My Plan for Starting a PCSK9 Inhibitor

If your clinician talks to you about starting a PCSK9 inhibitor, it means you could benefit from aggressively lowering your low-density lipoprotein cholesterol (LDL-C) and, in turn, lower the likelihood that you will have a heart attack or stroke.



How To Use This Tool

The American College of Cardiology created “My Plan For Starting a PCSK9 Inhibitor” to help you track changes to your LDL-C levels, know what questions to ask, and what to expect when getting started on a PCSK9 inhibitor.

Download the PDF


The tool also will help you:

  • Share your goals for treatment
  • Understand why this medication is being prescribed
  • Review how it fits with your other medications
  • Know what to expect (for example, the preapproval process, that the medication is given as an injection under your skin either once monthly or every two weeks, cost, etc.)

Why is This Medication Recommended?

  • When LDL cholesterol levels are high — and remain elevated over time — so does your risk of heart disease and stroke (also called cardiovascular disease).
  • We know people with very high LDL-C levels and those who have had a heart attack or stroke can benefit from additional LDL-C lowering.
  • PCSK9 inhibitors work by blocking a certain protein called PCSK9. This helps your liver remove and clear LDL-C from your blood.
  • PCSK9 inhibitors have been shown to effectively lower LDL-C and reduce heart-related events, including heart attacks and strokes.


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Published: April 2019