High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

SMS System for Patients With Uncontrolled Hypertension

Condition:   Hypertension
Intervention:   Other: SMS System
Sponsor:   Wake Forest University Health Sciences
Not yet recruiting

Strengthening Primary Healthcare Delivery for Diabetes and Hypertension in Eswatini

Conditions:   Diabetes Mellitus;   Hypertension
Interventions:   Other: PEN;   Other: ePEN
Sponsors:   University Hospital Heidelberg;   Amsterdam Institute for Global Health and Development;   Swiss Tropical & Public Health Institute;   Clinton Health Access Initiative, Nigeria;   University of Göttingen;   University of Eswatini;   SWABCHA, Eswatini;   Diabetes Swaziland
Not yet recruiting

Learning Implementation of Guideline-based Decision Support System for Hypertension Treatment (LIGHT)

Condition:   Hypertension
Intervention:   Behavioral: Computer-based decision support system
Sponsor:   China National Center for Cardiovascular Diseases
Recruiting

Non-invasive Diagnosis of Pulmonary Hypertension by Impedance Cardiography

Condition:   Pulmonary Hypertension
Intervention:   Diagnostic Test: Impedance Cardiography
Sponsor:   Medical University of Graz
Recruiting

EGD vs EUS in Diagnosing Portal Hypertension in Cirrhotic Patients.

Conditions:   Liver Cirrhoses;   Portal Hypertension
Interventions:   Diagnostic Test: Esophagogastroduodenoscopy;   Diagnostic Test: Endoscopic ultrasound
Sponsor:   Instituto Ecuatoriano de Enfermedades Digestivas
Recruiting

Inhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension

Conditions:   Sarcoidosis;   Precapillary Pulmonary Hypertension;   Interstitial Lung Disease
Intervention:   Drug: Inhaled Treprostinil
Sponsors:   University of Florida;   United Therapeutics
Not yet recruiting

Database for Clinical and Anamnestic Data in Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:  
Sponsor:   Medical University of Graz
Recruiting

Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension

Conditions:   Sickle Cell Anemia;   Pulmonary Hypertension
Interventions:   Drug: Nitric Oxide;   Device: INO Pulse - NO Delivery System
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   Mallinckrodt
Completed

Diet and Hypertension Management in African Americans With Chronic Kidney Disease

Conditions:   Chronic Kidney Diseases;   High Blood Pressure
Intervention:   Behavioral: DASH diet counseling
Sponsor:   Duke University
Recruiting

A Study for the Identification of Biomarker Signatures for Early Detection of Pulmonary Hypertension (PH)

Condition:   Hypertension, Pulmonary
Interventions:   Other: Blood Sample;   Device: ReCIVA® Breath Sampler and CASPER air supply unit
Sponsor:   Janssen Research & Development, LLC
Not yet recruiting

Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Active, not recruiting

[18F]FES PET/CT in PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: [18F] FES
Sponsor:   University of Pennsylvania
Active, not recruiting

Proper Timing of Control of Hypertension and Outcome in Acute Spontaneous Intracerebral Hemorrhage.

Conditions:   Intra Cerebral Hemorrhage;   Hypertension
Intervention:   Diagnostic Test: Modified Rankin Scale (mRS)
Sponsor:   Mansoura University Hospital
Completed

The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Paradise Renal Denervation System;   Procedure: Renal Angiogram
Sponsor:   ReCor Medical, Inc.
Recruiting

A Study of RVT-1201 in Patients With Pulmonary Arterial Hypertension (ELEVATE 1)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: RVT-1201;   Drug: Placebo
Sponsors:   Altavant Sciences GmbH;   Altavant Sciences, Inc.;   PPD
Recruiting

Impact of Multiple Doses of BAY63-2521 on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Patients With Interstitial Lung Disease (ILD) Associated Pulmonary Hypertension (PH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsor:   Bayer
Active, not recruiting

EXPEDITE: A Study of Remodulin Induction Followed by Orenitram Optimization to Treat Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Intravenous/Subcutaneous Treprostinil; Oral Treprostinil
Sponsor:   United Therapeutics
Recruiting

Sildenafil to Treat HIV-Associated Pulmonary Hypertension

Condition:   HIV
Interventions:   Procedure: MRI;   Drug: L-NMMA;   Drug: Acetylcholine
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Terminated

Portal Hypertension in Non-alcoholic Fatty Liver Disease: Association With Cardiovascular Risk and Identification of Non-invasive Biomarkers (THESIS)

Condition:   Fatty Liver Disease
Intervention:   Other: A complete cardiovascular and liver characterization will be carried out
Sponsors:   Instituto de Investigación Marqués de Valdecilla;   Hospital Universitario Puerta del Hierro Majadahonda.;   Hospital Universitario Ramón y Cajal;   Hospital General Universitario Gregorio Marañón
Not yet recruiting

Hydroxyurea in Pulmonary Arterial Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Drug: Hydroxyurea
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   The Cleveland Clinic
Withdrawn

Efficacy of Chlorthalidone and Hydrochlorothiazide Combined With Amiloride on Blood Pressure in Primary Hypertension.

Condition:   Hypertension
Interventions:   Drug: Chlorthalidone 25 mg;   Drug: Hydrochlorothiazide 50 mg;   Drug: Amiloride 20 mg;   Drug: Amiloride 10 mg
Sponsors:   Hospital de Clinicas de Porto Alegre;   Instituto de Cardiologia do Rio Grande do Sul
Recruiting

A Study to Find Out if Selexipag is Effective and Safe in Patients With Chronic Thromboembolic Pulmonary Hypertension When the Disease is Inoperable or Persistent/Recurrent After Surgery

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Interventions:   Drug: Selexipag;   Drug: Placebo
Sponsor:   Actelion
Recruiting

The Transition From Hypertension to Hypertensive Heart Disease and Heart Failure, the PREFERS Hypertension Study

Conditions:   Hypertension;   Heart Failure;   Hypertensive Heart Disease;   Diastolic Dysfunction
Intervention:  
Sponsor:   Karolinska Institutet
Enrolling by invitation

A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunction

Conditions:   Hypertension, Pulmonary;   Ventricular Dysfunction, Left
Interventions:   Drug: Riociguat (Adempas, BAY63-2521);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

ABI-009, an mTOR Inhibitor, for Patients With Severe Pulmonary Arterial Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Drug: ABI-009, nab-rapamycin, albumin-bound rapamycin
Sponsor:   Aadi, LLC
Recruiting

Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension - CATALYST

Condition:   Connective Tissue Disease-Associated Pulmonary Arterial Hypertension
Interventions:   Drug: Placebo capsules;   Drug: Bardoxolone methyl capsules
Sponsor:   Reata Pharmaceuticals, Inc.
Active, not recruiting

Estrogen Receptor Antagonist in Patients With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Fulvestrant
Sponsor:   University of Pennsylvania
Completed

Utilizing Consumer Health Informatics to Support Management of Hypertension by Clinical Pharmacists in Primary Care

Condition:   Hypertension
Intervention:   Other: BP Track
Sponsor:   University of Michigan
Active, not recruiting

Evaluation of Hypertension as a Predictor of Efficacy Bevacizumab in Metastatic Breast Cancer and Colorectal Cancer

Conditions:   Metastatic Colorectal Cancer;   Metastatic Breast Cancer
Intervention:  
Sponsors:   Spanish Breast Cancer Research Group;   Roche Farma, S.A
Completed

Non-inferiority of PRO-122 Ophthalmic Solution vs KRYTANTEK Ofteno® in Glaucoma or Ocular Hypertension (CONFORTK)

Conditions:   Primary Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: PRO-122;   Drug: Krytantek Ofteno®
Sponsor:   Laboratorios Sophia S.A de C.V.
Completed

Pediatric Primary Hypertension and the Renin-Angiotensin System (PHRAS)

Conditions:   Pediatric Disorder;   Pediatric Obesity;   Primary Hypertension
Intervention:  
Sponsor:   Wake Forest University Health Sciences
Enrolling by invitation

Economic Evaluation of Baroreceptor STIMulation for the Treatment of Resistant HyperTensioN

Condition:   Hypertension
Intervention:   Device: Baroreceptor stimulation with Barostim Neo TM
Sponsor:   Central Hospital, Nancy, France
Recruiting

Blood Pressure Monitoring in High Risk Pregnancy to Improve the Detection and Monitoring of Hypertension

Conditions:   Pregnancy, High Risk;   Pre-Eclampsia;   Hypertension;   Hypertension, Pregnancy-Induced
Intervention:   Other: Self-Monitoring of Blood Pressure
Sponsors:   University of Oxford;   King's College London;   Oxford University Hospitals NHS Trust;   University of Southampton;   University of Birmingham;   Barts & The London NHS Trust;   City, University of London;   National Institute for Health Research, United Kingdom
Active, not recruiting

A Study Investigating Routine Practice of Chronic Thromboembolic Pulmonary Hypertension Management in EMEA Countries

Condition:   Hypertension, Pulmonary
Intervention:   Other: Standard of care
Sponsor:   Bayer
Active, not recruiting

Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer

Condition:   Breast Carcinoma
Intervention:   Other: Laboratory Biomarker Analysis
Sponsor:   National Cancer Institute (NCI)
Recruiting

Long Term Safety and Efficacy of Ralinepag in Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Ralinepag
Sponsor:   United Therapeutics
Active, not recruiting

A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Macitentan;   Other: Standard-of-care
Sponsor:   Actelion
Recruiting

Screening of Pulmonary Arterial Hypertension in BMPR2 Mutation Carriers

Condition:   Pulmonary Arterial Hypertension
Intervention:  
Sponsor:   Assistance Publique - Hôpitaux de Paris
Completed

Effects of Training in Pulmonary Hypertension

Condition:   Respiratory Muscle Strength
Interventions:   Other: respiratory muscle training;   Other: sham muscle training
Sponsor:   Faculdade de Ciências Médicas da Santa Casa de São Paulo
Recruiting

Spironolactone Versus Indapamide in Obese and Hypertensive Patients

Condition:   Hypertension
Interventions:   Drug: Spironolactone;   Drug: Indapamide;   Drug: Amlodipine
Sponsors:   Peking University Third Hospital;   University of Michigan;   Peking University
Recruiting

Pulmonary Hypertension in Patients With Sickle Cell Disease in Nigeria

Conditions:   Secondary Pulmonary Arterial Hypertension;   Sickle Cell Disease;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)

Condition:   Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Interventions:   Drug: FDC macitentan/tadalafil;   Drug: Macitentan 10 mg;   Drug: Tadalafil 40 mg;   Drug: Placebo FDC;   Drug: Placebo macitentan;   Drug: Placebo tadalafil
Sponsors:   Actelion;   Covance;   Almac Clinical Technologies;   WorldCare Clinical;   Frontier Science Foundation
Recruiting

A Study to Evaluate the Effect of Latanoprostene Bunod Ophthalmic Solution 0.024% on Episcleral Venous Pressure and Outflow Facility in Participants With Ocular Hypertension

Condition:   Ocular Hypertension
Interventions:   Drug: Latanoprostene Bunod;   Drug: Placebo
Sponsor:   Bausch & Lomb Incorporated
Not yet recruiting

Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Adempas (Riociguat, BAY63-2521);   Drug: Sildenafil;   Drug: Tadalafil
Sponsor:   Bayer
Active, not recruiting

Long-term Ambrisentan Extension Study for Pediatric Patients Who Participated in AMB112529

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Ambrisentan
Sponsor:   GlaxoSmithKline
Active, not recruiting

Novel Mechanisms and Predictors of VEGF Receptor Inhibitor- or Immune Checkpoint Inhibitor-Associated Hypertension and Cardiovascular Disease

Conditions:   Renal Cell Carcinoma;   Hypertension;   Melanoma
Intervention:   Diagnostic Test: Ambulatory Blood Pressure Measurement
Sponsor:   Vanderbilt University Medical Center
Not yet recruiting

Effects of Oral Sildenafil on Mortality in Adults With PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: sildenafil citrate
Sponsor:   Pfizer
Recruiting

CXA-10 Study in Subjects With Pulmonary Arterial Hypertension

Condition:   PAH
Intervention:   Drug: CXA-10
Sponsors:   Complexa, Inc.;   Medpace, Inc.;   Innovative Analytics;   Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Recruiting

PRIMEx - A Study of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH)

Condition:   PAH
Interventions:   Drug: 75mg CXA-10;   Drug: 150mg CXA-10;   Other: Placebo
Sponsors:   Complexa, Inc.;   Medpace, Inc.;   Philips Healthcare;   Cardiovascular Clinical Science Foundation;   MicroConstants;   Innovative Analytics;   Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Recruiting

Diuretic Comparison Project

Condition:   Hypertension
Interventions:   Drug: Hydrochlorothiazide (HCTZ);   Drug: Chlorthalidone
Sponsor:   VA Office of Research and Development
Recruiting

SPYRAL HTN-ON MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Recruiting

SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Recruiting

Controlling Hypertension Through Education and Coaching in Kidney Disease

Conditions:   Chronic Kidney Diseases;   Chronic Disease;   Chronic Kidney Disease, Stage 3 (Moderate);   Chronic Kidney Disease, Stage 4 (Severe);   Chronic Kidney Disease Stage 5
Interventions:   Behavioral: Control-EDI;   Behavioral: Intervention-EDI and health coaching
Sponsors:   University of Michigan;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting

OPsumit USers Registry

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Opsumit (macitentan)
Sponsor:   Actelion
Recruiting

Multiple Chronic Conditions for Older Adults

Condition:   Chronic Disease
Interventions:   Other: Treatment as usual (TAU) + Internet;   Behavioral: TAU + ElderTree
Sponsors:   University of Wisconsin, Madison;   University of Wisconsin Hospital and Clinics (UW Health);   Medical University of South Carolina;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Effect of Dry-weight Probing Guided by Lung-Ultrasound on Ambulatory Blood Pressure and Arterial Stiffness in Hemodialysis Patients (LUST Sub-Study)

Conditions:   Chronic Kidney Disease;   Hemodialysis;   Hypertension
Interventions:   Device: Extra-vascular lung water measurements by ultrasound;   Other: Standard protocol of fluid management in hemodialysis
Sponsors:   Carmine Zoccali;   Aristotle University of Thessaloniki, Thessaloniki, Greece;   CNR-IBIM Clinical Epidemiology of Renal Diseases and Hypertension Unit, Reggio, Italy;   University Clinical Centre of Maribor, Slovenia
Completed

Astronaut Vision Issues in a Ground Analog Population: Polycystic Ovary Syndrome

Conditions:   Polycystic Ovarian Syndrome;   Idiopathic Intracranial Hypertension
Intervention:  
Sponsors:   National Aeronautics and Space Administration (NASA);   University of Texas;   Mayo Clinic;   University of Florida;   University of North Carolina;   Coastal Eye Associates
Recruiting

Relative Bioavailability Study of Marketed and Lower Dose Ambrisentan in Healthy Adult Participants

Condition:   Hypertension, Pulmonary
Interventions:   Drug: AMB new formulation (1 mg);   Drug: Reference AMB (5 mg)
Sponsor:   GlaxoSmithKline
Recruiting

Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults

Conditions:   Hypertension;   Aging
Interventions:   Drug: Nicotinamide riboside;   Other: Placebo
Sponsor:   Douglas Seals
Recruiting

RV Systolic and Diastolic Function and Contractile Reserve Under Acute Exercise and in Response to Chronic Exercise-based Rehabilitation

Conditions:   Pulmonary Hypertension;   Right Heart Failure;   Heart Failure;   Contractility;   RV-arterial Coupling
Intervention:   Other: Exercise
Sponsor:   University of Giessen
Not yet recruiting

Culturally Tailoring a Stroke Intervention in Community Senior Centers

Conditions:   Hypertension;   Stroke;   Sedentary Lifestyle;   Aged;   Minority Groups
Intervention:   Behavioral: Walking Intervention
Sponsor:   University of California, Los Angeles
Completed

GastrOesophageal Varices After Sustained Virological Response

Conditions:   Liver Diseases;   Hepatitis C
Interventions:   Diagnostic Test: Liver elastography;   Diagnostic Test: Splenic elastography;   Diagnostic Test: Gastrointestinal endoscopy
Sponsor:   Oswaldo Cruz Foundation
Recruiting

Medication Adherence in Hypertensive Individuals With Bipolar Disorder

Conditions:   Hypertension;   Bipolar Disorder
Intervention:   Behavioral: iTAB-CV
Sponsor:   Case Western Reserve University
Completed

Impact of the Reduction in Antihypertensive Treatment on Total Mortality in Frail Subjects With Low Systolic Blood Pressure: Study in Subjects Over 80 Years Living in Nursing Homes

Condition:   Hypertension
Interventions:   Other: STEP DOWN strategy;   Other: Control
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting

A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

Conditions:   PAH;   Pulmonary Hypertension;   Pulmonary Arterial Hypertension;   Hypertension;   Connective Tissue Diseases;   Familial Primary Pulmonary Hypertension;   Vascular Diseases;   Cardiovascular Diseases;   Hypertension, Pulmonary;   Lung Diseases;   Respiratory Tract Disease
Intervention:   Drug: Ralinepag
Sponsor:   United Therapeutics
Enrolling by invitation

CAndesartan vs LIsinopril Effects on the BRain

Conditions:   Hypertension;   Mild Cognitive Impairment
Interventions:   Drug: Candesartan;   Drug: Lisinopril
Sponsors:   Ihab M. Hajjar;   National Institute on Aging (NIA)
Completed

Ultrasound Elastography Assessment of Spleen and Liver Stiffness Before and After Transjugular Intrahepatic Portosystemic Shunt (TIPS) Procedure

Condition:   Portal Hypertension
Intervention:   Procedure: Transjugular Intrahepatic Portosystemic Shunt
Sponsor:   University of Kansas Medical Center
Recruiting

Investigation of a Novel Integrated Care Concept (NICC) for Patients Suffering From Chronic Cardiovascular Disease

Conditions:   Heart Failure;   Atrial Fibrillation;   Treatment Resistant Hypertension
Interventions:   Other: Novel integrated care concept (NICC);   Other: Standard care
Sponsors:   University Medical Center Rostock;   Allgemeine Ortskrankenkasse Nordost;   Techniker Krankenkasse;   Philips GmbH Market DACH;   AMEDON GmbH;   Lohfert & Lohfert AG;   Society for Network & Innovation Management of Industry (Germany);   Gemeinsamer Bundesausschuss;   Universitätsmedizin Rostock Versorgungsstrukturen GmbH
Active, not recruiting

Assessing Response to Inhaled Prostacyclin With Hyperpolarized Xe MRI

Condition:   Pulmonary Vascular Disease
Intervention:   Drug: Hyperpolarized 129Xenon gas
Sponsors:   Bastiaan Driehuys;   United Therapeutics
Recruiting

The Effect of Sodium Reduction on Blood Pressure and Physical Function in Older Adults

Conditions:   Hypertension;   Physical Disability;   Aging
Intervention:   Other: Dietary intervention
Sponsors:   Hebrew Rehabilitation Center, Boston;   Hebrew SeniorLife;   Beth Israel Deaconess Medical Center
Completed

Marinobufagenin as a Target for DIGIBIND in Preeclampsia

Condition:   Preeclampsia
Intervention:  
Sponsor:   National Institute on Aging (NIA)
Completed

Screen-and-treat Program for Chronic Kidney Disease- High Risk Persons

Condition:   Hypertension
Interventions:   Other: Screen-Educate;   Other: Screen-Educate and Intensify Treatment
Sponsor:   University of California, San Francisco
Completed

Endothelial Effects of VEGF Inhibition In Vivo in Man

Condition:   Cardiovascular Diseases
Intervention:  
Sponsors:   NHS Greater Glasgow and Clyde;   University of Glasgow
Completed

A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Conditions:   PAH;   Pulmonary Hypertension;   Pulmonary Arterial Hypertension;   Hypertension;   Connective Tissue Diseases;   Familial Primary Pulmonary Hypertension;   Vascular Diseases;   Cardiovascular Diseases;   Hypertension, Pulmonary;   Lung Diseases;   Respiratory Tract Disease
Interventions:   Drug: Ralinepag;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting

Impact of Bariatric Surgery in Obese Patients With and Without Obstructive Sleep Apnea Syndrome

Conditions:   Obesity;   Bariatric Surgery Candidate;   Apnea, Obstructive
Intervention:   Procedure: Bariatric surgery
Sponsors:   Ramsay Générale de Santé;   Dr CODRON
Recruiting

Early Detection of Progressive Kidney Disease in Preterm Infants

Conditions:   Kidney Disease;   Cardiovascular Disease
Intervention:  
Sponsor:   University of Miami
Recruiting

The Diet Gout Trial

Conditions:   Gout;   Hyperuricemia
Intervention:   Other: Subsidy for food purchases and dietitian education
Sponsors:   Johns Hopkins University;   Massachusetts General Hospital;   Beth Israel Deaconess Medical Center;   Harvard Medical School;   Rheumatology Research Foundation
Completed

Isoflavones and Peritoneal Dialysis

Condition:   Peritoneal Dialysis
Interventions:   Dietary Supplement: soy isoflavone;   Other: control
Sponsor:   National Nutrition and Food Technology Institute
Recruiting

Modified Vagus Nerve-preserving Laparoscopic Splenectomy and Azygoportal Disconnection

Conditions:   Cirrhosis;   Hypertension;   Splenectomy;   Laparoscopy
Intervention:   Procedure: Vagus nerve-preserving group
Sponsor:   Yangzhou University
Recruiting

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

Conditions:   Adrenal Gland Neoplasm;   Hypertension;   Bone Diseases, Metabolic;   Cardiovascular Disease;   Hyperinsulinemia
Intervention:  
Sponsors:   National Human Genome Research Institute (NHGRI);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

To Evaluate the Pharmacokinetic/Pharmacodynamic Interactions and Safety Between ID1801 and ID1803 in Healthy Male Adults

Conditions:   Hypertension;   Dyslipidemias
Interventions:   Combination Product: Exforge Tab;   Combination Product: Rosuzet Tab;   Combination Product: Exforge Tab + Rosuzet Tab
Sponsor:   IlDong Pharmaceutical Co Ltd
Not yet recruiting

Delayed Cord Clamping for Congenital Diaphragmatic Hernia

Condition:   Congenital Diaphragmatic Hernia
Intervention:   Procedure: DING
Sponsors:   Children's Hospital of Philadelphia;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting

Effect of Laparoscopic Sleeve Gastrectomy in the Morbidly Obese, Kidney Transplant Candidate

Conditions:   Obesity, Morbid;   Transplant; Failure, Kidney
Intervention:   Procedure: laparoscopic sleeve gastrectomy
Sponsors:   Maisonneuve-Rosemont Hospital;   Canadian surgical research fund;   Astellas Pharma Canada, Inc.
Completed

Genetics of Type 2 Diabetes in West Africans

Conditions:   Hypertension;   Diabetes
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

MRA and ARB Treatment in Screening of Primary Aldosteronism

Condition:   Primary Aldosteronism Due to Aldosterone Producing Adenoma
Interventions:   Drug: canrenone 50-100 mg orally once a day;   Drug: olmesartan 10-20 mg orally once a day
Sponsor:   University Hospital Padova
Completed

Genetics of Type 2 Diabetes Among Han Chinese

Conditions:   Diabetes;   Hypertension
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Completed

Visualization of Asymptomatic Atherosclerotic Disease for Optimum Cardiovascular Prevention

Condition:   Cardiovascular Diseases
Intervention:   Behavioral: Intervention
Sponsors:   Umeå University;   Västerbotten County Council, Sweden
Active, not recruiting

Sildenafil for the Prevention of Right Heart Failure Following LVAD Implantation

Condition:   End Stage Heart Failure
Intervention:   Drug: Sildenafil Citrate
Sponsors:   University of Calgary;   Pfizer
Recruiting

Establishment of a Perinatal Database and a Bank of Biological Materials

Conditions:   Preterm Labor;   Preterm Birth;   Pregnancy
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed

Diuretics and Volume Overload in Early CKD

Condition:   Chronic Kidney Disease
Intervention:   Drug: Diuretic initiation or augmentation
Sponsor:   VA Office of Research and Development
Not yet recruiting

Anglo-Scandinavian Cardiac Outcomes Trial: Post Trial Follow-Up Study

Conditions:   Hypertension;   Diabetes;   Death From Cardiovascular Disease;   Myocardial Infarction;   Stroke
Intervention:  
Sponsors:   Imperial College London;   Pfizer
Completed

Exploring the Mechanisms of Indoxyl Sulfate Production by Oral Tryptophan Challenge Test

Conditions:   Healthy;   Chronic Kidney Diseases
Intervention:   Dietary Supplement: Doctor's Best L-Tryptophan
Sponsor:   Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Completed

Blood Vessel Study

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   National Institute of Environmental Health Sciences (NIEHS)
Completed

Development and Evaluation of mHealth Solutions to Monitor and Involve Cardiometabolic Patients in Self-care

Conditions:   Hypertension;   Diabetes;   Dyslipidemias
Intervention:   Device: Mobile application
Sponsor:   Universidad Miguel Hernandez de Elche
Recruiting

A Targeted and Tailored Pharmacist Intervention to Improve Adherence to Antihypertensive Drugs Among Diabetes Patients

Conditions:   Diabetes Mellitus, Type 2;   Hypertension;   Medication Nonadherence
Interventions:   Behavioral: Reminders, habit-based strategies and/or involvement of family member;   Behavioral: Counselling to increase knowledge;   Behavioral: Counselling to increase motivation;   Behavioral: Explore/address other drug related problems;   Behavioral: Usual care based on the Indonesian guideline
Sponsors:   University of Groningen;   Universitas Padjadjaran
Recruiting

Tailored Home-Based Exercise Program for Multiple Chronic Conditions

Conditions:   Cancer;   Hypertension;   Diabetes
Intervention:   Other: Tailored Technology-Enhance Home-based exercise program (iHBE)
Sponsors:   Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;   National Institute of Nursing Research (NINR)
Recruiting

Effects of Propranolol on Responses to Drug-Related Imagery Scripts

Condition:   Cocaine Dependence
Interventions:   Drug: Propranolol;   Drug: Placebo
Sponsor:   National Institute on Drug Abuse (NIDA)
Terminated

Body Positioning and Pulmonary Aeration During Mechanical Ventilation

Condition:   Critical Illness
Interventions:   Device: Orthostatic board posture;   Other: Bedside sitting posture
Sponsors:   Hospital Moinhos de Vento;   Hospital Ernesto Dornelles
Not yet recruiting

Evaluation of a Health at Every Size vs a Behavioral Weight Loss Approach for Obese Women

Condition:   Obesity
Interventions:   Behavioral: Wellness-Centered (HUGS);   Behavioral: Weight-Centered (LEARN)
Sponsors:   The Reading Hospital and Medical Center;   The Edna G. Kynett Memorial Foundation
Completed

Diagnosis of Pheochromocytoma

Conditions:   Pheochromocytoma;   Endocrine Disease;   Endocrine Diseases
Interventions:   Drug: Fluorodopamine;   Drug: F-18 Fluorodopa
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Clonidine for Relapse Prevention in Buprenorphine-Maintenance Patients

Condition:   Opioid-Related Disorders
Interventions:   Drug: Clonidine;   Drug: Placebo
Sponsor:   National Institute on Drug Abuse (NIDA)
Completed

Atorvastatin Therapy to Improve Endothelial Function in Sickle Cell Disease

Condition:   Sickle Cell Disease
Interventions:   Drug: Oxypurinol;   Drug: L-NMMA;   Drug: Acetylcholine
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed

The BIomarker Guided Study for Depression

Condition:   Major Depressive Disorder
Interventions:   Drug: Guanfacine Pill;   Drug: Placebo
Sponsor:   Stanford University
Not yet recruiting

Effects of Curcumin Supplementation on Gut Barrier Function in Patients With Metabolic Syndrome

Conditions:   Obesity;   High Blood Pressure;   High Cholesterol;   Type2 Diabetes;   Heart Diseases
Intervention:   Dietary Supplement: Curcumin
Sponsor:   Virginia Commonwealth University
Recruiting

Apalutamide and Abiraterone Acetate in African American and Caucasian Men With Metastatic Castrate Resistant Prostate Cancer

Condition:   Prostate Cancer
Interventions:   Drug: ARN-509;   Drug: Abiraterone Acetate;   Drug: Prednisone
Sponsors:   Daniel George, MD;   Janssen Scientific Affairs, LLC
Recruiting

Effects of a Plant-Based Diet on Insulin Requirements and Obesity Markers in Obese Adults With T2DM.

Conditions:   Diabetes Mellitus, Type 2;   Insulin Resistance;   Obesity;   Nutritional and Metabolic Disease
Interventions:   Behavioral: DASH;   Behavioral: Whole-Food, Plant-Based
Sponsor:   University of Rochester
Not yet recruiting

Calcium Channel Blockade in Primary Aldosteronism

Conditions:   Primary Aldosteronism;   Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
Intervention:   Drug: Amlodipine
Sponsors:   Brigham and Women's Hospital;   University of Michigan
Not yet recruiting

Sleep Apnea After Extubation

Condition:   Sleep Apnea
Intervention:   Device: Respiratory polygraphy
Sponsor:   Seoul National University Hospital
Completed

Targeted CPAP Therapy for Obstructive Sleep Apnea in Pregnancy

Condition:   Obstructive Sleep Apnea
Interventions:   Device: CPAP;   Other: Pre-natal care
Sponsor:   United States Naval Medical Center, San Diego
Completed

Diagnostic and Prognostic Prediction Models for Chinese Patients With Venous Thromboembolism

Condition:   Venous Thromboembolism (VTE)
Intervention:  
Sponsors:   Ya-Wei Xu;   Nanfang Hospital of Southern Medical University;   First Affiliated Hospital, Sun Yat-Sen University
Recruiting

Long Acting Buprenorphine Injection Compared to Sublingual Buprenorphine/Naloxone Films

Condition:   Opioid Use
Interventions:   Drug: Suboxone® SL;   Drug: Sublocade®
Sponsor:   Wake Forest University Health Sciences
Not yet recruiting

End-of-life Intervention for African American Dementia Caregivers

Condition:   Encephalopathy, Ischemic
Intervention:   Behavioral: Advance Care Treatment Plan
Sponsors:   University of Illinois at Chicago;   National Institute on Aging (NIA)
Completed

Tocotrienols for Obesity of Postmenopausal Women

Conditions:   Obesity;   Postmenopausal Women
Interventions:   Drug: placebo softgel;   Drug: DeltaGold® Tocotrienol 70%
Sponsor:   Texas Tech University Health Sciences Center
Not yet recruiting

Prospective Measurement of Normal Venous Sinus Pressures

Condition:   Intracranial Venous Pressures
Intervention:   Procedure: Venogram
Sponsor:   Wake Forest University Health Sciences
Not yet recruiting

Nicotinamide Riboside Supplementation for Treating Arterial Stiffness and Elevated Systolic Blood Pressure in Patients With Moderate to Severe CKD

Conditions:   Vascular Diseases;   Kidney Disease;   Blood Pressure;   Oxidative Stress
Intervention:   Drug: Nicotinamide riboside
Sponsors:   University of Colorado, Denver;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Non-Invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129Xe Magnetic Resonance Imaging

Condition:   Pulmonary Vascular Disease
Interventions:   Drug: GE-141, Hyperpolarized 129Xenon gas;   Device: MRI
Sponsors:   Bastiaan Driehuys;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Home-base Kidney Care in Zuni Indians

Condition:   Chronic Kidney Disease
Intervention:   Other: Educational and lifestyle coaching
Sponsors:   University of New Mexico;   Zuni Tribal Administration;   Zuni comprehensive Community Health Center, Indian Health Services
Completed

Follow-up Study of Late Effects of Periconceptional Folic Acid in Mothers and Offspring in the Community Intervention Program Population: The Chinese Children and Families Study

Conditions:   Pediatric Leukemia;   Other Pediatric Cancers
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Completed

Diet for the Maintenance of Weight Loss and Metabolic Health in Obese Postmenopausal Women

Conditions:   Metabolic Syndrome;   Diet Modification;   Postmenopause
Interventions:   Other: the MED;   Other: the DASH;   Other: Control diet
Sponsor:   Poznan University of Life Sciences
Not yet recruiting

Sleep Apnea in Type 1 Diabetes

Condition:   Type 1 Diabetes, Sleep Apnea Syndrome
Interventions:   Other: Polysomnography;   Other: Evaluation of the autonomous nervous system;   Other: Clinical examination of the sleep;   Other: Clinical examination of diabetology;   Other: Biological dosages;   Other: Electrocardiogram (ECG);   Other: Carotid echography;   Other: Blood pressure
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Ministry of Health, France
Completed

Nutritional and Anti-infective Interventions for Malnutrition in Pregnancy (Beleuman Welbodi)

Conditions:   Pregnancy;   Malnutrition in Pregnancy;   Nutrition Disorders;   Stunting
Interventions:   Dietary Supplement: Ready-to-use-supplementary food;   Dietary Supplement: Corn-soy-blend;   Drug: Monthly intermittent preventive treatment of malaria during pregnancy (IPTp);   Drug: Standard intermittent preventive treatment of malaria during pregnancy (IPTp);   Other: Insecticide-treated mosquito net;   Drug: Azithromycin;   Drug: Albendazole;   Combination Product: Bacterial vaginosis testing and treatment
Sponsors:   Washington University School of Medicine;   The Children's Investment Fund Foundation
Active, not recruiting

Investigating Idiopathic Pulmonary Fibrosis in Greece (INDULGE IPF)

Condition:   Idiopathic Pulmonary Fibrosis
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Cost-effectiveness and Safety of the CADScorSystem in Patients With Symptoms Suggestive of Stable Coronary Artery Disease.

Condition:   Angina, Stable
Intervention:   Device: CADScor®System
Sponsors:   Bispebjerg Hospital;   Region Hovedstaden;   Larix A/S;   Acarix;   Kai Hansens Fond;   Kai Houmann Nielsens Fond
Recruiting

Intravenous Versus Intramuscular Administration of Methylergonovine for Uterine Contraction in Cesarean Sections

Conditions:   Uterine Atony;   Uterine Tone Disorders;   Postpartum Hemorrhage
Intervention:   Drug: Methylergonovine
Sponsor:   Johns Hopkins University
Not yet recruiting

The Effect of Intradialytic Combined Exercise on Physical Outcomes in End-Stage Renal Disease Patients

Conditions:   Kidney Failure, Chronic;   Exercise;   Physical Fitness
Interventions:   Other: Usual care with sham intervention;   Other: Intradialytic Combined Exercise
Sponsor:   Health Science Center of Xi’an Jiaotong University
Completed

Belimumab With Rituximab for Primary Membranous Nephropathy

Conditions:   Membranous Nephropathy;   MN
Interventions:   Drug: Belimumab;   Drug: Placebo for Belimumab;   Drug: Rituximab
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Immune Tolerance Network (ITN);   GlaxoSmithKline
Not yet recruiting

Prevalence of Urinary Incontinence and Evaluation of Related Factors in Patients With COPD

Conditions:   Chronic Obstructive Pulmonary Disease;   Urinary Incontinence
Intervention:  
Sponsor:   Sanko University
Recruiting

Environmental Factors and Embryonic Development Project

Conditions:   Spontaneous Abortion;   Fetal Death;   Stillbirth;   Birth Defects;   Preterm Birth;   Low Birth Weight;   Pregnancy With Medical Condition (Non-Specific);   Gestational Diabetes;   Gestational Hypertension
Intervention:   Other: No intervention
Sponsors:   Nanjing Jinling Hospital;   Peking University;   Sun Yat-sen University;   Shandong University;   Zunyi Medical University;   Zhejiang University;   Huazhong University of Science and Technology
Recruiting

Medical-economic Evaluation Comparing Intensive Outpatient Monitoring of Neuro-cardiovascular Diseases by Nurses, Doctors and Hospital and Private-sector Pharmacists, Compared to Usual Monitoring.

Conditions:   Cerebrovascular Accidents;   Myocardial Infarction
Interventions:   Other: Usual follow-up;   Other: Intensive follow-up
Sponsor:   Centre Hospitalier Universitaire Dijon
Not yet recruiting

Inflammatory Markers in Hysterectomies

Conditions:   Gynecologic Disease;   Inflammation
Intervention:  
Sponsor:   mehmet ozsurmeli
Completed

Genetic Testing to Understand and Address Renal Disease Disparities Across the United States

Condition:   Renal Disease
Intervention:   Diagnostic Test: APOL1 status
Sponsor:   Duke University
Not yet recruiting

Abdominal Obesity and Cardiovascular Risk Factors in Women Who Survived Cancer or a Related Illness Following Total Body Irradiation and Stem Cell Transplant

Conditions:   Leukemia;   Hodgkin's Lymphoma;   Non-Hodgkin's Lymphoma;   Myelodysplastic Syndrome
Intervention:   Other: Questionnaires, Laboratory tests, Abdominal MRI
Sponsors:   Memorial Sloan Kettering Cancer Center;   Queen's University, Kingston, Ontario;   Weill Medical College of Cornell University
Active, not recruiting

Reference Values for Plasma Catechols

Conditions:   Healthy Volunteers;   Normal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

The Efficacy and Safety of the Xue-Fu-Zhu-Yu Capsule in Treatment of Qi Stagnation and Blood Stasis Syndrome.

Condition:   Qi Stagnation and Blood Stasis Syndrome
Interventions:   Drug: xue-fu-zhu-yu capsule;   Drug: xue-fu-zhu-yu capsule simulated agent
Sponsors:   Guang'anmen Hospital of China Academy of Chinese Medical Sciences;   China Food and Drug Administration;   Chinese Academy of Medical Sciences
Completed

Medication Adherence Clinical Decision Support

Conditions:   Hyperlipidemias;   Hypertension;   Diabetes;   Medication Nonadherence
Interventions:   Other: Adherence-enhanced clinical decision support;   Behavioral: ReachOut Adherence intervention
Sponsors:   HealthPartners Institute;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Study of the Disease Process of Lymphangioleiomyomatosis

Conditions:   Lung Disease;   Pneumothorax;   Tuberous Sclerosis;   Lymphangioleiomyomatosis
Intervention:   Device: Toshibia Aquilion One CT
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

A Phase 1b Study Of Axitinib In Combination With Crizotinib In Patients With Advanced Solid Tumors

Condition:   Advanced Solid Tumors
Interventions:   Drug: axitinib;   Drug: crizotinib
Sponsor:   Pfizer
Completed

Diabetes and Heart Disease Risk in Blacks

Conditions:   Cardiovascular;   Diabetes;   Obesity;   Hypertension
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Assessment of Remifentanil for Rapid Sequence Induction and Intubation in Full Stomach Patient Compared to Muscle Relaxant

Condition:   Intra-tracheal Intubation
Interventions:   Drug: Remifentanil group;   Drug: neuromuscular blockade group
Sponsor:   Nantes University Hospital
Recruiting

World Trade Center Kidney-Link

Conditions:   Chronic Kidney Diseases;   Obstructive Sleep Apnea
Intervention:  
Sponsors:   Icahn School of Medicine at Mount Sinai;   Centers for Disease Control and Prevention;   National Institute for Occupational Safety and Health (NIOSH/CDC)
Recruiting

Acoustic OSA Prediction During Wakefulness and Monitoring During Sleep

Condition:   Obstructive Sleep Apnea
Intervention:  
Sponsor:   University of Manitoba
Not yet recruiting

Effect of Intravenous Administration of Mannitol on ONSD in Patients With Raised ICP

Condition:   Raised Intracranial Pressure
Interventions:   Device: Optic nerve sheath diameter measurement;   Drug: Mannitol
Sponsor:   Tribhuvan University Teaching Hospital, Institute Of Medicine.
Completed

Ocular Screening in Children and Young Adults at Risk for Increased Intracranial Pressure

Condition:   Intracranial Pressure Increase
Intervention:   Diagnostic Test: Vision/Eye screening
Sponsor:   Duke University
Recruiting

Aortic Calcification and Central Blood Pressure in Patients With Chronic Kidney Disease

Conditions:   Arterial Calcification;   Kidney Diseases;   Coronary Artery Disease;   Aortic Calcification;   Stroke;   Vascular Diseases;   Vascular Calcification
Intervention:  
Sponsor:   Central Jutland Regional Hospital
Recruiting

Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IV Head and Neck Cancer

Conditions:   Head and Neck Squamous Cell Carcinoma;   Stage IVA Oropharyngeal Carcinoma AJCC v7;   Stage IVB Oropharyngeal Carcinoma AJCC v7
Interventions:   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Fluorouracil;   Drug: Hydroxyurea;   Other: Laboratory Biomarker Analysis;   Drug: Paclitaxel;   Other: Placebo;   Radiation: Radiation Therapy;   Drug: Veliparib
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

Phase I Evaluation of Safety, Tolerability, and Pharmacokinetics for Fruquintinib in Solid Tumors

Conditions:   Advanced Solid Tumors;   Metastatic Colon Cancer
Intervention:   Drug: Fruquintinib (HMPL-013)
Sponsor:   Hutchison Medipharma Limited
Recruiting

WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study)

Conditions:   Williams Syndrome;   Cardiovascular Disease;   Multisystem Developmental Disorder;   Elastin Gene Deletion;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese Women

Conditions:   Atherosclerosis;   Diabetes Mellitus;   Obesity;   Dyslipidemia;   Hypertension
Interventions:   Behavioral: Exercise;   Behavioral: Weight Loss
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Study of ANX007 in Participants With Primary Open-angle Glaucoma

Condition:   Open Angle Glaucoma
Interventions:   Biological: 2.5mg ANX007;   Biological: 5.0mg ANX007;   Other: Sham Procedure
Sponsor:   Annexon, Inc.
Completed

CATS Tonometer IOP Reduction Latanoprost Verses Timolol

Condition:   Glaucoma; Drugs
Interventions:   Device: CATS Tonometer;   Drug: Latanoprost
Sponsor:   Intuor Technologies, Inc.
Recruiting

Macular Pigment and Visual Performance in Glaucoma Patients

Condition:   Glaucoma
Interventions:   Drug: Lutein, zeaxanthin and mesozeaxanthin;   Other: Placebo
Sponsors:   Felipe Medeiros, MD;   Heidelberg Engineering GmbH;   MacuHealth LP;   Industrial Orgánica S.A. de C.V.
Recruiting

Chart Review of XEN 45 Gel Stent: Long Term Performance and Safety Assessment (XEN LT)

Condition:   Glaucoma
Intervention:   Device: XEN Group
Sponsor:   Allergan
Completed

Dresden Glaucoma and Treatment Study (DGTS)

Conditions:   Glaucoma;   Treatment Side Effects
Intervention:  
Sponsor:   Technische Universität Dresden
Recruiting

Stop Retinal Ganglion Cell Dysfunction Study

Condition:   Glaucoma
Interventions:   Drug: Latanoprost;   Drug: Bimatoprost;   Drug: Travoprost;   Drug: Timolol;   Drug: Dorzolamide;   Drug: Brinzolamide;   Drug: Acetazolamide;   Drug: Methazolamide
Sponsors:   University of Miami;   National Eye Institute (NEI)
Recruiting

Comparing Effectiveness of the Hydrus Microstent (TM) to Two iStents to Lower IOP in Phakic Eyes

Conditions:   Primary Open Angle Glaucoma;   Pseudoexfoliative Glaucoma;   Pigmentary Glaucoma
Interventions:   Device: Hydrus Microstent;   Device: iStent Trabecular Micro Bypass
Sponsor:   Ivantis, Inc.
Completed

Treadmill Exercise and GM-CSF Study to Improving Functioning in Peripheral Artery Disease (PAD)

Condition:   Peripheral Arterial Disease
Interventions:   Behavioral: Supervised Treadmill Exercise Therapy;   Other: Health education sessions (Control);   Drug: granulocyte macrophage colony stimulating factor (GM-CSF)
Sponsors:   Northwestern University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Clinical and Molecular Studies in Families With Glaucoma and Related Diseases

Condition:   Glaucoma
Intervention:  
Sponsor:   National Eye Institute (NEI)
Completed

KW-3357 Study in Patients With Early Onset Severe Preeclampsia

Condition:   Preeclampsia
Interventions:   Drug: Antithrombin gamma;   Drug: physiological saline
Sponsors:   Kyowa Kirin Co., Ltd.;   Japan Blood Products Organization
Recruiting

Blood Collection to Validated New Therapeutics Strategies Against Preeclampsia

Condition:   Preeclampsia
Intervention:   Biological: A collection of maternal plasma and serum
Sponsors:   Assistance Publique - Hôpitaux de Paris;   INSERM UMR-S 1139
Active, not recruiting

Mixed Gel of Hydrocortisone and Aluminium Phosphate Preventing Endoscopic Submucosal Dissection Postoperative Stenosis for Patients With Large Esophageal Carcinoma

Condition:   Esophageal Stenosis Acquired
Interventions:   Other: Hydrocortisone sodium succinate mixed with Aluminium Phosphate gel (route of administration);   Other: Triamcinolone Acetonide (route of administration);   Other: Prednisone (route of administration)
Sponsor:   Peking University Third Hospital
Enrolling by invitation

Does Antibiotic Prophylaxis Reduce Wound Complications After Vulvar Excision of Premalignant Lesions

Conditions:   Premalignant Vulvar Lesion;   Benign Vulvar Lesion
Intervention:   Drug: Cefazolin
Sponsor:   Washington University School of Medicine
Recruiting

SABR for Renal Tumors

Condition:   Renal Tumor
Intervention:   Radiation: Stereotactic Ablative Radiotherapy
Sponsor:   University Health Network, Toronto
Recruiting

Liraglutide Effect in Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Drug: Liraglutide;   Other: RFM;   Drug: Anti Arrhythmics;   Procedure: Afib Catheter Ablation
Sponsor:   University of Miami
Recruiting

Angiotensin 2 Receptor (AT2R) in Endothelial Cells in Preeclampsia

Conditions:   Pre-Eclampsia;   Vascular Diseases
Intervention:   Procedure: Omental Biopsy
Sponsors:   University of Wisconsin, Madison;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Targeted Lifestyle Change Group Prenatal Care

Conditions:   Pregnancy;   Gestational Diabetes
Intervention:   Behavioral: TLC Group Prenatal Care
Sponsor:   Washington University School of Medicine
Recruiting

Safety and Efficacy Study of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-7902-006/E7080-G000-315/LEAP-006)

Condition:   Nonsquamous Non-small Cell Lung Cancer
Interventions:   Biological: Pembrolizumab;   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Pemetrexed;   Drug: Lenvatinib;   Drug: Placebo matching lenvatinib
Sponsors:   Merck Sharp & Dohme Corp.;   Eisai Inc.
Recruiting

A Safety and Efficacy Study of FCR001 vs Standard of Care in de Novo Living Donor Kidney Transplantation

Condition:   Transplanted Organ Rejection
Intervention:   Biological: FCR001
Sponsor:   Talaris Therapeutics Inc.
Recruiting

Strategies To OPpose Sugars With Non-nutritive Sweeteners Or Water (STOP Sugars NOW) Trial

Conditions:   Healthy;   Overweight and Obesity;   Metabolic Syndrome;   PreDiabetes;   Diabetes;   Overweight;   Obesity;   Dysglycemia;   Cardiovascular Diseases;   Cardiovascular Risk Factor;   Hypertension
Interventions:   Other: Sugar-sweetened beverage (SSB);   Other: Non-nutritive sweetened beverages (NSB);   Other: Water
Sponsors:   University of Toronto;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting

Myeloproliferative Neoplasms (MPNs) Patient Registry

Conditions:   Primary Myelofibrosis;   Polycythemia Vera;   Essential Thrombocythemia;   Mastocytosis;   Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative;   Leukemia, Myelomonocytic, Juvenile;   Chronic Eosinophilic Leukemia-not Otherwise Specified;   Myelodysplastic-Myeloproliferative Diseases;   Neoplasms;   Leukemia, Myelomonocytic, Chronic
Intervention:   Other: Observational
Sponsor:   University Health Network, Toronto
Recruiting

Videolaryngoscopy vs Direct Laryngoscopy for Intubation in Patients With Diabetes

Condition:   Diabetes Mellitus
Interventions:   Device: Videolaryngoscopy;   Device: Direct laryngoscopy
Sponsor:   Diskapi Teaching and Research Hospital
Completed

Sleep-disordered Breathing After Solid Organ Transplantation

Conditions:   Lung Transplantation;   Sleep-disordered Breathing
Intervention:   Other: No intervention - Diagnostic polysomnography at 1 year after lung transplantation
Sponsor:   Universitaire Ziekenhuizen Leuven
Recruiting

Roxadustat in the Treatment of Anemia in Chronic Kidney Disease (CKD) Patients, Not on Dialysis, in Comparison to Darbepoetin Alfa

Condition:   Anemia in Chronic Kidney Disease in Non-dialysis Patients
Interventions:   Drug: Roxadustat;   Drug: darbepoetin alfa
Sponsors:   Astellas Pharma Europe B.V.;   FibroGen
Completed

Effects of Behavioral Interventions on Weight Loss and Weight Maintenance

Condition:   Behavior
Intervention:   Behavioral: Behavioral interventions/modifications
Sponsor:   University of Pittsburgh
Not yet recruiting

Obstructive Sleep Apnea Among Somali-Americans

Condition:   Obstructive Sleep Apnea
Intervention:  
Sponsor:   Mayo Clinic
Recruiting

Macular Damage in Early Glaucoma and Progression

Condition:   Glaucoma
Intervention:  
Sponsors:   Columbia University;   National Eye Institute (NEI)
Recruiting

A Clinical Trial of IntensiVE Dialysis

Conditions:   Renal Replacement Therapy;   Renal Dialysis;   End Stage Kidney Disease;   End Stage Renal Disease;   Uremia
Intervention:   Procedure: haemodialysis
Sponsors:   The George Institute;   National Health and Medical Research Council, Australia;   Baxter Healthcare Corporation
Completed

The Effects of Labor Stages and Interventions on Hemodynamic Measures During & After Childbirth With Noninvasive Sensors

Conditions:   Rupture of Membranes; Premature;   Cesarean Section; Infection;   Preeclampsia
Intervention:   Device: biobeat sensor
Sponsor:   Hillel Yaffe Medical Center
Recruiting

Evaluating the Utility of Continuous Positive Airway Pressure in the Treatment of High Altitude Pulmonary Edema

Conditions:   Continuous Positive Airway Pressure;   High Altitude Pulmonary Edema
Interventions:   Device: CPAP mask system;   Drug: Nifedipine 30 MG;   Device: CPAP mask system without PEEP
Sponsors:   Centura Health;   Pulmodyne, Inc.
Not yet recruiting

Evaluation of Patients With Liver Disease

Conditions:   Biliary Liver Cirrhosis;   Hemochromatosis;   Hepatitis;   Hepatolenticular Degeneration;   Liver Disease
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

A Study To Evaluate PF-06730512 In Adults With Primary Focal Segmental Glomerulosclerosis

Condition:   Focal Segmental Glomerulosclerosis (FSGS)
Intervention:   Drug: PF-06730512
Sponsor:   Pfizer
Recruiting

The Effect of High Dose Methylprednisolone on Nailfold in Early Systemic Sclerosis ( SSc )

Conditions:   Systemic Sclerosis;   Raynaud Phenomena
Interventions:   Drug: Methylprednisolone;   Other: sodium chloride
Sponsor:   Radboud University
Recruiting

A Study in Maintenance Kidney Transplant Recipients Following Conversion to Nulojix® (Belatacept)-Based

Condition:   Kidney Transplantation
Interventions:   Drug: Belatacept;   Drug: Tacrolimus;   Drug: Cyclosporine
Sponsor:   Bristol-Myers Squibb
Active, not recruiting

A Study to Assess the Efficacy and Safety of Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)

Condition:   Duchenne Muscular Dystrophy
Interventions:   Drug: Vamorolone;   Drug: Prednisone;   Other: Placebo
Sponsors:   ReveraGen BioPharma, Inc.;   European Union;   Cooperative International Neuromuscular Research Group;   Newcastle University;   University of Pittsburgh
Recruiting

Research Study Comparing Insulin Degludec to Insulin Detemir, Together With Insulin Aspart, in Pregnant Women With Type 1 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 1
Interventions:   Drug: Insulin degludec;   Drug: Insulin Aspart;   Drug: Insulin detemir
Sponsor:   Novo Nordisk A/S
Recruiting

Consequences of Doing What Should Not be Done in Primary Care

Conditions:   Overdose;   Adverse Event
Interventions:   Drug: Benzodiazepines;   Drug: Non-steroidal anti-inflammatory drugs;   Drug: paracetamol;   Drug: Antimicrobial agent;   Drug: Lipid-lowering drug;   Diagnostic Test: Prostate cancer;   Radiation: Lumbago;   Drug: Mucolytic;   Drug: Ibuprofen and paracetamol
Sponsors:   Universidad Miguel Hernandez de Elche;   Osasunbidea;   Servicio Madrileño de Salud, Madrid, Spain;   Fondo de Investigacion Sanitaria;   AQuAS;   Agencia de Calidad Sanitaria de Andalucía;   Ministerio de Sanidad, Servicios Sociales e Igualdad;   Servicio Aragonés de Salud;   Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana;   Consellería Sanitat, Generalitat Valenciana;   MurciaSalud;   Osakidetza;   Castilla-La Mancha Health Service
Active, not recruiting

Individualized Physical Activity and Carotid Plaque Instability

Condition:   Carotid Atherosclerosis
Interventions:   Device: individualized home-based physical activity;   Other: MRI;   Biological: blood sampling;   Other: Questionnaires;   Other: 6-minute walk test
Sponsor:   Hospices Civils de Lyon
Recruiting

Acute Exercise Effects in Obese Pregnancy

Conditions:   Pregnancy Complications;   Obesity;   Pre-Eclampsia;   Gestational Diabetes
Interventions:   Behavioral: Resistance exercise;   Behavioral: Aerobic Exercise;   Behavioral: Rest
Sponsor:   Washington University School of Medicine
Recruiting

IVM Versus IVF in High Antral Follicle Count Patients

Conditions:   PCOS;   IVF;   IVM
Interventions:   Procedure: IVM;   Procedure: IVF
Sponsor:   Mỹ Đức Hospital
Completed

Phase III Study of MLN0002 (300 mg) in Treatment of Crohn's Disease

Condition:   Crohn's Disease
Interventions:   Drug: Vedolizumab;   Drug: Vedolizumab placebo
Sponsor:   Takeda
Completed

Diet Interventions in Psoriatic Arthritis

Condition:   Psoriatic Arthritis
Interventions:   Other: Diet M;   Other: Diet L
Sponsors:   University of Pennsylvania;   Women's College Hospital;   NYU Langone Health
Not yet recruiting

Targeting Obesity to Optimize Health in Cardiac Rehab (TOPCARE)

Conditions:   Obesity;   Weight Loss;   CHD - Coronary Heart Disease
Interventions:   Other: Exercise;   Behavioral: Health Education;   Other: Exercise Compliance;   Dietary Supplement: Calorie-Restricted Diet;   Behavioral: Behavioral Modification;   Other: Weight-Loss Compliance;   Other: Dietary Counseling
Sponsors:   Wake Forest University Health Sciences;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

EMPA-KIDNEY (The Study of Heart and Kidney Protection With Empagliflozin)

Condition:   Chronic Kidney Disease
Interventions:   Drug: Empagliflozin;   Drug: Matching placebo
Sponsors:   Boehringer Ingelheim;   Medical Research Council Population Health Research Unit, CTSU, University of Oxford (academic lead);   Eli Lilly and Company
Recruiting

EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)

Condition:   Heart Failure
Interventions:   Drug: Empagliflozin;   Drug: Placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting

EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)

Condition:   Heart Failure
Interventions:   Drug: Empagliflozin;   Drug: Placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting

A Study to Assess the Safety and Efficacy of Levoketoconazole in the Treatment of Endogenous Cushing's Syndrome.

Condition:   Endogenous Cushing's Syndrome
Interventions:   Drug: Levoketoconazole;   Drug: Placebo
Sponsor:   Cortendo AB
Recruiting

Healing Our Hearts Minds and Bodies: CVD Reduction in Persons With HIV

Conditions:   HIV/AIDS;   Cardiovascular Risk Factors;   Trauma, Psychological
Intervention:   Behavioral: HHMB
Sponsors:   University of California, Los Angeles;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Pazopanib Paediatric Phase II Trial Children's Oncology Group (COG) in Solid Tumors

Condition:   Solid Tumours
Intervention:   Drug: Pazopanib GW786034
Sponsors:   Novartis Pharmaceuticals;   Children's Oncology Group
Completed