High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Home Blood Pressure Study for Recent Stroke Survivors With High Blood Pressure

Conditions:   Ischemic Stroke;   Hypertension
Interventions:   Device: Home Blood Pressure Monitoring Device (Qardio Arm);   Other: Primary Care Provider Blood Pressure Management
Sponsors:   MedStar Georgetown University Hospital;   Medstar Health Research Institute
Recruiting

Efficient Self-management of Chronic Disease Using Health Information Technology - a Study on Hypertension

Conditions:   Hypertension;   High Blood Pressure
Intervention:   Other: system to support self-management of hypertension
Sponsors:   Region Skane;   the Kamprad Family Foundation;   Swedish Heart Lung Foundation;   Clinical Studies Sweden - Forum South
Active, not recruiting

Nashville - Hypertension Management Model

Condition:   Hypertension
Intervention:   Behavioral: Subjects with Hypertension
Sponsors:   Vanderbilt University Medical Center;   University of California, Los Angeles;   Cedars-Sinai Medical Center
Not yet recruiting

Effect of Exercise and Respiratory Therapy on Right Ventricular Function in Severe Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Other: Exercise and respiratory therapy
Sponsor:   Heidelberg University
Recruiting

Pediatric Pulmonary Hypertension Network (PPHNet) Informatics Registry

Conditions:   Pulmonary Vascular Disease;   Pulmonary Arterial Hypertension
Intervention:  
Sponsors:   University of Colorado, Denver;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Before-after Comparison of Pharmacist Drug Therapy Management in Pediatric Hypertension

Conditions:   Hypertension;   Blood Pressure
Intervention:   Other: Pharmacist Drug Therapy Management
Sponsors:   University of Louisiana Monroe;   Ochsner Health System
Enrolling by invitation

Comparison of Optimal Hypertension Regimens

Condition:   Hypertension
Interventions:   Drug: Amlodipine;   Drug: Lisinopril;   Drug: Amiloride;   Drug: Chlortalidone
Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   Medical Research Council
Recruiting

Treating Nocturnal Hypertension and Nocturia in African American Men

Condition:   High Blood Pressure
Interventions:   Drug: Thiazide Treatment Group;   Drug: Intensified Thiazide Treatment Group;   Drug: Combination Medication Treatment Group
Sponsor:   Cedars-Sinai Medical Center
Active, not recruiting

Hypertension and Diabetes Mellitus Community Management Center(HAD-COME) Project

Conditions:   Hypertension;   Diabetes Mellitus
Intervention:   Other: No special intervention
Sponsor:   Guangdong Provincial People's Hospital
Recruiting

Multi-provincial Cohort for Hypertension (MUCH)

Condition:   Hypertension
Interventions:   Drug: Antihypertensive Agents;   Other: Cardiovascular risk factors
Sponsors:   Beijing Institute of Heart, Lung and Blood Vessel Diseases;   Beijing Tsinghua Chang Gung Hospital;   Beijing Tiantan Hospital;   Ruijin Hospital;   Nanfang Hospital of Southern Medical University;   Southwest Hospital, China
Recruiting

The Role of Exercise Training in the Treatment of Resistant Hypertension

Condition:   Resistant Hypertension
Intervention:   Other: Exercise Group
Sponsors:   Aveiro University;   University Institute of Maia;   Cardiology Department, Hospital Infante D. Pedro, Centro Hospitalar do Baixo Vouga;   Hypertension and Cardiovascular Unit, Hospital Pedro Hispano, ULS Matosinhos;   Cintesis & Departamento de Medicina da Faculdade de Medicina do Porto
Active, not recruiting

Decompressive Cervical Surgery and Hypertension

Conditions:   Myelopathy, Compressive;   Hypertension
Intervention:   Procedure: decompressive cervical surgery
Sponsors:   Peking University First Hospital;   Peking University
Completed

Understanding the Exercise-Hypertension Paradox

Condition:   Hypertension
Interventions:   Dietary Supplement: Oral Antioxidant;   Other: Exercise rehabilitation
Sponsor:   VA Office of Research and Development
Recruiting

Dyspnea in Chronic Thromboembolic Pulmonary Hypertension

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Intervention:  
Sponsors:   Dr. Denis O'Donnell;   Queen's University
Recruiting

Riociguat in Children With Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsors:   Bayer;   Merck Sharp & Dohme Corp.
Active, not recruiting

Ertugliflozin Versus Hydrochlorothiazide in Reducing Sympathetic Neural Overactivity in Patients With Hypertension and Recently-diagnosed Type 2 Diabetes.

Conditions:   Hypertension;   Diabetes Mellitus, Type 2
Interventions:   Drug: Ertugliflozin;   Drug: Hydrochlorothiazide 12.5mg;   Device: Microneurography;   Other: SKNA recordings;   Other: Static Handgrip;   Other: Post-handgrip forearm vascular occlusion;   Other: Testing of the Arterial Baroreflex Function
Sponsors:   Cedars-Sinai Medical Center;   Merck Sharp & Dohme Corp.
Withdrawn

A Study for the Identification of Biomarker Signatures for Early Detection of Pulmonary Hypertension (PH)

Condition:   Hypertension, Pulmonary
Interventions:   Other: Blood Sample;   Device: ReCIVA® Breath Sampler and CASPER air supply unit
Sponsor:   Janssen Research & Development, LLC
Recruiting

High Blood Pressure in Paediatric Patients With Sleep Disorder Breathing.

Conditions:   Blood Pressure;   Sleep Disorder; Breathing-Related
Intervention:   Procedure: adenotonsillar surgery
Sponsors:   Fundacion del Hospital Nacional de Paraplejicos para la Investigacion y la Integracion;   Hospital General Universitario de Guadalajara;   Instituto de Investigación Hospital Universitario La Paz;   Instituto de Investigaciones del Sueño;   Fundación Jiménez Díaz;   Hospital General Universitario Santa Lucía;   Hospital Universitario de Burgos
Recruiting

Evaluation of Inhaled Iloprost Effects Using the Breelib Nebulizer, on Clinical Outcomes and Physical Activity of Patients With Advanced Pulmonary Arterial Hypertension

Condition:   Hypertension, Pulmonary
Interventions:   Drug: Iloprost (Ventavis, BAYQ6256);   Device: Breelib nebulizer
Sponsor:   Bayer
Active, not recruiting

Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Active, not recruiting

A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension

Condition:   Hypertension, Pulmonary
Interventions:   Drug: Selexipag;   Drug: Placebo
Sponsor:   Janssen Research & Development, LLC
Not yet recruiting

Prospective, Non-interventional, Multi-center, Post-authorization Safety Study of Riociguat for Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Recruiting

Continuing the Conversation: Using Narrative Communication to Support Hypertension Self-management in African American Veterans

Condition:   Hypertension
Interventions:   Behavioral: CTC Intervention;   Behavioral: Control
Sponsor:   VA Office of Research and Development
Not yet recruiting

Impact of Multiple Doses of BAY63-2521 on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Patients With Interstitial Lung Disease (ILD) Associated Pulmonary Hypertension (PH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (Adempas, BAY63-2521)
Sponsor:   Bayer
Active, not recruiting

A Study to Find Out if Selexipag is Effective and Safe in Patients With Chronic Thromboembolic Pulmonary Hypertension When the Disease is Inoperable or Persistent/Recurrent After Surgery

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Interventions:   Drug: Selexipag;   Drug: Placebo
Sponsor:   Actelion
Recruiting

Nocturnal Hypertension and Nocturia in African American Men

Condition:   Hypertension
Intervention:  
Sponsor:   Cedars-Sinai Medical Center
Completed

A Clinical Study to Find Out if Macitentan is Effective and Safe in Japanese Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH).

Condition:   Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Intervention:   Drug: macitentan 10 mg
Sponsors:   Actelion;   EPS Corporation;   Imepro Inc.;   General Laboratory, BML, Inc.;   Mitsubishi Logistics Corporation
Recruiting

Clinical Study of Inhaled GB002 for Treatment of WHO Group I Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: GB002;   Drug: Placebo;   Device: Generic Dry Powder Inhaler
Sponsor:   GB002, Inc., a wholly owned subsidiary of Gossamer Bio, Inc.
Recruiting

Treatment of Hypertension During Sleep

Conditions:   Hypertension;   Hypertension, Systolic
Intervention:   Procedure: Treatment of elevated asleep SBP mean
Sponsor:   University of Vigo
Recruiting

A Study to Evaluate ALN-AGT01 in Patients With Hypertension

Condition:   Hypertension
Interventions:   Drug: ALN-AGT01;   Drug: ALN-AGT01-Matching Placebo;   Drug: Irbesartan;   Drug: Irbesartan-Matching Placebo
Sponsor:   Alnylam Pharmaceuticals
Recruiting

A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: selexipag (Uptravi)
Sponsor:   Actelion
Recruiting

Association of Hypertensive Disorder of Pregnancy With Sleep-disordered Breathing.

Conditions:   Hypertensive Disorder of Pregnancy;   Sleep-disordered Breathing
Intervention:  
Sponsor:   The Cooper Health System
Recruiting

Amlodipine Versus Valsartan for Improvement of Diastolic Dysfunction Associated With Hypertension

Condition:   Hypertension
Interventions:   Drug: Amlodipine;   Drug: Valsartan
Sponsors:   Asan Medical Center;   Yuhan Corporation
Completed

Slow and Deep Breathing to Lower Blood Pressure in Women With Pregnancy-induced Hypertension

Condition:   Pregnancy-Induced Hypertension
Intervention:   Other: Slow and deep breathing
Sponsor:   Bournemouth University
Recruiting

Non-interventional, Postauthorization Safety Study of Ventavis for Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Ventavis (Iloprost, BAYQ6256)
Sponsor:   Bayer
Recruiting

Neurocognition, Lifestyle Modification, and Treatment Resistant Hypertension

Condition:   Treatment-Resistant Hypertension
Interventions:   Behavioral: Structured center-based lifestyle intervention;   Behavioral: Standard education and physician advice
Sponsor:   Duke University
Recruiting

Sleep Quality and Mechanisms of Cardiovascular Risks in Adults With Hypertension

Conditions:   Hypertension;   Insomnia
Intervention:   Behavioral: Cognitive Behavioral Therapy for Insomnia (CBT-I)
Sponsors:   Duke University;   National Institutes of Health (NIH)
Recruiting

Training Single Arm

Condition:   Pulmonary Hypertension
Intervention:   Other: exercise and respiratory therapy
Sponsor:   Heidelberg University
Recruiting

ACT-293987 in Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: ACT-293987
Sponsor:   Actelion
Active, not recruiting

Remodulin as Add-on Therapy for the Treatment of Persistent Pulmonary Hypertension of the Newborn

Condition:   Persistent Pulmonary Hypertension of the Newborn
Interventions:   Drug: IV Remodulin;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting

Registry of Preterm Newborns With Severe Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Preterm Infant
Intervention:  
Sponsors:   University of Colorado, Denver;   Mallinckrodt
Recruiting

MR Antagonist and STRIATIN

Conditions:   Hypertension;   Genetics Hypertension
Intervention:   Drug: Eplerenone vs Amlodipine
Sponsor:   Brigham and Women's Hospital
Recruiting

Renal Nerve Denervation in Patients With Hypertension and Paroxysmal and Persistent Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Hypertension
Interventions:   Device: Renal nerve denervation;   Device: Cryoablation
Sponsor:   Medtronic Cardiac Rhythm and Heart Failure
Recruiting

Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension

Conditions:   Glaucoma, Open-Angle;   Ocular Hypertension
Interventions:   Drug: Bimatoprost SR;   Drug: Sham Bimatoprost SR;   Procedure: Selective Laser Trabeculoplasty;   Procedure: Sham Selective Laser Trabeculoplasty
Sponsor:   Allergan
Recruiting

Phase 2 Dose-Response Study Evaluating the Safety and Efficacy of NCX 470 vs Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Conditions:   Glaucoma, Open-Angle;   Hypertension, Ocular
Interventions:   Drug: NCX 470;   Drug: Latanoprost 0.005%
Sponsor:   Nicox Ophthalmics, Inc.
Completed

Community Models for Hypertension and Diabetes Care for Refugees

Conditions:   Hypertension;   Diabetes Mellitus, Type 1;   Diabetes Mellitus, Type 2;   Comorbidities and Coexisting Conditions
Intervention:   Other: Improved Community Health Volunteer (CHV) program
Sponsors:   International Rescue Committee;   University of Southern California;   Jordan University of Science and Technology
Not yet recruiting

Moderato System: A Double-Blind Randomized Trial Ver 1.1

Conditions:   Hypertension Resistant to Conventional Therapy;   Bradycardia;   Atrioventricular Block
Interventions:   Device: PHC ON;   Device: PHC OFF
Sponsors:   BackBeat Medical Inc;   Massachusetts General Hospital;   MLM Medical Labs GmbH;   nabios GmbH
Active, not recruiting

A Long-term Extension Study of Riociguat in Patients With Symptomatic Pulmonary Arterial Hypertension.

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Adempas (Riociguat, BAY63-2521)
Sponsor:   Bayer
Recruiting

Tamoxifen Therapy to Treat Pulmonary Arterial Hypertension

Conditions:   Hypertension;   Pulmonary Arterial Hypertension;   Familial Primary Pulmonary Hypertension;   Primary Pulmonary Hypertension;   Lung Diseases;   Tamoxifen;   Estrogen Receptor Antagonist;   Hormone Antagonists;   Estrogens
Interventions:   Drug: Tamoxifen;   Drug: Placebo Oral Tablet
Sponsor:   Vanderbilt University Medical Center
Recruiting

A Cohort Study on Biomarkers of Hypertension in Guangdong Province(GDP Study)

Conditions:   Hypertension;   Cardiovascular Diseases
Intervention:   Other: Non-interventional study
Sponsor:   Guangdong Provincial People's Hospital
Recruiting

Determinants of Right Heart Remodeling in Patients With CTEPH or PAH

Condition:   Chronic Thrombo-embolic Pulmonary Hypertension and Pulmonary Arterial Hypertension
Interventions:   Radiation: magnetic resonance imaging;   Procedure: 2D and 3D trans-thoracic echocardiography;   Other: Blood samples
Sponsor:   Centre Chirurgical Marie Lannelongue
Recruiting

Mechanisms of EPO-induced Hypertension

Conditions:   Chronic Kidney Disease;   Blood Pressure;   Anemia
Intervention:   Drug: Darbepoetin
Sponsor:   VA Office of Research and Development
Not yet recruiting

Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)

Condition:   Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Interventions:   Drug: FDC macitentan/tadalafil;   Drug: Macitentan 10 mg;   Drug: Tadalafil 40 mg;   Drug: Placebo FDC;   Drug: Placebo macitentan;   Drug: Placebo tadalafil
Sponsors:   Actelion;   Covance;   Almac Clinical Technologies;   WorldCare Clinical;   Frontier Science Foundation
Recruiting

Pulmonary Arterial Hypertension Improvement With Nutrition and Exercise (PHINE)

Conditions:   Pulmonary Arterial Hypertension;   Insulin Resistance
Intervention:   Behavioral: Nutrition and Exercise
Sponsors:   The Cleveland Clinic;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum Period

Conditions:   Hypertension in Pregnancy;   Preeclampsia Severe;   Gestational Hypertension;   Postpartum Preeclampsia;   Postpartum
Interventions:   Drug: NIFEdipine ER;   Drug: Enalapril
Sponsor:   Brigham and Women's Hospital
Not yet recruiting

Giving a Low Carbohydrate Diet to Overcome Hypertension

Conditions:   Hypertension;   African Americans;   Diet, Carbohydrate-Restricted;   Risk Reduction Behavior
Interventions:   Other: Very low carbohydrate diet;   Other: Standard DPP-GLB diet;   Behavioral: Standard DPP-GLB program modules
Sponsor:   Baylor Research Institute
Not yet recruiting

Bioavailability of Hesperidine and Narirutin From Orange Juice to Identify Metabotypes in Hypertension

Conditions:   Blood Pressure;   Hypertension
Intervention:   Other: Orange juice rich in hesperidin and narirutin
Sponsor:   Technological Centre of Nutrition and Health, Spain
Not yet recruiting

Adrenal Suppression and Absorption Study of Halobetasol Propionate Foam in Subjects 12-17 With Plaque Psoriasis

Condition:   Plaque Psoriasis
Intervention:   Drug: Halobetasol Topical Foam
Sponsor:   Mayne Pharma International Pty Ltd
Completed

Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Adempas (Riociguat, BAY63-2521);   Drug: Sildenafil;   Drug: Tadalafil
Sponsor:   Bayer
Active, not recruiting

Cut Your Blood Pressure 3

Conditions:   Hypertension;   High Blood Pressure;   African American Men
Intervention:   Behavioral: Blood Pressure measurement and pharmacy
Sponsors:   Cedars-Sinai Medical Center;   Medtronic Foundation;   University of California, Los Angeles
Active, not recruiting

307B - Safety, Tolerability and Pharmacokinetics Study of TOPROL-XL® in Hypertensive Pediatric Subjects

Condition:   Hypertension
Intervention:   Drug: metoprolol succinate
Sponsor:   AstraZeneca
Completed

Efficacy, Safety, and Tolerability Study of Pirfenidone in Combination With Sildenafil in Participants With Advanced Idiopathic Pulmonary Fibrosis (IPF) and Risk of Group 3 Pulmonary Hypertension

Condition:   Idiopathic Pulmonary Fibrosis
Interventions:   Drug: Pirfenidone;   Drug: Placebo;   Drug: Sildenafil
Sponsor:   Hoffmann-La Roche
Active, not recruiting

A Study Examining the Effects of Nebivolol Compared to Atenolol on Endothelial Function

Condition:   Hypertension
Interventions:   Drug: Nebivolol;   Drug: atenolol;   Drug: placebo
Sponsors:   University of Minnesota;   Forest Laboratories
Completed

Comparison of Vasodilator Response of Inhaled Epoprostenol and Inhaled Nitric Oxide

Condition:   Pulmonary Hypertension
Interventions:   Drug: Vasodilator testing (Inhaled Nitric Oxide);   Drug: Vasodilator testing (Inhaled Epoprostenol)
Sponsor:   Brigham and Women's Hospital
Not yet recruiting

Long-Term Extension Study of Inhaled Nitric Oxide (iNO) for PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Inhaled Nitric Oxide
Sponsor:   Bellerophon Pulse Technologies
Active, not recruiting

Reprogramming Insoles In Regulating Blood Pressure In Hypertensive Subjects

Condition:   Hypertension
Intervention:   Device: Reprogramming insoles
Sponsor:   Escola Bahiana de Medicina e Saude Publica
Completed

A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Patients With PH Due to COPD

Conditions:   Pulmonary Hypertension;   Chronic Obstructive Pulmonary Disease
Interventions:   Drug: Inhaled treprostinil solution;   Drug: Placebo solution
Sponsor:   United Therapeutics
Recruiting

A Dose Escalation Study to Assess the Safety and Efficacy of Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis or Sarcoidosis

Conditions:   Pulmonary Hypertension;   Pulmonary Fibrosis;   Sarcoidosis, Pulmonary
Intervention:   Combination Product: iNO
Sponsor:   Bellerophon
Recruiting

A Dose Escalation Study to Assess the Safety and Efficacy of Pulsed iNO in Subjects With Pulmonary Fibrosis

Conditions:   Pulmonary Fibrosis;   Pulmonary Hypertension
Interventions:   Drug: iNO;   Drug: Placebo
Sponsors:   Bellerophon Pulse Technologies;   Bellerophon
Active, not recruiting

Tailored Drug Titration Using Artificial Intelligence

Condition:   Hypertension
Intervention:   Other: optima4BP
Sponsors:   Optima Integrated Health;   University of California, San Francisco
Not yet recruiting

Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

Conditions:   Obstructive Sleep Apnea of Adult;   Preeclampsia;   Obstetrical Complications
Interventions:   Device: Continuous Positive Airway Pressure;   Other: Sleep Hygiene Control
Sponsors:   The George Washington University Biostatistics Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

PeriOperative ISchemic Evaluation-3 Trial

Conditions:   Perioperative Bleeding;   Venous Thrombosis;   Arterial Thrombosis
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo (Saline);   Other: Perioperative hypotension-avoidance strategy;   Other: Perioperative hypertension-avoidance strategy
Sponsor:   Population Health Research Institute
Recruiting

Dash Cloud Digital Trial

Conditions:   Hypertension;   Health Behavior
Intervention:   Behavioral: Tracking Plus Coaching
Sponsor:   Duke University
Not yet recruiting

Effects of Vitamin D and Fish Oil on the Kidney in Hypertensives

Conditions:   Hypertension;   Kidney Diseases
Interventions:   Dietary Supplement: Vitamin D3;   Drug: Omega-3 Fatty acids;   Dietary Supplement: Vitamin D3 placebo;   Dietary Supplement: Fish oil placebo
Sponsors:   Albert Einstein College of Medicine;   Brigham and Women's Hospital;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting

Acute Effects of Vinyasa Yoga on Vascular Function

Condition:   Hypertension
Intervention:   Behavioral: Yoga session
Sponsor:   Texas State University
Completed

Evaluation of Safety and Efficacy of Brimonidine Tartrate Ophthalmic Suspension

Conditions:   Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Brimonidine Tartrate Ophthalmic Suspension;   Drug: Brimonidine Tartrate Ophthalmic Solution
Sponsor:   Sun Pharma Advanced Research Company Limited
Recruiting

Multiple Chronic Conditions for Older Adults

Condition:   Chronic Disease
Interventions:   Other: Treatment as usual (TAU) + Internet;   Behavioral: TAU + ElderTree
Sponsors:   University of Wisconsin, Madison;   University of Wisconsin Hospital and Clinics (UW Health);   Medical University of South Carolina;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Effect of a Multi-component Education Program on Salt Reduction in Adults

Conditions:   Blood Pressure;   Hypertension
Interventions:   Behavioral: Salt reduction program;   Behavioral: Healthy lifestyle program
Sponsors:   Academia Cuf Descobertas;   CUF Academic and Research Medical Center;   José de Mello Saúde;   Pingo Doce;   NOVA Medical School
Completed

The Right Ventricle in Chronic Pressure Overload: Identifying Novel Molecular Targets for Functional Imaging

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Intervention:   Procedure: Right ventricular biopsies
Sponsor:   Centre Chirurgical Marie Lannelongue
Completed

When the Kidney Reacts to Nutritional Changes

Condition:   Prehypertension
Intervention:   Other: DASH
Sponsor:   Rockefeller University
Recruiting

Relative Bioavailability Study of Marketed and Lower Dose Ambrisentan in Healthy Adult Participants

Condition:   Hypertension, Pulmonary
Interventions:   Drug: AMB new formulation (1 mg);   Drug: Reference AMB (5 mg)
Sponsor:   GlaxoSmithKline
Completed

Renal Denervation in Patients With Chronic Kidney Disease

Condition:   Chronic Kidney Disease
Intervention:   Procedure: Renal Denervation
Sponsor:   Saskatchewan Health Authority - Regina Area
Completed

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Condition:   Hypertension
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

Does Early Weight Loss Following Laparoscopic Sleeve Gastrectomy Affect Long-term Outcomes

Conditions:   Hypertension;   Diabetes Mellitus, Type 2;   Gastrostomy;   Morbid Obesity;   Weight Loss
Intervention:   Procedure: Laparoscopic sleeve gastrectomy
Sponsor:   Shaare Zedek Medical Center
Completed

Cardiovascular Disease Risk Factors in Chinese American Immigrants

Conditions:   Hypertension;   Cardiovascular Diseases;   Diabetes Mellitus;   Metabolic Syndrome X
Intervention:  
Sponsors:   Albert Einstein College of Medicine;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Effect of Home Rehabilitation on State of Patients With PAH, HFREF and IHD

Conditions:   Pulmonary Hypertension;   Heart Failure With Reduced Ejection Fraction;   Ischemic Heart Disease
Intervention:   Other: home cardiac rehabilitation and respiratory rehabilitation
Sponsor:   Medical University of Bialystok
Recruiting

Screening of Pulmonary Veino Occlusive Disease in Heterozygous EIF2AK4 Mutation Carriers

Conditions:   Mutation;   Genetic Syndrome
Intervention:   Other: Screening of adult without diagnosis of PH carrying an heterozygous EIF2AK4 mutation.
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting

Trial of Abiraterone Without Exogenous Glucocorticoids in Men With CRPC With Correlative Assessment of Hormone Intermediates.

Condition:   Castration-resistant Prostate Cancer
Interventions:   Drug: abiraterone acetate;   Drug: prednisone;   Procedure: pre-treatment and progression tumor biopsies;   Genetic: assessment of serum corticosteroid intermediates and ACTH
Sponsors:   Dana-Farber Cancer Institute;   Janssen Research & Development, LLC
Active, not recruiting

Community Health Assessment Program in the Philippines (CHAP-P)

Conditions:   Diabetes Mellitus, Type 2;   Hypertension
Intervention:   Other: CHAP-P Sessions
Sponsors:   McMaster University;   Ateneo de Zamboanga University;   Université de Montréal;   Global Alliance for Chronic Diseases (GACD);   Canadian Institutes of Health Research (CIHR);   International Development Research Centre, Canada
Active, not recruiting

Evaluating Safety of Transpulmonary Pressure Guided PEEP Management in Neurocritical Care Patients

Conditions:   Respiratory Failure;   Intracranial Hypertension
Intervention:   Device: Esophageal Balloon catheter
Sponsor:   University of North Carolina, Chapel Hill
Recruiting

Tension Tamer Randomized Control Trial

Condition:   Pre-hypertension
Interventions:   Behavioral: Tension Tamer (TT);   Behavioral: Lifestyle education program (SPCTL)
Sponsor:   Medical University of South Carolina
Completed

Prevalence of Primary Aldosteronism in Patients With Stroke

Conditions:   Primary Aldosteronism;   Stroke
Intervention:   Diagnostic Test: Aldosterone renin ratio
Sponsor:   Changi General Hospital
Recruiting

Collection of Samples From Pregnant Women for the Evaluation of Preeclampsia (Pre-E) Biomarkers

Conditions:   Preeclampsia;   Hypertension;   Proteinuria;   Thrombocytopenia;   Renal Insufficiency;   Impaired Liver Function;   Pulmonary Edema
Intervention:  
Sponsor:   Progenity, Inc.
Recruiting

Prehab for Cancer Surgery

Conditions:   Surgical Oncology;   Preoperative Care
Intervention:   Behavioral: Exercise, nutritional optimization, and psychoeducation
Sponsors:   University of Toronto;   University Health Network, Toronto;   MSH-UHN AMO Innovation Fund
Recruiting

Home Blood Pressure Monitoring Registration Study in the Elderly(HOME Study)

Condition:   Blood Pressure
Intervention:   Other: no intervention
Sponsor:   Guangdong Provincial People's Hospital
Recruiting

Modified Vagus Nerve-preserving Laparoscopic Splenectomy and Azygoportal Disconnection

Conditions:   Cirrhosis;   Hypertension;   Splenectomy;   Laparoscopy
Intervention:   Procedure: Vagus nerve-preserving group
Sponsor:   Yangzhou University
Completed

Peking University Birth Cohort in Tongzhou

Conditions:   Health Problems in Pregnancy;   Pregnancy Outcomes;   Gestational Diabetes;   Gestational Hypertension;   Preterm Birth;   Obesity;   Mother-Infant Interaction;   Child Development;   Anemia
Intervention:   Other: No intervention
Sponsors:   Peking University;   National Natural Science Foundation of China
Recruiting

Fit After Baby: A Health Intervention to Increase Postpartum Weight Loss in Women at Increased Risk for Cardiometabolic Disease

Conditions:   Cardiovascular Diseases;   Diabetes;   Gestational Diabetes;   Preeclampsia;   Gestational Hypertension;   Small for Gestational Age at Delivery;   Preterm Birth;   Overweight and Obesity
Interventions:   Behavioral: Fit After Baby;   Behavioral: Text4Baby Control Group
Sponsor:   University of Colorado, Denver
Recruiting

Automated Measurement of Optic Nerve Sheath Diameter

Conditions:   Traumatic Brain Injury;   Acute Brain Injuries;   Intracranial Hypertension
Intervention:   Device: Optic nerve ultrasound
Sponsors:   University of Michigan;   Don Massey Foundation
Completed

CAPO: Continuous Glucose Monitoring in A2 Gestational Diabetes and Pregnancy Outcomes

Conditions:   Gestational Diabetes;   Maternal Complication of Pregnancy
Interventions:   Device: Continuous Glucose Monitor;   Other: Routine Care
Sponsor:   Yale University
Not yet recruiting

Prospective Multicenter Study on the Identification of Genetic Abnormalities Predisposing to Vasospasm From a Privileged Model: the Primary Raynaud's Phenomenon

Conditions:   Primary Raynaud's Phenomenon (PR);   Genetic Mutations Causing PR;   Study of Patients and Their Relatives (With or Without Primary PR)
Intervention:   Genetic: Demonstration of genetic mutations causing Raynaud's phenomenon
Sponsor:   Nantes University Hospital
Recruiting

A Research Study to Show Aprocitentan is Efficacious and Safe to Treat Patients With Uncontrolled Blood Pressure and Chronic Kidney Disease.

Conditions:   Hypertension;   Renal Insufficiency, Chronic
Interventions:   Drug: Aprocitentan 25 mg;   Drug: Placebo
Sponsors:   Idorsia Pharmaceuticals Ltd.;   Janssen Biotech, Inc.
Withdrawn

Delayed Cord Clamping for Congenital Diaphragmatic Hernia

Condition:   Congenital Diaphragmatic Hernia
Intervention:   Procedure: DING
Sponsors:   Children's Hospital of Philadelphia;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed

Home-Based Screening for Early Detection of Atrial Fibrillation in Primary Care Patients Aged 75 Years and Older

Conditions:   Atrial Fibrillation;   Hypertension
Intervention:   Device: Screening: Intervention - Atrial fibrillation screening (ZIO XT ECG monitor, Watch-BP)
Sponsors:   Population Health Research Institute;   Canadian Stroke Prevention Intervention Network;   Canadian Institutes of Health Research (CIHR);   Heart and Stroke Foundation of Canada;   Canadian Stroke Network;   iRhythm Technologies, Inc.;   Microlife;   University of Leipzig;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)
Active, not recruiting

Podocyturia as Predictive Factor for Pre-eclampsia

Condition:   Pre-Eclampsia
Intervention:   Other: Podocyturia quantification
Sponsor:   Hospices Civils de Lyon
Recruiting

Atrial Fibrillation Detected by Continuous ECG Monitoring

Conditions:   Atrial Fibrillation;   Stroke;   Hypertension;   Diabetes
Intervention:   Device: Implantable loop recorder (Medtronic Reveal LINQ(TM))
Sponsors:   Rigshospitalet, Denmark;   Bispebjerg Hospital;   Zealand University Hospital;   Odense University Hospital;   University of Southern Denmark;   Aalborg University
Active, not recruiting

Therapeutic Contact Lens Drug Delivery System (TCL-DDS) in Patients With Recurrent Cystoid Macular Edema

Condition:   Cystoid Macular Edema
Intervention:   Drug: Dexamethasone
Sponsor:   Massachusetts Eye and Ear Infirmary
Not yet recruiting

A Comparative Study of Glidescope Versus Macintosh Laryngoscope in Adult Hypertensive Patients

Condition:   Hypertensive Patients
Interventions:   Device: Glidescope;   Device: Macintosh
Sponsor:   Mansoura University
Active, not recruiting

Prostate Artery Embolization Compared to Holmium Laser Enucleation of the Prostate for Benign Prostatic Hyperplasia

Condition:   Benign Prostatic Hyperplasia
Interventions:   Device: Holmium laser enucleation of the prostate;   Procedure: Artery embolization of the prostate
Sponsor:   Germans Trias i Pujol Hospital
Not yet recruiting

Single-anastomosis Duodeno Ileal Bypass (SADI) Versus Roux-en-Y Gastric Bypass

Condition:   Obesity, Morbid
Interventions:   Procedure: SADI-S;   Procedure: RYGB
Sponsor:   Hospices Civils de Lyon
Recruiting

Evaluation of Myocardial Sympathetic Denervation in Parkinson's Disease Using [18F]FDOPA

Condition:   Parkinson
Interventions:   Other: [18F]-DOPA;   Device: PET-CT
Sponsor:   Tel-Aviv Sourasky Medical Center
Recruiting

MyPADMGT Support of Out-Patients With Peripheral Arterial Disease

Condition:   Peripheral Arterial Disease
Interventions:   Device: MyPADMGT;   Device: MyPADMGT + Nudging
Sponsor:   McMaster University
Not yet recruiting

Rural Lifestyle Eating and Activity Program (Rural LEAP)

Condition:   Obesity
Interventions:   Behavioral: Lifestyle intervention;   Behavioral: Health education control;   Behavioral: Individual;   Behavioral: All Groups
Sponsors:   University of Florida;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Ability of Pupillometry to Reduce Sufentanil Consumption in Planned Cardiac Surgery: Randomized, Controlled, Single-center Clinical Superiority Trial

Conditions:   Patients Undergoing Cardiac Surgery;   Patients With Coronary Artery Bypass Surgery With CEC
Interventions:   Drug: Induction and maintenance of anesthesia;   Drug: Adaptation of sufentanil doses according to the usual protocol;   Drug: Adjustment of sufentanil doses according to pupillometry
Sponsor:   Centre Hospitalier Universitaire Dijon
Completed

Dyslipidemia Prevalence, Perception, Treatment, and Awareness in the Tunisian Population

Conditions:   Dyslipidemias;   Atherosclerosis;   Households;   Survey, Family Life
Intervention:  
Sponsors:   Association Tunisienne d'Etude & de Recherche sur l'Athérosclérose;   Biochimie Clinique LR99ES11;   Department of Biochemistry, La Rabta Hospital, Tunisia.;   Ministry of Health, Tunisia;   Ministry of Interior, Tunisia;   Direction des Soins de Santé de Base;   National Institute of Statistics;   National Institute of Public Health of Tunisia;   Dacima Consulting
Completed

Effect of Dexmedetomidine in Preventing Cough and Postoperative Pain After Laryngeal Surgery for Cancer

Condition:   Laryngectomy; Status
Interventions:   Drug: Dexmedetomidine Injectable Product;   Drug: Midazolam injection
Sponsor:   Eye & ENT Hospital of Fudan University
Enrolling by invitation

Different Modalities of Analgesia in Open Heart Surgeries in Mansoura University

Conditions:   Coronary Artery Disease;   Valve Disease, Heart;   Pain, Acute;   Pain, Postoperative
Interventions:   Drug: Fentanyl;   Drug: Fentanyl, Propofol;   Drug: Dexmedetomidine, Ketamine, Magnesium sulfate
Sponsor:   Mansoura University
Recruiting

User Testing and Feedback for a Mobile Health Program for Postpartum Women: A Pilot Study

Conditions:   Gestational Diabetes Mellitus;   Preeclampsia;   Gestational Hypertension;   Pre-term Delivery;   Delivery of Small for Gestational Age (SGA) Baby
Intervention:  
Sponsor:   University of Colorado, Denver
Active, not recruiting

The Role of Minerelocorticoid Receptor on Modulating Aldosterone Production

Condition:   Healthy Volunteers
Interventions:   Drug: Placebo;   Drug: Fludrocortisone;   Drug: Eplerenone
Sponsor:   Brigham and Women's Hospital
Completed

Prevalence of Obstructive Sleep Apnea Syndrome in Type 1 Diabetic Patients Treated With Insulin Pump (At1Home)

Condition:   Type 1 Diabetes
Intervention:   Other: Diagnosis of sleep apnea by oxymetry
Sponsors:   University Hospital, Grenoble;   Vitalaire;   ResMed
Recruiting

Prospective Clinical Trial of HIV+ Living Donor Kidney Donation for HIV+ Recipients

Condition:   HIV Infections
Intervention:  
Sponsor:   Johns Hopkins University
Recruiting

Inflammation, Diabetes, Ethnicity and Obesity Cohort

Conditions:   Obesity;   Diabetes Mellitus
Intervention:  
Sponsors:   University of California, San Francisco;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Comparison of Complete Decongestive Therapy With Intermittent Pneumatic Compression for Treatment of Lipedema

Condition:   Lipedema
Interventions:   Combination Product: Combined decongestive treatment (CDT) & Combined exercise;   Combination Product: Intermittent pneumatic compression & Combined exercise;   Combination Product: Combined exercise
Sponsor:   Hitit University
Completed

Tocotrienols for Obesity of Postmenopausal Women

Conditions:   Obesity;   Postmenopausal Women
Interventions:   Drug: placebo softgel;   Drug: DeltaGold® Tocotrienol 70%
Sponsor:   Texas Tech University Health Sciences Center
Recruiting

Impact of Probiotics on Weight Control and Body Composition in Overweight and Obese Individuals

Condition:   Obesity
Interventions:   Dietary Supplement: Probiotics;   Dietary Supplement: Placebo
Sponsors:   University of Manitoba;   Lallemand Health Solutions
Completed

Prospective Measurement of Normal Venous Sinus Pressures

Condition:   Intracranial Venous Pressures
Intervention:   Procedure: Venogram
Sponsor:   Wake Forest University Health Sciences
Recruiting

Neurotronic Ablation of Arteries for the Treatment of Type 2 Diabetes Mellitus and Its Comorbidities

Condition:   Type 2 Diabetes Mellitus With Circulatory Complciation
Intervention:   Device: The Neurotronic arterial ablation catheter
Sponsors:   Neurotronic, Inc.;   Libra Medical
Recruiting

Furosemide Alone or Unexpectedly With Solution of Hypertonic Saline in Nephrotic Syndrome

Condition:   Nephrotic Syndrome
Interventions:   Drug: Hypertonic saline;   Drug: Furosemide Injection
Sponsor:   Medical University of Bialystok
Recruiting

Retrospective Study of Patients Undergoing Percutaneous Intervention of the Transplant Renal Artery Stenosis

Condition:   Transplant Renal Artery Stenosis
Intervention:  
Sponsor:   Adriano Henrique Pereira Barbosa
Completed

The Acute and Chronic Effects of a Heel Raise Programme on Central Blood Pressure, Arterial Compliance and Oxygen Perfusion After Stroke

Condition:   Stroke
Intervention:   Behavioral: Heel raise intervention
Sponsor:   University of Winchester
Completed

The Reproductive Microbiome & Perinatal Health Outcomes

Conditions:   Human Microbiota;   PreTerm Birth;   Human Gastrointestinal Microbiota;   Metabolomics
Intervention:   Other: Survey, Sample collection
Sponsors:   Baylor Research Institute;   Discovery Foundation
Terminated

Collection of Whole Blood Samples for the Evaluation of Preeclampsia (Pre-E) Biomarkers From Pregnant Women

Conditions:   Pre-Eclampsia;   Hypertension;   Proteinuria in Pregnancy;   Thrombocytopenia;   Renal Insufficiency;   Impaired Liver Function;   Pulmonary Edema;   Headache;   Visual Impairment
Intervention:   Other: Non-interventional study
Sponsor:   Progenity, Inc.
Active, not recruiting

Study Evaluating Efficacy and Safety of Crisaborole in Adults With Stasis Dermatitis

Condition:   Stasis Dermatitis
Interventions:   Drug: crisaborole ointment;   Other: vehicle ointment
Sponsor:   Pfizer
Not yet recruiting

Ciclosporin A Preconditioning for Renal Artery Stenosis

Condition:   Renal Artery Stenosis
Interventions:   Drug: Ciclosporin A preconditioning before renal artery stenosis dilation;   Drug: NaCl preconditioning before renal artery stenosis dilation
Sponsor:   Hospices Civils de Lyon
Recruiting

Promote Weight Loss in Obese Peripheral Artery Disease (PAD) Patients to Prevent Mobility Loss

Conditions:   Peripheral Artery Disease;   Overweight or Obesity
Interventions:   Behavioral: Weight loss;   Behavioral: Exercise
Sponsors:   Northwestern University;   National Heart, Lung, and Blood Institute (NHLBI);   Wake Forest University
Not yet recruiting

Oral Propranolol for Prevention of Threshold Retinopathy of Prematurity

Condition:   Retinopathy of Prematurity
Interventions:   Drug: Propranolol;   Drug: Placebo
Sponsors:   Charite University, Berlin, Germany;   Ankara University;   University Hospital, Zürich;   Hadassah Medical Organization
Not yet recruiting

AOP2014 vs. BAT in Patients With Polycythemia Vera Who Previously Participated in the PROUD-PV Study.

Condition:   Polycythemia Vera
Interventions:   Drug: Pegylated-Proline-interferon alpha-2b;   Drug: Best available therapy (BAT)
Sponsors:   AOP Orphan Pharmaceuticals AG;   PharmaEssentia (Co-Sponsor for USA)
Active, not recruiting

Belimumab With Rituximab for Primary Membranous Nephropathy

Conditions:   Membranous Nephropathy;   MN
Interventions:   Drug: Belimumab;   Drug: Placebo for Belimumab;   Drug: Rituximab
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Immune Tolerance Network (ITN);   GlaxoSmithKline
Recruiting

Early Rivaroxaban for Acute Ischemic Stroke or TIA Patients With Atrial Fibrillation

Conditions:   Cerebral Infarction;   TIA
Intervention:   Drug: Rivaroxaban
Sponsor:   General Hospital of Shenyang Military Region
Recruiting

Renohemodynamic Effects of Combined empagliflOzin and LosARtan

Conditions:   Diabetes Mellitus, Type 2;   Diabetic Kidney Disease
Interventions:   Drug: Empagliflozin 10 MG;   Drug: Losartan 50Mg Tab;   Other: Placebo
Sponsor:   VU University Medical Center
Not yet recruiting

Use of Autologous Stem/Stromal Cells In Chronic Lung Disorders: Obstructive (COPD) & Restrictive (RLD)

Conditions:   COPD;   Respiratory Insufficiency
Interventions:   Procedure: Lipoaspiration;   Procedure: AD-cSVF;   Procedure: Normal Saline IV
Sponsors:   Healeon Medical Inc;   Robert W. Alexander, MD
Recruiting

Effects of Allopurinol on Inflammation and Ultrasonographic Changes in People With Elevated Uric Acid But no Symptoms

Conditions:   Musculoskeletal Degeneration;   Inflammation;   Hyperuricemia
Intervention:   Drug: Allopurinol Pill
Sponsors:   Instituto Nacional de Cardiologia Ignacio Chavez;   Instituto Nacional de Rehabilitacion
Recruiting

Maternal and Umbilical Cord Hormone Concentrations in Twin and Singleton Pregnancies

Condition:   Normal Pregnancy
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Completed

Use of Oral Anticoagulants and Symptoms in Patients With Atrial Fibrillation in Örebro County

Conditions:   Atrial Fibrillation;   Stroke, Ischemic
Intervention:   Drug: Oral anticoagulant
Sponsor:   Region Örebro County
Recruiting

The ESTxENDS Trial- Metabolic Effects of Using Electronic Nicotine Delivery Systems (ENDS/Vaporizer/E-cig)

Conditions:   Smoking Cessation;   Cardiovascular Diseases
Interventions:   Other: ENDS (vaporizer/e-cig) and smoking cessation counseling;   Other: Smoking cessation counseling
Sponsors:   University of Bern;   University of Lausanne;   University of Geneva, Switzerland;   University of Zurich;   State Hospital, St. Gallen;   Swiss National Science Foundation;   Swiss Cancer Research;   Swiss Tobacco Prevention Funds, Federal Office of Public Health
Recruiting

Efficacy of ACE Inhibitors, MRAs and ACE Inhibitor/ MRA Combination

Conditions:   Diabetic Nephropathy Type 2;   Microalbuminuria Due to Type 2 Diabetes Mellitus
Intervention:   Drug: Tritace (Ramipril 10 mg)
Sponsor:   Beni-Suef University
Recruiting

Study of the Disease Process of Lymphangioleiomyomatosis

Conditions:   Lung Disease;   Pneumothorax;   Tuberous Sclerosis;   Lymphangioleiomyomatosis
Intervention:   Device: Toshibia Aquilion One CT
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Diabetes and Heart Disease Risk in Blacks

Conditions:   Cardiovascular;   Diabetes;   Obesity;   Hypertension
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests

Condition:   Posttraumatic Stress Disorder
Interventions:   Drug: Prazosin;   Drug: Placebo
Sponsor:   VA Office of Research and Development
Recruiting

Pentoxifylline Dose Optimization in Neonatal Sepsis

Condition:   Neonatal Late Onset Sepsis
Intervention:   Drug: Pentoxifylline
Sponsor:   Erasmus Medical Center
Recruiting

Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment

Condition:   Metabolic Syndrome
Interventions:   Drug: simvastatin;   Drug: ezetimibe/simvastatin
Sponsors:   University of Maryland, Baltimore;   Merck Sharp & Dohme Corp.
Completed

Estimation Method of 24-hour Urinary Sodium Excretion by Using Spot Urine for Chinese Population

Conditions:   Urinary Sodium Excretion;   Salt Intakes
Intervention:   Other: No intervention
Sponsors:   Beijing Children's Hospital;   Capital Medical University
Recruiting

NT-proBNP Levels in the Prediction of Intrapartum and Postpartum Events in Adult Congenital Heart Disease Patients

Conditions:   Congenital Heart Disease;   Pregnancy Complications
Intervention:   Diagnostic Test: NT-proBNP
Sponsor:   Mayo Clinic
Recruiting

Southwest Health Extension Partnership to Enhance Research Dissemination

Condition:   Cardiovascular Diseases
Interventions:   Other: Enhanced practice transformation support;   Other: Standard practice transformation support
Sponsors:   University of Colorado, Denver;   University of New Mexico
Active, not recruiting

Intraoperative Implementation of the Hypotension Probability Indicator

Condition:   Intraoperative Hypotension
Intervention:   Device: FlotracIQ with HPI algorithm
Sponsor:   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Completed

Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study

Conditions:   Aging;   Arterial Stiffness;   Endothelial Dysfunction;   Hypertension;   Cognitive Decline
Interventions:   Drug: Experimental: Nitrate-containing;   Drug: Placebo: Nitrate-depleted
Sponsors:   Gary L. Pierce;   University of Wisconsin, Madison
Recruiting

Impact of Glaucoma and Visual Field Loss on Life Space

Condition:   Primary Open-angle Glaucoma
Intervention:   Other: Questionnaires
Sponsors:   University of Alabama at Birmingham;   National Institute on Aging (NIA)
Active, not recruiting

Mitral Valve in Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Obstructive Cardiomyopathy
Interventions:   Procedure: isolated septal myectomy;   Procedure: septal myectomy + edge-to-edge mitral valve repair;   Procedure: septal myectomy + posterior leaflet sliding plasty;   Procedure: septal myectomy + secondary chordae transection
Sponsor:   Tomsk National Research Medical Center of the Russian Academy of Sciences
Completed

Treadmill Exercise and GM-CSF Study to Improving Functioning in Peripheral Artery Disease (PAD)

Condition:   Peripheral Arterial Disease
Interventions:   Behavioral: Supervised Treadmill Exercise Therapy;   Other: Health education sessions (Control);   Drug: granulocyte macrophage colony stimulating factor (GM-CSF)
Sponsors:   Northwestern University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

The Effect of Pneumoperitoneum Timing on Intracranial Pressure in Laparoscopy

Conditions:   Intracranial Pressure Increase;   Pneumoperitoneum
Interventions:   Procedure: Pneumoperitoneum Timing (Before Positioning);   Procedure: Pneumoperitoneum Timing (After Positioning)
Sponsor:   Bagcilar Training and Research Hospital
Active, not recruiting

Postpartum Low-Dose Aspirin and Preeclampsia

Condition:   Preeclampsia Postpartum
Interventions:   Drug: Aspirin;   Drug: Placebo oral capsule
Sponsor:   Columbia University
Recruiting

Proof-of-Concept Trial on Selective Removal of sFlt-1 in Pregnant Women With Preeclampsia Via Apheresis

Condition:   Preeclampsia
Intervention:   Device: TheraSorb sFlt-1 adsorber
Sponsors:   Miltenyi Biotec B.V. & Co. KG;   Cromsource
Recruiting

Vasopressin in Intraabdominal Pressure Elevation

Conditions:   Intracranial Pressure Increase;   Abdominal Compartment Syndrome
Intervention:   Diagnostic Test: Study Arm
Sponsor:   The Cleveland Clinic
Active, not recruiting

Lu-177-DOTATATE (Lutathera) in Therapy of Inoperable Pheochromocytoma/ Paraganglioma

Conditions:   Pheochromocytoma;   Paraganglioma;   Neuroendocrine Tumors;   Neuroendocrine Neoplasms
Interventions:   Drug: Lu-177-DOTATATE;   Drug: Ga-68-DOTATATE;   Drug: F-18-FDG;   Drug: Amino Acid solution
Sponsor:   National Cancer Institute (NCI)
Recruiting

Study of Major Cardiovascular Events in Patients With Nonvalvular Atrial Fibrillation Treated With Rivaroxaban

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

Oral Nitrite for Older Heart Failure With Preserved Ejection Fraction

Condition:   Heart Failure
Interventions:   Drug: sodium nitrite;   Drug: Control
Sponsors:   Gladwin, Mark, MD;   National Institute on Aging (NIA)
Completed

Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity

Conditions:   Obesity;   Metabolic Syndrome X
Interventions:   Drug: Metformin;   Drug: Orlistat;   Drug: Topiramate;   Drug: Placebo
Sponsor:   University of Iowa
Suspended

Hemodynamic Optimalization in Pediatric Patients

Condition:   Hemodynamic Instability
Intervention:   Other: Vasopressor and/inotrope therapy
Sponsor:   Brno University Hospital
Not yet recruiting

BMI-Associated Labor Induction: A Prospective Trial

Condition:   Labor Induction
Intervention:   Procedure: Labor induction
Sponsor:   Baystate Medical Center
Recruiting

Placenta Imaging Project

Condition:   High Risk Pregnancy
Interventions:   Device: MRI;   Device: MRI - IUGR
Sponsors:   Oregon Health and Science University;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Pneumococcal Conjugate Vaccine in Aging Renal Transplant

Conditions:   Renal Transplantation;   Aging
Interventions:   Drug: 23 valent pneumococcal polysaccharide vaccine;   Biological: 13 valent conjugated pneumococcal vaccine;   Other: Peripheral blood sample
Sponsor:   VA Office of Research and Development
Recruiting

Canadian Alliance for Healthy Hearts and Minds

Condition:   Cardiovascular Diseases
Intervention:   Other: MRI
Sponsor:   Montreal Heart Institute
Completed

Prospective Study on DEXTENZA® Safety And Efficacy Following Concomitant MIGS and Cataract Surgery

Conditions:   Glaucoma;   Cataract
Interventions:   Drug: Dexamethasone Ophthalmic Insert;   Drug: Prednisolone Acetate 1% Oph Susp
Sponsors:   The New York Eye Surgery Center;   Ocular Therapeutix, Inc.
Recruiting

Short-term Effect of Rho-kinase Inhibitor on Retinal Circulation

Condition:   Glaucoma, Open-Angle
Intervention:   Drug: Netarsudil Ophthalmic
Sponsor:   University of the Incarnate Word
Recruiting

Ketamine to Prevent PPD After Cesarean

Condition:   Postpartum Depression
Interventions:   Drug: Ketamine 50 MG/ML;   Drug: Control
Sponsor:   Washington University School of Medicine
Not yet recruiting

Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS)

Conditions:   Systemic Lupus Erythematosus;   Antiphospholipid Syndrome
Intervention:  
Sponsors:   Hospital for Special Surgery, New York;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting

Safety and Efficacy Study of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-7902-006/E7080-G000-315/LEAP-006)

Condition:   Nonsquamous Non-small Cell Lung Cancer
Interventions:   Biological: Pembrolizumab;   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Pemetrexed;   Drug: Lenvatinib;   Drug: Placebo matching lenvatinib
Sponsors:   Merck Sharp & Dohme Corp.;   Eisai Inc.
Recruiting

Evidence-based Laboratory Test Order Sets in Primary Care

Conditions:   Diabetes Mellitus;   Hypertension;   Cardiovascular Diseases;   Fatigue;   Anemia;   Liver Diseases;   Medication Monitoring;   Gout;   Chronic Kidney Diseases;   Lung Embolism;   Acute Coronary Syndrome;   Diarrhea;   Thyroid Diseases;   Sexually Transmitted Diseases;   Rheumatoid Arthritis;   Obesity;   General Check-up
Interventions:   Other: CPOE with order sets for lab testing;   Other: CPOE without order sets for lab testing
Sponsors:   Universitaire Ziekenhuizen Leuven;   KU Leuven;   University Ghent;   Norwegian Institute of Public Health;   Sciensano
Completed

Weight Loss in Adults With Obesity Using a Combination of Low Energy Diet, Group Treatment and Intragastric Balloon

Conditions:   Obesity;   Weight Loss;   Non-Alcoholic Fatty Liver Disease
Interventions:   Dietary Supplement: Low energy diet using meal replacements;   Behavioral: CBT-based group treatment;   Device: Intragastric balloon
Sponsor:   Region Örebro County
Recruiting

Systematic Transplantectomy Versus Conventional Care After Kidney Graft Failure

Condition:   Renal Transplantation
Interventions:   Procedure: Systematic transplantectomy;   Procedure: Progressive reduction of immunosuppression
Sponsor:   Hospices Civils de Lyon
Recruiting

Phase III Trial BI 695502 Plus Chemotherapy vs. Avastin® Plus Chemotherapy in Patients With Lung Cancer

Condition:   Carcinoma, Non-Small-Cell Lung
Interventions:   Drug: BI 695502;   Drug: Avastin
Sponsor:   Boehringer Ingelheim
Completed

Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD

Condition:   Coronary Artery Disease
Interventions:   Drug: High dose potent statin;   Drug: ACE-I (lisinopril) or ARB (losartan);   Drug: Aspirin;   Behavioral: Lifestyle Counseling;   Behavioral: Quality of Life Questionnaires
Sponsors:   University of Florida;   United States Department of Defense
Recruiting

A Study to Evaluate the Safety and Effectiveness of Rivaroxaban (Xarelto) for Prevention of Stroke and Systemic Embolism in Indian Patients With Non-valvular Atrial Fibrillation (NVAF)

Condition:   Non-valvular Atrial Fibrillation (NVAF)
Intervention:   Drug: Rivaroxaban (Xarelto,Bay 59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting

Molecular Investigation of Genetic Factors in CArDiovascular Diseases Using an BIOresource of Healthy Volunteers

Condition:   Cardiovascular Diseases
Interventions:   Other: Eligibility and lifestyle restrictions check.;   Other: Medical history, demographic and lifestyle factors;   Other: Anthropometric measurements: height, weight, and body fat;   Other: Blood pressure and heart rate;   Other: Forearm blood flow: Visit 1 (EDNRA);   Other: Forearm blood flow: Visit 2 (EDNRA);   Other: Blood biochemistry (PNPLA3);   Other: Blood EPCR function (PROCR);   Other: Blood platelet coagulation and function (PROCR);   Other: Blood endothelial permeability (PROCR);   Other: Blood leukocyte-endothelium adhesion (PROCR);   Other: Baseline Venepuncture (PNPLA3, Visit 1);   Other: Deuterium water - Loading dose 1 (PNPLA3, Visit 1);   Other: Deuterium water - Loading dose 2 (PNPLA3, Visit 1);   Other: Energy-balanced dinner (PNPLA3, Visit 1);   Other: Fasting venepuncture (PNPLA3, Visit 2);   Other: Deuterium water - Maintenance dose (PNPLA3, Visit 2);   Other: Consumption of high carbohydrate meal (PNPLA3, Visit 2);   Other: Postprandial Venepuncture (PNPLA3, Visit 2);   Other: Venepuncture (PROCR)
Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   University of Cambridge
Recruiting

IOP and Medication Reduction in MIGS Procedures

Conditions:   Open Angle Glaucoma;   Primary Open Angle Glaucoma;   Pigmentary Glaucoma;   Pseudoexfoliation Glaucoma in Both Eyes
Intervention:   Procedure: Glaucoma and Cataract Surgery
Sponsors:   Wills Eye;   Tanta Medical School, Tanta University
Recruiting

Cook Enforcer Post-Market Study

Condition:   End-Stage Renal Disease
Interventions:   Device: Cook Advance® Enforcer 35 Focal-Force Percutaneous Transluminal Angioplasty (PTA) Balloon Catheter;   Device: Conventional angioplasty balloon catheters
Sponsor:   Cook Research Incorporated
Completed

Randomizing Two Gestational Diabetes Screening Methods in a Diverse HMO

Conditions:   Gestational Diabetes;   Obesity;   Pregnancy
Intervention:   Other: GDM Screening Methods
Sponsors:   Kaiser Permanente;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Enrolling by invitation

Evaluation of Patients With Liver Disease

Conditions:   Biliary Liver Cirrhosis;   Hemochromatosis;   Hepatitis;   Hepatolenticular Degeneration;   Liver Disease
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Randomized, Open Label Safety Trial of Dapivirine Vaginal Ring and Oral TRUVADA® Use in Pregnancy

Condition:   HIV Infections
Interventions:   Drug: Dapivirine (DPV) Vaginal Ring (VR);   Drug: Truvada Tablet
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting

Trial to Evaluate Reduction in Inflammation in Patients With Advanced Chronic Renal Disease Utilizing Antibody Mediated IL-6 Inhibition

Conditions:   Chronic Kidney Diseases;   Inflammation
Intervention:   Biological: Ziltivekimab
Sponsor:   Corvidia Therapeutics
Active, not recruiting

The Economic Consequences of Loneliness Among the Elderly

Condition:   Loneliness
Interventions:   Behavioral: Home visits;   Behavioral: Group activities
Sponsors:   National Bureau of Economic Research, Inc.;   National Institute on Aging (NIA);   Abdul Latif Jameel Poverty Action Lab
Not yet recruiting

The Utility of (Fractional Flow Reserve)FFR Before and After Successful Percutaneous Coronary Intervention

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   Central Arkansas Veterans Healthcare System
Active, not recruiting

A Study To Evaluate PF-06730512 In Adults With Primary Focal Segmental Glomerulosclerosis

Condition:   Focal Segmental Glomerulosclerosis (FSGS)
Intervention:   Drug: PF-06730512
Sponsor:   Pfizer
Recruiting

Carbetocin vs. Oxytocin at Elective Cesarean Section

Condition:   Postpartum Hemorrhage
Interventions:   Drug: Carbetocin;   Drug: Oxytocin
Sponsor:   Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Recruiting

Study of New Imaging Criteria for the Diagnosis of Caroli's Disease

Conditions:   Caroli Disease;   Magnetic Resonance Imaging;   Cholangiopancreatography
Intervention:   Diagnostic Test: Magnetic Resonance CholangioPancreatography
Sponsor:   Assistance Publique - Hôpitaux de Paris
Not yet recruiting

Research Study Comparing Insulin Degludec to Insulin Detemir, Together With Insulin Aspart, in Pregnant Women With Type 1 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 1
Interventions:   Drug: Insulin degludec;   Drug: Insulin Aspart;   Drug: Insulin detemir
Sponsor:   Novo Nordisk A/S
Active, not recruiting

Deflazacort vs. Prednisolone in Acute-stage ABPA

Condition:   Allergic Bronchopulmonary Aspergillosis
Interventions:   Drug: Deflazacort;   Drug: Prednisolone
Sponsor:   Postgraduate Institute of Medical Education and Research
Recruiting

DISCOVER Global Registry

Condition:   Type 2 Diabetes
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Individualized Physical Exercise Training and Enhanced Protein Intake During Rehabilitation of Elderly Citizens

Condition:   Rehabilitation
Interventions:   Other: Usual Care;   Other: Usual Care with Protein Supplementation;   Other: Individualized Physical Exercise Training with Protein Supplementation
Sponsors:   University College Absalon;   University of Southern Denmark;   Sundhed og Træning, Slagelse Municipality;   Arla Foods;   Danish Council for Independent Research;   Association of Danish Physiotherapists
Recruiting

Early Diagnosis as Strategy in Reducing the Incidence of Contrast-induced Nephropathy

Conditions:   Kidney Injury;   Contrast-induced Nephropathy
Interventions:   Diagnostic Test: Early kidney damage biomarkers;   Diagnostic Test: Predisposition to kidney injury biomarkers
Sponsors:   R. Laura Vicente Vicente;   Instituto de Investigación Biomédica de Salamanca;   Salamanca University Hospital;   University of Salamanca
Completed

End-stage Renal Disease (ESRD) Pilot Study

Condition:   Renal Dialysis
Interventions:   Drug: BAY1213790;   Drug: 0.9% sodium chloride solution
Sponsor:   Bayer
Recruiting

Comparison of the Human Acellular Vessel (HAV) With Fistulas as Conduits for Hemodialysis

Conditions:   Renal Failure;   End Stage Renal Disease;   Hemodialysis;   Vascular Access
Interventions:   Biological: Human Acellular Vessel (HAV);   Procedure: Arteriovenous fistula (AVF)
Sponsors:   Humacyte, Inc.;   CTI Clinical Trial and Consulting Services;   California Institute for Regenerative Medicine (CIRM)
Recruiting

EMPA-KIDNEY (The Study of Heart and Kidney Protection With Empagliflozin)

Condition:   Chronic Kidney Disease
Interventions:   Drug: Empagliflozin;   Drug: Matching placebo
Sponsors:   Boehringer Ingelheim;   Medical Research Council Population Health Research Unit, CTSU, University of Oxford (academic lead);   Eli Lilly and Company
Recruiting

EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)

Condition:   Heart Failure
Interventions:   Drug: Empagliflozin;   Drug: Placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting

EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)

Condition:   Heart Failure
Interventions:   Drug: Empagliflozin;   Drug: Placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting

Nebulized Midazolam, Dexmedetomidine, and Their Combination in Sedation of Preschoolers Undergoing Dental Treatment

Condition:   Dental Anxiety
Interventions:   Drug: Midazolam group (MDZ);   Drug: Dexmedetomidine group (DEX);   Drug: Combination of Midazolam and Dexmedetomidine (MDZ/DEX)
Sponsors:   Nourhan M.Aly;   Alexandria University
Completed

Ascertain the Optimal Starting Dose of Mircera Given Subcutaneously for Maintenance Treatment of Anemia in Pediatric Patients With Chronic Kidney Disease on Dialysis or Not Yet on Dialysis.

Conditions:   Anemia;   Renal Insufficiency, Chronic
Intervention:   Drug: Mircera
Sponsor:   Hoffmann-La Roche
Recruiting

Trajectories of Glomerular Filtration Rate and Progression to End Stage Renal Disease After Kidney Transplantation

Conditions:   Kidney Transplant Failure;   Kidney Function Issue
Intervention:   Other: No intervention
Sponsor:   Paris Translational Research Center for Organ Transplantation
Recruiting

Triple Procedure for Dense Cataractus Neovascular Glaucoma Patients

Conditions:   IOP Decreased;   Visual Impairment
Intervention:   Procedure: Procedure
Sponsor:   Minia University
Completed

Apatinib in Refractory Colorectal Cancer

Condition:   Colorectal Neoplasms
Intervention:   Drug: apatinib
Sponsors:   The First Affiliated Hospital with Nanjing Medical University;   Jiangsu HengRui Medicine Co., Ltd.;   Beijing gene plus technology co., LTD
Completed

Postpartum Hemorrhage Prevention in Patients With Preeclampsia (PHP3 Study)

Condition:   Preeclampsia
Interventions:   Drug: Oxytocin;   Drug: Placebo
Sponsor:   University of Colorado, Denver
Recruiting

Improved Self-management for Patients on Ventricular Assist Device (VAD)

Conditions:   Ventricular Assist Device;   Self-management;   Psychological Factors
Intervention:   Other: Prevalence Survey
Sponsors:   University of Freiburg;   University Heart Center Freiburg - Bad Krozingen;   Heart and Diabetes Center North-Rhine Westfalia;   German Heart Center;   Heart Center Leipzig - University Hospital
Recruiting