acetaminophen and propoxyphene

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acetaminophen and propoxyphene

Pronunciation:a SEET a MIN oh fen and proe POX i feen
Brand:Balacet, Darvocet A500, Darvocet-N 100, Darvocet-N 50, Propacet 100

Acetaminophen-Propoxyphene 500 mg-100 mg-PLI

oblong, pink, imprinted with P500

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Acetaminophen-Propoxyphene 650-100 mg Or-QUA

oblong, pink, imprinted with 5112 V

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Acetaminophen-Propoxyphene 650-100 mg Wht-QUA

oblong, white, imprinted with 5113 V

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APAP-Propoxyphene 650 mg-100 mg-TEV

oblong, pink, imprinted with 93, 890

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APAP-Propoxyphene 650-100 mg-MYL

oblong, pink, imprinted with 155, MYLAN

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APAP-Propoxyphene 650-100-TEV

oblong, white, imprinted with 93 490

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APAP-Propoxyphene 650-65 mg-MYL

oblong, orange, imprinted with 130, MYLAN

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APAP-Proproxyphene 650 mg-100 mg-Pink-MAL

oblong, pink, imprinted with 1772, M inside square

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APAP-Proproxyphene 650 mg-100 mg-White-MAL

oval, white, imprinted with 1721, M inside square

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Balacet 325 mg-100 mg-COR

oblong, lavender, imprinted with P325

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Darvocet A500

oval, orange, imprinted with A500

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Darvocet N-100

oblong, orange, imprinted with Lilly, DARVOCET-N 100

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Darvocet-N 100-XAN

oblong, orange, imprinted with DARVOCETN-N 100

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Darvocet-N 50 mg

oblong, orange, imprinted with Lilly DARVOCET N-50

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Darvocet-N 50-XAN

oblong, orange, imprinted with Darvocet-N 50

Image of Darvocet-N 50-XAN
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Propoxyphene-APAP 65-650 mg-WAT

oblong, orange, imprinted with 714 65 650, WATSON

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What is the most important information I should know about acetaminophen and propoxyphene?

Acetaminophen and propoxyphene was withdrawn from the U.S. market in November 2010.

habitPropoxyphene may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it.
donotDo not use acetaminophen and propoxyphene if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days. Serious, life threatening side effects can occur if you use acetaminophen and propoxyphene before the MAO inhibitor has cleared from your body.

What is acetaminophen and propoxyphene?

Acetaminophen and propoxyphene was withdrawn from the U.S. market in November 2010.

Propoxyphene is in a group of drugs called narcotic pain relievers.

Acetaminophen is a less potent pain reliever and a fever reducer that increases the effects of propoxyphene.

The combination of acetaminophen and propoxyphene is used to relieve mild to moderate pain with or without fever.

Acetaminophen and propoxyphene may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking acetaminophen and propoxyphene?

donotDo not use this medication if you are allergic to acetaminophen (Tylenol) or propoxyphene.
habitPropoxyphene may be habit-forming and should be used only by the person it was prescribed for. Never share this medication with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.
donotDo not use acetaminophen and propoxyphene if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

To make sure you can safely take acetaminophen and propoxyphene, tell your doctor if you have any of these other conditions:

  • asthma, COPD, sleep apnea, or other breathing disorders;
  • liver or kidney disease;
  • a history of head injury or brain tumor;
  • a gallbladder or pancreas disorder;
  • a stomach or intestinal disorder;
  • suicidal thoughts or behavior; or
  • mental illness, or a history of drug or alcohol addiction.

Tell your doctor if you drink more than three alcoholic beverages per day or if you have ever had alcoholic liver disease (cirrhosis). You may not be able to take medication that contains acetaminophen.

nopregFDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby, but it could cause breathing problems or addiction/withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
nobrfeedAcetaminophen and propoxyphene can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take acetaminophen and propoxyphene?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

donotAn overdose of acetaminophen can damage your liver. Adults should not take more than 1 gram (1000 mg) of acetaminophen per dose or 4 grams (4000 mg) per day. If you drink more than three alcoholic beverages per day, you should never use more than 2 grams (2000 mg) of acetaminophen per day.
donotDo not stop using acetaminophen and propoxyphene suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using acetaminophen and propoxyphene.
emtIf you need surgery, tell the surgeon ahead of time that you are using acetaminophen and propoxyphene. You may need to stop using the medicine for a short time.
rtStore at room temperature away from moisture and heat.
habitKeep track of the amount of medicine used from each new bottle. Propoxyphene is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?

Since acetaminophen and propoxyphene is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

emtSeek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen and propoxyphene can be fatal.

Overdose symptoms may include extreme drowsiness, nausea, vomiting, dark urine, jaundice (yellowing of the skin or eyes), pinpoint or dilated pupils, confusion, seizure (convulsions), cold and clammy skin, blue lips, weak pulse, slow or uneven heart rate, shallow breathing, fainting, or breathing that stops.

What should I avoid while taking acetaminophen and propoxyphene?

dizzyThis medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
donotAsk a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as "APAP") is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen. Check the label to see if a medicine contains acetaminophen or APAP.
noalcoholDrinking alcohol can increase certain side effects of acetaminophen and propoxyphene.

What are the possible side effects of acetaminophen and propoxyphene?

emtGet emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
donotCall your doctor at once if you have a serious side effect such as:
  • shallow breathing, slow heartbeat, feeling like you might pass out;
  • chest pain, feeling short of breath;
  • confusion, unusual thoughts or behavior;
  • seizure (convulsions); or
  • nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects include:

  • feeling dizzy or drowsy;
  • mild nausea, vomiting, upset stomach, constipation;
  • headache, blurred vision; or
  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect acetaminophen and propoxyphene?

dizzyCold or allergy medicine, sleeping pills, muscle relaxers, antidepressants, or seizure medication can add to sleepiness caused by propoxyphene, or could slow your breathing. Tell your doctor if you regularly use any of these medicines, or any other narcotic medications.

Tell your doctor about all other medications you use, especially:

  • aspirin or a blood thinner such as warfarin (Coumadin);
  • birth control pills;
  • dexamethasone (Decadron, Hexadrol);
  • a diuretic (water pill) such as furosemide (Lasix);
  • St. John's wort;
  • an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin);
  • an antidepressant such as nefazodone;
  • antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);
  • a barbiturate such as phenobarbital (Solfoton);
  • heart or blood pressure medication such as amiodarone (Cordarone, Pacerone), diltiazem (Cartia, Cardizem), nifedipine (Nifedical, Procardia), propranolol (Inderal), verapamil (Calan, Covera, Isoptin, Verelan), and others;
  • HIV or AIDS medicine such as fosamprenavir (Lexiva), nelfinavir (Viracept), ritonavir (Norvir), zidovudine (Retrovir), and others; or
  • seizure medication such as carbamazepine (Carbatrol, Tegretol), lamotrigine (Lamictal), phenytoin (Dilantin), and others.

This list is not complete and there are many other drugs that can interact with acetaminophen and propoxyphene. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about acetaminophen and propoxyphene.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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