High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Renal Denervation for the Treatment of Hypertension: A Pilot Safety and Efficacy Study

Condition:   Hypertension
Intervention:   Device: Radio frequency renal denervation system (Golden Leaf GL-06E15A)
Sponsor:   Shanghai Golden Leaf MedTec Co. Ltd
Recruiting - verified February 2016

Double-masked Study of PG324 Ophthalmic Solution in Patients With Open-angle Glaucoma or Ocular Hypertension

Conditions:   Open-angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: PG324 Ophthalmic Solution;   Drug: Netarsudil (AR-13324) ophthalmic solution;   Drug: Latanoprost ophthalmic solution
Sponsor:   Aerie Pharmaceuticals
Not yet recruiting - verified February 2016

Serelaxin To Lower Portal Pressure

Conditions:   Liver Cirrhosis;   Hypertension, Portal
Interventions:   Drug: Serelaxin;   Drug: Placebo
Sponsors:   University of Edinburgh;   Novartis Pharmaceuticals;   NHS Lothian
Not yet recruiting - verified December 2015

Distal Renal Denervation

Condition:   Hypertension, Resistant to Conventional Therapy
Interventions:   Procedure: Distal renal denervation;   Procedure: Conventional renal denervation
Sponsor:   Federal State Budgetary Scientific Institution, Research Institute of Cardiology
Active, not recruiting - verified January 2016

Effects of Aerobic Exercise on Blood Pressure Levels of Resistant Hypertensive Subjects

Conditions:   Hypertension;   Resistant Hypertension
Intervention:   Behavioral: Aerobic Exercise Training
Sponsor:   Federal University of Paraíba
Recruiting - verified February 2016

REMODEL: Hypertensive Heart Disease

Conditions:   Left Ventricular Hypertrophy;   Hypertension;   Myocardial Fibrosis
Interventions:   Other: Cardiovascular Magnetic Resonance;   Other: Echocardiogram;   Other: Electrocardiogram;   Device: Ambulatory Blood Pressure Monitoring
Sponsor:   National Heart Centre Singapore
Recruiting - verified January 2016

A Study of Ubenimex in Patients With Pulmonary Arterial Hypertension (WHO Group 1)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: ubenimex;   Other: placebo
Sponsor:   Eiger BioPharmaceuticals
Not yet recruiting - verified January 2016

Antihypertensive Effect of Fermented Milk With Lactococcus Lactis on Prehypertensive Subjects

Condition:   Hypertension
Interventions:   Dietary Supplement: Fermented milk;   Dietary Supplement: Acidified milk
Sponsor:   Centro de Investigación en Alimentación y Desarrollo A.C.
Completed - verified February 2016

A ED-based Intervention to Improve Antihypertensive Adherence

Conditions:   Hypertensive Emergency;   Hypertension;   Blood Pressure
Interventions:   Behavioral: ED-based behavioral intervention;   Behavioral: ED usual care plus education
Sponsors:   Vanderbilt University;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified January 2016

The Influence of Circadian and Long-term Blood Pressure Variation on the Recurrent Stroke

Condition:   Stroke
Intervention:  
Sponsor:   Zhu Shi
Recruiting - verified January 2016

Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension - CATALYST

Condition:   Connective Tissue Disease-Associated Pulmonary Arterial Hypertension
Interventions:   Drug: Placebo capsules;   Drug: Bardoxolone methyl capsules
Sponsor:   Reata Pharmaceuticals, Inc.
Not yet recruiting - verified February 2016

Pre-eclampsia and Biochemical Markers

Condition:   Detection of Preeclampsia Complications
Intervention:  
Sponsor:   Assiut University
Recruiting - verified January 2016

Preventing Metabolic Side Effects of Thiazide Diuretics With KMgCitrate

Condition:   Hypertension
Interventions:   Drug: Potassium Magnesium Citrate (KMgCit);   Drug: Potassium Chloride (KCl);   Drug: Chlorthalidone
Sponsor:   University of Texas Southwestern Medical Center
Recruiting - verified January 2016

Comparison of Optic Nerve Sheath Diameter Measured by Ultrasonography Before and After Ventriculoperitoneal Shunt Surgery in Adult Patients With Hydrocephalus

Condition:   Hydrocephalus
Intervention:   Device: ultrasonographic measurement of optic nerve sheath diameter
Sponsor:   Yonsei University
Not yet recruiting - verified January 2016

Clinical Research to Explore Manifestations of Heart Failure Using Infrared Thermal Imaging Technology

Condition:   Heart Failure,Congestive
Intervention:  
Sponsor:   Jing Huang
Recruiting - verified February 2016

OCEAN Registry: Obesity and Clock for Elegant Aging Registry

Conditions:   Obesity;   Circadian Dysregulation;   Aging;   Cardiovascular Disease
Intervention:  
Sponsor:   Chang Gung Memorial Hospital
Recruiting - verified February 2016

The Trinity, Ulster and Department of Agriculture Cohort Study

Conditions:   Cardiovascular Disease;   Osteoporosis;   Alzheimer's Disease;   Hypertension
Intervention:  
Sponsors:   University of Ulster;   University of Dublin, Trinity College;   University College Cork;   University College Dublin
Active, not recruiting - verified January 2016

Evaluation of Corneal Temperature by Infrared Thermography in Glaucoma Patients

Condition:   Glaucoma
Intervention:   Device: infrared thermography
Sponsor:   University Hospital, Basel, Switzerland
Completed - verified February 2016

Evaluation of Exercise Capacity and Exercise Limitation in Patients With Pulmonary Langerhans Cell Histiocytosis

Condition:   Langerhans Cell Histiocytosis
Intervention:  
Sponsor:   InCor Heart Institute
Not yet recruiting - verified January 2016

Comparative Effectiveness of Health System vs. Multilevel Interventions to Reduce Hypertension Disparities

Condition:   Uncontrolled Hypertension
Interventions:   Behavioral: Provider Audit-Feedback;   Behavioral: Provider Audit-Feedback, Stratified by race, ethnicity, payor status;   Behavioral: Blood Pressure Measurement Standardization;   Behavioral: System Level Leadership Intervention;   Behavioral: Collaborative Care Team Intervention;   Behavioral: Community Health Worker;   Behavioral: Specialist Care
Sponsors:   Johns Hopkins University;   National Heart, Lung, and Blood Institute (NHLBI);   Mid-Atlantic Association of Community Health Centers;   Patient-Centered Outcomes Research Institute
Not yet recruiting - verified February 2016

Measuring the Impact of Dietary Supplementation With a New Baking Product on Gut Microbiota and Cholesterol Metabolism

Condition:   Hypercholesterolemia
Interventions:   Dietary Supplement: PreBIOil;   Dietary Supplement: Control
Sponsors:   Fondazione Edmund Mach;   Casa di Cura Eremo di Arco (TN) Italy;   OlioCRU Consorzio srl Arco (TN) Italy
Recruiting - verified January 2016

Norepinephrine To Prevent Hypotension After Spinal Anesthesia For Cesarean Delivery: A Dose Finding Study

Condition:   Hypotension
Interventions:   Drug: Norepinephrine;   Drug: Normal Saline
Sponsor:   Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Recruiting - verified January 2016

Metabolic Effects of Angiotensin-(1-7)

Conditions:   Obesity;   Insulin Resistance;   Hypertension;   Metabolic Cardiovascular Syndrome
Interventions:   Drug: Angiotensin-(1-7);   Drug: Saline
Sponsor:   Vanderbilt University
Recruiting - verified February 2016

Prognostic Observation of Posterior Reversible Encephalopathy Syndrome

Condition:   Posterior Reversible Encephalopathy Syndrome
Intervention:  
Sponsors:   Yantai Yuhuangding Hospital;   University of Southern California
Not yet recruiting - verified February 2016

A Study Investigating Routine Practice of Chronic Thromboembolic Pulmonary Hypertension Management in EMEA Countries

Condition:   Hypertension, Pulmonary
Intervention:   Other: Standard of care
Sponsor:   Bayer
Not yet recruiting - verified February 2016

The Relationship Between HHcy and Contrast-induced Nephropathy in Hypertensive Patients After Coronary Artery Diagnosis and Treatment

Conditions:   Homocysteine;   Coronary Disease;   Angioplasty,Balloon,Coronary;   Contrast Media;   Nephropathy;   Hypertension
Interventions:   Drug: Enalapril Maleate Tablets(as the program-based antihypertension);   Drug: Enalapril Maleate and Folic Acid tablets(as the program-based antihypertension);   Drug: Placebo
Sponsor:   Fuling Central Hospital of Chongqing City
Recruiting - verified February 2016

The Safety and Efficacy of Dapagliflozin Therapy in Combination With Insulin in Japanese Subjects With Type 1 Diabetes Mellitus (T1DM)

Condition:   Type 1 Diabetes Mellitus
Interventions:   Drug: Dapagliflozin 5 mg;   Drug: Dapagliflozin 10mg
Sponsor:   AstraZeneca
Recruiting - verified February 2016

Riociguat in Children With Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsors:   Bayer;   Merck Sharp & Dohme Corp.
Recruiting - verified January 2016

Study of Trabodenoson in Adults With Ocular Hypertension or Primary Open-angle Glaucoma

Conditions:   Primary Open-Angle Glaucoma (POAG);   Ocular Hypertension (OHT)
Interventions:   Drug: trabodenoson 4.5% BID;   Drug: trabodenoson 6.0% QD;   Drug: trabodenoson 3.0% QD;   Drug: timolol 0.5% BID;   Drug: placebo BID
Sponsor:   Inotek Pharmaceuticals Corporation
Recruiting - verified January 2016

EUS-guided Glue Injection for Varices Study

Condition:   Gastroesophageal Varices
Intervention:   Procedure: EUS-guided glue injection
Sponsor:   Chinese University of Hong Kong
Recruiting - verified January 2016

Electronic Activity Level Monitoring Pilot in Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Hypertension, Pulmonary
Intervention:   Other: Correlation assessment
Sponsor:   Bayer
Recruiting - verified February 2016

Early Vascular Adjustments During Hypertensive Pregnancy

Conditions:   Hypertension, Pregnancy-Induced;   Pre-Eclampsia
Interventions:   Drug: Labetalol;   Drug: Nifedipine;   Drug: Methyldopa
Sponsor:   Maastricht University Medical Center
Recruiting - verified February 2016

Operative Procedures vs. Endovascular Neurosurgery for Untreated Pseudotumor Trial

Conditions:   Pseudotumor Cerebri;   Idiopathic Intracranial Hypertension (IIH)
Interventions:   Procedure: Dural Venous Sinus Stenting;   Procedure: Cerebrospinal Fluid Shunting
Sponsor:   St. Joseph's Hospital and Medical Center, Phoenix
Recruiting - verified February 2016

Southwest Health Extension Partnership to Enhance Research Dissemination

Condition:   Cardiovascular Diseases
Interventions:   Other: Enhanced practice transformation support;   Other: Standard practice transformation support
Sponsors:   University of Colorado, Denver;   University of New Mexico
Recruiting - verified February 2016

Pulmonary Artery Denervation for Treatment of Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Procedure: denervation;   Procedure: sham procedure
Sponsors:   Centre Hospitalier Universitaire de Nice;   Assistance Publique Hopitaux De Marseille;   University Hospital, Toulouse;   University Hospital, Grenoble;   Assistance Publique - Hôpitaux de Paris
Active, not recruiting - verified February 2016

Vascular Effects of Mineralocorticoid Receptor Antagonism in Kidney Disease

Conditions:   Chronic Kidney Disease;   Albuminuria
Interventions:   Drug: Spironolactone;   Drug: Amiloride
Sponsor:   University of Alabama at Birmingham
Recruiting - verified January 2016

The Effects of CPAP Withdrawal on Cerebral Vascular Reactivity and Brain Oxygenation in OSA

Condition:   Sleep Apnea, Obstructive
Intervention:   Device: Continuous positive airway pressure device
Sponsor:   University of Zurich
Recruiting - verified February 2016

Clinical Trial to Evaluation the Safety and Efficacy of GR-MD-02 for the Treatment of Liver Fibrosis and Resultant Portal Hypertension in Patients With Nash Cirrhosis

Condition:   Hypertension, Portal
Interventions:   Drug: GR-MD-02;   Drug: Placebo
Sponsors:   Galectin Therapeutics Inc.;   Brooke Army Medical Center, Stephen A. Harrison, MD;   Indiana University, Naga Chalasani, MD
Recruiting - verified September 2015

A Phase 2 Exploratory Study of CS-3150 in Japanese Hypertensive Patients With Moderate Renal Impairment

Condition:   Hypertension
Intervention:   Drug: CS-3150
Sponsor:   Daiichi Sankyo Inc.
Active, not recruiting - verified January 2016

Improving Adherence and Outcomes by Artificial Intelligence-Adapted Text Messages

Condition:   Medication Non-adherence
Intervention:   Behavioral: SMS (Text messages)
Sponsors:   University of Michigan;   Agency for Healthcare Research and Quality (AHRQ)
Recruiting - verified January 2016

EMPower: Electronic Media Powering Positive Health Changes in Youth

Conditions:   Hypertension;   Prehypertension;   Overweight;   Obesity;   Hypertrophy, Left Ventricular
Interventions:   Behavioral: Electronic Media Application;   Behavioral: Standard of care education
Sponsors:   Johns Hopkins University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified February 2016

SPYRAL HTN-ON MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Recruiting - verified February 2016

SPYRAL HTN-OFF MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Recruiting - verified February 2016

Study Comparing Lutonix AV Drug Coated Balloon vs Standard Balloon for Treatment of Dysfunctional AV Fistulae

Condition:   Arteriovenous Fistula
Interventions:   Device: Lutonix DCB;   Device: Standard Balloon Angioplasty Catheter
Sponsor:   C. R. Bard
Recruiting - verified February 2016

Impact of Community Health Workers on Adherence to Therapy for Non-Communicable Chronic Disease in Chiapas, Mexico

Conditions:   Hypertension;   Diabetes Mellitus, Type 2
Intervention:  
Sponsors:   Brigham and Women's Hospital;   Harvard University
Active, not recruiting - verified February 2016

Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension

Condition:   Hypertension
Intervention:   Drug: Trimethaphan
Sponsor:   Vanderbilt University
Recruiting - verified February 2016

Blood Pressure Control of Nifedipine GITS 60mg Treatment in Chinese Hypertensive Subjects Uncontrolled on Starting-dose Mono-therapyo-therapy.

Condition:   Hypertension
Intervention:   Drug: Nifedipine(Adalat_BAY1040)
Sponsor:   Bayer
Recruiting - verified February 2016

Effect of Dexmedetomidine After Thyroidectomy

Condition:   Thyroid Tumor
Interventions:   Drug: Desflurane;   Drug: Remifentanil;   Procedure: Thyroidectomy;   Other: Vital signs;   Behavioral: Cough reflex;   Behavioral: Ramsay Sedation Scale;   Other: Extubation time and Recovery time;   Behavioral: Visual analogue scale;   Other: Postoperative bleeding;   Other: Postoperative complications;   Other: Time to remove drainage and duration of hospital staying;   Drug: Dexmedetomidine;   Drug: Normal saline
Sponsor:   Chosun University Hospital
Recruiting - verified January 2016

TIPS in Fundal Variceal Bleeding (the TFB Study)

Conditions:   Portal Hypertension;   Bleeding Gastric Varices
Intervention:   Device: Early TIPS
Sponsors:   Institut d'Investigacions Biomèdiques August Pi i Sunyer;   Hospital Clinic of Barcelona;   Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau;   Germans Trias i Pujol Hospital;   Hospital Universitario Ramon y Cajal;   Hospital del Mar
Recruiting - verified February 2016

Genetic Testing and Counseling to Reduce Diabetic Complications

Condition:   Diabetic Complication
Interventions:   Behavioral: Personalized Risk Counselling;   Other: Normal usual care
Sponsor:   Chinese University of Hong Kong
Recruiting - verified January 2016

Low Dose Calcium to Prevent Preeclampsia

Conditions:   Pre-Eclampsia;   Hypertension, Pregnancy-Induced;   Dietary Calcium Deficiency
Interventions:   Dietary Supplement: calcium;   Behavioral: Educational sessions
Sponsors:   Federal University of São Paulo;   PPSUS (Programa Pesquisa para o SUS: gestão compartilhada em saúde);   FAPEAM (Fundação de Amparo a Pesquisa do Estado do Amazonas);   Universidade Federal do Amazonas
Recruiting - verified February 2016

Natural History and Biology of Long-Term Late Effects Following Hematopoietic Cell Transplant for Childhood Hematologic Malignancies

Conditions:   Acute Lymphoblastic Leukemia/Lymphoma;   Myelodysplasia;   Acute Myelogenous Leukemia;   Juvenile Myelomonocytic Leukemia;   Chronic Myelogenous Leukemia
Intervention:  
Sponsors:   Center for International Blood and Marrow Transplant Research;   Pediatric Blood and Marrow Transplant Consortium;   National Marrow Donor Program
Recruiting - verified February 2016

Cut Your Pressure Too: The Los Angeles Barbershop Blood Pressure Study

Condition:   Hypertension
Interventions:   Behavioral: BP measurement & pharmacy;   Behavioral: BP educational materials
Sponsors:   Cedars-Sinai Medical Center;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI);   The California Endowment;   University of California, Los Angeles;   Lincy Foundation
Recruiting - verified January 2016

A Phase III Long-term Study of TAK-536TCH in Patients With Essential Hypertension

Condition:   Essential Hypertension
Intervention:   Drug: TAK-536TCH tablet, TAK-536CCB tablet, and HCTZ 12.5 mg tablet
Sponsor:   Takeda
Active, not recruiting - verified January 2016

Phase III Trial BI 695502 Plus Chemotherapy vs. Avastin® Plus Chemotherapy in Patients With Lung Cancer

Condition:   Carcinoma, Non-Small-Cell Lung
Interventions:   Drug: Chemotherapy;   Drug: BI 695502;   Drug: bevacizumab;   Drug: Chemotherapy
Sponsor:   Boehringer Ingelheim
Recruiting - verified January 2016

The SCCS Polypill Pilot Trial

Conditions:   Hypertension;   Hyperlipidemia
Intervention:   Drug: Polypill (atorvastatin, amlodipine, losartan, and hydrochlorothiazide)
Sponsor:   Vanderbilt University
Recruiting - verified February 2016

An Efficacy and Safety Study in Children 6 to Less Than 18 Years of Age With Hypertension

Condition:   Hypertension
Interventions:   Drug: Azilsartan Medoxomil;   Drug: Losartan;   Drug: Placebo for Azilsartan Medoxomil;   Drug: Placebo for Losartan
Sponsor:   Arbor Pharmaceuticals, Inc.
Recruiting - verified January 2016

SYL040012, Treatment for Open Angle Glaucoma

Conditions:   Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: 1 drop of SYL040012 (bamosiran) Dose A;   Drug: 1 drop of SYL040012 (bamosiran) Dose B;   Drug: 1 drop of SYL040012 (bamosiran) Dose C;   Drug: 1 drop of SYL040012 (bamosiran) Dose D;   Drug: 1 drop of timolol maleate
Sponsor:   Sylentis, S.A.
Completed - verified January 2016

Peripheral Arterial Insufficiency Associated With HIV/AIDS

Conditions:   Arterial Insufficiency;   Acquired Immunodeficiency Syndrome;   HIV
Intervention:   Procedure: Ankle-Brachial index
Sponsor:   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Completed - verified January 2016

Biomarker Guided Therapies in Stage A/B Heart Failure

Conditions:   Hypertension;   Diabetes;   Cardiovascular Disease
Interventions:   Drug: Carvedilol;   Drug: Spironolactone
Sponsors:   VA Office of Research and Development;   Baylor College of Medicine
Recruiting - verified January 2016

Cornell University-Micronutrient Initiative Calcium Supplementation Study

Condition:   Preeclampsia
Interventions:   Dietary Supplement: Regimen A calcium and iron/folic acid;   Dietary Supplement: Regimen B calcium and iron/folic acid
Sponsors:   Cornell University;   Kenya Ministry of Health;   University of Nairobi;   Micronutrient Initiative
Active, not recruiting - verified January 2016

Azilsartan Medoxomil (TAK-491) Compared to Placebo in Korean Adults With Hypertension

Condition:   Hypertension
Interventions:   Drug: Azilsartan medoxomil;   Drug: Azilsartan medoxomil placebo
Sponsor:   Takeda
Completed - verified February 2016

24 Week Efficacy and Safety Study of Empagliflozin (BI 10773) in Hypertensive Black/African American Patients With Type 2 Diabetes Mellitus and Hypertension

Conditions:   Diabetes Mellitus, Type 2;   Hypertension
Interventions:   Drug: Empagliflizon low dose;   Drug: placebo;   Drug: Empagliflizon high dose
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified January 2016

Study to Evaluate the Effect of Celecoxib on the Efficacy and Safety of Amlodipine in Subjects With Hypertension Requiring Antihypertensive Therapy

Condition:   Hypertension
Interventions:   Drug: Over-encapsulated 10 mg amlodipine besylate tablet;   Drug: Matched placebo capsule for over-encapsulated celecoxib capsule;   Drug: Over-encapsulated 200 mg celecoxib capsule;   Drug: Matched placebo tablet for over-encapsulated amlodipine besylate tablet
Sponsor:   Kitov Pharmaceuticals, Ltd.
Completed - verified February 2016

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease (CKD), Not on Dialysis.

Condition:   Anemia
Interventions:   Drug: Roxadustat;   Drug: Placebo
Sponsors:   AstraZeneca;   FibroGen
Active, not recruiting - verified February 2016

An Open-Label Extension Study to Evaluate the Safety of the ForSight VISION5 Product

Conditions:   Primary Open-Angle Glaucoma;   Ocular Hypertension
Intervention:   Drug: ForSight VISION5 Product
Sponsor:   ForSight Vision5, Inc.
Completed - verified February 2016

Registro Campania Salute Network on Hypertension

Condition:   Hypertension; Heart Disease, Hypertensive
Intervention:  
Sponsor:   Federico II University
Recruiting - verified February 2016

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy;   Device: Carotid stenting
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2016

Monotherapy-Controlled Study of Nifedipine Gastrointestinal Therapeutic System and Candesartan Cilexetil in Combination in Subjects With Essential Hypertension Inadequately Controlled on Candesartan Cilexetil

Condition:   Hypertension
Interventions:   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106);   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106);   Drug: Candesartan Cilexetil;   Drug: Candesartan matching placebo;   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106) 30/16mg matching placebo;   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106)
Sponsor:   Bayer
Not yet recruiting - verified February 2016

Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension

Condition:   Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Recruiting - verified January 2016

Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension

Condition:   Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Interventions:   Drug: Macitentan;   Drug: Placebo
Sponsor:   Actelion
Recruiting - verified January 2016

Randomized Trial Comparing Diltiazem and Metoprolol For Atrial Fibrillation Rate Control

Conditions:   Atrial Fibrillation;   Atrial Flutter
Interventions:   Drug: Metoprolol;   Drug: Diltiazem
Sponsor:   CAMC Health System
Recruiting - verified January 2016

Effect of Renal Transplantation on Obstructive Sleep Apnea in End Stage Renal Disease Patients (SASinTx)

Conditions:   Obstructive Sleep Apnea;   Overhydration;   End Stage Renal Disease;   Renal Transplantation
Intervention:   Procedure: Renal transplantation
Sponsor:   Centre Hospitalier Universitaire Vaudois
Recruiting - verified January 2016

A New Screening Strategy for Varices

Condition:   Liver Cirrhosis
Intervention:  
Sponsor:   Chinese University of Hong Kong
Recruiting - verified January 2016

Prevention of Metabolic Syndrome and Increased Weight Using Metformin Concurrent to Androgen Deprivation Therapy and Radiotherapy for Locally Advanced Adenocarcinoma of the Prostate

Condition:   Prostatic Neoplasm
Interventions:   Drug: Metformin;   Drug: Placebo
Sponsor:   AHS Cancer Control Alberta
Recruiting - verified January 2016

Efficacy of Remodulin in Adults With Congenital Heart Disease (ACHD) and Pulmonary Hypertension

Condition:   Congenital Heart Disease
Intervention:   Drug: Remodulin
Sponsors:   University of California, Los Angeles;   United Therapeutics
Terminated - verified January 2016

Telmisartan to Reduce AIDS-Related Fibrotic and Inflammatory Contributors (TRAFIC Study)

Condition:   HIV-1 Infection
Intervention:   Drug: Telmisartan
Sponsors:   AIDS Clinical Trials Group;   National Institute of Allergy and Infectious Diseases (NIAID)
Active, not recruiting - verified January 2016

The Effects of an Antioxidant Formulation on Ocular Blood Flow

Condition:   Primary Open Angle Glaucoma
Interventions:   Dietary Supplement: dietary supplement with antioxidants;   Dietary Supplement: Placebo
Sponsor:   ScienceBased Health
Completed - verified January 2016

Beraprost-314d Added-on to Tyvaso® (BEAT)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Beraprost Sodium 314d Modified Release Tablets;   Drug: Placebo
Sponsor:   Lung Biotechnology PBC
Recruiting - verified November 2015

An Open-label Extended Clinical Protocol of Ranibizumab to Evaluate Safety and Efficacy in Rare VEGF Driven Ocular Diseases.

Conditions:   Choroidal Neovascularization;   Macular Edema;   Glaucoma, Neovascular;   Diabetic Retinopathy
Intervention:   Drug: ranibizumab
Sponsor:   Novartis Pharmaceuticals
Active, not recruiting - verified February 2016

Efficacy/Safety Study of Valsartan and Chlorthalidone Conjugate Treatment Compared to Simple Treatment for Hypertension

Condition:   Hypertension
Interventions:   Drug: GROUP A: Valsartan plus Chlorthalidone;   Drug: GROUP B: Valsartan;   Drug: GROUP C: Chlorthalidone
Sponsor:   Farma de Colombia SA
Completed - verified March 2015

A Study in Maintenance Kidney Transplant Recipients Following Conversion to Nulojix® (Belatacept)-Based

Condition:   Kidney Transplantation
Interventions:   Drug: Belatacept;   Drug: Tacrolimus;   Drug: Cyclosporine
Sponsor:   Bristol-Myers Squibb
Recruiting - verified September 2015

Observational Description of Compliance for the Daily Ventavis Use Via the Insight Program in Class III Pulmonary Arterial Hypertension Patients

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Ventavis (Iloprost, BAYQ6256)
Sponsor:   Bayer
Active, not recruiting - verified January 2016

Evaluation of the Safety and Tolerability of Nitric Oxide (NO) Via Inhalation to Subjects With Bronchiolitis

Condition:   Bronchiolitis
Interventions:   Drug: Nitric Oxide;   Drug: Placebo
Sponsors:   Advanced Inhalation Therapies Ltd;   Soroka University Medical Center
Active, not recruiting - verified July 2015

A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn

Condition:   Pulmonary Hypertension, Familial Persistent, of the Newborn
Interventions:   Drug: placebo;   Drug: iv sildenafil
Sponsor:   Pfizer
Recruiting - verified February 2016

A Study to Evaluate Ustekinumab in Patients With Plaque Psoriasis in Asia-Pacific Countries

Condition:   Plaque Psoriasis
Intervention:   Drug: No intervention
Sponsor:   Johnson & Johnson Pte Ltd
Completed - verified January 2016

Efficacy, Safety and Tolerability of Multiple Doses of Valsartan in Children With Hypertension With or Without CKD

Condition:   Pediatric Hypertension With or Without CKD
Interventions:   Drug: VAL489;   Drug: VAL489 matching placebo
Sponsor:   Novartis Pharmaceuticals
Recruiting - verified February 2016

Blood and Cerebrospinal Fluid for Pediatric Brain Tumor Research

Condition:   Hydrocephalus
Intervention:  
Sponsor:   Ann & Robert H Lurie Children's Hospital of Chicago
Completed - verified February 2016

Gestational Diabetes Diagnostic Methods

Condition:   Gestational Diabetes
Intervention:   Behavioral: Dietary modification and medications
Sponsor:   University of Pittsburgh
Completed - verified February 2016

Interaction Between a Calcimimetic Agent and the Renin Angiotensine Aldosterone System

Condition:   Relationship Between Calcimimetic and the RAAS
Interventions:   Drug: calcimimetic agent (cinacalcet);   Drug: placebo
Sponsors:   Centre Hospitalier Universitaire Vaudois;   Swiss National Science Foundation
Completed - verified January 2016

A Study of RO5093151 in Patients With Ocular Hypertension Or Open Angle Glaucoma

Condition:   Hypertension, Glaucoma, Open-Angle
Interventions:   Drug: Placebo;   Drug: RO5093151
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

How Has Glaucoma Affected Your Quality of Life?

Conditions:   Glaucoma;   Quality of Life
Intervention:  
Sponsors:   Wills Eye;   Merck Sharp & Dohme Corp.
Active, not recruiting - verified February 2016

TRANSforming InTerprofessional Cardiovascular Prevention in Primary Care

Conditions:   Diabetes Mellitus, Type 2;   Hypertension;   Dyslipidemias;   Cholesterol, LDL;   Comorbitdity
Interventions:   Other: Facilitation;   Other: Passive diffusion (usual implementation strategy)
Sponsors:   Fonds de la Recherche en Santé du Québec;   Université de Montréal
Active, not recruiting - verified February 2016

Inhaled Iloprost in the Treatment of Patients With Pulmonary Hypertension up to 4 Years

Condition:   Pulmonary Hypertension
Intervention:   Drug: Ventavis inhaled (Iloprost, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified January 2016

Early TIPS With Polytetrafluoroethylene (PTFE) Covered Stents for High Risk Acute Variceal Bleeding in Cirrhotic Patients

Conditions:   Decompensated Cirrhosis;   Bleeding Varices
Interventions:   Procedure: Transjugular intrahepatic portosystemic shunt;   Drug: Non-selective beta blocker + Endoscopic treatment
Sponsor:   Fourth Military Medical University
Recruiting - verified February 2016

Long-term Ambrisentan Extension Study for Pediatric Patients Who Participated in AMB112529

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Ambrisentan
Sponsor:   GlaxoSmithKline
Recruiting - verified December 2015

Endothelial Function in Patients With Pulmonary Arterial Hypertension

Conditions:   Hypertension, Pulmonary;   Pulmonary Arterial Hypertension;   Pathophysiology;   Genetics
Interventions:   Device: EndoPAT measurement;   Biological: Blood Test
Sponsors:   Universitätsklinikum Hamburg-Eppendorf;   Pfizer;   Actelion
Active, not recruiting - verified January 2016

Long-Term Safety of Bimatoprost Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension

Conditions:   Glaucoma;   Ocular Hypertension
Interventions:   Drug: bimatoprost 0.01% ophthalmic solution;   Drug: bimatoprost 0.03% ophthalmic solution
Sponsor:   Allergan
Active, not recruiting - verified January 2016

The Role of a Combination of Nutraceuticals in the Control of Cardiovascular Risk

Condition:   Metabolic Syndrome
Intervention:   Drug: Armolipid Prev
Sponsor:   Federico II University
Completed - verified February 2016

Study of the Effect of Intradialytic Vasopressin on Chronic Hypertension in Patients With End Stage Renal Disease

Conditions:   Hypertension;   End Stage Renal Disease
Interventions:   Drug: Vasopressin - Very Low Dose;   Drug: Vasopressin - Low Dose;   Drug: Placebo Comparator
Sponsor:   Anjali Ganda, MD
Recruiting - verified January 2016

The Health Outcomes Management and Evaluation (HOME) Study

Conditions:   Diabetes;   Hyperlipidemia;   Heart Disease;   High Blood Pressure
Intervention:   Other: Care team
Sponsors:   Emory University;   National Institute of Mental Health (NIMH)
Completed - verified February 2016

Non Invasive Study of the Hepatic Fibrosis in Paediatrics by the Method of Study of Pediatric Hepatic Fibrosis

Conditions:   Cirrhosis;   Liver Fibrosis;   Portal Hypertension;   Cystic Fibrosis;   Cholestasis of Parenteral Nutrition
Intervention:   Other: Elastometry
Sponsor:   Assistance Publique - Hôpitaux de Paris
Active, not recruiting - verified January 2016

A Study of the Pharmacokinetics and Pharmacodynamics of MK1809 (1809-001)(COMPLETED)

Condition:   Hypertension
Interventions:   Drug: MK1809;   Drug: Comparator: Losartan;   Drug: Comparator: Placebo
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified February 2016

Genetic Mechanisms in Human Hypertension Renin-angiotensin-aldosterone System (RAAS) Inhibition Study

Condition:   Hypertension
Intervention:   Drug: Lisinopril, Atenolol
Sponsors:   Brigham and Women's Hospital;   University of Utah
Active, not recruiting - verified February 2016

Living Kidney Donor Study

Condition:   Living Kidney Donation
Intervention:  
Sponsors:   Lawson Health Research Institute;   Canadian Institutes of Health Research (CIHR)
Recruiting - verified January 2016

Study to Compare Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) in Glaucoma Patients

Condition:   Primary Open Angle Glaucoma (POAG)
Interventions:   Device: Perimetry;   Device: Confocal Scanning Laser Tomography;   Device: Optical Coherence Tomography (OCT)
Sponsors:   University Hospital Tuebingen;   Alcon Research
Active, not recruiting - verified January 2016

Open Label Access Study Of Sildenafil In Adult Patients With Pulmonary Arterial Hypertension Completing A1481244 Study

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Sildenafil citrate
Sponsor:   Pfizer
Temporarily not available - verified January 2016

Effect of CPAP on Blood Pressure in Patients With Sleep Apnea and Refractory Hypertension

Conditions:   Obstructive Sleep Apnea;   Refractory Arterial Hypertension
Interventions:   Device: CPAP;   Device: Control
Sponsors:   Corporacion Parc Tauli;   Carlos III Health Institute
Recruiting - verified February 2016

Prospective Evaluation of Blunt Renal Injury in Children

Condition:   Renal Injury
Intervention:   Other: Attenuated bedrest
Sponsors:   Children's Mercy Hospital Kansas City;   Phoenix Children's Hospital
Recruiting - verified January 2016

Indocyanine Green and Portal Pressure in Viral and Alcoholic Cirrhotic Patients With Hepatocarcinoma

Conditions:   Carcinoma, Hepatocellular;   Alcoholic Cirrhosis;   Viral Cirrhosis;   Postoperative Hepatic Failure
Intervention:  
Sponsor:   University of Lausanne Hospitals
Recruiting - verified January 2016

Doppler Ultrasound Probe for Blood Flow Detection in Severe Upper Gastrointestinal Hemorrhage

Conditions:   UGI Bleeding;   Ulcer or Variceal Hemorrhage;   Stigmata of Recent Hemorrhage;   Endoscopy;   Randomized Controlled Trials
Interventions:   Device: Doppler endoscopic ultrasound probe for blood flow detection;   Other: Standard endoscopic hemostasis
Sponsors:   VA Office of Research and Development;   UCLA Ronald Reagan Medical Center
Completed - verified January 2016

Study of Ambrisentan in Subjects With Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Drug: Ambrisentan
Sponsor:   Gilead Sciences
Active, not recruiting - verified January 2016

Effect of EGCG on the Body's Response to Insulin

Conditions:   Hypertension;   Obesity;   Type 2 Diabetes;   Insulin Resistance
Intervention:   Drug: EGCG
Sponsor:   University of Maryland
Withdrawn - verified January 2016

Effect of Aerobic Exercise on Blood Pressure Changes

Conditions:   Hypertension;   Cardiovascular Diseases
Interventions:   Behavioral: Aerobic Conditioning Program;   Behavioral: Strength Training Program
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified December 2007

Maternal and Umbilical Cord Hormone Concentrations in Twin and Singleton Pregnancies

Condition:   Normal Pregnancy
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Completed - verified January 2016

Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Biliopancreatic Diversion (BPD)- Duodenal Switch for Superobesity

Conditions:   Obesity;   Diabetes;   Hypertension
Interventions:   Procedure: Laparoscopic Biliopancreatic diversion with Duodenal switch;   Procedure: Laparoscopic Roux-en-Y Gastric Bypass
Sponsors:   Göteborg University;   Helse Sor-Ost
Active, not recruiting - verified February 2016

Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia

Conditions:   Sickle Cell Disease;   Chronic Kidney Disease;   Pulmonary Hypertension
Intervention:   Drug: Erythropoietin and Hydroxyurea
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2016

Conditioned Placebo Effects and Treatment of Hypertension

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Hypertension
Interventions:   Drug: antihypertensive drug;   Behavioral: placebo
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

Stepped Intervention for Meds Adherence and Blood Pressure Control

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Hypertension
Intervention:   Behavioral: self-medication monitoring
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

Genetic and Environmental Characteristics of Primary Pulmonary Hypertension

Conditions:   Lung Diseases;   Hypertension, Pulmonary
Intervention:  
Sponsors:   Vanderbilt University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified February 2016

Prenatal Nutrition and Adult Disease

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Diabetes Mellitus;   Diabetes Mellitus, Non-insulin Dependent;   Insulin Resistance;   Obesity;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

Pulmonary Hypertension--Mechanisms and Family Registry

Conditions:   Lung Diseases;   Hypertension, Pulmonary
Intervention:  
Sponsors:   Vanderbilt University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2016

Improving Adherence to Interventions for Hypertension

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Hypertension;   Obesity
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified July 2000

Epidemiology of Persistent Pulmonary Hypertension of the Newborn - SCOR in Lung Biology and Diseases in Infants and Children

Conditions:   Lung Diseases;   Cardiovascular Diseases;   Defect, Congenital Heart;   Heart Diseases;   Persistent Fetal Circulation Syndrome
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified October 2001

Minnesota Heart Survey - Risk Factor Survey

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Cerebrovascular Accident;   Coronary Disease;   Hypertension;   Myocardial Infarction
Intervention:  
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified February 2016

Racial Variation in ACE--Genetic and Physiologic Bases

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Hypertension
Intervention:  
Sponsors:   Vanderbilt University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2016

Diabetes and Heart Disease Risk in Blacks

Conditions:   Cardiovascular;   Diabetes;   Obesity;   Hypertension
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 2016