Women and Heart Disease

Clinical Trial Finder

Many women with coronary artery disease are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Long Term Follow Up for CTSN Mitral Valve Repair Studies

Conditions:   Mitral Valve Insufficiency;   Coronary Artery Disease
Interventions:   Other: MV Repair;   Other: MV Replacement;   Other: CABG
Sponsors:   Icahn School of Medicine at Mount Sinai;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research (CIHR)
Not yet recruiting - verified March 2017

Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabeTes (PROMINENT)

Conditions:   Type2 Diabetes;   Dyslipidemia
Interventions:   Drug: K-877;   Drug: Placebo
Sponsors:   Kowa Research Institute, Inc.;   Brigham and Women's Hospital
Not yet recruiting - verified March 2017

Migraine and CVD Risk in Women

Condition:   Migraine
Interventions:   Other: Mixed meal tolerance testing;   Other: Skin conductance & cold pressor test;   Other: Flow-mediated dilation testing
Sponsor:   University of Pennsylvania
Not yet recruiting - verified March 2017

Efficacy of Cardio-Oncology Rehabilitation Exercise for Women With Breast Cancer and Treatment Related Cardiotoxicity

Conditions:   Breast Cancer;   Left Ventricular Dysfunction;   Heart Failure, Systolic
Intervention:   Other: Exercise Rehabilitation
Sponsors:   University Health Network, Toronto;   MSH-UHN AMO Innovation Fund;   Canadian Institutes of Health Research (CIHR)
Not yet recruiting - verified March 2017

Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women

Conditions:   Estrogen Deficiency;   Cardiovascular Disease (CVD);   Hypothalamic Amenorrhea
Interventions:   Drug: 17beta Estradiol;   Drug: Transdermal placebo patch;   Drug: Progesterone;   Drug: Placebo Pill
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified March 2017

Study to Evaluate the Effect of Nicotinamide Riboside on Immunity

Conditions:   Atherosclerosis;   Diabetes;   Coronary Artery Disease
Interventions:   Dietary Supplement: Nicotinamide riboside (NR);   Other: Placebo
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 15, 2017

MOMENTUM 3 Continued Access Protocol

Condition:   Advanced Refractory Left Ventricular Heart Failure
Intervention:   Device: HeartMate 3 LVAS
Sponsors:   St. Jude Medical;   Thoratec, LLC
Recruiting - verified March 2017

Vascular Aging in Flight Attendants With Occupational Secondhand Smoke Exposure

Conditions:   Vascular Aging;   Secondhand Smoking
Interventions:   Procedure: Spirometry;   Procedure: Pulse Wave Analysis;   Procedure: Peripheral arterial tonometry
Sponsors:   Cedars-Sinai Medical Center;   University of California, San Francisco
Suspended - verified March 2017

WISE CVD - Continuation (WISE HFpEF)

Conditions:   Microvascular Coronary Dysfunction;   Cardiovascular Disease
Interventions:   Procedure: Coronary Angiography;   Procedure: Coronary Reactivity Testing;   Procedure: Cardiac Magnetic Resonance Imaging;   Procedure: Cardiac Magnetic Resonance Angiography;   Procedure: Computed Coronary Tomographic Angiography;   Procedure: Rest-Stress Millar Testing;   Procedure: Aortic vasorelaxation tests
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified March 2017

Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease

Condition:   Microvascular Coronary Dysfunction
Interventions:   Other: Handgrip;   Other: Altitude simulation;   Other: Leg exercise
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified March 2017

MOMENTUM 3 IDE Clinical Study Protocol

Condition:   Advanced Refractory Left Ventricular Heart Failure
Interventions:   Device: HeartMate 3 LVAS;   Device: HeartMate II LVAS
Sponsors:   Thoratec Corporation;   St. Jude Medical
Active, not recruiting - verified March 2017

Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia

Condition:   Critical Limb Ischemia
Interventions:   Procedure: Open surgical revascularization;   Device: Endovascular revascularization
Sponsors:   New England Research Institutes;   Brigham and Women's Hospital;   Massachusetts General Hospital;   Boston Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified January 2017

Effects of Oral Sildenafil on Mortality in Adults With PAH

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: sildenafil citrate;   Drug: sildenafil citrate;   Drug: sildenafil citrate
Sponsor:   Pfizer
Recruiting - verified March 2017

Benefit of Elevation of HDL-C in Women

Condition:   Cardiovascular Outcomes
Interventions:   Drug: Niaspan;   Drug: Placebo
Sponsor:   Cedars-Sinai Medical Center
Completed - verified March 2017

The "Virtual" Multicenter Spontaneous Coronary Artery Dissection (SCAD) Registry

Conditions:   Spontaneous Coronary Artery Dissection;   SCAD
Intervention:  
Sponsor:   Mayo Clinic
Recruiting - verified March 2017

Caveolin-1 and Vascular Dysfunction

Conditions:   Hypertension;   Insulin Resistance
Interventions:   Drug: Para-aminohippuric Acid;   Drug: Angiotensin II;   Drug: Norepinephrine
Sponsors:   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI);   National Institutes of Health (NIH)
Active, not recruiting - verified March 2017

Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care

Conditions:   Adenovirus;   Adrenal Insufficiency;   Airway Swelling;   Anesthesia;   Anxiety;   Anxiolysis;   Autism;   Autistic Disorder;   Bacterial Meningitis;   Bacterial Septicemia;   Benzodiazepine;   Bipolar Disorder;   Bone and Joint Infections;   Brain Swelling;   Central Nervous System Infections;   Convulsions;   Cytomegalovirus Retinitis;   Early-onset Schizophrenia Spectrum Disorders;   Edema;   Epilepsy;   General Anesthesia;   Gynecologic Infections;   Headaches;   Herpes Simplex Virus;   Hypertension;   Infantile Hemangioma;   Infection;   Inflammation;   Inflammatory Conditions;   Influenza;   Intra-abdominal Infections;   Lower Respiratory Tract Infections;   Migraines;   Pain;   Pneumonia;   Prophylaxis;   Schizophrenia;   Sedation;   Seizures;   Skeletal Muscle Spasms;   Skin and Skin-structure Infections;   Stable Angina;   Thromboprophylaxis;   Thrombosis;   Treatment-resistant Schizophrenia;   Urinary Tract Infection;   Withdrawal
Intervention:   Drug: The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
Sponsors:   Daniel Benjamin;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   The EMMES Corporation;   OpAns, LLC
Recruiting - verified March 2017

SYMPLICITY HTN-3 Renal Denervation in Patients With Uncontrolled Hypertension

Condition:   Uncontrolled Hypertension
Interventions:   Device: Renal denervation (Symplicity Catheter System);   Diagnostic Test: Renal angiogram
Sponsor:   Medtronic Vascular
Completed - verified March 2017

Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction

Condition:   Cardiovascular Disease
Intervention:   Procedure: Cardiac MRI
Sponsors:   Cedars-Sinai Medical Center;   National Heart, Lung, and Blood Institute (NHLBI);   University of Florida;   University of Pittsburgh
Active, not recruiting - verified March 2017

Heart Disease of the Small Arteries in Women and Men

Condition:   Heart Disease
Intervention:   Procedure: noninvasive tests
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified March 2017

The Effects of Traditional Acupuncture on Mechanisms of Coronary Heart Disease

Condition:   Coronary Artery Disease
Interventions:   Procedure: Traditional Acupuncture;   Procedure: AA
Sponsors:   Cedars-Sinai Medical Center;   National Center for Complementary and Integrative Health (NCCIH)
Completed - verified March 2017

Cardiac Magnetic Resonance Imaging (MRI) Normal Reference Control Group Testing

Condition:   Healthy
Intervention:   Other: Cardiac MRI
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified March 2017

Estrogen Deficiency and Cardiovascular Disease in Premenopausal Women

Condition:   Estrogen Deficiency
Interventions:   Procedure: Blood test;   Genetic: Blood test;   Procedure: Ultrasound of neck arteries;   Procedure: Saliva test
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified March 2017

Reproductive Hormones And Pre-Clinical Cardiovascular Disease (CVD) In Women

Condition:   Heart Disease
Intervention:  
Sponsors:   Cedars-Sinai Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified March 2017

Cardiac Stem Cell Infusion in Patients With Ischemic CardiOmyopathy (SCIPIO)

Conditions:   Coronary Artery Disease;   Congestive Heart Failure
Intervention:   Biological: Treatment group
Sponsors:   University of Louisville;   Brigham and Women's Hospital;   Jewish Hospital and St. Mary's Healthcare
Completed - verified March 2017