Fludarabine is available as an
oral and intravenous (IV) medicine.
Fludarabine is an antimetabolite medicine. It causes cell death
by interfering with the way genetic material (DNA) in the cell
Fludarabine is used in combination with other medicines to treat
chronic lymphocytic leukemia (CLL) and
non-Hodgkin's lymphoma (NHL).
Fludarabine is an effective treatment for chronic lymphocytic
leukemia (CLL) that has not responded to other types of chemotherapy, such as
chlorambucil or cyclophosphamide. Studies are ongoing to find out the safety
and effectiveness of fludarabine in people who have not received other types of
chemotherapy or who are responding to other types of chemotherapy.
Side effects are common with fludarabine and can include:
See Drug Reference for a full list of side effects. (Drug Reference
is not available in all systems.)
Fludarabine should be given only under the supervision of a
medical oncologist or
You may not be able to become pregnant or father a child after
taking this medicine. Discuss fertility with your doctor before starting
Fludarabine can cause birth defects. Do not use this medicine if
you are pregnant or if you wish to become pregnant or father a child while you are
Fludarabine can interact with many other medicines. Be sure that
your doctor has a complete list of all prescription and
nonprescription medicines you are taking.
Do not drink alcoholic beverages or take medicines containing
aspirin while being treated with fludarabine, because these can cause bleeding
from your stomach.
Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
March 29, 2012
Anne C. Poinier, MD - Internal Medicine & Douglas A. Stewart, MD - Medical Oncology
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