tipranavir

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tipranavir

Pronunciation:tip RA na veer
Brand:Aptivus

What is the most important information I should know about tipranavir?

Do not use this medication if you are allergic to tipranavir or ritonavir (Norvir), or if you have moderate to severe liver disease.

donotLife-threatening side effects can occur if you take tipranavir with any of the following medications: alfuzosin (Uroxatral), amiodarone (Cordarone, Pacerone), bepridil (Vascor), cisapride (Propulsid), flecainide (Tambocor), lovastatin (Mevacor, Altoprev, Advicor), sildenafil (Revatio for pulmonary arterial hypertension), simvastatin (Zocor, Simcor, Vytorin), propafenone (Rythmol), rifampin (Rifadin, Rifamate, Rimactane), quinidine (Quin-G), pimozide (Orap), midazolam (Versed), triazolam (Halcion), St. John's wort, or an ergot medicine such as Ergomar, Ergotrate, Cafergot, D.H.E. 45, Migranal, or Methergine.

There are many other medicines that can interact with tipranavir. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.

donotTipranavir is used in combination with a similar drug called ritonavir (Norvir). Some people taking this combination of medicines have developed life-threatening medical problems including liver damage and bleeding in the brain. If you are taking these two medications, call your doctor at once if you have any of the following side effects:
  • unusual bleeding (such as a nosebleed or blood in your urine or stools);
  • sudden headache, confusion, problems with vision, speech, or balance;
  • low fever, nausea, stomach pain, loss of appetite;
  • dark urine, clay-colored stools; or
  • jaundice (yellowing of the skin or eyes).

What is tipranavir?

Tipranavir is an antiviral medication in a group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Tipranavir prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

Tipranavir is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Tipranavir is not a cure for HIV or AIDS.

Tipranavir may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before taking tipranavir?

donotDo not use this medication if you are allergic to tipranavir or ritonavir (Norvir), if you have moderate to severe liver disease, or if you are using any of the following drugs:

Life-threatening side effects can occur if you take tipranavir with any of the following medications:

  • alfuzosin (Uroxatral),
  • amiodarone (Cordarone, Pacerone);
  • bepridil (Vascor);
  • cisapride (Propulsid);
  • flecainide (Tambocor);
  • lovastatin (Mevacor, Altoprev, Advicor) or simvastatin (Zocor, Simcor, Vytorin);
  • midazolam (Versed) or triazolam (Halcion);
  • pimozide (Orap);
  • propafenone (Rythmol);
  • quinidine (Quin-G);
  • rifampin (Rifadin, Rifamate, Rimactane);
  • sildenafil (Revatio for pulmonary arterial hypertension);
  • St. John's wort; or
  • ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).

If you have any of these other conditions, you may need a tipranavir dose adjustment or special tests:

  • liver disease (especially hepatitis B or C);
  • diabetes;
  • high cholesterol or triglycerides;
  • a bleeding disorder such as hemophilia; or
  • if you are allergic to sulfa drugs.
nopregFDA pregnancy category C. It is not known whether tipranavir will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.
bcpTipranavir can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking tipranavir.
nobrfeedWomen with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

How should I take tipranavir?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

If you also take ritonavir, take it at the same time you take tipranavir unless your doctor has told you otherwise.

foodTipranavir works best if you take it with food. Swallow the capsule whole. Do not break or chew it.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

To be sure this medicine is helping your condition and is not causing harmful effects, your blood will need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly.

emtIf you need surgery, tell the surgeon ahead of time that you are using tipranavir.

Use tipranavir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

Store an unopened bottle of tipranavir capsules in the refrigerator. Do not freeze. After opening the bottle for the first time, you may store the capsules at room temperature. Throw away any capsules you have not used within 60 days after you first opened the medicine bottle.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

emtSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking tipranavir?

If you also take didanosine, take it 2 hours before or after you take tipranavir.

donotTaking this medication will not prevent you from passing HIV to other people. Avoid having unprotected sex or sharing razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What are the possible side effects of tipranavir?

emtGet emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
donotSome people taking tipranavir and ritonavir have developed life-threatening medical problems including liver damage and bleeding in the brain. If you are taking these two medications, call your doctor at once if you have any of the following side effects:
  • unusual bleeding (such as a nosebleed or blood in your urine or stools);
  • sudden headache, confusion, problems with vision, speech, or balance;
  • low fever, nausea, stomach pain, loss of appetite;
  • dark urine, clay-colored stools; or
  • jaundice (yellowing of the skin or eyes).
donotStop taking tipranavir and call your doctor at once if you have any of these serious side effects:
  • severe skin rash, blistering, peeling, or sunburn;
  • increased urination or extreme thirst;
  • easy bruising or bleeding; or
  • signs of a new infection, such as fever or chills, cough, skin lesions, or flu symptoms.

Less serious side effects may include:

  • mild nausea, vomiting, diarrhea, stomach pain;
  • headache, tired feeling; or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect tipranavir?

Many drugs can interact with tipranavir. Below is just a partial list. Tell your doctor if you are using:

  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • bosentan (Tracleer);
  • colchicine (Colcrys);
  • disulfiram (Antabuse);
  • enfuvirtide (Fuseon);
  • fluticasone (Advair, Flonase, Flovent);
  • insulin or diabetes medication you take by mouth;
  • itraconazole (Sporanox) or ketoconazole (Nizoral);
  • methadone (Methadose, Diskets, Dolophine);
  • omeprazole (Prilosec);
  • rifabutin (Mycobutin);
  • salmeterol (Advair, Serevent);
  • vitamin E (especially at high doses);
  • an antidepressant such as desipramine (Norpramin), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), trazodone (Desyrel), and others;
  • heart or blood pressure medication such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nicardipine (Cardene), nisoldipine (Sular), or verapamil (Calan, Covera, Isoptin, Verelan);
  • cholesterol-lowering medicine such as atorvastatin (Lipitor) or rosuvastatin (Crestor);
  • drugs that weaken the immune system, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf);
  • medication used to prevent blood clots, such as clopidogrel (Plavix), dipyridamole (Persantine), and others;
  • medicines to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);
  • other HIV /AIDS medicine such as atazanavir (Reyataz), fosamprenavir (Lexiva), lopinavir/ritonavir (Kaletra), raltegravir (Isentress), or saquinavir (Invirase); or
  • seizure medications such as carbamazepine (Carbatrol, Tegretol), clonazepam (Klonopin), divalproex (Depakote), ethosuximide (Zarontin), lamotrigine (Lamictal), phenobarbital (Solfoton), phenytoin (Dilantin), or valproic acid (Depakene).

This list is not complete and there are many other drugs that can interact with tipranavir. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about tipranavir.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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