Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Sensory-driven Motor Recovery in Poorly Recovered Subacute Stroke Patients

Conditions:   Stroke;   Cerebrovascular Accident
Intervention:   Device: S88 Dual Output Stimulator by Grass Technologies
Sponsor:   Lumy Sawaki
Completed - verified April 2017

Optimizing Transcranial Direct Current Stimulation for Motor Recovery From Hemiparesis

Conditions:   Stroke;   Cerebrovascular Accident
Intervention:   Device: Neuroconn Eldith stimulator by Magstim
Sponsor:   Lumy Sawaki
Completed - verified April 2017

Trans Cranial Brain Stimulation for Stroke Rehabilitation

Condition:   Stroke
Interventions:   Other: Transcranial direct stimulation;   Other: Transcranial Magnetic stimulation;   Other: Transcranial direct stimulation with mental imagery;   Other: Transcranial magnetic stimulation with mental imagery
Sponsors:   Majmaah University;   Deanship of scientific research, Majmaah Uinversity
Recruiting - verified April 2017

Recovery of Upper Limb Paresis at Discharge After Stroke and Its Level of Use in Activities of Daily Living 3 to 6 Months Later (Post AVC-AVQ)

Condition:   Stroke Rehabilitation
Intervention:   Diagnostic Test: Scale Action Research Arm Test (ARAT)
Sponsor:   University Hospital, Bordeaux
Not yet recruiting - verified April 2017

Scalp Acupuncture Combined rTMS on Brain White Matter Microstructure of Hemiplegic Patients With Stroke

Condition:   Stroke
Interventions:   Other: the experimental group;   Other: the control group
Sponsor:   Shenzhen Sixth People's Hospital
Active, not recruiting - verified April 2017

Improving Stroke Prevention in Atrial Fibrillation Through Pharmacist Prescribing

Conditions:   Atrial Fibrillation;   Stroke
Intervention:   Drug: Anticoagulants
Sponsors:   University of Alberta;   Heart and Stroke Foundation of Canada;   Canadian Stroke Prevention Intervention Network
Recruiting - verified April 2017

Use of Direct Oral Anticoagulants in UK

Condition:   Stroke
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Dabigatran;   Drug: Apixaban
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Not yet recruiting - verified April 2017

Scalp Acupuncture for Dyskinesia After Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Other: Scalp acupuncture;   Other: Conventional rehabilitation
Sponsors:   Shanghai University of Traditional Chinese Medicine;   Fudan University
Recruiting - verified April 2017

Effect of Bilateral TENS With TOT on Upper Limb Function in Patients With Chronic Stroke

Condition:   Stroke
Interventions:   Behavioral: Task-orientated training;   Device: Transcutaneous electrical nerve stimulation (TENS);   Device: Sham electrical nerve stimulation
Sponsor:   The Hong Kong Polytechnic University
Recruiting - verified April 2017

Does Participation in a Group, Task-oriented Community-based Exercise Program Improve the Ability to do Everyday Activities Among People With Stroke?

Conditions:   Stroke;   Balance;   Mobility Limitation;   Activities of Daily Living
Intervention:   Behavioral: Together in Movement and Exercise (TIME) Program
Sponsors:   University of Toronto;   Toronto Rehabilitation Institute-University Health Network;   Heart and Stroke Foundation of Canada;   Scarborough and Rouge Hospital-Centenary site;   St. Joseph's Healthcare-Parkwood Institute;   Pembroke Regional Hospital;   Toronto PanAm Sports Centre;   Bob Hayward YMCA, London;   Best Western Inn Pembroke Fitness Centre;   Western University;   Ontario Stroke Network;   Institute for Clinical Evaluative Sciences
Recruiting - verified April 2017

Daily Light Exposure for Sleep Disturbance, Fatigue, and Functional Outcomes in Acute Brain Injury

Conditions:   Stroke;   Traumatic Brain Injury;   Non-traumatic Brain Injury
Intervention:   Other: Philips GoLite Blu HF3429/60 or Philips LivingColor Aura 70998/60/48
Sponsors:   St. Luke's Rehabilitation Institute;   Washington State University
Recruiting - verified April 2017

The Effect of Cilostazol Compared to Aspirin on Endothelial Function in Acute Cerebral Ischemia Patients

Conditions:   Ischemic Stroke;   Endothelial Dysfunction
Interventions:   Drug: Cilostazol 100mg;   Drug: Aspirin
Sponsor:   Ajou University School of Medicine
Completed - verified April 2017

A Pilot Study on the Prevention of the Vascular RISK Related to Atrial Fibrillation After Intracranial Hemorrhage by Closing the Left Auricle

Conditions:   Atrial Fibrillation;   Intracranial Hemorrhages
Intervention:   Diagnostic Test: Compare the risk of a vascular event
Sponsor:   Centre Hospitalier Universitaire, Amiens
Recruiting - verified April 2017

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics (CREST-H)

Conditions:   Internal Carotid Artery Stenosis;   Cognitive Impairment
Intervention:  
Sponsors:   Columbia University;   National Institute of Neurological Disorders and Stroke (NINDS);   Mayo Clinic;   University of Alabama at Birmingham;   University of Maryland
Not yet recruiting - verified April 2017

The Association of Omentin and Ischemic Stroke

Conditions:   Stroke;   Brain Ischemia;   Adipokines;   Mutation
Intervention:  
Sponsor:   Xi'an No.3 Hospital
Recruiting - verified April 2017

Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

Condition:   Multiple Sclerosis
Interventions:   Drug: Pioglitazone;   Drug: Montelukast;   Drug: Losartan;   Drug: Hydroxychloroquine
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 6, 2017

Predictors and Prognostic Factors on the Acute Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: Drug Therapy;   Diagnostic Test: Routine Blood Test and Image Scan;   Other: Intravascular therapy;   Other: Emergency Treatment;   Other: Medical history
Sponsor:   Tongji Hospital
Not yet recruiting - verified April 2017

Patient Management During Major Abdominal Surgery: an Oxygen Consumption Protocol Compared to Standard Approach

Condition:   Hemodynamic Instability
Intervention:   Other: Oxygen consumption optimization
Sponsors:   Antonio Dell'Anna;   Flavia Torrini;   Alessandra Bisanti;   Eleonora Filipponi;   Domenica Luca Grieco;   Massimo Antonelli
Not yet recruiting - verified April 2017

Physical Activity in Reducing Metabolic Dysregulation (MetD) in Obese Latina Breast Cancer Survivors

Conditions:   Cancer Survivor;   Central Obesity;   No Evidence of Disease
Interventions:   Other: Best Practice;   Behavioral: Exercise Intervention;   Behavioral: Exercise Intervention;   Other: Laboratory Biomarker Analysis;   Device: Monitoring Device;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
Sponsors:   University of Southern California;   National Cancer Institute (NCI)
Not yet recruiting - verified April 2017

Managing Aftercare for Stroke (MAS): MAS-II - A Longitudinal Complex-interventional Study in Post-rehabilitation Stroke Patients

Condition:   Stroke
Intervention:   Other: comprehensive multidisciplinary stroke care
Sponsors:   Charite University, Berlin, Germany;   Center for Stroke Research Berlin;   Hebrew University of Jerusalem;   NeuroCure Clinical Research Center
Recruiting - verified April 2017

The Feasibility of a Web-based Application to Monitor Home Blood Pressure

Condition:   Hypertension
Intervention:   Other: Direct input of home blood pressure readings via MyChart
Sponsor:   Loyola University
Enrolling by invitation - verified April 2017

ACEI/ARB Study in Ambulatory and Day of Surgery Admission Patients

Conditions:   Hypertension;   Hypotension
Intervention:   Drug: ACEI or ARB
Sponsor:   State University of New York - Downstate Medical Center
Terminated - verified April 2017

Physical Therapy and Occupational Therapy After Transcatheter Aortic Valve Replacement

Condition:   Transcatheter Aortic Valve Implantation
Interventions:   Other: Post procedure daily PT and OT;   Other: PT post procedure;   Other: OT post procedure;   Other: Routine PT or OT
Sponsors:   Henry Ford Health System;   Henry Ford Hospital
Enrolling by invitation - verified April 2017

Vitamin C in Cardiac Surgery Patients

Condition:   Coronary Artery Bypass Graft Surgery
Intervention:   Drug: Ascorbic Acid
Sponsors:   Geisinger Clinic;   Wilkes University
Not yet recruiting - verified April 2017

Effectiveness of the Geriatric Activation Program Pellenberg (GAPP) on the Geriatric Rehabilitation Ward

Conditions:   Stroke;   Hip Fractures;   Abdominal Injury;   Chronic Obstructive Pulmonary Disease
Intervention:   Other: Geriatric Activation Program Pellenberg
Sponsors:   Katholieke Universiteit Leuven;   Universitaire Ziekenhuizen Leuven
Recruiting - verified April 2017

Ketamine Versus Low Dose Thiopental for Induction of Anesthesia in Septic Shock

Condition:   Septic Shock
Interventions:   Drug: Ketamine;   Drug: Thiopental
Sponsor:   Cairo University
Recruiting - verified April 2017

Chronic Subdural Hematoma and Aspirin

Condition:   Chronic Subdural Hematoma
Interventions:   Drug: Acetylsalicylic acid;   Drug: Placebo Oral Tablet
Sponsor:   University Hospital, Basel, Switzerland
Not yet recruiting - verified April 2017

Comparison of Pupilometer and Ultrasound of Optic Nerve Sheath Diameter in Estimating Intracranial Pressure (ICP)

Conditions:   Intracranial Hemorrhages;   Brain Injuries;   Subarachnoid Hemorrhage;   Ischemic Stroke;   Stroke
Intervention:  
Sponsor:   Loma Linda University
Not yet recruiting - verified April 2017

Sleep as a Model to Understand and Manipulate Cortical Activity in Order to Promote Functional Recovery After Stroke

Condition:   Hemispatial Neglect
Interventions:   Device: Transcranial Magnetic Stimulation (TMS);   Device: Transcranial Alternating Current Stimulation (tACS);   Device: sham Transcranial Magnetic Stimulation (TMS);   Device: sham Transcranial Alternating Current Stimulation (tACS)
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified April 2017

P2Y12 Inhibitor Monotherapy Versus Extended DAPT in Patients Treated With Bioresorbable Scaffold

Conditions:   Coronary Artery Disease;   Stents;   Atherosclerosis
Interventions:   Drug: Clopidogrel;   Drug: Ticagrelor;   Drug: Aspirin
Sponsor:   Samsung Medical Center
Not yet recruiting - verified April 2017

The Treatment Effectiveness of Combined tDCs and Neurofeedback (NF) for Patients With Cognitive Deficits After Stroke

Conditions:   Stroke;   Cognitive Impairment
Interventions:   Device: tDCS & neurofeedback;   Device: neurofeedback;   Device: sham neurofeedback
Sponsors:   Kowloon Hospital, Hong Kong;   Chinese University of Hong Kong
Recruiting - verified April 2017

Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabeTes (PROMINENT)

Conditions:   Type2 Diabetes;   Dyslipidemia
Interventions:   Drug: K-877;   Drug: Placebo
Sponsors:   Kowa Research Institute, Inc.;   Brigham and Women's Hospital
Recruiting - verified April 2017

Does Choral Singing Help imprOve Stress in Patients With Ischemic HeaRt Disease?

Conditions:   Ischemic Heart Disease;   Coronary Heart Disease;   Myocardial Infarction
Intervention:   Behavioral: Choral Singing
Sponsors:   Nova Scotia Health Authority;   Dalhousie University
Not yet recruiting - verified April 2017

Patient Perceptions and Physician Assessment of Benefits and Risks of Oral Anticoagulation Due to Non-valvular AF

Conditions:   Atrial Fibrillation;   Health Literacy
Intervention:   Other: Questionnaire
Sponsor:   Medical University of Graz
Active, not recruiting - verified April 2017

High-resolution MRI of Inflammation in the Intracranial Arterial Vessel Wall

Condition:   Stroke
Intervention:   Drug: Ferumoxytol Injectable Product
Sponsors:   University of Utah;   AMAG Pharmaceuticals, Inc.
Not yet recruiting - verified April 2017

Neurophysiologic Study of Patient With Essential Tremor and Dystonic Tremor

Conditions:   Essential Tremor;   Cervical Dystonia;   Focal Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 5, 2017

Hypertension in Long-Term Care Facilities

Condition:   Hypertension
Intervention:   Other: Chart review
Sponsor:   Louisiana State University Health Sciences Center in New Orleans
Recruiting - verified April 2017

The Comparative Safety and Effectiveness of Dabigatran, Versus Rivaroxaban, and Apixaban Utilized in the Department of Defense Non-Valvular Atrial Fibrillation Patient Population: A Retrospective Database Analysis

Condition:   Atrial Fibrillation
Interventions:   Drug: Dabigatran vs. Rivaroxaban;   Drug: Dabigatran vs. Apixaban
Sponsors:   Boehringer Ingelheim;   Health ResearchTx, LLC (HRTX);   inVentiv Health Clinical (iVH);   United States Department of Defense (DOD)
Recruiting - verified April 2017

Clinical and Physiological Studies of Tremor Syndromes

Conditions:   Parkinson Disease;   Dystonia;   Essential Tremor
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 16, 2017

Electric Field Navigated 1hz Rtms for Post-stroke Motor Recovery Trial

Condition:   Ischemic Stroke
Interventions:   Device: Nexstim NBS guided active rTMS;   Device: Nexstim NBS guided sham rTMS
Sponsor:   Nexstim Ltd
Recruiting - verified April 2017

A Study to Evaluate the Safety and Effectiveness of the Left Atrial Appendage Closure Therapy Using BSJ003W

Condition:   Atrial Fibrillation Non-Rheumatic
Intervention:   Device: BSJ003W
Sponsor:   Boston Scientific Japan K.K.
Recruiting - verified April 2017

Neurophysiology of Surround Inhibition in the Human Motor Cortex

Condition:   Normal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 27, 2017

Quality of Care of Children With Sickle Cell Disease (SCD) Screened at Birth in France

Conditions:   New-borns Screening;   Sickle Cell Disease
Intervention:   Other: No intervention
Sponsors:   Assistance Publique - Hôpitaux de Paris;   CNAMTS;   AFDPHE;   National reference center for thalassemia;   National laboratories in charge of the SCD new born screening;   Reference and competence centers for RBC disorders
Completed - verified December 2016

Partial Blocks of Rectus Femoris and Soleus With Botulinum Toxin Type A (Xeomin®) to Improve Gait in Hemiparesis

Conditions:   Hemiparesis After Stroke;   Traumatic Brain Injury
Interventions:   Drug: Placebo injection;   Drug: Botulinum toxin injection;   Drug: Placebo injection and botulinum toxin injection
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Merz Pharmaceuticals GmbH
Recruiting - verified December 2016

Validation of Predictors of OAC Initiation Using EMR Data

Condition:   Atrial Fibrillation
Interventions:   Drug: Dabigatran etexilate;   Drug: Warfarin
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2017

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

Condition:   Mitral Valve Failure
Interventions:   Device: Edwards SAPIEN 3 transcatheter heart valve;   Device: ASHI INTECC Astato XS 20
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified January 3, 2017

A Novel Mechanics-based Intervention to Improve Post-stroke Stability

Condition:   Stroke
Interventions:   Behavioral: Error reduction;   Behavioral: Error augmentation;   Behavioral: Activity matched control
Sponsor:   VA Office of Research and Development
Recruiting - verified April 2017

Fear of Falling in Patients With Chronic Stroke

Condition:   Stroke
Interventions:   Behavioral: GHE + TOBT training;   Behavioral: CBT + TOBT training
Sponsor:   The Hong Kong Polytechnic University
Recruiting - verified April 2017

Reappraisal of Atrial Fibrillation: RACE V - Work Package 5

Condition:   Atrial Fibrillation
Intervention:   Device: Implantable loop recorder
Sponsor:   Academisch Ziekenhuis Maastricht
Recruiting - verified April 2017

Effects of Prism Adaption and rTMS on Brain Connectivity and Visual Representation

Conditions:   Normal Physiology;   Stroke
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 12, 2016

Cerebral Perfusion Associated With Postural Changes: an ASL MR Perfusion Study

Condition:   Brain Ischemia
Intervention:   Procedure: MRI
Sponsor:   University Hospital Center of Martinique
Recruiting - verified April 2017

Deep Brain Stimulation Surgery for Focal Hand Dystonia

Conditions:   Dystonia;   Focal Dystonia;   Musician's Dystonia
Intervention:   Procedure: DBS surgery
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified February 23, 2017

Oral Health Promotion Interventions Amongst Stroke Survivors During Rehabilitation

Condition:   Stroke
Interventions:   Device: Powered toothbrush;   Device: Manual toothbrush;   Other: Toothpaste;   Other: 0.2% chlorhexidine gluconate mouth rinse
Sponsors:   The University of Hong Kong;   Tung Wah Hospital
Completed - verified April 2017

AFQ056 for Language Learning in Children With FXS

Condition:   Fragile X Syndrome
Interventions:   Drug: AFQ056;   Other: Placebo;   Other: Language Intervention
Sponsors:   Elizabeth Berry-Kravis;   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified April 2017

Effects of Lipid Emulsion on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.

Conditions:   Drug Overdose;   Overdose of Beta-adrenergic Blocking Drug;   Blood Pressure
Interventions:   Drug: metoprolol;   Drug: intravenous lipid emulsion;   Drug: Sodium chloride 0.9% solution - lipid emulsion dummy;   Drug: Sodium chloride 0.9% solution - metoprolol dummy
Sponsor:   Mikkel Bring Christensen
Completed - verified April 2017

Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Dialysis (ASCEND-D)

Condition:   Anaemia
Interventions:   Drug: Daprodustat;   Drug: rhEPO;   Drug: Placebo;   Drug: Iron therapy
Sponsor:   GlaxoSmithKline
Recruiting - verified April 2017

Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND)

Condition:   Anaemia
Interventions:   Drug: Daprodustat;   Drug: Darbepoetin alfa;   Drug: Placebo;   Drug: Iron Therapy
Sponsor:   GlaxoSmithKline
Recruiting - verified April 2017

Clinical Algorithm for Post-Stroke Gait Training With C-Brace

Conditions:   Hemiparesis Due to Stroke;   Hemiplegia Due to Stroke
Intervention:   Device: C-Brace
Sponsors:   The University of Texas Health Science Center, Houston;   Otto Bock Healthcare Products GmbH
Recruiting - verified April 2017

Transfusion Using Stored Fresh Whole Blood

Conditions:   Trauma;   Hemorrhage;   Coagulopathy
Intervention:  
Sponsor:   University of California, Los Angeles
Not yet recruiting - verified April 2017

Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31

Condition:   Hereditary Spastic Paraplegia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 19, 2016

Comparing Constraint-Induced Therapy and Occupation-Based Intervention for Optimal Stroke Recovery

Conditions:   Stroke;   Cerebrovascular Accident
Interventions:   Behavioral: Occupation-based practice (OBP);   Behavioral: Modified-constraint induced therapy (m-CIT)
Sponsor:   Lumy Sawaki
Completed - verified April 2017

Intraoperative Ultrasound in Laparoscopic or Robotic Myomectomy Patients

Conditions:   Fibroid Uterus;   Quality of Life
Intervention:   Procedure: Intraoperative contact ultrasonography
Sponsors:   Cleveland Clinic Florida;   BK Ultrasound
Recruiting - verified May 2016

Comparison of Pneumoinsufflation Modes and Pressure Settings in Gynecology

Conditions:   Pain;   Pneumoperitoneum;   Inflammation;   Quality of Life
Intervention:   Procedure: Pneumoinsufflator mode and setting
Sponsors:   The Cleveland Clinic;   ConMed Corporation
Recruiting - verified April 2017

CADASIL Disease Discovery

Conditions:   Cardiovascular Disease;   Arterial Stiffness
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified December 7, 2016

Southeastern Collaboration to Improve Blood Pressure Control

Condition:   Hypertension
Interventions:   Behavioral: Practice Facilitation;   Behavioral: Peer Coach;   Behavioral: Enhanced usual care
Sponsor:   University of Alabama at Birmingham
Not yet recruiting - verified April 2017

Post-stroke Neural Plasticity With Atomoxetine

Conditions:   Atomoxetine Hydrochloride;   Placebos
Interventions:   Drug: Atomoxetine;   Drug: Placebo
Sponsor:   Lumy Sawaki
Completed - verified April 2017

Innovative Multigenerational Household Intervention to Reduce Stroke and CVD

Conditions:   Stroke;   Cardiovascular Disease
Interventions:   Behavioral: Motivational Interviewing Intervention Arm;   Other: Control Brochure Arm
Sponsor:   Washington State University
Active, not recruiting - verified April 2017

Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

Condition:   Multiple Sclerosis
Interventions:   Drug: Methylprednisolone;   Drug: Methylprednisolone
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified February 16, 2017

Xarelto on Prevention of Stroke and Non-central Nervous System Systemic Embolism in Patients With Non-valvular Atrial Fibrillation in China: A Non-interventional Study

Condition:   Stroke
Intervention:   Drug: Rivaroxaban (Xarelto, BAY 59-7939)
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting - verified April 2017

Growth Hormone Therapy for Muscle Regeneration in Severely Burned Patients

Conditions:   Burns;   Growth Hormone Treatment
Interventions:   Drug: Somatropin;   Drug: 0.09% Saline Solution
Sponsors:   The University of Texas Medical Branch, Galveston;   United States Department of Defense;   Pfizer
Recruiting - verified September 2016

Protocol-guided Rapid Evaluation of Veterans Experiencing New Transient Neurological Symptoms

Conditions:   Transient Ischemic Attack;   Stroke
Intervention:   Other: Quality Improvement Program
Sponsor:   VA Office of Research and Development
Recruiting - verified April 2017

Thrombolytic Care During Inter-hospital Transfer

Condition:   Stroke
Intervention:   Drug: Tissue Plasminogen Activator
Sponsor:   University of Iowa
Recruiting - verified April 2017

CT COMPARE: CT COronary Angiography to Measure PlAque REduction

Condition:   Cardiovascular Disease
Interventions:   Drug: Rosuvastatin;   Drug: Atorvastatin
Sponsor:   National Institutes of Health Clinical Center (CC)
Recruiting - verified April 3, 2017

The Medtronic TAVR 2.0 US Clinical Study

Condition:   Aortic Valve Stenosis
Intervention:   Device: Medtronic Transcatheter Aortic Valve 2.0 Replacement System
Sponsor:   Medtronic Cardiovascular
Active, not recruiting - verified April 2017

Apixaban in the Prevention of Stroke and Systemic Embolism in Patients With Atrial Fibrillation in Real-Life Setting in France

Condition:   Anticoagulation
Intervention:   Drug: Apixaban
Sponsor:   Bristol-Myers Squibb
Completed - verified March 2017

Safety and Efficacy of Intravenous Natalizumab in Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke
Interventions:   Drug: natalizumab;   Drug: Placebo
Sponsor:   Biogen
Recruiting - verified April 2017

Rate of Atrial Fibrillation Through 12 Months in Patients With Recent Ischemic Stroke of Presumed Known Origin

Condition:   Stroke, Acute
Intervention:   Device: Reveal LINQ™ Insertable Cardiac Monitor
Sponsor:   Medtronic Cardiac Rhythm and Heart Failure
Recruiting - verified April 2017

SPRITE - A Feasibility and Pilot Study

Condition:   Cerebrovascular Disorders
Interventions:   Other: 'The Healthy Brain Rehabilitation Manual';   Device: Pedometer;   Procedure: Usual care;   Behavioral: Telephone follow-up
Sponsors:   Queen's University, Belfast;   National Institute for Health Research, United Kingdom
Recruiting - verified April 2017

Investigational Device Evaluation of the WATCHMAN FLX™ LAA Closure Technology

Condition:   Atrial Fibrillation
Intervention:   Device: WATCHMAN FLX LAA closure device
Sponsor:   Boston Scientific Corporation
Withdrawn - verified March 2016

Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy With Ex Vivo Generated Polyomavirus-Specific T-Cells

Condition:   Leukoencephalopathy
Interventions:   Biological: PyVST;   Other: No Intervention
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 13, 2017

A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Recruiting - verified April 2017

Pipeline Flex With SHield Technology Embolization - An International MulticEnter ObservationaL Post Market StuDy

Condition:   Intracranial Aneurysm
Intervention:   Device: Pipeline™ Flex Embolization Device with Shield Technology™
Sponsors:   Medtronic Neurovascular Clinical Affairs;   Medtronic Bakken Research Center
Recruiting - verified April 2017

Cholinergic Receptor Imaging in Dystonia

Conditions:   Cervical Dystonia;   Dystonia;   Movement Disorder;   Focal Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 13, 2017

Safety and Efficacy Study of a Protease Activated Receptor-4 Antagonist Being Tested to Reduce the Chances of Having Additional Strokes or "Mini Strokes"

Condition:   Thrombosis
Interventions:   Drug: BMS-986141;   Drug: Aspirin;   Other: Placebo
Sponsor:   Bristol-Myers Squibb
Completed - verified March 2017

Myalgic Encephalomyelitis Chronic Fatigue at the National Institutes of Health

Condition:   Chronic Fatigue Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 29, 2017

The PARTNER 3 - Trial - The Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis

Condition:   Aortic Stenosis
Interventions:   Procedure: Surgical aortic valve replacement (SAVR);   Device: Transcatheter Aortic Valve Replacement (TAVR)
Sponsor:   Edwards Lifesciences
Recruiting - verified April 2017

Preload Dependency Evaluation With Stroke Volume Variation During Alveolar Recruitment Manoeuvres

Conditions:   Coronary Artery Disease;   Coronary Artery Bypass;   Hypovolemia;   Anesthesia, General;   Pulmonary Atelectasis
Interventions:   Other: tee measurement;   Other: flotrac measurement;   Other: clearsight measurement
Sponsor:   University Hospital, Clermont-Ferrand
Completed - verified April 2017

Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

Condition:   Aortic Valve Stenosis
Interventions:   Device: SAPIEN 3 THV;   Biological: Optimal Heart Failure Therapy
Sponsors:   Cardiovascular Research Foundation, New York;   Cardialysis BV;   Boston Biomedical Associates LLC
Recruiting - verified April 2017

Pathological Basis of MRI Signal Changes in Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 6, 2016

A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Advanced Prostate Cancer and Cardiovascular Disease

Condition:   Prostate Cancer
Interventions:   Drug: Degarelix;   Drug: Leuprolide
Sponsors:   Ferring Pharmaceuticals;   Memorial Sloan Kettering Cancer Center;   Duke Clinical Research Institute
Recruiting - verified April 2017

Tumor Related Epilepsy

Conditions:   Epilepsy;   Cancer;   Brain Neoplasm
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 14, 2017

Enhancing Plasticity in Stroke Patients With Severe Motor Deficit

Conditions:   Stroke;   Cerebrovascular Accident
Intervention:   Device: S88 Dual Output Stimulator by Grass Technologies
Sponsor:   Lumy Sawaki
Completed - verified April 2017

Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD

Conditions:   Obstructive Sleep Apnea;   PTSD;   Posttraumatic Stress Disorder
Interventions:   Behavioral: CBT-OSA;   Behavioral: Sleep Education
Sponsor:   VA Office of Research and Development
Recruiting - verified April 2017

Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli

Condition:   Normal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 24, 2017

Pushing Spatiotemporal Limits for 4D Flow MRI and Dynamic MRA in the Brain at Ultra-High Field

Condition:   Stroke
Intervention:   Device: 7 Tesla MRI
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Not yet recruiting - verified April 2017

Implantable Cardiac Monitors in High-Risk Post-Infarction Patients With Cardiac Autonomic Dysfunction

Conditions:   Myocardial Infarction;   Autonomic Nervous System Diseases
Intervention:   Device: Medtronic Reveal LINQ implantable cardiac monitor
Sponsors:   Klinikum der Universitaet Muenchen;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK);   Medtronic Bakken Research Center
Recruiting - verified April 2017

The Effect of Activity Feedback Enabled by Smart Watches During In-patient Stroke Rehabilitation

Condition:   Stroke
Interventions:   Behavioral: Feedback against tailored target;   Behavioral: No feedback
Sponsors:   The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine;   Oxford Brookes University;   Oxford International Rehabilitation Foundation and Innovation;   University of Warwick
Recruiting - verified March 2017

Special Drug Use Investigation of Xarelto for Venous Thromboembolism (VTE)

Condition:   Venous Thromboembolism
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting - verified April 2017

Assessment of Loading With the P2Y12 Inhibitor Ticagrelor or Clopidogrel to Halt Ischemic Events in Patients Undergoing Elective Coronary Stenting

Conditions:   Coronary Artery Disease;   Myocardial Ischemia;   Myocardial Infarction;   Stent Thrombosis;   Cardiovascular Diseases
Interventions:   Drug: Ticagrelor;   Drug: Clopidogrel
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Action Research Group
Recruiting - verified April 2017

Global Study Comparing a rivAroxaban-based Antithrombotic Strategy to an antipLatelet-based Strategy After Transcatheter aortIc vaLve rEplacement to Optimize Clinical Outcomes

Condition:   Transcatheter Aortic Valve Replacement
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Acetylsalicylic acid;   Drug: Clopidogrel
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting - verified April 2017

Assessment of Arrhythmias in Patients Undergoing Transcatheter Aortic Valve Implantation Using a Small Insertable Cardiac Monitoring Device

Condition:   Aortic Valve Stenosis
Intervention:  
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified April 2017

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified April 2017

Epidemiological Study on the Safety of Aspirin in The Health Improvement Network (THIN)

Conditions:   Secondary Prevention;   Stroke;   Ischemic Heart Disease;   Coronary Heart Disease
Interventions:   Drug: Acetylsalicylic Acid (Asprin, BAYE4465);   Drug: Clopidogrel, Oral Anticoagulants, NSAIDs and SSRIs
Sponsor:   Bayer
Completed - verified April 2017

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

Condition:   Epilepsy
Intervention:   Drug: Mangafodipir
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Suspended - verified October 12, 2016

Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection

Conditions:   HIV Infections;   Neurologic Disorders
Intervention:   Drug: Anakinra
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Johns Hopkins University
Enrolling by invitation - verified March 16, 2017

Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain

Conditions:   Intractable Pain;   Palliative Care;   Neoplasm Metastasis;   Questionnaires &Amp; Surveys
Intervention:   Drug: Resiniferatoxin
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Suspended - verified October 12, 2016

Propensity to Develop Plasticity in the Parieto- and Cerebello-Motor Networks in Dystonia From the Perspective of Abnormal High-Order Motor Processing

Conditions:   Writer's Cramp;   Healthly Volunteers;   Cervical Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 1, 2017

In Vivo Characterization of Inflammation With Ferumoxytol, an Ultrasmall Superparamagnetic Iron Oxide Nanoparticle, on 7 Tesla Magnetic Resonance Imaging

Condition:   Multiple Sclerosis
Intervention:   Drug: Ferumoxytol
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified March 6, 2017

Natural History of Multiple Sclerosis and Its Mimickers

Conditions:   Neurologic Disorders;   Healthy Volunteers;   Multiple Sclerosis
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 11, 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting - verified April 2017

Functional Connectivity In Relation To Proprioception and Sensorimotor Recovery in Stroke Patients (Feasibility Study)

Condition:   Stroke
Interventions:   Device: 3T scanner;   Device: Inactive transcutaneous electrical nerve stimulation (TENS);   Other: The exercises with the robot
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Recruiting - verified April 2017

Multicenter Trial of the Effect of AAT on Islet Transplant Engraftment and Durability After Renal Transplant

Conditions:   Kidney Transplant;   Type 1 Diabetes
Interventions:   Drug: Alpha 1-Antitrypsin;   Procedure: Islet Transplantation;   Drug: Thymoglobulin;   Drug: Basiliximab;   Drug: Etanercept
Sponsors:   Massachusetts General Hospital;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   University of Iowa
Recruiting - verified April 2017

HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)

Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Drug: Darunavir;   Drug: Ritonavir;   Drug: Raltegravir;   Drug: Zidovudine
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified February 1, 2017

Phase I Clinical Safety Study About Human Umbilical Cord Blood Monocyte in the Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke
Intervention:   Other: Human Umbilical Cord Blood mononuclear cells and 20% mannitol
Sponsors:   China Medical University Hospital;   StemCyte, Inc.;   University of South Florida;   Saneron CCEL Therapeutics, Inc.;   Buddhist Tzu Chi General Hospital
Recruiting - verified April 2017

Inflammatory and Infectious Diseases of the Nervous System

Condition:   Brain Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 22, 2017

Oral Guanabenz for Multiple Sclerosis

Conditions:   Multiple Sclerosis, Relapsing-Remitting;   Multiple Sclerosis
Intervention:   Drug: Guanabenz
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 14, 2017

Feasibility Study of Deep Brain Recordings for Learning and Memory

Condition:   Movement Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Withdrawn - verified October 23, 2015

Muscle Ultrasound Measures as Biomarkers of Upper Motor Neuron Function

Condition:   Muscle Spasticity
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified August 3, 2015

A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart

Condition:   Acute Coronary Syndromes
Interventions:   Drug: Apixaban;   Drug: vitamin K antagonist;   Drug: Acetylsalicylic acid;   Other: Acetylsalicylic acid placebo
Sponsors:   Bristol-Myers Squibb;   Pfizer;   Duke Clinical Research Institute
Recruiting - verified April 2017

SONOlysis in Prevention of Brain InfaRctions During Internal Carotid Endarterectomy

Condition:   Internal Carotid Artery Stenosis
Intervention:   Device: sonolysis
Sponsors:   University Hospital Ostrava;   Military University Hospital, Prague;   Vitkovice Hospital, Ostrava;   Masaryk Hospital Usti nad Labem;   České Budějovice Hospital;   University Hospital Hradec Kralove;   University Hospital Pilsen;   County Hospital Liberec, Liberec;   University Hospital, Martin;   Jihlava Hospital, Jihlava;   Na Homolce Hospital;   University Hospital, Motol;   Faculty Hospital Nitra;   University Hospital Olomouc;   University Hospital Kosice;   Tomas Bata Hospital, Czech Republic
Recruiting - verified April 2017

Neuroprotection in Patients Undergoing Aortic Valve Replacement

Conditions:   Aortic Stenosis;   Brain Infarction;   Cerebrovascular Accident;   Stroke
Interventions:   Device: Embol-X Embolic Protection Device;   Device: CardioGard Cannula
Sponsors:   Icahn School of Medicine at Mount Sinai;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2017

Influence on Plasticity of Brain Temperature

Condition:   Healthly Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 12, 2017

Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy

Conditions:   Giant Axonal Neuropathy;   Gene Transfer
Intervention:   Drug: Intrathecal Delivery of scAAV9/JeT-GAN
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 28, 2017

Physiological and Psychosomatic Effects of Exposure to MRI Scanning Environment

Condition:   Healthy Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified October 12, 2016

Role of PPAR-y Agonists in Immunomodulation and Vascular Prevention in SLE (PPAR-SLE)

Condition:   Systemic Lupus Erthematosus
Interventions:   Radiation: PET/CT;   Drug: Pioglitazone;   Procedure: Vascular function studies
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified November 21, 2016

Comparison of Electrophysiologic and Ultrasound Guidance for Onabotulinum Toxin A Injections in Focal Upper Extremity Dystonia and Spasticity

Conditions:   Dystonia;   Focal Dystonia;   Musician's Dystonia;   Muscle Spasticity
Interventions:   Procedure: BoNT injection;   Procedure: US guidance;   Procedure: E-stim Guidance
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 8, 2017

Left Internal Thoracic Artery Bypass Versus Percutaneous Revascularization in Diabetics

Conditions:   Coronary Artery Disease;   Diabetes Mellitus
Interventions:   Procedure: Minimally Invasive Coronary Bypass;   Procedure: Percutenous Coronary Intervention
Sponsors:   Ottawa Heart Institute Research Corporation;   University of Toronto
Not yet recruiting - verified April 2017

Virtual Reality Exercise for Stroke Rehabilitation in Inpatients Who Are Unable to Stand

Condition:   Stroke
Interventions:   Other: virtual reality training;   Other: control
Sponsors:   Bruyere Research Institute;   Ottawa Hospital Research Institute;   University of Ottawa;   Heart and Stroke Foundation of Canada
Completed - verified April 2017

Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID)-2.0

Condition:   Hypertension
Intervention:  
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   National Human Genome Research Institute (NHGRI)
Active, not recruiting - verified January 24, 2017

REACH OUT: to Reduce High Blood Pressure in the Emergency Department

Conditions:   Hypertension;   Stroke
Intervention:   Behavioral: Text messaging
Sponsor:   University of Michigan
Completed - verified April 2017

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified April 2017

Thrombolysis in Ischemic Spinal Cord Stroke

Conditions:   Motor Weakness in Two or Four Limbs;   Damage in the Anterior Spinal Artery (ASA);   Temperature and Superficial Sensation;   Urinary Retention or Bowel Disorder
Intervention:   Drug: Intravenuse Alteplase
Sponsor:   Rabin Medical Center
Active, not recruiting - verified April 2017

Early Rheumatoid Arthritis COR Intervention

Conditions:   Rheumatoid Arthritis;   Cardiovascular Diseases
Interventions:   Other: Simvastatin;   Other: Losartan;   Other: Losartan;   Other: Losartan;   Other: Metformin;   Other: Outpatient rheumatology department;   Other: Refered to general practice
Sponsor:   MD, PhD, Annemarie Lyng Svensson
Recruiting - verified April 2017

Systematic Evaluation of Patients Treated With Stroke Devices for Acute Ischemic Stroke (STRATIS) Registry

Condition:   Ischemic Stroke
Intervention:  
Sponsor:   Medtronic Neurovascular Clinical Affairs
Active, not recruiting - verified April 2017

Antiplatelet Therapy for Patients Undergoing Transcatheter Aortic Valve Implantation

Conditions:   Aortic Valve Disease;   Myocardial Infarction;   Stroke;   Bleeding
Interventions:   Drug: Aspirin + clopidogrel;   Drug: Aspirin monotherapy;   Drug: OAC + clopicogrel;   Drug: OAC monotherapy
Sponsor:   St. Antonius Hospital
Recruiting - verified April 2017

The CREST-2 Registry

Condition:   Carotid Artery Diseases
Intervention:   Device: Carotid Artery Stent
Sponsors:   University of Maryland;   National Institute of Neurological Disorders and Stroke (NINDS);   Centers for Medicare and Medicaid Services;   Mayo Clinic;   Society for Vascular Surgery;   American College of Cardiology
Recruiting - verified April 2017

CARDIOBASE Bern PCI Registry

Condition:   Myocardial Ischemia
Intervention:   Procedure: Percutaneous coronary intervention
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified April 2017

Effect of Recombinant Erythropoietin on Numbers of Circulating Endothelial Progenitor Cells in People With Persistent Symptoms During the Subacute Period After Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Intervention:   Drug: Erythropoeitin
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 12, 2016

Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI

Conditions:   Cognition Disorder;   Attention Deficit Disorder;   Traumatic Brain Injury
Intervention:   Drug: Methylphenidate
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Suspended - verified October 12, 2016

Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Aphasia

Condition:   Aphasia
Interventions:   Device: transcranial direct current stimulation;   Other: Non-Prime Condition;   Behavioral: Traditional behavioral treatment
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Recruiting - verified April 2017

Feasibility of Endovascular Repair Of Ascending Aortic Pathologies

Conditions:   Aortic Dissection;   Intramural Hematoma;   Penetrating Ulcer;   Pseudoaneurysm
Intervention:   Device: Endovascular repair with Valiant PS-IDE Stent Graft
Sponsor:   Rodney A. White, M.D.
Recruiting - verified April 2017

Optimal Anticoagulation for Higher Risk Patients Post-Catheter Ablation for Atrial Fibrillation Trial

Conditions:   Atrial Fibrillation;   Stroke
Interventions:   Drug: Rivaroxaban;   Drug: Acetylsalicylic acid
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research (CIHR);   Bayer;   Biotronik SE & Co. KG
Recruiting - verified April 2017

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease, on Dialysis

Condition:   Anemia
Interventions:   Drug: Roxadustat;   Drug: Epoetin alfa
Sponsors:   AstraZeneca;   FibroGen
Recruiting - verified April 2017

Neural Basis of Decision-Making Deficits in Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Uniformed Services University of the Health Sciences
Recruiting - verified March 2, 2017

Apixaban During Atrial Fibrillation Catheter Ablation: Comparison to Vitamin K Antagonist Therapy

Condition:   Atrial Fibrillation
Interventions:   Drug: Vitamin K antagonist;   Drug: Apixaban
Sponsors:   German Atrial Fibrillation Network;   Bristol-Myers Squibb;   Pfizer;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)
Active, not recruiting - verified April 2017

Clinical Autonomic Disorders: A Training Protocol

Conditions:   Chronic Fatigue Syndrome;   Pseudopheochromocytoma;   Healthy Volunteers;   Neurocardiogenic Syncope;   Postural Tachycardia Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 12, 2016

Peripheral Sensory Input in Central Post Stroke Pain (CPSP)

Condition:   Central Post Stroke Pain
Intervention:   Drug: Ultrasound-guided peripheral nerve block with 2% lidocaine
Sponsors:   Washington University School of Medicine;   Aarhus University Hospital
Completed - verified April 2017

Rehabilitating Corticospinal Control of Walking

Condition:   Stroke
Interventions:   Behavioral: ACC training;   Behavioral: SS training
Sponsors:   VA Office of Research and Development;   University of Florida;   Brooks Center for Rehabilitation Studies
Recruiting - verified April 2017

Study of Hepatic Function in Patients With Spinal and Bulbar Muscular Atrophy

Conditions:   Liver;   Motor Neuron Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 3, 2017

A Blinded Study to Evaluate Effect on Atrial Fibrillation Burden in Patients With Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Interventions:   Drug: BMS-919373;   Drug: Placebo (Matching with BMS-919373)
Sponsor:   Bristol-Myers Squibb
Completed - verified June 2016

Deep Brain Stimulation Therapy in Movement Disorders

Conditions:   Parkinson's Disease;   Movement Disorders;   Deep Brain Stimulation;   Dystonia;   Essential Tremor
Intervention:   Other: Deep Brain Stimulation Management
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 9, 2017

Effect of Vorinostat on Nervous System Hemangioblastomas in Von Hippel-Lindau Disease (Missense Mutation Only)

Condition:   Von Hippel-Lindau Disease
Intervention:   Drug: Vorinostat
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified December 5, 2016

Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy

Condition:   Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 6, 2016

Depotentiation in People With Focal Hand Dystonia

Conditions:   Focal Dystonia;   Healthy Volunteers
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Prachaya Srivanitchapoom, MD
Recruiting - verified October 12, 2016

Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes

Condition:   Diabetes Type 2
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified July 22, 2016

A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients

Conditions:   Heart Failure;   Respiratory Insufficiency;   Stroke Acute;   Infectious Diseases;   Rheumatic Diseases
Interventions:   Drug: Rivaroxaban, 10 mg;   Drug: Rivaroxaban, 7.5 mg;   Drug: Placebo
Sponsors:   Janssen Research & Development, LLC;   Bayer
Recruiting - verified April 2017

fMRI Neurofeedback for Motor Rehabilitation

Conditions:   Stroke;   fMRI
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 11, 2016

Elite Controller and ART-treated HIV+ Statin Versus ASA Treatment Intervention Study

Condition:   HIV Infection
Interventions:   Drug: Aspirin 81 mg daily;   Drug: Atorvastatin 40 mg daily
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified July 29, 2016

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Conditions:   Hypertension;   Cardiovascular Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting - verified January 6, 2017

Study of Pain Processing in Experienced Yoga Practitioners

Condition:   Pain
Intervention:  
Sponsors:   National Center for Complementary and Integrative Health (NCCIH);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Nursing Research (NINR)
Completed - verified October 12, 2016

Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency

Conditions:   Metabolic Disease;   Seizures
Interventions:   Drug: SGS-742;   Drug: Placebo
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 28, 2017

Influence of Stroke on the Composition of Intestinal Microbiota

Conditions:   Stroke;   Transient Ischemic Attack (TIA)
Intervention:  
Sponsors:   Charite University, Berlin, Germany;   Prof. Dr. Ulrich Dirnagl, Experimental Neurology, Charité Berlin, Germany;   Dr. Christian Meisel, Medical Immunology, Charité Berlin, Germany;   PD Dr. Andreas Nitsche, Robert-Koch-Institut, Berlin, Germany
Recruiting - verified April 2017

Development of Walk Assist Device to Improve Community Ambulation

Condition:   Stroke
Interventions:   Device: The Stride Management Assist (SMA) System;   Other: Impairment based therapy
Sponsors:   Rehabilitation Institute of Chicago;   Honda
Active, not recruiting - verified April 2017

Power Training Post-stroke

Condition:   Stroke
Intervention:   Behavioral: POWER training
Sponsor:   VA Office of Research and Development
Recruiting - verified April 2017

Functional Brain Imaging in Healthy Volunteers to Study Cognitive Functions

Condition:   Healthy Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 11, 2016

Effects of Exercise on Memory in Healthy and Brain-Injured Individuals

Condition:   Traumatic Brain Injury
Interventions:   Other: Exercise - Low-intensity exercise;   Other: Exercise - High-intensity exercise
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified May 21, 2015

Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation

Conditions:   Amyotrophic Lateral Sclerosis;   Frontotemporal Lobar Degeneration
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Aging (NIA)
Recruiting - verified March 16, 2017

A Study of Movement Disorders Using the QMAT At-Home Testing Device

Conditions:   Movement Disorders;   Parkinson's Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified April 15, 2015

HCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Intervention:   Other: None - this is an observational study
Sponsors:   University of Virginia;   National Heart, Lung, and Blood Institute (NHLBI);   Oxford University Hospitals NHS Trust
Active, not recruiting - verified April 2017

Electrical Impedance Myography: Exploratory Studies in Healthy People and People With Neuromuscular Disorders

Conditions:   Neuromuscular Disease;   Motor Neuron Disease;   Inherited Neuromuscular Conditions;   Inherited Neuropathies
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 16, 2017

Resolute Integrity US Extended Length Sub-Study(RI-US XL)

Condition:   Coronary Artery Disease
Intervention:   Device: Resolute Integrity Stent
Sponsor:   Medtronic Vascular
Active, not recruiting - verified April 2017

Effects of Training in a Virtual Environment in Chronic Stroke Patients

Condition:   Stroke
Interventions:   Other: Virtual Reality Training;   Other: Physical Therapy
Sponsor:   University of Sao Paulo General Hospital
Recruiting - verified April 2017

The Effects of Repetitive Paired Associative Stimulation in Dystonia

Condition:   Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified August 2, 2016

Thinking and Memory Problems in People With HIV

Conditions:   Acquired Immunodeficiency;   Neurocognitive Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 11, 2017

Pilot Study of Ultrasonic Determined Carotid Plaque Composition

Condition:   Atherosclerosis
Intervention:   Device: Research Ultrasound Exam
Sponsors:   D. Geoffrey Vince;   Siemens Medical Solutions
Enrolling by invitation - verified April 2017

Imaging Studies of Cognitive Impairment in Parkinson s Disease

Conditions:   Parkinson Disease;   Dementia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified February 3, 2015

Cerebrospinal Fluid Collection and Repository Storage

Condition:   Neurological Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 15, 2017

Raltegravir for HAM/TSP

Condition:   HTLV-I Infection
Intervention:   Drug: Raltegravir
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 12, 2016

Idebenone for Primary Progressive Multiple Sclerosis

Conditions:   Multiple Sclerosis;   Primary Progressive Multiple Sclerosis
Intervention:   Drug: Idebenone
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified April 10, 2017

Exercise Education for Adults With Seizure Disorders

Conditions:   Seizures;   Epilepsy
Interventions:   Other: Patient Education;   Other: exercise: increase physical activity/goal setting
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified January 25, 2017

Study Of Diabetic Nephropathy With Atrasentan

Condition:   Diabetic Nephropathy
Interventions:   Drug: Atrasentan;   Drug: Placebo
Sponsor:   AbbVie
Recruiting - verified April 2017

Natural History of Optic Neuritis

Condition:   Multiple Sclerosis
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS);   National Eye Institute (NEI)
Suspended - verified December 8, 2016

Skeletal Muscle Biomarkers in People With Fragile Sarcolemmal Muscular Dystrophy

Condition:   Genetic Disorder
Intervention:  
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institutes of Health Clinical Center (CC);   University of Massachusetts, Worcester
Recruiting - verified March 22, 2017

Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III

Condition:   Intracerebral Hemorrhage
Intervention:   Drug: rt-PA
Sponsors:   Johns Hopkins University;   National Institute of Neurological Disorders and Stroke (NINDS);   Genentech, Inc.;   Emissary International LLC
Recruiting - verified April 2017

Pivotal Study of the FRED Stent System in the Treatment of Intracranial Aneurysms

Condition:   Intracranial Aneurysms
Intervention:   Device: Flow Re-Direction Endoluminal Device
Sponsor:   Microvention-Terumo, Inc.
Active, not recruiting - verified September 2016

Deep Brain Stimulation for Refractory Alcoholism

Condition:   Alcoholism
Intervention:   Procedure: Implantation of Deep Brain Stimulation
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Withdrawn - verified November 13, 2015

Transcranial Magnetic Stimulation for Focal Hand Dystonia

Condition:   Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 11, 2016

Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis

Conditions:   Cryptococcal Meningitis;   Fungal Meningitis
Intervention:   Drug: Sertraline
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Infectious Disease Institute, Kampala, Uganda;   National Institute of Neurological Disorders and Stroke (NINDS);   Mbarara University of Science and Technology;   Medical Research Council;   Wellcome Trust;   Makerere University
Recruiting - verified April 2017

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention &Amp; Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute;   Janssen Research & Development, LLC
Active, not recruiting - verified April 2017

Treatment of Functional Movement Disorders With Psychotherapy

Condition:   Movement Disorders
Interventions:   Other: Group Psychotherapy;   Other: Cognitive behavior therapy based on self help
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified July 23, 2015

The Reus-Tarragona Birth Cohort Study of Early Development and Ageing.

Condition:   Intrauterine Development
Intervention:   Other: Observational
Sponsors:   Institut Investigacio Sanitaria Pere Virgili;   Italfarmaco;   Instituto de Salud Carlos III;   CIBERobn
Recruiting - verified April 2017

Effects of Transcranial Magnetic Stimulation on Object Recognition

Conditions:   Repetitive TMS (rTMS);   Sham rTMS;   Bilateral rTMS;   Unilateral rTMS
Interventions:   Procedure: Sham rTMS;   Procedure: Bilateral rTMS at same frequency and in phase;   Procedure: Bilateral rTMS at different frequencies;   Procedure: Bilateral rTMSat same frequency and out of phase;   Procedure: rTMS over TP8;   Procedure: rTMS over TP7
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified January 26, 2017

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)

Condition:   Progressive Multifocal Leukoencephalopathy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 13, 2017

Safety of Platelet Transfusion in Patients on Antiplatelet Therapy With Traumatic Head Injury

Conditions:   Traumatic Head Injury;   Intracranial Hemmorhage;   Anti-platelet Therapy
Interventions:   Other: Saline;   Other: Platelets
Sponsors:   Christiana Care Health Services;   United States Department of Defense
Terminated - verified April 2017

Pelvic Obliquity Rehabilitation in Stroke Patients Using Robotically Generated Force Fields

Conditions:   Gait Re-training in Healthy Subjects;   Gait Re-training in Stroke Survivors
Intervention:   Device: Robotic Gait Rehabilitation (RGR) Trainer
Sponsors:   Spaulding Rehabilitation Hospital;   Northeastern University
Active, not recruiting - verified April 2017

Improving Recovery After Stroke Via Electrical Stimulation of Proprioceptors

Condition:   Chronic Stroke Survivors
Intervention:   Device: Current stimulator
Sponsors:   Spaulding Rehabilitation Hospital;   Wyss Institute at Harvard University;   Center for Integration of Medicine & Innovative Technology
Terminated - verified April 2017

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2017

Strategy of Continued Versus Interrupted Novel Oral Anti-coagulant at Time of Device Surgery in Patients With Moderate to High Risk of Arterial Thromboembolic Events

Condition:   Hematoma
Interventions:   Drug: Dabigatran;   Drug: Rivaroxaban;   Drug: Apixaban
Sponsors:   Ottawa Heart Institute Research Corporation;   Boehringer Ingelheim;   Heart and Stroke Foundation of Canada;   Bayer;   Bristol-Myers Squibb
Recruiting - verified April 2017

Brain P-gp and Inflammation in People With Epilepsy

Condition:   Epilepsies, Partial
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 3, 2017

The Efficacy and Economics of Exercise Maintenance Post-Cardiac Rehabilitation

Condition:   Coronary Artery Disease
Intervention:   Behavioral: Exercise Facilitator Intervention
Sponsors:   Ottawa Heart Institute Research Corporation;   Heart and Stroke Foundation of Ontario
Active, not recruiting - verified January 2017

AAV2-GDNF for Advanced Parkinson s Disease

Condition:   Parkinson's Disease
Intervention:   Genetic: Convection enhanced delivery/AAV2-GDNF
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 13, 2017

Evaluating New Radiation Techniques for Cardiovascular Imaging

Condition:   Coronary Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 23, 2017

Relating Genetic and Environmental Risk Scores to Multiple Sclerosis Susceptibility

Condition:   Multiple Sclerosis
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 13, 2016

Dabigatran Versus Warfarin Anticoagulation Before and After Catheter Ablation for the Treatment of Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:  
Sponsors:   William Beaumont Hospitals;   University of Pennsylvania;   Johns Hopkins University;   London Health Sciences Centre
Withdrawn - verified December 2016

Taurine Therapy for SSADH Deficiency

Condition:   Succinic Semialdehyde Dehydrogenase
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified December 16, 2013

Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI).

Condition:   Severe Aortic Stenosis
Interventions:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI);   Procedure: Surgical Aortic Valve Replacement (SAVR) (Not applicable for Single Arm);   Device: Medtronic CoreValve® Evolut R System Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Medtronic Cardiovascular
Recruiting - verified April 2017

Deep Brain Stimulation Surgery for Movement Disorders

Conditions:   Parkinson's Disease;   Essential Tremor;   Dystonia
Intervention:   Procedure: Deep Brain Stimulation
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 5, 2016

Neuroimmunology Branch Repository

Conditions:   HTLV-1 Infection;   Multiple Sclerosis;   Neurologic Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified January 10, 2017

Validating a New Writer s Cramp Scale

Condition:   Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified October 25, 2016

Genetic and Physical Study of Childhood Nerve and Muscle Disorders

Conditions:   Muscular Dystrophies;   Muscle Myopathies;   Hereditary Spastic Paraplegias;   Inherited Neuropathies;   Inherited Neuromuscular Conditions
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 16, 2017

Botulinum Toxin for Pelvic Pain in Women With Endometriosis

Conditions:   Endometriosis;   Botulinum Toxin A;   Chronic Pelvic Pain;   Pelvic Muscle Spasms;   Quality of Life
Intervention:   Drug: Botuninum toxin A
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 22, 2017

Infants With Spinal Muscular Atrophy Type I

Condition:   Spinal Muscular Atrophy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified April 14, 2016

The Effects of Chronic Exposure to Low-Level Blasts

Condition:   Tramatic Brain Injury
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Walter Reed Army Institute of Research (WRAIR);   Naval Medical Research Center
Recruiting - verified October 11, 2016

Studying Motor Neuron Tests

Conditions:   Magnetic Resonance Imaging;   Central Nervous System;   Volunteer;   Neurological Disorder
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 15, 2016

Buspirone Therapy for Localized Epilepsy

Conditions:   Anxiety Disorder;   Seizures;   Epilepsy;   Partial Epilepsy;   Depression
Intervention:   Drug: Buspirone
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified April 19, 2016

Imaging Biomarkers in Parkinson s Disease

Condition:   Parkinson Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 28, 2017

Service Member Fatigue and Lack of Motivation Following Concussion

Conditions:   Fatigue;   Traumatic Brain Injury
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified August 3, 2015

Combined Deep Brain Stimulation for Parkinson's Disease

Condition:   Parkinson Disease
Intervention:   Procedure: DBS Surgery
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Withdrawn - verified July 30, 2014

Analysis of Visual-Motor Task Electrophysiological Activity During Deep Brain Stimulation for Treatment-Resistant Movement Disorders

Condition:   Obsessive-Complusive Disorder
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   George Washington University
Recruiting - verified March 16, 2017

Bioavailability and Biological Effects of Vitamin D2 Contained in Mushroom

Conditions:   Vitamin D Deficiency;   Metabolic Syndrome;   Prediabetes
Interventions:   Dietary Supplement: Mushroom with 600 IU vitamin D2;   Dietary Supplement: Mushroom with 4000 IU Vitamin D2;   Dietary Supplement: 600 IU Vitamin D3 and untreated mushroom;   Dietary Supplement: 4000 IU Vitamin D3 and untreated mushroom;   Drug: Placebo
Sponsor:   Icahn School of Medicine at Mount Sinai
Completed - verified April 2017

Octanoic Acid for Essential Tremor

Condition:   Essential Tremor
Intervention:   Drug: Octanoic Acid
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified July 18, 2012

Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD)

Condition:   Sickle Cell Disease
Interventions:   Procedure: Allogeneic Non-Myeloablative Stem Cell Transplantation;   Drug: Alemtuzumab;   Drug: Sirolimus
Sponsor:   University of Illinois at Chicago
Recruiting - verified April 2017

Effects of Hormone Stimulation on Brain Scans for Cushing s Disease

Condition:   Pituitary Neoplasm
Intervention:   Drug: Acthrel
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 11, 2017

Studying Skeletal Muscle, Heart, and Diaphragm Imaging in Boys With Duchenne Muscular Dystrophy

Conditions:   Muscular Dystrophy;   Muscular Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified May 4, 2016

Mood and Insulin Resistance in Adolescents At-Risk for Diabetes

Conditions:   Depression;   Impaired Glucose Tolerance
Interventions:   Other: The Blues Program;   Other: Hey Durham
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   National Institutes of Health Clinical Center (CC)
Completed - verified January 27, 2016

Hyper-CVAD and Ponatinib in Ph-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia (ALL)

Condition:   Leukemia
Interventions:   Drug: Cyclophosphamide;   Drug: Mesna;   Drug: Doxorubicin;   Drug: Vincristine;   Drug: Dexamethasone;   Drug: Ponatinib;   Drug: G-CSF (Filgrastim);   Drug: Rituximab;   Drug: Methotrexate;   Drug: Cytarabine;   Drug: Solu-medrol ( Methyl Prednisolone);   Drug: Citrovorum (Leucovorin);   Drug: Prednisone;   Drug: Pegfilgrastim (Neulasta)
Sponsors:   M.D. Anderson Cancer Center;   Ariad Pharmaceuticals
Recruiting - verified April 2017

Mifepristone for Metabolic Syndrome

Conditions:   Endocrine Disease;   Diabetes
Intervention:   Drug: Mifepristone
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified December 16, 2016

Bevacizumab With or Without Surgery for Adult Glioblastomas

Conditions:   Glioblastoma;   Brain Neoplasm
Intervention:   Procedure: Craniotomy
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Withdrawn - verified September 26, 2013

ASP (PPI_H2RA) Study-H2RA Versus PPI for the Prevention of Recurrent UGIB in High-risk Users of Low-dose ASA

Condition:   Upper Gastrointestinal Bleeding
Interventions:   Drug: Rabeprazole;   Drug: Famotidine
Sponsor:   Chinese University of Hong Kong
Completed - verified April 2017

Testing Devices That Involve the Sense of Touch in Subjects With Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Intervention:  
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed - verified February 6, 2015

Reducing Cardiovascular Disease by Combining Smoking Cessation Pharmacotherapy and Behavioural Counseling

Conditions:   Smoking Cessation;   Psychiatric Illness
Interventions:   Drug: Champix;   Drug: Transdermal Nicoderm patch combined with gum or inhaler;   Drug: Transdermal Nicoderm patch
Sponsors:   Ottawa Heart Institute Research Corporation;   Heart and Stroke Foundation of Ontario
Completed - verified April 2017

Brain Areas Involved in Sound and Spoken Word Memory

Conditions:   Brain Mapping;   Language Disorder;   Adult;   Healthy;   Memory Disorder
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified October 30, 2015

Effect of Functional Exercise in Patients With Spinal Bulbar Muscular Atrophy

Condition:   Motor Neuron Disease
Interventions:   Behavioral: A functional exercise program;   Behavioral: A stretching exercise program
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified March 6, 2017

Asymptomatic Carotid Stenosis: Cognitive Function and Plaque Correlates

Condition:   Cognitive Manifestations
Intervention:  
Sponsors:   VA Office of Research and Development;   George Mason University
Active, not recruiting - verified April 2017

Manganese-Enhanced Magnetic Resonance Imaging in Healthy Volunteers and People With Multiple Sclerosis

Conditions:   Multiple Sclerosis;   Optic Neuritis
Intervention:   Drug: Mangafodipir (Teslascan)
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 11, 2016

The Relationship Between Uric Acid and Inflammatory Markers

Condition:   Healthy Volunteers
Interventions:   Drug: IV Uric Acid;   Drug: IV Rasburicase
Sponsor:   National Institute on Aging (NIA)
Completed - verified January 31, 2014

Structural and Functional Neuroimaging Studies of Combat Veterans

Conditions:   Traumatic Brain Injury;   PTSD
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Center for Neuroscience and Regenerative Medicine (CNRM)
Completed - verified February 3, 2014

Plethysmography Variability Index as an Indicator of Adequacy of Preload

Condition:   Gynecological Surgery
Intervention:  
Sponsor:   University of Louisville
Suspended - verified April 2017

Evaluation and Diagnosis of Potential Research Subjects With Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Intervention:  
Sponsors:   National Institute of Nursing Research (NINR);   National Institute of Neurological Disorders and Stroke (NINDS);   Center for Neuroscience and Regenerative Medicine (CNRM)
Recruiting - verified April 10, 2017

PRX-00023 Therapy in Localization-Related Epilepsy

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Partial Epilepsy
Intervention:   Drug: PRX-00023
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified April 6, 2017

Surgery as a Treatment for Medically Intractable Epilepsy

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Partial Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 11, 2016

Prevention of Recurrent Ulcer Bleeding in High-risk Aspirin Users Who Are Not Infected With Helicobacter Pylori

Condition:   Ulcer Bleeding
Intervention:  
Sponsor:   Chinese University of Hong Kong
Completed - verified April 2017

National Epidemiologic Survey on Alcohol and Related Conditions-III

Condition:   Alcohol-Related Disorders
Intervention:  
Sponsor:   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Completed - verified October 3, 2016

The Effect of Transcranial Magnetic Stimulation on Learning With Reward in Healthy Humans

Conditions:   Normal Physiology;   fMRI
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 11, 2016

Mobility Training to Improve Motor Behavior in Toddlers With or at Risk for Cerebral Palsy: A Pilot Study

Conditions:   Developmental Delay;   Cerebral Palsy
Intervention:   Behavioral: mobility training with dynamic body weight support
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed - verified April 14, 2016

CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: linagliptin;   Drug: glimepiride;   Drug: linagliptin placebo;   Drug: glimepride placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting - verified April 2017

Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease

Conditions:   TIA;   Stroke;   Carotid Artery Stenosis
Intervention:   Radiation: PET/CT imaging with F-18 fluorodeoxyglucose
Sponsors:   Ottawa Heart Institute Research Corporation;   The Ottawa Hospital
Terminated - verified April 2017

RESOLUTE China Registry:

Conditions:   Ischemic Heart Disease;   Stenotic Coronary Lesion;   Cardiovascular Diseases;   Arteriosclerosis;   Coronary Artery Disease
Intervention:  
Sponsor:   Medtronic Vascular
Active, not recruiting - verified April 2017

Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients

Conditions:   Neoplasms;   Nervous System Disease;   Vestibular Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified June 3, 2015

Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression

Conditions:   Atherosclerosis;   Hypercholesterolemia
Interventions:   Drug: Statin Drugs;   Other: HMG-CoA Reductase Inhibitors
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed - verified February 22, 2017

Ethanol Response in Essential Tremor: Clinical and Neurophysiological Correlates

Condition:   Essential Tremor
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified January 4, 2017

Neural Dynamics and Connectivity in Response Inhibition and Traumatic Brain Injury

Conditions:   Traumatic Brain Injury;   Stroke;   Headache;   PTSD
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   United States Department of Defense;   Center for Neuroscience and Regenerative Medicine (CNRM);   National Institutes of Health Clinical Center (CC)
Recruiting - verified November 21, 2016

Effects of Rapid-Resisted Exercise and Bright Light Therapy on Ambulatory Adults With Traumatic Brain Injury

Conditions:   Adult;   Traumatic Brain Injury;   fMRI
Interventions:   Other: Exercise;   Other: Mood Therapy
Sponsors:   National Institutes of Health Clinical Center (CC);   Center for Neuroscience and Regenerative Medicine (CNRM);   Henry M. Jackson Foundation for the Advancement of Military Medicine;   United States Department of Defense
Completed - verified December 28, 2016

A Prospective Natural History Study of Patients With Syringomyelia

Conditions:   Syringomyelia;   Arnold Chiari Deformity
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified November 7, 2016

Investigating Mechanism of Action of DAC HYP in the Treatment of High-Inflammatory Multiple Sclerosis (MS)

Conditions:   Multiple Sclerosis;   Multiple Sclerosis, Relapsing-Remitting
Intervention:   Biological: DAC-HYP
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified October 11, 2016

Oxidative Stress in Motor Neuron Disease: COSMOS Add-On Study

Conditions:   Motor Neuron Disease;   Primary Lateral Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified August 3, 2015

Evaluation, Pathogenesis, and Outcome of Subjects With or Suspected Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Center for Neuroscience and Regenerative Medicine (CNRM);   United States Department of Defense;   Henry M. Jackson Foundation for the Advancement of Military Medicine
Recruiting - verified February 17, 2017

Genetics of Motor Learning

Conditions:   Parkinson s Disease;   Dystonic Disorders;   Focal Dystonia;   Movement Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified December 21, 2015

Top-Down Attentional Control of Visual-Processing

Conditions:   Focal Brain Lesion;   Focal Lesions;   fMRI
Intervention:  
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting - verified June 30, 2016

The Influence of Sensory Stimuli on Gait Imagery in Patients With Freezing of Gait

Condition:   Parkinson Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified January 3, 2014

SMN Copy Number Distribution in Mali, West Africa

Condition:   Spinal Muscular Atrophy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified May 31, 2016

Improving the Results of Heart Bypass Surgery Using New Approaches to Surgery and Medication

Condition:   Coronary Artery Disease
Interventions:   Procedure: No-touch SVG harvest vs conventional SVG harvest technique;   Dietary Supplement: Fish oil supplementation vs placebo
Sponsors:   Sunnybrook Health Sciences Centre;   Hamilton Health Sciences Corporation
Active, not recruiting - verified April 2017

Cerebral Activity Related to Primary Motor Stereotypies in Children: An EEG Study.

Condition:   Movement Disorder
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified June 29, 2012

CANVAS - CANagliflozin cardioVascular Assessment Study

Conditions:   Diabetes Mellitus, Type 2;   Cardiovascular Diseases;   Risk Factors
Interventions:   Drug: Canagliflozin (JNJ-28431754);   Drug: Placebo
Sponsors:   Janssen Research & Development, LLC;   The George Institute for Global Health, Australia
Completed - verified April 2017

Screening Protocol for Patients With Stroke

Condition:   Stroke
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 16, 2017

Physiological Investigations of Movement Disorders

Conditions:   Parkinson's Disease;   Tourette's Syndrome;   Tic Disorders;   Dystonia;   Movement Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Suspended - verified January 11, 2017

Recording and Modulation of Neuronal Mechanisms During Operant Conditioning: a MEG Study

Condition:   Central Nervous System
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified May 31, 2016

Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors

Conditions:   Adult Central Nervous System Germ Cell Tumor;   Adult Ependymoblastoma;   Adult Medulloblastoma;   Adult Pineoblastoma;   Adult Supratentorial Primitive Neuroectodermal Tumor;   Childhood Atypical Teratoid/Rhabdoid Tumor;   Childhood Central Nervous System Germ Cell Tumor;   Childhood Ependymoblastoma;   Medulloepithelioma;   Ototoxicity;   Recurrent Adult Brain Neoplasm;   Recurrent Childhood Central Nervous System Embryonal Neoplasm;   Recurrent Childhood Malignant Germ Cell Tumor;   Recurrent Childhood Medulloblastoma;   Recurrent Childhood Pineoblastoma;   Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor
Interventions:   Drug: Carboplatin;   Drug: Mannitol;   Drug: Melphalan;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Drug: Sodium Thiosulfate
Sponsors:   OHSU Knight Cancer Institute;   National Cancer Institute (NCI);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2017

Double Blind Placebo-Controlled Phase I/II Clinical Trial of Idebenone in Patients With Primary Progressive Multiple Sclerosis (IPPoMS)

Condition:   Primary Progressive Multiple Sclerosis
Intervention:   Drug: Idebenone
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified April 10, 2017

GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Depression;   Depressive Disorder, Major
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 2, 2013

Convection-Enhanced Delivery to Study the Pathophysiology Underlying the Clinical Features of Parkinson s Disease

Condition:   Parkinson's Disease
Intervention:   Drug: Muscimol
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Withdrawn - verified September 1, 2016

Effect of Reward on Learning in Motor Cortex

Condition:   Healthy
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   United States Department of Defense;   National Institutes of Health Clinical Center (CC);   Center for Neuroscience and Regenerative Medicine (CNRM)
Completed - verified January 22, 2013

Investigation of Neurofeedback With Real-Time fMRI in Healthy Volunteers and Patients With Hyperkinetic Movement Disorders

Conditions:   Movement Disorder;   Tourette Syndrome;   Healthy Volunteer
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 10, 2017

An Open Label Dose Escalation Safety Study of Convection-Enhanced Delivery of IL13-PE38QQR in Patients With Progressive Pediatric Diffuse Infiltrating Brainstem Glioma and Supratentorial High-grade Glioma

Conditions:   Brain Neoplasm;   Glioma
Intervention:   Drug: IL13-PE38QQR
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified June 5, 2015

Plaque Inflammation and Dysfunctional HDL in AIM-HIGH

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Coronary Disease;   Atherosclerosis;   Myocardial Infarction
Interventions:   Drug: Simvastatin and Extended-Release niacin;   Drug: Simvastatin
Sponsors:   University of Washington;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2017

The Effects of Exenatide (Byetta ) on Energy Expenditure and Weight Loss in Nondiabetic Obese Subjects

Conditions:   Weight Loss;   Obesity
Interventions:   Drug: Byetta (exenatide);   Behavioral: Weight loss;   Other: Metabolic Chamber;   Drug: Placebo
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed - verified September 19, 2016

fMRI of Language Recovery Following Stroke in Adults

Conditions:   Aphasia;   Stroke
Intervention:   Behavioral: CIAT
Sponsors:   University of Alabama at Birmingham;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 2017

Pilot Study of Bumetanide for Newborn Seizures

Condition:   Seizures
Interventions:   Drug: Bumetanide;   Drug: Normal Saline as Placebo
Sponsors:   Soul, Janet , M.D.;   Citizens United for Research in Epilepsy;   Harvard Catalyst- Harvard Clinical and Translational Science Center;   Translational Research Program, Boston Children's Hospital;   Charles H. Hood Foundation;   National Institute of Neurological Disorders and Stroke (NINDS);   Mooney Family Initiative for Translational Studies in Rare Diseases, Boston Children's Hospital
Active, not recruiting - verified April 2017

Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer

Conditions:   Pain/Cancer;   Pain, Intractable
Interventions:   Drug: (Resiniferatoxin)(RTX);   Drug: Intrathecal Resiniferatoxin
Sponsors:   National Institute of Dental and Craniofacial Research (NIDCR);   National Institute of Neurological Disorders and Stroke (NINDS);   Sorrento Therapeutics, Inc.
Suspended - verified October 11, 2016

Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System

Conditions:   Central Nervous System Disease;   Multiple Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 14, 2017

Biomarkers of Risk of Parkinson Disease

Conditions:   Parkinson Disease;   Autonomic Nervous System Diseases;   Pure Autonomic Failure
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified February 9, 2017

Blood Markers of Inflammation, Blood Clotting and Blood Vessel Function in HIV-infected Adults

Condition:   HIV
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified January 19, 2017

Role of the Sensory Experience in Generating Motor Tics in Tourette Syndrome

Conditions:   Tic Disorder;   Tourette Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified October 25, 2016

Warfighter Head Injury Study

Condition:   Head Injury
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   United States Department of Defense;   National Institutes of Health Clinical Center (CC);   Center for Neuroscience and Regenerative Medicine (CNRM)
Terminated - verified January 9, 2013

GORE® HELEX® Septal Occluder / GORE® Septal Occluder for Patent Foramen Ovale (PFO) Closure in Stroke Patients - The Gore REDUCE Clinical Study

Conditions:   Stroke;   Transient Ischemic Attack
Interventions:   Device: GORE® HELEX® Septal Occluder / GORE® Septal Occluder;   Other: Antiplatelet Medical Therapy
Sponsor:   W.L.Gore & Associates
Active, not recruiting - verified April 2017

Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia

Conditions:   Spasmodic Dysphonia;   Focal Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified September 21, 2016

Language Mapping in Patients With Epilepsy

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Partial Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 4, 2013

Neurotoxicity in Primary Central Nervous System Lymphoma (PCNSL): An International Observational Study of Cognition in Long Term Survivors

Condition:   Primary Central Nervous System Lymphoma (PCNSL)
Intervention:  
Sponsors:   OHSU Knight Cancer Institute;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified April 2017

Autoimmunity in Neurologic Complications of Celiac Disease

Condition:   Ataxia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified January 3, 2014

Lithium Treatment for Patients With Spinocerebellar Ataxia Type I

Condition:   Spinocerebellar Ataxia Type I
Intervention:   Drug: Lithium Carbonate
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified February 27, 2014

Aging, Lifestyle and Inflammation in Veterans Exercising

Conditions:   Inflammation;   Aging;   Metabolism;   Exercise
Intervention:   Behavioral: Weight loss and aerobic exercise training
Sponsors:   University of Maryland;   VA Office of Research and Development
Active, not recruiting - verified April 2017

Hepatitis C Treatment and Atherosclerosis

Conditions:   Chronic Hepatitis C;   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed - verified March 24, 2015

Genetics of Spina Bifida and Anencephaly

Conditions:   Anencephaly;   Acrania
Intervention:  
Sponsors:   Duke University;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2017

Neurobiology and Treatment of Reading Disability in NF-1

Conditions:   Neurofibromatosis Type 1;   Reading Disabilities
Interventions:   Behavioral: Tutoring Program I;   Behavioral: Tutoring Program II
Sponsors:   Vanderbilt University;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 2017

Natural History Study of Patients With Neurofibromatosis Type 2

Conditions:   Spinal Cord Disease;   Intracranial Central Nervous System Disorder;   Neurologic Disorders;   Brain Neoplasms
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified October 6, 2016

Relationship of HHV-6B Virus to Seizures and Brain Injury

Conditions:   Epilepsy;   HHV6B Infection
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified November 1, 2013

Insulin Resistance and Atherosclerosis in Women With Lupus

Conditions:   Systemic Lupus Erythematosus;   Insulin Resistance;   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Completed - verified April 29, 2016

Neurobiology of Psychogenic Movement Disorder and Non-Epileptic Seizures

Conditions:   Psycogenic Movement Disorders;   Non-epileptic Seizures
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 24, 2017

Brain Changes in Blepharospasm

Conditions:   Dystonia;   Focal Dystonia;   Cerebellar Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified June 29, 2012

Effect of Diet on Vascular Disease in Pre-Menopausal Women

Conditions:   Cardiovascular Diseases;   Vascular Disease;   Inflammation;   Insulin;   Triglycerides
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed - verified February 14, 2017

Characteristics of Parkinson s Disease Associated With the LRRK-2 Gene Mutation

Condition:   Parkinson Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified February 3, 2014

Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System

Condition:   Healthy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 16, 2017

The Role of Serotonin in Seizures

Conditions:   Epilepsy;   Seizures
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified June 5, 2015

Brain Peripheral Benzodiazepine Receptors in Patients With Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:   Radiation: [(11)C]PBR28
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 22, 2014

Spaced Versus Massed Skill Learning

Condition:   Healthy Volunteer
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified December 16, 2013

Detecting a Reward Signal in the Motor Cortex

Condition:   Healthy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified March 6, 2014

Role of Plavix in Hemorrhagic and Ischemic Complications of Catheterization.

Conditions:   Coronary Artery Disease;   Myocardial Ischemia;   Bleeding
Interventions:   Drug: clopidogrel 600 mg;   Device: arterial access sheath
Sponsor:   Beth Israel Deaconess Medical Center
Terminated - verified April 2017

Collection of Blood Samples for DNA in Motor Neuron Disease

Condition:   Motor Neuron Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified September 9, 2013

Genetic Factors in Atherosclerosis

Condition:   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Completed - verified March 21, 2013

E-Selectin Nasal Instillation to Prevent Secondary Stroke

Conditions:   Ischemic Attack, Transient;   Transient
Intervention:   Drug: Intransal instillation of E-selectin
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified March 23, 2017

Identification of Genes Expressed in Atherosclerotic Plaque

Condition:   Atherosclerosis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified November 3, 2016

Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

Condition:   HTLV-1
Intervention:   Drug: Hu MiK-Beta-1
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 14, 2017

Vision Testing in Patients With Partial Seizures Receiving Either Lyrica or Placebo

Condition:   Epilepsies, Partial
Interventions:   Drug: Lyrica (pregabalin);   Drug: placebo
Sponsor:   Pfizer
Recruiting - verified April 2017

Nutrition Intervention Trials in Linxian Follow-up Study

Conditions:   Esophageal Cancer;   Gastric Cancer
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting - verified February 13, 2017

Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study

Conditions:   Stroke;   Diabetes Mellitus;   Heart Disease;   Cancer
Intervention:  
Sponsors:   National Cancer Institute (NCI);   National Institute for Health and Welfare, Finland
Completed - verified December 9, 2016

Brain Function in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis

Condition:   Cerebral Cortex Dysfunction
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified August 3, 2015

Biomarkers in Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified February 3, 2014

Long-Term Motor Learning in Focal Hand Dystonia

Condition:   Focal Hand Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified January 6, 2014

Long-Term Improvement in Motor Learning by Transcranial Direct Current Stimulation

Condition:   Healthy Volunteers
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   United States Department of Defense;   Center for Neuroscience and Regenerative Medicine (CNRM);   National Institutes of Health Clinical Center (CC)
Completed - verified December 16, 2013

Diffusion Tensor MRI to Distinguish Brain Tumor Recurrence From Radiation Necrosis

Conditions:   Glioma Tumor Recurrence;   Radiation Necrosis;   Primary Brain Tumor
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified August 20, 2013

Reference Values for Plasma Catechols

Conditions:   Healthy Volunteers;   Normal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 6, 2016

Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia

Conditions:   Sickle Cell Disease;   Chronic Kidney Disease;   Pulmonary Hypertension
Intervention:   Drug: Erythropoietin and Hydroxyurea
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 27, 2016

Moving a Paralyzed Hand Through Use of a Brain-Computer Interface

Condition:   Stroke
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Center for Neuroscience and Regenerative Medicine (CNRM)
Terminated - verified July 23, 2013

Idebenone to Treat Friedreich's Ataxia

Condition:   Friedreich Ataxia
Intervention:   Drug: Idebenone
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 28, 2016

Movement-Related Brain Networks Involved in Hand Dystonia

Conditions:   Movement Disorder;   Focal Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified March 20, 2017

Training for Diagnosing Neurological Disorders

Condition:   Musculoskeletal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 6, 2017

Neuropathology of Spasmodic Dysphonia

Condition:   Voice Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified November 30, 2016

MRI Measurement of Brain Metabolism Across the Sleep-Wake Cycle

Condition:   Sleep
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified February 11, 2014

Pelvic Pain in Women With Endometriosis

Conditions:   Endometriosis;   Pelvic Pain;   Healthy;   Tubal Ligation
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified February 14, 2017

Measuring Levels of SMN in Blood Samples of SMA Patients

Condition:   Spinal Muscular Atrophy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 4, 2017

Evaluation and Treatment of Neurosurgical Disorders

Condition:   Neurologic Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 6, 2016

Evaluation of Primary Chronic Autonomic Failure

Condition:   Autonomic Nervous System Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 10, 2017

Positron Emission Tomography (PET) to Study Brain Signaling

Condition:   Healthy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified June 12, 2015

Brain Anatomy in Dystonia

Conditions:   Dystonia;   Healthy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified March 10, 2015

Magnetic Resonance Spectroscopy to Evaluate Tourette s Syndrome

Condition:   Tourette Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified February 3, 2015

Study of Specimens Obtained During Epilepsy Surgery

Condition:   Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 23, 2017

Phenotype/Genotype Correlations in Movement Disorders

Condition:   Movement Disorder
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 6, 2017

Screening and Natural History: Primary Lateral Sclerosis and Related Disorders

Condition:   Primary Lateral Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified October 5, 2016

Evaluation and Treatment of Patients With Epilepsy

Condition:   Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 23, 2017

Natural History of Stroke: Cause and Development

Conditions:   Nervous System Disease;   Transient Ischemic Attack;   Neurologic Disorders;   Stroke;   Vascular Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 5, 2016

Brain Infusion of Muscimol to Treat Epilepsy

Condition:   Epilepsy
Intervention:   Drug: Muscimol
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified December 24, 2014

Study of Brain and Spinal Cord Tumor Growth and Cyst Development in Patients With Von Hippel Lindau Disease

Conditions:   Hemangioblastoma;   Hippel Lindau Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified October 5, 2016

Genetic Analysis of the Chiari I Malformation

Conditions:   Syringomyelia;   Type I Arnold Chiari Malformation
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 5, 2016

Diagnosis of Pheochromocytoma

Condition:   Pheochromocytoma
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified January 6, 2017

Study of New Magnetic Resonance Imaging Methods of the Brain

Condition:   Healthy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 30, 2017

Study of Inherited Neurological Disorders

Conditions:   Ataxia;   Motor Neuron Disease;   Muscular Disease;   Muscular Dystrophy;   Peripheral Nervous System Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 23, 2017

Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders

Conditions:   Alzheimer's Disease;   Dementia;   Down's Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified December 17, 2012

Evaluation of Patients With HAM/TSP

Conditions:   HTLV-I Infection;   Tropical Spastic Paraparesis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 3, 2017

Diagnosis and History Study of Patients With Different Neurological Conditions

Condition:   Nervous System Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 21, 2016

Botulinum Toxin for the Treatment of Involuntary Movement Disorders

Conditions:   Chorea;   Drug Induced Dyskinesia;   Movement Disorder;   Muscular Disease;   Tic Disorder
Intervention:   Other: Botulinum Toxin
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 25, 2016

Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

Condition:   Multiple Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified November 30, 2016

Human Movement Database

Conditions:   Healthy;   Movement Disorder
Intervention:  
Sponsor:   National Institutes of Health Clinical Center (CC)
Recruiting - verified January 27, 2017