Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Stroke Ready: A Stroke Preparedness Brief Intervention

Condition:   Stroke
Interventions:   Behavioral: Stroke preparedness intervention;   Behavioral: Healthy lifestyle stroke risk reduction intervention
Sponsor:   University of Michigan
Completed

A Study of the Relationship of Gut Microbial Composition and Stroke Outcome

Condition:   Ischemic Stroke
Intervention:   Other: Stool Samples
Sponsors:   University of Virginia;   University of Colorado, Denver
Recruiting

Essential Acute Stroke Care in Low Resource Settings: a Pilot studY

Condition:   Acute Stroke
Intervention:   Other: Acute stroke care Intervention arm
Sponsors:   The George Institute;   World Heart Federation
Not yet recruiting

Limits of Stability in Sitting in Healthy Controls and Participants Post Stroke

Conditions:   Stroke;   Balance; Distorted
Intervention:   Other: In-patient stroke rehabilitation.
Sponsors:   KU Leuven;   Universitaire Ziekenhuizen Leuven
Completed

A Potential Wearable for Post-stroke Rehabilitation

Condition:   Chronic Stroke
Intervention:   Device: A functional electrical stimulation device for post-stroke rehabilitation
Sponsors:   Chinese University of Hong Kong;   The Hong Kong Polytechnic University;   City University of Hong Kong;   Shanghai Jiao Tong University School of Medicine
Not yet recruiting

The Effectiveness of Early Mobilization for Acute Ischemic Stroke Treated With Rt-PA or IA Thrombectomy

Condition:   Acute Ischemic Stroke
Interventions:   Behavioral: standard early rehabilitation;   Behavioral: adding early out-of-bed mobilization
Sponsor:   National Taiwan University Hospital
Recruiting

Determinants of Balance Recovery After Stroke - Retrospective Study

Condition:   Stroke
Intervention:   Behavioral: Postural Assessment Scale for Stroke (PASS)
Sponsor:   University Hospital, Grenoble
Completed

Factors Influencing Postural Balance and Movement in Individuals With Stroke

Conditions:   Stroke;   Movement, Abnormal;   Postural, Balance
Intervention:   Other: no intervention
Sponsor:   Vimonwan Hiengkaew
Not yet recruiting

Transitions of Care Stroke Disparity Study (TCSD-S)

Condition:   Stroke
Intervention:  
Sponsors:   University of Miami;   National Institute on Minority Health and Health Disparities (NIMHD)
Recruiting

THALES - Acute STroke or Transient IscHaemic Attack Treated With TicAgreLor and ASA for PrEvention of Stroke and Death

Conditions:   Acute Ischaemic Stroke;   Transient Ischaemic Attack
Interventions:   Drug: Ticagrelor;   Drug: Placebo
Sponsor:   AstraZeneca
Active, not recruiting

The Effect of Education Based on the Chronic Care Model (StrokeCARE) in Patients With Ischemic Stroke

Conditions:   Stroke, Ischemic;   Self Efficacy
Intervention:   Behavioral: The effect of education and telephone follow ups based on the Chronic Care Model on self-management, quality of life and patient satisfaction in patients with ischemic stroke
Sponsor:   Akdeniz University
Completed

Extracranial Carotid & Intracranial Arterial Stenosis in Ischemic Stroke

Conditions:   Ischemic Stroke;   Carotid Stenosis
Interventions:   Other: Carotid duplex+/- MRA neck;   Other: brain MRA+/-CT angio on carotid and brain;   Other: MRI brain;   Other: DSA (digital subtraction angiography)
Sponsor:   Mansoura University Hospital
Recruiting

Motor rECovery witH eArly imagiNg In STroke

Condition:   Stroke
Intervention:  
Sponsors:   Northwestern University;   National Institute of Neurological Disorders and Stroke (NINDS);   Shirley Ryan AbilityLab
Not yet recruiting

Moderate Dose Hydroxyurea for Secondary Stroke Prevention in Children With Sickle Cell Disease in Sub-Saharan Africa

Conditions:   Sickle Cell Disease;   Sickle Cell Anemia;   Stroke
Interventions:   Drug: Moderate Dose Hydroxyurea;   Drug: Low Dose Hydroxyurea
Sponsors:   Vanderbilt University Medical Center;   Aminu Kano Teaching Hospital;   Murtala Muhammed Specialist Hospital
Active, not recruiting

The TESLA Trial: Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke

Condition:   Ischemic Stroke
Intervention:   Procedure: Intra-arterial Therapy
Sponsor:   Mercy Health Ohio
Recruiting

Stroke Imaging Package Study of Intracranial Atherosclerosis ( SIPS-ICAS )

Conditions:   Acute Ischemic Stroke AIS;   Intracranial Atherosclerosis ICAS
Intervention:   Drug: aggressive medical management
Sponsors:   Wei-Hai Xu;   Peking Union Medical College Hospital;   General Hospital of Chinese Armed Police Forces;   General Hospital of Shenyang Military Region;   Subei People's Hospital of Jiangsu Province;   Fujian Medical University Union Hospital;   Tangshan Gongren Hospital;   Third Affiliated Hospital, Sun Yat-Sen University;   Qingdao Municipal Hospital;   West China Hospital;   Shanghai Tong Ren Hospital;   Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine;   The First Affiliated Hospital of University of South China;   JiNing NO.1 People Hospital;   Tongji Hospital;   The University of HongKong-Shenzhen Hospital;   Beijing Anzhen Hospital;   Beijing Hospital;   Peking University International Hospital;   Beijing Tongren Hospital;   China-Japan Friendship Hospital;   Peking University First Hospital;   Beijing Friendship Hospital;   Beijing Chao Yang Hospital;   Qilu Hospital of Shandong University (Qingdao);   Shandong Provincial Hospital;   The Second Hospital of Hebei Medical University;   Hebei General Hospital;   First Affiliated Hospital of Zhejiang University;   China-Japan Union Hospital, Jilin University;   Zhejiang Provincial Tongde Hospital;   People's Hospital of Ningxia Hui Autonomous Region;   Taiyuan Central Hospital of Shanxi Medical University;   Hong Xinglong Central Hospital;   Changzhi People's Hospital
Recruiting

Effect of Allium Cepa in the Management of Shoulder Pain Post Stroke

Condition:   Stroke
Interventions:   Biological: Topical App. of Allium Cepa Extract;   Biological: Phonophoresis of Allium Cepa Extract;   Biological: Raw Mashed Allium Cepa Application;   Other: Standard Physiotherapy Group (SPG)
Sponsors:   Bayero University Kano, Nigeria;   Physiotherapy Associates
Completed

Statistical Parametric Mapping (SPM 1D) for Stroke and Trans-tibial Amputation

Conditions:   Stroke;   Amputation
Intervention:   Diagnostic Test: 3D Gait Analysis with Statistical Parametric Mapping
Sponsors:   Tan Tock Seng Hospital;   Nanyang Technological University
Recruiting

National Retrospective Study Of Recanalization Treatments In Pediatric Arterial Ischemic Stroke

Condition:   Arterial Ischemic Stroke
Intervention:  
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting

LOTUS: Global Acute Stroke Study Utilizing Penumbra System

Condition:   Stroke, Ischemic
Intervention:   Device: Penumbra System
Sponsor:   Penumbra Inc.
Not yet recruiting

Perturbation Training for Fall-risk Reduction Among Stroke Survivors

Condition:   Stroke
Intervention:   Other: Overground slip perturbation training
Sponsors:   University of Illinois at Chicago;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Clopidogrel Preventive Effect Based on CYP2C19 Genotype in Ischemic Stroke

Condition:   Acute Ischemic Stroke
Intervention:   Drug: General principles of care and judgement of researcher
Sponsors:   Gangnam Severance Hospital;   SAMJIN PHARM
Recruiting

A Prospective Cohort Study of Perioperative Covert Stroke and Postoperative Cognitive Dysfunction

Conditions:   Anesthesia;   Postoperative Cognitive Dysfunction;   Covert Stroke
Intervention:  
Sponsor:   Beijing Tiantan Hospital
Recruiting

Left Atrial Appendage Occlusion Versus Novel Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Stroke
Interventions:   Device: Left atrial appendage occlusion;   Drug: NOAC
Sponsors:   University of Aarhus;   Aarhus University Hospital;   Aalborg University Hospital;   Odense University Hospital;   Sahlgrenska University Hospital, Sweden;   Karolinska University Hospital;   Turku University Hospital;   Haukeland University Hospital;   Helsinki University Central Hospital
Recruiting

GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

Conditions:   Stroke;   PFO - Patent Foramen Ovale
Intervention:   Device: PFO closure with GORE® CARDIOFORM Septal Occluder
Sponsor:   W.L.Gore & Associates
Recruiting

The Effect of Art Therapy on Patients With Stroke

Condition:   Ischemic Stroke and Hemorrhagic Stroke
Intervention:   Other: Art therapy
Sponsor:   Cairo University
Recruiting

IpsiHand System for Rehabilitation of the Arm and Hand After Stroke

Conditions:   Stroke;   Hemiparesis
Intervention:   Device: IpsiHand Treatment
Sponsors:   Columbia University;   Neurolutions, Inc.
Not yet recruiting

Multicenter Study on the Efficacy of Transcranial Direct Current Stimulation (tDCS) in Post-stroke Motor Recovery

Conditions:   Stroke, Ischemic;   Stroke Hemorrhagic
Interventions:   Device: Anodal transcranial direct current stimulation (A-tDCS);   Device: Cathodal transcranial direct current stimulation (C-tDCS);   Device: Sham stimulation (sham-tDCS);   Behavioral: Neuromotor training
Sponsors:   IRCCS Centro San Giovanni di Dio Fatebenefratelli;   San Gerardo Hospital;   Maggiore Bellaria Hospital, Bologna;   Azienda Ospedaliero, Universitaria Pisana;   Fondazione Don Carlo Gnocchi Onlus;   Azienda Ospedaliera Universitaria Integrata Verona;   Azienda Unità Sanitaria Locale di Piacenza;   Azienda Ospedaliero Universitaria di Cagliari;   Ospedale Policlinico San Martino;   I.R.C.C.S. Fondazione Santa Lucia;   Catholic University of the Sacred Heart;   Istituti Clinici Zucchi
Recruiting

Performing a Low-dose, Whole-body Angiography as the First Element of an Imaging Assessment Following Stroke / TIA

Conditions:   Stroke;   Ischemic Attack, Transient
Interventions:   Other: Routine Imaging Assessment;   Device: LDWBA first (CT scan)
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Recruiting

Focal Muscular Vibration to Treat Upper Limb Spasticity in Stroke

Condition:   Stroke
Interventions:   Device: FMV_flex;   Device: FMV_ext
Sponsor:   Fondazione Don Carlo Gnocchi Onlus
Recruiting

Osmotic Agent Use in Middle Cerebral Artery Stroke

Conditions:   Ischemic Stroke;   MCA Infarction
Intervention:   Other: No intervention is planned, this will be a purely retrospective trial.
Sponsor:   University of Minnesota
Completed

The Effect of Vestibulo-ocular Reflex Improving Exercise on Gait and Balance Among Post Stroke Sub Acute Patients

Condition:   Stroke
Interventions:   Other: Physiotherapy including Vestibular rehabilitation;   Other: conventional Physiotherapy
Sponsor:   Prof. Dan Justo
Not yet recruiting

POSITIVE Stroke Clinical Trial

Condition:   Ischemic Stroke
Intervention:   Device: Endovascular Mechanical Thrombectomy
Sponsors:   Medical University of South Carolina;   Vanderbilt University
Terminated

Expressive Arts-based Intervention for Young and Pre-elderly Stroke Survivors

Condition:   Stroke
Intervention:   Behavioral: Expressive Arts Therapy
Sponsor:   The University of Hong Kong
Recruiting

StroCare - Optimised Cross-sectoral,Coordinated Treatment of Stroke Patients With Patient-orientated Outcome Measurement

Condition:   Stroke
Intervention:   Other: optimized cross-sectoral, structured and coordinated treatment pathway that integrates a patient-centred outcome evaluation
Sponsors:   Universitätsklinikum Hamburg-Eppendorf;   Albertinen Krankenhaus gGmbH;   Elbe Kliniken Stade-Buxtehude GmbH;   Reha Centrum Hamburg GmbH;   Klinikum Bad Bramstedt GmbH;   MediClin Klinikum Soltau GmbH;   VAMED Klinik Geesthacht;   VAMED Rehaklinik Damp;   BARMER Krankenkasse;   Lohmann und Birkner medizinisches ServiceCenter GmbH;   Forcare GmbH
Not yet recruiting

Effect of Pilates Training on Cognitive Functions in Patients With Stroke

Condition:   Stroke
Interventions:   Other: Pilates training;   Other: Conventional physical therapy
Sponsor:   October 6 University
Recruiting

Integrating Stroke Survivors Into Cardiac Rehabilitation

Condition:   Stroke
Intervention:   Behavioral: Cardiac Rehabilitation
Sponsors:   University of South Carolina;   Novant Health Heart and Vascular Institute;   American Physical Therapy Association
Active, not recruiting

A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel

Conditions:   Acute Ischemic Stroke;   Transient Ischemic Attack (TIA)
Interventions:   Drug: BMS-986177;   Other: Placebo;   Drug: Clopidogrel;   Drug: Aspirin
Sponsors:   Bristol-Myers Squibb;   Janssen, LP
Recruiting

Xingnaojing for Mild-to-severe Acute Ischemic Stroke

Conditions:   Acute Ischemic Stroke;   Stroke, Acute;   Stroke, Ischemic
Interventions:   Drug: Xingnaojing injection;   Drug: Xingnaojing placebo injection;   Other: Standard care
Sponsors:   Dongzhimen Hospital, Beijing;   Peking University Third Hospital;   Beijing Shuyi Hospital;   The Airport Hospital of Shunyi District Beijing;   Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine;   The NO.4 People's Hospital of Hengshui;   The Second Hospital of Hebei Medical University;   The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine;   The Affiliated Hospital of Shaanxi University of Chinese Medicine;   Tianshui Hospital of Traditional Chinese Medicine;   The Affiliated Hospital of Changzhi Academy of TCM;   Zibo Hospital of Traditional Chinese Medicine;   Yantai Yuhuangding Hospital;   Shandong University of Traditional Chinese Medicine;   Zhejiang Provincial Hospital of TCM;   Zhejiang Provincial Tongde Hospital;   Second Affiliated Hospital of Wenzhou Medical University;   People's Hospital of Quzhou;   Longhua Hospital;   The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine;   Taizhou Hospital of Traditional Chinese Medicine;   The First Affiliated Hospital of Guizhou University of TCM;   Guangzhou Hospital of Traditional Chinese Medicine;   The First Affiliated Hospital of Guangxi University of Chinese Medicine;   Liling Hospital of Traditional Chinese Medicine;   Hunan Academy of Traditional Chinese Medicine Affiliated Hospital;   Hubei Hospital of Traditional Chinese Medicine;   First Hospital of Jilin University;   Anshan Central Hospital;   The Affiliated Hospital of Liaoning University of TCM;   The First Hospital of Qiqihar City;   Haikou People's Hospital;   The Second People's Hospital of Anhui Province;   The Third Affiliated Hospital of Shenzhen University;   The third people's Hospital of Hubei Province;   The First Affiliated Hospital of Henan University of Traditional Chinese Medicine;   The Third Hospital of Xi'an City
Not yet recruiting

HD-tDCs to Improve Upper Extremity Function in Patients With Acute Middle Cerebral Artery Stroke

Condition:   Middle Cerebral Artery Stroke
Interventions:   Device: Soterix MxN Neuromodulation device;   Device: Sham Stimulation
Sponsor:   Milton S. Hershey Medical Center
Not yet recruiting

Efficacy of End-Effector Robot-Assisted Gait Training Combined With Robotic Balance Training in Subacute Stroke Patients

Condition:   Stroke
Interventions:   Device: GEO;   Device: GEO and HUNOVA
Sponsor:   Fondazione Don Carlo Gnocchi Onlus
Not yet recruiting

EMG-controlled Virtual Reality to Improve Upper Extremity Function in Chronic Stroke Patients

Conditions:   Stroke;   Upper Extremity Dysfunction
Intervention:   Device: Electromyography-controlled virtual and augmented reality using serious gaming
Sponsors:   Chalmers University of Technology;   Sahlgrenska University Hospital, Sweden;   Göteborg University
Not yet recruiting

Efficacy of Intravenous Tissue-type Plasminogen Activator on Acute Ischemic Stroke Patients With Large Vessel Occlusions

Conditions:   Stroke, Ischemic;   Stroke, Acute
Intervention:   Drug: Plasminogen Activators
Sponsor:   Ho Chi Minh City University of Medicine and Pharmacy
Recruiting

Efficacy of Sovateltide (PMZ-1620) in Patients of Acute Ischemic Stroke

Conditions:   Cerebral Ischemia;   Cerebral Infarction;   Stroke, Acute
Interventions:   Drug: Normal Saline along with standard treatment;   Drug: PMZ-1620 (sovateltide) along with standard treatment
Sponsor:   Pharmazz, Inc.
Recruiting

Neuroregeneration Enhanced by Transcranial Direct Current Stimulation (TDCS) in Stroke

Condition:   Stroke
Interventions:   Device: DC-Stimulator to apply tDCS;   Device: DC-Stimulator to apply Sham tDCS
Sponsor:   Universitätsklinikum Hamburg-Eppendorf
Active, not recruiting

To Investigate the Effects of Robotic-assisted Gait Training in Stroke Patients

Conditions:   Stroke;   Cerebrovascular Disorders
Interventions:   Other: virtual reality, robot assisted gait training;   Other: conventional treatment
Sponsor:   Gazi University
Active, not recruiting

Helping Stroke Patients With ThermoSuit Cooling

Conditions:   Stroke;   Brain Ischemia
Interventions:   Device: ThermoSuit Cooling Induction;   Drug: Magnesium Sulfate;   Drug: tPA;   Drug: Propofol;   Drug: Etomidate;   Procedure: Neurothrombectomy
Sponsors:   Life Recovery Systems;   Tulane University School of Medicine
Recruiting

The General Use of Robots in Stroke Recovery: the Anklebot

Condition:   Stroke
Intervention:   Device: seated robot-assisted ankle therapy
Sponsor:   Northwell Health
Completed

Treatment of Chronic Stroke With AMES + EMG Biofeedback

Conditions:   Stroke;   Plegia;   Paresis;   Cerebrovascular Accident
Intervention:   Device: AMES Therapy (assisted movement and enhanced sensation)
Sponsors:   AMES Technology;   Oregon Health and Science University;   Emory University;   Northwestern University
Completed

Effectiveness of FACoT for Individuals Post Stroke

Condition:   Stroke
Intervention:   Other: FacoT
Sponsors:   Bait Balev Hospital;   Tel Aviv University
Recruiting

Oral Neuromuscular Training in Stroke Patients With Dysphagia

Conditions:   Stroke;   Dysphagia
Interventions:   Behavioral: Oral neuromuscular training and orofacial sensory-vibration;   Behavioral: Orofacial sensory-vibration stimulation
Sponsors:   Umeå University;   Uppsala University
Recruiting

Novel Training Environment to Normalize Altered Finger Force Direction Post Stroke

Condition:   Stroke
Interventions:   Behavioral: 3D;   Behavioral: 1D
Sponsor:   VA Office of Research and Development
Not yet recruiting

Evaluation to Assess Safety and Tolerability of DM199 in Subjects With Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke
Interventions:   Drug: Recombinant human tissue kallikrein;   Other: Placebo
Sponsor:   DiaMedica Therapeutics Inc
Active, not recruiting

Effects of Mirror Therapy and Cognitive Therapeutic Exercise in Stroke Patients

Conditions:   Stroke;   Hemiparesis
Interventions:   Behavioral: Mirror therapy;   Behavioral: Cognitive therapeutic exercise
Sponsors:   Universidad de Burgos;   Castilla-León Health Service
Not yet recruiting

Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke

Condition:   Coronary Heart Disease (CHD)
Interventions:   Drug: Evolocumab;   Drug: Placebo
Sponsor:   Amgen
Recruiting

Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE)

Conditions:   Perinatal Stroke;   Hemiparesis
Interventions:   Behavioral: I-ACQUIRE - High Dosage;   Behavioral: I-ACQUIRE - Moderate Dosage;   Behavioral: Usual & Customary Treatment (U&CT)
Sponsors:   Virginia Polytechnic Institute and State University;   Ohio State University;   Nationwide Children's Hospital;   Stanford University;   University of Cincinnati;   Medical University of South Carolina
Recruiting

Resume Walking by an Interactive Mobile Robot of Rehabilitation After Vascular Stroke (Cerebral Vascular Stroke) in Combination With Traditional Reeducation

Condition:   Stroke Sequelae
Interventions:   Other: Clinical evaluation;   Other: Intervention - with Robot;   Other: Intervention - without Robot;   Other: quality of life assessment;   Other: assessment of the patient's satisfaction
Sponsor:   Rennes University Hospital
Not yet recruiting

Moving a Paralyzed Hand Through Use of a Brain-Computer Interface

Condition:   Stroke
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Center for Neuroscience and Regenerative Medicine (CNRM)
Terminated

Self-modulated Functional Electrical Stimulation in Chronic Stroke Patients With Severe and Moderate Upper Limb Paresis

Condition:   Stroke Rehabilitation
Interventions:   Device: Self-modulated functional electrical stimulation (SM-FES);   Other: Standard Care
Sponsors:   Intento SA;   Centre Hospitalier Universitaire Vaudois;   University Hospital, Geneva;   KLINIK BETHESDA Tschugg;   University Hospital Inselspital, Berne;   University of Bern;   Innosuisse - Suisse Innovation Agency
Recruiting

Dry Needling and Bobath Treatment Clinical Effects Focused on Stroke Patients

Conditions:   Ischemic Stroke;   Spasticity
Interventions:   Other: Dry needling in a myofascial trigger points area plus physical therapy based on Bobath concept;   Other: Dry needling in a non myofascial trigger points area plus physical therapy based on Bobath concept
Sponsor:   Universidad Rey Juan Carlos
Completed

Brain Machine Interface Control of an Robotic Exoskeleton in Training Upper Extremity Functions in Stroke

Conditions:   Stroke;   Hemiparesis
Intervention:   Device: MAHI EXO-II exoskeleton augmented with BMI system
Sponsors:   The University of Texas Health Science Center, Houston;   University of Houston;   The Methodist Hospital System;   National Institute of Neurological Disorders and Stroke (NINDS);   TIRR Memorial Hermann
Completed

Clinical Trial to Evaluate the Efficacy and Safety of JPI-289 in Patients With Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke
Interventions:   Drug: JPI-289 Low-dose;   Drug: JPI-289 High-dose;   Drug: Placebo
Sponsor:   Jeil Pharmaceutical Co., Ltd.
Recruiting

Comparing the Difference in Muscle Synergies Between Healthy Participants and Chronic Stroke Survivors

Condition:   Healthy
Intervention:   Other: Measurement of muscle activation.
Sponsors:   Chinese University of Hong Kong;   The Hong Kong Polytechnic University;   City University of Hong Kong;   Shanghai Jiao Tong University School of Medicine
Not yet recruiting

Effects rTMS Combined With Fluoxetine on Motor Recovery in Stroke Patients

Conditions:   Stroke;   Motor Function
Interventions:   Device: Active Repetitive Transcranial Magnetic Stimulation (rTMS);   Drug: Fluoxetine;   Device: Sham repetitive transcranial magnetic stimulation (rTMS);   Drug: Placebo Fluoxetine
Sponsor:   Spaulding Rehabilitation Hospital
Completed

Remote Ischaemic Conditioning for Fatigue After Stroke

Conditions:   Stroke, Ischemic;   Stroke Hemorrhagic;   Fatigue
Interventions:   Procedure: Remote Ischaemic Conditioning;   Procedure: Sham Intervention
Sponsor:   Sheffield Teaching Hospitals NHS Foundation Trust
Recruiting

Dual Transcranial Direct Current Stimulation (dTDCS)-Enhanced Therapy After Hemorrhagic Strokes and VEGF

Conditions:   Hemorrhagic Stroke;   Hemiparesis
Intervention:   Device: dual transcranial direct current stimulation
Sponsors:   University of Texas Southwestern Medical Center;   American Heart Association
Terminated

A Study to Evaluate the Safety and Effectiveness of Rivaroxaban (Xarelto) for Prevention of Stroke and Systemic Embolism in Indian Patients With Non-valvular Atrial Fibrillation (NVAF)

Condition:   Non-valvular Atrial Fibrillation (NVAF)
Intervention:   Drug: Rivaroxaban (Xarelto,Bay 59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting

The Effect of RIC on TIA/Stroke in Children With Moyamoya Disease

Conditions:   Moyamoya Disease;   TIA;   Children;   Stroke
Interventions:   Device: RIC group;   Device: Sham group
Sponsors:   Capital Medical University;   307 Hospital of PLA
Not yet recruiting

Endovascular Treatment Key Technique and Emergency Work Flow Improvement of Acute Ischemic Stroke (ANGEL-ACT): Phase Two

Condition:   Intracranial Artery Occlusion With Infarction (Disorder)
Intervention:   Behavioral: ANGEL Intervention Package and Toolbox
Sponsor:   Beijing Tiantan Hospital
Recruiting

Parent Therapist Partnership to Provide Early, Intensive Exercise in Perinatal Stroke

Condition:   Perinatal Stroke
Intervention:   Behavioral: Intensive exercise
Sponsors:   University of Alberta;   Brain Canada
Recruiting

pRESET for Occlusive Stroke Treatment

Conditions:   Brain Diseases;   Cardiovascular Diseases;   Central Nervous System Diseases;   Cerebrovascular Disorders;   Ischemia;   Nervous System Diseases;   Pathologic Processes;   Stroke, Ischemic;   Stroke, Acute;   Vascular Diseases
Interventions:   Device: Mechanical Thrombectomy using the pRESET Thrombectomy device;   Device: Mechanical Thrombectomy using the Solitaire Revascularization Device
Sponsor:   phenox Inc.
Recruiting

Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury

Condition:   Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury
Interventions:   Drug: NT 201;   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Recruiting

Stroke Recovery Initiative - Registry for Stroke Research Studies

Conditions:   Stroke;   Acute Stroke;   Ischemic Stroke;   Hemorrhagic Stroke;   Subarachnoid Hemorrhage;   Cerebral Ischemia;   Cerebral Infarction;   Cerebral Stroke;   Cerebral Vascular Accident
Intervention:  
Sponsor:   University of California, San Francisco
Recruiting

Robotic Rehabilitation and Cognitive Functions

Condition:   Stroke
Intervention:   Device: Robotic assisted intervention
Sponsor:   Fondazione Don Carlo Gnocchi Onlus
Not yet recruiting

Promoting Recovery Optimization With WALKing Exercise After Stroke

Condition:   Stroke
Interventions:   Behavioral: FAST;   Behavioral: FAST+SAM;   Behavioral: SAM
Sponsors:   University of Delaware;   University of Pennsylvania;   Christiana Care Health Services;   Indiana University
Recruiting

fMRI Neurofeedback for Motor Rehabilitation

Conditions:   Stroke;   fMRI
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Effects of Virtual Reality Based Rehabilitation in Acute Stroke Patients in an Inpatient Rehab Setting

Conditions:   Stroke Syndrome;   Hemiplegia
Intervention:   Device: Rapael
Sponsor:   Montefiore Medical Center
Recruiting

VNS-supplemented Motor Retraining After Stroke

Condition:   Stroke, Acute
Interventions:   Other: Training;   Other: Vagus Nerve Stimulation;   Other: Sham Stimulation
Sponsor:   University of Pittsburgh
Recruiting

Xarelto on Prevention of Stroke and Non-Central Nervous Systemic Embolism in Renally Impaired Korean Patients With Non-valvular Atrial Fibrillation

Condition:   Non-valvular Atrial Fibrillation (NVAF)
Intervention:   Drug: Rivaroxaban(Xarelto,BAY 59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting

The Effect of Trazodone on the Severity of Obstructive Sleep Apnea in Insomnic Stroke Patients With Depression

Conditions:   Sleep Apnea Syndromes;   Cerebral Infarction
Interventions:   Drug: Trazodone;   Drug: Placebo oral tablet
Sponsor:   Chang Gung Memorial Hospital
Recruiting

Stroke-like Migraine Attacks After Radiation Treatment (SMART) Syndrome Language Intervention

Conditions:   Migraine Disorders;   Aphasia
Intervention:   Behavioral: Language treatment
Sponsor:   Quality Living, Inc.
Completed

Mental Imagery Neurofeedback in Strokerehabilitation

Conditions:   Stroke;   Hemiparesis
Intervention:   Device: Mental imagery neurofeedback training
Sponsors:   Mälardalen University;   Danderyd Hospital;   Vinnova
Active, not recruiting

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy (CEA);   Device: Carotid Stenting (CAS);   Other: Intensive Medical Management - no CEA;   Other: Intensive Medical Management - no CAS
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Post Marketing Study to Evaluate the GCE Device

Condition:   Cerebral Stroke
Intervention:   Device: Geometric Clot Extractor (GCE) Device
Sponsor:   Neuravi Limited
Recruiting

Effects of Transcranial Direct Current Stimulation (tDCS) on Language

Conditions:   Stroke;   Aphasia
Interventions:   Device: Transcranial Direct Current Stimulation;   Device: Sham Transcranial Direct Current Stimulation;   Behavioral: Phonologic-Focused Speech Therapy;   Behavioral: Semantic-Focused Speech Therapy
Sponsor:   Medical College of Wisconsin
Not yet recruiting

Xarelto on Prevention of Stroke and Noncentral Nervous System Systemic Embolism in Treatment-naïve Asian Patients With Non-valvular Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, Bay59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

Shared Decision-Making: AFib 2gether Mobile App

Condition:   Atrial Fibrillation New Onset
Intervention:   Device: Afib 2gether TM Mobile Application
Sponsors:   University of Massachusetts, Worcester;   Pfizer
Recruiting

Effectiveness of Computerized Device New of Visual Motor Simulation Versus Mirror Therapy in Hemiplegic Patients.

Condition:   Stroke
Interventions:   Device: Intensive Visual Simulation 3 (IVS3) device;   Device: traditional Mirror Therapy (TM)
Sponsors:   Centre Hospitalier Universitaire de Saint Etienne;   Saint-Etienne Métropole
Recruiting

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention & Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Population Health Research Institute;   Janssen Research & Development, LLC
Active, not recruiting

Pleth Variability Index in Modified Prone Position or Knee-chest Position (Concord Position)

Conditions:   Fluid Responsiveness;   Modified Prone Position
Intervention:   Other: volume expansion
Sponsor:   Asan Medical Center
Recruiting

WATCH-TAVR, WATCHMAN for Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement

Conditions:   Atrial Fibrillation;   Aortic Valve Stenosis
Interventions:   Device: WATCHMAN;   Device: TAVR
Sponsors:   Samir Kapadia;   Boston Scientific Corporation;   The Cleveland Clinic
Recruiting

NBP in Adult Patients With Acute Ischemic Stroke (AIS)

Condition:   AIS
Interventions:   Drug: NBP Softgel Capsules;   Drug: Placebo
Sponsor:   CSPC-NBP Pharmaceutical Co., Ltd.
Recruiting

Alternative Therapies for Improving Motor Impairment, Fall-risk and Overall Physical Function

Conditions:   Chronic Stroke;   Healthy Aging
Interventions:   Behavioral: Cognitive-motor exergaming;   Behavioral: Conventional balance Training;   Behavioral: Dance Therapy for Stroke;   Behavioral: Dance Therapy for Older adults;   Behavioral: Home education for Older adults
Sponsors:   University of Illinois at Chicago;   National Institute on Aging (NIA)
Completed

Endovascular Therapy for Low NIHSS Ischemic Strokes

Condition:   Cerebral Ischemia
Interventions:   Device: Immediate mechanical thrombectomy(iMT) using EmboTrap II Revascularization Device;   Combination Product: Initial medical management (iMM)
Sponsors:   Emory University;   University of Calgary;   University of Cincinnati;   Heidelberg University
Not yet recruiting

RedStroke - Reducing Europe's Stroke Incidence

Condition:   Atrial Fibrillation
Interventions:   Device: App measurement;   Device: 14 day Holter ECG
Sponsors:   University Hospital, Basel, Switzerland;   European Union;   Preventicus GmbH
Recruiting

Hemiparetic Arm Robotic Mobilization With Non Invasive Electrical Stimulation

Conditions:   Stroke;   Paresis;   Upper Extremity Paralysis
Interventions:   Device: Real dual tDCS + Robotic Arm Therapy;   Device: SHAM tDCS + Robotic Arm Therapy
Sponsors:   I.R.C.C.S. Fondazione Santa Lucia;   Campus Bio-Medico University
Enrolling by invitation

Noninvasive VNS to Facilitate Excitability in Motor Cortex

Conditions:   Stroke;   Stroke Sequelae;   Motor Activity
Interventions:   Device: Transcranial Magnetic Stimulation;   Device: transcutaneous auricular vagus nerve stimulation (taVNS)
Sponsors:   Medical University of South Carolina;   National Institutes of Health (NIH)
Not yet recruiting

Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity

Conditions:   Overweight;   Obesity
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

Earlier Mobilization Post Acute Thrombectomy

Conditions:   Stroke;   Stroke, Acute;   Stroke, Ischemic
Intervention:   Behavioral: Mobilization
Sponsor:   Brian Silver
Not yet recruiting

Earlier Mobilization Post Acute Thrombolysis

Conditions:   Stroke;   Stroke, Acute;   Stroke, Ischemic
Intervention:   Behavioral: Mobilization
Sponsor:   Brian Silver
Not yet recruiting

Clinical Study to Evaluate the Safety and Effectiveness of MER® Stents in Carotid Revascularisation.

Condition:   Carotid Artery Stenosis
Intervention:   Device: MER
Sponsors:   Balton Sp.zo.o.;   KCRI
Completed

Translation and Validation Fugl-Meyer in Italian Language

Condition:   Validation Fugl Meyer Scale in Italian
Intervention:  
Sponsors:   Fondazione Don Carlo Gnocchi Onlus;   Göteborg University
Active, not recruiting

Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Biological: Apolipoprotein A-I [human] (apoA-I);   Other: Placebo
Sponsor:   CSL Behring
Recruiting

Tenecteplase in Stroke Patients Between 4 and 24 Hours

Condition:   THROMBOLYSIS
Interventions:   Biological: Tenecteplase;   Other: Placebo
Sponsor:   Genentech, Inc.
Recruiting

A Nationwide Observational Study Looking at Effectiveness and Bleeding Complications of NOACs vs. VKA in Non-valvular Atrial Fibrillation Patients.

Condition:   Non-valvular Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Apixaban (Eliquis);   Drug: Dabigatran etexilate (Pradaxa);   Drug: Warfarin (Marevan)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

Cerebral Oxygen Metabolism in Children

Conditions:   Sickle Cell Disease;   Cerebral Stroke
Intervention:   Other: Carbon Dioxide
Sponsor:   Washington University School of Medicine
Recruiting

VNS-induced Corticospinal Plasticity

Condition:   Stroke
Interventions:   Other: Paired-Associative Stimulation (PAS);   Other: Vagus Nerve Stimulation (VNS);   Other: Sham Stimulation
Sponsor:   University of Pittsburgh
Recruiting

FIrst-Pass Reperfusion With the NeVa Stent-Retriever Trial

Condition:   Acute Ischemic Stroke
Interventions:   Device: NeVa Stent Retrievers;   Device: Solitaire Stent Retrievers
Sponsor:   Vesalio
Not yet recruiting

Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

Conditions:   Atrial Fibrillation;   Stroke;   Bleeding
Interventions:   Drug: Antiplatelet-only strategy;   Drug: Oral Anticoagulant plus background antiplatelet therapy
Sponsors:   Icahn School of Medicine at Mount Sinai;   National Heart, Lung, and Blood Institute (NHLBI);   Vanderbilt University Medical Center
Not yet recruiting

GLORIA-AF Registry Program - Second and Third Phases

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Spaced Versus Massed Skill Learning

Condition:   Healthy Volunteer
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia

Conditions:   Aphasia;   Stroke
Interventions:   Device: Anodal transcranial direct current stimulation;   Device: Sham transcranial direct current stimulation;   Behavioral: Speech-Language Therapy (SLT)
Sponsor:   Louisiana State University and A&M College
Not yet recruiting

Non-interventional, Retrospective Cohort Study to Explore OAC Treatment in Korea

Condition:   Atrial Fibrillation
Interventions:   Drug: Apixaban;   Drug: Dabigatran;   Drug: Rivaroxaban;   Drug: warfarin;   Drug: Antiplatelets
Sponsor:   Pfizer
Completed

Pipeline Flex With SHield Technology Embolization - An International MulticEnter ObservationaL Post Market StuDy

Condition:   Intracranial Aneurysm
Intervention:   Device: Pipeline™ Flex Embolization Device with Shield Technology™
Sponsors:   Medtronic Neurovascular Clinical Affairs;   Medtronic Bakken Research Center
Completed

Safety and Efficacy Comparison Of Two TAVI Systems in a Prospective Randomized Evaluation II

Condition:   Aortic Valve Stenosis
Interventions:   Device: Symetis ACURATE neo™ transfemoral TAVI system;   Device: Medtronic CoreValve Evolut R TAVI System
Sponsors:   Ceric Sàrl;   Symetis SA
Active, not recruiting

Safety and Efficacy Continued Access Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in Very High Risk Subjects and High Risk Subjects Who Need Aortic Valve Replacement

Condition:   Severe Aortic Stenosis
Intervention:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting

Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement

Condition:   Severe Aortic Stenosis
Interventions:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI);   Device: Surgical Aortic Valve Replacement (SAVR)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting

The TransCatheter Valve and Vessels Trial

Conditions:   Aortic Stenosis;   Multi Vessel Coronary Artery Disease;   TAVI;   CABG;   PCI;   Fractional Flow Reserve
Interventions:   Device: FFR-guided PCI and TAVI;   Device: CABG and SAVR
Sponsors:   Maatschap Cardiologie Zwolle;   Medtronic
Recruiting

Upper Limb Treatment With "Gloreha Aria" in the Hemiplegic Patients

Conditions:   Hemiplegia and/or Hemiparesis Following Stroke;   Upper Extremity Injury
Interventions:   Device: Gloreha Aria;   Other: Usual care
Sponsor:   Istituti Clinici Scientifici Maugeri SpA
Recruiting

Assessing Clinical Endpoints and Biomarkers in Myotonic Dystrophy Type-1 and Type 2 (ASCEND-DM)

Conditions:   Myotonic Dystrophy Type-1;   Myotonic Dystrophy Type-2
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Evaluation of Transcatheter Aortic Valve Replacement Compared to SurveilLance for Patients With AsYmptomatic Severe Aortic Stenosis

Conditions:   Aortic Stenosis;   Heart Diseases
Intervention:   Device: Edwards SAPIEN 3 THV
Sponsor:   Edwards Lifesciences
Recruiting

Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders

Conditions:   Alzheimer's Disease;   Dementia;   Down's Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Infants With Spinal Muscular Atrophy Type I

Condition:   Spinal Muscular Atrophy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Genetics of Motor Learning

Conditions:   Parkinson s Disease;   Dystonic Disorders;   Focal Dystonia;   Movement Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

PCI vs. CABG in the Treatment of Unprotected Left Main Stenosis

Condition:   Coronary Artery Disease
Interventions:   Procedure: Percutaneous coronary intervention;   Procedure: Coronary artery bypass graft operation
Sponsor:   Evald Hoej Christiansen
Active, not recruiting

Neural Dynamics and Connectivity in Response Inhibition and Traumatic Brain Injury

Conditions:   Traumatic Brain Injury;   Stroke;   Headache;   PTSD
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   United States Department of Defense;   Center for Neuroscience and Regenerative Medicine (CNRM);   National Institutes of Health Clinical Center (CC)
Completed

BedMed-Frail: Does the Potential Benefit of Bedtime Antihypertensive Prescribing Extend to Frail Populations?

Conditions:   Hypertension;   Dementia
Intervention:   Other: Bedtime administration of the participant's pre-existing antihypertensive medications
Sponsors:   University of Alberta;   Alberta Innovates Health Solutions;   Canadian Institutes of Health Research (CIHR);   EnACt
Not yet recruiting

Extended-Duration Low-Dose Apixaban to Prevent Recurrence in High-Risk Patients With Provoked Venous Thromboembolism

Conditions:   Deep Vein Thrombosis;   Pulmonary Embolism;   Venous Thromboembolism
Interventions:   Drug: Apixaban 2.5 MG;   Drug: Placebo oral tablet
Sponsor:   Brigham and Women's Hospital
Not yet recruiting

Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System

Condition:   Healthy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Active, not recruiting

Restorative Neuromodulation for Lower Extremity Functions

Conditions:   Spinal Cord Injuries;   Stroke;   Paralysis
Intervention:   Device: trans-spinal Electrical Stimulation (tsES)
Sponsors:   The Hong Kong Polytechnic University;   University of California, Los Angeles;   Hospital Authority, Hong Kong
Recruiting

ASSIST Registry Studying Various Operator Techniques

Condition:   Ischemic Stroke
Intervention:   Device: Mechanical Thrombectomy
Sponsor:   Stryker Neurovascular
Recruiting

The Effect of Antihypertensive Medication Timing on Morbidity and Mortality

Condition:   Hypertension
Interventions:   Other: Use of blood pressure lowering medication at bedtime;   Other: Use of blood pressure lowering medication in the morning
Sponsors:   University of Alberta;   Alberta Innovates Health Solutions;   Alberta Health Services
Recruiting

Clinical Feasibility of Transcranial Direct Current Stimulation [tDCS] With Standard Aphasia Therapy

Conditions:   Aphasia;   Stroke
Interventions:   Device: Anodal transcranial direct current stimulation;   Device: Sham transcranial direct current stimulation;   Behavioral: Speech-language therapy
Sponsor:   Louisiana State University and A&M College
Enrolling by invitation

PACESETTER: Program to Avoid Cerebrovascular Events Through Systematic Electronic Tracking and Tailoring of an Eminent Risk-factor

Conditions:   Blood Pressure;   Hypertension;   Mhealth
Intervention:   Device: PACESETTER
Sponsors:   Northern California Institute of Research and Education;   University of South Carolina;   Prisma Health-Upstate;   Medical University of South Carolina
Not yet recruiting

Long-Term Improvement in Motor Learning by Transcranial Direct Current Stimulation

Condition:   Healthy Volunteers
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   United States Department of Defense;   Center for Neuroscience and Regenerative Medicine (CNRM);   National Institutes of Health Clinical Center (CC)
Completed

Assessment Effectiveness of the Leap Motion Capture® System on the Functionality of the Upper Limb in Acquired Brain Injury

Conditions:   Stroke;   Treatment Adherence;   Patient Satisfaction;   Brain Injuries, Traumatic
Interventions:   Other: Conventional therapy;   Other: Leap motion plus conventional therapya
Sponsor:   Universidad Rey Juan Carlos
Active, not recruiting

Arterial Stiffness and Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Diagnostic Test: Carotid Ultrasound
Sponsor:   Mayo Clinic
Recruiting

Novel Head Protection Prototype Device for Decompression Craniectomy

Conditions:   Brain Injuries;   Stroke
Intervention:   Device: Head protection prototype device
Sponsors:   Tan Tock Seng Hospital;   Creatz3D
Recruiting

Anakinra for the Treatment of Chronically Inflamed White Matter Lesions in Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:   Drug: Anakinra
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Technical Development of Clinical Laboratory Studies

Condition:   Healthy Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting

Neurophysiology of Surround Inhibition in the Human Motor Cortex

Condition:   Normal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31

Condition:   Hereditary Spastic Paraplegia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Myalgic Encephalomyelitis Chronic Fatigue at the National Institutes of Health

Condition:   Chronic Fatigue Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

Condition:   Epilepsy
Intervention:   Drug: Mangafodipir
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection

Conditions:   HIV Infections;   Neurologic Disorders
Intervention:   Drug: Anakinra
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Johns Hopkins University
Terminated

Inflammatory and Infectious Diseases of the Nervous System

Condition:   Brain Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Oral Guanabenz for Multiple Sclerosis

Conditions:   Multiple Sclerosis, Relapsing-Remitting;   Multiple Sclerosis
Intervention:   Drug: Guanabenz
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Physiological and Psychosomatic Effects of Exposure to MRI Scanning Environment

Condition:   Healthy Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Withdrawn

Comparison Between NAVA and PSV in Neurocritical Patients

Conditions:   Neuro: Cerebrovascular Accident;   Trauma, Head
Intervention:   Other: NAVA vs PSV - TCCD
Sponsor:   Azienda Ospedaliero Universitaria Maggiore della Carita
Recruiting

Clinical Autonomic Disorders: A Training Protocol

Conditions:   Chronic Fatigue Syndrome;   Pseudopheochromocytoma;   Healthy Volunteers;   Neurocardiogenic Syncope;   Postural Tachycardia Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Study of Hepatic Function in Patients With Spinal and Bulbar Muscular Atrophy

Conditions:   Spinal and Bulbar Muscular Atrophy;   Motor Neuron Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database

Condition:   Epilepsy
Interventions:   Device: MRI;   Device: MEG
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk

Conditions:   Type 2 Diabetes Mellitus;   Chronic Kidney Diseases
Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: Placebo
Sponsor:   Sanofi
Active, not recruiting

Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation

Conditions:   Amyotrophic Lateral Sclerosis;   Frontotemporal Lobar Degeneration
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting

Electrical Impedance Myography: Exploratory Studies in Healthy People and People With Neuromuscular Disorders

Conditions:   Neuromuscular Disease;   Motor Neuron Disease;   Inherited Neuromuscular Conditions;   Inherited Neuropathies
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Imaging Studies of Cognitive Impairment in Parkinson s Disease

Conditions:   Parkinson Disease;   Dementia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Cerebrospinal Fluid Collection and Repository Storage

Condition:   Nervous System Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Deep Brain Stimulation for Refractory Alcoholism

Condition:   Alcoholism
Intervention:   Procedure: Implantation of Deep Brain Stimulation
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Withdrawn

Buspirone Therapy for Localized Epilepsy

Conditions:   Anxiety Disorder;   Seizures;   Epilepsy;   Partial Epilepsy;   Depression
Intervention:   Drug: Buspirone
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Combined Deep Brain Stimulation for Parkinson's Disease

Condition:   Parkinson Disease
Intervention:   Procedure: DBS Surgery
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Withdrawn

Octanoic Acid for Essential Tremor

Condition:   Essential Tremor
Intervention:   Drug: Octanoic Acid
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Effect of Functional Exercise in Patients With Spinal Bulbar Muscular Atrophy

Condition:   Motor Neuron Disease
Interventions:   Behavioral: A functional exercise program;   Behavioral: A stretching exercise program
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Structural and Functional Neuroimaging Studies of Combat Veterans

Conditions:   Traumatic Brain Injury;   PTSD
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Center for Neuroscience and Regenerative Medicine (CNRM)
Completed

Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients

Conditions:   Neoplasms;   Nervous System Disease;   Vestibular Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Ethanol Response in Essential Tremor: Clinical and Neurophysiological Correlates

Condition:   Essential Tremor
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

SMN Copy Number Distribution in Mali, West Africa

Condition:   Spinal Muscular Atrophy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Cerebral Activity Related to Primary Motor Stereotypies in Children: An EEG Study.

Condition:   Movement Disorder
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Recording and Modulation of Neuronal Mechanisms During Operant Conditioning: a MEG Study

Condition:   Central Nervous System
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Prognostic Factors and Management of Blood Pressure in Patients With Acute Spontaneous Intracerebral Hemorrhage.

Conditions:   Intra Cerebral Hemorrhage;   Hypertension
Intervention:   Diagnostic Test: Modified Rankin Scale (mRS)
Sponsor:   Mansoura University Hospital
Completed

GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Depression;   Depressive Disorder, Major
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

CORonary Diet Intervention With Olive Oil and Cardiovascular PREVention

Conditions:   Myocardial Infarction;   Unstable Angina;   Malignancy;   Cognitive Decline;   Diabetes Mellitus;   Metabolic Syndrome
Interventions:   Behavioral: Mediterranean Diet;   Behavioral: Low Fat Diet
Sponsor:   Hospital Universitario Reina Sofia de Cordoba
Active, not recruiting

Predictive Value of Neovascularization Within Asymptomatic Carotis Stenosis on CEUS

Condition:   Carotid Stenosis
Intervention:  
Sponsors:   University Hospital, Basel, Switzerland;   Swiss National Science Foundation
Recruiting

Effect of Reward on Learning in Motor Cortex

Condition:   Healthy
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   United States Department of Defense;   National Institutes of Health Clinical Center (CC);   Center for Neuroscience and Regenerative Medicine (CNRM)
Completed

Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM

Conditions:   Glioblastoma;   Glioblastoma Multiforme;   GBM;   Brain Cancer
Intervention:   Procedure: Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB)
Sponsor:   Northwell Health
Recruiting

Language Mapping in Patients With Epilepsy

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Partial Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Autoimmunity in Neurologic Complications of Celiac Disease

Condition:   Ataxia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Relationship of HHV-6B Virus to Seizures and Brain Injury

Conditions:   Epilepsy;   HHV6B Infection
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Brain Changes in Blepharospasm

Conditions:   Dystonia;   Focal Dystonia;   Cerebellar Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Brain Peripheral Benzodiazepine Receptors in Patients With Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:   Radiation: [(11)C]PBR28
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Detecting a Reward Signal in the Motor Cortex

Condition:   Healthy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Biomarkers in Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Long-Term Motor Learning in Focal Hand Dystonia

Condition:   Focal Hand Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Reference Values for Plasma Catechols

Conditions:   Healthy Volunteers;   Normal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Patient Registry for Patients With Chronic Subdural Hematoma

Condition:   Hematoma, Subdural, Chronic
Intervention:  
Sponsor:   Heinrich-Heine University, Duesseldorf
Not yet recruiting

Evaluation of Primary Chronic Autonomic Failure

Condition:   Autonomic Nervous System Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Coronary Hybrid Revascularisation Study

Condition:   Significant Coronary Artery Disease
Intervention:   Procedure: Combined CABG and PCI
Sponsor:   Aarhus University Hospital Skejby
Active, not recruiting

A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo
Sponsor:   Novo Nordisk A/S
Recruiting

Magnetic Resonance Spectroscopy to Evaluate Tourette s Syndrome

Condition:   Tourette Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Phenotype/Genotype Correlations in Movement Disorders

Condition:   Movement Disorder
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Screening and Natural History: Primary Lateral Sclerosis and Related Disorders

Condition:   Primary Lateral Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Evaluation and Treatment of Patients With Epilepsy

Condition:   Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Study of New Magnetic Resonance Imaging Methods of the Brain

Conditions:   Healthy;   Magnetic Resonance Imaging;   Adult;   Brain Mapping;   fMRI
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Study of Inherited Neurological Disorders

Conditions:   Motor Neuron Disease;   Muscular Disease;   Muscular Dystrophy;   Peripheral Nervous System Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Evaluation of Patients With HAM/TSP

Conditions:   HTLV-I Infection;   Tropical Spastic Paraparesis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Botulinum Toxin for the Treatment of Involuntary Movement Disorders

Conditions:   Chorea;   Drug Induced Dyskinesia;   Movement Disorder;   Muscular Disease;   Tic Disorder
Intervention:   Other: Botulinum Toxin
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Perioperative Antiplatelet Therapy in Patients With Drug-eluting Stent Undergoing Noncardiac Surgery

Condition:   Antiplatelet Drugs
Interventions:   Drug: Aspirin only;   Drug: No antiplatelet therapy
Sponsors:   Jung-min Ahn;   CardioVascular Research Foundation, Korea
Recruiting

Evaluation of Valiant Mona LSA

Condition:   Aortic Aneurysm, Thoracic, Chronic Type B Dissection
Intervention:   Device: Valiant Mona LSA Thoracic Stent Graft System
Sponsor:   Medtronic Endovascular
Active, not recruiting

Stereotactic, Robot-assisted Intracerebral Hemorrhage Clot Evacuation

Condition:   Intracerebral Hematoma
Interventions:   Procedure: Intracerebral catheter placement;   Device: Robot-assisted intracerebral catheter
Sponsors:   Zimmer Biomet;   University of Pittsburgh Medical Center
Suspended

Safety and Efficacy of RIC in Pediatric Moyamoya Disease Patients Treated With Revascularization Therapy

Conditions:   Moyamoya Disease;   Pediatric
Interventions:   Device: RIC group;   Device: sham group
Sponsor:   Capital Medical University
Not yet recruiting

Evaluation of the Safety and Potential Therapeutic Effects After Intravenous Transplantation of Cordstem-ST in Patients With Cerebral Infarction

Condition:   Cerebral Infarction
Interventions:   Biological: Cordstem-ST;   Biological: Placebo
Sponsor:   CHABiotech CO., Ltd
Completed

Hospital-Community-Family-Care Management Platform for Atrial Fibrillation (HCF-CMP-AF)

Conditions:   Telemedicine;   Atrial Fibrillation
Interventions:   Other: Hospital-Community-Family-Care Management Platform Online;   Other: Subjects with AF conventional treatment
Sponsor:   Northern Jiangsu Province People's Hospital
Recruiting

Feasibility Study of the Intravascular Ventricular Assist System (iVAS)

Conditions:   Heart Failure NYHA Class III;   Heart Failure NYHA Class IV
Intervention:   Device: intravascular ventricular assist system (iVAS)
Sponsor:   NuPulseCV
Recruiting

Randomised Evaluation of Sodium Dialysate Levels on Vascular Events

Condition:   End-Stage Kidney Disease
Interventions:   Other: Default dialysate sodium concentration of 137mmol/l;   Other: Default dialysate sodium concentration of 140mmol/l
Sponsors:   The George Institute;   Australasian Kidney Trials Network
Recruiting

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Conditions:   Acute Coronary Syndrome;   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Active, not recruiting

Cost-effectiveness and Cost-utility of Liberal vs Restrictive Red Blood Cell Transfusion Strategies in Patients With Acute Myocardial Infarction and Anaemia.

Conditions:   Myocardial Infarction;   Anemia;   Blood Transfusion
Interventions:   Procedure: Restrictive transfusion;   Procedure: Liberal transfusion;   Biological: red blood transfusion
Sponsor:   Assistance Publique - Hôpitaux de Paris
Active, not recruiting

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Germany)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI

Conditions:   Cognition Disorder;   Attention Deficit Disorder;   Traumatic Brain Injury
Intervention:   Drug: Methylphenidate
Sponsors:   University of Pennsylvania;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxoban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Active, not recruiting

Fingolimod as a Treatment of Cerebral Edema After Intracerebral Hemorrhage

Conditions:   Intracerebral Hemorrhage;   Cerebral Edema;   Stroke Hemorrhagic;   Intracerebral Hemorrhage, Hypertensive;   Intracerebral Hemorrhage Intraparenchymal
Interventions:   Drug: Fingolimod 0.5 mg;   Drug: Placebo;   Other: Standard of care
Sponsor:   Wake Forest University Health Sciences
Not yet recruiting

Effect of Efpeglenatide on Cardiovascular Outcomes

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Efpeglenatide (SAR439977);   Drug: Placebo
Sponsor:   Sanofi
Active, not recruiting

Early Versus Emergency Left Ventricular Assist Device Implantation in Patients Awaiting Cardiac Transplantation

Condition:   End Stage Heart Disease
Intervention:   Device: Early VAD implantation
Sponsors:   German Heart Institute;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK);   Helmholtz Zentrum München;   University Medicine Greifswald;   University of Göttingen
Recruiting

Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer

Conditions:   Intractable Pain;   Palliative Care
Intervention:   Drug: Intrathecal Resiniferatoxin
Sponsors:   National Institute of Dental and Craniofacial Research (NIDCR);   National Institute of Neurological Disorders and Stroke (NINDS);   Sorrento Therapeutics, Inc.
Recruiting

Individualized Physical Activity and Carotid Plaque Instability

Condition:   Carotid Atherosclerosis
Interventions:   Device: individualized home-based physical activity;   Other: MRI;   Biological: blood sampling;   Other: Questionnaires;   Other: 6-minute walk test
Sponsor:   Hospices Civils de Lyon
Not yet recruiting

A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Advanced Prostate Cancer and Cardiovascular Disease

Condition:   Prostate Cancer
Interventions:   Drug: Degarelix;   Drug: Leuprolide
Sponsors:   Ferring Pharmaceuticals;   Memorial Sloan Kettering Cancer Center;   Duke Clinical Research Institute
Recruiting

Chronic Kidney Disease (CKD) Platelet Study

Conditions:   Chronic Kidney Diseases;   Heart Attack;   Stroke, Ischemic
Interventions:   Drug: Ticagrelor 90mg;   Drug: Clopidogrel 75mg;   Drug: Aspirin 81 mg
Sponsors:   University of Arkansas;   American Society of Nephrology
Recruiting

Medtronic CoreValve Evolut R U.S. Clinical Study

Condition:   Aortic Stenosis
Intervention:   Device: CoreValve Evolut R TAVR system
Sponsor:   Medtronic Cardiovascular
Active, not recruiting

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Warfarin;   Drug: Antiplatelet drugs
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

Effects of Aerobic Dance Based Exercise Program After Surgery in Obeses Awating Bariatric Surgery

Conditions:   Morbid Obesity;   Bariatric Surgery Candidate;   Exercise;   Obesity
Interventions:   Other: Exercise treatment;   Other: Counselling
Sponsor:   Istanbul University-Cerrahpasa
Not yet recruiting

Trevo® Retriever Registry (China)

Condition:   Real World Data in China
Intervention:   Device: Trevo® Retriever
Sponsor:   Stryker Neurovascular
Recruiting

CoreValve® System Australia/New Zealand Clinical Study

Condition:   Aortic Valve Stenosis
Intervention:   Device: Medtronic CoreValve® System
Sponsors:   Medtronic Cardiovascular;   Medtronic Australasia
Completed

S 48168 (ARM 210) for the Treatment of RYR1-related Myopathies (RYR1-RM)

Condition:   RYR-1 Myopathy
Intervention:   Drug: S48168
Sponsors:   Armgo Pharma, Inc.;   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Nursing Research (NINR);   Celerion
Recruiting

Sildenafil To Prevent Clot

Conditions:   Thrombosis;   Hemolysis
Interventions:   Drug: Sildenafil;   Drug: Placebo Oral Tablet
Sponsor:   Montefiore Medical Center
Recruiting

Genetic Factors in Atherosclerosis

Condition:   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Completed

HW006 LATERAL Thoracotomy

Condition:   Left Sided Heart Failure
Interventions:   Device: HeartWare HVAD;   Procedure: Thoracotomy
Sponsors:   Medtronic Cardiac Rhythm and Heart Failure;   INTERMACS
Completed

Efficacy and Safety Study to Evaluate Vadadustat for the Correction of Anemia in Subjects With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)

Conditions:   Anemia;   Non-dialysis-dependent Chronic Kidney Disease
Interventions:   Drug: vadadustat;   Drug: darbepoetin alfa
Sponsor:   Akebia Therapeutics
Active, not recruiting

Rheumatic Heart Disease School Project

Condition:   Rheumatic Heart Disease
Intervention:   Diagnostic Test: Echocardiography
Sponsors:   University Hospital Inselspital, Berne;   B.P. Koirala Institute of Health Sciences
Completed

Visceral Manifold Study for the Repair of TAAA

Condition:   Thoracoabdominal Aortic Aneurysms
Intervention:   Device: TAAA Debranching Stent Graft System
Sponsors:   University of South Florida;   Medtronic;   Sanford Health
Recruiting

Blood Markers of Inflammation, Blood Clotting and Blood Vessel Function in HIV-infected Adults

Conditions:   Inflammation;   Pathologic Processes
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting

Effects of Vitamin D and Fish Oil on the Kidney in Hypertensives

Conditions:   Hypertension;   Kidney Diseases
Interventions:   Dietary Supplement: Vitamin D3;   Drug: Omega-3 Fatty acids;   Dietary Supplement: Vitamin D3 placebo;   Dietary Supplement: Fish oil placebo
Sponsors:   Albert Einstein College of Medicine;   Brigham and Women's Hospital;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting

Natural History of Optic Neuritis

Condition:   Multiple Sclerosis
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   National Eye Institute (NEI)
Completed

Nutrition Intervention Trials in Linxian Follow-up Study

Conditions:   Esophageal Cancer;   Gastric Cancer
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

Relating Genetic and Environmental Risk Scores to Multiple Sclerosis Susceptibility

Condition:   Multiple Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Functional Imaging in the Acute Phase of Transient Ischemic Attacks

Condition:   Transient Ischemic Attack
Intervention:   Diagnostic Test: Functional Magnetic Resonance Imaging
Sponsor:   Centre Hospitalier Universitaire de Besancon
Recruiting

Low INR to Minimize Bleeding With Mechanical Valves Trial

Conditions:   Bleeding Post-mechanical Valve Replacement;   Thromboembolism Post-mechanical Valve Replacement
Intervention:   Drug: Warfarin
Sponsor:   McMaster University
Recruiting

Lithium Treatment for Patients With Spinocerebellar Ataxia Type I

Condition:   Spinocerebellar Ataxia Type I
Intervention:   Drug: Lithium Carbonate
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Characteristics of Parkinson s Disease Associated With the LRRK-2 Gene Mutation

Condition:   Parkinson Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Cardiac Output Monitoring in Critically Ill Patient Undergoing Intubation

Condition:   Hypotension
Intervention:   Device: NICOM (Non invasive cardiac output monitor)
Sponsor:   Mayo Clinic
Recruiting

Aspirin (ASA) Therapy and Preeclampsia Prevention

Condition:   Preeclampsia
Interventions:   Drug: Aspirin 81 mg Enteric Coated Tab - 1 tablet;   Drug: Aspirin 81 mg Enteric Coated Tab - 2 tablets
Sponsor:   University of Tennessee
Not yet recruiting

Revascularisation or Medical Therapy in Elderly Patients With Acute Anginal Syndromes

Condition:   Acute Coronary Syndromes
Interventions:   Drug: Conservative Arm;   Procedure: Invasive Arm
Sponsors:   Brighton and Sussex University Hospitals NHS Trust;   Medtronic Vascular
Active, not recruiting

The Role of Gut Microbiota in Hypertension

Condition:   Hypertension
Intervention:   Other: Stool Sample and Blood Sample
Sponsors:   University of Florida;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Pilot Study of Vitamin D Screening Use in Peripheral Arterial Disease Patient Over Maximum Distance Walking

Condition:   Peripheral Arterial Disease
Intervention:   Drug: Cholecalciferol
Sponsor:   University Hospital, Angers
Recruiting

Brilinta Clinical Experience Investigation

Condition:   Acute Coronary Syndrome, Old Myocardial Infarction
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Evaluation of Transcutaneous Trigeminal Nerve Stimulation for Prevention of Cerebral Vasospasm After Subarachnoid Haemorrhage

Condition:   Subarachnoid Haemorrhage (SAH)
Intervention:   Device: Transcutaneous Electrical Nerve Stimulation (TENS)
Sponsor:   Poitiers University Hospital
Completed

Emotional Prosody Treatment in Parkinson's

Condition:   Parkinson Disease
Intervention:   Behavioral: Emotional prosodic treatment
Sponsor:   VA Office of Research and Development
Completed

Secondary Prevention of Atrial Fibrilation

Conditions:   Atrial Fibrillation;   Risk Factors;   Risk Reduction Behavior
Interventions:   Device: AliveCor mobile ECG cardiac monitor;   Behavioral: AF Program;   Other: Standard of care
Sponsors:   Boston Medical Center;   National Institutes of Health (NIH)
Enrolling by invitation

Addressing Hypertension Care in Africa

Conditions:   Hypertension;   Diabetes;   Telemedicine
Interventions:   Behavioral: Enhanced Usual Care Group;   Other: Usual Care Group
Sponsors:   Johns Hopkins University;   Johns Hopkins Alliance for a Healthier World
Recruiting

MOMENTUM 3 IDE Clinical Study Protocol

Condition:   Advanced Refractory Left Ventricular Heart Failure
Interventions:   Device: HeartMate 3 LVAS;   Device: HeartMate II LVAS
Sponsors:   Abbott Medical Devices;   Thoratec Corporation
Completed

The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments

Conditions:   Nicotine Dependence, Cigarettes;   Nicotine Withdrawal
Intervention:   Behavioral: Quit Card Intervention (QCI)
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research (CIHR)
Not yet recruiting

Safety and Performance of the Neuroform Atlas™ Stent System

Condition:   Intracranial Aneurysm
Intervention:   Device: Neuroform Atlas Stent System
Sponsor:   Stryker Neurovascular
Not yet recruiting

Coronary Calcium Scoring Versus Standard Care for Emergency Department Chest Pain Patients

Condition:   Chest Pain
Interventions:   Device: Coronary Calcium Scoring;   Procedure: Standard Care
Sponsor:   Montefiore Medical Center
Not yet recruiting

Southeastern Collaboration to Improve Blood Pressure Control

Condition:   Hypertension
Interventions:   Behavioral: Practice Facilitation;   Behavioral: Peer Coach;   Behavioral: Enhanced usual care
Sponsor:   University of Alabama at Birmingham
Recruiting

Randomized Study for the Optimal Treatment of Symptomatic Patients With Low Gradient Severe Aortic Valve Stenosis and Preserved Left Ventricular Ejection Fraction

Condition:   Aortic Valve Stenosis
Interventions:   Procedure: aortic valve replacement;   Other: strict clinical surveillance
Sponsor:   Rennes University Hospital
Recruiting

The Improving Cancer Aftercare Study.

Conditions:   Colorectal Cancer;   Prostate Cancer
Intervention:   Other: Interview
Sponsors:   University of Aberdeen;   NHS Grampian
Not yet recruiting

Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study

Conditions:   Stroke;   Diabetes Mellitus;   Heart Disease;   Cancer
Intervention:  
Sponsors:   National Cancer Institute (NCI);   National Institute for Health and Welfare, Finland
Completed

NMT for Parkinson's Disease

Condition:   Parkinson Disease
Interventions:   Other: Neurologic Music Therapy;   Other: Occupational Therapy;   Other: Music Supported Therapy
Sponsors:   University of Colorado, Denver;   National Center for Complementary and Integrative Health (NCCIH)
Recruiting

Mood and Insulin Resistance in Adolescents At-Risk for Diabetes

Conditions:   Depression;   Impaired Glucose Tolerance
Interventions:   Other: The Blues Program;   Other: Hey Durham
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   National Institutes of Health Clinical Center (CC)
Completed

aMAZE Study: LAA Ligation Adjunctive to PVI for Persistent or Longstanding Persistent Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Device: LARIAT + PVI;   Device: Pulmonary Vein Isolation
Sponsor:   AtriCure, Inc.
Recruiting

Top-Down Attentional Control of Visual-Processing

Conditions:   Focal Brain Lesion;   Focal Lesions;   fMRI
Intervention:  
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting

Efficacy and Safety of Direct Oral Anticoagulants for the Treatment of Mural Thrombus

Condition:   Acute Myocardial Infarction
Intervention:  
Sponsor:   Methodist Health System
Not yet recruiting

Insulin Resistance and Atherosclerosis in Women With Lupus

Conditions:   Systemic Lupus Erythematosus;   Insulin Resistance;   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Completed

RHEIA (Randomized researcH in womEn All Comers With Aortic Stenosis)

Conditions:   Aortic Valve Stenosis;   Heart Valve Diseases
Intervention:   Device: Surgery
Sponsors:   SSS International Clinical Research GmbH;   Edwards Lifesciences
Not yet recruiting

Mobility Training to Improve Motor Behavior in Toddlers With or at Risk for Cerebral Palsy: A Pilot Study

Conditions:   Developmental Delay;   Cerebral Palsy
Intervention:   Behavioral: mobility training with dynamic body weight support
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed

Effect of Diet on Vascular Disease in Pre-Menopausal Women

Conditions:   Cardiovascular Diseases;   Vascular Disease;   Inflammation;   Insulin;   Triglycerides
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Effects of Rapid-Resisted Exercise and Bright Light Therapy on Ambulatory Adults With Traumatic Brain Injury

Conditions:   Adult;   Traumatic Brain Injury;   fMRI
Interventions:   Other: Exercise;   Other: Mood Therapy
Sponsors:   National Institutes of Health Clinical Center (CC);   Center for Neuroscience and Regenerative Medicine (CNRM);   Henry M. Jackson Foundation for the Advancement of Military Medicine;   United States Department of Defense
Completed

Apogee International

Condition:   Chronic Heart Failure
Intervention:   Device: HeartWare Ventricular Assist Device
Sponsor:   Medtronic Cardiac Rhythm and Heart Failure
Recruiting

Transcatheter Aortic Valve Replacement With Extracorporeal Life System Support

Conditions:   Aortic Stenosis;   Aortic Regurgitation;   Heart Failure With Reduced Ejection Fraction
Intervention:   Procedure: transcatheter aortic valve replacement
Sponsor:   Xijing Hospital
Recruiting

Anticoagulation on Demand in Paroxysmal Atrial Fibrillation After Percutaneous Coronary Intervention

Conditions:   Ischemic Heart Disease;   Atrial Fibrillation
Interventions:   Drug: Intermittent administration of dabigatran, rivaroxaban, apixaban, or edoxaban;   Drug: Chronic administration of dabigatran, rivaroxaban, apixaban, or edoxaban
Sponsor:   University of Roma La Sapienza
Not yet recruiting

Multi-Ethnic Study of Atherosclerosis (MESA)

Conditions:   Atherosclerosis;   Cardiovascular Diseases;   Heart Diseases;   Coronary Artery Disease;   Coronary Disease;   Stroke;   Myocardial Infarction;   Heart Failure;   Diabetes Mellitus, Type 2;   Hypertension;   Diabetes Mellitus
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain

Conditions:   Chronic Pain;   Post Stroke Pain;   Phantom Limb Pain;   Spinal Cord Injuries
Intervention:   Device: Medtronic Activa PC+S
Sponsors:   University of California, San Francisco;   United States Department of Defense
Recruiting

Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients

Conditions:   Frail Elderly;   Coronary Artery Disease
Interventions:   Procedure: Off-pump coronary-artery bypass grafting;   Procedure: On-pump coronary-artery bypass grafting
Sponsors:   University of Sao Paulo General Hospital;   Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina de São Paulo;   Hospital Alberto Urquiza Wanderley;   Hospital das Clínicas Samuel Libânio;   Hospital Samaritano Paulista;   Beneficência Portuguesa de São Paulo;   Hospital Samaritano Campinas;   Instituto Nacional de Cardiologia de Laranjeiras;   Pronto-Socorro Cardiológico Universitário de Pernambuco;   Mount Sinai Hospital, New York
Recruiting

Clinical Study for Workflow and Performance Evaluation of the THERMOCOOL SMARTTOUCH® SF-5D System for Treating Symptomatic Paroxysmal AF (QDOT-Micro)

Condition:   Atrial Fibrillation
Intervention:   Device: THERMOCOOL SMARTTOUCH® SF-5D catheter
Sponsor:   Biosense Webster, Inc.
Completed

Comparative Effectiveness of Empagliflozin in the US

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Empagliflozin;   Drug: DPP-4 inhibitor
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting

Hydroxychloroquine for Thrombosis Prevention and Antiphospholipid Antibody Reduction in Primary Antiphospholipid Syndrome

Condition:   Antiphospholipid Syndrome
Intervention:   Drug: Hydroxychloroquine
Sponsor:   National and Kapodistrian University of Athens
Completed

Brain Imaging for HIV-Associated Thinking and Mood Disorders

Conditions:   Human Immunodeficiency Virus;   Neurocognitive Impairment
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Allergy and Infectious Diseases (NIAID)
Terminated

A Study to Observe the Effectiveness of Empagliflozin, Other SGLT-2 Inhibitors, or DPP-4 Inhibitors in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Subjects treated with Empagliflozin or any Sodium-glucose cotransporter-2 (SGLT-2) inhibitor;   Drug: Subjects treated with Dipeptidyl peptidase-4 (DPP-4) inhibitor
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Clinical Study for Safety and Acute Performance Evaluation of the THERMOCOOL SMARTTOUCH® SF-5D System Used With Fast Ablation Mode in Treatment of Patients With Paroxysmal Atrial Fibrillation.

Condition:   Paroxysmal Atrial Fibrillation
Intervention:   Device: THERMOCOOL SMARTTOUCH SF-5D Catheter
Sponsor:   Biosense Webster, Inc.
Completed

A Study of MK-0822 in Postmenopausal Women With Osteoporosis to Assess Fracture Risk (MK-0822-018)

Condition:   Postmenopausal Osteoporosis
Interventions:   Drug: Odanacatib;   Drug: Placebo for Odanacatib;   Dietary Supplement: Vitamin D3;   Dietary Supplement: Calcium carbonate
Sponsor:   Merck Sharp & Dohme Corp.
Terminated

Clopidogrel Aspirin Therapy (CAT) Versus Apixiban Aspirin Therapy (AAT) After Lower Limb Revascularization

Conditions:   Ischemia;   Anticoagulants
Intervention:   Drug: Combination drug
Sponsor:   Mansoura University
Recruiting

Allogeneic Human Mesenchymal Stem Cell Infusion Versus Placebo in Patients With Alzheimer's Disease

Condition:   Alzheimer's Disease
Interventions:   Biological: Longeveron Mesenchymal Stem Cells;   Biological: Placebo
Sponsor:   Longeveron LLC
Active, not recruiting

Cost-effectiveness and Safety of the CADScorSystem in Patients With Symptoms Suggestive of Stable Coronary Artery Disease.

Condition:   Angina, Stable
Intervention:   Device: CADScor®System
Sponsors:   Bispebjerg Hospital;   Region Hovedstaden;   Larix A/S;   Acarix;   Kai Hansens Fond;   Kai Houmann Nielsens Fond
Recruiting

Prospective/Retrospective Registry of the E-vita OPEN PLUS Stent Graft System in France

Condition:   Vascular Diseases
Intervention:   Device: Surgical repair
Sponsor:   JOTEC GmbH
Active, not recruiting

A Study of People With Type 2 Diabetes Who Have Diseases That Affect the Heart and Blood Vessels. The Study Will Also Look at the Treatment of a Group of These People in Hospitals in Portugal

Condition:   Diabetes Mellitus, Type 2
Intervention:   Other: No treatment given
Sponsor:   Novo Nordisk A/S
Completed

MEMENTO-VAScular COmponents of Dementia

Conditions:   Alzheimer's Disease (AD);   Alzheimer's Disease (AD) Related Disorders
Intervention:   Other: in Memento-VASCOD
Sponsors:   University Hospital, Bordeaux;   Ministry for Health and Solidarity, France
Active, not recruiting

Cardiometabolic Risk Factors Registry

Conditions:   Atherosclerosis;   Metabolic Syndrome;   Diabetes;   Cardiovascular Risk Factor;   Cardiovascular Diseases;   Obesity
Intervention:  
Sponsor:   Austral University, Argentina
Recruiting

A Study Based on Data From German Registries That Looks at Characteristics of People Who Take the Medicine Empagliflozin for Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Intervention:   Drug: Empagliflozin
Sponsor:   Boehringer Ingelheim
Active, not recruiting

MOSTEGRA TRIAL:MO-(Dified) STE-(nt) GRA(-ft): Surgeon-modified Fenestrated-branched Stent-grafts

Condition:   Complex Aortic Aneurysms
Intervention:   Device: surgeon-modified fenestrated-branched stent-grafts (sm-FBSG)
Sponsor:   Northside Hospital, Inc.
Terminated

Prospective Descriptive Study of the Angiogenic T Cell Population in Subjects With Hereditary Hemorrhagic Telangiectasia (HHT)

Condition:   Hereditary Hemorrhagic Telangiectasia
Interventions:   Biological: Blood samples;   Other: Epistaxis charts
Sponsor:   Centre Hospitalier Universitaire Dijon
Recruiting

Motivational Interviewing to Support Oral AntiCoagulation Adherence in Patients With Non-valvular Atrial Fibrillation (MISOAC-AF)

Conditions:   Patient Compliance;   Patient Adherence
Interventions:   Behavioral: Motivational interview;   Behavioral: Control
Sponsor:   AHEPA University Hospital
Completed

EVAS2 IDE Prospective, Multicenter, Single Arm Safety and Effectiveness Confirmatory Study

Condition:   Abdominal Aortic Aneurysm Without Rupture
Intervention:   Device: Nellix® System
Sponsor:   Endologix
Recruiting

Evaluation of a Cardiovascular Active Prevention in Chronic Myeloid Leukemia on the Cardiovascular Morbi-mortality

Condition:   Chronic Myeloid Leukemia (CML)
Interventions:   Combination Product: Optimal medical treatment;   Combination Product: usual clinical practice
Sponsor:   University Hospital, Angers
Not yet recruiting

Ventricular Stimulation as Predictor of Hypovolemia After Cardiac Surgery

Conditions:   Cardiac Surgery;   Hypovolemia
Intervention:   Diagnostic Test: Detection of hypovolemia using a ventricular stimulation without atrial pacing
Sponsor:   CMC Ambroise Paré
Recruiting

Comparison Three vs Twelve Months of Dual Anti-Platelet Therapy After Stent Implantation

Conditions:   Drug-Eluting Stents;   Percutaneous Coronary Intervention
Interventions:   Drug: 3 months DAPT;   Drug: 12 months DAPT
Sponsor:   Shanghai MicroPort Medical (Group) Co., Ltd.
Recruiting

Early Feasibility Study of the Cardiovalve System for Tricuspid Regurgitation

Condition:   Tricuspid Regurgitation
Intervention:   Device: Cardiovalve Transfemoral Tricuspid Valve
Sponsors:   Boston Biomedical Associates;   Cardiovalve Ltd.;   Cardiovascular Research Foundation, New York
Not yet recruiting

PROTein to Enhance outComes of (Pre)Frail paTients Undergoing Cardiac Surgery

Conditions:   Frail Older Adult Syndrome;   Nutrition Poor;   Cardiovascular Morbidity
Interventions:   Dietary Supplement: ISOlution protein supplement;   Dietary Supplement: Placebo Supplement
Sponsors:   St. Boniface General Hospital Research Centre;   Heart and Stroke Foundation of Canada
Not yet recruiting

Platelet Reactivity in PAD Undergoing Percutaneous Angioplasty

Conditions:   Peripheral Artery Disease;   Critical Limb Ischemia;   Claudication, Intermittent
Intervention:   Drug: Aspirin 300mg and Clopidogrel 300mg
Sponsor:   Clinical Centre of Serbia
Not yet recruiting

A Study of Efepoetin Alfa in Treating Anaemia Associated With Chronic Kidney Diseases Patient

Condition:   Anaemia Associated With Chronic Kidney Disease
Interventions:   Drug: efepoetin alfa;   Drug: Mircera
Sponsors:   PT Kalbe Genexine Biologics;   Novotech (Australia) Pty Limited
Not yet recruiting

Ablation of Ventricular Fibrillation by Accurate Targeting of Arrhythmogenic Regions (AVATAR)

Condition:   Ventricular Tachyarrhythmias
Intervention:  
Sponsor:   University of California, San Diego
Completed

Optimizing PTCy Dose and Timing

Conditions:   Graft Versus Host Disease;   Hematologic Neoplasms
Interventions:   Drug: Busulfan;   Drug: Fludarabine;   Drug: Cyclophosphamide;   Drug: Mycophenolate Mofetil;   Drug: Sirolimus
Sponsors:   National Cancer Institute (NCI);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Aggressive Antipyretics for Fever Reduction in CNS Malaria

Conditions:   Malaria;   Seizures;   Coma;   Parasitemia;   Hyperpyrexia
Interventions:   Drug: Acetaminophen;   Drug: Ibuprofen;   Drug: placebo for acetaminophen;   Drug: placebo for ibuprofen
Sponsors:   University of Rochester;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

AFQ056 for Language Learning in Children With FXS

Condition:   Fragile X Syndrome
Interventions:   Drug: AFQ056;   Other: Placebo;   Other: Language Intervention
Sponsors:   Elizabeth Berry-Kravis;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Human Mesenchymal Stem Cells (LMSCs) on Vaccine-Specific Antibody- Response in Subjects With Aging Frailty

Condition:   Aging Frailty
Interventions:   Biological: Longeveron Mesenchymal Stem Cells (LMSCs);   Biological: Fluzone High Dose Vaccine
Sponsor:   Longeveron LLC
Recruiting

Women's Heart Attack Research Program: Stress Ancillary Study

Condition:   Myocardial Infarction
Interventions:   Behavioral: Enhanced Usual Care;   Behavioral: Stress Management;   Diagnostic Test: Actigraph
Sponsor:   NYU Langone Health
Recruiting

China Extracorporeal Life Support Registry

Conditions:   Cardiogenic Shock;   Cardiac Arrest;   Heart Failure;   Acute Respiratory Distress Syndrome;   Acute Respiratory Failure
Intervention:   Device: ECMO
Sponsor:   Beijing Anzhen Hospital
Recruiting

Cost-utility Analysis of the Follow-up of Exclusive Telemedicine Pacemakers, Compared to Conventional Pacemakers

Conditions:   Single or Dual Chamber Pacemaker Implantation;   Home Monitoring Follow-up
Interventions:   Other: Follow up post Pacemaker implantation in office;   Other: Follow up post Pacemaker implantation by home monitoring
Sponsors:   Nantes University Hospital;   Tours University Hospital;   Marseille University Hospital;   Rennes University Hospital;   Toulouse University Hospital;   University Hospital, Clermont-Ferrand;   Angers University Hospital;   Lille University Hospital;   Strasbourg University Hospital;   Rouen University Hospital;   Montpellier University Hospital;   University Hospital, Brest;   Pau University Hospital
Recruiting

Myotonic Dystrophy and Facioscapulohumeral Muscular Dystrophy Registry

Conditions:   Myotonic Dystrophy;   Facioscapulohumeral Muscular Dystrophy;   Muscular Dystrophy;   Myotonic Dystrophy Type 1;   Myotonic Dystrophy Type 2;   Congenital Myotonic Dystrophy;   PROMM (Proximal Myotonic Myopathy);   Steinert's Disease;   Myotonic Muscular Dystrophy
Intervention:  
Sponsors:   University of Rochester;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

RESPOND Post Market Study

Condition:   Aortic Valve Stenosis
Intervention:   Device: Lotus Valve System
Sponsor:   Boston Scientific Corporation
Active, not recruiting

CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of AKCEA-TTR-LRx in Participants With Transthyretin‑Mediated Amyloid Cardiomyopathy (ATTR CM)

Condition:   Transthyretin‑Mediated Amyloid Cardiomyopathy (ATTR CM)
Interventions:   Drug: AKCEA-TTR-LRx;   Drug: Placebo
Sponsors:   Ionis Pharmaceuticals, Inc.;   Akcea Therapeutics
Not yet recruiting

Study to Gather Information to What Extent Patients Follow the Treatment Regimen of Low-dose Aspirin for Primary and Secondary Prevention of Diseases of the Heart and Blood Vessels

Conditions:   Myocardial Infarction;   Stroke (Including Ischaemic Stroke and Transient Ischaemic Attack);   Unstable Angina;   Angina;   Ischaemic Heart Disease
Intervention:   Drug: Acetylsalicylic Acid (Aspirin, BAYE4465)
Sponsor:   Bayer
Active, not recruiting

Assessment of Myocardial Ischemic-Reperfusion Injury During Off- and On- Pump CABG

Conditions:   Ischemic Heart Disease;   Coronary Artery Disease;   Ischemic Reperfusion Injury;   CABG
Interventions:   Procedure: On-Pump CABG.;   Procedure: Off-Pump CABG.;   Procedure: BH-CABG MSC.
Sponsor:   St. Petersburg State Pavlov Medical University
Completed

Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion

Conditions:   Sepsis;   Cardiomyopathies;   Hypoperfusion;   Left Ventricular Systolic Dysfunction
Interventions:   Drug: Placebos;   Drug: Dobutamine
Sponsors:   University Hospital, Limoges;   Centre d’Investigation Clinique 1415
Not yet recruiting

Henan STEMI Registry

Condition:   ST-segment Elevation Myocardial Infarction
Intervention:  
Sponsor:   Henan Institute of Cardiovascular Epidemiology
Completed

Prediction of Brain Injury in Premature Infants

Conditions:   Intraventricular Hemorrhage;   Periventricular Leukomalacia;   Brain Injury;   Extreme Prematurity
Intervention:   Other: Brain Monitoring Platform
Sponsors:   Baylor College of Medicine;   Texas Children's Hospital;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Study to Gain Insights in Treatment Patterns and Outcomes in Patients With Atherosclerosis Prescribed to Xarelto in Combination With Acetylsalicylic Acid

Condition:   Atherosclerosis
Interventions:   Drug: Rivaroxaban (BAY59-7939, Xarelto);   Drug: Acetylsalicylic acid
Sponsors:   Bayer;   Janssen, LP
Recruiting

Chronic Hypertension and Pregnancy (CHAP) Project

Condition:   Hypertension
Interventions:   Drug: Anti-hypertensive therapy;   Other: No anti-hypertensive therapy (unless BP is severe)
Sponsors:   University of Alabama at Birmingham;   Columbia University;   Drexel University College of Medicine;   Rutgers, The State University of New Jersey;   Lehigh Valley Hospital;   Saint Peters University Hospital;   Christiana Care Health Services;   Washington University School of Medicine;   Duke University;   University of Texas Southwestern Medical Center;   The University of Texas Health Science Center, Houston;   Stanford University;   University of Pennsylvania;   The University of Texas Medical Branch, Galveston;   University of Utah;   Intermountain Health Care, Inc.;   University of California, San Francisco;   Johns Hopkins University;   University of Pittsburgh;   Ochsner Health System;   University of North Carolina, Chapel Hill;   National Heart, Lung, and Blood Institute (NHLBI);   WakeMed Health and Hospitals;   San Francisco General Hospital;   McKay-Dee Hospital;   Winthrop University Hospital;   New York Hospital Queens;   Latter Day Saints Hospital;   Lyndon B Johnson General Hospital;   Virtua Medical Group;   Bayview Medical Center;   Duke Regional Hospital;   Utah Valley Regional Medical Center;   Northwestern;   Brown (WIHRI);   Baylor College of Medicine;   Case Western/Metro Health;   Ohio State University;   University of Iowa;   University of California, San Diego;   Indiana University;   Unity Point Health-Meriter Hospital WI;   Weill Medical College of Cornell University;   University of Oklahoma;   Medical University of South Carolina;   Beaumont Hospital;   University of Colorado, Denver;   University of Kansas Medical Center;   Denver Health and Hospital Authority;   Gundersen Health System;   Aurora Health Care;   Oregon Health and Science University;   Medical College of Wisconsin;   Temple University;   New Jersey Medical School;   University of South Alabama;   Vanderbilt University;   University of Arkansas;   Miami Valley Hospital;   Emory University;   St. Luke's Hospital and Health Network, Pennsylvania;   Cleveland Clinic Fairview Hospital;   University of Tennessee Health Science Center;   TriHealth Inc.;   Cleveland Clinic Hillcrest Hospital;   Tulane University;   Yale University;   Arrowhead Regional Medical Center;   Geisinger Clinic
Recruiting

Rivaroxaban for the Prevention of Deep Vein Thrombosis in Patients With Left Iliac Vein Compression - The PLICTS Study

Condition:   May-Thurner Syndrome
Interventions:   Drug: Rivaroxaban;   Drug: Warfarin;   Drug: Nadroparin
Sponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Sir Run Run Shaw Hospital;   Huadong Hospital;   Shanghai Zhongshan Hospital;   Shanghai 5th People's Hospital;   Yantai Yuhuangding Hospital;   Anhui Provincial Hospital
Not yet recruiting

The RISE Trial: A Randomized Trial on Intra-Saccular Endobridge Devices

Conditions:   Intracranial Aneurysm;   Brain Aneurysm;   Unruptured Cerebral Aneurysm;   Ruptured Cerebral Aneurysm;   Cerebral Aneurysm
Interventions:   Procedure: surgical clipping, simple coiling, high-porosity stenting with/ without coiling, intra-arterial flow diversion with/ without coiling;   Device: WEB embolization device
Sponsor:   Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting

Rivaroxaban and Vitamin K Antagonists for the Anticoagulation for the Implantation of Vena Cava Filters

Condition:   Venous Thromboembolism
Interventions:   Drug: Rivaroxaban;   Drug: Warfarin;   Drug: Nadroparin
Sponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Sir Run Run Shaw Hospital;   Huadong Hospital;   Shanghai Zhongshan Hospital;   Shanghai 5th People's Hospital;   Yantai Yuhuangding Hospital;   Anhui Provincial Hospital
Not yet recruiting

Controlled MAP Trauma Brain Injury (COMAT Study)

Condition:   Traumatic Brain Injury
Intervention:   Device: EV1000 and closed-loop system
Sponsors:   Assistance Publique - Hôpitaux de Paris;   University of California, Los Angeles;   University of California, Irvine
Recruiting

Arts & Health Education to Improve Health, Resilience, and Well-Being

Conditions:   Hypertension;   Diabetes;   Obesity;   COPD;   CHF;   High Cholesterol;   Asthma;   Chronic Pain;   Multiple Sclerosis;   Depression;   Anxiety;   Heart Diseases;   Stroke
Interventions:   Behavioral: HeRe We Arts;   Behavioral: HeRe We Ed
Sponsors:   The Cleveland Clinic;   National Endowment for the Arts;   Cuyahoga Arts and Culture
Recruiting

Functional Exercise and Nutrition Education Program for Older Adults

Conditions:   Chronic Disease;   Frail;   Diabetes Mellitus;   Cancer;   Chronic Lung Disease;   Cardiovascular Diseases;   Congestive Heart Failure;   Hypertension;   Osteoporosis, Osteopenia;   Arthritis;   Stroke;   Kidney Diseases
Interventions:   Other: Strength and Balance Training & Nutrition Education;   Other: Usual Care
Sponsors:   University of Waterloo;   Canadian Institutes of Health Research (CIHR);   City of Lakes family Health Team;   Schlegel Villages and Research Institute for Aging;   YMCA;   Kinnect to Wellness
Active, not recruiting

Left Bundle Area Versus Selective His Bundle Pacing

Conditions:   Bradycardia;   Sinus Node Dysfunction;   Atrioventricular Block
Intervention:   Device: Select Secure pacing lead
Sponsor:   David Haines, MD
Recruiting

Comparison of Aortic Stenosis Subtypes After Balloon Aortic Valvuloplasty

Condition:   Aortic Valve Stenosis
Interventions:   Procedure: BAV;   Procedure: BAV + TAVR
Sponsor:   Heinrich-Heine University, Duesseldorf
Completed

Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

Conditions:   Spinal Cord Injuries;   Nerve Injury;   Pain, Postoperative;   Post Herpetic Neuralgia;   Complex Regional Pain Syndromes;   Post-Stroke Pain;   Post Radiation Brain Injury;   Post Radiation Plexopathy;   Nerve Root Avulsion
Intervention:   Device: Medtronic Summit RC+S
Sponsor:   University of California, San Francisco
Recruiting

Periinterventional Outcome Study in the Elderly

Conditions:   Mortality;   Complication, Postoperative
Intervention:   Procedure: Surgical or non-surgical intervention
Sponsor:   Mark Coburn
Completed

ACURATE NEO/TF Transcatheter Heart Valves and Non-inferiority Versus Medtronic CoreValve Systems

Condition:   Aortic Stenosis
Interventions:   Device: Transcatheter Aortic Valve Implantation with ACURATE NEO/TF;   Device: Transcatheter Aortic Valve Implantation with Medtronic Evolut R/Pro
Sponsors:   National and Kapodistrian University of Athens;   Naval Hospital, Athens;   Silesian Centre for Heart Diseases;   Henry Dunant Hospital, Athens;   University General Hospital of Heraklion
Recruiting

Multi-limb Dual-task Control in Parkinson's Disease

Condition:   Parkinson Disease
Intervention:   Other: multilimb dual task
Sponsors:   A.T. Still University of Health Sciences;   National Institute of Neurological Disorders and Stroke (NINDS);   University of Idaho;   Mayo Clinic
Recruiting

A Pilot Study of Vitamin D in Boys With X-linked Adrenoleukodystrophy

Condition:   X-linked Adrenoleukodystrophy
Intervention:   Dietary Supplement: vitamin D3
Sponsors:   Stanford University;   National Institute of Neurological Disorders and Stroke (NINDS);   Hugo W. Moser Research Institute at Kennedy Krieger, Inc.;   ALD Connect, Inc.
Active, not recruiting

DBS for TRD With the Medtronic Summit RC+S

Conditions:   Major Depressive Disorder;   Treatment Resistant Depression
Intervention:   Device: Medtronic Summit RC+S DBS system
Sponsors:   Helen Mayberg;   Emory University;   Georgia Institute of Technology;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Transforming Research and Clinical Knowledge in Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Interventions:   Behavioral: In-Person Outcome Assessment;   Behavioral: Phone Outcome Assessment;   Procedure: 3T Magnetic Resonance Imaging (MRI);   Procedure: Blood Draw for Plasma, DNA, Serum, RNA
Sponsors:   University of California, San Francisco;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   Department of Health and Human Services
Enrolling by invitation

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Transvenous Approach for the Treatment of Cerebral Arteriovenous Malformations

Conditions:   Arteriovenous Malformations, Cerebral;   Unruptured Brain Arteriovenous Malformation;   Ruptured Brain Arteriovenous Malformation
Interventions:   Procedure: Standard Trans-Arterial Embolization (TAE);   Procedure: Trans-Venous Embolization (TVE)
Sponsor:   Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting

Early rhBNP on Myocardial Work in Patients With STEMI

Condition:   ST-Segment Elevated Myocardial Infarction
Interventions:   Drug: rhBNP;   Drug: Control
Sponsor:   RenJi Hospital
Not yet recruiting

The Footwork Step Technique in Flamenco Dancing

Conditions:   Kinesics;   Kinematics;   Injuries
Intervention:  
Sponsor:   Telethusa Centre for Flamenco Research
Completed

Women's Heart Attack Research Program- Imaging Study

Condition:   Myocardial Infarction
Interventions:   Device: OCT;   Other: CMR
Sponsor:   NYU Langone Health
Recruiting

Impact of Short-course Colchicine Versus Placebo After Pulmonary Vein Isolation (IMPROVE-PVI Pilot)

Conditions:   Atrial Fibrillation;   Recurrence
Interventions:   Drug: Colchicine 0.6 mg;   Drug: Matching placebo
Sponsor:   Population Health Research Institute
Not yet recruiting

Health Economics Evaluation of Catheter Ablation Versus Drug Therapy in Atrial Fibrillation (AF) in China

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Johnson & Johnson Medical, China
Completed

Evaluation of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Participants With Diabetic Nephropathy

Conditions:   Diabetes Mellitus, Type 2;   Diabetic Nephropathy
Interventions:   Drug: Canagliflozin;   Drug: Placebo
Sponsors:   Janssen Research & Development, LLC;   The George Institute for Global Health, Australia
Completed

TherApy in stabLe Coronary Artery dIsease Patients According to Clinical GuideliNes (ALIGN)

Condition:   Stable Ischemic Heart Disease
Intervention:   Behavioral: Patients with documented IHD
Sponsor:   National Research Center for Preventive Medicine
Active, not recruiting

Contrast-associated Acute Kidney Injury in Patients With Different Types of Coronary Artery Disease

Conditions:   Coronary Artery Disease;   Angina, Unstable;   Angina, Stable;   STEMI - ST Elevation Myocardial Infarction;   NSTEMI - Non-ST Segment Elevation MI;   Contrast-induced Nephropathy;   Acute Kidney Injury
Intervention:   Other: Iodinated contrast
Sponsor:   I.M. Sechenov First Moscow State Medical University
Not yet recruiting

Phenotype, Genotype & Biomarkers in ALS and Related Disorders

Conditions:   Amyotrophic Lateral Sclerosis;   Frontotemporal Dementia;   Primary Lateral Sclerosis;   Hereditary Spastic Paraplegia;   Progressive Muscular Atrophy;   Multisystem Proteinopathy
Intervention:  
Sponsors:   University of Miami;   National Institute of Neurological Disorders and Stroke (NINDS);   National Center for Advancing Translational Science (NCATS);   St. Jude Children's Research Hospital;   ALS Association
Recruiting

Performance Diagnosis of a Patent Foramen Ovale During Lung Transplantation Using Transesophageal Echocardiography

Condition:   Lung Transplant; Complications
Intervention:   Diagnostic Test: search for a patent foramen ovale
Sponsor:   Hopital Foch
Recruiting

Clinical Procedures to Support Research

Conditions:   Amyotrophic Lateral Sclerosis;   ALS-Frontotemporal Dementia;   Primary Lateral Sclerosis;   Progressive Muscular Atrophy
Intervention:  
Sponsors:   University of Miami;   Muscular Dystrophy Association;   National Institute of Neurological Disorders and Stroke (NINDS);   National Center for Advancing Translational Science (NCATS);   National Institutes of Health (NIH)
Recruiting

SPYRAL HTN-ON MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Recruiting

Trial of Andexanet in ICH Patients Receiving an Oral FXa Inhibitor

Condition:   Acute Intracranial Hemorrhage
Intervention:   Drug: andexanet alfa
Sponsors:   Portola Pharmaceuticals;   Population Health Research Institute
Recruiting

Trends in the Epidemiology and Treatment of Atopic Dermatitis in the United Kingdom (UK)

Conditions:   Atopic Dermatitis Eczema;   Atopic Dermatitis;   Eczema
Intervention:   Other: No intervention
Sponsors:   Momentum Data;   Pfizer;   Royal College of General Practitioners Research and Surveillance Centre
Active, not recruiting

CONTINuous Infra-Inguinal Stenting Using the Bard® LifeStent® VascUlar Stent SysteMs ("CONTINUUM")

Condition:   Superficial Femoral Artery Stenosis
Intervention:   Device: PTA followed by placement of LifeStent® Vascular Stent
Sponsor:   C. R. Bard
Terminated

Anemia Studies in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat in Non-Dialysis Subjects Evaluating Hemoglobin (Hgb) and Quality of Life (ASCEND-NHQ)

Condition:   Anaemia
Interventions:   Drug: Daprodustat (GSK1278863);   Drug: Placebo;   Drug: Iron therapy
Sponsor:   GlaxoSmithKline
Recruiting

The OCTOBER Trial - European Trial on Optical Coherence Tomography Optimized Bifurcation Event Reduction (OCTOBER)

Conditions:   Ischaemic Heart Disease;   Ischemic Heart Disease
Interventions:   Procedure: Angiographic guided PCI;   Procedure: OCT guided PCI
Sponsors:   Aarhus University Hospital Skejby;   Abbott
Recruiting

Percutaneous Needle Tenotomy (PNT) Versus Platelet Rich Plasma (PRP) With PNT in the Treatment of Chronic Tendinosis

Condition:   Chronic Tendinopathy
Interventions:   Procedure: PNT + PRP;   Procedure: PNT alone
Sponsor:   Hospital for Special Surgery, New York
Active, not recruiting

A Cohort of Outpatients From French Research Memory Centers in Order to Improve Knowledge on Alzheimer's Disease and Related Disorders

Condition:   Alzheimer's Disease (AD) and Related Disorders
Intervention:  
Sponsors:   University Hospital, Bordeaux;   Fondation Plan Alzheimer
Active, not recruiting

Longitudinal Study of Brain Amyloid imaGing in MEMENTO

Condition:   Alzheimer's Disease (AD) and Related Disorders
Interventions:   Drug: Flutemetamol (18F);   Drug: Florbetapir (18F)
Sponsors:   University Hospital, Bordeaux;   Fondation Plan Alzheimer;   GE Healthcare;   Avid Radiopharmaceuticals
Active, not recruiting

A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation

Conditions:   Persistent Atrial Fibrillation;   Atrial Fibrillation
Intervention:   Device: Radiofrequency Ablation
Sponsor:   EPIX Therapeutics
Recruiting

Mindfulness IN-home for Diabetes and Sleep Health

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Intervention:   Behavioral: Mindfulness-based stress reduction (MBSR) Intervention
Sponsors:   Emory University;   Georgia Center for Diabetes Translation Research;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

This Study Looks at the Effects of Idarucizumab in Patients Who Take Dabigatran and Need Emergency Surgery or Are Bleeding

Condition:   Atrial Fibrillation
Intervention:   Drug: Idarucizumab
Sponsor:   Boehringer Ingelheim
Recruiting

rTMS and Retraining in Focal Hand Dystonia

Condition:   Focal Dystonia
Interventions:   Device: Repetitive Transcranial Magnetic Stimulation;   Behavioral: Sensorimotor Retraining;   Behavioral: Non-specific Therapy
Sponsor:   University of Minnesota
Completed

Open-Label Extension and Safety Study for Patients With Crohn's Disease Previously Enrolled in the Etrolizumab Phase III Study GA29144

Condition:   Crohn Disease
Intervention:   Drug: etrolizumab
Sponsor:   Hoffmann-La Roche
Recruiting

A Study to Assess Whether Etrolizumab is a Safe and Effective Treatment for Participants With Moderately to Severely Active Crohn's Disease (CD)

Condition:   Crohn Disease
Interventions:   Drug: Etrolizumab;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Recruiting

CHANGE Neo™ TA Registry With ACURATE Neo™ Aortic Bioprosthesis and ACURATE Neo™ TA Transapical Delivery System

Condition:   Aortic Stenosis
Intervention:   Device: ACURATE neo™ Aortic Bioprosthesis
Sponsor:   Symetis SA
Recruiting

Comparing Early Versus Elective Colonoscopy

Condition:   Acute Lower Gastrointestinal Bleeding
Interventions:   Procedure: Early colonoscopy;   Procedure: Elective colonoscopy
Sponsor:   Tokyo University
Completed

A Dose-response Study of Tranexamic Acid in Total Hip Arthroplasty

Condition:   Arthropathy of Hip
Interventions:   Drug: Placebo;   Drug: Group 1: perfusion of 500 mg Exacyl;   Drug: Group 2: perfusion of 1000 mg Exacyl;   Drug: Group 3: perfusion of 1500 mg Exacyl;   Drug: Group 4: perfusion of 3000 mg Exacyl
Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
Not yet recruiting

Real-World Registry Assessing the Clinical Use of the Lutonix 035 Drug Coated Balloon Catheter

Conditions:   Peripheral Arterial Disease;   Peripheral Vascular Diseases;   Arterial Occlusive Diseases
Intervention:   Device: PTA (Lutonix® 035 DCB Catheter)
Sponsor:   C. R. Bard
Completed

The Case for Care of Persons With Dementia in Their Environments (COPE) in Programs of All-Inclusive Care of the Elderly) PACE Service Settings

Conditions:   Frontotemporal Dementia;   Dementia;   Multi-Infarct Dementia;   Vascular Dementia;   Mixed Dementia;   Alzheimer Disease;   Lewy Body Disease;   Pick Disease;   Neurocognitive Disorders
Intervention:   Behavioral: COPE online training
Sponsors:   University of Pennsylvania;   Drexel University;   Thomas Jefferson University;   Trinity Health System
Not yet recruiting

Pharmacokinetic, Pharmacodynamic, Safety, and Efficacy Study of Rivaroxaban for Thromboprophylaxis in Pediatric Participants 2 to 8 Years of Age After the Fontan Procedure

Condition:   Thrombosis
Interventions:   Drug: Rivaroxaban;   Drug: Acetylsalicylic Acid
Sponsors:   Janssen Research & Development, LLC;   Bayer
Active, not recruiting

Comparison of Optical Coherence Tomography-derived Minimal Lumen Area, Invasive Fractional Flow Reserve and FFRCT

Condition:   Coronary Stenosis
Intervention:   Diagnostic Test: OCT, FFR, CTA and FFRCT
Sponsor:   University Hospital Inselspital, Berne
Recruiting

Sildenafil in Heart Failure With Reactive Pulmonary Hypertension

Condition:   Heart Failure With Reactive Pulmonary Hypertension
Interventions:   Drug: Sildenafil;   Drug: Placebo
Sponsor:   Maya Guglin
Terminated

Non-Invasive Radiation Ablation in Patients With Hypertrophic CardioMyopathy: NIRA-HOCM

Condition:   Hypertrophic Cardiomyopathy
Intervention:   Device: Stereotactic body radiation therapy
Sponsors:   Barts & The London NHS Trust;   Barts Cardiovascular CTU (Queen Mary University of London);   Barts Charity
Not yet recruiting

Hypotension During Extracorporeal Circulatory Support Indicated for Cardiogenic Shock

Conditions:   Extracorporeal Life Support;   Hypotension;   Vasoplegia
Intervention:   Other: Arterial pressure management during circulatory support by VA-ECMO
Sponsor:   University Hospital, Montpellier
Recruiting

Thromboelastography (TEG) and Clopidogrel Withdrawal Time in Elderly Patients With Hip Fracture

Condition:   Hip Fracture
Intervention:   Procedure: Thrombelastograph and surgical timing
Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University
Not yet recruiting

Observational Study to Evaluate the BioMimics 3D Stent System: MIMICS-3D

Condition:   Peripheral Arterial Disease
Intervention:   Device: BioMimics 3D Stent
Sponsor:   Veryan Medical Ltd.
Active, not recruiting

FIRE AND ICE II Trial Pilot

Conditions:   Persistent Atrial Fibrillation;   Atrial Arrhythmia
Interventions:   Device: Cryoballoon (Arctic Front Advance Cryoballoon);   Device: Radiofrequency Catheter (ThermoCool Smarttouch)
Sponsors:   Medtronic Cardiac Rhythm and Heart Failure;   genae associates (CRO), Antwerp, Belgium;   King's College London;   Deutsches Herzzentrum Muenchen
Recruiting

Fast Track Pathway to Accelerated Cholecystectomy

Conditions:   Cholecystitis;   Cholecystectomy
Intervention:   Procedure: cholecystectomy
Sponsors:   P.J. Devereaux;   St. Joseph's Health Care London
Not yet recruiting

CARDSUP - SWISS Circulatory Support Registry

Condition:   Cardiogenic Shock
Intervention:  
Sponsor:   University Hospital Inselspital, Berne
Recruiting

VIRTUOSE : Efficiency of Sildenafil on the Absolute Claudication Distance of Peripheral Arterial Disease Patients With Intermittent Claudication.

Condition:   Peripheral Artery Disease
Interventions:   Drug: Sildenafil;   Drug: Placebo
Sponsor:   Rennes University Hospital
Not yet recruiting

The Current Health Status of Patients Living With Type 1 Diabetes From the LMC Diabetes Patient Registry

Condition:   Type1diabetes
Intervention:  
Sponsor:   LMC Diabetes & Endocrinology Ltd.
Not yet recruiting

Dabrafenib and Trametinib in Treating Patients With Erdheim Chester Disease With BRAF V600 Mutations

Condition:   Erdheim-Chester Disease
Interventions:   Drug: Dabrafenib Mesylate;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Drug: Trametinib Dimethyl Sulfoxide
Sponsor:   National Cancer Institute (NCI)
Not yet recruiting

Remifentanil and Glycemic Response in Cardiac Surgery

Conditions:   Heart Diseases;   Hyperglycemia
Interventions:   Drug: Remifentanil;   Drug: Fentanyl
Sponsors:   Kathirvel Subramaniam;   Mylan Inc.
Completed

Slow and Deep Breathing to Lower Blood Pressure in Women With Pregnancy-induced Hypertension

Condition:   Pregnancy-Induced Hypertension
Intervention:   Other: Slow and deep breathing
Sponsor:   Bournemouth University
Not yet recruiting

Pravastatin to Prevent Preeclampsia

Conditions:   Preeclampsia;   Obstetric Labor Complications;   Hypertension in Pregnancy
Interventions:   Drug: Pravastatin;   Other: Placebo
Sponsors:   The George Washington University Biostatistics Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Oral + Parenteral Antibiotic Prophylaxis in Colonic Surgery With Mechanical Bowel Preparation vs. no Mechanical Bowel Preparation.

Conditions:   Wounds and Injuries;   Surgery--Complications
Interventions:   Drug: Cefuroxime (750mg) I.V;   Procedure: Colorectal Surgery;   Drug: Cefuroxime 750mg oral;   Drug: MetroNIDAZOLE 250 MG Oral Tablet [Flagyl];   Drug: Metronidazole 1,5gr Intravenous;   Drug: Cefuroxime 1g Intravenous;   Drug: Sodium picosulfate, light magnesium oxide, citric acid anhydrous (15.08 g)
Sponsor:   Hospital Universitari Vall d'Hebron Research Institute
Not yet recruiting