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Mar 31, 2014

Study Tests New Medication for Chronic Coronary Heart Disease

A new drug to reduce inflammation shows no added benefit in patients with stable heart disease.

Inflammation has been linked to heart disease in many large studies. Lp-PLA2, a marker of inflammation measured in the bloodstream, is blocked by a new medication called darapladib. However, according to a study presented at the American College of Cardiology’s 63rd Scientific Session, darapladib failed to show a survival benefit in patients who were already treated with optimal medications for their heart disease.

This study, known as STABILITY, enrolled 15,828 patients with stable heart disease in different countries. Half of them received the oral medication darapladib. The medication was generally well tolerated without major safety concerns during the 3.7 year follow-up period. Darapladib showed no significant benefit in reducing first heart attacks, stroke, or death from heart disease. The most common side effect of this medication was diarrhea, which led to stopping the drug among some participants.

Future studies are underway to see if patients that are suffering from heart attacks may receive additional benefits from treatment with darapladib.


Air Pollution Accelerates Damage to the Heart's Arteries

Study shows how long-term exposure to air pollution promotes dangerous calcium build-up.

Equally Aggressive Treatment Needed for Men and Women with Heart Disease

While risk factors may differ, study findings suggest plaque build-up in arteries is just as dangerous in all patients.

Heavy Drinking Increases Heart Risks in Men

Study links heavy drinking to stiffened arteries in men.

South American Tribe Has World's Healthiest Arteries, Study Finds

What we can learn from the Tsimane tribe, in which heart disease hardly exists.

New Plaque Test Helps Identify High-Risk Heart Patients

Near-infrared spectroscopy (NIRS) helps identify heart disease patients at increased risk for heart attack and stroke, finds study.