High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Pulmonary Vascular Disease Phenomics Program PVDOMICS

Condition:   Pulmonary Arterial Hypertension
Intervention:   Other: No Intervention
Sponsors:   The Cleveland Clinic;   Brigham and Women's Hospital;   Columbia University;   Weill Medical College of Cornell University;   Johns Hopkins University;   Mayo Clinic;   University of Arizona;   Vanderbilt University
Recruiting - verified December 2016

Dimethyl Fumarate (DMF) in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension

Conditions:   Systemic Sclerosis;   Pulmonary; Hypertension
Interventions:   Drug: Dimethyl Fumarate (DMF);   Drug: Placebo Oral Tablet
Sponsors:   University of Pittsburgh;   Biogen
Not yet recruiting - verified November 2016

Evaluation of Celecoxib Effects on Amlodipine in Subjects With Existing Hypertension Requiring Antihypertensives

Condition:   Hypertension
Interventions:   Drug: Over-encapsulated 10 mg amlodipine besylate tablet + over-encapsulated 200 mg celecoxib capsule;   Drug: Over-encapsulated 10 mg amlodipine besylate tablet + matched placebo capsule for over-encapsulated celecoxib capsule;   Drug: Matched placebo tablet for over-encapsulated amlodipine besylate tablet + matched placebo capsule for over-encapsulated celecoxib capsule
Sponsor:   Kitov Pharmaceuticals, Ltd.
Recruiting - verified November 2016

A Phase III Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution Compared With Latanoprost Ophthalmic Solution in Subjects With OAG or OHT

Condition:   Open Angle Glaucoma or Ocular Hypertension
Interventions:   Drug: DE-117;   Drug: Latanoprost ophthalmic solution
Sponsor:   Santen Pharmaceutical Co., Ltd.
Recruiting - verified December 2016

Controlling Hypertension After Severe Cerebrovascular Event

Conditions:   Severe Stroke;   Acute Stroke;   Hypertension
Intervention:   Other: Blood pressure management policies
Sponsors:   Xijing Hospital;   Tang-Du Hospital;   Xi'an Central Hospital;   Shaanxi Provincial People's Hospital;   Hanzhong Central Hospital;   Yan'an University Affiliated Hospital
Not yet recruiting - verified November 2016

Community Based Health Education to Manage Uncontrolled Blood Pressure in Surkhet, Nepal

Condition:   Hypertension
Intervention:   Behavioral: Health education with support by trained FCHV
Sponsor:   Bheri Zonal Ayurveda Hospital
Active, not recruiting - verified December 2016

Medication Adherence in Hypertensive Individuals With Bipolar Disorder

Conditions:   Hypertension;   Bipolar Disorder
Interventions:   Behavioral: iTAB-CV Stage 2;   Behavioral: iTAB-CV Stage 1
Sponsor:   Case Western Reserve University
Not yet recruiting - verified December 2016

Doppler Ultrasound Hepatic Vein Waveform as a Non-invasive Tool in the Assessment of Severity of Portal Hypertension

Condition:   Portal Hypertension
Intervention:   Drug: Carvedilol
Sponsors:   Aga Khan University;   Dow University of Health Sciences
Recruiting - verified December 2016

Amlodipine Versus Valsartan for Improvement of Diastolic Dysfunction Associated With Hypertension

Condition:   Hypertension
Interventions:   Drug: Amlodipine;   Drug: Valsartan
Sponsors:   Asan Medical Center;   Yuhan Corporation
Not yet recruiting - verified November 2016

Noninvasive Neuromodulation to Reserve Diastolic Dysfunction

Condition:   Heart Failure, Diastolic
Intervention:   Device: transcutaneous vagus nerve stimulation
Sponsor:   University of Oklahoma
Recruiting - verified December 2016

A Study of Oral Nitrate in Adults With Pulmonary Hypertension With Heart Failure and Preserved Ejection Fraction

Conditions:   Pulmonary; Hypertension;   Heart Failure;   Preserved Ejection Fraction
Interventions:   Drug: Nitrates;   Drug: Nitrates
Sponsors:   University of Pittsburgh;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified December 2016

Obstructive Sleep Apnea and Metabolic Health

Conditions:   Sleep; Apnea;   Metabolism Disorder
Intervention:  
Sponsor:   Ohio State University
Active, not recruiting - verified November 2016

Effects of a Reduction in Renal Function on Cardiovascular Structure and Function

Conditions:   Chronic Kidney Disease;   Hypertrophy, Left Ventricular;   Hypertension
Intervention:   Procedure: Nephrectomy
Sponsor:   University Hospital Birmingham NHS Foundation Trust
Not yet recruiting - verified November 2016

Intracranial Pressure and Brain Function: Effects of Head Down Tilt Upon Brain Perfusion and Cognitive Performance

Condition:   Intracranial Hypertension
Intervention:   Other: 12° head down tilt
Sponsors:   DLR German Aerospace Center;   Forschungszentrum Juelich;   University Hospital, Umeå;   University of Cologne
Completed - verified November 2016

Complete Health Improvement Program (CHIP) Risk Reduction/Claims Evaluation Project

Conditions:   Cardiovascular Diseases;   Diabetes Mellitus;   Hypertension;   Dyslipidemias;   Overweight and Obesity
Intervention:   Behavioral: The Complete Health Improvement Program
Sponsors:   Ohio University;   Touro University
Recruiting - verified November 2016

Pilot to Examine Risk and Feasibility of Remote Management of BP From CKD Through ESRD

Conditions:   Chronic Kidney Disease;   Bloodpressure;   Hypertension
Intervention:   Other: Strict blood pressure control
Sponsor:   University of California, San Francisco
Not yet recruiting - verified November 2016

The Effect of Adding Exercise Training to Optimal Therapy in PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Other: Exercise therapy
Sponsor:   National Health Service, United Kingdom
Recruiting - verified November 2016

Unsupervised Physical Activity in Elderly

Conditions:   Elderly;   Hypertension;   Physical Conditioning
Interventions:   Behavioral: Unsupervised exercise program;   Behavioral: Physical fitness and quality of life
Sponsor:   Universidade Federal de Goias
Completed - verified November 2016

Pre-eclampsia/Eclampsia in Italy Over the Years 2010-2016

Condition:   Preeclampsia/Eclampsia
Intervention:  
Sponsor:   Papa Giovanni XXIII Hospital
Recruiting - verified November 2016

Pradaxa or Warfarin for Prevention of Recurrent DVT in Patients With Angiographically Confirmed Acute Massive Pulmonary Embolism undergoIng Endovascular Mechanical Fragmentation and Thrombolytic Therapy

Conditions:   Dabigatran Etexilate;   Recurrence of DVT;   Pulmonary Embolism;   Warfarin
Interventions:   Drug: Dabigatran Etexilate;   Drug: Warfarin;   Procedure: angiography, tensiometry of pulmonary artery, catheter thrombus fragmentation;   Drug: Pradaxa;   Device: PigTail catheter
Sponsors:   Meshalkin Research Institute of Pathology of Circulation;   Boehringer Ingelheim
Recruiting - verified November 2016

MLS and Glaucoma - RCT

Condition:   Intraocular Pressure
Intervention:   Behavioral: Intervention
Sponsor:   Wolfson Medical Center
Recruiting - verified November 2016

Clinical Efficacy and Safety of Minimally Invasive Glaucoma Surgery on Primary Angle Closure Glaucoma

Condition:   Glaucoma, Angle-Closure
Interventions:   Procedure: ab interno trabeculectomy with Trabectome;   Procedure: trabeculectomy
Sponsor:   Shanghai Eye Disease Prevention and Treatment Center
Not yet recruiting - verified November 2016

Bracing for Patellofemoral Osteoarthritis

Conditions:   Knee Osteoarthritis;   Metabolic Disease
Interventions:   Device: Womac;   Device: Lequesne;   Device: Timed-up-and-go (TUG);   Device: five-times-sit-to-stand-test (FTSST);   Device: Six-minute walk test.;   Device: functional patellofemoral neoprene brace;   Device: neoprene sleeve brace.
Sponsor:   University of Sao Paulo General Hospital
Not yet recruiting - verified December 2016

Effect of Background Noise on Sleep Quality

Condition:   Sleep Onset Insomnia
Intervention:   Device: NIghtingale (R) device for filtered white noise (Cambridge Sound Management, Waltham, MA)
Sponsor:   Brigham and Women's Hospital
Active, not recruiting - verified December 2016

A Clinical Trial to Evaluate the Pharmacokinetics and Safety of Fimasartan and Amlodipine in Healthy Male Subjects

Condition:   Hypertension
Intervention:   Drug: Fimasartan, Amlodipine
Sponsor:   Boryung Pharmaceutical Co., Ltd
Enrolling by invitation - verified September 2016

Study Evaluating OTX-TP in OAG and OH

Conditions:   Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Travoprost;   Other: Placebo Vehicle
Sponsor:   Ocular Therapeutix, Inc.
Recruiting - verified December 2016

Evaluation of Autonomic Modulation in Stroke After Transcranial Direct Current Stimulation and Treadmill Training

Condition:   Stroke
Interventions:   Device: Transcranial direct current stimulation (tDCS);   Device: training on the running belt
Sponsor:   University of Nove de Julho
Not yet recruiting - verified September 2016

A Study to Investigate the Effect of the Study Drug (FE 204205) in Patients With Cirrhotic Portal Hypertension

Condition:   Portal Hypertension
Interventions:   Drug: FE 204205;   Drug: Placebo
Sponsor:   Ferring Pharmaceuticals
Recruiting - verified December 2016

Comprehensive Treatment of Angina in Women With Microvascular Dysfunction

Conditions:   Angina Pectoris;   Coronary Microvascular Disease
Interventions:   Dietary Supplement: Diet;   Behavioral: Training;   Drug: Medication (with statin and ACE-inhibition)
Sponsors:   Bispebjerg Hospital;   University Hospital Bispebjerg and Frederiksberg;   Cambridge Weight Plan Limited
Not yet recruiting - verified November 2016

Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Adempas (Riociguat, BAY63-2521);   Drug: Sildenafil;   Drug: Tadalafil
Sponsor:   Bayer
Not yet recruiting - verified December 2016

Anterior Segment Imaging With Ultrahigh-resolution OCT in Patients With Glaucoma and PEX - a Pilot Study

Condition:   Glaucoma
Intervention:   Drug: Pilocarpine
Sponsor:   Medical University of Vienna
Recruiting - verified December 2016

Virtual Imaging-based Prediction of Hepatic Venous Pressure Gradient

Condition:   Hypertension, Portal
Interventions:   Procedure: HVPG measurement;   Procedure: CTA;   Procedure: Doppler ultrasound
Sponsors:   Nanfang Hospital of Southern Medical University;   Beijing 302 Hospital;   Beijing Shijitan Hospital
Recruiting - verified December 2016

Examination of Ventavis (Iloprost) Inhalation Behavior Using the I-Neb AAD System in Patients With Pulmonary Arterial Hypertension When Switching the Iloprost Nebulizer Solution for Inhalation From 10 μg/mL (V10) to 20 μg/mL (V20)

Condition:   Hypertension, Pulmonary
Interventions:   Drug: Iloprost,(Ventavis, BAYQ6256);   Device: I-Neb AAD system
Sponsor:   Bayer
Active, not recruiting - verified November 2016

OPTImizing Precision of Hypertension Care to Maximize Blood Pressure Control Pilot (OPTI-BP Pilot)

Condition:   High Blood Pressure
Interventions:   Other: HTN PRA App;   Other: Blood Sample
Sponsors:   University of Florida;   OneFlorida Clinical Research Consortium
Active, not recruiting - verified November 2016

Diabetes Complication Control in Community Clinics (D4C) Trial

Conditions:   Diabetes;   Hypertension;   Dyslipidemia;   Cardiovascular Disease
Intervention:   Other: Protocol-based integrated care
Sponsors:   Tulane University;   Xiamen University
Recruiting - verified November 2016

Study of CS-3150 in Hypertensive Patients With Type 2 Diabetes and Albuminuria

Condition:   Hypertension
Intervention:   Drug: CS-3150
Sponsor:   Daiichi Sankyo Co., Ltd.
Recruiting - verified November 2016

Controlling And Lowering Blood Pressure With the MobiusHDTM Device

Condition:   Hypertension
Interventions:   Device: MobiusHD;   Other: Sham Implantation
Sponsor:   Vascular Dynamics, Inc.
Not yet recruiting - verified November 2016

Open-label, Single Arm Trial of BI 695502 in Patients With Previously Untreated Metastatic Colorectal Cancer

Condition:   Colorectal Neoplasms
Interventions:   Drug: BI 695502;   Drug: chemotherapy
Sponsor:   Boehringer Ingelheim
Recruiting - verified December 2016

Efficacy and Safety of TAH Combination in Comparison With Telmisartan/Amlodipine Combination for Essential Hypertension Patients

Condition:   Essential Hypertension
Interventions:   Drug: Telmisartan/Amlodipine+Hydrochlorothiazide;   Drug: Telmisartan/Amlodipine;   Drug: Placebo for Hydrochlorothiazide
Sponsor:   IlDong Pharmaceutical Co Ltd
Completed - verified January 2016

Effectiveness of a Mobile Technology Intervention for the Treatment of Depression

Conditions:   Depression;   Diabetes;   Hypertension
Intervention:   Behavioral: CONEMO
Sponsors:   University of Sao Paulo General Hospital;   National Institute of Mental Health (NIMH);   Universidad Peruana Cayetano Heredia;   London School of Hygiene and Tropical Medicine;   Northwestern University
Recruiting - verified November 2016

Safety and Efficacy of SIMBRINZA® BID as an Adjunctive to DUOTRAV®

Conditions:   Open-angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Brinzolamide 1%/Brimonidine 0.2% suspension;   Drug: Brinzolamide/Brimonidine vehicle;   Drug: Travoprost 0.004%/Timolol 0.5% solution
Sponsor:   Alcon Research
Recruiting - verified November 2016

Long-term Study of CS-3150 as Monotherapy or in Combination With Other Antihypertensive Drug in Japanese Patients With Essential Hypertension

Condition:   Essential Hypertension
Intervention:   Drug: CS-3150
Sponsor:   Daiichi Sankyo Co., Ltd.
Recruiting - verified November 2016

Blood Pressure Follow-up Study in Two Chinese Cohorts(C-BPCS)

Condition:   Hypertension
Intervention:   Other: Incidence and risk factors of hypertension
Sponsor:   First Affiliated Hospital Xi'an Jiaotong University
Recruiting - verified November 2016

CMR in Type 2 Diabetes Mellitus Patients

Conditions:   Diabetes Mellitus, Type 2;   Heart Disease
Interventions:   Other: Cardiac Magnetic Resonance Imaging (CMR);   Other: Echocardiography;   Other: Bood samples
Sponsor:   Slagelse Hospital
Recruiting - verified November 2016

Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension - CATALYST

Condition:   Connective Tissue Disease-Associated Pulmonary Arterial Hypertension
Interventions:   Drug: Placebo capsules;   Drug: Bardoxolone methyl capsules
Sponsor:   Reata Pharmaceuticals, Inc.
Recruiting - verified December 2016

A Study of the ReCor Medical Paradise System in Clinical Hypertension

Conditions:   Hypertension;   Vascular Diseases
Interventions:   Device: The Paradise® Renal Denervation Ultrasound System;   Device: Sham Procedure
Sponsor:   ReCor Medical, Inc.
Recruiting - verified July 2016

Point of Care UltraSound by Surgeons

Conditions:   Biliary Calculi;   Cholecystitis, Acute;   Cholecystitis, Chronic;   Cholelithiasis;   Calculus of Bile Duct With Cholangitis;   Acute Diverticulitis;   Diverticulosis;   Colitis;   Perforation of Colon;   Abscess
Interventions:   Device: Bedside performed Ultrasound Scan by the surgeon;   Other: Radiology report;   Procedure: Intra-operative findings
Sponsors:   Connolly Hospital Blanchardstown;   Royal College of Surgeons, Ireland;   Modular UltraSound ESTES Course (MUSEC);   European Society for Trauma and Emergency Surgery (ESTES)
Recruiting - verified November 2016

A Study Investigating Routine Practice of Chronic Thromboembolic Pulmonary Hypertension Management in EMEA Countries

Condition:   Hypertension, Pulmonary
Intervention:   Other: Standard of care
Sponsor:   Bayer
Recruiting - verified November 2016

Metabolic Imaging of the Heart Using Hyperpolarized (13C) Pyruvate Injection

Conditions:   Hypertension;   Hypertrophy
Intervention:   Drug: Hyperpolarized (13) Pyruvate Injection
Sponsor:   Sunnybrook Health Sciences Centre
Recruiting - verified December 2016

Monitoring Changes in Blood Pressure

Condition:   Blood Pressure
Intervention:   Device: EarlySense (Passive monitoring)
Sponsor:   EarlySense Ltd.
Completed - verified September 2016

Early Detection of Pulmonary- and Pulmonary Vascular Disease in Sjögren Syndrome

Conditions:   Sjögren Syndrome;   Pulmonary Hypertension
Intervention:  
Sponsor:   Medical University of Graz
Recruiting - verified November 2016

Text Messaging to Promote Walking Among Latino Adults at Risk for Peripheral Arterial Disease

Condition:   Peripheral Arterial Disease
Interventions:   Other: Text Messages;   Other: Phone Calls;   Other: Handout
Sponsors:   University of Kansas Medical Center;   National Institute on Aging (NIA)
Active, not recruiting - verified November 2016

Impact of Particulate Matter on Mothers and Babies in Antwerp (IPANEMA)

Conditions:   Pregnancy;   Preeclampsia
Intervention:   Other: amount of fine dust and other environmental exposure
Sponsor:   Universiteit Antwerpen
Recruiting - verified November 2016

Study of Trabodenoson in Adults With Ocular Hypertension or Primary Open-angle Glaucoma

Conditions:   Primary Open-Angle Glaucoma (POAG);   Ocular Hypertension (OHT)
Interventions:   Drug: trabodenoson 4.5% BID;   Drug: trabodenoson 6.0% QD;   Drug: trabodenoson 3.0% QD;   Drug: timolol 0.5% BID;   Drug: placebo BID
Sponsor:   Inotek Pharmaceuticals Corporation
Completed - verified December 2016

Atorvastatin Effectiveness and Safety in Cardiology Patients in Real World Setting

Condition:   Coronary Artery Disease, Hypercholesterolemia, Hypertension
Intervention:   Other: No intervention
Sponsor:   Pfizer
Recruiting - verified November 2016

Optical Angiography in Glaucoma

Condition:   Glaucoma
Intervention:   Device: Optical angiography based on OCT
Sponsor:   Medical University of Vienna
Recruiting - verified November 2016

How Accurately Does the Diopsys Visual Evoked Potential (VEP) Vision Testing System Detect Glaucoma?

Condition:   Glaucoma Diagnosis
Interventions:   Device: Optical Coherence Tomography;   Device: Diopsys Visual evoked potential (VEP)
Sponsor:   Wills Eye
Completed - verified November 2016

Improving Access to Eye Care in Glaucoma Patients

Condition:   Glaucoma
Intervention:   Behavioral: Reminder letter Intervention
Sponsors:   Wills Eye;   Thomas Jefferson University
Completed - verified November 2016

Impact of Best Practice Alerts in Cardiology Outpatient Clinics

Conditions:   Hypertension;   Atrial Fibrillation
Intervention:   Other: Best Practice Alert based in the Electronic Medical Record
Sponsor:   Duke University
Completed - verified November 2016

SPYRAL HTN-ON MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Recruiting - verified December 2016

SPYRAL HTN-OFF MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Recruiting - verified December 2016

Latanoprost Preserved Versus Unpreserved: Effect on Tear Film Thickness as Measured With OCT

Conditions:   Glaucoma;   Ocular Hypertension
Interventions:   Drug: Preservative-free latanoprost 50µg/ml;   Drug: Preserved latanoprost 0.005%
Sponsor:   Medical University of Vienna
Recruiting - verified December 2016

Prospective, Non-interventional, Multi-center, Post-authorization Safety Study of Riociguat for Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Recruiting - verified November 2016

PORtopulmonary Hypertension Treatment wIth maCitentan ─ a randOmized Clinical Trial

Condition:   Portopulmonary Hypertension
Interventions:   Drug: Macitentan;   Other: Placebo
Sponsor:   Actelion
Recruiting - verified November 2016

Multiple Sclerosis: Associated Cardiometabolic Risks and Impact of Exercise Therapy

Conditions:   Multiple Sclerosis;   Healthy Controls
Intervention:   Behavioral: Physical exercise
Sponsor:   Bert Op't Eijnde
Completed - verified November 2016

Palestinian Perineum and Birth Complication Study

Condition:   Complication of Labor and Delivery
Interventions:   Behavioral: Education by animated training video;   Procedure: Interactive hands-on bedside training
Sponsors:   Oslo University Hospital;   Croydon University Hospital;   University of Oslo;   Birzeit University Palestine;   University of Birmingham
Recruiting - verified November 2016

Safety and Efficacy of ENV515 Travoprost Extended Release (XR) in Patients With Bilateral Ocular Hypertension or Primary Open Angle Glaucoma

Condition:   Glaucoma and Ocular Hypertension
Interventions:   Drug: ENV515 Travoprost XR;   Drug: TRAVATAN Z;   Drug: Timolol maleate ophthalmic solution 0.5%
Sponsor:   Envisia Therapeutics
Active, not recruiting - verified December 2016

Does Benign Prostatic Obstruction Cause Hypertension?

Conditions:   Prostatic Hyperplasia;   Hypertension
Intervention:   Procedure: 24-hr ambulatory blood pressure measurement
Sponsors:   St. Olavs Hospital;   Norwegian University of Science and Technology
Recruiting - verified December 2016

Efficacy and Safety of Brinzolamide/Brimonidine Fixed Combination BID Compared to Brinzolamide BID Plus Brimonidine BID in Subjects With Open-Angle Glaucoma (OAG) or Ocular Hypertension (OHT)

Conditions:   Open-Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Brinzolamide 10 mg/mL / Brimonidine 2 mg/mL fixed combination eye drops, suspension;   Drug: Brinzolamide 10 mg/mL eye drops, suspension;   Drug: Brimonidine 2 mg/mL eye drops, solution;   Drug: Vehicle
Sponsor:   Alcon Research
Completed - verified December 2016

Self-management of Postnatal Anti-hypertensive Treatment: a Trial Development Pilot Study

Conditions:   Pre-Eclampsia;   Hypertension, Pregnancy-Induced
Intervention:   Other: Self-management of postnatal anti-hypertensive treatment
Sponsors:   University of Oxford;   National Institute for Health Research, United Kingdom
Completed - verified May 2016

Macronutrient Effects on Alzheimer's Disease (MEAL-2)

Conditions:   Prediabetic State;   Insulin Resistance;   Middle Age;   Prehypertension;   Mild Cognitive Impairment
Interventions:   Other: Low Diet;   Other: High Diet
Sponsor:   Wake Forest School of Medicine
Completed - verified November 2016

Comparison Study of Glaucoma Eye Care Follow-Up Adherence in a High Risk Population

Condition:   Glaucoma
Interventions:   Behavioral: Efficacy-patient navigator to improve follow-up adherence;   Behavioral: Office-Based Usual Care
Sponsors:   Wills Eye;   Partridge Foundation
Completed - verified November 2016

Methylprednisolone for Children With Severe Mycoplasma Pneumoniae Pneumonia (MCMP)

Condition:   Mycoplasma Pneumoniae Pneumonia
Intervention:   Drug: methylprednisolone
Sponsors:   Beijing Children's Hospital;   Shengjing Hospital;   Capital Institute of Pediatrics, China;   Children's Hospital of Changchun;   Women and Children's Health Hospital of yinchuan City
Recruiting - verified December 2016

The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial II

Condition:   Intracerebral Hemorrhage
Intervention:   Drug: labetalol/hydralazine/enalapril
Sponsor:   University of Alberta
Recruiting - verified November 2016

Phase III Trial BI 695502 Plus Chemotherapy vs. Avastin® Plus Chemotherapy in Patients With Lung Cancer

Condition:   Carcinoma, Non-Small-Cell Lung
Interventions:   Drug: Chemotherapy;   Drug: BI 695502;   Drug: bevacizumab;   Drug: Chemotherapy
Sponsor:   Boehringer Ingelheim
Recruiting - verified December 2016

AOP2014 vs. BAT in Patients With Polycythemia Vera Who Previously Participated in the PROUD-PV Study.

Condition:   Polycythemia Vera
Interventions:   Drug: Pegylated-Proline-interferon alpha-2b;   Drug: Best available therapy (BAT)
Sponsors:   AOP Orphan Pharmaceuticals AG;   PharmaEssentia (Co-Sponsor for USA)
Active, not recruiting - verified November 2016

Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH )

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Recruiting - verified November 2016

Lipidomics Screening of Anti-inflammatory Drugs and Drug Candidates in Vitro - Part A

Condition:   Healthy
Intervention:   Procedure: Blood draw
Sponsors:   University of Pennsylvania;   Eli Lilly and Company
Recruiting - verified November 2016

To Evaluate the Effect of Liraglutide on Ambulatory Blood Pressure-A Pilot Study

Conditions:   Diabetes Mellitus, Non-Insulin-Dependent;   Hypertensive Disease
Intervention:   Drug: Liraglutide or Placebo
Sponsors:   Tulane University Health Sciences Center;   Novo Nordisk A/S
Completed - verified December 2016

Monotherapy-Controlled Study of Nifedipine Gastrointestinal Therapeutic System and Candesartan Cilexetil in Combination in Subjects With Essential Hypertension Inadequately Controlled on Candesartan Cilexetil

Condition:   Hypertension
Interventions:   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106);   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106);   Drug: Candesartan Cilexetil;   Drug: Candesartan matching placebo;   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106) 30/16mg matching placebo;   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106)
Sponsor:   Bayer
Withdrawn - verified December 2016

Changes in Ocular Rigidity After Trabeculectomy in Patients With POAG

Conditions:   Glaucoma;   Primary Open Angle Glaucoma;   Pseudoexfoliation Glaucoma
Intervention:   Other: Changes in Ocular rigidity
Sponsor:   Medical University of Vienna
Recruiting - verified December 2016

Effect of Renin-angiotensin-system Blockade on Urinary Free Light Chains in Patients With Type 2 Diabetes Mellitus

Conditions:   Type 2 Diabetes;   Hypertension
Intervention:   Drug: amlodipine, hydralazine, terazosin or hydrochlorothiazide
Sponsor:   Tulane University Health Sciences Center
Recruiting - verified December 2016

Rural Lifestyle Eating and Activity Program (Rural LEAP)

Condition:   Obesity
Interventions:   Behavioral: Lifestyle intervention;   Behavioral: Health education control;   Behavioral: Individual;   Behavioral: All Groups
Sponsors:   University of Florida;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified November 2016

Evaluating the Effects of EECP on Circulation, Blood Glucose Level and Blood Pressure in Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus
Intervention:  
Sponsor:   David Grant U.S. Air Force Medical Center
Withdrawn - verified December 2016

Prospects for the Prevention of Pregnancy-induced Hypertension and Preeclampsia Trial

Condition:   Pregnancy Induced Hypertension
Interventions:   Drug: Combined aspirin and multinutrient supplement;   Other: Daily text reminder text messages
Sponsors:   UMC Utrecht;   Ghana Health Services;   University of Ghana
Not yet recruiting - verified November 2016

Roxadustat in the Treatment of Anemia in Chronic Kidney Disease (CKD) Patients, Not on Dialysis, in Comparison to Darbepoetin Alfa

Condition:   Anemia in Chronic Kidney Disease in Non-dialysis Patients
Interventions:   Drug: Roxadustat;   Drug: darbepoetin alfa
Sponsors:   Astellas Pharma Europe B.V.;   FibroGen
Recruiting - verified December 2016

Essential Hypotension and Adaptability Registry

Conditions:   Blood Pressure;   Depression;   Panic Attack;   Fibromyalgia;   POTS;   Inappropriate Sinus Tachycardia;   Coronary Heart Disease;   Acute Coronary Syndrome (ACS);   Acute Myocardial Infarction (AMI);   Cerebrovascular Disease (CVD);   Transient Ischemic Attack (TIA);   Atrial Fibrillation;   Diabetes Mellitus;   Cancer;   Systolic Heart Failure;   Diastolic Heart Failure;   Chronic Fatigue Syndrome;   Syncope;   Vasovagal Syncope
Intervention:  
Sponsor:   CES University
Recruiting - verified November 2016

GENetic & Immunologic Abnomalies in Systemic Lupus Erythematosus

Condition:   Systemic Lupus Erythematosus (SLE)
Intervention:   Genetic: Blood sampling
Sponsor:   Hospices Civils de Lyon
Completed - verified December 2016

Blood Flow Regulation in Glaucoma

Condition:   Glaucoma
Intervention:   Other: Isometric exercise
Sponsor:   Medical University of Vienna
Recruiting - verified December 2016

Is a Smartphone Application Effective as an Oral Medication Adherence Aid

Conditions:   Hypertension;   Diabetes;   Dyslipidemia
Intervention:   Other: Medication Adherence Smartphone App
Sponsor:   University of Arkansas
Recruiting - verified November 2016

The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Terminated - verified December 2016

Evaluation of Sickle Cell Liver Disease

Condition:   Sickle Cell Disease
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified September 2016

Boramae Hospital Liver Cirrhosis Patient Cohort Study

Conditions:   Liver Cirrhosis;   Hepatocellular Carcinoma
Interventions:   Procedure: Liver biopsy;   Device: Hepatic venous pressure gradient (HVPG) measurement
Sponsor:   Seoul National University Boramae Hospital
Recruiting - verified November 2016

A Toolbox Approach to Obesity Treatment in Primary Care

Condition:   Obesity
Interventions:   Behavioral: Commercial weight loss program;   Behavioral: Colorado Weigh;   Dietary Supplement: Meal replacements;   Drug: Obesity pharmacotherapy;   Behavioral: Recreation center passes
Sponsor:   Denver Health and Hospital Authority
Active, not recruiting - verified November 2016

Controlling and Lowering Blood Pressure With The MOBIUSHD™ (CALM-FIM_EUR)

Condition:   Hypertension
Intervention:   Device: MobiusHD
Sponsor:   Vascular Dynamics, Inc.
Active, not recruiting - verified November 2016

Community Level Interventions for Pre-eclampsia

Conditions:   Pre-eclampsia;   Hypertension, Pregnancy Induced
Interventions:   Behavioral: Community Engagement;   Device: PIERS on the Move mHealth decision aid;   Drug: Magnesium Sulfate;   Drug: Methyldopa
Sponsors:   University of British Columbia;   Bill and Melinda Gates Foundation;   Olabisi Onabanjo University;   Centro de Investigacao em Saude de Manhica;   Aga Khan University;   Jawaharlal Nehru Medical College
Recruiting - verified November 2016

ACE Inhibitors Combined With Exercise for Seniors - Pilot Study

Conditions:   Hypertension;   Aging
Interventions:   Behavioral: Exercise;   Drug: ACE inhibitor + exercise;   Drug: Thiazide diuretic + exercise;   Drug: Angiotensin receptor blocker + exercise
Sponsors:   University of Florida;   American Heart Association
Recruiting - verified November 2016

Assessment of Optic Nerve Radiation in Patients With Glaucoma and Ocular Hypertension by 7 Tesla Diffusion Tensor Imaging

Conditions:   Primary Open Angle Glaucoma;   Ocular Hypertension;   Normal Tension Glaucoma
Interventions:   Device: 7-Tesla MRI;   Other: Optical Coherence Tomography;   Other: Heidelberg Retina Tomography;   Other: Scanning Laser Polarimetry;   Other: Humphrey Perimetry;   Other: Applanation Tonometry
Sponsor:   Medical University of Vienna
Recruiting - verified December 2016

Hypertension Control Program in Argentina (HCPIA)

Condition:   Hypertension
Intervention:   Behavioral: Comprehensive Intervention
Sponsors:   Tulane University;   National Heart, Lung, and Blood Institute (NHLBI);   Institute for Clinical Effectiveness and Health Policy
Completed - verified November 2016

Non-invasive Diagnostics of Pulmonary Hypertension With Dual Energy Computed Tomography

Condition:   Pulmonary Arterial Hypertension
Intervention:   Radiation: Dual-energy computed tomography investigation
Sponsors:   Medical University of Graz;   Ludwig Boltzmann Gesellschaft
Recruiting - verified November 2016

Controlling and Lowering Blood Pressure With The MOBIUSHD™

Condition:   Hypertension
Intervention:   Device: MobiusHD™
Sponsor:   Vascular Dynamics, Inc.
Recruiting - verified November 2016

A Study of Tadalafil in Pediatric Participants With Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Interventions:   Drug: Tadalafil;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Recruiting - verified November 2016

Renal Denervation in Patients With Chronic Kidney Disease

Condition:   Chronic Kidney Disease
Intervention:   Procedure: Renal Denervation
Sponsor:   Regina Qu'Appelle Health Region
Active, not recruiting - verified December 2016

Heart Outcomes Prevention and Evaluation 4

Conditions:   Hypertension;   Cardiovascular Disease
Interventions:   Other: Intervention;   Other: Usual Care
Sponsors:   Hamilton Health Sciences Corporation;   Population Health Research Institute;   Canadian Institutes of Health Research (CIHR);   Grand Challenges Canada;   Global Alliance for Chronic Diseases
Recruiting - verified November 2016

A Study in Maintenance Kidney Transplant Recipients Following Conversion to Nulojix® (Belatacept)-Based

Condition:   Kidney Transplantation
Interventions:   Drug: Belatacept;   Drug: Tacrolimus;   Drug: Cyclosporine
Sponsor:   Bristol-Myers Squibb
Recruiting - verified June 2016

Non-invasive Measurement of Retinal Blood Flow Based on Vessel Analysis and Fourier Domain Optical Coherence Tomography in Patients With Hypertensive Retinopathy

Condition:   Hypertensive Retinopathy
Interventions:   Device: Dynamic Vessel Analyzer;   Other: FDOCT;   Other: Ocular perfusion pressure
Sponsor:   Medical University of Vienna
Recruiting - verified December 2016

Natural History Study of Biomarkers in Pulmonary Arterial Hypertension

Conditions:   Pulmonary Disease;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Institutes of Health Clinical Center (CC)
Recruiting - verified November 2016

Effect of Topical Glaucoma Therapy on Tear Film Stability in Healthy Subjects

Condition:   Healthy
Interventions:   Drug: Timoptic® 0.5%;   Drug: Timophtal sine® 0.5%;   Device: Genteal HA®;   Device: Hylo-Comod®;   Device: Thealoz®
Sponsor:   Medical University of Vienna
Terminated - verified December 2016

A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn

Condition:   Pulmonary Hypertension, Familial Persistent, of the Newborn
Interventions:   Drug: placebo;   Drug: iv sildenafil
Sponsor:   Pfizer
Recruiting - verified November 2016

Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis

Conditions:   Acidosis, Renal Tubular;   Nephrolithiasis;   Vacuolar Proton-Translocating ATPases
Intervention:   Drug: Furosemide-Fludrocortisone-Test (test for urinary acidification)
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified November 2016

An HIV Intervention for Black Men at Risk - The Enhanced Sexual Health Intervention for Men (ES-HIM)

Conditions:   HIV;   Depression;   Posttraumatic Stress Disorder
Interventions:   Behavioral: Enhanced Sexual Health Intervention for Men (ES-HIM);   Behavioral: Health Promotion (HP) Comparison Arm
Sponsors:   University of California, Los Angeles;   National Institute of Mental Health (NIMH)
Completed - verified November 2016

Efficacy, Safety and Tolerability of Multiple Doses of Valsartan in Children With Hypertension With or Without CKD

Condition:   Pediatric Hypertension With or Without CKD
Interventions:   Drug: VAL489;   Drug: VAL489 matching placebo
Sponsor:   Novartis Pharmaceuticals
Recruiting - verified November 2016

Database for Clinical and Anamnestic Data in Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:  
Sponsor:   Medical University of Graz
Recruiting - verified November 2016

Nesiritide in Resistant Hypertension

Condition:   Hypertension
Interventions:   Drug: Nesiritide (BNP);   Drug: Nesiritide (BNP);   Drug: Placebo
Sponsor:   Mayo Clinic
Terminated - verified December 2016

Bariatric Surgery, Arterial Stiffness and Target Organ Damage Study (BASTOD)

Conditions:   Hypertension;   Obesity
Intervention:   Procedure: Bariatric surgery (Roux-en-y bypass or sleeve gastrectomy)
Sponsor:   University Hospital, Montpellier
Completed - verified November 2016

A Continuous, Non-Invasive, Real-time Method for Estimating and Predicting Intracranial Hypertension

Conditions:   Intracranial Hypertension;   Elevated ICP (Intracranial Pressure)
Intervention:   Other: No Interventions
Sponsor:   University of Colorado, Denver
Active, not recruiting - verified December 2016

A Machine Learning Approach to Continuous Vital Sign Data Analysis

Condition:   Vital Signs
Intervention:  
Sponsor:   University of Colorado, Denver
Enrolling by invitation - verified December 2016

Efficacy of Ventavis Used in Real-life Setting.

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Inhaled iloprost (Ventavis, BAYQ6256)
Sponsor:   Bayer
Completed - verified November 2016

Epidemiologic Study to Evaluate the Proportion of Cardiovascular Disease Risk Factors in Korean Hypertensive Patients

Condition:   Hypertension
Intervention:   Other: Blood Sampling
Sponsor:   GlaxoSmithKline
Completed - verified November 2016

Post-authorization Safety Study of Etoricoxib and Other Anti-inflammatory Therapies in European Patients With Ankylosing Spondylitis (MK-0663-163)

Condition:   Ankylosing Spondylitis
Intervention:  
Sponsor:   Merck Sharp & Dohme Corp.
Active, not recruiting - verified November 2016

Community Glaucoma Screening Follow-up

Condition:   Glaucoma
Interventions:   Other: Voucher;   Other: Telephone Call;   Other: Contact
Sponsors:   Wills Eye;   Temple University
Completed - verified November 2016

Randomized Controlled Trial of Fetoscopic Endoluminal Tracheal Occlusion With a Balloon Versus Expectant Management During Pregnancy in Fetuses With Left Sided Congenital Diaphragmatic Hernia and Moderate Pulmonary Hypoplasia.

Conditions:   Congenital Diaphragmatic Hernia;   Fetal Surgery;   Pulmonary Hypoplasia
Intervention:   Procedure: Fetoscopic Endoluminal Tracheal Occlusion
Sponsors:   University Hospital, Gasthuisberg;   King's College Hospital NHS Trust (UK);   Hospital Clinic of Barcelona (ES);   Hôpital Antoine Béclère, Clamart (FR);   Hôpital Necker - Enfants Malades, Paris (FR);   University Hospital of Bonn, (DE);   Mater Mother's Hospital, Brisbane (AUS);   Ospedale Maggiore Policlinico, Milan (IT);   Ospedale Pediatrico Bambino Gesù, Rome (IT);   Mount Sinai Hospital, Toronto (CAN);   Baylor College of Medicine/Texas Children's Hospital (US)
Recruiting - verified December 2016

Complications in Hypertension and Obesity

Conditions:   Metabolic Syndrome;   Hypertension;   Obesity;   Dyslipidemia;   Hyperglycemia
Intervention:  
Sponsor:   Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Recruiting - verified December 2016

Photographic Imaging of the Retina and Optic Nerve Head of Glaucoma Patients and Normal Controls

Condition:   Glaucoma
Intervention:  
Sponsor:   Selim Orguel
Active, not recruiting - verified November 2016

Evaluation of Patients With Liver Disease

Conditions:   Biliary Liver Cirrhosis;   Hemochromatosis;   Hepatitis;   Hepatolenticular Degeneration;   Liver Disease
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified November 2016

Establishment of a Perinatal Database and a Bank of Biological Materials

Conditions:   Preterm Labor;   Preterm Birth;   Pregnancy
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed - verified November 2016

Bogalusa Heart Study

Conditions:   Atherosclerosis;   Cardiovascular Diseases;   Heart Diseases;   Coronary Disease;   Hypertension
Intervention:  
Sponsors:   Tulane University;   National Heart, Lung, and Blood Institute (NHLBI);   National Institute on Aging (NIA);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Environmental Health Sciences (NIEHS)
Active, not recruiting - verified December 2016

Racial Variation in ACE--Genetic and Physiologic Bases

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Hypertension
Intervention:  
Sponsors:   Vanderbilt University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified November 2016

Diagnosis of Pheochromocytoma

Condition:   Pheochromocytoma
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified November 2016

Diabetes and Heart Disease Risk in Blacks

Conditions:   Cardiovascular;   Diabetes;   Obesity;   Hypertension
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified November 2016