High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Social Media Use ,Online Health Information Seeking and Knowledge on Hypertension

Conditions:   Hypertension;   Knowledge, Attitudes, Practice;   Social Behavior
Intervention:  
Sponsor:   Universiti Putra Malaysia
Not yet recruiting

Learning Implementation of Guideline-based Decision Support System for Hypertension Treatment (LIGHT)

Condition:   Hypertension
Intervention:   Behavioral: Computer-based decision support system
Sponsor:   China National Center for Cardiovascular Diseases
Recruiting

China Rural Hypertension Control Project

Condition:   Hypertension
Interventions:   Other: Strengthen the performance appraisal system;   Other: Establishing a chronic disease management system;   Other: Simulating medical insurance reform;   Other: Enhancing village doctors'ability.;   Other: Establishing a supervision mechanism for the effect;   Other: Establishing a hierarchical management system for patients;   Behavioral: Enhancing the awareness of blood pressure self-management;   Behavioral: Establishing a self-management group;   Other: Establishing patient encouragement system
Sponsors:   First Hospital of China Medical University;   Tulane University;   Soochow University;   Huazhong University of Science and Technology;   Health Science Center of Xi’an Jiaotong University;   Liaoning Center for Disease Control and Prevention
Active, not recruiting

Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension

Conditions:   Tourniquet Hypertension;   Intraoperative Hypertension;   Total Ankle Arthroplasty;   Ankle Fusion
Interventions:   Drug: Mepivacaine;   Drug: Saline;   Procedure: Perifemoral Injection of Local Anesthetic
Sponsor:   Duke University
Not yet recruiting

Acute Decompensation of Pulmonary Hypertension

Conditions:   Hypertension, Pulmonary;   Biomarkers
Intervention:   Other: A biobank will be created from blood samples taken at admission, days 3 and days 7
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting

Natural History Study of Biomarkers in Pulmonary Arterial Hypertension

Conditions:   Pulmonary Disease;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Institutes of Health Clinical Center (CC)
Recruiting

Advanced Practice Nurse Intervention Versus Usual Care for Hypertension Control

Condition:   Hypertension
Intervention:   Behavioral: APN intervention
Sponsor:   Hotel Dieu University Hospital, France
Not yet recruiting

A Study of LY2623091 in Participants With High Blood Pressure

Condition:   Primary Hypertension
Interventions:   Drug: LY2623091;   Drug: Tadalafil;   Drug: Spironolactone;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Completed

Angiotensin 1-7 in Obesity Hypertension

Conditions:   Obesity;   Hypertension
Interventions:   Drug: Angiotensin-(1-7);   Drug: Saline
Sponsors:   Amy Arnold;   American Heart Association
Recruiting

Fluoxetine in Pulmonary Arterial Hypertension (PAH) Trial

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Fluoxetine
Sponsor:   University of Texas Southwestern Medical Center
Completed

Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia

Conditions:   Pulmonary Hypertension;   Sickle Cell Anemia;   Sickle Cell Disease
Intervention:  
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Endothelial Cell Dysfunction in Pulmonary Hypertension

Condition:   Secondary Pulmonary Arterial Hypertension
Intervention:   Procedure: Heart Catheterization
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed

A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn

Condition:   Pulmonary Hypertension, Familial Persistent, of the Newborn
Interventions:   Drug: placebo;   Drug: iv sildenafil
Sponsor:   Pfizer
Active, not recruiting

DASH Diet Intervention at Senior Centers

Condition:   Hypertension
Interventions:   Behavioral: Revision of congregate meal menus and recipes to align with parameters of DASH eating plan;   Behavioral: On-site blood pressure monitoring;   Behavioral: Home self blood pressure monitoring;   Behavioral: Medical adherence education;   Behavioral: Nutrition Education
Sponsors:   Rockefeller University;   Carter Burden Network;   Clinical Directors Network
Active, not recruiting

miRNA and Myokines in Patients With PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Other: Exercise Rehab
Sponsor:   University of Pittsburgh
Recruiting

HRV as a Marker of Treatment Response in PAH Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Device: Noninvasive actigraphy monitor
Sponsor:   University of Cincinnati
Not yet recruiting

Genetic and Environmental Determinants That Control Metabolism in Pulmonary Hypertension

Conditions:   Iron-sulfur Cluster Deficiency;   Pulmonary Hypertension;   Friedreich Ataxia
Interventions:   Procedure: Right Heart Catheterization;   Other: Blood draw
Sponsor:   University of Pittsburgh
Recruiting

Oral Sildenafil in Persistent Pulmonary Hypertension Secondary to Meconium Aspiration Syndrome in Newborns

Conditions:   Meconium Aspiration Syndrome;   Persistent Pulmonary Hypertension of Newborn
Interventions:   Drug: Oral Sildenafil;   Drug: Placebo (distilled water)
Sponsor:   Sir Takhtasinhji General Hospital
Completed

Anxiety Self-management Intervention for Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Pulmonary Arterial Hypertension;   Anxiety;   Anxiety Disorders
Intervention:   Other: Cognitive Behavioural therapy self help intervention for anxiety
Sponsor:   University of Sheffield
Not yet recruiting

A Study Evaluating the 24-Hour Intraocular Pressure Lowering Effect of Bimatoprost SR in Patients With Open-Angle Glaucoma or Ocular Hypertension

Conditions:   Open-Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: Bimatoprost SR;   Drug: LUMIGAN
Sponsor:   Allergan
Recruiting

Effect of Hypercholesterolemia With or Without Hypertension on Coronary Artery Stenosis in Patients With Angina: a Retrospective Study

Condition:   Atherosclerotic Heart Disease With Angina Nos
Intervention:  
Sponsor:   Tianjin University of Traditional Chinese Medicine
Not yet recruiting

Phase 3 Trial of NCX 470 vs. Latanoprost in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Conditions:   Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: NCX 470 0.065%;   Drug: NCX 470 0.1%;   Drug: Latanoprost 0.005%
Sponsor:   Nicox Ophthalmics, Inc.
Recruiting

Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension

Conditions:   Glaucoma, Open-Angle;   Ocular Hypertension
Interventions:   Drug: Bimatoprost SR;   Drug: Sham Bimatoprost SR;   Procedure: Selective Laser Trabeculoplasty;   Procedure: Sham Selective Laser Trabeculoplasty
Sponsor:   Allergan
Recruiting

Safety and Efficacy of Bimatoprost Sustained-Release (SR) in Patients With Open-Angle Glaucoma or Ocular Hypertension

Conditions:   Glaucoma, Open-Angle;   Ocular Hypertension
Interventions:   Drug: Bimatoprost sustained-release;   Other: Sham;   Drug: Timolol;   Drug: Timolol Vehicle (placebo)
Sponsor:   Allergan
Completed

Aerobic Exercise in Patients With Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease
Intervention:   Other: Aerobic exercise
Sponsors:   National Institutes of Health Clinical Center (CC);   George Mason University;   Inova Fairfax Hospital
Completed

A Comparison of Bimatoprost SR to Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma or Ocular Hypertension

Conditions:   Glaucoma;   Open-Angle Ocular Hypertension
Interventions:   Drug: Bimatoprost SR;   Drug: Sham Bimatoprost SR;   Procedure: Selective Laser Trabeculoplasty;   Procedure: Sham Selective Laser Trabeculoplasty
Sponsor:   Allergan
Active, not recruiting

Nourish: Digital Health DASH Dietary Pattern Trial for Adults With Hypertension

Conditions:   Hypertension;   Health Behavior
Intervention:   Behavioral: Tracking Plus coaching
Sponsor:   Duke University
Not yet recruiting

Invasive Versus Non Invasive Measurement of Intracranial Pressure in Brain Injury Trial (IMPRESSIT)

Condition:   Intracranial Hypertension
Intervention:   Device: transcranial Doppler
Sponsors:   Università degli Studi di Brescia;   Rita Bertuetti;   Chiara Robba
Recruiting

A Study of Single Doses of MK -5475 on Pulmonary Vascular Resistance (MK-5475-002)

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: MK-5475;   Drug: Placebo
Sponsor:   Merck Sharp & Dohme Corp.
Recruiting

Dietary Approaches to Stop Hypertension for Diabetes

Conditions:   Diabetes Mellitus, Type 2;   Diabetes;   Diabetes type2;   Type2 Diabetes;   Type 2 Diabetes;   Type II Diabetes;   Hypertension;   High Blood Pressure
Interventions:   Other: DASH4D diet;   Other: comparison diet;   Other: higher sodium;   Other: lower sodium
Sponsors:   Johns Hopkins University;   Beth Israel Deaconess Medical Center
Not yet recruiting

Chlorhexidine Mouthwash and Oral Nitrate in Adults With Pulmonary Hypertension

Conditions:   Pulmonary Hypertension;   Heart Failure With Normal Ejection Fraction;   Pulmonary Heart Disease and Diseases of Pulmonary Circulation
Interventions:   Drug: Nitrates;   Drug: Chlorhexidine Gluconate Mouthwash;   Drug: Placebo Mouthwash
Sponsors:   Gladwin, Mark, MD;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI);   University of Pittsburgh
Not yet recruiting

RV Conductance Catheter Assessment During Balloon Pulmonary Angioplasty

Condition:   Chronic Thromboembolic Pulmonary Hypertension
Intervention:   Procedure: Balloon pulmonary angioplasty
Sponsor:   Papworth Hospital NHS Foundation Trust
Not yet recruiting

A Clinical Study to Evaluate the Efficacy and Safety of CKD-351

Conditions:   Primary Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: CKD-351;   Drug: Latanoprost+Dorzolmamide
Sponsor:   Chong Kun Dang Pharmaceutical
Recruiting

SPYRAL HTN-ON MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Enrolling by invitation

Coronavirus (COVID-19) ACEi/ARB Investigation

Conditions:   Hypertension;   COVID-19
Interventions:   Drug: Thiazide or Thiazide-like diuretics;   Drug: Calcium Channel Blockers;   Drug: ACE inhibitor;   Drug: Angiotensin receptor blocker
Sponsor:   National University of Ireland, Galway, Ireland
Suspended

REMODEL: Hypertensive Heart Disease

Conditions:   Left Ventricular Hypertrophy;   Hypertension;   Myocardial Fibrosis
Interventions:   Other: Cardiovascular Magnetic Resonance;   Other: Echocardiogram;   Other: Electrocardiogram;   Device: Ambulatory Blood Pressure Monitoring;   Other: Retinal Photography (Optional)
Sponsor:   National Heart Centre Singapore
Recruiting

Controlling Hypertension Through Education and Coaching in Kidney Disease

Conditions:   Chronic Kidney Diseases;   Chronic Disease;   Chronic Kidney Disease, Stage 3 (Moderate);   Chronic Kidney Disease, Stage 4 (Severe);   Chronic Kidney Disease Stage 5
Interventions:   Behavioral: Control-EDI;   Behavioral: Intervention-EDI and health coaching
Sponsors:   University of Michigan;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Comparison of the Effects of Deep and Moderate Neuromuscular Blockade on Optic Nerve Sheath Diameter

Condition:   Intracranial Hypertension
Interventions:   Diagnostic Test: Ultrasonographic measurement of optic nerve sheath diameter;   Procedure: Deep neuromuscular block;   Procedure: Moderate neuromuscular block
Sponsor:   Bezmialem Vakif University
Not yet recruiting

Normotensive and Hypertensive Placental Abruptions

Condition:   Abruptio Placentae; Affecting Fetus or Newborn
Intervention:   Other: clinical assesment
Sponsor:   Hatice Akkaya
Completed

Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

Conditions:   Obstructive Sleep Apnea of Adult;   Preeclampsia;   Obstetrical Complications
Interventions:   Device: Continuous Positive Airway Pressure;   Other: Sleep Hygiene Control
Sponsors:   The George Washington University Biostatistics Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

The Comparison Between Spironolactone and Indapamide Monotherapy or in Combination With Amlodipine to Reduce the Risk of Heart Failure

Condition:   Hypertension
Interventions:   Drug: Spironolactone;   Drug: Indapamide
Sponsor:   Shanghai Jiao Tong University School of Medicine
Not yet recruiting

Effects of Vitamin D and Fish Oil on the Kidney in Hypertensives

Conditions:   Hypertension;   Kidney Diseases
Interventions:   Dietary Supplement: Vitamin D3;   Drug: Omega-3 Fatty acids;   Dietary Supplement: Vitamin D3 placebo;   Dietary Supplement: Fish oil placebo
Sponsors:   Albert Einstein College of Medicine;   Brigham and Women's Hospital;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Human Sodium Balance Study

Condition:   Hypertension
Interventions:   Other: High dietary sodium intake;   Other: Low dietary sodium intake
Sponsor:   University of California, San Diego
Not yet recruiting

Communicating Health Information and Improving Coordination With Primary Care

Conditions:   Hypertension;   Dyslipidemias;   Diabetes;   Childhood Cancer
Interventions:   Behavioral: Education;   Behavioral: Test results only
Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI);   St. Jude Children's Research Hospital
Enrolling by invitation

The Galway Sea Swimmers Study

Conditions:   Cardiovascular Diseases;   Hypertension
Interventions:   Other: Cold-water sea swimming;   Other: No cold-water sea swimming
Sponsor:   National University of Ireland, Galway, Ireland
Suspended

Assessment of Lifestyle, Blood Pressure, Cholesterol and Glycated Hemoglobin in a Specific Population

Conditions:   Cholesterol; Lipidosis;   Arterial Hypertension;   Blood Glucose, High
Intervention:  
Sponsor:   Libbs Farmacêutica LTDA
Recruiting

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Condition:   Hypertension
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

Pravastatin to Prevent Preeclampsia

Conditions:   Preeclampsia;   Obstetric Labor Complications;   Hypertension in Pregnancy
Interventions:   Drug: Pravastatin;   Other: Placebo
Sponsors:   The George Washington University Biostatistics Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

SPYRAL DYSTAL Clinical Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Intervention:   Device: Renal Denervation (Symplicity Spyral™)
Sponsor:   Medtronic Vascular
Recruiting

Comprehensive Treatment of Angina in Women With Microvascular Dysfunction

Conditions:   Angina Pectoris;   Coronary Microvascular Disease
Interventions:   Dietary Supplement: Diet;   Behavioral: Training;   Drug: Medication (with statin and ACE-inhibition)
Sponsors:   Bispebjerg Hospital;   University Hospital Bispebjerg and Frederiksberg;   Cambridge Weight Plan Limited
Completed

A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

Conditions:   PAH;   Pulmonary Hypertension;   Pulmonary Arterial Hypertension;   Hypertension;   Connective Tissue Diseases;   Familial Primary Pulmonary Hypertension;   Vascular Diseases;   Cardiovascular Diseases;   Hypertension, Pulmonary;   Lung Diseases;   Respiratory Tract Disease
Intervention:   Drug: Ralinepag
Sponsor:   United Therapeutics
Enrolling by invitation

Intraocular Pressure in Ocular Hypertensives With Scleral Lens Wear

Condition:   Ocular Hypertension
Intervention:   Device: Scleral Lens
Sponsor:   Mayo Clinic
Recruiting

Accuracy of Non-Invasive Blood Pressure Measurements at the Arm, Calf , and Finger

Conditions:   Hypotension and Shock;   Hypertension;   Intensive Care Unit
Intervention:   Device: Combined non-invasive intermittent (oscillometric arm cuff), non-invasive continuous (finger cuff and ClearSight device), and invasive continuous (intra-arterial catheter) BP measurements
Sponsor:   Centre Hospitalier Régional d'Orléans
Recruiting

Chickasaw Healthy Eating Environments Research Study

Conditions:   Blood Pressure;   Body Weight
Intervention:   Behavioral: Packed Promise for a Healthy Heart
Sponsors:   Oklahoma State University Center for Health Sciences;   The Chickasaw Nation;   Washington State University
Recruiting

Assessing Open Access Audio

Conditions:   Hypertension;   Diabetes
Intervention:   Other: Open Access Audio
Sponsor:   VA Office of Research and Development
Not yet recruiting

Resveratrol and Cardiovascular Health in the Elderly

Conditions:   Vascular Resistance;   Hypertension
Interventions:   Dietary Supplement: Resveratrol;   Drug: Placebo
Sponsor:   National Institute on Aging (NIA)
Recruiting

Effects of an Indoor Cycling Program on Cardio-Metabolic Factors in Women With Obesity and Normal Body Weight

Conditions:   Obesity;   Dyslipidemias;   Hypertension;   Type 2 Diabetes;   Endothelial Dysfunction
Intervention:   Behavioral: Indoor Cycling Interval Exercise Training
Sponsors:   Poznan University of Physical Education;   Poznan University of Medical Sciences
Completed

A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Conditions:   PAH;   Pulmonary Hypertension;   Pulmonary Arterial Hypertension;   Hypertension;   Connective Tissue Diseases;   Familial Primary Pulmonary Hypertension;   Vascular Diseases;   Cardiovascular Diseases;   Hypertension, Pulmonary;   Lung Diseases;   Respiratory Tract Disease
Interventions:   Drug: Ralinepag;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting

The Effect of Early Screening and Intervention for Gestational Diabetes Mellitus on Pregnancy Outcomes

Conditions:   Pregnancy Complications;   Gestational Diabetes Mellitus in Pregnancy
Interventions:   Other: early screening and intervention;   Other: standard screening and intervention
Sponsor:   National Taiwan University Hospital
Recruiting

A Study Using the LMC Diabetes Registry to Learn More About Chronic Kidney Disease (CKD) in Canadian Patients With Type 2 Diabetes (T2D)

Condition:   Chronic Kidney Disease in Type 2 Diabetes
Intervention:   Drug: The physician's prescription in routine clinical practice
Sponsor:   Bayer
Not yet recruiting

Outcome in Patients Treated With Intraarterial Thrombectomy - optiMAL Blood Pressure Control (OPTIMAL-BP)

Condition:   Ischemic Stroke
Interventions:   Drug: conventional blood pressure control (labetalol, nicardipine);   Drug: intensive blood pressure control (labetalol, nicardipine)
Sponsor:   Yonsei University
Recruiting

Lung Transplant G0 (LTGO): Improving Self-Management of Exercise After Lung Transplantation

Conditions:   Exercise;   Lung Transplantation
Interventions:   Behavioral: LTGO-Home Based Exercise;   Behavioral: Enhanced Usual Care
Sponsors:   University of Pittsburgh;   National Institute of Nursing Research (NINR)
Recruiting

Prospective Multicenter Study on the Identification of Genetic Abnormalities Predisposing to Vasospasm From a Privileged Model: the Primary Raynaud's Phenomenon

Conditions:   Primary Raynaud's Phenomenon (PR);   Genetic Mutations Causing PR;   Study of Patients and Their Relatives (With or Without Primary PR)
Intervention:   Genetic: Demonstration of genetic mutations causing Raynaud's phenomenon
Sponsor:   Nantes University Hospital
Completed

Blood Pressure in Blacks and Calcium (BBC) and Vitamin D Study

Conditions:   Hypertension;   Vitamin D Deficiency
Intervention:   Drug: Cholecalciferol
Sponsor:   Loyola University
Completed

RNA Sequencing in the Framingham Heart Study Third Generation Cohort Exam 2

Conditions:   Cardiovascular Disease;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial

Conditions:   Acute Intracerebral Haemorrhage (ICH);   Hypertension
Interventions:   Drug: telmisartan 20mg, amlodipine 2.5mg, and indapamide 1.25mg;   Drug: Placebo
Sponsor:   The George Institute
Recruiting

Genetics of Type 2 Diabetes in West Africans

Conditions:   Hypertension;   Diabetes
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

Genetics of Type 2 Diabetes Among Han Chinese

Conditions:   Diabetes;   Hypertension
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Completed

miRNA-452 in Patients With Preeclampsia and Its Correlation With MMP-9

Condition:   Preeclampsia
Intervention:   Genetic: real time PCR (rPCR)
Sponsor:   Assiut University
Completed

Study Evaluating the Efficacy and Safety of Belapectin (GR-MD-02) for the Prevention of Esophageal Varices in NASH Cirrhosis

Conditions:   Prevention of Esophageal Varices;   NASH - Nonalcoholic Steatohepatitis;   Cirrhosis
Interventions:   Drug: belapectin;   Drug: Placebo
Sponsor:   Galectin Therapeutics Inc.
Recruiting

Selected Disorders and Sleep Bruxism

Conditions:   Sleep Bruxism;   Hypertension;   Thyroid Dysfunction;   Mental Status Change;   Sleep Apnea;   Sleep Disorders;   Cardiovascular Risk Factor;   Cardiovascular Diseases;   Temporomandibular Disorder
Intervention:   Drug: Opipramol
Sponsor:   Wroclaw Medical University
Enrolling by invitation

Predicting Late-onset Preeclampsia at 10-14 Weeks of Pregnancy

Condition:   Preeclampsia
Intervention:  
Sponsor:   University of Southern Denmark
Enrolling by invitation

Early Gestational Diabetes Screening in the Gravid Obese Woman

Conditions:   Gestational Diabetes;   Obesity
Intervention:   Other: Early Screen
Sponsors:   University of Alabama at Birmingham;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   Ochsner Health System
Completed

Individualizing Disease Prevention for Middle-Aged Adults

Condition:   Primary Health Care
Intervention:   Other: Intervention
Sponsor:   Glen Taksler
Suspended

Telmisartan to Reduce AIDS-Related Fibrotic and Inflammatory Contributors (TRAFIC Study)

Condition:   HIV-1 Infection
Intervention:   Drug: Telmisartan
Sponsors:   AIDS Clinical Trials Group;   National Institute of Allergy and Infectious Diseases (NIAID)
Completed

Gut Microbiome and Obesity

Conditions:   Obesity, Childhood;   Metabolic Syndrome
Intervention:   Other: Obese with or without metabolic syndromesubjects
Sponsor:   Federico II University
Recruiting

OCT Angiography in the Glaucoma Diagnosis

Condition:   Glaucoma
Interventions:   Diagnostic Test: Case Group;   Diagnostic Test: Control Group
Sponsor:   Groupe Hospitalier Paris Saint Joseph
Recruiting

Carnitine for the Treatment of Atherosclerosis.

Condition:   Metabolic Syndrome
Interventions:   Dietary Supplement: L-carnitine capsules;   Dietary Supplement: Cellulose capsules
Sponsors:   Dr. Amer Johri;   Heart and Stroke Foundation of Canada;   Queen's University
Completed

PDA Post NICU Discharge

Condition:   Patent Ductus Arteriosus
Intervention:  
Sponsor:   Mednax Center for Research, Education, Quality and Safety
Completed

Immune Biomarkers of Outcome From COVID-19

Condition:   COVID-19
Intervention:   Diagnostic Test: Peripheral blood sampling
Sponsor:   University Hospital Plymouth NHS Trust
Recruiting

Postprandial Glucose, Insulin Responses and Appetite Hormones to Dried Mushrooms

Condition:   Metabolic Syndrome
Intervention:   Other: Breakfast meals
Sponsor:   Harokopio University
Recruiting

A Study on the Effects of Nutritious Mushrooms in Adults With Metabolic Syndrome

Condition:   Metabolic Syndrome
Intervention:   Other: Nutritious Mushrooms
Sponsor:   Harokopio University
Not yet recruiting

Can Rivaroxaban Lead to Anticoagulation-Related Nephropathy?

Condition:   Acute Kidney Injury
Intervention:  
Sponsor:   Albert Einstein Healthcare Network
Completed

Precise High Resolution MRI to Increase Accuracy and Gain Confidence to Diagnose Patients With Optic Disc Edema

Conditions:   Optic Disk;   Magnetic Resonance Imaging
Intervention:   Other: MRI
Sponsor:   Fondation Ophtalmologique Adolphe de Rothschild
Active, not recruiting

Point-of-care-Ultrasound for Sleep Apnea

Condition:   Sleep Apnea, Obstructive
Intervention:  
Sponsor:   Rakesh Sondekoppam Vijayashankar
Recruiting

Prognosis of Coronavirus Disease 2019 (COVID-19) Patients Receiving Receiving Antihypertensives

Condition:   COVID-19
Intervention:   Drug: Angiotensin-Converting Enzyme Inhibitors (ACE-I) and Angiotensin II Receptor Blockers (ARB)
Sponsors:   Hakeam Abdulaziz Hakeam;   Buraidah Central Hospital;   King Khalid University Hospital;   Princess Nourah Bint Abdulrahman University
Recruiting

Heart Catheterization Using Magnetic Resonance Imaging (MRI) Fluoroscopy and Passive Guidewires

Conditions:   Pulmonary Artery Hypertension;   Congenital Heart Disease;   Structural Heart Disease
Intervention:   Procedure: MRI Right and Left Heart guidewire catheterization
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Effect of Acupuncture on Nausea, Vomiting, Pain, PGE2 and IL 6 in Septorhinoplasty

Conditions:   Pain;   Acupuncture
Intervention:   Device: Acupuncture Pres Needle: 0.22x1.5 mm needle
Sponsor:   Kahramanmaras Sutcu Imam University
Completed

Gut Microbiota, "Spark and Flame" of COVID-19 Disease

Condition:   COVID-19
Intervention:   Other: Exposure
Sponsors:   Universidade Nova de Lisboa;   NOVA Medical School of Universidade NOVA de Lisboa;   Hospital de São Francisco Xavier, Centro Hospitalar de Lisboa Ocidental;   Centro Hospitalar Universitário São João;   CUF Academic and Research Medical Center;   Hospital CUF Infante Santo, S.A.;   Centro de Medicina Laboratorial Germano de Sousa, S.A.;   CINTESIS - Center for Health Technology and Services Research
Recruiting

Development and Evaluation of mHealth Solutions to Monitor and Involve Cardiometabolic Patients in Self-care

Conditions:   Hypertension;   Diabetes;   Heart Failure;   Copd;   Asthma;   Obesity
Intervention:   Device: Mobile application
Sponsor:   Universidad Miguel Hernandez de Elche
Recruiting

Oxygen Savings With Administered Oxygen and High Flow Ambient Air At Rest

Conditions:   Pulmonary Disease, Chronic Obstructive;   Lung Diseases, Interstitial;   Pulmonary Fibrosis;   Hypoxemia;   Dyspnea;   Oxygen Inhalation Therapy
Interventions:   Device: Nasal Delivery of High-Flow Air and Oxygen Therapy;   Device: Nasal Delivery of Oxygen Therapy
Sponsor:   Johns Hopkins University
Not yet recruiting

Long Acting Buprenorphine Injection Compared to Sublingual Buprenorphine/Naloxone Films

Condition:   Opioid Use
Interventions:   Drug: Suboxone® SL;   Drug: Sublocade®
Sponsor:   Wake Forest University Health Sciences
Not yet recruiting

Modifying Diet to Improve Gut Microbiome

Condition:   Obesity
Interventions:   Behavioral: DASH diet;   Behavioral: standard American diet
Sponsor:   University of Alabama at Birmingham
Recruiting

The Neuroprotective Effects of Dexmedetomidine During Brain Surgery

Conditions:   Brain Tumor;   Cerebrovascular Disorders
Intervention:   Drug: Dexmedetomidine
Sponsor:   National Taiwan University Hospital
Completed

DNA Repair in Patients With Stable Angina.

Conditions:   Coronary Artery Disease;   Coronary Arteriosclerosis;   DNA Damage;   DNA Repair Abnormality
Intervention:  
Sponsor:   University Hospital Southampton NHS Foundation Trust
Active, not recruiting

Effects of Endothelin Receptor Antagonist on Ischemic Kidney Injury During Nephron Sparing Surgery

Condition:   Kidney Failure, Acute
Intervention:   Drug: Ambrisentan 10 MG
Sponsors:   Bnai Zion Medical Center;   Rambam Health Care Campus
Active, not recruiting

The Effect of Lidocaine on Smooth Emergence With Double Lumen Tube

Conditions:   Cough;   Lidocaine
Interventions:   Drug: Lidocaine Iv;   Drug: Remifentanil
Sponsor:   Ajou University School of Medicine
Not yet recruiting

Investigating Idiopathic Pulmonary Fibrosis in Greece (INDULGE IPF)

Condition:   Idiopathic Pulmonary Fibrosis
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Optimizing Outcomes With Physical Therapy Treatment for IndividuALs Surviving an ICU Admission for Covid-19

Conditions:   Covid-19;   Critical Illness;   Post Intensive Care Unit Syndrome;   Muscle Weakness
Intervention:   Other: ICU Recovery + Physical Therapy
Sponsors:   University of Kentucky;   Ashley Montgomery-Yates
Recruiting

Vitamin D Deficiency and Dysautonomia

Conditions:   Vitamin D Deficiency;   Orthostatic Intolerance;   Nausea
Intervention:   Dietary Supplement: vitamin D supplement
Sponsor:   Wake Forest University Health Sciences
Active, not recruiting

Bioavailability of Single-dose Magnesium Salts

Condition:   Bioavailability
Interventions:   Dietary Supplement: Picometer-ionic form of magnesium chloride;   Dietary Supplement: Magnesium citrate or magnesium oxide;   Dietary Supplement: Placebo
Sponsors:   Think Healthy Group, Inc.;   Indiana University
Recruiting

Clinical Laboratory Evaluation of Chronic Autonomic Failure

Conditions:   Parkinson's Disease;   Multiple System Atrophy;   Autonomic Failure
Interventions:   Drug: 18F-Dopa;   Drug: 11C-methylreboxetine;   Drug: 13N-Ammonia;   Drug: 18F-Dopamne;   Drug: Desipramine (DMI)
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Romanian Kidney Transplant Cardiovascular Risk Registry

Conditions:   Kidney Transplant; Complications;   Cardiovascular Diseases
Interventions:   Device: Bioimpedance Spectroscopy;   Device: Arterial Stiffness;   Diagnostic Test: Echocardiography;   Diagnostic Test: Lung ultrasonography
Sponsor:   Grigore T. Popa University of Medicine and Pharmacy
Recruiting

The Effect of Eplerenone on the Evolution of Vasculopathy in Renal Transplant Patients.

Condition:   Patients With a Kidney Transplantation for More Than One Year and on Cyclosporine
Interventions:   Drug: Eplerenone 50mg/day (cross over design);   Other: Period without eplerenone (cross over design)
Sponsor:   Central Hospital, Nancy, France
Not yet recruiting

Effect of Midodrine on HVPG in Advanced Chronic Liver Disease

Condition:   Chronic Liver Disease
Intervention:   Drug: Midodrine Oral Tablet
Sponsor:   Institute of Liver and Biliary Sciences, India
Not yet recruiting

Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry

Condition:   Paroxysmal Nocturnal Hemoglobinuria
Intervention:  
Sponsor:   Alexion Pharmaceuticals
Recruiting

Reference Values for Plasma Catechols

Conditions:   Healthy Volunteers;   Normal Physiology
Interventions:   Other: Food-Coffee;   Other: Food-Banana;   Other: Food-Olive;   Other: Temp. Manip.
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Normotonic Partial Nephrectomy as Novel Approach in Treating Small Renal Masses

Conditions:   Renal Malignant Tumor;   Renal Tumor
Interventions:   Procedure: Normotonic partial nephrectomy;   Procedure: Hypotonic partial nephrectomy
Sponsor:   Saint Petersburg State University, Russia
Recruiting

Study of the Disease Process of Lymphangioleiomyomatosis

Conditions:   Lung Disease;   Pneumothorax;   Tuberous Sclerosis;   Lymphangioleiomyomatosis
Intervention:   Device: Toshibia Aquilion One CT
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Effects of Short-term Interventions for a Healthy Lifestyle on the Human Lipidome in Subjects With Metabolic Syndrome

Conditions:   Metabolic Syndrome;   NAFLD;   Obesity;   Hypertension
Interventions:   Behavioral: Lifestyle intervention (physical activity);   Dietary Supplement: Lifestyle intervention (PUFA/isomaltulose-enriched muffin)
Sponsor:   German Institute of Human Nutrition
Recruiting

Assessment of Progranulin and FAM19A5 Protein Blood Levels in Metabolic Syndrome

Conditions:   Nutrition Disorders;   Hypertension;   Dyslipidemias;   Glucose Intolerance;   Glucose Metabolism Disorders;   Obesity;   Overweight and Obesity;   Metabolic Syndrome
Interventions:   Diagnostic Test: Blood sample collection;   Diagnostic Test: Hair sample collection;   Diagnostic Test: Urine sample collection;   Diagnostic Test: Body composition analysis;   Diagnostic Test: Questionnaires;   Diagnostic Test: Blood pressure, pulse and blood oxygen saturation measurement
Sponsor:   Poznan University of Medical Sciences
Not yet recruiting

Assessment of Remifentanil for Rapid Sequence Induction and Intubation in Full Stomach Patient Compared to Muscle Relaxant

Condition:   Intra-tracheal Intubation
Interventions:   Drug: Remifentanil group;   Drug: neuromuscular blockade group
Sponsor:   Nantes University Hospital
Recruiting

Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests

Condition:   Posttraumatic Stress Disorder
Interventions:   Drug: Prazosin;   Drug: Placebo
Sponsor:   VA Office of Research and Development
Active, not recruiting

TACkLE Study - Tackling Adverse Chemotherapy-associated Late Effects

Condition:   Testicular Cancer
Intervention:   Other: Vena punction
Sponsors:   University Medical Center Groningen;   The Netherlands Cancer Institute
Active, not recruiting

Nutritional Habits, and Coronavirus Disease 2019 (COVID-19) Outcome

Conditions:   Covid19;   Chronic Inflammation;   Non-Communicable Chronic Diseases
Intervention:  
Sponsor:   Cairo University
Recruiting

A 12-Week, Phase 2 Study of Gemcabene in Hypercholesterolemia Patients on Stable Moderate and High-Intensity Statins

Condition:   Hypercholesteremia
Interventions:   Drug: Gemcabene;   Drug: Placebo
Sponsor:   NeuroBo Pharmaceuticals Inc.
Completed

Dilapan-S®: A Multicenter US E-registry

Conditions:   Post Term Pregnancy;   Premature Rupture of Membrane;   Fetal Growth Retardation;   Oligohydramnios;   Gestational Diabetes;   High Blood Pressure in Pregnancy
Intervention:   Device: Dilapan-S
Sponsors:   Medicem Technology s.r.o.;   The University of Texas Medical Branch, Galveston
Enrolling by invitation

Proton Pump Inhibitor Plus Propranolol Versus Proton Pump Inhibitor Alone on Peptic Ulcer Healing in Patients With Liver Cirrhosis

Conditions:   Liver Cirrhosis;   Peptic Ulcer
Interventions:   Drug: Proton-pump inhibitor;   Drug: Propranolol+Proton-pump inhibitor
Sponsor:   Taipei Veterans General Hospital, Taiwan
Terminated

Comparison of ONSD and rSO2 Measurements Between General and Spinal Anesthesia in C-Section

Condition:   Intracranial Pressure Increase
Intervention:   Other: Optic Nerve Sheath Diameter Measurement
Sponsor:   Bagcilar Training and Research Hospital
Active, not recruiting

Oral Etoposide Combined With Anlotinib in Advanced Triple Negative Breast Cancer

Condition:   Triple Negative Breast Cancer
Intervention:   Drug: oral etoposide + anlotinib
Sponsor:   Chinese Academy of Medical Sciences
Not yet recruiting

MRI Sequence and Imaging Protocol Development

Conditions:   Cardiomyopathy, Hypertrophic;   Cardiomyopathy, Dilated;   Left Ventricular Hypertrophy;   Ischemic Heart Disease;   Hypertension
Intervention:   Other: Cardiovascular Magnetic Resonance
Sponsor:   National Heart Centre Singapore
Recruiting

Diabetes Nutrition Algorithms in Patients With Overt Diabetes Mellitus

Conditions:   Type 2 Diabetes;   NAFLD;   Obesity;   Dyslipoproteinaemia;   Hypertension
Intervention:   Behavioral: dietary consulting and advise
Sponsors:   German Institute of Human Nutrition;   German Center for Diabetes Research;   California Walnut Company;   Institute for Cereal Processing GmbH/Institut für Getreideverarbeitung (IGV)
Recruiting

Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

Condition:   CAD
Interventions:   Device: MRI scan x 1 Healthy Volunteer;   Device: MRI scan x 2 Healthy Volunteer;   Device: MRI scan x 2 - CAD patients;   Device: MRI scan x 2- non CAD patients
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Preservative-free Tafluprost Eye Drops in Newly Diagnosed Patients With Glaucoma

Condition:   Glaucoma
Intervention:   Drug: Preservative-free tafluprost eye drops
Sponsor:   Alexandria University
Completed

Ab Interno Gelatin Stent With Mitomycin C Using Targeted Supra-tenon's Placement

Condition:   Glaucoma
Intervention:   Device: XEN-45 gelatin microstent
Sponsors:   Prism Eye Institute;   Allergan
Completed

Comparison of Topical Anesthesia and Analgosedation in Micropulse Transscleral Glaucoma Treatment

Condition:   Glaucoma
Intervention:   Device: Micropulse Transscleral Laser Therapy for Glaucoma (MP-TLT)
Sponsor:   University of Zurich
Recruiting

Subconjunctival Versus Direct Mitomycin C in Trabeculectomy

Condition:   Open Angle Glaucoma
Interventions:   Drug: Mitomycin-C injection;   Drug: Mitomycin-C sponge
Sponsor:   University of California, San Diego
Completed

hCT-MSCs for COVID19 ARDS

Conditions:   COVID;   Corona Virus Infection;   COVID19
Intervention:   Biological: human cord tissue mesenchymal stromal cells
Sponsors:   Joanne Kurtzberg, MD;   The Marcus Foundation
Recruiting

Preeclampsia-like Syndrome Induced by COVID-19: Is it a Real Public Health Issue in Pregnancy During the Pandemic?

Conditions:   Covid-19;   Preeclampsia;   Pregnancy Related
Intervention:   Diagnostic Test: PCR, lung ultrasound
Sponsor:   Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Recruiting

Lignocaine Nebulization for Attenuation of Intubation Stress Response

Condition:   Pressor Response
Interventions:   Drug: Lignocaine;   Drug: Placebo
Sponsor:   Assiut University
Not yet recruiting

Respiratory Rehabilitation in Obstructive Sleep Apneas

Conditions:   Sleep Disorder;   Sleep Apnea Syndromes
Interventions:   Behavioral: Myofunctional exercises;   Behavioral: The rules of sleep hygiene
Sponsors:   Università degli Studi 'G. d'Annunzio' Chieti e Pescara;   S. Spirito Hospital, Pescara, Italy
Enrolling by invitation

Study of Major Cardiovascular Events in Patients With Nonvalvular Atrial Fibrillation Treated With Rivaroxaban

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity

Conditions:   Obesity;   Metabolic Syndrome X
Interventions:   Drug: Metformin;   Drug: Orlistat;   Drug: Topiramate;   Drug: Placebo
Sponsor:   University of Iowa
Terminated

Post-marketing Surveillance of EVRENZO® Tablets (Roxadustat) in Dialysis-dependent Patients With Renal Anemia

Condition:   Renal Anemia
Intervention:   Drug: Roxadustat
Sponsor:   Astellas Pharma Inc
Recruiting

Efficacy and Safety Study of Hemay005 in Subjects With Moderate to Severe Plaque Psoriasis

Condition:   Psoriasis
Interventions:   Drug: 15mg Hemay005;   Drug: Placebos
Sponsor:   Tianjin Hemay Pharmaceutical Co.,Ltd
Active, not recruiting

Ocular Surface Disease Changes After iStent or iStent Inject Implantation With Phacoemulsification

Conditions:   Ocular Surface Disease;   Glaucoma, Open-Angle
Intervention:   Device: iStent or iStent inject implantation with concomitant cataract surgery
Sponsor:   Vance Thompson Vision
Completed

Development and Validation of a Model to Predict Fast Progression in Glaucoma

Conditions:   Glaucoma;   Primary Open Angle Glaucoma;   Glaucoma, Suspect
Intervention:   Diagnostic Test: Collection of genetic material
Sponsors:   Duke University;   Genentech, Inc.
Not yet recruiting

Safety and Efficacy Study of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) With or Without Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-7902-006/E7080-G000-315/LEAP-006)

Condition:   Nonsquamous Non-small Cell Lung Cancer
Interventions:   Biological: Pembrolizumab;   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Pemetrexed;   Drug: Lenvatinib;   Drug: Placebo matching lenvatinib
Sponsors:   Merck Sharp & Dohme Corp.;   Eisai Inc.
Recruiting

Gamification to Increase Mobility in the Hospital

Conditions:   Coronary Artery Disease;   Coronary Heart Disease;   Hypertension;   Diabete Mellitus;   Dyslipidemias;   Obesity;   Heart Failure
Intervention:   Behavioral: Gamification Intervention
Sponsor:   University of Pennsylvania
Not yet recruiting

A Safety and Efficacy Study of FCR001 vs Standard of Care in de Novo Living Donor Kidney Transplantation

Condition:   Transplanted Organ Rejection
Intervention:   Biological: FCR001
Sponsor:   Talaris Therapeutics Inc.
Recruiting

The European NAFLD Registry

Conditions:   NAFLD;   NASH;   NASH - Nonalcoholic Steatohepatitis;   Fibrosis, Liver;   Steatosis of Liver;   Hepatocellular Carcinoma;   Cardiovascular Diseases;   Type 2 Diabetes;   Dyslipidaemia;   Hypertension;   Obesity;   Other Associated Comorbidities
Intervention:  
Sponsors:   Newcastle University;   Newcastle-upon-Tyne Hospitals NHS Trust;   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA);   Institute of Cardiometabolism and Nutrition, France;   University of Cambridge;   Örebro University, Sweden;   University of Bern;   University of Oxford;   University of Turin, Italy;   University of Angers;   University Hospital, Antwerp;   Linkoeping University;   University of Helsinki;   UMC Utrecht;   National and Kapodistrian University of Athens;   University of Lisbon;   University of Milan;   University of Palermo;   Catholic University of the Sacred Heart;   Wuerzburg University Hospital;   RWTH Aachen University;   University of Nottingham;   Medical University of Vienna;   University of Birmingham;   University of Florence
Recruiting

Meta-analyses of the Effect of Important Food Sources of Sugars on Cardiometabolic Risk Factors

Conditions:   Dyslipidemia;   Diabetes;   Prediabetes;   Dysglycemia;   Gout;   Hypertension;   Non-alcoholic Fatty Liver Disease;   Cardiovascular Disease
Intervention:   Other: Fructose-containing Sugars
Sponsors:   University of Toronto;   Canadian Diabetes Association;   The Physicians' Services Incorporated Foundation;   Banting & Best Diabetes Centre
Active, not recruiting

A Study of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Evaluated as a Fixed Dose Combination Regimen in Participants Switching From an Integrase Inhibitor Who Have Experienced Rapid Weight Gain

Condition:   HIV-1
Interventions:   Drug: D/C/F/TAF FDC;   Drug: TAF/FTC FDC;   Drug: INI Based Regimen
Sponsor:   Janssen Scientific Affairs, LLC
Not yet recruiting

Pain Diabetic Peripheral Neuropathy(DPN) in China

Condition:   Diabetic Neuropathies
Intervention:   Other: Pain diabetic peripheral neuropathy
Sponsor:   Peking University Third Hospital
Completed

Effects of Behavioral Interventions on Weight Loss and Weight Maintenance

Condition:   Behavior
Intervention:   Behavioral: Behavioral interventions/modifications
Sponsor:   University of Pittsburgh
Withdrawn

Cardiac Arrest Incidence and Outcome Among Patients With COVID-19 in French ICUs

Conditions:   Sars-CoV2;   Covid-19
Interventions:   Other: Cardiopulmonary resuscitation;   Other: Modified Rankin score
Sponsor:   Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Recruiting

UrApp for Childhood Nephrotic Syndrome Management (Incident Cohort)

Condition:   Idiopathic Nephrotic Syndrome
Interventions:   Behavioral: Standard of Care;   Behavioral: UrApp
Sponsors:   Emory University;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

An International Pulmonary Embolism Registry Using EKOS

Condition:   Pulmonary Embolism and Thrombosis
Intervention:   Device: EkoSonic Endovascular System with thrombolytic
Sponsors:   EKOS Corporation;   BTG International Inc.
Recruiting

A Trial of Bardoxolone Methyl in Patients With ADPKD - FALCON

Conditions:   Autosomal Dominant Polycystic Kidney;   ADPKD
Interventions:   Drug: Bardoxolone methyl oral capsule;   Drug: Placebo oral capsule
Sponsor:   Reata Pharmaceuticals, Inc.
Recruiting

Biological Markers of Disease in the Prediction of Preterm Delivery, Preeclampsia and Intra-Uterine Growth Retardation: A Longtitudinal Study

Conditions:   Prenatal Care;   Premature Birth
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed

Evaluation of Patients With Liver Disease

Conditions:   Biliary Liver Cirrhosis;   Hemochromatosis;   Hepatitis;   Hepatolenticular Degeneration;   Liver Disease
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Integrating Risk-based Care for Patients With CKD

Condition:   Chronic Kidney Disease
Intervention:   Other: Active Knowledge Translation
Sponsors:   University of Manitoba;   Canadian Primary Care Sentinel Surveillance Network;   Canadians Seeking Solutions and Innovations to Overcome Chronic Kidney Disease;   Manitoba Primary Care Research Network (MaPCReN);   Southern Alberta Primary Care Research Network (SAPCReN)
Recruiting

HIV-HEART Aging Study (15 Year Follow up)

Conditions:   HIV Infections;   Coronary Disease;   Myocardial Infarction;   HIV Encephalopathy;   Aging;   Heart Failure;   Weight Gain
Intervention:  
Sponsor:   University Hospital, Essen
Recruiting

Effect of Glycopyrrolate on Vasopressors Requirement for Non-elective Caesarean Section Under Spinal Anaesthesia

Conditions:   Glycopyrrolate;   Post-spinal Hypotension;   Effect of Drug;   Hemodynamic Instability
Interventions:   Drug: Glycopyrrolate 0.2 MG/ML;   Drug: Normal saline
Sponsor:   Rajesh Deshar
Recruiting

Chart Review: Drug Utilization Study in Participants Who Received Ozurdex™ (Dexamethasone Intravitreal Implant) 0.7 mg Injections for Visual Impairment Due to Diabetic Macular Edema (DME)

Condition:   Diabetic Macular Edema
Intervention:   Drug: Dexamethasone intravitreal implant
Sponsor:   Allergan
Completed

A Study to Evaluate PF-06730512 in Adults With Focal Segmental Glomerulosclerosis (FSGS)

Condition:   Focal Segmental Glomerulosclerosis (FSGS)
Intervention:   Drug: PF-06730512
Sponsor:   Pfizer
Recruiting

Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE)

Condition:   Asthma
Intervention:  
Sponsors:   AstraZeneca;   Parexel;   MedImmune LLC
Recruiting

Effects of Message Framing and Time Discounting on Health Communication for Optimum Cardiovascular Disease and Stroke Prevention

Conditions:   Cardiovascular Disease;   Stroke;   Primary Prevention
Intervention:   Other: The strategic use of messages in risk communication
Sponsors:   West China Hospital;   Centers for Disease Control and Prevention, China;   Beijing Tiantan Hospital;   First Affiliated Hospital of Chongqing Medical University;   China Stroke Databank Center
Not yet recruiting

Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial)

Condition:   Critical Illness
Interventions:   Drug: Dexmedetomidine;   Drug: Clonidine;   Drug: Propofol
Sponsors:   University of Edinburgh;   West Hertfordshire Hospitals NHS Trust;   Queen's University, Belfast;   The University of Queensland;   University Hospital of Wales;   Edinburgh Napier University;   King's College London;   University of Warwick;   University of Manchester;   Royal Surrey County Hospital NHS Foundation Trust;   University College, London;   NHS Lothian;   Imperial College London;   University of Cambridge
Recruiting

Study of New Imaging Criteria for the Diagnosis of Caroli's Disease

Conditions:   Caroli Disease;   Magnetic Resonance Imaging;   Cholangiopancreatography
Intervention:   Diagnostic Test: Magnetic Resonance CholangioPancreatography
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting

Research Study Comparing Insulin Degludec to Insulin Detemir, Together With Insulin Aspart, in Pregnant Women With Type 1 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 1
Interventions:   Drug: Insulin degludec;   Drug: Insulin Aspart;   Drug: Insulin detemir
Sponsor:   Novo Nordisk A/S
Active, not recruiting

Belatacept Early Steroid Withdrawal Trial

Condition:   Renal Transplantation
Interventions:   Drug: Alemtuzumab;   Drug: rabbit antithymocyte globulin;   Drug: Belatacept;   Drug: Tacrolimus;   Drug: Mycophenolate mofetil;   Drug: early cessation of steroids
Sponsor:   University of Cincinnati
Completed

Ascertain the Optimal Starting Dose of Mircera Given Subcutaneously for Maintenance Treatment of Anemia in Pediatric Patients With Chronic Kidney Disease on Dialysis or Not Yet on Dialysis.

Conditions:   Anemia;   Renal Insufficiency, Chronic
Intervention:   Drug: Mircera
Sponsor:   Hoffmann-La Roche
Recruiting

INTERCOMEX Donor-Derived Cell Free DNA Study

Condition:   Kidney Transplant Rejection
Interventions:   Diagnostic Test: MMDx;   Diagnostic Test: Prospera;   Diagnostic Test: HLA antibody
Sponsors:   University of Alberta;   Natera, Inc.;   One Lambda
Recruiting

Efficacy and Safety of Lucerastat Oral Monotherapy in Adult Subjects With Fabry Disease

Condition:   Fabry Disease
Interventions:   Drug: Lucerastat;   Drug: Placebo
Sponsor:   Idorsia Pharmaceuticals Ltd.
Recruiting

The Efficacy of a 6-point Transscleral Suture Fixation of a 3-looped Haptics PC-IOL Implantation Through Scleral Pockets for Surgical Management for Microspherophakia

Condition:   Microspherophakia
Intervention:  
Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University
Completed

Adipokines, Inflammation, Insulin Resistance and Endothelial Dysfunction in Preeclampsia

Condition:   Pre-Eclampsia
Interventions:   Diagnostic Test: Serum asymmetteric dimethyl arginine;   Diagnostic Test: serum lipid profiles;   Diagnostic Test: Serum vaspin;   Diagnostic Test: Serum resistin
Sponsor:   Tanta University
Completed

Intensive Management of At-risk Patients

Condition:   Chronic Disease
Interventions:   Behavioral: Intensive management;   Behavioral: Control
Sponsor:   CareMore Health, San Bernardino
Not yet recruiting

Goals for Reaching Optimal Wellness: GROWell

Conditions:   Pregnancy Related;   Gestational Weight Gain;   Postpartum Weight Retention;   Overweight and Obesity
Intervention:   Behavioral: Personalized Digital Health Support for Pregnancy and Postpartum Behavior Change
Sponsors:   University of California, Davis;   Duke University;   Pattern Health;   National Institute of Nursing Research (NINR)
Not yet recruiting

Strengthening Maternal Neonatal and Child Health Services in a Rural District of Pakistan

Conditions:   Antepartum Hemorrhage;   Postpartum Hemorrhage;   Anemia;   Eclampsia;   Neonatal Sepsis;   Birth Asphyxia;   Diarrhoea;   Pneumonia
Intervention:   Other: Maternal Neonatal and Child Health Interventions
Sponsors:   Aga Khan University;   The International Federation of Red Cross and Red Crescent Societies
Completed