Diabetes (Type 2 Diabetes)

Clinical Trial Finder

Many patients with type 2 diabetes are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Diabetes Pueblo Program - Application and Acceptability of Culturally Appropriate Latino Education for Insulin Therapy

Condition:   Type2 Diabetes
Intervention:   Behavioral: Diabetes Pueblo
Sponsors:   Sansum Diabetes Research Institute;   Eli Lilly and Company
Recruiting

C-peptide Concentrations in Type 2 Diabetes Treated With Insulin; is it Time to Revise the Treatment of Type 2 Diabetes

Condition:   Type 2 Diabetes Treated With Insulin
Intervention:   Diagnostic Test: C-peptide concentrations
Sponsor:   Goztepe Training and Research Hospital
Completed

Type 2 Diabetes and Alteration of Immune System of Intestinal Mucosa : Proof of Concept

Condition:   Type 2 Diabetes
Intervention:   Other: Biopsy
Sponsor:   University Hospital, Toulouse
Recruiting

Does Dapagliflozin Regress Left Ventricular Hypertrophy In Patients With Type 2 Diabetes?

Conditions:   Type 2 Diabetes;   Left Ventricular Hypertrophy
Interventions:   Drug: Dapagliflozin;   Drug: Placebo
Sponsors:   University of Dundee;   NHS Tayside;   AstraZeneca
Completed

Impact of Long Alimentary Limb or Long Biliary Limb Roux-en-Y Gastric Bypass on Type 2 Diabetes Remission in Severely Obese Patients.

Condition:   Diabetes Mellitus Type 2 in Obese
Interventions:   Procedure: Standard Roux-en-Y gastric bypass;   Procedure: Long alimentary limb Roux-en-Y gastric bypass
Sponsors:   University Hospital, Lille;   Ministry of Health, France
Not yet recruiting

Effect of Bariatric Surgery on Mechanisms of Type 2 Diabetes

Conditions:   Obesity;   Type 2 Diabetes
Interventions:   Procedure: laparoscopic roux en y gastric bypass operation;   Other: medical management
Sponsor:   The Cleveland Clinic
Completed

Effects of Liraglutide on the Cognitive Function in Patients With Type 2 Diabetes Mellitus

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Liraglutide;   Drug: placebo
Sponsor:   Third Military Medical University
Completed

Effect of Dihydromirycetin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes Mellitus

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Dihydromyricetin;   Drug: Metformin
Sponsor:   University of Guadalajara
Not yet recruiting

Diabetes Dietary Study- Low Carbohydrate and Low-Fat Diets in Type 2 Diabetes

Condition:   Type 2 Diabetes
Interventions:   Behavioral: low-carbohydrate diet;   Behavioral: low-fat diet
Sponsors:   Albert Einstein College of Medicine;   Robert C. Atkins Foundation
Completed

Alcohol Consumption and Type 2 Diabetes Mellitus Risk in Nonalcoholic Fatty Liver Disease

Conditions:   Nonalcoholic Fatty Liver Disease;   Light-to-moderate Alcohol Consumption;   Type2 Diabetes Mellitus
Intervention:  
Sponsor:   Ningbo No. 1 Hospital
Completed

Kidney Biopsy Indications in Type 2 Diabetes Patients

Condition:   Type 2 Diabetes, Chronic Kidney Disease
Intervention:  
Sponsor:   Rennes University Hospital
Recruiting

Safety and Efficacy Study of Exenatide Once Weekly in Adolescents With Type 2 Diabetes

Condition:   Children and Adolescent With Type 2 Diabetes
Interventions:   Drug: Exenatide Once Weekly;   Drug: Placebo
Sponsor:   AstraZeneca
Active, not recruiting

Effects of Combining Cocoa and Soy in Type 2 Diabetes

Conditions:   Type 2 Diabetes;   Dietary Intervention
Interventions:   Dietary Supplement: Soy protein;   Dietary Supplement: Isoflavones;   Dietary Supplement: Cocoa;   Dietary Supplement: Placebo
Sponsors:   Hull and East Yorkshire Hospitals NHS Trust;   University of Hull
Completed

Taking Action: a Care for Type 2 Diabetes Intervention for Couples

Condition:   Type 2 Diabetes
Interventions:   Behavioral: Communal Coping Intervention;   Behavioral: Diabetes Education
Sponsor:   Carnegie Mellon University
Not yet recruiting

Cardiac Rest and Stress Metabolism in Patients With Type 2 Diabetes

Conditions:   Diabetes Mellitus, Type 2;   Metabolic Cardiomyopathy;   Metabolic Disturbance;   Fatty Acid Oxidation Disorder
Intervention:   Other: Surely observational based on disease state
Sponsor:   University of Leicester
Recruiting

Remission of Type 2 Diabetes With Dapagliflozin (READ Trial)

Condition:   Type 2 Diabetes
Interventions:   Behavioral: Intensive lifestyle intervention;   Drug: Dapagliflozin 10 MG;   Drug: Placebo oral tablet
Sponsor:   Shanghai Zhongshan Hospital
Not yet recruiting

A Study of Tirzepatide (LY3298176) Compared to Dulaglutide in Participants With Type 2 Diabetes

Condition:   Type 2 Diabetes
Interventions:   Drug: Tirzepatide;   Drug: Dulaglutide
Sponsor:   Eli Lilly and Company
Recruiting

A Study of LY3209590 in Participants With Type 2 Diabetes Mellitus

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: LY3209590;   Drug: Insulin Degludec
Sponsor:   Eli Lilly and Company
Recruiting

Effects of SGLT2 Inhibitors on Islet Cell Function and Insulin Sensitivity in Patients of Type 2 Diabetes Mellitus

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Dapagliflozin;   Drug: Empagliflozin;   Drug: Canagliflozin
Sponsor:   Peking Union Medical College Hospital
Not yet recruiting

A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes

Condition:   Type 2 Diabetes
Interventions:   Drug: Tirzepatide;   Drug: Semaglutide
Sponsor:   Eli Lilly and Company
Not yet recruiting

A Study of LY900014 Compared to Insulin Lispro (Humalog) in Adults With Type 2 Diabetes

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: LY900014;   Drug: Insulin Lispro;   Drug: Insulin Glargine;   Drug: Insulin Degludec
Sponsor:   Eli Lilly and Company
Recruiting

Effects and Safety of OPK-88003 Dose Escalation in Type 2 Diabetes Subjects

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: OPK-88003;   Drug: Placebo
Sponsors:   OPKO Ireland Global Holdings Ltd.;   OPKO Health, Inc.
Completed

A Study of Tirzepatide (LY3298176) Versus Insulin Degludec in Participants With Type 2 Diabetes

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Tirzepatide;   Drug: Insulin Degludec
Sponsor:   Eli Lilly and Company
Recruiting

A Study of Dulaglutide (LY2189265) in Children and Adolescents With Type 2 Diabetes

Condition:   Type 2 Diabetes
Interventions:   Drug: Dulaglutide;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Recruiting

A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Not Controlled With Diet and Exercise Alone

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Tirzepatide;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Recruiting

A Study of Basal Insulin Analog and Insulin Analog Mid Mixture in Chinese Participants With Type 2 Diabetes Mellitus

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Insulin Analog Mid Mixture;   Drug: Basal Insulin Analog
Sponsor:   Eli Lilly and Company
Active, not recruiting

A Study of Tirzepatide (LY3298176) Once a Week Versus Insulin Glargine Once a Day in Participants With Type 2 Diabetes and Increased Cardiovascular Risk

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Tirzepatide;   Drug: Insulin Glargine
Sponsor:   Eli Lilly and Company
Recruiting

A Study to Investigate the Effect of MEDI0382 on Hepatic Glycogen Metabolism in Overweight and Obese Subjects With Type 2 Diabetes Mellitus.

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: MEDI0382;   Drug: Placebo;   Drug: Liraglutide
Sponsor:   MedImmune LLC
Recruiting

Multi-center, Single Arm, Observational Study to Evaluate the Safety of Dapagliflozin in Type 2 Diabetes Mellitus Patients in China

Condition:   Type 2 Diabetes Mellitus
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Comparison of Insulin Tregopil (IN-105) With Insulin Aspart in Type 2 Diabetes Mellitus Patients

Condition:   Type2 Diabetes Mellitus
Interventions:   Drug: Insulin Tregopil;   Drug: Insulin Aspart
Sponsor:   Biocon Limited
Completed

Study to Evaluate the Efficacy and Safety of DWP16001 in Patients With Type 2 Diabetes Mellitus

Condition:   T2DM (Type 2 Diabetes Mellitus)
Interventions:   Drug: DWP16001;   Drug: Placebo
Sponsor:   Daewoong Pharmaceutical Co. LTD.
Not yet recruiting

Partners for Better Health in Adolescent Type 2 Diabetes: The Buddy Study

Conditions:   Obesity;   Diabetes Mellitus, Type 2;   Abnormal Glucose Metabolism;   Type 2 Diabetes
Intervention:   Behavioral: Assignment of a Lay Patient Partner
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

A Study of People With Type 2 Diabetes Who Have Diseases That Affect the Heart and Blood Vessels. The Study Will Also Look at the Treatment of a Group of These People in Hospitals in Portugal

Condition:   Diabetes Mellitus, Type 2
Intervention:   Other: No treatment given
Sponsor:   Novo Nordisk A/S
Enrolling by invitation

Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus Not Currently Treated With Antidiabetic Therapy

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: Placebo
Sponsor:   Sanofi
Completed

Efficacy and Safety of Evoglitin in Patients With Type 2 Diabetes and Non-alcoholic Fatty Liver Diseases

Conditions:   Type2 Diabetes;   Non-Alcoholic Fatty Liver Disease
Interventions:   Drug: Evogliptin;   Drug: Pioglitazone
Sponsor:   Dong-A ST Co., Ltd.
Enrolling by invitation

Statin Compliance of Patients With Non-insulin-dependent Diabetes

Condition:   Non-insulin-dependent Diabetes
Intervention:   Other: Girerd test
Sponsors:   Lille Catholic University;   University Hospital, Lille
Terminated

The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes

Conditions:   Type 2 Diabetes Mellitus;   Obesity
Interventions:   Procedure: Roux-en-Y Gastric Bypass Surgery;   Procedure: Laparoscopic Adjustable Gastric Banding;   Behavioral: Lifestyle Weight Loss Intervention
Sponsors:   University of Pittsburgh;   National Institutes of Health (NIH);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting

ABO-GLYC in Type 2 Diabetes

Condition:   Type2 Diabetes
Interventions:   Device: ABO-GLYC;   Other: ABO-GLYC Placebo
Sponsors:   Aboca Spa Societa' Agricola;   Latis S.r.l.;   Fondazione Edmund Mach
Recruiting

Comparing High and Normal Protein Diets for the Dietary Remission of Type 2 Diabetes

Conditions:   Diabetes Type 2;   Obesity;   Diet Modification
Interventions:   Behavioral: High Protein Diet;   Behavioral: Standard Protein Diet
Sponsor:   University of Alabama at Birmingham
Recruiting

Impact of Changes in Muscle Secretome in the Remission of Type 2 Diabetes Mellitus Induced by Bariatric Surgery

Condition:   Diabete Type 2
Intervention:   Diagnostic Test: Muscle biopsy and blood test
Sponsor:   Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Recruiting

Effectiveness and Cost-effectiveness of a Telemonitoring Program for Diabetic People at Home

Condition:   Type 2 Diabetes
Interventions:   Other: telemonitoring;   Other: Usual care
Sponsor:   University Hospital, Toulouse
Completed

A Long-term Study on the Side Effects of TRADIANCE in Japanese Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: TRADIANCE® Combination Tablets AP;   Drug: TRADIANCE® Combination Tablets BP
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting

Lanifibranor in Patients With Type 2 Diabetes & Nonalcoholic Fatty Liver Disease

Conditions:   Nonalcoholic Fatty Liver Disease (NAFLD);   Type 2 Diabetes (T2DM)
Interventions:   Drug: Lanifibranor;   Other: Placebo
Sponsors:   University of Florida;   Inventiva Pharma
Recruiting

Biweekly Interval Intermittent Fasting for Type 2 Diabetes, a Safety Study

Conditions:   Diabetes Type 2;   Pre-diabetes
Intervention:   Other: Intermittent Fasting
Sponsor:   Seth Leavitt
Not yet recruiting

Effect of Dapagliflozin on Inflammation and Endothelial Function

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Dapagliflozin;   Drug: Placebo
Sponsor:   Baylor College of Medicine
Terminated

An International Survey of the Occurrence of Cardiovascular Disease Among Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Intervention:   Other: No treatment given
Sponsor:   Novo Nordisk A/S
Enrolling by invitation

Effects of Caloric Restriction in Obesity and Type 2 Diabetes

Conditions:   Type 2 Diabetes;   Obesity
Interventions:   Behavioral: Calorie restriction (25%);   Behavioral: Ad libitum health diet
Sponsors:   Mario Negri Institute for Pharmacological Research;   Istituto Superiore di Sanità
Active, not recruiting

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Transcutaneous Electrical Nerve Stimulator to Improve Blood Glucose Control in Patients With Type 2 Diabetes Mellitus

Condition:   Type 2 Diabetes Mellitus
Interventions:   Device: Transcutaneous Electrical Nerve Stimulator (DW1330);   Device: Sham DW1330 device
Sponsor:   Taiwan Resonant Waves Research Corporation
Recruiting

The Impact of Liraglutide on Glucose Tolerance and the Risk of Type 2 Diabetes in Women With Previous Pregnancy-induced Diabetes

Condition:   Gestational Diabetes Mellitus
Interventions:   Drug: Liraglutide;   Drug: Placebo
Sponsors:   Tina Vilsboll;   Novo Nordisk A/S;   Rigshospitalet, Denmark;   Hvidovre University Hospital;   Herlev Hospital;   Hillerod Hospital, Denmark;   University of Copenhagen;   The Novo Nordisk Foundation Center for Basic Metabolic Research;   Aarhus University Hospital
Active, not recruiting

Growth Hormone Feedback to Insulin-like Growth Factor-I (IGF-1) and Oral Glucose Tolerance Test (OGTT)

Conditions:   Acromegaly;   Type 2 Diabetes Mellitus
Interventions:   Diagnostic Test: Oral Glucose Tolerance Test;   Diagnostic Test: Subcutaneous administration of recombinant human IGF-1;   Diagnostic Test: Placebo
Sponsor:   Cedars-Sinai Medical Center
Completed

Real World Assessment of Clinical Outcome Changes -Including Month of Ramadan-for Dapagliflozin in Management of Type II Diabetes Mellitus

Condition:   Type II Diabetes Mellitus
Intervention:  
Sponsor:   AstraZeneca
Completed

Value-based Emotion-focused Educational Programme to Reduce Diabetes-related Distress

Condition:   Type 2 Diabetes Mellitus
Interventions:   Behavioral: VEMOFIT;   Behavioral: Attention-meetings (AG)
Sponsors:   Universiti Putra Malaysia;   Ministry of Health, Malaysia;   UMC Utrecht
Completed

Risk of Bladder Cancer in Type 2 Diabetes Patients With Pioglitazone Therapy "PROBE"

Condition:   Bladder Cancer
Intervention:   Drug: Pioglitazone
Sponsor:   Postgraduate Institute of Medical Education and Research
Recruiting

Secular Trends in the Prevalence of Diabetes in India

Conditions:   Type2 Diabetes;   PreDiabetes
Intervention:  
Sponsor:   India Diabetes Research Foundation & Dr. A. Ramachandran's Diabetes Hospitals
Completed

The Effect of Topical Doxycycline Gel on HbA1c in Patients With Type 2 Diabetes Mellitus(DM) ®

Condition:   Diabetes Mellitus With Periodontal Disease
Interventions:   Drug: Doxycycline Group;   Drug: placebo topical gel
Sponsor:   Amirhossein Farahmand
Completed

Effect of Short-Term Beta-Cell Rest in Adolescents and Young Adults With Type 2 Diabetes Mellitus

Conditions:   Obesity;   Overweight;   Diabetes Mellitus, Type 2
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Simplification of Complex Insulin Regimens With Preserving Good Glycemic Control in Type 2 Diabetes

Conditions:   HBA1c;   Body Weight;   Hypoglycemia
Intervention:   Other: de-escalation of complex insulin regimens
Sponsors:   Bekes County Central Hospital;   University of Debrecen;   Szeged University
Recruiting

Genetics of Type 2 Diabetes in West Africans

Conditions:   Hypertension;   Diabetes
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

Effect of Propolis or Metformin Administration on Glycemic Control in Patients With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Propolis;   Drug: Metformin;   Drug: Placebo
Sponsor:   University of Guadalajara
Not yet recruiting

Fenofibrate in Type 2 Diabetes

Condition:   Diabetes Mellitus, Type II
Intervention:   Drug: Fenofibrate
Sponsor:   Medical University of South Carolina
Recruiting

Malaysia Diabetes Ramadan Nutrition Plan (My Dia-RNP®): A Feasibility Study

Condition:   Type 2 Diabetes Mellitus
Interventions:   Other: Nutrition Intervention based on My Dia-RNP;   Other: Usual Care
Sponsors:   Universiti Putra Malaysia;   Nestle Health Science;   Joslin Diabetes Center
Recruiting

Adaptation of a Digital Weight Loss Intervention Promoting Self-regulation for Use in Type 2 Diabetes

Conditions:   Diabetes Mellitus, Type 2;   Overweight and Obesity
Intervention:   Behavioral: Behavioral weight loss with digital tools
Sponsor:   University of North Carolina, Chapel Hill
Not yet recruiting

Decreasing Stress in Type 2 Diabetes

Conditions:   Stress;   Diabetes Mellitus, Type 2
Interventions:   Behavioral: Mindfulness Based Stress Reduction;   Behavioral: Stress Management Education
Sponsors:   Milton S. Hershey Medical Center;   Rowan University;   Penn State University;   National Institutes of Health (NIH);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting

Extension to Study 200952 to Evaluate the Long-term Safety, Tolerability and Pharmacodynamics of Albiglutide Liquid Drug Product in Type 2 Diabetes Mellitus Subjects

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Albiglutide;   Device: Auto-injector
Sponsor:   GlaxoSmithKline
Terminated

A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

A Study to Observe the Effectiveness of Empagliflozin, Other SGLT-2 Inhibitors, or DPP-4 Inhibitors in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Subjects treated with Empagliflozin or any Sodium-glucose cotransporter-2 (SGLT-2) inhibitor;   Drug: Subjects treated with Dipeptidyl peptidase-4 (DPP-4) inhibitor
Sponsor:   Boehringer Ingelheim
Active, not recruiting

A Study of LY3305677 in Participants With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: LY3305677;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Not yet recruiting

A Research Study, Looking at How Tresiba® Works in People With Type 2 Diabetes in Local Clinical Practice in Saudi Arabia

Condition:   Diabetes Mellitus, Type 2
Intervention:   Drug: Insulin degludec
Sponsor:   Novo Nordisk A/S
Enrolling by invitation

A Study of Tirzepatide in Participants With Type 2 Diabetes Mellitus (T2DM)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Tirzepatide;   Drug: Semaglutide;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Not yet recruiting

Long Term Daily Use of JARDIANCE® Tablets in Japanese Patients With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Intervention:   Drug: Jardiance
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting

A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo
Sponsor:   Novo Nordisk A/S
Recruiting

BDPP Treatment for Mild Cognitive Impairment (MCI) and Prediabetes or Type 2 Diabetes Mellitus (T2DM)

Conditions:   Mild Cognitive Impairment;   Alzheimer's Disease
Intervention:   Drug: grape seed polyphenolic extract, resveratrol
Sponsors:   Johns Hopkins University;   Icahn School of Medicine at Mount Sinai
Recruiting

Efficacy and Safety of Oral Semaglutide Versus Empagliflozin in Subjects With Type 2 Diabetes Mellitus

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: empagliflozin
Sponsor:   Novo Nordisk A/S
Completed

A Study of LY3209590 in Japanese Participants With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: LY3209590;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Active, not recruiting

Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes and Moderate Renal Impairment

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Completed

A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

Safety of Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors Among Patients With Type 2 Diabetes

Conditions:   Diabetes Mellitus, Type 2;   Urosepsis;   Diabetic Ketoacidosis;   Lower Extremity Amputation
Interventions:   Drug: Sodium-glucose cotransporter 2 (SGLT2) inhibitors;   Drug: Dipeptidyl peptidase-4 (DPP-4) inhibitors;   Drug: Other treatment combinations
Sponsors:   Canadian Network for Observational Drug Effect Studies, CNODES;   Drug Safety and Effectiveness Network, Canada;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting

Safety and Efficacy of Oral Semaglutide Versus Dulaglutide Both in Combination With One OAD (Oral Antidiabetic Drug) in Japanese Subjects With Type 2 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Dulaglutide
Sponsor:   Novo Nordisk A/S
Completed

A Research Study Comparing a New Medicine Oral Semaglutide to Sitagliptin in People With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Oral semaglutide;   Drug: Sitagliptin;   Drug: Placebo (oral semaglutide);   Drug: Placebo (sitagliptin)
Sponsor:   Novo Nordisk A/S
Not yet recruiting

An International Survey of the Occurrence of Diseases That Affects the Heart and Blood Vessels Among People With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Intervention:   Other: No treatment given
Sponsor:   Novo Nordisk A/S
Completed

Effect of Continuous vs Intermittent Aerobic Exercise on Glycemic Control in a Barbadian Population With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Behavioral: Single Bout ('S');   Behavioral: Multiple Bout ('M')
Sponsor:   Springfield College
Not yet recruiting

Efficacy and Safety of Oral Semaglutide Using a Flexible Dose Adjustment Based on Clinical Evaluation Versus Sitagliptin in Subjects With Type 2 Diabetes Mellitus.

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: sitagliptin
Sponsor:   Novo Nordisk A/S
Completed

A Trial Comparing Insulin Degludec/Liraglutide, Insulin Degludec, and Liraglutide in Chinese Subjects With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs (OADs)

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: Insulin degludec/liraglutide;   Drug: Insulin degludec;   Drug: Liraglutide
Sponsor:   Novo Nordisk A/S
Active, not recruiting

Effects of 5 Weeks Treatment With Dapagliflozin in Type 2 Diabetes Patients on How the Hormone Insulin Acts on Sugar Uptake in Muscles.

Conditions:   Diabetes Mellitus, Type 2;   Skeletal Muscle Insulin Sensitivity
Intervention:   Drug: Dapagliflozin
Sponsor:   AstraZeneca
Recruiting

A Research Study in People With Type 2 Diabetes to Compare Two Types of Insulin: Insulin 287 and Insulin Glargine

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Insulin 287;   Drug: Insulin glargine U100
Sponsor:   Novo Nordisk A/S
Recruiting

A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Events

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: insulin degludec;   Drug: insulin glargine
Sponsor:   Novo Nordisk A/S
Completed

A Research Study to Compare Insulin 287 Once a Week to Insulin Glargine (100 Units/mL) Once a Day in People With Type 2 Diabetes.

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Insulin 287;   Drug: Placebo (insulin 287);   Drug: Metformin;   Drug: Dipeptidyl peptidase-4 inhibitors;   Drug: Insulin glargine;   Drug: Placebo (insulin glargine)
Sponsor:   Novo Nordisk A/S
Active, not recruiting

A Research Study to Compare Two Types of Insulin: Insulin 287 and Insulin Glargine in People With Type 2 Diabetes Who Have Not Used Insulin Before

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Insulin 287;   Drug: Insulin Glargine
Sponsor:   Novo Nordisk A/S
Recruiting

Efficacy in Controlling Glycaemia With Victoza® (Liraglutide) as add-on to Metformin vs. OADs as add-on to Metformin After up to 104 Weeks of Treatment in Subjects With Type 2 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: liraglutide;   Drug: alpha-glucosidase inhibitors;   Drug: DPP-4 inhibitors;   Drug: meglitinides;   Drug: SGLT-2 inhibitors;   Drug: sulphonylurea;   Drug: thiazolidinediones
Sponsor:   Novo Nordisk A/S
Active, not recruiting

A Research Study to Compare Semaglutide to Insulin Aspart, When Taken Together With Metformin and Insulin Glargine, in People With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Insulin aspart;   Drug: Insulin glargine U100
Sponsor:   Novo Nordisk A/S
Recruiting

DISCOVER Global Registry

Condition:   Type 2 Diabetes
Intervention:  
Sponsor:   AstraZeneca
Recruiting

A Research Study to Compare Two Doses of Semaglutide Taken Once Weekly in People With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors

Conditions:   Cardiovascular Disease;   High Cardiovascular Risk;   Obesity;   Overweight;   Type 2 Diabetes
Interventions:   Drug: Lorcaserin hydrochloride;   Drug: Placebo
Sponsors:   Eisai Inc.;   Thrombolysis In Myocardial Infarction (TIMI) Academic Research Organization
Completed

Effect of Exenatide LAR or Dulaglutide on the Variability of 24-hour Heart Rate and Blood Pressure in Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Exenatide LAR;   Drug: Dulaglutide
Sponsor:   University of Guadalajara
Recruiting

Cardiovascular Inflammation Reduction Trial

Condition:   Cardiovascular Disease
Interventions:   Drug: Methotrexate;   Drug: Placebo
Sponsors:   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

An Observational Study of Alogliptin Benzoate in Participants With Diabetes Mellitus Type 2

Condition:   Diabetes Mellitus
Intervention:   Drug: Alogliptin Benzoate
Sponsor:   Takeda
Completed

Continuous Glucose Monitors to Regulate Glucose Levels in Type 2 Diabetics - (Protocol 3)

Condition:   Type2 Diabetes
Interventions:   Device: Continuous Glucose Monitor (CGM);   Device: Activity Tracker;   Behavioral: Coaching
Sponsor:   Savvysherpa, Inc.
Active, not recruiting

A Phase IV Study in Drug-Naive Patients With T2DM in China

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Dapagliflozin;   Drug: Acarbose
Sponsor:   AstraZeneca
Recruiting

Clinical Characteristics and Practice Patterns of Type 2 Diabetes Mellitus Patients Treated With OADs in Japan: Analysis of Medical and Health Care Database of the MDV

Condition:   Diabetes Mellitus, Type 2
Intervention:   Drug: oral antidiabetic drugs
Sponsor:   Boehringer Ingelheim
Completed

Efficacy and Safety of Insulin Rinsulin® NPH Compared to Humulin® NPH in Type 2 Diabetes Mellitus Patients

Condition:   Diabetes Mellitus, Type 2
Interventions:   Biological: Insulin Humulin® NPH;   Biological: Insulin Rinsulin® NPH
Sponsor:   Geropharm
Completed

An Artificial Intelligence Assisted Telehealth Intervention to Promote Self-Management in Patients With Type 2 Diabetes Mellitus (Qualitative Interview)

Condition:   Diabetes Mellitus
Intervention:   Behavioral: Semi-structured Interview
Sponsor:   University of Alabama at Birmingham
Recruiting

Patient and Caregiver-Centered Diabetes Telemanagement Program for Hispanic/Latino Patients

Conditions:   Type 2 Diabetes Mellitus;   Type2 Diabetes
Interventions:   Other: Comprehensive Outpatient Management;   Behavioral: Diabetes Telemonitoring
Sponsors:   Northwell Health;   Patient-Centered Outcomes Research Institute
Not yet recruiting

A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in United Kingdom, as Part of Local Clinical Practice (SURE UK)

Condition:   Diabetes Mellitus, Type 2
Intervention:   Drug: Semaglutide
Sponsor:   Novo Nordisk A/S
Enrolling by invitation

A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in The Netherlands, as Part of Local Clinical Practice (SURE NETHERLANDS)

Condition:   Diabetes Mellitus, Type 2
Intervention:   Drug: semaglutide
Sponsor:   Novo Nordisk A/S
Enrolling by invitation

Comparative Effectiveness of Empagliflozin in the US

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Empagliflozin;   Drug: DPP-4 inhibitor
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting

A Study to Evaluate the Efficacy and Safety of MEDI0382 in the Treatment of Overweight and Obese Subjects With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: MEDI0382 low dose;   Drug: MEDI0382 mid dose;   Drug: MEDI0382 high dose;   Drug: Placebo;   Drug: Liraglutide
Sponsors:   AstraZeneca;   MedImmune LLC
Completed

Diabetes, Exercise and Liver Fat (DELIVER)

Conditions:   Type 2 Diabetes Mellitus;   Non-Alcoholic Fatty Liver Disease;   Obesity;   Insulin Resistance;   Liver Diseases;   Fatty Liver;   Diabetes Mellitus;   Glucose Metabolism Disorders;   Glucose Intolerance;   Metabolic Disease
Intervention:   Behavioral: Exercise
Sponsors:   James King;   University Hospitals, Leicester;   Nottingham University Hospitals NHS Trust;   University of Nottingham
Recruiting

Lifestyle Intervention IN Gestational Diabetes (LIVING)

Condition:   Gestational Diabetes Mellitus in Pregnancy
Intervention:   Behavioral: Life style Intervention
Sponsors:   The George Institute;   National Health and Medical Research Council, Australia;   All India Institute of Medical Sciences, New Delhi
Recruiting

A Double-blind Study to Investigate Efficacy, Safety and Tolerability of BAY1142524 in Patients With Type II Diabetes and a Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Fulacimstat (BAY1142524);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Denmark and Sweden, as Part of Local Clinical Practice (SURE DENMARK/SWEDEN)

Condition:   Diabetes Mellitus, Type 2
Intervention:   Drug: Semaglutide
Sponsor:   Novo Nordisk A/S
Active, not recruiting

Specific Clinical Experience Investigation for Long-term Use of Bydureon.

Condition:   Type 2 Diabetes
Intervention:  
Sponsor:   AstraZeneca
Active, not recruiting

Empa PASS on Urinary Tract Malignancies

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: empagliflozin;   Drug: DPP-4 inhibitors
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting

Influence of Preprandial Metformin Administration on Carbohydrate Absorption

Conditions:   Impaired Glucose Tolerance;   Type2 Diabetes
Intervention:   Other: Oral glucose tolerance test (OGTT) with or without metformin
Sponsor:   University Hospital, Lille
Not yet recruiting

A 12 Month Site Randomized Trial in Adults With Type 2 Diabetes Mellitus and History of Cardiovascular Disease

Conditions:   Diabetes Mellitus, Type 2;   Cardiovascular Diseases
Intervention:   Other: Intense Education Intervention
Sponsors:   Duke University;   Boehringer Ingelheim;   Eli Lilly and Company
Not yet recruiting

Investigating the Use of Quercetin on Glucose Absorption in Obesity, and Obesity With Type 2 Diabetes

Conditions:   Obesity;   Diabetes
Interventions:   Other: Quercetin;   Other: Placebo
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Comparison of Gastric By-Pass and Optimized Medical Treatment in Obese Diabetic Patients

Conditions:   Obesity;   Diabetes
Interventions:   Procedure: Gastric By-Pass;   Drug: optimized medical management
Sponsor:   University Hospital, Lille
Recruiting

Study of Sulphonylurea Synergy With Incretins

Condition:   Type 2 Diabetes Mellitus
Intervention:   Drug: Gliclazide
Sponsors:   University of Dundee;   NHS Tayside
Active, not recruiting

SGLT2 Inhibition in Combination With Diuretics in Heart Failure

Conditions:   Heart Failure;   Type 2 Diabetes Mellitus
Interventions:   Drug: Empagliflozin 25mg;   Drug: Placebo oral capsule
Sponsors:   University of Dundee;   British Heart Foundation
Completed

Specific Clinical Experience Investigation for Long-term Use of Exenatide (Byetta Subcutaneous Injection)

Condition:   Type 2 Diabetes
Intervention:  
Sponsor:   AstraZeneca
Active, not recruiting

Transporters for Organic Cations and Glycemic Control in Patients With Neuropathic Pain.

Conditions:   Neuropathic Pain;   Type 2 Diabetes Mellitus;   Diabetic Neuropathy, Painful
Interventions:   Procedure: Serial Blood Samples;   Procedure: Serial Urine Samples;   Drug: Gabapentin 300 mg;   Drug: Cetirizine Hydrochloride 10 mg
Sponsors:   Natalia Valadares de Moraes;   University of Sao Paulo
Completed

Diabetes Study of Linagliptin and Empagliflozin in Children and Adolescents (DINAMO)TM

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Linagliptin;   Drug: Empagliflozin;   Drug: Placebo
Sponsor:   Boehringer Ingelheim
Recruiting

The Role of Traditional or Western Diet in the TBC1D4 Gene on Glucose Homeostasis in Greenland Inuits

Condition:   T2D
Intervention:   Other: Cross-over study
Sponsors:   University of Copenhagen;   Steno Diabetes Center Copenhagen;   Novo Nordisk A/S
Recruiting

Effect of RVX000222 on Time to Major Adverse Cardiovascular Events in High-Risk T2DM Subjects With CAD

Conditions:   Diabetes Mellitus, Type 2;   Coronary Artery Disease;   Cardiovascular Diseases
Interventions:   Drug: RVX000222;   Drug: Placebo (for RVX000222);   Drug: atorvastatin;   Drug: rosuvastatin
Sponsors:   Resverlogix Corp;   PPD;   ICON plc;   Medidata Solutions
Active, not recruiting

Effect of a Very Low-Calorie Ketogenic Diet on Gut Microbiota and Fat Distribution

Condition:   Obesity
Intervention:   Dietary Supplement: Whey protein, vegetable protein or animal protein
Sponsor:   University of Roma La Sapienza
Recruiting

Effective Enhancement of Glucose Tolerance and Prevention of Diabetes Mellitus Type 2 by Polyherbal Formulation

Conditions:   Diabetes Mellitus;   Pre Diabetes
Intervention:   Dietary Supplement: Polyherbal formulation
Sponsor:   Islamia University of Bahawalpur
Completed

A Cohort Study of Weight Loss and Gliosis

Condition:   Obesity, Gliosis, Weight-Loss
Interventions:   Behavioral: Behavioral Weight Loss Program;   Procedure: Roux-en-Y Gastric Bypass
Sponsor:   University of Washington
Recruiting

Insulin Detemir in Obesity Management

Conditions:   Diabetes;   Obesity
Intervention:   Drug: Detemir
Sponsors:   Vanderbilt University;   Novo Nordisk A/S
Active, not recruiting

Empaglifozin in Early Diabetic Kidney Disease

Conditions:   Diabetic Kidney Disease;   Diabetes Mellitus Type 2
Interventions:   Drug: Empagliflozin;   Other: Placebo
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting

Observational, Data Collection Study for Subjects With Diabetes Using Daily Insulin Injections and Monitoring Glucose by Continuous Glucose Monitoring or Self-Monitoring Blood Glucose

Condition:   Subjects With Diabetes Using Daily Insulin Injections and Monitoring Glucose by Continuous Glucose Monitoring or Self-Monitoring Blood Glucose
Interventions:   Drug: Multiple Daily Injections of Insulin;   Drug: Single insulin injections
Sponsor:   DreaMed Diabetes
Not yet recruiting

Genetics of Obesity, Diabetes, and Heart Disease in African Diaspora Populations

Conditions:   Diabetes;   Cardiovascular Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Enrolling by invitation

A Study Comparing the Injection Site Pain Experience After the Injection of 2 Different Solutions of Semaglutide With 2 Different Injection Pens, a Compound for the Treatment of Type 2 Diabetes and Obesity

Conditions:   Healthy Volunteers Diabetes Mellitus, Type 2;   Healthy Volunteers Overweight;   Healthy Volunteers Obesity
Interventions:   Drug: Semaglutide (administered by DV3396 pen);   Drug: Semaglutide (administered by PDS290 pen)
Sponsor:   Novo Nordisk A/S
Recruiting

Effect of Linagliptin + Metformin vs Metformin Alone in Patients With Prediabetes

Conditions:   Prediabetic State;   Insulin Resistance
Interventions:   Combination Product: Linagliptin + metformin;   Drug: Metformin
Sponsors:   Universidad de Guanajuato;   Hospital Regional de Alta Especialidad del Bajio
Completed

Genetics of Insulin and Incretins in Cystic Fibrosis

Condition:   Cystic Fibrosis
Interventions:   Genetic: Blood or Saliva Sample Collection;   Other: Glucose -potentiated arginine (GPA) stimulation tests
Sponsors:   Children's Hospital of Philadelphia;   University of Pennsylvania
Recruiting

Epigenetics Based Diagnosis of Diabetes in Saliva and Blood Samples

Conditions:   Prediabetic State;   Diabetes Mellitus, Type 2;   Ectopic Lipids;   Epigenetics Based Modifications
Interventions:   Diagnostic Test: Blood sampling;   Diagnostic Test: Saliva and blood samples;   Diagnostic Test: Magnet Resonance Spectroscopy
Sponsor:   Medical University of Vienna
Recruiting

"Hyaluronan" Formulation for Type 2 Diabetic Patients With Dry Mouth

Conditions:   Dry Mouth;   Xerostomia;   Type 2 Diabetics
Interventions:   Device: HA formulation Oral Spray;   Device: Placebo
Sponsor:   You First Services
Recruiting

Toe-brachial Index and Coronary Calcification in Type 1 and 2 Diabetes

Condition:   Coronary Artery Calcification
Intervention:   Other: Data collection
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting

The CArdiovasCulAr Diabetes & Ethanol (CASCADE) Trial

Conditions:   Diabetes;   Prediabetes
Intervention:   Dietary Supplement: alcohol
Sponsor:   Ben-Gurion University of the Negev
Completed

Peer Support To Enhance The Shanghai Integration Model Of Diabetes Care: Dissemination To 12 Communities

Conditions:   Type2 Diabetes;   PreDiabetes
Intervention:   Behavioral: Peer Support Integrated with Primary Care
Sponsors:   Shanghai 6th People's Hospital;   University of North Carolina, Chapel Hill;   Merck Foundation
Recruiting

Antidiuretic Function Before and During Treatment With SGLT2 Inhibitors (GliRACo 1)

Conditions:   Diabetes Mellitus, Type 2;   Arterial Hypertension;   Body Weight Changes
Intervention:   Drug: SGLT2 inhibitor
Sponsor:   University of Turin, Italy
Recruiting

Feasibility Study of New Subcutaneous Glucose Sensor With Recording Devices - Phase 3 Group

Conditions:   Type 1 Diabetes;   Type 2 Diabetes
Intervention:   Device: Guardian Sensor (3)
Sponsor:   Medtronic Diabetes
Not yet recruiting

Smart and Secure Children Program for Preschool Obesity

Conditions:   Obesity;   Type 2 Diabetes
Interventions:   Behavioral: SSC Program;   Behavioral: Written Handouts
Sponsors:   Baylor College of Medicine;   Texas Children's Hospital;   University of Houston
Active, not recruiting

Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes

Condition:   Diabetes Type 2
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Safety, Tolerability and Efficacy of LMB763 in Patients With Diabetic Nephropathy

Condition:   Diabetic Nephropathy
Interventions:   Drug: LMB763;   Other: Placebo
Sponsor:   Novartis Pharmaceuticals
Recruiting

Mood and Insulin Resistance in Adolescents At-Risk for Diabetes

Conditions:   Depression;   Impaired Glucose Tolerance
Interventions:   Other: The Blues Program;   Other: Hey Durham
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   National Institutes of Health Clinical Center (CC)
Completed

A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome

Condition:   Cushing Syndrome
Interventions:   Drug: Relacorilant;   Other: Placebo
Sponsor:   Corcept Therapeutics
Recruiting

DANHEART (H-HeFT and Met-HeFT)

Conditions:   Heart Failure;   Diabetes
Interventions:   Drug: Hydralazine Isosorbide Dinitrate;   Drug: Placebo Oral Tablet;   Drug: Metformin Hydrochloride
Sponsors:   Henrik Wiggers;   Danish Heart Foundation;   Danish Council for Independent Research;   The Danish Regions: Foundation for Medical Research;   The Novo Nordisk Foundation;   The Aase og Ejnar Danielsen Foundation
Recruiting

REmodelling in Diabetic CardiOmapathy: Gender Response to PDE5i InhibiTOrs

Conditions:   Diabetic Cardiomyopathy;   Diabetes Mellitus Type 2
Interventions:   Drug: Tadalafil;   Drug: Placebo
Sponsor:   University of Roma La Sapienza
Completed

A Behavioral Intervention to Prevent Gestational Diabetes Mellitus

Condition:   Diabetes, Gestational
Intervention:   Behavioral: Lifestyle intervention with APP
Sponsor:   Peking University Third Hospital
Not yet recruiting

Comprehensive Lifestyle Modification for Patients With Hypertension and Metabolic Syndrome: a Multicenter Randomized Controlled Trial

Conditions:   Hypertension;   Metabolic Syndrome
Interventions:   Behavioral: Comprehensive Lifestyle Modification;   Behavioral: Standard Lifestyle Modification / modified DASH
Sponsors:   Universität Duisburg-Essen;   Kliniken Essen-Mitte;   Immanuel Hospital Berlin, Berlin, Germany;   Charite University, Berlin, Germany;   University of Witten/Herdecke
Completed

Canagliflozin-Mealtime Insulin Rescue

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: canagliflozin;   Drug: placebo
Sponsors:   Atlanta Research and Education Foundation;   Janssen Scientific Affairs, LLC
Active, not recruiting

NEPHSTROM for Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Biological: Mesenchymal Stromal Cells;   Other: Placebo
Sponsors:   Mario Negri Institute for Pharmacological Research;   Leiden University Medical Center;   ASST Papa Giovanni XXIII, Bergamo, Italy;   IRCCS - Istituto di Ricerche Farmacologiche Mario Negri - Bergamo, Italy;   Belfast Health and Social Care Trust;   National University of Ireland, Galway, Ireland;   University Hospital Birmingham, NHS Foundation Trust, Hospital, Birmingham, UK;   NHS Blood and Transplant
Recruiting

Meal-time Administration of Exenatide for Glycaemic Control in Type 1 Diabetic Cases

Condition:   Diabetes Mellitus, Type 1
Interventions:   Drug: Exenatide;   Drug: Placebos
Sponsors:   Filip Krag Knop;   Steno Diabetes Center Copenhagen
Completed

Optimization of Glycemic Control in the Hospital and Critical Care Setting

Conditions:   Hyperglycemia;   Diabetes Mellitus
Intervention:   Device: iPro Continuous Glucose Monitoring
Sponsor:   Ohio State University
Active, not recruiting

Glucagon-like Peptide-1 Metabolism and Acute Neprilysin Inhibition

Conditions:   Diabetes Mellitus, Type 2;   Pre-diabetic;   Hypertension;   Elevated Blood Pressure
Interventions:   Drug: Sacubitril/Valsartan 200mg (blinded);   Drug: Valsartan 160mg (blinded)
Sponsor:   University of Pennsylvania
Suspended

Effect of Dapagliflozin/Metformin XR vs Monotherapies on Anthropometric Indicators in Obesity

Condition:   Obesity
Interventions:   Drug: Dapagliflozin;   Drug: Dapagliflozin plus Metformin XR;   Drug: Metformin XR
Sponsor:   University of Guadalajara
Recruiting

LIRA-ADD2SGLT2i - Liraglutide Versus Placebo as add-on to SGLT2 Inhibitors.

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: liraglutide;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Completed

A French Study to Evaluate the Usefulness of Implantable Continuous Glucose Monitoring (CGM) Sensor to Improve Glycemic Control in Participants With Diabetes Mellitus.

Condition:   Diabetes Mellitus
Interventions:   Device: Eversense XL;   Device: Usual SMBG or FGM device used by participants
Sponsors:   Hoffmann-La Roche;   Roche Diabetes Care France SAS
Recruiting

Comparative User Experiences With BD Nano™ PRO 4mm x 32G Extra Thin Wall Pen Needle vs Three Commercially Available Pen Needles

Condition:   Diabetes
Interventions:   Device: BD Nano™ PRO;   Device: 33G Artsana Insupen Extr3me;   Device: 34G Artsana Insupen Extr3me;   Device: Simple Diagnostics Comfort EZ™
Sponsor:   Becton, Dickinson and Company
Completed

In-market Utilisation of Liraglutide Used for Weight Management in Europe

Conditions:   Metabolism and Nutrition Disorder;   Obesity
Intervention:   Drug: liraglutide
Sponsor:   Novo Nordisk A/S
Completed

Dapagliflozin on Blood Pressure Variability and Ambulatory Arterial Stiffness Index in Hypertension

Condition:   Hypertension
Interventions:   Drug: Dapagliflozin;   Drug: Placebo - Cap
Sponsor:   University of Guadalajara
Enrolling by invitation

Multi-component Intervention for Diabetes in Adults With Serious Mental Illness

Conditions:   Schizophrenia;   Obesity;   Diabetes;   Lifestyle Risk Reduction;   Serious Mental Illness
Intervention:   Behavioral: Multi-component Intervention for Diabetes in Adults with Serious Mental Illness
Sponsor:   University of California, San Diego
Recruiting

Association of Cystatin C and Bone Mineral Density in Diabetic Patients.

Conditions:   Osteoporosis;   Osteoporosis, Postmenopausal;   Diabetes Mellitus
Intervention:   Radiation: Dual-energy X-ray absorptiometry
Sponsor:   Fifth Affiliated Hospital, Sun Yat-Sen University
Recruiting

High-intensity Interval Training and Mixed Meal Responses in Persons With Spinal Cord Injury

Condition:   Paraplegia
Intervention:   Other: Exercise
Sponsor:   University of Bath
Recruiting

Metabolic Effects of the SGLT-2 Inhibitor Empagliflozin in Patients With Diabetic Nephropathy (MEDiaN)

Condition:   Diabetic Nephropathies
Intervention:   Drug: Empagliflozin 10 MG
Sponsors:   Singapore General Hospital;   Duke-NUS Graduate Medical School
Recruiting

Primary Care eHealth Intervention for Improved Outcomes in Chronic Kidney Disease

Conditions:   Renal Insufficiency, Chronic;   Kidney Failure, Chronic
Intervention:   Other: eHealth Intervention
Sponsors:   University of California, San Francisco;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

The SongDance Study: Stress, Ongoing Self- Monitoring and Diabetes, Nerve Stimulation and Cognitive Empowerment

Condition:   Diabetes Mellitus, Type 2, Stress
Intervention:   Device: active stress handling
Sponsor:   Herlev Hospital
Active, not recruiting

Effect of Dapagliflozin on Blood Pressure Variability in Prediabetes and Prehypertension

Conditions:   PreDiabetes;   Prehypertension
Interventions:   Drug: Dapagliflozin;   Drug: Placebo - Cap
Sponsor:   University of Guadalajara
Active, not recruiting

Effect of Preoperative Oral Carbohydrates on the Glycemic Variability of Diabetic Patients

Condition:   Diabetes
Intervention:   Dietary Supplement: carbohydrate group
Sponsor:   Yonsei University
Recruiting

NASH and Coronary Disease

Condition:   Non-Alcoholic Fatty Liver Disease
Intervention:   Diagnostic Test: Hepatic evaluation
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Institute of Cardiometabolism and Nutrition, France
Recruiting

A Behavioral Intervention to Prevent Impaired Glucose Tolerance Diabetes Mellitus (DIGITAL-I)

Condition:   Diabetes
Intervention:   Behavioral: Lifestyle intervention with APP
Sponsor:   Peking University Third Hospital
Not yet recruiting

Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese Women

Conditions:   Diabetes;   Obesity;   Healthy Volunteers
Interventions:   Drug: Alpha Toropherol (Vitamin E);   Dietary Supplement: Vitamin C
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Testing the Influence of Different Sugary Drink Warning Label Designs

Conditions:   Obesity;   Weight Gain;   Diabetes Type 2
Intervention:   Behavioral: Sugary drink warning labels
Sponsors:   University of Pennsylvania;   Drexel University;   New York University;   University of Connecticut;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting

Effect of Empagliflozin Versus Placebo on Brain Insulin Sensitivity in Patients With Prediabetes

Conditions:   PreDiabetes;   Body Weight
Interventions:   Drug: Empagliflozin 25mg;   Drug: Placebo Oral Tablet
Sponsor:   University Hospital Tuebingen
Recruiting

ZIMBA: Clinical Trial in Paediatric Obesity

Conditions:   Obesity, Childhood;   Insulin Resistance;   Zinc Deficiency;   Inositol
Interventions:   Dietary Supplement: Zinc;   Drug: Placebos;   Drug: Myoinositol
Sponsor:   Azienda Ospedaliero Universitaria Maggiore della Carita
Recruiting

Motivation Psychology-based Smart Engagement System

Condition:   Diabetes
Intervention:   Behavioral: MOSES
Sponsors:   Baltimore Research & Education Foundation, Inc.;   University of Maryland
Active, not recruiting

Trial to Understand Efficacy of Colesevelam in Diarrhea Predominant IBS Patients With Bile Acid Malabsorption

Conditions:   Chronic Diarrhea;   Irritable Bowel Syndrome With Diarrhea;   Bile Acid Malabsorption
Interventions:   Drug: Colesevelam;   Other: Placebo
Sponsor:   Mayo Clinic
Completed

Safety Evaluation and Effect of Food Supplement Containing Dietary Fiber From Cassava on the Alterations of Physiological Parameters in Overweight Female Volunteers

Condition:   Overweight
Intervention:   Dietary Supplement: Cassava dietary fiber capsule
Sponsor:   Khon Kaen University
Active, not recruiting

Ilaris (Canakinumab) in the Schnitzler Syndrome

Condition:   Schnitzler Syndrome
Intervention:   Drug: Ilaris
Sponsor:   Universitaire Ziekenhuizen Leuven
Completed

Screening for Genetic Forms of Diabetes in Convention of Care for Children and Adolescents With Diabetes (GENEPEDIAB)

Conditions:   Diabetes Mellitus;   MODY
Intervention:   Genetic: Mody test
Sponsor:   Université Catholique de Louvain
Recruiting

Dexcom G6 Intervention Study

Condition:   Diabetes Mellitus
Interventions:   Device: Dexcom G6 CGM - Continues Glucose Monitoring sensor system;   Diagnostic Test: POC BG - Point-of-Care Blood Glucose monitoring
Sponsor:   Emory University
Recruiting

Relative Desirability of Metformin vs. Birth Control Pill in Treating PCOS in Women of Later Reproductive Age

Condition:   Polycystic Ovary Syndrome
Interventions:   Drug: Metformin;   Drug: Oral combined hormonal contraceptives
Sponsor:   University of Virginia
Not yet recruiting

Longitudinal Study of Dental Implant Therapy in HIV- Positive Patients

Condition:   Peri-Implantitis
Intervention:  
Sponsors:   University of Alabama at Birmingham;   Dentsply Sirona Implants
Active, not recruiting

Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer

Conditions:   Breast Cancer;   Breast Tumors;   Cancer of Breast
Interventions:   Drug: Metformin;   Drug: Atorvastatin;   Procedure: Breast surgery
Sponsor:   Columbia University
Recruiting

Novel Single Wave Assessment in Measuring Cardiac Dysfunction and Metabolic Syndrome in Patients With Cancer

Condition:   Malignant Neoplasm
Interventions:   Procedure: Diagnostic Imaging;   Other: Laboratory Biomarker Analysis
Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI)
Recruiting

Studying Infant Nutrition and Blood Sugar

Conditions:   Insulin Resistance;   Obesity
Intervention:  
Sponsors:   University of Rochester;   National Institutes of Health (NIH);   The Gerber Foundation
Recruiting

Acute Study of Anthocyanin-rich Bilberry and Polyphenol-rich Apple Extracts on Postprandial Glycaemic Response

Conditions:   Glucose Intolerance;   Glucose Metabolism Disorders
Intervention:   Dietary Supplement: Fruit bar with addition of polyphenols
Sponsor:   University of Aberdeen
Recruiting

CharacterIzation of Adult Onset Autoimmune Diabetes

Condition:   Diabetes
Interventions:   Other: Mixed Meal Test;   Other: Dual Energy X-Ray Absorptiometry (DEXA);   Procedure: Adipose Tissue Biopsy
Sponsor:   Translational Research Institute for Metabolism and Diabetes, Florida
Recruiting

Clinical Application of Stem Cell Educator Therapy in Alopecia Areata

Conditions:   Alopecia Areata;   Alopecia Totalis;   Alopecia Universalis
Intervention:   Combination Product: Stem Cell Educator therapy combined with minoxidil
Sponsors:   Tianhe Stem Cell Biotechnologies Inc.;   Yale University;   Hackensack Meridian Health
Not yet recruiting

Obstructive Sleep Apnoea in Patients With Type 1 Diabetes

Conditions:   Type 1 Diabetes;   Obstructive Sleep Apnoea
Intervention:  
Sponsors:   University of Birmingham;   Heart of England NHS Trust
Recruiting

The Effects of BAY1193397 on Skin Capillary Blood Flow and Transcutaneous Oxygen Pressure

Condition:   Diabetic Foot
Interventions:   Drug: BAY1193397;   Drug: Placebo
Sponsor:   Bayer
Recruiting

Study to Evaluate the Efficacy and Safety of Belviq XR® in Conjunction With Lifestyle Modification for Weight Loss in Obese Adolescents, Age 12 to 17 Years

Condition:   Obesity
Interventions:   Drug: lorcaserin hydrochloride XR;   Drug: Placebo
Sponsor:   Eisai Inc.
Recruiting

Comparison of Probiotics, Metformin & Their Combination Therapy in the Treatment of PCOS

Condition:   Polycystic Ovary Syndrome
Interventions:   Drug: Probiotic Agent;   Drug: Metformin
Sponsor:   Ziauddin University
Recruiting

Effect of FISH Intake on MEtabolic Health in a Diabetic South Asian popuLation (FISH MEAL)

Condition:   Diabetes Mellitus, Type 2
Intervention:   Other: Tinned mackerel fish
Sponsor:   University of Aberdeen
Recruiting

Effect of LIK066 on Reduction of Fatty Content in Livers of Obese Patients

Condition:   Obese Patients With Non-alcoholic Steatohepatitis (NASH)
Interventions:   Drug: LIK066;   Drug: Placebo
Sponsor:   Novartis Pharmaceuticals
Recruiting

Characterization of Diabetes Mellitus in Fibrous Dysplasia/McCune-Albright Syndrome

Conditions:   McCune-Albright Syndrome;   Fibrous Dysplasia;   Intraductal Papillary Mucinous Neoplasm;   Diabetes Mellitus
Interventions:   Procedure: Hyperinsulinemic Euglycemic Clamp and 2H20;   Procedure: Hyperglycemic Clamp;   Diagnostic Test: Oral Glucose Tolerance Test
Sponsor:   Yale University
Active, not recruiting

Multicenter ESG Trial (MERIT Trial)

Conditions:   Obesity;   Hypertension;   Diabetes Mellitus, Type 2
Intervention:   Device: Overstitch
Sponsors:   Mayo Clinic;   University of Texas;   Johns Hopkins University;   Brigham and Women's Hospital;   NorthShore University HealthSystem;   University of Chicago;   Orlando Health, Inc.
Active, not recruiting

Preoperative Hypnosis in Gynecology

Condition:   Pelvic Gynecological Cancer
Intervention:   Behavioral: Caregiver Accompaniment Time (CAT) + preoperative hypnosis session
Sponsor:   University Hospital, Bordeaux
Completed

STEP 6: Research Study Investigating How Well Semaglutide Works in People Living With Overweight or Obesity

Conditions:   Overweight;   Obesity
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Active, not recruiting

Automated Structured Education Based on an App and AI in Chinese Patients With Type 1 Diabetes

Condition:   Type 1 Diabetes
Intervention:   Behavioral: Automated structured education intervention based on an app and artificial intelligence
Sponsor:   Second Xiangya Hospital of Central South University
Not yet recruiting