Stimulants for Attention Deficit Hyperactivity Disorder

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Stimulants for Attention Deficit Hyperactivity Disorder


Generic NameBrand Name
dextroamphetamineDexedrine, Dextroamphetamine
lisdexamfetamine Vyvanse
methylphenidateConcerta, Daytrana, Metadate CD, Methylin, Ritalin
mixed salts amphetamineAdderall

How It Works

Stimulants affect how the brain controls impulses and regulates behavior and attention. They do this by influencing the availability of certain chemicals, called neurotransmitters, in the brain.

Why It Is Used

Stimulants are considered for people with moderate to severe attention deficit hyperactivity disorder (ADHD) who have difficulty in at least two different settings, such as school and home.1 Stimulant medicines with amphetamine, such as Adderall, that are used for the treatment of ADHD are approved by the U.S. Food and Drug Administration (FDA) for children age 3 and older. Stimulant medicines with methylphenidate, such as Ritalin, are approved for children age 6 and older. A doctor may prescribe methylphenidate for a child under age 6 based on the child's specific needs.

  • Methylphenidate (such as Concerta or Ritalin) is often the first choice for treating ADHD.
  • Dextroamphetamine or the combination dextroamphetamine and amphetamine (Adderall) is usually the second choice when the person does not improve with methylphenidate. But either may be the preferred medicine for older children. The long-acting form of dextroamphetamine controls behavior for a longer period of time, so fewer doses are required during the day.
  • The dextroamphetamine and amphetamine combination medicine (Adderall) is used when other stimulants have not improved symptoms or when the combination of medicines may be more helpful.

Stimulants may be used in people who have ADHD and who also have mood disorders, such as depression. The priority of which condition is treated first usually depends on which is thought to be the main disorder.

Stimulants may be used in adults when antidepressants fail to control ADHD symptoms. If antidepressants alone are not controlling symptoms, stimulants may be added.

How Well It Works

Stimulants may be the most effective treatment for the symptoms of ADHD: inattention, impulsivity, and hyperactivity. These medicines can suddenly and dramatically improve behavior. But some people need to try different types and dosages of stimulants to find the one that works best for them. If treatment with a stimulant is successful, it usually helps control symptoms over time without increasing the dosage.1

In about 70 out of 100 people who have ADHD, stimulant medicines improve symptoms.1

Children often become calmer, more organized, and less stubborn. Examples of behaviors that improve include:1

  • Less interrupting, fidgeting, and finger tapping at school; increased on-task behavior.
  • Better relationships at home with parents and siblings; better focus and on-task behavior; better compliance with parent requests and authority.
  • Improved social relationships; increased attention during sports and other activities.

Although stimulants may also improve social adjustment or academic performance for some children, they have not been shown to sustain this benefit over the long-term.

Side Effects

The most common (affecting about 50 out of 100 people) side effects of stimulants are usually related to the dose and go away after the first 2 to 3 weeks on the medicine. Persistent side effects can usually be relieved by changing the dosage level, changing when the medicine is given, or trying a different type of stimulant. The most common side effects include:

  • Decreased appetite. About 80 out of 100 people have decreased appetite. The appetite is usually least during the daytime, increasing in the evening. If the medicine is given after meals and snacks are added, especially in the evening, it may help improve the child's appetite and prevent weight loss.
  • Difficulty falling asleep.

Other side effects are also usually temporary or go away with dosage adjustment. These include:

  • Stomachache.
  • Headache.
  • Slightly increased blood pressure (in black males).

Long-term use of stimulant medicine appears to be safe and effective.2

Stimulant medicines may be related to slower growth in children, especially in the first year of taking the medicine. But most children seem to catch up in height and weight by adulthood. Your doctor will keep track your child's growth and watch for problems.2

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

Most of the medicines used to treat ADHD come with a U.S. Food and Drug Administration (FDA) warning about possible heart-related or mental problems. Before starting a medicine for ADHD, tell your doctor if your child or you have any heart problems, heart defects, or mental health problems.

Methylphenidate and dextroamphetamine usually take effect within 1 hour after the first dose. Talk to your doctor about the best time to take the medicine.

Treatment with stimulants may be continued as long as the symptoms are present, the medicine continues to work, and there are no significant side effects.

People with ADHD do not tend to abuse stimulant medicine and very rarely develop dependence on (addiction to) on the medicine. Also, there is no evidence that people with ADHD who take stimulants are at greater risk for abusing other drugs. In fact, people who take stimulants for ADHD may be less likely to abuse drugs.3

Some people buy or steal stimulant medicines. Parents need to be certain that their child takes his or her medicine and does not share it with or sell it to anyone else. If this is a concern, talk to your doctor about your child taking a medicine in a safer form.

When stimulants are used to treat ADHD and a dose is missed, do not increase doses to catch up. If several doses are missed, begin taking the medicine again on the regular schedule.

Tips for giving methylphenidate or dextroamphetamine to children:

  • It is best to start the medicine on the weekend so you can better see how the child reacts to the medicine.
  • A low dose of methylphenidate is usually given at first. The dose is increased until the child's behavior is controlled. It is important to follow the prescribed dosage schedule and watch for changes in behavior.
  • It is better to give the medicine after meals rather than before so it doesn't interfere with the child's appetite and weight gain.
  • Most children who take stimulants for ADHD function best when medicines are used continuously. But some children may function well enough to take a break from medicines on weekends and holidays. Even for these children, it is usually helpful to continue the medicine on weekends if activities are planned that require concentration and attention, such as team sports, church activities, or educational programs.

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  1. American Academy of Child and Adolescent Psychiatry (2002). Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults. Journal of the American Academy of Child and Adolescent Psychiatry, 41(2, Suppl): 26S–49S.
  2. Greenhill LL, Hechtman LI (2009). Attention-deficit/hyperactivity disorder. In BJ Sadock et al., eds., Kaplan and Sadock's Comprehensive Textbook of Psychiatry, 9th ed., vol. 2, pp. 3560–3572. Philadelphia: Lippincott Williams and Wilkins.
  3. Upadhyaya HP (2008). Substance use disorders in children and adolescents with attention-deficit/hyperactivity disorder: Implications for treatment and the role of the primary care physician. Primary Care Companion Journal of Clinical Psychiatry. 10(3): 211–221.


ByHealthwise Staff
Primary Medical ReviewerAdam Husney, MD - Family Medicine
Specialist Medical ReviewerLouis Pellegrino, MD - Developmental Pediatrics
Last RevisedFebruary 2, 2012

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