High Blood Pressure

Clinical Trial Finder

Many patients with high blood pressure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Potatoes, Hypertension RIsk and Endothelial Function Study

Condition:   Endothelial Dysfunction
Interventions:   Other: Potato;   Other: Non-starchy vegetable
Sponsor:   Brigham and Women's Hospital
Not yet recruiting - verified April 2017

The Feasibility of a Web-based Application to Monitor Home Blood Pressure

Condition:   Hypertension
Intervention:   Other: Direct input of home blood pressure readings via MyChart
Sponsor:   Loyola University
Enrolling by invitation - verified April 2017

ACEI/ARB Study in Ambulatory and Day of Surgery Admission Patients

Conditions:   Hypertension;   Hypotension
Intervention:   Drug: ACEI or ARB
Sponsor:   State University of New York - Downstate Medical Center
Terminated - verified April 2017

VentaProst Versus Conventionally-Administered Aerosolized Epoprostenol in Patients Undergoing Cardiac Surgery With CPB

Condition:   Pulmonary Hypertension
Intervention:   Combination Product: VentaProst
Sponsor:   Aerogen Pharma Limited
Not yet recruiting - verified April 2017

Quantitative Renal Uptake Using TC99m DMSA in Hypertensive &/or Diabetic Patients.

Conditions:   Diabetes Mellitus;   Hypertension
Intervention:   Diagnostic Test: DMSA scan
Sponsor:   Assiut University
Recruiting - verified April 2017

Social Deprivation and Pregnancy

Conditions:   Gestational Diabetes;   High Blood Pressure;   Prematurity;   Fetal Growth Restriction
Intervention:   Other: Epices score
Sponsor:   University Hospital, Clermont-Ferrand
Not yet recruiting - verified April 2017

Clinical Trial to Compare the Safety and Pharmacokinetics of YHP1604 in Comparison to the Co-administration of Telmisartan/Amlodipine and Rosuvastatin

Conditions:   Hypertension;   Hyperlipidemia
Interventions:   Drug: Temisartan+Amlodipine+Rosuvastatin;   Drug: YHP1604
Sponsor:   Yuhan Corporation
Not yet recruiting - verified April 2017

Our Anesthesia Experience During MRI Scan

Conditions:   Epileptic Seizure;   Intracranial Tumor;   Intracranial Hypertension;   Intracranial Aneurysm;   Vertebra; Anomaly
Intervention:  
Sponsor:   Akdeniz University
Not yet recruiting - verified April 2017

Central Hemodynamic Exercise Responses Study

Conditions:   Exercise;   Central Blood Pressure
Interventions:   Other: Aerobic Interval Exercise;   Other: Continuous exercise
Sponsor:   Arizona State University
Recruiting - verified April 2017

Post-Exercise Hypotension After Water Exercise

Condition:   Postexercise Hypotension
Intervention:   Other: Water aerobic exercise session (WATER)
Sponsor:   Instituto de Cardiologia do Rio Grande do Sul
Recruiting - verified April 2017

Individualized Cognitive Training in HIV

Conditions:   HIV-Associated Cognitive Motor Complex;   Aging;   Cognitive Impairment;   Cognitive Decline;   Attention Impaired;   Processing, Visual Spatial;   Cognitive Deficit in Attention;   Cognitive Disorder in Remission
Interventions:   Behavioral: Individualized Cognitive Training;   Other: No-Contact Control
Sponsors:   University of Alabama at Birmingham;   National Institute of Nursing Research (NINR)
Not yet recruiting - verified April 2017

Economic Crisis and Adherence to the Mediterranean Diet (CASSIOPEA)

Conditions:   Dietary Habits;   Inflammation;   Economic Problems;   Obesity;   Diabetes;   Hypertension
Intervention:  
Sponsor:   Neuromed IRCCS
Not yet recruiting - verified April 2017

Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System

Conditions:   Anxiety;   Hypertension
Interventions:   Drug: Clonidine Pill;   Drug: Hydrochlorothiazide
Sponsor:   University of Iowa
Recruiting - verified April 2017

Assessment of Heparin Binding Protein for the Prediction of Severe Sepsis

Conditions:   Sepsis;   Septic Shock;   Sepsis With Acute Organ Dysfunction
Intervention:  
Sponsors:   Axis Shield Diagnostics Ltd;   Drexel University;   York Hospitals;   Jefferson Medical College of Thomas Jefferson University
Not yet recruiting - verified April 2017

Postural Changes During Right Heart Catheterization

Conditions:   Pulmonary Hypertension;   Right Heart Failure Due to Pulmonary Hypertension
Intervention:   Diagnostic Test: Right heart catheterization
Sponsor:   University of North Carolina, Chapel Hill
Not yet recruiting - verified March 2017

Communicating Health Information and Improving Coordination With Primary Care

Conditions:   Hypertension;   Dyslipidemias;   Diabetes;   Childhood Cancer
Interventions:   Behavioral: Education;   Behavioral: Test results only
Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI);   St. Jude Children's Research Hospital
Enrolling by invitation - verified April 2017

Quantitative MRI for Non-invasive Assessment of Severity of Alcoholic Liver Disease (ALD)

Condition:   Alcoholic Liver Disease
Intervention:   Radiation: MRI
Sponsor:   The Cleveland Clinic
Recruiting - verified April 2017

Withings Pulse Wave Velocity and Blood Pressure Study

Conditions:   Elevated Blood Pressure;   Hypertension;   Mental Stress;   Sleep Disorders
Intervention:  
Sponsors:   Scripps Translational Science Institute;   Withings
Active, not recruiting - verified March 2017

Novel Markers for Detecting Early Progression of Glaucoma

Condition:   Glaucoma
Intervention:   Diagnostic Test: Optical Coherence tomography angiography
Sponsor:   Balwantray Chauhan
Not yet recruiting - verified April 2017

The Interest of the ANI in the Monitoring of Peroperative Analgesia in Bariatric Surgery

Conditions:   Surgery;   Obese
Interventions:   Device: To demonstrate the monitoring of perioperative analgesia;   Other: Standard preoperative evaluation of analgesia
Sponsor:   Centre Hospitalier Universitaire, Amiens
Recruiting - verified April 2017

The Effects of Renin Inhibition on Fibrinolytic Balance and Endothelial Function

Condition:   High Blood Pressure
Interventions:   Drug: Aliskiren;   Drug: Placebo;   Drug: Hydrochlorothiazide
Sponsor:   Vanderbilt University
Completed - verified April 2017

Safety and Efficacy of Simultaneous or Staged Surgery on Complicated Hepatolithiasis

Condition:   Hepatolithiasis
Interventions:   Procedure: Simultaneous surgery;   Procedure: staged surgery
Sponsors:   Southwest Hospital, China;   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Chinese PLA General Hospital;   Eastern Hepatobiliary Surgery Hospital;   First Affiliated Hospital of Zhongshan Medical University;   Fourth Military Medical University;   Huaxi Hospital;   Tongji Hospital;   Union hospital of Fujian Medical University
Recruiting - verified April 2017

Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose

Conditions:   Sickle Cell Anemia;   Sickle Cell Disease
Intervention:  
Sponsors:   Cardiologie et Développement;   Institut National de la Santé Et de la Recherche Médicale, France;   University of Paris 5 - Rene Descartes;   laboratory of excellence GR-Ex
Recruiting - verified April 2017

Screening for COPD in Primary Care: a Synergistic Approach - Dentists - Pharmacists -Physiotherapists - Nurses - Physicians

Condition:   COPD
Intervention:   Diagnostic Test: COPD screening
Sponsor:   University Hospital, Brest
Active, not recruiting - verified April 2017

Acute-phase Response & Periodontal Treatment in Patients With Hypertension

Conditions:   Periodontitis;   Hypertension
Interventions:   Procedure: FM-SRP;   Procedure: Q-SRP
Sponsor:   University of Pisa
Recruiting - verified April 2017

Trial of IW-1973, A Stimulator of Soluble Guanylate Cyclase (sGC) in Patients With Stable Type 2 Diabetes and Hypertension

Conditions:   Diabetes Mellitus, Type 2;   Hypertension
Interventions:   Drug: IW-1973 Oral Tablet;   Drug: IW-1973 Oral Tablet;   Drug: Placebo Oral Tablet
Sponsor:   Ironwood Pharmaceuticals, Inc.
Recruiting - verified April 2017

Safety and Efficacy of Twelve Hours Duration of MgSO4 in the Treatment of Eclampsia in Low Resource Setting in Sudan

Condition:   Pre-Eclampsia
Intervention:   Drug: Adminstration of magnesium Sulphate for treatment of eclampsia
Sponsor:   Gadarif University
Enrolling by invitation - verified April 2017

Predictors and Prognostic Factors on the Acute Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: Drug Therapy;   Diagnostic Test: Routine Blood Test and Image Scan;   Other: Intravascular therapy;   Other: Emergency Treatment;   Other: Medical history
Sponsor:   Tongji Hospital
Not yet recruiting - verified April 2017

Use of Impedance Cardiography to Decrease the Risk of Pre-eclampsia in Obese Patients

Conditions:   Obesity, Morbid;   Preeclampsia
Interventions:   Drug: Labetalol Hydrochloride 200 mg;   Drug: NIFEdipine 60 mg;   Drug: Atenolol 25 mg
Sponsor:   University of Tennessee Graduate School of Medicine
Recruiting - verified April 2017

Extended Access Program to Assess Long-term Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension RANGER

Condition:   Pulmonary Hypertension
Intervention:   Drug: Bardoxolone methyl
Sponsor:   Reata Pharmaceuticals, Inc.
Recruiting - verified April 2017

Aerobic Interval Training in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Hypoxemia

Conditions:   Pulmonary Disease, Chronic Obstructive;   Hypertension, Pulmonary;   Hypoxia
Intervention:   Other: Exercise
Sponsors:   Norwegian University of Science and Technology;   St. Olavs Hospital
Recruiting - verified April 2017

Hypertension in Long-Term Care Facilities

Condition:   Hypertension
Intervention:   Other: Chart review
Sponsor:   Louisiana State University Health Sciences Center in New Orleans
Recruiting - verified April 2017

Clinical Trial of Temisartan/Amlodipine & Rosuvastatin in Subjects With Hypertension and Hyperlipidemia

Conditions:   Hypertension;   Hyperlipidemia
Interventions:   Drug: Temisartan+Amlodipine+Rosuvastatin (Combination drug);   Drug: Temisartan+Amlodipine;   Drug: Temisartan+Rosuvastatin
Sponsor:   Yuhan Corporation
Recruiting - verified April 2017

Genetic Determinants of ACEI Prodrug Activation

Condition:   Healthy Volunteers
Intervention:   Drug: Enalapril
Sponsor:   University of Michigan
Recruiting - verified April 2017

Clinical Characteristics, Anti-hyperglycaemic Treatment Pattern and Target Attainment of Type 2 Diabetes Mellitus Patients in Older Population With or Without Albuminuria in China

Condition:   Type 2 Diabetes Mellitus
Intervention:   Drug: No Treatment
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2017

Platelet Transfusion During Neonatal Open Heart Surgery

Conditions:   Cardiac Disease;   Cardiac Surgery;   Cardiopulmonary Bypass;   Platelet Transfusion;   Arrythmia, Cardiac;   Mortality
Interventions:   Biological: Platelet Transfusion;   Biological: FFP and Cryoprecipitate;   Biological: PRBC and cell saver Transfusion;   Biological: Factor Concentrate (Bebulin)
Sponsor:   The University of Texas Health Science Center, Houston
Recruiting - verified April 2017

To Evaluate Real-world Safety, Effectiveness and Appropriate Use of Micatrio® Combination Tablets Treatment in Patients With Hypertension

Condition:   Hypertension
Intervention:   Drug: T80/A5/H12.5 FDC
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2017

Can MRI Evaluate Beta-blocker Response in Portal Hypertension?

Conditions:   Liver Cirrhosis;   Portal Hypertension;   Varix, Esophageal
Interventions:   Drug: Carvedilol;   Other: MRI scan;   Procedure: Hepatic Venous Pressure Gradient (HVPG)
Sponsors:   University of Nottingham;   Derby Hospitals NHS Foundation Trust;   Nottingham University Hospitals NHS Trust
Recruiting - verified April 2017

Retrospective Review of NSAIDS in the Postpartum Period

Condition:   Post Partum Pain
Intervention:   Other: NSAID use
Sponsor:   St. Louis University
Enrolling by invitation - verified April 2017

Emotional Awareness and SElf-regulation for Depression in Patients With Hypertension (EASE) Study

Condition:   Hypertension
Interventions:   Behavioral: UPLIFT;   Behavioral: Usual care
Sponsor:   New York University School of Medicine
Recruiting - verified April 2017

Investigating Idiopathic Pulmonary Fibrosis in Greece (INDULGE IPF)

Condition:   Idiopathic Pulmonary Fibrosis
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2017

Melatonin in Pregnancy Compared to Non-pregnant

Condition:   Pregnancy Transient Hypertension
Intervention:  
Sponsors:   University of Aberdeen;   NHS Grampian
Active, not recruiting - verified January 2017

Validation of Predictors of OAC Initiation Using EMR Data

Condition:   Atrial Fibrillation
Interventions:   Drug: Dabigatran etexilate;   Drug: Warfarin
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2017

Piloting Healthcare Coordination in Hypertension

Condition:   Hypertension
Intervention:   Device: optima4BP medication optimization
Sponsors:   Optima Integrated Health;   University of California, San Francisco
Completed - verified December 2016

Study of the Efficacy and Safety of DigiFab® in Antepartum Subjects With Severe Preeclampsia

Condition:   Severe Preeclampsia
Interventions:   Biological: Digoxin immune fab;   Other: Placebo
Sponsor:   Velo Bio, LLC
Recruiting - verified April 2017

Medication Adherence in Hypertensive Individuals With Bipolar Disorder

Conditions:   Hypertension;   Bipolar Disorder
Interventions:   Behavioral: iTAB-CV Stage 2;   Behavioral: iTAB-CV Stage 1
Sponsor:   Case Western Reserve University
Recruiting - verified April 2017

The Femtosecond Laser in Residency Training (FLIRT) Pilot Study

Conditions:   Cataract;   Intraocular Lens Implantation
Interventions:   Procedure: FLA-CEIOL;   Procedure: CEIOL
Sponsors:   University of Southern California;   Alcon Research
Not yet recruiting - verified April 2017

NSAID Use in Postpartum Hypertensive Women

Condition:   Hypertension
Interventions:   Drug: Acetaminophen;   Drug: NSAID
Sponsor:   St. Louis University
Enrolling by invitation - verified April 2017

Risk Reduction for Alzheimer's Disease

Conditions:   Cognitively Normal Older Adults;   Hypertension;   Subjective Cognitive Decline;   Family History of Alzheimer's Disease
Interventions:   Drug: Angiotensin II receptor blocker (ARB, losartan) and calcium channel blocker (CCB, amlodipine);   Behavioral: Aerobic Exercise Training;   Other: Usual Care;   Behavioral: Stretching Exercise;   Drug: Atorvastatin
Sponsors:   University of Texas Southwestern Medical Center;   Texas Health Resources;   University of Kansas Medical Center;   Washington University School of Medicine;   Pennington Biomedical Research Center;   Michigan State University
Recruiting - verified April 2017

Proof-of-Concept Trial on Selective Removal of sFlt-1 in Pregnant Women With Preeclampsia Via Apheresis

Condition:   Preeclampsia
Intervention:   Device: TheraSorb sFlt-1 adsorber
Sponsors:   Miltenyi Biotec GmbH;   Cromsource
Recruiting - verified April 2017

Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Adempas (Riociguat, BAY63-2521);   Drug: Sildenafil;   Drug: Tadalafil
Sponsor:   Bayer
Recruiting - verified April 2017

Accuracy of Zero Heat Flux Cutaneous Temperature in Intensive Care Adults

Conditions:   Continuous Non Invasive Cutaneous Temperature;   Zero Heat Flux Method;   Esophageal Temperature;   Arterial Temperature;   Intracerebral Temperature
Interventions:   Procedure: temperature obtained by the non-invasive method of zero-heat flux;   Procedure: esophageal temperature;   Procedure: intracerebral temperature;   Procedure: arterial temperature
Sponsor:   Poitiers University Hospital
Recruiting - verified September 2016

Astronaut Vision Issues in a Ground Analog Population: Polycystic Ovary Syndrome

Conditions:   Polycystic Ovarian Syndrome;   Idiopathic Intracranial Hypertension
Intervention:  
Sponsors:   National Aeronautics and Space Administration (NASA);   University of Texas;   Mayo Clinic;   University of Florida;   University of North Carolina;   Coastal Eye Associates
Recruiting - verified April 2017

Study of Fixed-Dose Combinations of Trabodenoson and Latanoprost in Adults With Ocular Hypertension or Primary Open-Angle Glaucoma

Conditions:   Primary Open-Angle Glaucoma (POAG);   Ocular Hypertension (OHT)
Interventions:   Drug: trabodenoson 6.0% / latanoprost 0.005% QD;   Drug: trabodenoson 3.0% / latanoprost 0.005% QD;   Drug: trabodenoson 6.0% / latanoprost 0.0025% QD;   Drug: latanoprost 0.005% QD;   Drug: latanoprost 0.0025% QD
Sponsor:   Inotek Pharmaceuticals Corporation
Active, not recruiting - verified April 2017

Spinal Cord Stimulation to Treat Hypertension

Condition:   Hypertension
Intervention:   Device: Precision Spectra System
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Recruiting - verified April 2017

Non-interventional, Postauthorization Safety Study of Ventavis for Pulmonary Arterial Hypertension (PAH)

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Ventavis (Iloprost, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified April 2017

Southeastern Collaboration to Improve Blood Pressure Control

Condition:   Hypertension
Interventions:   Behavioral: Practice Facilitation;   Behavioral: Peer Coach;   Behavioral: Enhanced usual care
Sponsor:   University of Alabama at Birmingham
Not yet recruiting - verified April 2017

Apalutamide Plus Intermittent Hormone Therapy Versus Intermittent Hormone Therapy Alone in Prostate Cancer

Condition:   Prostate Cancer
Interventions:   Drug: Apalutamide;   Drug: IHT
Sponsors:   Robert J Amato;   Janssen Scientific Affairs, LLC
Not yet recruiting - verified April 2017

Study to Evaluate CORT125134 in Patients With Cushing's Syndrome

Condition:   Cushing's Syndrome
Intervention:   Drug: CORT125134
Sponsor:   Corcept Therapeutics
Recruiting - verified April 2017

Innovative Multigenerational Household Intervention to Reduce Stroke and CVD

Conditions:   Stroke;   Cardiovascular Disease
Interventions:   Behavioral: Motivational Interviewing Intervention Arm;   Other: Control Brochure Arm
Sponsor:   Washington State University
Active, not recruiting - verified April 2017

Open-label, Single Arm Trial of BI 695502 in Patients With Previously Untreated Metastatic Colorectal Cancer

Condition:   Colorectal Neoplasms
Interventions:   Drug: BI 695502;   Drug: chemotherapy
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2017

A Long-term Extension Study of Riociguat in Patients With Symptomatic Pulmonary Arterial Hypertension.

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Adempas (Riociguat, BAY63-2521)
Sponsor:   Bayer
Recruiting - verified April 2017

Families on Track: A Digital Health Behavioral Intervention for Parents Seeking Treatment for Their Child With Obesity

Conditions:   Obesity;   Childhood Obesity;   Hypertension;   Diabetes;   Dyslipidemia
Intervention:   Behavioral: Families on Track Intervention
Sponsor:   Duke University
Recruiting - verified April 2017

Taxi METERS: Measuring Effectiveness of Technology, Education, Referrals and Support

Condition:   Improving Blood Pressure Control
Interventions:   Other: CONTROL- Usual & Customary Health Fair Follow-up;   Other: Health Fair + TECH [Text Messaging + Home Blood Pressure Monitoring];   Other: Heal th Fair + TECH [Text Messaging + Home Blood Pressure Monitoring] + Social Network Support (SNS)
Sponsor:   Memorial Sloan Kettering Cancer Center
Enrolling by invitation - verified April 2017

WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study)

Conditions:   Williams Syndrome;   Cardiovascular Disease;   Multisystem Developmental Disorder;   Elastin Gene Deletion;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 4, 2017

Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension - CATALYST

Condition:   Connective Tissue Disease-Associated Pulmonary Arterial Hypertension
Interventions:   Drug: Placebo capsules;   Drug: Bardoxolone methyl capsules
Sponsor:   Reata Pharmaceuticals, Inc.
Recruiting - verified April 2017

Hemodynamic Changes and Vascular Tone Control After Bariatric Surgery

Condition:   Systemic Vascular Resistance
Intervention:  
Sponsor:   Parc de Salut Mar
Recruiting - verified September 2016

Phase II Study of Perindopril and Regorafenib in mCRC

Condition:   Metastatic Colorectal Cancer
Interventions:   Drug: Regorafenib;   Drug: Perindopril
Sponsors:   British Columbia Cancer Agency;   Bayer
Recruiting - verified April 2017

A Therapeutic Open Label Study of Tocilizumab in the Treatment of Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Tocilizumab
Sponsors:   Papworth Hospital NHS Foundation Trust;   Roche Pharma AG;   National Institute for Health Research, United Kingdom
Recruiting - verified April 2017

An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease;   Combined Pulmonary Fibrosis and Emphysema
Intervention:   Drug: Inhaled Treprostinil
Sponsor:   United Therapeutics
Enrolling by invitation - verified April 2017

Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE

Conditions:   Pulmonary Hypertension;   Interstitial Lung Disease;   Combined Pulmonary Fibrosis and Emphysema
Interventions:   Drug: Inhaled Treprostinil;   Drug: Placebo
Sponsor:   United Therapeutics
Recruiting - verified April 2017

A Study Investigating Routine Practice of Chronic Thromboembolic Pulmonary Hypertension Management in EMEA Countries

Condition:   Hypertension, Pulmonary
Intervention:   Other: Standard of care
Sponsor:   Bayer
Recruiting - verified April 2017

Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer

Conditions:   Breast Carcinoma;   Hypertension
Intervention:   Other: Laboratory Biomarker Analysis
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified April 2017

The Safety and Efficacy of Dapagliflozin Therapy in Combination With Insulin in Japanese Subjects With Type 1 Diabetes Mellitus (T1DM)

Condition:   Type 1 Diabetes Mellitus
Interventions:   Drug: Dapagliflozin 5 mg;   Drug: Dapagliflozin 10mg
Sponsor:   AstraZeneca
Active, not recruiting - verified April 2017

Improving Chronic Disease Management With Pieces

Conditions:   Chronic Kidney Disease;   Diabetes;   Hypertension;   High BP;   Type 2 Diabetes
Intervention:   Other: Collaborative Model of Primary care and Subspecialty care
Sponsors:   University of Texas Southwestern Medical Center;   Parkland Center for Clinical Innovation;   Parkland Health & Hospital System;   Texas Health Resources;   Connecticut Center for Primary Care;   Dallas VA Research Corporation;   G-Health Enterprises
Recruiting - verified April 2017

Atorvastatin Effectiveness and Safety in Cardiology Patients in Real World Setting

Condition:   Coronary Artery Disease, Hypercholesterolemia, Hypertension
Intervention:   Other: No intervention
Sponsor:   Pfizer
Recruiting - verified April 2017

Egypt Hypertension Study

Condition:   Different Classes of the Antihypertensive Treatment
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified April 2017

The Effect of Blood Pressure on Cerebral Perfusion During Vascular Surgery

Conditions:   Anesthesia;   Peripheral Arterial Diseases
Interventions:   Other: MAP maintained at 80 mmHg;   Other: MAP maintained at 60 mmHg
Sponsor:   Rigshospitalet, Denmark
Withdrawn - verified April 2017

Operative Procedures vs. Endovascular Neurosurgery for Untreated Pseudotumor Trial

Conditions:   Pseudotumor Cerebri;   Idiopathic Intracranial Hypertension (IIH)
Interventions:   Device: Dural Venous Sinus Stenting;   Device: Cerebrospinal Fluid Shunting
Sponsor:   St. Joseph's Hospital and Medical Center, Phoenix
Not yet recruiting - verified April 2017

Optic Nerve Sheath Diameter and Intracranial Pressure (ICP) in Children

Condition:   Intracranial Hypertension
Intervention:   Procedure: ultrasound
Sponsor:   Anna Rominger
Not yet recruiting - verified April 2017

TAK-491 (Azilsartan Medoxomil) Compared to Valsartan in Chinese Participants With Hypertension

Condition:   Essential Hypertension
Interventions:   Drug: Azilsartan medoxomil;   Drug: Valsartan;   Drug: Azilsartan medoxomil Placebo;   Drug: Valsartan Placebo
Sponsor:   Takeda
Recruiting - verified April 2017

TIPS vs Endoscopic Therapy for Variceal Rebleeding in Cirrhotic Patients With Portal Vein Thrombosis

Conditions:   Portal Vein Thrombosis;   Liver Cirrhosis
Interventions:   Procedure: Transjugular intrahepatic portosystemic shunt;   Drug: Non-selective beta blockers;   Procedure: Endoscopic therapy;   Drug: Anticoagulation
Sponsor:   Fourth Military Medical University
Not yet recruiting - verified April 2017

The Efficacy and Safety of OROSARTAN® Versus CODIOVAN® in Patients With Essential Hypertension Uncontrolled With Monotherapy

Condition:   Hypertension
Interventions:   Drug: OROSARTAN® 5/160mg;   Drug: CODIOVAN® 160/12.5mg
Sponsor:   Dong-A ST Co., Ltd.
Completed - verified April 2017

SPYRAL HTN-ON MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Recruiting - verified April 2017

SPYRAL HTN-OFF MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Recruiting - verified April 2017

Natural History of Noncirrhotic Portal Hypertension

Conditions:   Cystic Fibrosis;   Immunologic Deficiency Syndrome;   Turner Syndrome;   Congenital Hepatic Fibrosis;   Idiopathic Non-Cirrhotic Portal Hypertension
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 4, 2017

Reprogramming Insoles In Regulating Blood Pressure In Hypertensive Subjects

Condition:   Hypertension
Intervention:   Device: Reprogramming insoles
Sponsor:   Escola Bahiana de Medicina e Saude Publica
Recruiting - verified April 2017

Effects of Tart Cherry and Aroniaberry Supplementation on Endothelial Function and Cardiovascular Measures in Healthy Older Adults: Interactions With Genotype and Proteome

Conditions:   Cardiovascular Disease;   Coronary Heart Disease;   Aging
Intervention:  
Sponsor:   National Institute of Nursing Research (NINR)
Recruiting - verified November 2, 2016

Macronutrient Effects on Alzheimer's Disease (MEAL-2)

Conditions:   Prediabetic State;   Insulin Resistance;   Middle Age;   Prehypertension;   Mild Cognitive Impairment
Interventions:   Other: Low Diet;   Other: High Diet
Sponsor:   Wake Forest University Health Sciences
Completed - verified April 2017

Improving Mental Health Through Integration With Primary Care in Rural Karnataka

Conditions:   Chronic Disease;   Depression;   Anxiety
Intervention:   Behavioral: Healthy Living Intervention
Sponsors:   University of California, San Francisco;   National Institute of Mental Health (NIMH)
Recruiting - verified April 2017

REACH OUT: to Reduce High Blood Pressure in the Emergency Department

Conditions:   Hypertension;   Stroke
Intervention:   Behavioral: Text messaging
Sponsor:   University of Michigan
Completed - verified April 2017

Mexican Registry of Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:  
Sponsors:   Remehip;   Bayer;   Medicaweb, S.A.C.V.
Enrolling by invitation - verified April 2017

Phase III Trial BI 695502 Plus Chemotherapy vs. Avastin® Plus Chemotherapy in Patients With Lung Cancer

Condition:   Carcinoma, Non-Small-Cell Lung
Interventions:   Drug: Chemotherapy;   Drug: BI 695502;   Drug: bevacizumab;   Drug: Chemotherapy
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2017

Early Rheumatoid Arthritis COR Intervention

Conditions:   Rheumatoid Arthritis;   Cardiovascular Diseases
Interventions:   Other: Simvastatin;   Other: Losartan;   Other: Losartan;   Other: Losartan;   Other: Metformin;   Other: Outpatient rheumatology department;   Other: Refered to general practice
Sponsor:   MD, PhD, Annemarie Lyng Svensson
Recruiting - verified April 2017

Alcon Ex-PRESS™ Glaucoma Filtration Device in Japanese Patients

Condition:   Glaucoma
Intervention:   Device: Ex-PRESS™ Glaucoma Filtration Device, Model P50PL
Sponsor:   Alcon Research
Completed - verified April 2017

24 Week Efficacy and Safety Study of Empagliflozin (BI 10773) in Hypertensive Black/African American Patients With Type 2 Diabetes Mellitus and Hypertension

Conditions:   Diabetes Mellitus, Type 2;   Hypertension
Interventions:   Drug: Empagliflizon low dose;   Drug: placebo;   Drug: Empagliflizon high dose
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified April 2017

A Phase 1/2 Multicenter, Randomized, Study to Evaluate the Safety and Efficacy of VS101 Subconjunctival Latanoprost Insert in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Conditions:   Open Angle Glaucoma;   Ocular Hypertension
Interventions:   Drug: VS101 Insert Dose A;   Drug: VS101 Insert Dose B;   Drug: VS101 Insert Dose C;   Drug: Latanoprost 0.005% eye drops
Sponsor:   ViSci Ltd.
Active, not recruiting - verified October 2016

Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH )

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat (ADEMPAS, BAY63-2521)
Sponsor:   Bayer
Recruiting - verified April 2017

Extension of the Psychometric Validation Study ORCHESTRA in Patients With PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Macitentan
Sponsor:   Actelion
Active, not recruiting - verified April 2017

EXPERT, EXPosurE Registry RiociguaT in Patients With Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Intervention:   Drug: Riociguat(BAY63-2521)
Sponsor:   Bayer
Recruiting - verified April 2017

A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients

Conditions:   Heart Failure;   Respiratory Insufficiency;   Stroke Acute;   Infectious Diseases;   Rheumatic Diseases
Interventions:   Drug: Rivaroxaban, 10 mg;   Drug: Rivaroxaban, 7.5 mg;   Drug: Placebo
Sponsors:   Janssen Research & Development, LLC;   Bayer
Recruiting - verified April 2017

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Conditions:   Hypertension;   Cardiovascular Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting - verified January 6, 2017

Screen-and-treat Program for Chronic Kidney Disease- High Risk Persons

Condition:   Hypertension
Interventions:   Other: Screen-Educate;   Other: Screen-Educate and Intensify Treatment
Sponsor:   University of California, San Francisco
Active, not recruiting - verified April 2017

The NIH Exercise Therapy for Advanced Lung Disease Trials: Response and Adaptation to Aerobic Exercise in Patients With Interstitial Lung Disease

Conditions:   Interstitial Lung Disease;   Idiopathic Pulmonary Fibrosis;   Interstitial Pneumonitis;   Desquamative Interstitial Pneumonia
Interventions:   Other: Aerobic Exercise Training;   Other: Education
Sponsors:   National Institutes of Health Clinical Center (CC);   George Mason University;   Inova Fairfax Hospital
Recruiting - verified October 6, 2016

Glutamine Challenge as Predictor of Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt (TIPS)

Conditions:   Refractory Ascites;   Hepatic Hydrothorax;   Hepatic Encephalopathy;   Cirrhosis
Interventions:   Other: Oral glutamine challenge;   Other: Psychometric Tests
Sponsors:   University of Arkansas;   Université de Montréal;   University Hospital, Geneva
Terminated - verified April 2017

Essential Hypotension and Allostasis Registry

Conditions:   Blood Pressure;   Depression;   Panic Attack;   Fibromyalgia;   POTS;   Inappropriate Sinus Tachycardia;   Coronary Heart Disease;   Acute Coronary Syndrome (ACS);   Acute Myocardial Infarction (AMI);   Cerebrovascular Disease (CVD);   Transient Ischemic Attack (TIA);   Atrial Fibrillation;   Diabetes Mellitus;   Cancer;   Systolic Heart Failure;   Diastolic Heart Failure;   Chronic Fatigue Syndrome;   Syncope;   Vasovagal Syncope
Intervention:  
Sponsor:   CES University
Recruiting - verified April 2017

Primary Hyperaldosteronism and Ischemia-reperfusion Injury

Condition:   Primary Hyperaldosteronism
Intervention:   Procedure: forearm ischemia and reperfusion
Sponsor:   Radboud University
Enrolling by invitation - verified April 2017

Hydroxyurea in Pulmonary Arterial Hypertension

Condition:   Pulmonary Hypertension
Intervention:   Drug: Hydroxyurea
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   The Cleveland Clinic
Withdrawn - verified October 23, 2014

Evaluation of Sickle Cell Liver Disease

Condition:   Sickle Cell Disease
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified December 30, 2016

Sildenafil Therapy For Subjects Who Derive Clinical Benefit From Continued Treatment With Sildenafil

Condition:   Pulmonary Arterial Hypertension (PAH)
Intervention:   Drug: sildenafil
Sponsor:   Pfizer
Available - verified April 2017

Study Of Diabetic Nephropathy With Atrasentan

Condition:   Diabetic Nephropathy
Interventions:   Drug: Atrasentan;   Drug: Placebo
Sponsor:   AbbVie
Recruiting - verified April 2017

Resveratrol and Cardiovascular Health in the Elderly

Conditions:   Vascular Resistance;   Aging;   Hypertension;   Antioxidants;   Aerobic Capacity
Interventions:   Dietary Supplement: Resveratrol;   Drug: Placebo
Sponsor:   National Institute on Aging (NIA)
Recruiting - verified December 7, 2016

Renal Denervation in Patients With Chronic Kidney Disease

Condition:   Chronic Kidney Disease
Intervention:   Procedure: Renal Denervation
Sponsor:   Regina Qu'Appelle Health Region
Active, not recruiting - verified April 2017

A Study in Maintenance Kidney Transplant Recipients Following Conversion to Nulojix® (Belatacept)-Based

Condition:   Kidney Transplantation
Interventions:   Drug: Belatacept;   Drug: Tacrolimus;   Drug: Cyclosporine
Sponsor:   Bristol-Myers Squibb
Recruiting - verified June 2016

Treatment for Non-Alcoholic Fatty Liver With Different Doses of Vitamin E

Condition:   Fatty Liver
Interventions:   Drug: Vitamin E 200 IU/d;   Drug: Vitamin E 400 IU/d;   Drug: Vitamin E 800 IU/d;   Behavioral: Diet and Exercise
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified November 7, 2016

Adjunctive Isradipine for the Treatment of Bipolar Depression

Condition:   Bipolar Disorder
Interventions:   Drug: Isradipine;   Drug: Placebo
Sponsor:   Massachusetts General Hospital
Terminated - verified April 2017

Endothelial Function in Patients With Scleroderma or Cirrhosis With and Without Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Intervention:  
Sponsor:   The Cleveland Clinic
Recruiting - verified April 2017

Spironolactone for Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   National Institutes of Health Clinical Center (CC);   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   University of Pennsylvania;   University of Maryland;   Washington Hospital Center;   New England Medical Center, Tufts University School of Medicine
Recruiting - verified April 13, 2017

An Evaluation of the Ability to Train Established Glaucoma Patients Who Have Difficulty in Drop Instillation

Conditions:   Glaucoma;   Ocular Hypertension
Intervention:  
Sponsor:   Robin, Alan L., M.D.
Terminated - verified April 2017

MRI to Assess the Effects of Dysautonomia and Chronic Nausea on Brain Transmitters

Condition:   Dysautonomia
Intervention:  
Sponsor:   Wake Forest University Health Sciences
Active, not recruiting - verified April 2017

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2017

Mindfulness: a Novel Approach for the Management of Diabetes-related Distress

Conditions:   Emotional Distress;   Type 2 Diabetes;   Stress
Intervention:   Behavioral: Mindfulness Based Stress Reduction
Sponsor:   University of North Carolina, Chapel Hill
Completed - verified April 2017

Imatinib and Carvedilol for High Blood Pressure in the Lungs in Adults With Sickle Cell Disease

Condition:   Pulmonary Hypertension
Interventions:   Drug: Carvedilol;   Drug: Imatinib
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Withdrawn - verified December 11, 2012

Tilt Table With Suspected Postural Orthostatic Tachycardia Syndrome (POTS) Subjects

Conditions:   Postural Orthostatic Tachycardia Syndrome;   Syncope, Vasovagal;   Neurocardiogenic Syncope
Intervention:  
Sponsors:   Wake Forest University Health Sciences;   American Heart Association
Completed - verified April 2017

Global SYMPLICITY Registry

Conditions:   Hypertension;   Diabetes Mellitus;   Heart Failure;   Chronic Kidney Disease;   Sleep Apnea
Intervention:   Device: Medtronic Renal Denervation System
Sponsor:   Medtronic Vascular
Recruiting - verified April 2017

Age-Related Changes in Body Composition

Conditions:   Hypertension;   Atherosclerosis
Intervention:  
Sponsor:   National Institute on Aging (NIA)
Completed - verified October 20, 2016

Mifepristone for Metabolic Syndrome

Conditions:   Endocrine Disease;   Diabetes
Intervention:   Drug: Mifepristone
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified December 16, 2016

IMproved PREdiction of Severe Sepsis in the Emergency Department

Conditions:   Systemic Inflammatory Response Syndrome (SIRS);   Sepsis;   Severe Sepsis;   Septic Shock
Intervention:  
Sponsor:   Axis Shield Diagnostics Ltd
Completed - verified April 2017

Pulmonary Hypertension, Quality of Life and Psychosocial Factors

Condition:   Pulmonary Hypertension
Intervention:   Behavioral: Evaluation of quality of life
Sponsors:   University Hospital, Montpellier;   GlaxoSmithKline
Completed - verified April 2017

Marinobufagenin as a Target for DIGIBIND in Preeclampsia

Condition:   Preeclampsia
Intervention:  
Sponsor:   National Institute on Aging (NIA)
Completed - verified July 29, 2014

The Relationship Between Uric Acid and Inflammatory Markers

Condition:   Healthy Volunteers
Interventions:   Drug: IV Uric Acid;   Drug: IV Rasburicase
Sponsor:   National Institute on Aging (NIA)
Completed - verified January 31, 2014

Study of Nifedipine GITS and Candesartan Combination Compared to Monotherapy in Patients With Essential Hypertension

Condition:   Hypertension, Essential
Interventions:   Drug: Candesartan cilexetil (Atacand), 4 mg;   Drug: Candesartan cilexetil (Atacand), 8 mg;   Drug: Nifedipine GITS (Adalat, BAYA1040), 20 mg;   Drug: Nifedipine GITS (Adalat, BAYA1040), 30 mg;   Drug: Nifedipine GITS (Adalat, BAYA1040), 60 mg;   Drug: Placebo;   Drug: Candesartan cilexetil (Atacand), 16 mg;   Drug: Candesartan cilexetil (Atacand), 32 mg
Sponsor:   Bayer
Completed - verified April 2017

Real-time MRI Right Heart Catheterization Using Passive Catheters

Conditions:   Caridovascular Disease;   Congenital Heart Disease;   Pulmonary Hypertension
Interventions:   Device: Balloon catheter for right heart catheterization;   Drug: Gadopentate Dimeglumine (Gadolinium); Contrast Agent;   Procedure: Right Heart Catheterization;   Procedure: Cardiac Real-time MRI;   Procedure: Vascular Hemostasis
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified September 12, 2016

Fospropofol for Sedation During Elective Awake Intubation

Condition:   Impaired Airway Clearance
Interventions:   Drug: fospropofol;   Drug: fospropofol;   Drug: fospropofol;   Drug: fospropofol
Sponsors:   The Cleveland Clinic;   Eisai Inc.
Withdrawn - verified April 2017

Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome

Condition:   Adrenal Tumour With Mild Hypercortisolism
Intervention:   Procedure: Adrenalectomy
Sponsor:   Region Skane
Recruiting - verified April 2017

The Natural History of Reproductive and Overall Health in Girls and Women With a Pre-Mutation in the FMR1 Gene; Creation of a Patient Registry

Conditions:   Fragile X Syndrome;   FMR1 Premutation;   Primary Ovairan Insufficiency;   Premature Ovarian Failure;   Premature Menopause
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Terminated - verified May 31, 2013

Effect of Sodium Concentration of Priming and Rinsing Fluids on Weight Gain

Condition:   Fluid Overload and Hypertension in Hemodialysis Patients
Intervention:   Other: 5% dextrose solution
Sponsor:   Renal Research Institute
Completed - verified April 2017

Effect of Vitamin D3 on Vascular Function

Condition:   Vitamin D Deficiency
Interventions:   Drug: vitamin D;   Drug: Placebo
Sponsor:   Charles Drew University of Medicine and Science
Completed - verified February 2013

Genetics of Type 2 Diabetes in West Africans

Conditions:   Hypertension;   Diabetes
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting - verified November 15, 2016

Genetics of Type 2 Diabetes Among Han Chinese

Conditions:   Diabetes;   Obesity;   Hypertension;   Retinopathy;   Nephropathy
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Completed - verified September 14, 2016

Effects of Propranolol on Responses to Drug-Related Imagery Scripts

Condition:   Cocaine Dependence
Interventions:   Drug: Propranolol;   Drug: Placebo
Sponsor:   National Institute on Drug Abuse (NIDA)
Terminated - verified December 16, 2013

Aerobic Exercise in Patients With Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Interventions:   Procedure: Excerise Training;   Procedure: Patient Education (Placebo)
Sponsors:   National Institutes of Health Clinical Center (CC);   George Mason University;   Inova Fairfax Hospital
Completed - verified September 2, 2016

Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese Women

Conditions:   Atherosclerosis;   Diabetes Mellitus;   Obesity;   Dyslipidemia;   Hypertension
Interventions:   Behavioral: Exercise;   Behavioral: Weight Loss
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified August 18, 2015

Evaluation of Toxicity From Stem Cell Transplant

Conditions:   Organ Dysfunction;   Hemolysis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified December 7, 2015

Health Assessment Study (0954-946)

Condition:   Hypertension
Interventions:   Drug: MK0954, /Duration of Treatment : 16 Weeks;   Drug: Comparator : atenolol /Duration of Treatment : 16 Weeks
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified April 2017

Role of Nitric Oxide in Malaria

Conditions:   Malaria;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified March 30, 2015

Pulmonary Hypertension, Hypoxia and Sickle Cell Disease

Conditions:   Chuvash Polycythemia;   Cerebrovascular Disease;   Pulmonary Hypertension;   Sickle Cell Anemia
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified December 2, 2014

Magnetic Resonance Angiography to Diagnose Atherosclerotic Disease

Conditions:   Atherosclerosis;   Hyperlipidemia;   Hypertension;   Diabetes Mellitus
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed - verified May 1, 2012

Pulmonary Hypertension in Patients With Sickle Cell Disease in Nigeria

Conditions:   Secondary Pulmonary Arterial Hypertension;   Sickle Cell Disease;   Pulmonary Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified September 30, 2016

Diagnostic Performance of Screening Tests for Cushing s Syndrome

Condition:   Cushing's Syndrome
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting - verified February 8, 2016

Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension

Condition:   Pulmonary Hypertension
Interventions:   Drug: Nitric Oxide/INP Pulse Delivery;   Drug: Nitric Oxide/INO Pulse Delivery
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified December 7, 2015

Evaluation of Patients With Liver Disease

Conditions:   Biliary Liver Cirrhosis;   Hemochromatosis;   Hepatitis;   Hepatolenticular Degeneration;   Liver Disease
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 3, 2017

Establishment of a Perinatal Database and a Bank of Biological Materials

Conditions:   Preterm Labor;   Preterm Birth;   Pregnancy
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed - verified April 7, 2017

Sildenafil to Treat HIV-Associated Pulmonary Hypertension

Condition:   HIV
Interventions:   Procedure: MRI;   Drug: L-NMMA;   Drug: Acetylcholine
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Terminated - verified November 13, 2012

Biological Markers of Disease in the Prediction of Preterm Delivery, Preeclampsia and Intra-Uterine Growth Retardation: A Longtitudinal Study

Conditions:   Prenatal Care;   Premature Birth
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting - verified April 7, 2017

Effect of Clonidine on Responses to Imagery Scripts

Conditions:   Cocaine Abuse;   Heroin Abuse
Interventions:   Drug: Clonidine;   Drug: Placebo
Sponsor:   National Institute on Drug Abuse (NIDA)
Completed - verified July 8, 2014

MK0954A-264 Filter Study (0954A-264)(COMPLETED)

Condition:   Mild to Severe Hypertension
Interventions:   Drug: MK0954A, hydrochlorothiazide (+) losartan potassium / Duration of Treatment: 6 weeks;   Drug: losartan / Duration of Treatment: 6 weeks
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified April 2017

Clonidine for Relapse Prevention in Buprenorphine-Maintenance Patients

Condition:   Opioid-Related Disorders
Interventions:   Drug: Clonidine;   Drug: Placebo
Sponsor:   National Institute on Drug Abuse (NIDA)
Completed - verified September 17, 2014

Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia

Conditions:   Sickle Cell Disease;   Chronic Kidney Disease;   Pulmonary Hypertension
Intervention:   Drug: Erythropoietin and Hydroxyurea
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 27, 2016

Reference Values for Plasma Catechols

Conditions:   Healthy Volunteers;   Normal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 6, 2016

A Study in Chinese Mild to Moderate Hypertensive Patients Comparing the Efficacy of Co-Diovan With Diovan.

Condition:   Hypertension
Intervention:   Drug: valsartan plus hydrochlorothiazide
Sponsor:   Novartis
Completed - verified November 2016

Hydrochlorothiazide (+) Losartan Potassium vs. Amlodipine Comparative Study (0954A-314)

Condition:   Essential Hypertension
Intervention:   Drug: MK0954A; hydrochlorothiazide (+) losartan potassium / Duration of Treatment: 12 weeks
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified April 2017

Losartan and HCTZ and Amlodipine vs Atenolol and Amlodipine (0954A-309)(COMPLETED)

Condition:   Hypertension
Interventions:   Drug: MK0954, losartan potassium/Duration of Treatment: 18 weeks;   Drug: Comparator: losartan, HCTZ, amlodipine, atenolol/Duration of Treatment: 18 weeks
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified April 2017

Endothelial Cell Dysfunction in Pulmonary Hypertension

Condition:   Hypertension, Pulmonary
Interventions:   Procedure: Heart Catheterization;   Drug: Nitric Oxide;   Drug: Nitric Oxide/INO Pulse Delivery;   Drug: Sodium Nitrite
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed - verified December 7, 2016

BAY 43-9006 (Sorafenib) and Bevacizumab (Avastin) To Treat Solid Tumors

Condition:   Neoplasms
Interventions:   Drug: Bevacizumab;   Drug: BAY 43-9006
Sponsor:   National Cancer Institute (NCI)
Completed - verified April 23, 2014

Atorvastatin Therapy to Improve Endothelial Function in Sickle Cell Disease

Condition:   Sickle Cell Disease
Interventions:   Drug: Oxypurinol;   Drug: L-NMMA;   Drug: Acetylcholine
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed - verified December 7, 2015

Supplemental Calcium in Overweight People

Condition:   Obesity
Interventions:   Drug: Calcium supplement;   Drug: Placebo
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   Office of Dietary Supplements (ODS)
Completed - verified October 28, 2014

Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension

Conditions:   Sickle Cell Anemia;   Pulmonary Hypertension
Interventions:   Drug: Nitric Oxide;   Device: INO Pulse - NO Delivery System
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   Mallinckrodt
Completed - verified November 9, 2015

Turner Syndrome: Genotype and Phenotype

Condition:   Turner's Syndrome
Intervention:  
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Human Genome Research Institute (NHGRI)
Completed - verified July 8, 2014

Diagnosis of Pheochromocytoma

Condition:   Pheochromocytoma
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified January 6, 2017

Diabetes and Heart Disease Risk in Blacks

Conditions:   Cardiovascular;   Diabetes;   Obesity;   Hypertension
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 4, 2017

Evaluation of Patients With Heart Disease Not Eligible for Research Protocols

Condition:   Heart Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 22, 2017