vitamin E 200 IU/d;   Drug: Vitamin E 400 IU/d;   Drug: Vitamin E 800 IU/d;   Behavioral: Diet and Exercise
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

A Targeted and Tailored Pharmacist Intervention to Improve Adherence to Antihypertensive Drugs Among Diabetes Patients

Conditions:   Diabetes Mellitus, Type 2;   Hypertension;   Medication Nonadherence
Interventions:   Behavioral: Reminders, habit-based strategies and/or involvement of family member;   Behavioral: Counselling to increase knowledge;   Behavioral: Counselling to increase motivation;   Behavioral: Explore/address other drug related problems;   Behavioral: Usual care based on the Indonesian guideline
Sponsors:   University of Groningen;   Universitas Padjadjaran
Completed

Arm-crank Exercise Training on Cardiovascular Function of Patients With Peripheral Artery Disease

Conditions:   Peripheral Arterial Disease;   Intermittent Claudication;   Hypertension
Interventions:   Other: Arm ergometer;   Other: Treadmill ergometer;   Other: Control group
Sponsors:   Hospital Israelita Albert Einstein;   University of Nove de Julho;   Northumbria University
Suspended

Cohort of Patients With Systemic Sclerosis Within the Framework of the RESO Reference Centre

Conditions:   Scleroderma;   Systemic Sclerosis
Interventions:   Biological: Blood samples;   Other: Biopsy;   Other: Bronchoalveolar samples
Sponsor:   University Hospital, Bordeaux
Not yet recruiting

Diagnosis of Pheochromocytoma

Conditions:   Pheochromocytoma;   Endocrine Disease;   Endocrine Diseases
Interventions:   Drug: ([18F]-DOPA);   Drug: [68Ga]-DOTATATE;   Drug: ([18F]-6F-DA)
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Ketogenic Diet and CPAP Previous Bariatric Surgery

Condition:   Obstructed Sleep Apnea Syndrome in Patient Candidate to Baratric Surgery
Intervention:   Device: Cpap and ketogenic diet
Sponsor:   University of Roma La Sapienza
Recruiting

Optimizing Statin Tratment

Condition:   Diabetes
Intervention:  
Sponsor:   University Hospital, Montpellier
Active, not recruiting

Older Veterans EmpoweRed To Use Regular Exercise (OVERTURE) II

Conditions:   Quality of Life;   Aging
Interventions:   Behavioral: Intervention Group;   Behavioral: Waitlist Control Group
Sponsor:   University of Alabama at Birmingham
Active, not recruiting

Heart Catheterization Using Magnetic Resonance Imaging (MRI) Fluoroscopy and Passive Guidewires

Conditions:   Pulmonary Artery Hypertension;   Congenital Heart Disease;   Structural Heart Disease
Intervention:   Procedure: MRI Right Heart guidewire catheterization
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Alpha Lipoic Acid and Diabetes Mellitus: Potential Effects on Peripheral Neuropathy

Conditions:   Diabetic Polyneuropathy;   Diabetes Mellitus, Type 2
Intervention:   Drug: Alpha lipoic acid
Sponsor:   Benha University
Not yet recruiting

Efficacy of Laser Debridement on Pain and Bacterial Load in Chronic Wounds

Conditions:   Wound Open;   Chronic Venous Hypertension (Idiopathic) With Ulcer;   Diabetic Foot Ulcer
Interventions:   Device: Erbium:Yttrium-Aluminum-Garnet (Er:YAG) Laser Debridement;   Procedure: Scalpel/Curette Debridement
Sponsor:   Stanford University
Completed

Pharmacist Counseling on the Health-related Quality of Life of Patients With Type 2 Diabetes Mellitus

Condition:   Type 2 Diabetes Mellitus
Intervention:   Behavioral: Pharmacist Counseling Intervention
Sponsors:   Universitas Padjadjaran;   Ministry of Research, Technology and Higher Education of the Republic of Indonesia
Completed

Oxygen Savings With Administered Oxygen and High Flow Ambient Air At Rest

Conditions:   Pulmonary Disease, Chronic Obstructive;   Lung Diseases, Interstitial;   Pulmonary Fibrosis;   Hypoxemia;   Dyspnea;   Oxygen Inhalation Therapy
Interventions:   Device: Nasal Delivery of High-Flow Air and Oxygen Therapy;   Device: Nasal Delivery of Oxygen Therapy
Sponsor:   Johns Hopkins University
Not yet recruiting

Joint Use of Electrocardiogram and Transthoracic Echocardiography in an Observational Study to Monitor Cardio-vascular Events in Patients Diagnosed With COVID-19

Conditions:   COVID-19;   Myocardial Injury;   Myocarditis
Intervention:   Diagnostic Test: Electrocardiogram and transthoracic echocardiography
Sponsor:   Groupe Hospitalier Pitie-Salpetriere
Recruiting

Evaluation of Hemodynamic Parameters Following Transjugular Intrahepatic Portosystemic Shunt (TIPS)

Condition:   Refractory Ascites
Interventions:   Procedure: Study - Transjugular Intrahepatic Portosystemic Shunt (TIPS);   Procedure: Control - Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Sponsors:   Medical College of Wisconsin;   Radiological Society of North America
Enrolling by invitation

Long Acting Buprenorphine Injection Compared to Sublingual Buprenorphine/Naloxone Films

Condition:   Opioid Use
Interventions:   Drug: Suboxone® SL;   Drug: Sublocade®
Sponsor:   Wake Forest University Health Sciences
Not yet recruiting

Impact of Time-Restricted Eating on Metabolic and Neuroendocrine Homeostasis, Inflammation and Oxidative Stress in Metabolic Syndrome

Conditions:   Metabolic Syndrome;   Overweight or Obesity;   PreDiabetes;   Weight Loss;   Quality of Life
Intervention:   Behavioral: Time-Restricted Eating
Sponsors:   Nicolaus Copernicus University;   Salk Institute for Biological Studies;   University of California, San Diego;   Center for Obesity and Metabolic Disorders Treatment Bydgoszcz
Recruiting

Novel Single Wave Assessment in Measuring Cardiac Dysfunction and Metabolic Syndrome in Patients With Cancer

Condition:   Malignant Neoplasm
Interventions:   Procedure: Diagnostic Imaging;   Other: Laboratory Biomarker Analysis
Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI)
Recruiting

The Impact of Time Restricted Feeding (TRF) in Improving the Health of Patients With Metabolic Syndrome

Conditions:   Weight Loss;   Metabolic Syndrome;   Overweight and Obesity
Intervention:   Behavioral: Time Restricted Feeding
Sponsors:   University of California, San Diego;   Salk Institute for Biological Studies
Active, not recruiting

Empirical Antibiotics in Acute Inflammatory Gallbladder Disease

Condition:   Cholecystitis, Acute
Intervention:   Procedure: Laparoscopic cholecystectomy
Sponsor:   Seoul St. Mary's Hospital
Not yet recruiting

Contrast Enhanced Ultrasound Imaging for Cerebral Perfusion Measurement in Cerebral Vasospasm After SAH

Condition:   Subarachnoid Hemorrhage
Intervention:  
Sponsor:   University Hospital Inselspital, Berne
Recruiting

Effect of Dapagliflozin on Blood Pressure Variability in Prediabetes and Prehypertension

Conditions:   PreDiabetes;   Prehypertension
Interventions:   Drug: Dapagliflozin;   Drug: Placebo - Cap
Sponsor:   University of Guadalajara
Active, not recruiting

Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome

Conditions:   Brain Tumor;   Metabolic Disturbance;   Inflammatory Response;   Oxygen Deficiency
Interventions:   Drug: Dexmedetomidine;   Other: Normal saline
Sponsor:   Georgia Tsaousi
Recruiting

TOSS Feasibility + Fitbit Community = Reduced Obesity in Older Black Women

Condition:   Obesity
Intervention:   Behavioral: TOSS Feasibility + Fitbit Community = Reduced Obesity in Older Black Women
Sponsor:   University of Alabama at Birmingham
Not yet recruiting

Artificial Intelligence Analysis of Initial Scan Evolution of Traumatic Brain Injured Patient to Predict Neurological Outcome

Condition:   Trauma, Brain
Intervention:   Radiation: CT scan
Sponsor:   University Hospital, Grenoble
Recruiting

Effect of Exenatide LAR or Dulaglutide on the Variability of 24-hour Heart Rate and Blood Pressure in Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Exenatide LAR;   Drug: Dulaglutide
Sponsor:   University of Guadalajara
Recruiting

Apelin as a Potential Treatment for Chronic Kidney Disease

Conditions:   Chronic Kidney Diseases;   Cardiovascular Diseases;   Endothelial Dysfunction
Intervention:   Other: [Pyr]apelin-13
Sponsors:   University of Edinburgh;   Kidney Cancer UK
Recruiting

Post-Surgery Extracorporeal Life Support

Conditions:   Cardiogenic Shock;   Extracorporeal Life Support;   Extracorporeal Membrane Oxygenation Complication;   Post Cardiac Arrest Syndrome;   Post-cardiac Surgery
Intervention:   Procedure: ECLS
Sponsors:   University of Florence;   Sandro Gelsomino;   Edvin Prifti;   Francesco Cabrucci;   Marco Bugetti;   Orlando Parise;   Aleksander Dokollari
Recruiting

Effects of Mitochondrial-targeted Antioxidant on Mild Cognitive Impairment (MCI) Patients

Conditions:   Alzheimer Disease, Early Onset;   Mild Cognitive Impairment
Interventions:   Dietary Supplement: MitoQ;   Dietary Supplement: Placebo
Sponsor:   University of Nebraska, Omaha
Recruiting

Using Health-related Quality of Life (HRQL) in Routine Clinical Care

Conditions:   Chronic Obstructive Pulmonary Disease;   Pulmonary Fibrosis;   Pulmonary Hypertension;   Cystic Fibrosis
Intervention:   Behavioral: HUI score card
Sponsors:   University of Alberta;   Institute of Health Economics, Canada;   Roche Pharma AG
Completed

Cabozantinib in Patients With Hepatocellular Carcinoma (ACTION)

Condition:   Hepatocellular Carcinoma
Intervention:   Drug: Cabozantinib
Sponsors:   Fundacion Clinic per a la Recerca Biomédica;   Apices Soluciones S.L.
Not yet recruiting

Uric Acid Lowering Trial in Youth Onset T2D

Conditions:   Diabetic Kidney Disease;   Hyperuricemia;   Diabetes;   Diabetes Mellitus, Type 2;   Type2 Diabetes;   Type 2 Diabetes Mellitus;   Diabetic Nephropathies;   Diabetes Complications
Intervention:   Drug: Pegloticase 8 MG/ML [Krystexxa]
Sponsor:   University of Colorado Denver School of Medicine Barbara Davis Center
Recruiting

Provider Supported Self-Help Cognitive Behavioral Therapy for Insomnia (Tele-Self CBTI)

Condition:   Insomnia Disorder
Interventions:   Behavioral: Tele-Self CBTI;   Other: Health Education Control
Sponsor:   VA Office of Research and Development
Enrolling by invitation

The NIH Exercise Therapy for Advanced Lung Disease Trials: Response and Adaptation to Aerobic Exercise in Patients With Interstitial Lung Disease

Conditions:   Interstitial Lung Disease;   Idiopathic Pulmonary Fibrosis;   Interstitial Pneumonitis;   Desquamative Interstitial Pneumonia
Interventions:   Other: No intervention;   Other: Aerobic Exercise Training (AET)
Sponsors:   National Institutes of Health Clinical Center (CC);   George Mason University;   Inova Fairfax Hospital
Recruiting

Sirolimus Combined With ATRA for the Treatment of Auto-Immune Anemia

Condition:   Autoimmune Anemia
Intervention:   Drug: sirolimus and ATRA
Sponsor:   Peking Union Medical College Hospital
Not yet recruiting

Impact of an Integrated Obesity Management System on Patient's Care

Condition:   Obesity
Intervention:   Behavioral: 2-day preceptorship on obesity management
Sponsors:   Université de Sherbrooke;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting

EUS-guided Glue Injection for Varices Study

Condition:   Gastroesophageal Varices
Intervention:   Procedure: EUS-guided glue injection
Sponsor:   Chinese University of Hong Kong
Active, not recruiting

Efficacy of Nitric Oxide Administration in Attenuating Ischemia/Reperfusion Injury During Neonatal Cardiopulmonary Bypass

Conditions:   Ischemia/Reperfusion Injury After Neonatal Cardiac Surgery;   Inflammatory Reaction After Neonatal Cardiac Surgery
Interventions:   Drug: Inhaled Nitric Oxide;   Drug: placebo
Sponsors:   Chawki Elzein;   Mallinckrodt
Completed

Genetic Testing to Understand and Address Renal Disease Disparities Across the United States

Condition:   Renal Disease
Intervention:   Diagnostic Test: APOL1 status
Sponsor:   Duke University
Not yet recruiting

Targeting Iatrogenic Cushing's Syndrome With 11β-hydroxysteroid Dehydrogenase Type 1 Inhibition

Condition:   Iatrogenic Cushing's Disease
Interventions:   Drug: AZD4017 and prednisolone;   Drug: Placebo Oral Tablet and prednisolone
Sponsors:   University of Oxford;   AstraZeneca
Recruiting

Reference Values for Plasma Catechols

Conditions:   Healthy Volunteers;   Normal Physiology
Interventions:   Other: Food-Coffee;   Other: Food-Banana;   Other: Food-Olive;   Other: Temp. Manip.
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Cerebral Small Vessel Disease Registry Study

Condition:   Cerebral Small Vessel Diseases
Intervention:  
Sponsor:   Bin Cai
Recruiting

Regorafenib Followed by Nivolumab in Patients With Hepatocellular Carcinoma (GOING)

Condition:   Hepatocellular Carcinoma
Interventions:   Drug: Regorafenib;   Drug: Nivolumab
Sponsors:   Fundacion Clinic per a la Recerca Biomédica;   Apices Soluciones S.L.
Recruiting

Post-prandial Effects of Extra Virgin Olive Oil on Endothelial Function in Adults at Risk for Type 2 Diabetes

Condition:   Type 2 Diabetes
Interventions:   Other: Extra Virgin Olive Oil;   Other: Refined Olive Oil
Sponsor:   Griffin Hospital
Completed

Anti-il6 Treatment of Serious COVID-19 Disease With Threatening Respiratory Failure

Condition:   Corona Virus Disease
Interventions:   Drug: RoActemra iv;   Drug: RoActemra sc;   Drug: Kevzara sc;   Other: Standard medical care
Sponsors:   Marius Henriksen;   Lars Erik Kristensen
Not yet recruiting

Study of the Disease Process of Lymphangioleiomyomatosis

Conditions:   Lung Disease;   Pneumothorax;   Tuberous Sclerosis;   Lymphangioleiomyomatosis
Intervention:   Device: Toshibia Aquilion One CT
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

COVID-19 in Patients With Pre-existing Cirrhosis (COVID-Cirrhosis-CHESS2002): A Multicentre Observational Study

Conditions:   COVID-19;   Liver Cirrhosis
Intervention:  
Sponsors:   Hepatopancreatobiliary Surgery Institute of Gansu Province;   Renmin Hospital of Wuhan University;   LanZhou University;   Minda Hospital Affiliated to Hubei University for Nationalities;   Wuhan Union Hospital, China;   The Central Hospital of Enshi Tujia And Miao Autonomous Prefecture;   Tianjin Second People's Hospital;   Sixth People’s Hospital of Shenyang;   Guangxi Zhuang Autonomous Region;   Shenzhen Third People's Hospital;   Ankang Central Hospital;   Xingtai People's Hospital;   Dalian Sixth People’s Hospital;   The Central Hospital of Lishui City;   The Affiliated Third Hospital of Jiangsu University;   Suizhou Hospital, Hubei University of Medicine
Recruiting

AIH-induced Walking Recovery After Subacute SCI

Condition:   Spinal Cord Injury
Interventions:   Other: Daily acute intermittent hypoxia (dAIH);   Other: dSHAM;   Other: Walking
Sponsors:   Spaulding Rehabilitation Hospital;   United States Department of Defense
Recruiting

Prevalence of Trephined Syndrome After Decompressive Craniectomy

Conditions:   Trephined Syndrome;   Sinking Skin Flap Syndrome;   Traumatic Brain Injury;   Stroke;   Post Operative Hemorrhage;   Post-Op Complication;   Post-Op Infection
Interventions:   Procedure: Decompressive craniectomy;   Procedure: Cranioplasty
Sponsor:   University Hospital, Geneva
Terminated

Randomized Controlled Trial of Efficacy and Safety of Local Anesthetics and Steroids for Chronic Peripheral Post-traumatic Neuropathic Pain

Conditions:   Neuralgia;   Peripheral Neuropathic Pain
Interventions:   Drug: Bupivacaine;   Drug: Depo-Medrol Injectable Product;   Other: Saline (Sodium Chloride) solution;   Drug: Lidocaine
Sponsor:   University Health Network, Toronto
Completed

Acoustic OSA Prediction During Wakefulness and Monitoring During Sleep

Condition:   Obstructive Sleep Apnea
Intervention:  
Sponsor:   University of Manitoba
Not yet recruiting

Levosimendan for Veno-arterial ECMO Weaning

Conditions:   Cardiogenic Shock;   Refractory Shock
Interventions:   Other: Data collection;   Other: Data analysis
Sponsor:   Hospices Civils de Lyon
Completed

European Alport Therapy Registry - European Initiative Towards Delaying Renal Failure in Alport Syndrome

Conditions:   Alport Syndrome;   Hereditary Kidney Disease;   Pediatric Kidney Disease;   Thin Basement Membrane Disease;   Familial Benign Hematuria
Interventions:   Drug: ACE-inhibitor;   Drug: AT1-inhibitor;   Drug: HMG-Coenzyme inhibitor (statin);   Drug: Spironolactone;   Drug: Paricalcitol
Sponsors:   University Hospital Goettingen;   Society for Pediatric Nephrology (Germany);   Deutsche Gesellschaft für Nephrologie;   Alport Selbsthilfe e.V.;   Association pour l'Information et la Recherche sur les Maladies Rénales Génétiques (AIRG);   KfH Foundation Preventive Medicine
Recruiting

Longitudinal Study of Mitochondrial Hepatopathies

Conditions:   Acute Liver Failure;   Mitochondrial Diseases;   End Stage Liver Disease;   Respiratory Chain Deficiencies, Mitochondrial;   Disorder of Fatty Acid Oxidation
Intervention:  
Sponsors:   Arbor Research Collaborative for Health;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   University of Michigan
Suspended

EMBRACE (Evaluation of Maternal and Baby Outcome Registry After Chemoprophylactic Exposure)

Condition:   Pregnancy Related
Intervention:  
Sponsors:   Microbicide Trials Network;   National Institute of Allergy and Infectious Diseases (NIAID);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institutes of Health (NIH);   Gilead Sciences;   CONRAD
Active, not recruiting

Filipino Multicomponent Intervention to Maintain Cognitive Performance in High Risk Population (FINOMAIN)

Condition:   Mild Cognitive Impairment
Interventions:   Behavioral: INDAK (Improving Neurocognition through Dance and Kinesthetics);   Behavioral: Nutrition Counseling;   Behavioral: Standardized Vascular Care
Sponsors:   St. Luke's Medical Center, Philippines;   Department of Health, Philippines;   Nanyang Technological University;   Icahn School of Medicine at Mount Sinai
Active, not recruiting

Bosentan in Myocardium Metabolism and Perfusion Measured by 18F-FDG and 82Rb PET/CT on PAH and CTEPH

Conditions:   Myocardial Dysfunction;   Endothelial Dysfunction
Intervention:  
Sponsor:   University of Lausanne Hospitals
Terminated

Atheroma Reduction With Chloroquine in Patients With the Metabolic Syndrome (ARCH-MS)

Conditions:   Metabolic Syndrome X;   Overweight;   Hypertension;   Dyslipidemias;   Prediabetic State
Interventions:   Drug: Chloroquine;   Drug: Placebo Comparator
Sponsors:   Washington University School of Medicine;   National Heart, Lung, and Blood Institute (NHLBI);   Singulex
Completed

Transcatheter Mitral Valve Repair as Bridge Therapy to Heart Transplantation

Conditions:   Heart Failure;   Mitral Regurgitation;   End-stage Heart Failure
Intervention:   Device: MitraClip
Sponsor:   Scientific Institute San Raffaele
Recruiting

Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

Condition:   CAD
Interventions:   Device: MRI scan x 1 Healthy Volunteer;   Device: MRI scan x 2 Healthy Volunteer;   Device: MRI scan x 2 - CAD patients;   Device: MRI scan x 2- non CAD patients
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

PRESERFLO® MicroShunt Extension Study

Condition:   Primary Open-angle Glaucoma
Interventions:   Device: PRESERFLO® MicroShunt;   Procedure: Trabeculectomy
Sponsor:   InnFocus Inc.
Not yet recruiting

eyeWatch vs. Trabeculectomy RCT (evT)

Condition:   Primary Glaucoma
Intervention:   Device: eyeWatch
Sponsors:   dr. Kaweh Mansouri;   Manchester Royal Eye Hospital
Not yet recruiting

UCP (Ultrasound Cyclo Plasty) in the Treatment of Chinese Patients With Primary Open-angle Glaucoma

Conditions:   Glaucoma;   Glaucoma, Primary Open Angle
Intervention:   Procedure: ultrasound cyclo plasty
Sponsor:   Zhongshan Ophthalmic Center, Sun Yat-sen University
Recruiting

Effect on the Adherence to Glaucoma Eye Drops by Improving Patient Understanding and Using a Tele-reminder System

Condition:   Glaucoma
Intervention:   Device: Personalised card
Sponsor:   National University Health System, Singapore
Completed

Treatment Outcomes of a Novel Glaucoma Tube Shunt Implant for Intraocular Pressure Control in Eyes With Refractory Glaucoma

Conditions:   Glaucoma;   Glaucoma, Open-Angle;   Surgery;   Intraocular Pressure
Intervention:   Device: Paul Glaucoma Implant Surgery
Sponsor:   National University Hospital, Singapore
Completed

XEN-45 Gel Stent Versus Trabeculectomy in Glaucoma: Gold-Standard Pathway Study (GPS)

Condition:   Glaucoma
Interventions:   Device: XEN group;   Procedure: Trabeculectomy
Sponsor:   Allergan
Recruiting

Intracameral Versus Intravitreal Bevacizumab Injection in NVG: RCT

Conditions:   Glaucoma, Neovascular;   Vascular Endothelial Growth Factor Overexpression
Interventions:   Procedure: Intracameral injection;   Procedure: Intravitreal injection
Sponsor:   Prince of Songkla University
Recruiting

A Universal Eye Drop Adherence Monitor to Measure and Improve Adherence to Ocular Medications

Conditions:   Medication Adherence;   Glaucoma
Interventions:   Device: Devers Drop Device (D3) app;   Device: Smart phone calendar app
Sponsors:   Universal Adherence LLC;   National Institutes of Health (NIH);   Oregon State University;   National Eye Institute (NEI)
Not yet recruiting

Safety and Effectiveness of the XEN45 Glaucoma Treatment System in Patients With Angle Closure Glaucoma

Condition:   Glaucoma, Angle-Closure
Intervention:   Device: XEN45
Sponsor:   Allergan
Recruiting

Automatic vs. Manual Optic Disc Planimetry

Condition:   Open Angle Glaucoma
Interventions:   Other: manual planimetry;   Other: automated planimetry
Sponsors:   University of Zurich;   Swiss Federal Institute of Technology
Withdrawn

Reproducibility of RNFL and ONH Measurements in OAG With Heidelberg Spectralis SD-OCT Glaucoma Module Premium Edition

Condition:   Primary Open Angle Glaucoma
Intervention:   Device: RNFL and BMO-MRW SD-OCT
Sponsor:   University of Zurich
Completed

the Pops-titration Versus the Slow-coagulation Cyclophotocoagulation in Treatment of Refractory Glaucoma

Conditions:   Glaucoma;   Intraocular Pressure
Interventions:   Procedure: The pops-titration group;   Procedure: The slow-coagulation group
Sponsor:   Prince of Songkla University
Completed

Progesterone in Expectantly Managed Early-onset Preeclampsia

Condition:   Preeclampsia
Intervention:   Drug: 17 Hydroxyprogesterone Capronate
Sponsor:   Assiut University
Recruiting

Role of ASpirin in Placental and Maternal Endothelial Cell Regulation IN Pre-eclampsia

Condition:   Pre-Eclampsia
Interventions:   Drug: Acetylsalicylic Acid 81 mg;   Drug: Acetylsalicylic Acid 162 mg;   Other: Control
Sponsor:   John O'Brien, MD
Recruiting

Evaluation of the Integrated Radio Frequency Denervation System to Improve Glycemic Control in Type 2 Diabetic Subjects

Condition:   Diabetes Mellitus, Type 2
Intervention:   Device: iRF System Hepatic Denervation
Sponsor:   Metavention
Not yet recruiting

Study of Major Cardiovascular Events in Patients With Nonvalvular Atrial Fibrillation Treated With Rivaroxaban

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

"Post-acute Pickwick Study" (Postacute-Pick-2020)

Conditions:   Acute on Chronic Hypercapnic Respiratory Failure;   Obesity Hypoventilation Syndrome (OHS)
Interventions:   Procedure: "Lifestyle modifications" group (Control);   Procedure: Automatic NIV;   Procedure: CPAP treatment group;   Procedure: NIV treatment groups
Sponsor:   Juan F. Masa
Not yet recruiting

Study of the Life Expectancy of Patients With Metabolic Syndrome After Weight Loss:

Condition:   Obesity
Interventions:   Procedure: gastric bypass;   Dietary Supplement: Hypocaloric diet therapy
Sponsor:   University Medical Center, Kazakhstan
Recruiting

Study of the Effect of Diabetes on the Incidence and the Extent of Coronary Artery Disease

Condition:   Patients Undergoing Coronary Angiography
Intervention:  
Sponsors:   University of Ioannina;   University Hospital, Ioannina;   Catheterization Laboratory of 1st IKA Hospital, Athens
Completed

Effect of Dexmedetomidine on Nol-Index Guided Remifentanil Analgesia

Conditions:   Nociceptive Pain;   Anesthesia;   Opioid Use;   Perioperative/Postoperative Complications
Interventions:   Drug: Dexmedetomidine;   Drug: sodium chloride;   Drug: Remifentanil
Sponsors:   Erasme University Hospital;   Saint-Pierre University Hospital
Completed

Prospective Study on DEXTENZA® Safety And Efficacy Following Concomitant MIGS and Cataract Surgery

Conditions:   Glaucoma;   Cataract
Interventions:   Drug: Dexamethasone Ophthalmic Insert;   Drug: Prednisolone Acetate 1% Oph Susp
Sponsors:   The New York Eye Surgery Center;   Ocular Therapeutix, Inc.
Suspended

Reproducibility of Blood Flowmetry in Human Retina Using the Nidek Laser Speckle Flowgraphy LSFG-NAVI System

Conditions:   Open Angle Glaucoma;   Normal Tension Glaucoma;   Healthy
Intervention:   Diagnostic Test: LASER SPECKLE FLOWGRAPHY
Sponsors:   University of Zurich;   Cantonal Hosptial Aarau, Department of Ophthalmology, Aarau, Switzerland
Recruiting

Angiotensin 2 Receptor (AT2R) in Endothelial Cells in Preeclampsia

Conditions:   Pre-Eclampsia;   Vascular Diseases
Intervention:   Procedure: Omental Biopsy
Sponsors:   University of Wisconsin, Madison;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Comparison of Abdominal Aortic Aneurysm Growth in Adult Smoking Patients Who Either Switch to IQOS, Continue Smoking, or Quit Smoking.

Conditions:   Smoking;   Abdominal Aortic Aneurysm;   IQOS Use
Interventions:   Other: IQOS;   Other: Cigarette;   Other: Smoking Cessation
Sponsor:   Philip Morris Products S.A.
Recruiting

Advanced MRI for Uteroplacental Flow, Perfusion, Oxygenation & Inflammation

Conditions:   Pregnancy;   Obesity;   Preeclampsia
Interventions:   Procedure: Ultrasound Scan;   Procedure: MRI Scan;   Drug: Ferumoxytol
Sponsors:   University of Wisconsin, Madison;   National Institutes of Health (NIH);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting

Safety and Efficacy Study of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-7902-006/E7080-G000-315/LEAP-006)

Condition:   Nonsquamous Non-small Cell Lung Cancer
Interventions:   Biological: Pembrolizumab;   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Pemetrexed;   Drug: Lenvatinib;   Drug: Placebo matching lenvatinib
Sponsors:   Merck Sharp & Dohme Corp.;   Eisai Inc.
Recruiting

Gamification to Increase Mobility in the Hospital

Conditions:   Coronary Artery Disease;   Coronary Heart Disease;   Hypertension;   Diabete Mellitus;   Dyslipidemias;   Obesity;   Heart Failure
Intervention:   Behavioral: Gamification Intervention
Sponsor:   University of Pennsylvania
Not yet recruiting

Randomized Controlled Trial Between Auto-titration and Manual Titration of Non-invasive Ventilation in Obesity Hypoventilation Syndrome

Conditions:   Chronic Hypercapnic Respiratory Failure;   Obesity Hypoventilation Syndrome
Interventions:   Device: Manual Non invasive ventilation titration;   Device: Automatic Non invasive ventilation titration
Sponsor:   Sociedad Española de Neumología y Cirugía Torácica
Recruiting

Cheese Consumption and Human Microvascular Function

Condition:   Microvascular Dysfunction
Interventions:   Drug: Acetylcholine (ACh) Dose Response;   Drug: Local Heating (LH);   Drug: Flow Mediated Dilation with nitroglycerin
Sponsors:   Lacy M. Alexander;   National Dairy Council
Recruiting

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy (CEA);   Device: Carotid Stenting (CAS);   Other: Intensive Medical Management - no CEA;   Other: Intensive Medical Management - no CAS
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Suspended

The NutriNet-Santé Study

Conditions:   Diet, Food, and Nutrition;   Exercise;   Diseases Category;   Cohort Studies;   Adult;   Anthropometry;   Humans;   Internet;   Surveys and Questionnaires;   Mortality
Intervention:  
Sponsors:   University of Paris 13;   Institut National de la Santé Et de la Recherche Médicale, France;   Institut National de la Recherche Agronomique;   Conservatoire national des Arts et Métiers
Recruiting

Metformin as RenoProtector of Progressive Kidney Disease

Condition:   Chronic Kidney Diseases
Interventions:   Drug: Metformin Hydrochloride;   Drug: Placebo Oral Tablet
Sponsor:   Universiteit Antwerpen
Recruiting

Randomized, Open Label Safety Trial of Dapivirine Vaginal Ring and Oral TRUVADA® Use in Pregnancy

Condition:   HIV Infections
Interventions:   Drug: Dapivirine (DPV) Vaginal Ring (VR);   Drug: Truvada Tablet
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting

Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension

Condition:   Adverse Effect
Interventions:   Drug: Norepinephrine;   Drug: Normal saline
Sponsor:   General Hospital of Ningxia Medical University
Recruiting

Oral vs Intravenous Diltiazem for Rapid Atrial Fibrillation/Flutter Trial

Condition:   Atrial Fibrillation and Flutter
Interventions:   Drug: Diltiazem Oral Product;   Drug: Diltiazem Injectable Product
Sponsor:   Virginia Commonwealth University
Active, not recruiting

A Study to Evaluate PF-06730512 in Adults With Focal Segmental Glomerulosclerosis (FSGS)

Condition:   Focal Segmental Glomerulosclerosis (FSGS)
Intervention:   Drug: PF-06730512
Sponsor:   Pfizer
Recruiting

Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE)

Condition:   Asthma
Intervention:  
Sponsors:   AstraZeneca;   Parexel;   MedImmune LLC
Recruiting

Research Study Comparing Insulin Degludec to Insulin Detemir, Together With Insulin Aspart, in Pregnant Women With Type 1 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 1
Interventions:   Drug: Insulin degludec;   Drug: Insulin Aspart;   Drug: Insulin detemir
Sponsor:   Novo Nordisk A/S
Active, not recruiting

Consequences of Doing What Should Not be Done in Primary Care

Conditions:   Overdose;   Adverse Event
Interventions:   Drug: Benzodiazepines;   Drug: Non-steroidal anti-inflammatory drugs;   Drug: paracetamol;   Drug: Antimicrobial agent;   Drug: Lipid-lowering drug;   Diagnostic Test: Prostate cancer;   Radiation: Lumbago;   Drug: Mucolytic;   Drug: Ibuprofen and paracetamol
Sponsors:   Universidad Miguel Hernandez de Elche;   Osasunbidea;   Servicio Madrileño de Salud, Madrid, Spain;   Fondo de Investigacion Sanitaria;   AQuAS;   Agencia de Calidad Sanitaria de Andalucía;   Ministerio de Sanidad, Servicios Sociales e Igualdad;   Servicio Aragonés de Salud;   Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana;   Consellería Sanitat, Generalitat Valenciana;   MurciaSalud;   Osakidetza;   Castilla-La Mancha Health Service
Completed

Tenecteplase in Wake-up Ischaemic Stroke Trial

Conditions:   Ischemic Stroke;   Stroke, Acute
Interventions:   Drug: Tenecteplase;   Other: Control
Sponsors:   University Hospital of North Norway;   UiT The Arctic University of Norway;   The Royal Norwegian Ministry of Health;   Norwegian Health Association
Recruiting

Thromboelastogram in Postdelivery Preeclamptic Patients

Conditions:   Preeclampsia;   Coagulation Disorder;   Pregnancy Complications
Intervention:   Diagnostic Test: Thromboelastogram
Sponsor:   Augusta University
Completed

Individualized Physical Exercise Training and Enhanced Protein Intake During Rehabilitation of Elderly Citizens

Condition:   Rehabilitation
Interventions:   Other: Usual Care;   Other: Usual Care with Protein Supplementation;   Other: Individualized Physical Exercise Training with Protein Supplementation
Sponsors:   University College Absalon;   University of Southern Denmark;   Sundhed og Træning, Slagelse Municipality;   Arla Foods;   Danish Council for Independent Research;   Association of Danish Physiotherapists
Active, not recruiting

Sandostatin LAR and Axitinib vs Pbo in Pnts With Advanced Well-differentiated Non-pancreatic Neuroendocrine Carcinomas

Conditions:   Neuroendocrine Tumors;   Advanced Cancer
Interventions:   Drug: Axitinib;   Drug: Sandostatin LAR;   Drug: Placebo
Sponsors:   Grupo Espanol de Tumores Neuroendocrinos;   Pfizer
Active, not recruiting

Liver Disease in Pregnancy

Conditions:   Pregnancy Disease;   Cirrhosis, Liver;   HELLP Syndrome;   AFLP - Acute Fatty Liver of Pregnancy;   Intrahepatic Cholestasis of Pregnancy
Intervention:  
Sponsors:   King's College Hospital NHS Trust;   European Association for the Study of the Liver
Recruiting

7.0 Tesla Resonance Magnetic Imaging of the Hand in Systemic Sclerosis

Conditions:   Systemic Sclerosis;   7.0 Tesla Magnetic Resonance Imaging;   Hand Vascular Involvement;   Hand Osteoarticular Involvement
Intervention:   Device: 7.0 T RMI
Sponsor:   Poitiers University Hospital
Not yet recruiting

Ghana PrenaBelt Trial: A Positional Therapy Device to Reduce Still-Birth

Conditions:   Sleep;   Pregnancy;   Stillbirth;   Infant, Low Birth Weight;   Infant, Small for Gestational Age;   Infant, Very Low Birth Weight;   Fetal Growth Retardation;   Fetal Hypoxia
Interventions:   Device: PrenaBelt;   Device: Body Position Sensor;   Device: sham-PrenaBelt
Sponsors:   Allan Kember;   Korle-Bu Teaching Hospital, Accra, Ghana;   Grand Challenges Canada;   Innovative Canadians for Change;   Global Innovations for Reproductive Health and Life;   Kaishin Chu Design
Completed

cliNIcal sCEnarios and Pathophysiology of Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Policlinico Casilino ASL RMB
Not yet recruiting

Multiple Doses of DM199 in Patients With Chronic Kidney Disease

Condition:   Kidney Diseases
Intervention:   Drug: DM199
Sponsor:   DiaMedica Therapeutics Inc
Recruiting

Ascertain the Optimal Starting Dose of Mircera Given Subcutaneously for Maintenance Treatment of Anemia in Pediatric Patients With Chronic Kidney Disease on Dialysis or Not Yet on Dialysis.

Conditions:   Anemia;   Renal Insufficiency, Chronic
Intervention:   Drug: Mircera
Sponsor:   Hoffmann-La Roche
Recruiting

Efficacy and Safety of Atacicept in IgA Nephropathy

Condition:   IgA Nephropathy
Interventions:   Drug: Atacicept 25 mg;   Drug: Atacicept 75 mg;   Drug: Placebo;   Drug: Atacicept 150 mg
Sponsors:   EMD Serono Research & Development Institute, Inc.;   Merck KGaA, Darmstadt, Germany
Completed

INTERCOMEX Donor-Derived Cell Free DNA Study

Condition:   Kidney Transplant Rejection
Interventions:   Diagnostic Test: MMDx;   Diagnostic Test: Prospera;   Diagnostic Test: HLA antibody
Sponsors:   University of Alberta;   Natera, Inc.;   One Lambda
Recruiting

A Study to Evaluate the Long-term Safety and Tolerability of Lucerastat in Adult Subjects With Fabry Disease

Condition:   Fabry Disease
Intervention:   Drug: Lucerastat
Sponsor:   Idorsia Pharmaceuticals Ltd.
Recruiting

Study of Safety, Reactogenicity and Immunogenicity of GlaxoSmithKline's (GSK)Respiratory Syncytial Virus (RSV)Maternal Unadjuvanted Vaccine in Healthy Pregnant Women (Aged 18 to 40 Years) and Their Infants

Condition:   Respiratory Syncytial Virus Infections
Interventions:   Biological: RSVPreF3 formulation 2;   Biological: RSVPreF3 formulation 3;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Recruiting

Incidence of Sub-clinical Cystoid Macular Edema After Cataract Surgery

Conditions:   Cataract;   Glaucoma
Interventions:   Device: SD-OCT;   Device: OCT-A
Sponsor:   University of Zurich
Recruiting

Benefit, Usage and Comfort of Treatment of OSA With a Mandibular Advancement Device: Narval Registry

Condition:   Obstructive Sleep Apnea
Intervention:  
Sponsor:   ResMed
Not yet recruiting

Obstetric Antiphospholipid Antibody Syndrome : Contribution of the Evaluation of ADAMTS13 Made at the Diagnosis of Pregnancy on Evaluation the Risk of Pre-eclampsia

Condition:   Antiphospholipid Antibody Syndrome in Pregnancy
Intervention:   Other: To study the prognostic value on the occurrence of pre-eclampsia, ADAMTS13 (ADAMTS13 protein and autoantibodies) in patients diagnosed with oAPS
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Not yet recruiting

Dexamethasone Compared to Conventional Therapy in the Treatment of Acute Pericarditis

Condition:   Pericarditis Acute
Interventions:   Drug: Dexamethasone therapy;   Drug: Conventional Therapy
Sponsor:   Rabin Medical Center
Not yet recruiting

Navigant Study- Treatment Patterns in mCRPC (Metastatic Castrate Resistant Prostate Cancer )

Condition:   Prostatic Neoplasms, Castration-Resistant
Intervention:   Drug: Xofigo (Radium-223 dichloride, BAY88-8223)
Sponsor:   Bayer
Completed

Healthy for my Baby- RCT of a Lifestyle Intervention for Overweight Women in Preconception

Conditions:   Overweight and Obesity;   Pregnancy Complications;   Health Behavior;   Life Style;   Preconception Care
Interventions:   Behavioral: Healthy for my Baby;   Other: Usual Care
Sponsor:   Université de Sherbrooke
Not yet recruiting

MITHRIDATE: Ruxolitinib Versus Hydroxycarbamide or Interferon as First Line Therapy in High Risk Polcythemia Vera

Condition:   Polycythemia Vera
Interventions:   Drug: Ruxolitinib;   Drug: Hydroxycarbamide;   Drug: Interferon-Alpha
Sponsors:   University of Birmingham;   Novartis;   MPN Voice;   National Cancer Institute, France
Recruiting

Determination of the Sensitivity and Specificity of a Smartphone Application to Detect Retinoblastoma

Conditions:   Retinoblastoma;   Cataracts Infantile;   Glaucoma, Congenital;   Leucocoria
Interventions:   Other: CRADLE;   Other: Red reflex testing
Sponsor:   St. Jude Children's Research Hospital
Recruiting

Improved Self-management for Patients on Ventricular Assist Device (VAD)

Conditions:   Ventricular Assist Device;   Self-management;   Psychological Factors
Intervention:   Other: Prevalence Survey
Sponsors:   University of Freiburg;   University Heart Center Freiburg - Bad Krozingen;   Heart and Diabetes Center North-Rhine Westfalia;   German Heart Center;   Heart Center Leipzig - University Hospital
Recruiting

European Prevention of Alzheimer's Dementia (EPAD) Longitudinal Cohort Study (LCS)

Condition:   Alzheimer's Dementia
Intervention:  
Sponsors:   University of Edinburgh;   Innovative Medicines Initiative
Terminated