Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Xanthine Oxidase Inhibition for Improvement of Long-term Outcomes Following Ischaemic Stroke and Transient Ischaemic Attack

Condition:   Ischaemic Stroke
Interventions:   Drug: Allopurinol;   Drug: Placebo
Sponsors:   NHS Greater Glasgow and Clyde;   University of Glasgow
Not yet recruiting - verified April 2014

Study of Stroke Volume Variation and Pleth Variability Index as Predictors of Fluid Responsiveness

Conditions:   Thyroidectomy;   Fluid Responsiveness
Intervention:   Other: HES 130/0.4 (VolulyteⓇ, Fresenius Kabi, Canada)
Sponsor:   Chung-Ang University Hospital
Recruiting - verified April 2014

Functional Neuroimage in Assessment of Post-stroke Aphasia

Conditions:   Stroke;   Aphasia
Intervention:   Device: rTMS
Sponsors:   Taipei Veterans General Hospital, Taiwan;   vghtpe user
Recruiting - verified April 2014

Mechanisms of Early Recurrence in Intracranial Atherosclerotic Disease

Condition:   Intracranial Vascular Disorders
Intervention:  
Sponsors:   University of Miami;   University of California, Los Angeles;   Northwestern University;   Emory University;   Baystate Medical Center
Not yet recruiting - verified April 2014

Pilot Investigation of Stem Cells in Stroke Phase II Efficacy

Conditions:   Ischaemic Stroke;   Cerebral Infarction;   Hemiparesis;   Arm Paralysis
Intervention:   Biological: CTX DP
Sponsor:   ReNeuron Limited
Not yet recruiting - verified April 2014

Effects of Flywheel Resistance Training on Cognitive Function in Stroke Patients

Condition:   Stroke
Intervention:   Other: Flywheel leg-press resistance exercise
Sponsors:   Karolinska Institutet;   Corporacion Parc Tauli
Recruiting - verified April 2014

Anticoagulation in AF Ablation and Effects on Neurocognitive Function

Conditions:   Atrial Fibrillation;   Cerebrothromboembolus;   Neurocognitive Function
Intervention:   Procedure: Atrial Fibrillation Ablation
Sponsor:   University of California, San Francisco
Not yet recruiting - verified April 2014

Multicenter, Prospective, Randomized, Controlled, Double-blind Trial on the Impact of Rosuvastatin on Subclinical Markers of Atherosclerosis in Patients With Primary Necrotizing Vasculitides

Condition:   ANCA-associated Primary Necrotizing Vasculitides
Interventions:   Drug: Rosuvastatin;   Drug: Placebo
Sponsor:   Assistance Publique - Hôpitaux de Paris
Not yet recruiting - verified April 2014

Can a Vocal Stimulus Provoke Spontaneous Breathing in an Ischemic Stroke Patient Dependent on Mechanical Ventilation?

Condition:   Patients Ventilated by Mechanical Ventilation With Ischemic Stroke
Intervention:  
Sponsor:   The Baruch Padeh Medical Center, Poriya
Not yet recruiting - verified April 2014

Carnitine for the Treatment of Atherosclerosis.

Condition:   Metabolic Syndrome
Interventions:   Dietary Supplement: L-carnitine capsules;   Dietary Supplement: Lactose capsules
Sponsors:   Queen's University;   Heart and Stroke Foundation of Canada
Not yet recruiting - verified April 2014

ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea.

Conditions:   Heart Failure;   Obstructive Sleep Apnea;   Central Sleep Apnea
Intervention:   Other: [C11]Acetate and HED PET
Sponsor:   University of Ottawa Heart Institute
Recruiting - verified April 2014

Feasibility of AmbulanCe-based Telemedicine (FACT) Study

Condition:   Acute Stroke
Intervention:  
Sponsor:   Universitair Ziekenhuis Brussel
Active, not recruiting - verified April 2014

Effects of Treadmill Gait Training With Loading in Individuals With Stroke

Conditions:   Stroke;   Gait Disorders, Neurologic
Interventions:   Other: Treadmill, ankle load;   Other: Treadmill
Sponsor:   Universidade Federal do Rio Grande do Norte
Recruiting - verified April 2014

Upper Limb Rehabilitation After Stroke Assisted With a Hybrid Electrical Stimulation (ES)-Robot System

Condition:   Stroke
Intervention:   Device: Electrical Stimulation; Rehabilitation Robot
Sponsor:   The Hong Kong Polytechnic University
Recruiting - verified April 2014

Deep Brain Stimulation Therapy in Movement Disorders

Conditions:   Parkinson's Disease;   Movement Disorders;   Deep Brain Stimulation;   Dystonia;   Essential Tremor
Intervention:   Other: Deep Brain Stimulation Management
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2014

A Self-efficacy Enhancing Stroke Self-management Program for Community-dwelling Stroke Survivors

Condition:   Stroke
Interventions:   Behavioral: Stroke self-management program;   Behavioral: Usual care
Sponsor:   Queensland University of Technology
Not yet recruiting - verified April 2014

Rivaroxaban for Antiphospholipid Antibody Syndrome

Condition:   Antiphospholipid Antibody Syndrome
Intervention:   Drug: Rivaroxaban
Sponsors:   St. Joseph's Healthcare Hamilton;   Heart and Stroke Foundation of Canada;   Bayer;   Hamilton Health Sciences Corporation;   Jewish General Hospital;   University of Alberta;   The Ottawa Hospital;   Queen Elizabeth II Health Sciences Centre
Not yet recruiting - verified April 2014

INTERACTION, Monitoring of Stroke Patients in Hospital and Home Environment

Condition:   Stroke
Intervention:  
Sponsors:   University of Zurich;   University of Twente;   University of Pisa;   Roessingh;   XSens technologies B.V.;   Smartex S.r.l.
Recruiting - verified April 2014

Comparison of Stroke Volume Variation-guided Normovolemic and Restrictive Fluid Management During Craniotomy: a Randomized Controlled Trial

Conditions:   Supratentorial Neoplasms;   Brain Tumor, Primary;   Craniotomy
Intervention:   Drug: Intravenous colloid bolus with Voluven
Sponsor:   National Taiwan University Hospital
Recruiting - verified April 2014

Human-Machine System for the H2 Lower Limb Exoskeleton

Conditions:   Stroke;   Hemiparesis
Interventions:   Behavioral: Robot-assisted training with the H2 lower limb powered exoskeleton;   Behavioral: Supervised motor practice
Sponsors:   University of Houston;   The University of Texas Health Science Center, Houston;   TIRR Memorial Hermann
Recruiting - verified April 2014

Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders

Conditions:   Amyotrophic Lateral Sclerosis (ALS);   Myasthenia Gravis;   Myopathies;   Stroke;   Parkinson's Disease
Intervention:  
Sponsor:   Beth Israel Deaconess Medical Center
Recruiting - verified April 2014

Short-term Dual Anti Platelet Therapy in Patients With ACS Treated With the COMBO Dual-therapy Stent

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Treatment 3 months DAPT;   Drug: Treatment 12 months DAPT
Sponsor:   Diagram B.V.
Not yet recruiting - verified April 2014

Efficacy and Safety of ICD Implantation in the Elderly

Conditions:   Cardiomyopathy;   Coronary Artery Disease;   Congestive Heart Failure;   Myocardial Infarction
Interventions:   Device: Implantable Cardioverter Defibrillator;   Other: Optimal standard of care
Sponsor:   Department of Veterans Affairs
Not yet recruiting - verified April 2014

Atherosclerosis in High Risk Population Groups: An Assessment by Magnetic Resonance Imaging

Condition:   Atherosclerosis
Intervention:   Drug: Rosuvastatin 20 mg, Aspirin 81 mg
Sponsor:   Emory University
Active, not recruiting - verified April 2014

Adolescent Master Protocol for Participants 18 Years of Age and Older (AMP Up)

Condition:   HIV/AIDS
Intervention:  
Sponsors:   Harvard School of Public Health;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute on Drug Abuse (NIDA);   National Institute of Allergy and Infectious Diseases (NIAID);   Office of AIDS Research;   National Institute of Mental Health (NIMH);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Deafness and Other Communication Disorders (NIDCD);   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Dental and Craniofacial Research (NIDCR);   National Institute on Alcohol Abuse and Alcoholism (NIAAA);   Tulane University School of Medicine
Recruiting - verified April 2014

Treatment of Brain AVMs (TOBAS) Study

Conditions:   Unruptured Brain Arteriovenous Malformation;   Ruptured Brain Arteriovenous Malformation;   Arteriovenous Malformations;   AVM;   BAVM
Interventions:   Procedure: Neurosurgery;   Radiation: Radiation therapy;   Procedure: Embolization
Sponsor:   Centre hospitalier de l'Université de Montréal (CHUM)
Not yet recruiting - verified April 2014

Rectus Femoris Tenotomy Versus Botulinum Toxin A for Stiff Knee Gait After Stroke

Conditions:   Stroke;   Spasticity
Interventions:   Procedure: Tenotomy of the proximal rectus femoris tendon;   Drug: Botulinum Toxin injection in the rectus femoris muscle
Sponsor:   University Hospital of Mont-Godinne
Recruiting - verified April 2014

Outcomes of Angiotensin Converting Enzyme Inhibitor Management Strategies Prior to Coronary Artery Bypass

Condition:   Coronary Artery Disease
Interventions:   Drug: ACE/ARB continuation;   Drug: ACE/ARB withdrawal
Sponsor:   University of Alberta
Recruiting - verified April 2014

Transforming Research and Clinical Knowledge in Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Interventions:   Behavioral: In-Person Outcome Assessment;   Behavioral: Phone Outcome Assessment;   Procedure: 3T Magnetic Resonance Imaging (MRI);   Procedure: Blood Draw for Plasma, DNA, Serum, RNA
Sponsors:   University of California, San Francisco;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   Department of Health and Human Services
Recruiting - verified April 2014

Elite Controller and ART-treated HIV+ Statin Versus ASA Treatment Intervention Study

Condition:   Immunodeficiency Virus, Human
Interventions:   Drug: Aspirin 81 mg table;   Drug: Atorvastatin 40 mg
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2013

A Study of the Efficacy and Safety of Activase (Alteplase) in Patients With Mild Stroke (PRISMS)

Condition:   Brain Ischemia
Interventions:   Drug: alteplase [Activase];   Drug: alteplase placebo;   Drug: aspirin;   Drug: aspirin placebo
Sponsor:   Genentech
Recruiting - verified April 2014

Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic VTE(Venous Thromboembolism)

Conditions:   Pulmonary Embolism;   Thromboembolism;   Thrombosis;   Venous Thrombosis;   Venous Thromboembolism
Interventions:   Drug: BAY 59-7939;   Drug: BAY 59-7939;   Drug: ASA
Sponsor:   Bayer
Recruiting - verified April 2014

BAY 59-7939 (Xarelto, SPAF), Non Interventional Studies

Condition:   Atrial Fibrillation
Interventions:   Drug: Phenprocoumon (Marcumar);   Drug: Rivaroxaban (Xarelto, BAY-59 7939)
Sponsor:   Bayer
Recruiting - verified April 2014

Mitochondrial nt3243 A>G Mutation in Taiwan

Conditions:   MELAS Syndrome;   Noninsulin-dependent Diabetes Mellitus With Deafness
Intervention:  
Sponsors:   National Taiwan University Hospital;   National Cheng-Kung University Hospital
Recruiting - verified April 2014

The Effects of Disease Management Programs for Prevention of Recurrent Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Other: disease management;   Other: usual care
Sponsors:   Hiroshima University;   Ministry of Health, Labour and Welfare, Japan
Active, not recruiting - verified April 2014

Post Market Surveillance Study of the Wingspan Stent System

Condition:   Intracranial Atherosclerosis
Intervention:   Device: Wingspan Stent System
Sponsor:   Stryker Neurovascular
Recruiting - verified April 2014

Open-Label, Dose-Escalating Study to Assess Safety, Tolerability, Efficacy, PK and PD of RP103 in Children With Inherited Mitochondrial Disease

Condition:   Inherited Mitochondrial Disease, Including Leigh Syndrome
Intervention:   Drug: Cysteamine Bitartrate Delayed-release Capsules (RP103)
Sponsor:   Raptor Pharmaceuticals Inc.
Recruiting - verified March 2014

A Trial to Evaluate a New Strategy in the Functional Assessment of 3-vessel Disease Using the SYNTAX II Score in Patients Treated With PCI

Conditions:   Heart Diseases;   Cardiovascular Diseases;   3 Vessel Coronary Artery Disease
Interventions:   Device: Coronary stent;   Radiation: Multi Slice Computed Tomography;   Device: instantaneous wave-free ratio;   Device: Fractional flow reserve;   Device: Intravascular Ultrasound
Sponsors:   ECRI bv;   Boston Scientific Corporation;   Volcano Corporation
Recruiting - verified April 2014

Efficacy and Safety of FTY720 for Acute Stroke

Conditions:   Stroke;   Vascular Accident;   Cerebral Stroke;   Ischemic Cerebrovascular Accident;   Stroke, Acute
Intervention:   Drug: Fingolimod
Sponsor:   Tianjin Medical University General Hospital
Recruiting - verified April 2014

Stroke Feasibility Study

Conditions:   Atrial Fibrillation;   AFib
Intervention:   Device: AtriClip LAA Exclusion Device
Sponsor:   AtriCure, Inc.
Recruiting - verified April 2014

A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Ticagrelor 90 mg;   Drug: Ticagrelor placebo
Sponsor:   AstraZeneca
Recruiting - verified April 2014

Cardiovascular Outcomes Following Treatment With Ertugliflozin in Participants With Type 2 Diabetes Mellitus and Established Vascular Disease (MK-8835-004)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Ertugliflozin;   Drug: Placebo
Sponsors:   Merck Sharp & Dohme Corp.;   Pfizer
Recruiting - verified April 2014

Cognitive Impairment Related to Atrial Fibrillation Prevention Trial

Condition:   Atrial Fibrillation
Interventions:   Drug: Warfarin;   Drug: Dabigatran
Sponsors:   University of Sao Paulo;   Federal University of Minas Gerais;   Boehringer Ingelheim
Not yet recruiting - verified April 2014

Adjunctive Everolimus (RAD 001) Therapy for Epilepsy in Children With Sturge-Weber Syndrome (SWS)

Condition:   Sturge Weber Syndrome
Intervention:   Drug: Everolimus
Sponsors:   Baylor College of Medicine;   Novartis Pharmaceuticals
Recruiting - verified April 2014

Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health in Spinal Cord Injury

Condition:   Spinal Cord Injury
Intervention:  
Sponsors:   James J. Peters Veterans Affairs Medical Center;   Kessler Foundation
Recruiting - verified April 2014

Hip Fracture Impact on Vascular Events In Noncardiac Surgery patIents: a cOhort evaluatioN (Hip VISION): Pilot Study

Condition:   Hip Fractures
Intervention:  
Sponsor:   Population Health Research Institute
Active, not recruiting - verified April 2014

Evaluating Human-Machine Interfaces in a Robotic Thumb Orthosis

Conditions:   Hemiplegic Stroke;   Hemiplegic Cerebral Palsy
Intervention:   Device: Isolated Orthosis for Thumb Actuation (IOTA)
Sponsors:   Wyss Institute at Harvard University;   Children's Hospital Boston;   Deborah Munroe Noonan Memorial Research Fund
Active, not recruiting - verified April 2014

Safety, Tolerability and Activity Study of Ibudilast in Subjects With Progressive Multiple Sclerosis

Conditions:   Multiple Sclerosis, Primary Progressive;   Multiple Sclerosis, Secondary Progressive
Interventions:   Drug: ibudilast;   Drug: Placebo
Sponsors:   MediciNova;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   National Multiple Sclerosis Society
Recruiting - verified April 2014

Visual Perceptual Learning for the Treatment of Visual Field Defect

Conditions:   Stroke;   Visual Field Defect
Intervention:   Behavioral: Visual perceptual learning
Sponsor:   Asan Medical Center
Recruiting - verified April 2014

A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Events

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: insulin degludec;   Drug: insulin glargine
Sponsor:   Novo Nordisk A/S
Recruiting - verified April 2014

Detection and Neurological Impact of CerebroVascular Events In Noncardiac Surgery PatIents: A COhort EvaluatioN

Condition:   Covert Postoperative Stroke
Intervention:  
Sponsors:   McMaster University;   Hamilton Health Sciences Corporation
Recruiting - verified April 2014

GLORIA-AF Registry Program (Phase II/III)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2014

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)

Condition:   Pulmonary Embolism
Interventions:   Drug: Rivaroxoban (Xarelto, Bay59-7939);   Drug: Acenocoumarol
Sponsor:   Bayer
Recruiting - verified April 2014

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)

Condition:   Pulmonary Embolism
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Warfarin
Sponsor:   Bayer
Recruiting - verified April 2014

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Germany)

Condition:   Pulmonary Embolism
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Phenprocoumon
Sponsor:   Bayer
Recruiting - verified April 2014

Identification of Admission High Risk Elderly

Conditions:   Pneumonia;   Urinary Tract Infection;   Stroke
Intervention:  
Sponsor:   National Taiwan University Hospital
Completed - verified April 2014

Non-interventional Local Study on Prescription Behavior of Anticoagulation Therapy in Secondary Stroke Prevention in Atrial Fibrillation Patients

Conditions:   Stroke,;   Embolism
Intervention:   Other: Rivaroxaban ( Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified April 2014

A Study of Movement Disorders Using the QMAT At-Home Testing Device

Conditions:   Movement Disorders;   Parkinson's Disease
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2014

CARMELINA: Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus at High Vascular Risk

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Placebo;   Drug: Linagliptin
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified April 2014

Cortical Recording and Stimulating Array Brain-Machine Interface

Conditions:   Tetraplegia;   Spinal Cord Injury;   Brainstem Stroke
Intervention:   Device: Implantation of CRS Arrays in the motor cortex and sensory cortex of the brain
Sponsors:   University of Pittsburgh;   Defense Advanced Research Projects Agency;   Department of Defense;   Johns Hopkins University
Recruiting - verified April 2014

Brain Machine Interface Control of an Robotic Exoskeleton in Training Upper Extremity Functions in Stroke

Conditions:   Stroke;   Hemiparesis
Intervention:   Device: MAHI EXO-II exoskeleton augmented with BMI system
Sponsors:   The University of Texas Health Science Center, Houston;   University of Houston;   The Methodist Hospital System;   National Institute of Neurological Disorders and Stroke (NINDS);   TIRR Memorial Hermann
Recruiting - verified April 2014

The Effects of Repetitive Paired Associative Stimulation in Dystonia

Condition:   Dystonia
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2014

Flow MRI in Normal Pressure Hydrocephalus

Condition:   Normal Pressure Hydrocephalus
Intervention:   Other: Flow imaging
Sponsor:   Centre Hospitalier Universitaire, Amiens
Recruiting - verified April 2014

Cerebrospinal Fluid Collection and Repository Storage

Condition:   Neurological Diseases
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2014

Study Of Diabetic Nephropathy With Atrasentan

Condition:   Diabetic Nephropathy
Interventions:   Drug: Atrasentan;   Drug: Placebo
Sponsor:   AbbVie
Recruiting - verified April 2014

Therapeutic Outcomes Using Contact Force Handling During Atrial Fibrillation Ablation

Condition:   Persistent Atrial Fibrillation
Intervention:   Device: ThermoCoolSmartTouch ablation catheter, Biosense Webster
Sponsors:   Southlake Regional Health Centre;   Applied Health Research Centre (AHRC)
Recruiting - verified April 2014

Exploring the Efficacy of Once Daily Oral Rivaroxaban for Treatment of Thrombus in Left Atrial/Left Atrial Appendage in Subjects With Nonvalvular Atrial Fibrillation or Atrial Flutter

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting - verified April 2014

Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III

Condition:   Intracerebral Hemorrhage
Intervention:   Drug: rt-PA
Sponsors:   Johns Hopkins University;   Daniel Hanley;   National Institute of Neurological Disorders and Stroke (NINDS);   Genentech;   Emissary International LLC
Recruiting - verified April 2014

The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome

Conditions:   Antiphospholipid Syndrome;   Endothelial Dysfunction;   Hyperuricemia;   Gout;   Metabolic Syndrome
Intervention:  
Sponsor:   National Taiwan University Hospital
Recruiting - verified April 2014

Sleep to Lower Elevated Blood Pressure

Conditions:   Hypertension;   Sleep Disorders;   Insomnia;   Cardiovascular Diseases
Intervention:   Behavioral: Online Sleep Education
Sponsors:   University College Hospital Galway;   Health Research Board, Ireland
Recruiting - verified April 2014

Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation in Latinamerica and EMEA Region

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified April 2014

Deep Brain Stimulation for Refractory Alcoholism

Condition:   Alcoholism
Intervention:   Procedure: Implantation of Deep Brain Stimulation
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified March 2014

A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD)

Condition:   Sickle Cell Disease
Interventions:   Drug: Prasugrel;   Drug: Placebo
Sponsors:   Eli Lilly and Company;   Daiichi Sankyo Inc.
Recruiting - verified April 2014

The Elderly ACS II Trial

Conditions:   Acute Coronary Syndrome;   Coronary Arteriosclerosis;   Myocardial Ischemia;   Cardiovascular Diseases
Interventions:   Drug: prasugrel;   Drug: Clopidogrel
Sponsors:   Arcispedale Santa Maria Nuova-IRCCS;   ANMCO Italian Association of Hospital Cardiologist;   Italian Society of Invasive Cardiology
Recruiting - verified April 2014

COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure.

Conditions:   Modified Release Oral Formulation;   Left Ventricular Systolic Dysfunction;   Chronic Heart Failure;   History of Chronic Heart Failure;   Left Ventricular Ejection Fraction;   Pharmacokinetics;   Echocardiogram
Interventions:   Drug: Omecamtiv mecarbil;   Drug: Omecamtiv mecarbil;   Drug: Placebo;   Drug: Omecamtiv Mecarbil;   Drug: Omecamtiv Mecarbil
Sponsors:   Amgen;   Cytokinetics
Recruiting - verified April 2014

Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation in Asia

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified April 2014

A Study on The Potential of Aleglitazar to Reduce Cardiovascular Risk in Patients With Stable Cardiovascular Disease and Glucose Abnormalities

Condition:   Cardiovascular Disease, Diabetes Mellitus, Type 2
Interventions:   Drug: aleglitazar;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Completed - verified April 2014

A Study Exploring Two Treatment Strategies in Patients With Atrial Fibrillation Who Undergo Catheter Ablation Therapy

Condition:   Atrial Fibrillation
Interventions:   Drug: rivaroxaban;   Drug: uninterrupted vitamin K antagonist (VKA)
Sponsor:   Janssen Scientific Affairs, LLC
Recruiting - verified April 2014

A Study to Assess Cardiovascular Outcomes Following Treatment With MK-3102 in Participants With Type 2 Diabetes Mellitus (MK-3102-018)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: MK-3102;   Drug: Placebo
Sponsor:   Merck Sharp & Dohme Corp.
Recruiting - verified April 2014

Vitamin D and Omega-3 Fatty Acids (VITAL Trial): Effects on Fractures

Condition:   Fractures
Interventions:   Dietary Supplement: Vitamin D3 placebo;   Dietary Supplement: Fish oil placebo;   Drug: omega-3 fatty acids (fish oil);   Dietary Supplement: Vitamin D3
Sponsors:   Brigham and Women's Hospital;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Active, not recruiting - verified April 2014

Danhong Injection in the Treatment of Acute Ischemic Stroke

Condition:   Acute Stroke
Interventions:   Drug: Danhong injection;   Procedure: Standard medical care;   Drug: placebo
Sponsors:   China Academy of Chinese Medical Sciences;   China: State Food and Drug Administration
Recruiting - verified April 2014

Cardiovascular Rehabilitation Early After Stroke Using Feedback-controlled Robotics-assisted Treadmill Exercise

Conditions:   Stroke;   Cardiovascular Diseases
Interventions:   Device: Feedback-controlled robotics-assisted treadmill exercise;   Device: Robotics-assisted treadmill exercise
Sponsors:   Bern University of Applied Sciences;   Maastricht University;   Reha Rheinfelden;   Swiss Federal Institute of Technology
Completed - verified April 2014

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2014

Paired Vagus Nerve Stimulation (VNS) With Rehabilitation for Upper Limb Function Improvement After Stroke

Condition:   Stroke
Interventions:   Device: Vivistim System;   Other: Rehab Only
Sponsor:   MicroTransponder Inc.
Active, not recruiting - verified April 2014

Comparison of Platelet Rich Plasma and Alternative Therapies for the Treatment of Tennis Elbow (Lateral Epicondylitis)

Condition:   Lateral Epicondylitis (Tennis Elbow)
Interventions:   Other: Platelet Rich Plasma (PRP) Injection;   Other: Whole Blood Injection;   Other: Dry Needle Fenestration;   Other: Sham Injection
Sponsors:   McMaster University;   Arthrex, Inc.;   The Physicians' Services Incorporated Foundation;   Radiological Society of North America
Recruiting - verified April 2014

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab SAR236553 (REGN727)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Other: placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified April 2014

Patient Centred Communication Intervention

Conditions:   Aphasia;   Stroke
Intervention:   Behavioral: Patient-Centred Communication Intervention
Sponsors:   University Health Network, Toronto;   Canadian Institutes of Health Research (CIHR)
Completed - verified April 2014

Study of Vitamin D and Omega-3 Supplementation for Preventing Diabetes

Condition:   Type 2 Diabetes
Interventions:   Dietary Supplement: Vitamin D3;   Drug: Omega-3 fatty acid (fish oil);   Dietary Supplement: Vitamin D3 placebo;   Drug: Fish oil placebo
Sponsors:   Brigham and Women's Hospital;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting - verified April 2014

Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsor:   Bayer
Active, not recruiting - verified April 2014

The 36-month Extension to Follow up Sub Study

Conditions:   Postphlebitic Syndrome;   Post-Thrombotic Syndrome;   Deep Vein Thrombosis
Intervention:  
Sponsors:   Sir Mortimer B. Davis - Jewish General Hospital;   Canadian Institutes of Health Research (CIHR);   Heart and Stroke Foundation of Canada;   Sigvaris Corporation
Active, not recruiting - verified April 2014

Very Intensive Early Walking in Stroke

Condition:   Stroke
Interventions:   Behavioral: Intensive Walking;   Behavioral: Conventional Physical Therapy
Sponsor:   Rehabilitation Institute of Chicago
Recruiting - verified April 2014

Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI).

Condition:   Severe Aortic Stenosis
Interventions:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI);   Procedure: Surgical Aortic Valve Replacement (SAVR)
Sponsor:   Medtronic Cardiovascular
Recruiting - verified April 2014

Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.

Condition:   Smoking Cessation
Interventions:   Drug: placebo;   Drug: varenicline tartrate;   Drug: bupropion hydrochloride;   Drug: Nicotine Replacement Therapy Patch
Sponsor:   Pfizer
Recruiting - verified April 2014

Structurally Reorganizing Motor Cortex in Stroke Patients Through Hebbian-type Stimulation

Condition:   Stroke
Interventions:   Device: Repetitive Transcranial Magnetic Stimulation (rTMS);   Device: Sham stimulation
Sponsors:   Emory University;   Cathrin Buetefisch;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified April 2014

Role of Ipsilateral Motor Cortex in Executing Movements With Increasing Demand on Precision

Condition:   Stroke
Intervention:  
Sponsors:   Emory University;   Cathrin Buetefisch;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2014

Interests of Strengthening Isokinetic Upper Extremity Hemiparetic Sequelae in Patients

Condition:   Partial Deficiency of Muscle Strength
Interventions:   Other: isokinetic strength training;   Other: passive motion
Sponsor:   University Hospital, Montpellier
Recruiting - verified April 2014

Effects of rTMS and tDCS on Motor Function in Stroke

Conditions:   Stroke;   Motor Function
Interventions:   Device: Repetitive Transcranial Magnetic Stimulation (rTMS);   Device: Transcranial Direct Current Stimulation (tDCS)
Sponsor:   Spaulding Rehabilitation Hospital
Active, not recruiting - verified April 2014

Active MOBility Early After Stroke : What Should be the Best Physiotherapy Early After Stroke ?

Condition:   Rehabilitation
Interventions:   Procedure: standard physiotherapy;   Procedure: experimental physiotherapy
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Ministry of Health, France
Recruiting - verified April 2014

Stroke Self-Management

Condition:   Stroke
Intervention:   Behavioral: Stroke Self-Management
Sponsor:   Department of Veterans Affairs
Recruiting - verified April 2014

A Prospective, Open Label Study Evaluating Two Management Strategies on Gastrointestinal Symptoms in Patients Newly on Treatment With Pradaxa for the Prevention of Stroke and Systemic Embolism With Non-valvular Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Drug: pantoprazole;   Drug: Pradaxa (dabigatran etexilate);   Drug: Pradaxa, within 30 minutes after a meal;   Drug: Pradaxa (dabigatran etexilate)
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2014

GLORIA-AF Registry Program - Second and Third Phases

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2014

Effects of Hormone Stimulation on Brain Scans for Cushing s Disease

Condition:   Pituitary Neoplasm
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 2013

A Study to Evaluate Cardiovascular Outcomes in Patients With Type 2 Diabetes Treated With ITCA 650

Condition:   Type 2 Diabetes
Interventions:   Drug: ITCA 650;   Other: ITCA placebo
Sponsor:   Intarcia Therapeutics
Recruiting - verified April 2014

Iloprost Therapy in Patients With Critical Limb Ischemia

Condition:   Peripheral Arterial Disease
Intervention:   Drug: Iloprost (Ilomedin, BAYQ6256)
Sponsor:   Bayer
Recruiting - verified April 2014

The Effect of the Hemobag® Ultrafiltration System on Blood Conservation and Coagulation After Cardiopulmonary Bypass

Condition:   Blood Coagulation Disorders
Intervention:   Device: method of returning residual CPB blood ( Hemobag®)
Sponsors:   Maine Medical Center;   Global Blood Resources, LLC
Recruiting - verified April 2014

Longitudinal Studies of Brain Structure and Function in MPS Disorders

Conditions:   Mucopolysaccharidosis Type I;   Mucopolysaccharidosis Type II;   Mucopolysaccharidosis Type VI
Intervention:  
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified April 2014

Adolescent Master Protocol

Condition:   HIV/AIDS
Intervention:  
Sponsors:   Harvard School of Public Health;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute on Drug Abuse (NIDA);   National Institute of Allergy and Infectious Diseases (NIAID);   National Institute of Mental Health (NIMH);   National Heart, Lung, and Blood Institute (NHLBI);   National Institute on Deafness and Other Communication Disorders (NIDCD);   National Institute on Alcohol Abuse and Alcoholism (NIAAA);   National Institute of Neurological Disorders and Stroke (NINDS);   Tulane University School of Medicine;   National Institute of Dental and Craniofacial Research (NIDCR);   Office of AIDS Research
Active, not recruiting - verified April 2014

PRISM Registry: Pseudobulbar Affect Registry Series

Conditions:   Alzheimer's Disease;   Amyotrophic Lateral Sclerosis (ALS);   Multiple Sclerosis (MS);   Parkinson's Disease;   Stroke;   Traumatic Brain Injury
Intervention:  
Sponsor:   Avanir Pharmaceuticals
Completed - verified April 2014

"Spot Sign" Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy

Condition:   Stroke
Interventions:   Biological: rfVIIa;   Other: Standard saline solution
Sponsors:   Sunnybrook Health Sciences Centre;   Dr. David Gladstone;   Canadian Institutes of Health Research (CIHR)
Recruiting - verified March 2014

Dystonia Coalition Projects

Conditions:   Dystonia;   Voice Disorders
Intervention:  
Sponsors:   Emory University;   Hyder A. Jinnah, MD, PhD;   National Institute of Neurological Disorders and Stroke (NINDS);   Office of Rare Diseases (ORD);   Allergan;   Dystonia Study Group
Recruiting - verified April 2014

Evaluation of Therapeutic Hypothermia in Convulsive Status EPILEPTICUS in Adults in Intensive Care

Condition:   Convulsive Status EPILEPTICUS
Intervention:   Procedure: Moderate hypothermia
Sponsor:   Assistance Publique - Hôpitaux de Paris
Suspended - verified April 2014

Gait Parameters Analysis in Post-stroke Patients and in Elderly Fallers

Conditions:   Healthy;   Thalamic Pain Syndrome;   Fallers
Intervention:   Other: Gait analysis
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting - verified April 2014

Allogeneic Genoidentical Stem Cell Transplantation in Children With Sickle-cell Anemia and Cerebral Vasculopathy

Conditions:   Sickle Cell Anemia;   Cerebrovascular Accident
Interventions:   Procedure: Stem cell transplantation;   Procedure: Transfusion program
Sponsor:   Assistance Publique - Hôpitaux de Paris
Active, not recruiting - verified April 2014

Observational Study on Determinants of Dementia After Stroke

Conditions:   Ischemic Stroke;   Hemorrhagic Stroke
Intervention:  
Sponsor:   Ludwig-Maximilians - University of Munich
Recruiting - verified April 2014

A Study of RoActemra/Actemra (Tocilizumab) in Comparison to Etanercept in Patients With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors

Condition:   Cardiovascular Disease, Rheumatoid Arthritis
Interventions:   Drug: tocilizumab [RoActemra/Actemra];   Drug: etanercept
Sponsor:   Hoffmann-La Roche
Active, not recruiting - verified April 2014

Task-oriented Training for Stroke: Impact on Function Mobility

Conditions:   Cerebrovascular Accident;   Stroke
Interventions:   Behavioral: High-intensity Treadmill Exercise;   Behavioral: Low-intensity Lifestyle Intervention
Sponsor:   Department of Veterans Affairs
Active, not recruiting - verified April 2014

The PARTNER II Trial: Placement of AoRTic TraNscathetER Valves

Condition:   Symptomatic Severe Aortic Stenosis
Interventions:   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis
Sponsor:   Edwards Lifesciences
Recruiting - verified April 2014

Surveillance Monitoring for ART Toxicities Study in HIV Uninfected Children Born to HIV Infected Women

Condition:   Antiretroviral Toxicity
Intervention:  
Sponsors:   Harvard School of Public Health;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute on Drug Abuse (NIDA);   National Institute of Allergy and Infectious Diseases (NIAID);   National Institute of Mental Health (NIMH);   National Heart, Lung, and Blood Institute (NHLBI);   National Institute on Deafness and Other Communication Disorders (NIDCD);   National Institute on Alcohol Abuse and Alcoholism (NIAAA);   National Institute of Neurological Disorders and Stroke (NINDS);   Tulane University School of Medicine;   National Institute of Dental and Craniofacial Research (NIDCR);   Office of AIDS Research
Recruiting - verified April 2014

Early Tracheostomy in Ventilated Stroke Patients

Conditions:   Ischemic Stroke;   Intracerebral Hemorrhage;   Subarachnoid Hemorrhage
Interventions:   Procedure: Early Tracheostomy;   Procedure: Late Tracheostomy
Sponsor:   Heidelberg University
Completed - verified April 2014

Post-prandial Lipid Effects of Raltegravir (RAL) vs Ritonavir -Boosted Darunavir (DRV-r) in Anti-retroviral Therapy (ART)- Naive Adults or Adults Recommencing ART.

Conditions:   HIV;   Cardiovascular Disease
Interventions:   Drug: raltegravir plus truvada;   Drug: Darunavir, ritonavir, tenofovir/emtricitabine (Truvada)
Sponsors:   St Vincent's Hospital, Sydney;   Merck Sharp & Dohme Corp.
Active, not recruiting - verified April 2014

Pulmonary Embolism and Stroke in Patient With Patent Foramen Ovale

Conditions:   Recent Stroke;   Pulmonary Embolism;   Patent Foramen Ovale
Intervention:  
Sponsor:   University Hospital, Brest
Recruiting - verified February 2014

EXCEL Clinical Trial

Conditions:   Chronic Coronary Occlusion;   Unprotected Left Main Coronary Artery Disease;   Stent Thrombosis;   Vascular Disease;   Myocardial Ischemia;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Artery Disease;   Coronary Restenosis
Interventions:   Device: Percutaneous Coronary Intervention;   Procedure: CABG
Sponsor:   Abbott Vascular
Active, not recruiting - verified April 2014

Ethanol Response in Essential Tremor: Clinical and Neurophysiological Correlates

Condition:   Essential Tremor
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2014

Neural Dynamics and Connectivity in Response Inhibition and Traumatic Brain Injury

Conditions:   Traumatic Brain Injury;   Stroke;   Headache;   PTSD
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS);   Department of Defense;   Center for Neuroscience and Regenerative Medicine (CNRM)
Recruiting - verified March 2014

Effect of Goal- Directed Crystalloid Versus Colloid Administration on Major Postoperative Morbidity

Condition:   Postoperative Complications
Interventions:   Other: Crystalloid;   Other: Colloid
Sponsor:   The Cleveland Clinic
Recruiting - verified April 2014

Anticoagulation in Stent Intervention

Conditions:   Atrial Fibrillation;   Stroke
Interventions:   Drug: Acetylsalicylic Acid + clopidogrel + acenocoumarol;   Drug: Acetylsalicylic Acid + clopidogrel
Sponsor:   Hospital Universitari Vall d'Hebron Research Institute
Recruiting - verified April 2014

Controlling Hypertension Outcomes by Improved Communication & Engagement

Conditions:   Hypertension;   Stroke
Intervention:   Behavioral: Four Habits Model
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Use of Transcranial Direct Current Stimulation (tDCS) Coupled With Constraint Induced Movement Therapy in Stroke Patient

Condition:   Stroke
Intervention:   Device: Transcranial Stimulation
Sponsor:   Spaulding Rehabilitation Hospital
Active, not recruiting - verified April 2014

Strength, Flexibility, And Balance Therapy After Stroke

Condition:   Stroke
Intervention:   Other: Yoga intervention focused on strength, flexibility, and balance therapy
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Electrical Stimulation for the Treatment of Post-Stroke Shoulder Pain

Condition:   Shoulder Pain
Intervention:   Device: The SPR System
Sponsor:   NDI Medical, LLC
Recruiting - verified April 2014

PeriOperative ISchemic Evaluation-2 Trial

Condition:   Cardiovascular Disease
Interventions:   Drug: Active Clonidine;   Drug: Placebo Clonidine;   Drug: Active ASA;   Drug: Placebo ASA
Sponsors:   McMaster University;   Hamilton Health Sciences Corporation
Active, not recruiting - verified April 2014

Post-authorization Safety Study of Etoricoxib and Other Anti-inflammatory Therapies in European Patients With Ankylosing Spondylitis (MK-0663-163)

Condition:   Ankylosing Spondylitis
Intervention:  
Sponsor:   Merck Sharp & Dohme Corp.
Active, not recruiting - verified April 2014

BAY81-8781, I.V. Aspirin in the Indication of Acute Coronary Syndrome (ACS)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Acetylsalicylic acid (Aspirin, BAY 81-8781);   Drug: Acetylsalicylic acid (Aspirin, BAY 81-8781);   Drug: Acetylsalicylic acid (Aspirin, BAY 81-8781)
Sponsor:   Bayer
Recruiting - verified April 2014

Pilot Study of Bumetanide for Newborn Seizures

Condition:   Seizures
Interventions:   Drug: Bumetanide;   Other: Normal Saline
Sponsors:   Soul, Janet , M.D.;   Citizens United for Research in Epilepsy;   Harvard Catalyst- Harvard Clinical and Translational Science Center;   Translational Research Program, Boston Children's Hospital;   Charles H. Hood Foundation;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2014

Action of Amantadine on Post-Stroke Aphasic Patients

Condition:   Cerebral Infarction
Interventions:   Drug: Amantadin;   Drug: Placebo
Sponsor:   Centre Hospitalier Universitaire de Nice
Completed - verified June 2013

The Assessment of Oxidative Stress Markers and the Development of Atrial Fibrillation After Cardiac Surgery

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   University of Illinois at Chicago
Terminated - verified April 2014

Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System

Conditions:   Central Nervous System Disease;   Multiple Sclerosis
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2014

Sitagliptin Cardiovascular Outcome Study (MK-0431-082)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Sitagliptin phosphate;   Drug: Placebo
Sponsors:   Merck Sharp & Dohme Corp.;   Duke Clinical Research Institute, Oxford Diabetes Trials Unit
Active, not recruiting - verified April 2014

Global Study to Assess the Safety and Effectiveness of Edoxaban (DU-176b) vs Standard Practice of Dosing With Warfarin in Patients With Atrial Fibrillation

Conditions:   Stroke;   Atrial Fibrillation;   Embolism
Interventions:   Drug: warfarin tablets;   Drug: Edoxaban tablets (high dose regimen);   Drug: Edoxaban tablets (low dose regimen)
Sponsors:   Daiichi Sankyo Inc.;   The TIMI Study Group
Completed - verified April 2014

Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III

Condition:   Intraventricular Hemorrhage
Interventions:   Drug: Cathflo Activase;   Other: Normal saline
Sponsors:   Johns Hopkins University;   Daniel Hanley;   National Institute of Neurological Disorders and Stroke (NINDS);   Genentech;   Emissary International LLC
Recruiting - verified April 2014

A Study of All-Cause Mortality and Cardiovascular Morbidity in CKD Patients on Dialysis and Those Not on Renal Replacement Therapy Receiving Mircera or Reference ESAs.

Condition:   Anemia
Interventions:   Drug: methoxy polyethylene glycol-epoetin beta [Mircera];   Drug: methoxy polyethylene glycol-epoetin beta [Mircera];   Drug: ESAs (darbepoetin alfa, epoetin alfa or epoetin beta)
Sponsor:   Hoffmann-La Roche
Active, not recruiting - verified April 2014

Biomarkers of Risk of Parkinson Disease

Conditions:   Parkinson Disease;   Autonomic Nervous System Diseases;   Pure Autonomic Failure
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2014

The VA Diabetes Trial Follow-up Study (VADT-FS)

Conditions:   Diabetes;   Glycemic Control
Intervention:  
Sponsor:   Department of Veterans Affairs
Active, not recruiting - verified April 2014

Efficacy and Safety Study of Apixaban for the Treatment of Deep Vein Thrombosis or Pulmonary Embolism

Condition:   Venous Thrombosis
Interventions:   Drug: Enoxaparin;   Drug: warfarin;   Drug: Placebo for apixaban;   Drug: Placebo for enoxaparin;   Drug: Placebo for warfarin;   Drug: apixaban
Sponsors:   Bristol-Myers Squibb;   Pfizer
Completed - verified April 2014

Hyper- and Hypokalemic Periodic Paralysis Study

Conditions:   Hyperkalemic Periodic Paralysis;   Hypokalemic Periodic Paralysis
Interventions:   Drug: Dichlorphenamide (double-blind);   Drug: Placebo (double-blind);   Drug: Dichlorphenamide (open-label)
Sponsors:   University of Rochester;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 2014

Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome

Condition:   Antiphospholipid Syndrome
Intervention:  
Sponsor:   Duke University
Recruiting - verified February 2014

Brain Peripheral Benzodiazepine Receptors in Patients With Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 2014

Evaluating the Relationship Between Fatty Acids and Heart Disease

Conditions:   Cardiovascular Diseases;   Heart Failure, Congestive;   Atrial Fibrillation;   Cerebrovascular Accident
Intervention:  
Sponsors:   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI);   Office of Dietary Supplements (ODS)
Completed - verified April 2014

Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

Condition:   HTLV-1
Intervention:   Drug: Hu MiK-Beta-1
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Suspended - verified April 2014

The Role of Cytokine-Serotonin Interactions in Post-Stroke Depression

Condition:   Depression
Intervention:   Drug: Citalopram
Sponsor:   Sunnybrook Health Sciences Centre
Active, not recruiting - verified April 2014

Hypertension Intervention Nurse Telemedicine Study (HINTS)

Condition:   Hypertension
Interventions:   Behavioral: Nurse Behavioral intervention with Home BP Telemonitoring;   Behavioral: Nurse Medication Management with Home BP Telemonitoring;   Behavioral: Nurse Combined intervention with Home BP Telemonitoring
Sponsor:   Department of Veterans Affairs
Completed - verified April 2014

Measuring Levels of SMN in Blood Samples of SMA Patients

Condition:   Spinal Muscular Atrophy
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 2014

Get CardioSmart

You're Invited