Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Effects of an Educational Intervention on Rehabilitation Clinicians' Practices for Health-related Outcomes After Stroke

Conditions:   Stroke;   Knowledge, Attitudes, Practice;   Physical Disability;   Motor Skills Disorders
Intervention:   Other: Implementation of stroke mobility guidelines
Sponsors:   McGill University;   Heart and Stroke Foundation of Canada - Canadian Partnership for Stroke Recovery;   Réseau Provincial De Recherche En Adaptation-Réadaptation (REPAR)
Not yet recruiting

Carotid Plaque Imaging in Acute Stroke

Conditions:   Stroke;   Ischemic Attack, Transient
Intervention:  
Sponsors:   Ludwig-Maximilians - University of Munich;   Technische Universität München
Active, not recruiting

THALES - Acute STroke or Transient IscHaemic Attack Treated With TicAgreLor and ASA for PrEvention of Stroke and Death

Conditions:   Acute Ischaemic Stroke;   Transient Ischaemic Attack
Interventions:   Drug: Ticagrelor;   Drug: Placebo
Sponsor:   AstraZeneca
Recruiting

The TELSA Trial: Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke

Condition:   Ischemic Stroke
Intervention:   Procedure: Intra-arterial Therapy
Sponsor:   Mercy Health Ohio
Recruiting

Study on the Effectiveness and Safety of Early Rehabilitation After Ischemic Stroke

Conditions:   Brain Ischemia;   Stroke Rehabilitation
Intervention:   Other: rehabilitation
Sponsor:   China Stroke Databank Center
Recruiting

CNS Changes Following Stroke

Condition:   Stroke
Intervention:   Diagnostic Test: MRI
Sponsor:   University of Zurich
Not yet recruiting

Trial of EXenatide in Acute Ischaemic Stroke

Condition:   Acute Ischemic Stroke
Intervention:   Drug: Exenatide Injection
Sponsors:   Neuroscience Trials Australia;   National Health and Medical Research Council, Australia;   Monash University
Recruiting

Obesity Effect on Stroke Recurrence

Condition:   The Effect of Obesity on Recurrent Stroke
Intervention:   Diagnostic Test: Obesity assessment
Sponsor:   Ege University
Completed

Targeted Noninvasive Brain Stimulation to Improve Hand Dexterity in Stroke Patients

Condition:   Stroke
Intervention:   Device: High-definition Transcranial Direct Current Stimulation
Sponsor:   Kessler Foundation
Recruiting

Observational Study on Determinants of Dementia After Stroke

Conditions:   Ischemic Stroke;   Hemorrhagic Stroke
Intervention:  
Sponsor:   Ludwig-Maximilians - University of Munich
Active, not recruiting

Needs Assessment and Quality of Life of Stroke Patients and Their Caregivers

Condition:   Stroke Patients and Their Caregivers
Intervention:  
Sponsor:   Hospices Civils de Lyon
Completed

Stroke complicAtions After TraUmatic expeRieNces and Stress

Condition:   Stroke
Intervention:   Diagnostic Test: Questionnaires
Sponsor:   Johanna Schöner
Completed

Michigan Stroke Transitions Trial

Condition:   Acute Stroke
Interventions:   Other: SCM;   Other: SCM and VSSP
Sponsors:   Michigan State University;   University of Michigan;   Saint Joseph Mercy Health System;   Sparrow Health System;   Massachusetts General Hospital
Completed

An Interactive Distance Solution for Stroke Rehabilitation in the Home Setting

Condition:   Stroke Rehabilitation
Intervention:   Device: DISKO-tool
Sponsors:   Danderyd Hospital;   Karolinska Institutet
Recruiting

Carepartner Collaborative Integrated Therapy in Sub-Acute Stroke

Condition:   Stroke
Interventions:   Behavioral: CARE -CITE;   Behavioral: Standard of care
Sponsor:   Emory University
Recruiting

A Study to Evaluate the DAISe System During Neurointervention for Acute Ischemic Stroke

Condition:   Stroke, Acute
Intervention:   Device: DAISe System
Sponsor:   MIVI Neuroscience, Inc.
Enrolling by invitation

MultiStem® Administration for Stroke Treatment and Enhanced Recovery Study

Condition:   Ischemic Stroke
Interventions:   Biological: MultiStem;   Biological: Placebo
Sponsors:   Athersys, Inc;   Medpace, Inc.
Recruiting

Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke

Conditions:   Cerebrovascular Disorder;   Stroke;   Aging
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Efficacy and Safety Study of GM602 in Patients With Acute Middle Cerebral Artery Ischemic Stroke Within 18 Hours

Condition:   Stroke
Interventions:   Drug: GM602;   Drug: Placebo Comparator
Sponsors:   Genervon Biopharmaceuticals, LLC;   University of California, Los Angeles;   Huntington Hospital;   Hoag Memorial Hospital Presbyterian;   Columbia University;   California Pacific Medical Center Research Institute;   University Hospital Erlangen;   Sarasota Memorial Hospital;   University of Louisville
Completed

Power Training Post-stroke

Condition:   Stroke
Intervention:   Behavioral: POWER training
Sponsor:   VA Office of Research and Development
Completed

Nursing Home Care Intervention Post Stroke

Condition:   Stroke
Intervention:   Other: Nursing educational intervention
Sponsor:   Hospital de Clinicas de Porto Alegre
Active, not recruiting

Transcranial Direct Current Stimulation for Post-stroke Motor Recovery

Conditions:   Stroke, Ischemic;   Motor Activity;   Upper Extremity Paralysis
Interventions:   Device: Sham;   Device: Low dose tDCS;   Device: High dose tDCS;   Behavioral: mCIMT
Sponsors:   Medical University of South Carolina;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Assistive Hip Exoskeleton Study for Stroke

Conditions:   Lower Limb Injury;   Stroke
Intervention:   Device: Powered hip exoskeleton
Sponsor:   Georgia Institute of Technology
Not yet recruiting

The Missing Link- Development and Evaluation of Person-centred Transitions From the Stroke Unit to the Home

Condition:   Stroke
Intervention:  
Sponsor:   Karolinska Institutet
Active, not recruiting

Effect of Remote Ischemic Conditioning on Vascular Health in Stroke Patients

Condition:   Stroke, Lacunar
Intervention:   Procedure: Remote ischemic conditioning
Sponsors:   University of Copenhagen;   Herlev Hospital
Recruiting

Automatic PredICtion of Edema After Stroke

Conditions:   Stroke, Acute;   Brain Edema
Intervention:  
Sponsor:   University Hospital Tuebingen
Recruiting

Effects of Upper Extremity Rehabilitation Robot and Transcranial Direct Current Stimulation Among Patients With Stroke

Condition:   Stroke
Interventions:   Other: Robot and tDCS on-line;   Other: Robot and sham tDCS
Sponsor:   National Rehabilitation Center, Seoul, Korea
Recruiting

Cortical Activity and Gait Function for Robotic Gait Training in Hemiparetic Stroke

Condition:   Stroke
Interventions:   Device: Robot-assisted gait training;   Device: Treadmill gait training
Sponsor:   National Rehabilitation Center, Seoul, Korea
Recruiting

The Effect of Application of Proximal and Distal Upper Rehabilitation Robot With Stroke Patients

Condition:   Stroke
Interventions:   Device: distal upper rehabilitation robot;   Device: proximal upper rehabilitation robot
Sponsor:   National Rehabilitation Center, Seoul, Korea
Not yet recruiting

Combine Transcranial Direct Current Stimulation and Neuromuscular Electrical Stimulation on Stroke Patients

Condition:   Stroke
Interventions:   Device: Combination of tDCS and NMES;   Device: Combination of tDCS and sham NMES;   Device: Combination of sham tDCS and sham NMES
Sponsor:   Kaohsiung Medical University Chung-Ho Memorial Hospital
Completed

Effect of Robot Gait Training With Brain Stimulation on Gait Function in Stroke Patients

Condition:   Stroke
Interventions:   Device: Robot gait training;   Device: Brain stimulation
Sponsor:   Samsung Medical Center
Recruiting

Transcranial Direct Current Stimulation as a Neuroprotection in Acute Stroke Before and After Thrombectomy

Condition:   Acute Ischemic Stroke
Intervention:   Device: Transcranial Direct Current Stimulation (tDCS)
Sponsors:   University of California, Los Angeles;   The City College of New York
Recruiting

Xarelto on Prevention of Stroke and Non-central Nervous System Systemic Embolism in Patients With Non-valvular Atrial Fibrillation in China: A Non-interventional Study

Condition:   Stroke
Intervention:   Drug: Rivaroxaban (Xarelto, BAY 59-7939)
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting

MyndMove Therapy for Severe Hemiparesis of the Upper Limb Following Stroke

Condition:   Hemiparesis of the Upper Limb Following Stroke
Intervention:   Device: MyndMove
Sponsors:   MyndTec Inc.;   University Health Network, Toronto
Active, not recruiting

Repetitive Transcranial Magnetic Stimulation in Post Stroke Upper Limb Spasticity

Condition:   Spasticity as Sequela of Stroke
Intervention:   Device: Repetitive transcranial magnetic stimulation
Sponsor:   Izmir Katip Celebi University
Recruiting

MyHand: An Active Hand Orthosis for Stroke Patients

Condition:   Stroke
Interventions:   Device: EMG Band;   Device: Shoulder harness
Sponsors:   Columbia University;   Wallace H. Coulter Foundation;   U.S. National Science Foundation
Completed

Sleep for Stroke Management and Recovery Trial

Conditions:   Ischemic Stroke;   Sleep Apnea;   Sleep Apnea, Obstructive;   TIA;   Stroke;   CPAP;   Telemedicine;   Home Sleep Apnea Test;   Randomized Clinical Trial;   Multicenter Trial
Intervention:   Device: CPAP
Sponsors:   University of Michigan;   National Institute of Neurological Disorders and Stroke (NINDS);   FusionHealth LLC;   Medical University of South Carolina;   University of Cincinnati
Recruiting

GORE® Septal Occluder Device for Patent Foramen Ovale (PFO) Closure in Stroke Patients

Conditions:   Stroke;   Transient Ischemic Attack
Interventions:   Device: Septal Occluder Device;   Drug: Antiplatelet Medical Therapy
Sponsor:   W.L.Gore & Associates
Active, not recruiting

On-Track Feasibility Study of a Rehabilitation System for Stroke Patients

Condition:   Cerebrovascular Accident
Intervention:   Other: Feasibility of On-Track
Sponsors:   Imperial College London;   Imperial College Healthcare NHS Trust
Recruiting

Penumbral Rescue by Normobaric O2 Administration in Patients With Ischemic Stroke and Target Mismatch ProFile

Condition:   Acute Ischemic Stroke
Interventions:   Drug: Medical oxygen;   Other: Standard of care
Sponsor:   University Hospital Tuebingen
Recruiting

Fluoxetine for Visual Recovery After Ischemic Stroke

Conditions:   Acute Stroke;   Visual Field Loss
Interventions:   Drug: Fluoxetine;   Drug: Placebo
Sponsor:   Bogachan Sahin
Recruiting

Apixaban for Early Prevention of Recurrent Embolic Stroke and Hemorrhagic Transformation

Conditions:   Transient Ischemic Attack;   Stroke;   Atrial Fibrillation
Interventions:   Drug: Apixaban;   Drug: Warfarin
Sponsors:   University of South Florida;   Bristol-Myers Squibb
Completed

Using SystemCHANGE™ to Enhance Medication Adherence in Older Adult Stroke Survivors

Condition:   Stroke, Ischemic
Interventions:   Behavioral: SystemCHANGE™;   Behavioral: Attention-Control
Sponsors:   University of Missouri, Kansas City;   Saint Luke's Health System
Completed

Upper Limb Mirror Therapy With TENS to Improve Upper Limb Functions in Patients With Sub-acute Stroke

Condition:   Stroke
Interventions:   Device: Transcutaneous electrical nerve stimulation (TENS);   Behavioral: Mirror Therapy (MT);   Behavioral: sham-Mirror Therapy (sham-MT);   Behavioral: Conventional Rehabilitation Program
Sponsor:   The Hong Kong Polytechnic University
Not yet recruiting

Efficacy and Safety of Jiedu Tongluo Granules for Post-stroke Depression

Condition:   Post-stroke Depression
Interventions:   Drug: Jiedu Tongluo granules;   Drug: Placebo
Sponsor:   Xiyuan Hospital of China Academy of Chinese Medical Sciences
Completed

Resistive Training Combined With Nutritional Therapy After Stroke

Condition:   Stroke
Interventions:   Other: Protein;   Other: Placebo
Sponsors:   VA Office of Research and Development;   Baltimore VA Medical Center
Recruiting

Oral Factor XIa Inhibitor for the Prevention of New Ischemic Stroke in Patients Receiving Aspirin and Clopidogrel Following Acute Ischemic Stroke or Transient Ischemic Attack (TIA)

Conditions:   Acute Ischemic Stroke;   Transient Ischemic Attack (TIA)
Interventions:   Drug: BMS-986177;   Other: BMS-986177 Placebo;   Drug: Clopidogrel;   Drug: Aspirin
Sponsors:   Bristol-Myers Squibb;   Janssen, LP
Recruiting

Therapies for Recovery of Hand Function After Stroke

Conditions:   Stroke;   Upper Extremity Paresis;   Hemiplegia
Interventions:   Device: Electrical Stimulator;   Behavioral: Occupational Therapy
Sponsors:   MetroHealth Medical Center;   Kessler Foundation;   National Institutes of Health (NIH);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   The Cleveland Clinic
Recruiting

Efficacy of Sovateltide (PMZ-1620) in Patients of Acute Ischemic Stroke

Conditions:   Cerebral Ischemia;   Cerebral Infarction;   Stroke, Acute
Interventions:   Drug: Normal Saline along with standard treatment;   Drug: PMZ-1620 (sovateltide) along with standard treatment
Sponsor:   Pharmazz, Inc.
Not yet recruiting

PMZ-1620 (Sovateltide) in Acute Ischemic Stroke Patients

Conditions:   Acute Stroke;   Cerebral Ischemia
Interventions:   Drug: Normal Saline along with standard treatment;   Drug: PMZ-1620 along with standard treatment
Sponsor:   Pharmazz, Inc.
Completed

SaeboGlove Therapy for Severe Upper Limb Disability and Severe Hand Impairment After Stroke

Condition:   Stroke
Interventions:   Device: SaeboGlove therapy;   Behavioral: Usual care
Sponsors:   NHS Greater Glasgow and Clyde;   University of Glasgow
Not yet recruiting

Effects of Upper Extremity Rehabilitation Robot and Transcranial Direct Current Stimulation in Subacute Stroke

Condition:   Stroke
Interventions:   Other: Robot and tDCS on-line;   Other: Robot and sham tDCS
Sponsor:   National Rehabilitation Center, Seoul, Korea
Recruiting

NOACs for Stroke Prevention in Patients With Atrial Fibrillation and Previous ICH

Conditions:   Atrial Fibrillation;   Intracerebral Hemorrhage
Interventions:   Drug: NOAC;   Drug: Acetylsalicylic Acid
Sponsor:   Population Health Research Institute
Active, not recruiting

Sensorimotor Integration Exercises on Post-stroke Balance and Fall Efficacy

Condition:   Stroke
Interventions:   Behavioral: sensory motor integration exercises;   Behavioral: conventional physiotherapy
Sponsors:   Mahidol University;   University of Medical Technology, Yangon
Completed

VAlidity and Reliability of the Telephone Interview Form for Stroke Outcome Evaluation

Condition:   Stroke
Intervention:   Diagnostic Test: Telephone Interview Form
Sponsor:   Dongzhimen Hospital, Beijing
Not yet recruiting

Imatinib in Acute Ischaemic Stroke

Condition:   Acute Ischaemic Stroke
Interventions:   Drug: Imatinib 400mg;   Drug: Placebo Oral Tablet
Sponsor:   Niaz Ahmed
Recruiting

Verapamil for Neuroprotection in Stroke

Condition:   Ischemic Stroke
Intervention:   Drug: Verapamil
Sponsor:   Global Neurosciences Institute
Recruiting

FRench Acute Cerebral Multimodal Imaging to Select Patient for MEchanical Thrombectomy

Condition:   Acute Ischemic Stroke
Intervention:   Other: Multimodal brain imaging
Sponsor:   University Hospital, Toulouse
Active, not recruiting

The Effect of a Ankle Assist Robot on Gait Function and Cardiopulmonary Metabolic Efficiency in Stroke Patients

Conditions:   Stroke;   Gait, Hemiplegic
Intervention:   Device: Ankle Assist Robot
Sponsor:   Samsung Medical Center
Completed

Transcranial Alternating Current Stimulation Treating Post-stroke Depression

Condition:   Post-stroke Depression
Interventions:   Device: NEXALIN ADI AC stimulator;   Device: Pseudo-stimulator
Sponsor:   Xuanwu Hospital, Beijing
Recruiting

Post-Stroke Aphasia and Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment Study

Conditions:   Aphasia;   Stroke
Intervention:   Device: Magstim SuperRapid
Sponsors:   University of Alabama at Birmingham;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute on Deafness and Other Communication Disorders (NIDCD)
Completed

Moving a Paralyzed Hand Through Use of a Brain-Computer Interface

Condition:   Stroke
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Center for Neuroscience and Regenerative Medicine (CNRM)
Terminated

Atrial Fibrillation Detected by Continuous ECG Monitoring

Conditions:   Atrial Fibrillation;   Stroke;   Hypertension;   Diabetes
Intervention:   Device: Implantable loop recorder (Medtronic Reveal LINQ(TM))
Sponsors:   Rigshospitalet, Denmark;   Bispebjerg Hospital;   Zealand University Hospital;   Odense University Hospital;   University of Southern Denmark;   Aalborg University
Active, not recruiting

Efficacy and Safety Study of rTMS for Upper Extremity Motor Function Recovery in Ischemic Stroke Patients

Conditions:   Stroke;   Hemiplegia
Intervention:   Device: Low frequency rTMS
Sponsors:   Seoul National University Bundang Hospital;   DongGuk University;   Seoul National University Hospital;   REMED
Completed

Psychoeducation for Transient Ischaemic Attack and Minor Stroke

Conditions:   Transient Ischaemic Attack;   Stroke
Intervention:   Behavioral: Psychoeducation
Sponsors:   University of Nottingham;   The Stroke Association, United Kingdom;   Nottingham University Hospitals NHS Trust
Active, not recruiting

Stroke Patients' Outpatient Rehabilitation Therapy (SPORT)

Conditions:   Stroke;   Incentives;   Stroke Rehabilitation
Interventions:   Behavioral: Transportation incentives;   Behavioral: Transportation and rehabilitation services incentives
Sponsors:   National University, Singapore;   Ministry of Health, Singapore;   Duke-NUS Graduate Medical School;   Changi General Hospital;   Singapore General Hospital
Active, not recruiting

Sensory Neuromodulation Protocol for the Treatment of Post-stroke Oropharyngeal Dysphagia.

Conditions:   Swallowing Disorder;   Dysphagia;   Stroke;   Neurophysiologic Abnormality
Interventions:   Device: rTMS active and sham;   Device: PES active and sham;   Dietary Supplement: Capsaicin active and placebo
Sponsor:   Hospital de Mataró
Completed

The Norwegian Tenecteplase Stroke Trial 2

Conditions:   Stroke, Acute;   Cerebrovascular Disorders;   Ischemic Stroke
Interventions:   Drug: Tenecteplase;   Drug: Alteplase
Sponsor:   Haukeland University Hospital
Not yet recruiting

Transcutaneous Vagus Nerve Stimulation (tVNS) and Robotic Training to Improve Arm Function After Stroke

Conditions:   Stroke;   Cerebrovascular Accident (CVA);   Hemiparesis
Interventions:   Device: Transcutaneous Vagus Nerve Stimulation (tVNS);   Device: Sham Transcutaneous Vagus Nerve Stimulation (tVNS)
Sponsor:   Northwell Health
Recruiting

Natural History of Stroke: Cause and Development

Conditions:   Brain Disease;   Ischemic Attack, Transient;   Cerebrovascular Accident;   Cerebrovascular Disorder;   Vascular Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Transcranial Direct Current Stimulation Combined Neuromuscular Electrical Stimulation on Motor Recovery in Stroke

Condition:   Chronic Stroke
Interventions:   Combination Product: tDCS(Intelect Mobile Stimulation and Combination, DJO, France);   Combination Product: NMES(Enraf Nonius, Endomed-182, Netherlands)
Sponsor:   Kaohsiung Medical University Chung-Ho Memorial Hospital
Completed

Assessment of the WATCHMAN™ Device in Patients Unsuitable for Oral Anticoagulation

Condition:   Stroke
Interventions:   Device: WATCHMAN LAAC Device Implant;   Drug: Single Antiplatelet Therapy or No Therapy (Control)
Sponsor:   Boston Scientific Corporation
Recruiting

Mobile Phones in Cryptogenic Stroke Patients Bringing Single Lead ECGs to Detect Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Ischemic Stroke;   Transient Ischemic Attack
Interventions:   Device: Single lead ECG device;   Device: 7-Day Holter monitor.
Sponsors:   Leiden University Medical Center;   Medical Center Haaglanden;   Groene Hart Ziekenhuis;   Herning Hospital;   Alrijne Hospital;   Reinier de Graaf Groep
Recruiting

Fluoxetine Opens Window to Improve Motor Recovery After Stroke

Conditions:   Stroke;   Cerebrovascular Accident;   Cerebral Infarction;   Brain Infarction;   Brain Ischemia;   Cerebrovascular Disorders;   Brain Diseases;   Central Nervous System Diseases;   Nervous System Diseases;   Vascular Diseases
Interventions:   Drug: Fluoxetine Hydrochloride;   Other: Placebo;   Behavioral: Exercise Program
Sponsors:   University Health Network, Toronto;   University of British Columbia;   Sunnybrook Health Sciences Centre;   University of Calgary;   Dalhousie University;   Parkwood Hospital, London, Ontario;   Riverview Health Centre Foundation;   Memorial University of Newfoundland;   Applied Health Research Centre;   Brain Canada;   Heart and Stroke Foundation Canadian Partnership for Stroke Recovery
Recruiting

Determining the Optimal Dose of Tenecteplase Before Endovascular Therapy for Ischaemic Stroke (EXTEND-IA TNK Part 2)

Condition:   Ischemic Stroke
Intervention:   Drug: Tenecteplase
Sponsors:   Neuroscience Trials Australia;   The Florey Institute of Neuroscience and Mental Health
Active, not recruiting

Blood Pressure Measurement Methods and Prediction of Intracranial Hemorrhage After Thrombectomy in Stroke

Conditions:   Acute Stroke;   Blood Pressure;   Cerebral Hemorrhage
Interventions:   Device: Clearsight device (Edwards) around the finger;   Device: Intermittent blood pressure measurements with cuff.
Sponsor:   Fondation Ophtalmologique Adolphe de Rothschild
Recruiting

Endovascular Treatment Key Technique and Emergency Work Flow Improvement of Acute Ischemic Stroke

Condition:   Intracranial Artery Occlusion With Infarction (Disorder)
Intervention:  
Sponsor:   Beijing Tiantan Hospital
Completed

Impact of Left Atrial Appendage Exclusion on Short-Term Clinical Outcomes and Long-Term Stroke Incidence

Conditions:   Atrial Fibrillation;   Thromboembolism;   Cerebrovascular Accident
Intervention:   Procedure: Left Atrial Appendage Ligation
Sponsors:   London Health Sciences Centre;   Ospedale San Raffaele
Completed

Dabigatran for Mitral Stenosis Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Mitral Stenosis
Interventions:   Drug: Dabigatran etexilate;   Drug: Warfarin
Sponsor:   The University of Hong Kong
Not yet recruiting

fMRI Neurofeedback for Motor Rehabilitation

Conditions:   Stroke;   fMRI
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Guanfacine for the Treatment of Spatial Neglect and Impaired Vigilance

Conditions:   Stroke;   Hemispatial Neglect
Interventions:   Drug: Guanfacine;   Drug: Placebo
Sponsors:   Imperial College London;   Wellcome Trust
Completed

Xarelto on Prevention of Stroke and Non-Central Nervous Systemic Embolism in Renally Impaired Korean Patients With Non-valvular Atrial Fibrillation

Condition:   Non-valvular Atrial Fibrillation (NVAF)
Intervention:   Drug: Rivaroxaban(Xarelto,BAY 59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting

Transcutaneous ARFI Ultrasound for Differentiating Carotid Plaque With High Stroke Risk

Conditions:   Plaque, Atherosclerotic;   Carotid Artery Plaque;   Carotid Stenosis
Intervention:   Diagnostic Test: Acoustic Radiation Force Impulse (ARFI) ultrasound
Sponsors:   University of North Carolina, Chapel Hill;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Peripheral Nerve Stimulation for Shoulder Pain: Dose Response

Conditions:   Stroke;   Shoulder Pain
Intervention:   Device: Peripheral Nerve Stimulation
Sponsors:   MetroHealth Medical Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   Case Western Reserve University
Active, not recruiting

Gait Mate: Examining Neural Networks Engaged During Lower Extremity Movement in the MRI

Conditions:   Stroke;   Motor Activity
Intervention:   Device: GAITRite assessment
Sponsors:   Medical University of South Carolina;   MUSC Center for Biomedical Research Excellence (COBRE) in Stroke Recovery
Completed

Cerebellar Transcranial Direct Current Stimulation and Aphasia Treatment

Condition:   Stroke
Interventions:   Device: Anodal or Cathodal tDCS;   Device: Sham;   Behavioral: Computerized naming therapy
Sponsors:   Johns Hopkins University;   National Institute on Deafness and Other Communication Disorders (NIDCD)
Recruiting

Rivaroxaban vs Warfarin for SPAF in Multi-morbid Patients

Condition:   Nonvalvular Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Vitamin K antagonist(VKA)
Sponsor:   Bayer
Active, not recruiting

Total Cerebral Protection With Embolic Protection Devices Thoracic Aortic Stenting

Conditions:   Stroke;   Silent Cerebral Infarct
Intervention:   Device: Sentinel and Spider
Sponsors:   Imperial College London;   St Mary's Hospital, London
Suspended

Evaluation of New Diagnostic Methods of Cardio-embolic Related (Atrial Fibrillation) Cerebral Infarction

Condition:   Stroke
Interventions:   Procedure: MRI;   Procedure: Abdominal scanner
Sponsor:   Hopital Foch
Recruiting

STOP-MSU: Stopping Haemorrhage With Tranexamic Acid for Hyperacute Onset Presentation Including Mobile Stroke Units

Condition:   Intracerebral Haemorrhage
Interventions:   Drug: Tranexamic Acid;   Drug: Normal saline
Sponsors:   Neuroscience Trials Australia;   The Florey Institute of Neuroscience and Mental Health
Recruiting

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk

Condition:   Dyslipidemia
Interventions:   Biological: Evolocumab;   Drug: Placebo
Sponsor:   Amgen
Completed

Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity

Conditions:   Overweight;   Obesity
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

Pneumoperitoneum and Trendelenburg Position on Fluid Responsiveness

Condition:   Fluid Responsiveness
Intervention:   Other: Ringer Lactate
Sponsor:   Kocaeli University
Completed

Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Biological: Apolipoprotein A-I [human] (apoA-I);   Other: Placebo
Sponsor:   CSL Behring
Recruiting

Looking Glass: Bimanual Balanced Reaching With Visual Biofeedback

Conditions:   Stroke;   Stroke, Acute;   Healthy
Interventions:   Other: Veridical Visual Feedback;   Other: Augmented Visual Feedback;   Other: Healthy Comparative Reaching Task
Sponsor:   Shirley Ryan AbilityLab
Recruiting

ReachPR Trial Resynchronization Therapy in Heart Failure Patients With Prolonged PR Interval

Conditions:   Atrioventricular Dyssynchrony;   Heart Failure
Intervention:   Device: Cardiac resynchronization therapy
Sponsor:   Maastricht University Medical Center
Recruiting

A Nationwide Observational Study Looking at Effectiveness and Bleeding Complications of NOACs vs. VKA in Non-valvular Atrial Fibrillation Patients.

Condition:   Non-valvular Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Apixaban (Eliquis);   Drug: Dabigatran etexilate (Pradaxa);   Drug: Warfarin (Marevan)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

Safety of Terminating the Use of Aspirin After Left Atrial Appendage Closure

Conditions:   Atrial Fibrillation;   Stroke;   Left Atrial Appendage Thrombosis
Intervention:   Drug: Termination of aspirin
Sponsor:   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Recruiting

STOP-AUST: The Spot Sign and Tranexamic Acid On Preventing ICH Growth - AUStralasia Trial

Conditions:   Intracerebral Haemorrhage;   Stroke
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsor:   Neuroscience Trials Australia
Active, not recruiting

Multimodal Treatment for Hemiplegic Shoulder Pain

Conditions:   Stroke;   Shoulder Pain
Interventions:   Device: Peripheral Nerve Stimulation;   Other: Physical Therapy;   Other: Sham-PT;   Device: Sham-PNS
Sponsors:   MetroHealth Medical Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   Case Western Reserve University;   Shirley Ryan AbilityLab
Recruiting

Spaced Versus Massed Skill Learning

Condition:   Healthy Volunteer
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

ACS Registry - A Non-interventional Study to Estimate the Rates of Outcomes in ACS Patients in Moscow

Conditions:   Heart Attack;   Stroke;   Cardiovascular Death
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Prospective Study on Embolization of Intracranial Aneurysms With Pipeline™ Embolization Device

Condition:   Intracranial Aneurysm
Intervention:   Device: Pipeline™ Embolization Device/ Pipeline™Flex Embolization Device
Sponsor:   Medtronic Neurovascular Clinical Affairs
Completed

Investigating Usability of c-SIGHT in the Homes of Brain Injury Survivors

Conditions:   Stroke;   Brain Injuries;   Spatial Neglect;   Attention Deficit
Intervention:   Behavioral: c-SIGHT (computorized spatial innatention grasping home-based therapy)
Sponsors:   University of East Anglia;   National Institute for Health Research, United Kingdom
Recruiting

EXCEL Clinical Trial

Conditions:   Chronic Coronary Occlusion;   Unprotected Left Main Coronary Artery Disease;   Stent Thrombosis;   Vascular Disease;   Myocardial Ischemia;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Artery Disease;   Coronary Restenosis
Interventions:   Device: Percutaneous Coronary Intervention;   Procedure: CABG
Sponsor:   Abbott Medical Devices
Completed

Enhancing Written Communication in Persons With Aphasia

Conditions:   Aphasia;   Stroke
Interventions:   Behavioral: ORLA;   Behavioral: ORLA + Writing
Sponsor:   Shirley Ryan AbilityLab
Active, not recruiting

Large-Scale Online Studies of Motor Responses and Cognition

Condition:   Healthy Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting

Assessing Clinical Endpoints and Biomarkers in Myotonic Dystrophy Type-1 and Type 2 (ASCEND-DM)

Conditions:   Myotonic Dystrophy Type-1;   Myotonic Dystrophy Type-2
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders

Conditions:   Alzheimer's Disease;   Dementia;   Down's Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Infants With Spinal Muscular Atrophy Type I

Condition:   Spinal Muscular Atrophy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

A Study to Assess All-Cause Mortality and Cardiovascular Morbidity in Participants With Chronic Kidney Disease (CKD) on Dialysis and Those Not on Renal Replacement Therapy Receiving Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) or Reference Erythropoietin Stimulating Agents (ESAs)

Condition:   Chronic Renal Anemia
Interventions:   Drug: Darbepoetin Alfa;   Drug: Epoetin Alfa;   Drug: Epoetin Beta;   Drug: methoxy polyethylene glycol-epoetin beta
Sponsor:   Hoffmann-La Roche
Completed

BedMed-Frail: Does the Potential Benefit of Bedtime Antihypertensive Prescribing Extend to Frail Populations?

Conditions:   Hypertension;   Dementia
Intervention:   Other: Bedtime administration of the participant's pre-existing antihypertensive medications
Sponsors:   University of Alberta;   Alberta Innovates Health Solutions;   Canadian Institutes of Health Research (CIHR);   EnACt
Not yet recruiting

Destination Therapy Post Approval Study

Condition:   Chronic Heart Failure
Intervention:   Device: HeartWare Ventricular Assist Device
Sponsor:   Medtronic Cardiac Rhythm and Heart Failure
Recruiting

Thumb-ECG Ambulant Screening for Atrial Fibrillation in Patients Treated for Hyperthyroidism (TAMBOURINE)

Conditions:   Hyperthyroidism;   Atrial Fibrillation
Intervention:  
Sponsor:   Karolinska Institutet
Recruiting

Functional Assessment in Elderly MI Patients With Multivessel Disease

Condition:   Myocardial Infarction
Interventions:   Other: Culprit-only revascularization;   Other: Complete functionally-guided revascularization
Sponsor:   Consorzio Futuro in Ricerca
Recruiting

Transfusion Trigger After Operations in High Cardiac Risk Patients

Conditions:   Myocardial Infarction;   Coronary Revascularization;   Acute Renal Failure
Intervention:   Procedure: Blood Transfusion
Sponsor:   VA Office of Research and Development
Recruiting

Major Outcomes With Personalized Dialysate TEMPerature

Conditions:   Kidney Diseases;   End-Stage Kidney Disease;   Hemodialysis
Intervention:   Other: Personalized Dialysate Temperature
Sponsors:   Lawson Health Research Institute;   Population Health Research Institute;   Ottawa Hospital Research Institute;   Dialysis Clinic, Inc.;   Cancer Care Ontario;   Institute for Clinical Evaluative Sciences;   The Kidney Foundation of Canada;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Active, not recruiting

Trial to Evaluate Parenteral Treprostinil and Riociguat on Right Ventriculo-vascular Coupling and Morphology in Those With Advanced PAH

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Treprostinil Injectable Product;   Drug: Riociguat Pill
Sponsor:   University of Arizona
Recruiting

Thoraflex™ Hybrid IDE Study

Conditions:   Aortic Aneurysm;   Aortic Dissection;   Aortic Rupture
Intervention:   Device: Thoraflex™ Hybrid Device
Sponsors:   Bolton Medical;   Vascutek Ltd.
Active, not recruiting

Prospective Outpatient Registry of Myocardial Infarction Patients

Condition:   Myocardial Infarction
Intervention:  
Sponsor:   National Research Center for Preventive Medicine
Active, not recruiting

PHIL in the Treatment of Intracranial dAVF.

Condition:   Arteriovenous Dural Fistula
Intervention:   Device: PHIL® Liquid Embolic System
Sponsor:   Microvention-Terumo, Inc.
Recruiting

Metformin And Cardiovascular Effectiveness vs SGLT2 (MACES)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: SGLT2;   Drug: Metformin
Sponsor:   Brigham and Women's Hospital
Active, not recruiting

AntiCoagulation Tracking InterVention and Evaluation

Conditions:   Anticoagulation;   Atrial Fibrillation;   Atrial Flutter;   Pulmonary Embolus/Emboli;   Deep Vein Thrombosis;   Stroke;   Hypercoagulability
Interventions:   Other: Panel Management for Anticoagulation Therapy;   Other: Usual Care
Sponsor:   University of California, San Francisco
Not yet recruiting

Pharmacogenomics of Anti-platelet Intervention-2 (PAPI-2) Study

Conditions:   Cardiovascular Diseases;   Acute Coronary Syndrome
Interventions:   Drug: clopidogrel;   Drug: prasugrel
Sponsors:   University of Maryland, Baltimore;   National Heart, Lung, and Blood Institute (NHLBI)
Terminated

Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study

Condition:   Bicuspid Aortic Valve
Intervention:   Device: Medtronic TAVR Systems
Sponsor:   Medtronic Cardiovascular
Recruiting

Intracranial Arterial Stenosis and Resin of Cannabis Use

Condition:   Cannabis Users
Intervention:   Other: Cerebral MRI and MRA
Sponsor:   University Hospital, Strasbourg, France
Recruiting

Direct Intra-arterial Thrombectomy in Order to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals

Conditions:   Ischemic Stroke;   Large Vessel Occlusion;   Thrombectomy;   Thrombosis;   Alteplase
Interventions:   Procedure: intra-arterial thrombectomy;   Drug: Intravenous thrombolysis
Sponsors:   Changhai Hospital;   National Health and Family Planning Commission, P.R.China;   Wu Jieping Medical Foundation;   Cardiovascular Chinese Research Center;   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Recruiting

Ticagrelor Compared to Clopidogrel in Acute Coronary Syndromes

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Ticagrelor 90mg;   Drug: Clopidogrel 75mg;   Drug: acetylsalicylic acid (ASA) 81mg
Sponsors:   McGill University Health Center;   Canadian Institutes of Health Research (CIHR)
Recruiting

A Diagnostic Test on DeepDoc-an AI-based Decision Support System

Conditions:   Stroke;   Headache;   Vertigo;   Meningitis/Encephalitis
Intervention:   Device: DeepDoc AI-based Decision Support System
Sponsor:   Xijing Hospital
Not yet recruiting

Evaluation of Ambulatory ECG Telemetry for the Early Detection of Atrial Fibrillation During Hospital Assessment of Cerebral Infarction

Condition:   Cerebral Infarction
Intervention:   Device: ECG telemetry
Sponsor:   Hopital Foch
Recruiting

A Trial Evaluating Vitamin D Normalization on Major Adverse Cardiovascular-Related Events Among Myocardial Infarction Patients

Conditions:   Death;   Myocardial Infarction;   Cerebral Vascular Accident;   Heart Failure Hospitalization
Intervention:   Biological: Vitamin D3
Sponsor:   Intermountain Health Care, Inc.
Recruiting

Effectiveness of a Proactive Cardiovascular Primary Prevention Strategy, With or Without the Use of Coronary Calcium Screening, in Preventing Future Major Adverse Cardiac Events

Condition:   Cardiovascular Primary Prevention Strategy
Interventions:   Combination Product: Coronary Artery Calcium Screening and Statin Treatment;   Other: Standard Treatment
Sponsor:   Intermountain Health Care, Inc.
Recruiting

Sleep Disordered Breathing (SDB) Prevalence and Cardiovascular Outcomes of Myocardial Infarction (MI) Survivors

Conditions:   Acute Myocardial Infarction;   Sleep Apnea
Intervention:   Diagnostic Test: Polygraphy
Sponsors:   Assistance Publique - Hôpitaux de Paris;   National Research Agency, France
Recruiting

Severe Sepsis/Septic Shock on Admission to the General Surgical ICU

Conditions:   Septic Shock;   Multiple Organ Failure;   Fatal Outcome
Intervention:  
Sponsor:   Mahidol University
Completed

Diuretic Comparison Project

Condition:   Hypertension
Interventions:   Drug: Hydrochlorothiazide (HCTZ);   Drug: Chlorthalidone
Sponsor:   VA Office of Research and Development
Recruiting

Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia

Condition:   Eligible Men or Women Considered High Risk for Atherosclerotic Cardiovascular Disease (CVD)
Interventions:   Drug: Epanova® (omega-3 carboxylic acids);   Drug: corn oil control
Sponsors:   AstraZeneca;   The Cleveland Clinic;   Quintiles, Inc.
Active, not recruiting

Cardiac Rehabilitation for TIA Patients

Condition:   TIA (Transient Ischemic Attack)
Intervention:   Behavioral: Comprehensive Cardiac Rehabilitation (CR)
Sponsors:   Lawson Health Research Institute;   Heart and Stroke Foundation of Ontario
Completed

The Intensive Comprehensive Aphasia Program (ICAP)

Conditions:   Aphasia;   Stroke
Intervention:   Behavioral: Speech and Language Therapy
Sponsors:   Shirley Ryan AbilityLab;   Northwestern University
Active, not recruiting

Anakinra for the Treatment of Chronically Inflamed White Matter Lesions in Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:   Drug: Anakinra
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Modulating the Hippocampal and Striatal Memory Networks With rTMS

Condition:   Normal Behavioral Patterns
Intervention:   Other: RTMS
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Prognosis of Patients With Acute Coronary Syndrome Complicated With Renal Insufficiency(PACS-RI)

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   Henan Institute of Cardiovascular Epidemiology
Recruiting

Feasibility of Endosphenoidal Coil Placement for Imaging of the Sella During Transsphenoidal Surgery

Condition:   Pituitary Neoplasm
Intervention:   Other: ESC
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Cytokine Microdialysis for Real-Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade

Condition:   Glioblastoma
Interventions:   Drug: Nivolumab;   Drug: BMS-986016
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Myalgic Encephalomyelitis Chronic Fatigue at the National Institutes of Health

Condition:   Chronic Fatigue Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Tumor Related Epilepsy

Conditions:   Epilepsy;   Cancer;   Brain Neoplasm
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection

Conditions:   HIV Infections;   Neurologic Disorders
Intervention:   Drug: Anakinra
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Johns Hopkins University
Terminated

Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD

Condition:   Coronary Artery Disease
Interventions:   Drug: High dose potent statin;   Drug: ACE-I (lisinopril) or ARB (losartan);   Drug: Aspirin;   Behavioral: Lifestyle Counseling;   Behavioral: Quality of Life Questionnaires
Sponsors:   University of Florida;   United States Department of Defense
Recruiting

HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)

Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Drug: Darunavir;   Drug: Ritonavir;   Drug: dolutegravir;   Drug: Tenofovir alafenamide (TAF)
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk

Conditions:   Type 2 Diabetes Mellitus;   Chronic Kidney Diseases
Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: Placebo
Sponsor:   Sanofi
Recruiting

Oral Guanabenz for Multiple Sclerosis

Conditions:   Multiple Sclerosis, Relapsing-Remitting;   Multiple Sclerosis
Intervention:   Drug: Guanabenz
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy

Conditions:   Giant Axonal Neuropathy;   Gene Transfer
Intervention:   Drug: Intrathecal Delivery of scAAV9/JeT-GAN
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Comparison of Electrophysiologic and Ultrasound Guidance for Onabotulinum Toxin A Injections in Focal Upper Extremity Dystonia and Spasticity

Conditions:   Dystonia;   Focal Dystonia;   Musician's Dystonia;   Muscle Spasticity
Interventions:   Procedure: BoNT injection;   Procedure: US guidance;   Procedure: E-stim Guidance
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Neural Basis of Decision-Making Deficits in Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Uniformed Services University of the Health Sciences
Recruiting

Deep Brain Stimulation for Refractory Alcoholism

Condition:   Alcoholism
Intervention:   Procedure: Implantation of Deep Brain Stimulation
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Withdrawn

Transcranial Magnetic Stimulation for Focal Hand Dystonia

Condition:   Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Taurine Therapy for SSADH Deficiency

Condition:   Succinic Semialdehyde Dehydrogenase
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Buspirone Therapy for Localized Epilepsy

Conditions:   Anxiety Disorder;   Seizures;   Epilepsy;   Partial Epilepsy;   Depression
Intervention:   Drug: Buspirone
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Combined Deep Brain Stimulation for Parkinson's Disease

Condition:   Parkinson Disease
Intervention:   Procedure: DBS Surgery
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Withdrawn

Octanoic Acid for Essential Tremor

Condition:   Essential Tremor
Intervention:   Drug: Octanoic Acid
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Effect of Functional Exercise in Patients With Spinal Bulbar Muscular Atrophy

Condition:   Motor Neuron Disease
Interventions:   Behavioral: A functional exercise program;   Behavioral: A stretching exercise program
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Structural and Functional Neuroimaging Studies of Combat Veterans

Conditions:   Traumatic Brain Injury;   PTSD
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Center for Neuroscience and Regenerative Medicine (CNRM)
Completed

Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients

Conditions:   Neoplasms;   Nervous System Disease;   Vestibular Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Ethanol Response in Essential Tremor: Clinical and Neurophysiological Correlates

Condition:   Essential Tremor
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Oxidative Stress in Motor Neuron Disease: COSMOS Add-On Study

Conditions:   Motor Neuron Disease;   Primary Lateral Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Cerebral Activity Related to Primary Motor Stereotypies in Children: An EEG Study.

Condition:   Movement Disorder
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Recording and Modulation of Neuronal Mechanisms During Operant Conditioning: a MEG Study

Condition:   Central Nervous System
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Depression;   Depressive Disorder, Major
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Language Mapping in Patients With Epilepsy

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Partial Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Relationship of HHV-6B Virus to Seizures and Brain Injury

Conditions:   Epilepsy;   HHV6B Infection
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Brain Changes in Blepharospasm

Conditions:   Dystonia;   Focal Dystonia;   Cerebellar Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Biomarkers in Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Long-Term Motor Learning in Focal Hand Dystonia

Condition:   Focal Hand Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Reference Values for Plasma Catechols

Conditions:   Healthy Volunteers;   Normal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

MULTivessel Immediate Versus STAged RevaScularization in Acute Myocardial Infarction -The MULTISTARS AMI Trial

Conditions:   ST-elevation Myocardial Infarction;   Multivessel Coronary Disease
Interventions:   Procedure: Staged complete PCI;   Procedure: Immediate complete PCI;   Device: Synergy™ stent
Sponsor:   University of Zurich
Recruiting

A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo
Sponsor:   Novo Nordisk A/S
Recruiting

Evaluation of Primary Chronic Autonomic Failure

Condition:   Autonomic Nervous System Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Registration of Idarucizumab for Patients With IntraCranial Hemorrhage

Condition:   Intracranial Hemorrhage
Interventions:   Drug: Dabigatran Etexilate Oral Capsule [Pradaxa];   Drug: Idarucizumab 2.5 GM/50 ML Intravenous Solution [PRAXBIND];   Drug: Vitamin K antagonist
Sponsor:   University Hospital, Essen
Not yet recruiting

Magnetic Resonance Spectroscopy to Evaluate Tourette s Syndrome

Condition:   Tourette Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Screening and Natural History: Primary Lateral Sclerosis and Related Disorders

Condition:   Primary Lateral Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Evaluation and Treatment of Patients With Epilepsy

Condition:   Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Study of Inherited Neurological Disorders

Conditions:   Motor Neuron Disease;   Muscular Disease;   Muscular Dystrophy;   Peripheral Nervous System Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Diagnosis and History Study of Patients With Different Neurological Conditions

Condition:   Nervous System Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation

Condition:   Mitral Valve Regurgitation
Interventions:   Device: Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR);   Device: Surgical Mitral Valve Replacement (SMVR)
Sponsor:   Medtronic Cardiovascular
Recruiting

Early Psychological Intervention to Prevent Cardiovascular Event-Induced PTSD (REACH Sub-study)

Conditions:   Acute Coronary Syndrome;   TIA;   Stroke;   Cardiac Arrest;   PTSD
Intervention:   Behavioral: Written Exposure Therapy
Sponsors:   Columbia University;   National Center for PTSD
Active, not recruiting

Ticagrelor Versus Clopidogrel in Carotid Artery Stenting

Condition:   Carotid Artery Stenosis
Interventions:   Drug: Ticagrelor;   Drug: Clopidogrel;   Drug: Aspirin
Sponsor:   University Hospital, Basel, Switzerland
Recruiting

Tele-Rehabilitation Pilot Evaluation Study

Conditions:   Fractures, Bone;   Stroke;   Lower Limb Joint Replacement (Hip or Knee);   Lower Limb Amputation;   Pneumonia;   Fall;   Deconditioning;   Musculoskeletal Conditions (e.g., Tendinitis, Capsulitis)
Interventions:   Behavioral: Tele-rehabilitation;   Behavioral: Usual care
Sponsor:   National University, Singapore
Completed

The Effect of Hyperoxia on Cardiac Output

Conditions:   Hyperoxia;   Cardiac Output, Low
Intervention:   Other: Clearsight non-invasive cardiac index measurements
Sponsor:   Medical Centre Leeuwarden
Completed

Registry on WATCHMAN Outcomes in Real-Life Utilization WASP Registry

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boston Scientific Corporation
Completed

Safety and Efficacy Study of Lotus Valve for Transcatheter Aortic Valve Replacement (REPRISE Japan)

Condition:   Aortic Stenosis
Intervention:   Device: Lotus Valve System
Sponsor:   Boston Scientific Corporation
Active, not recruiting

REPRISE IV: LOTUS Edge Valve System in Intermediate Surgical Risk Subjects

Condition:   Aortic Valve Stenosis
Intervention:   Device: LOTUS Edge Valve System
Sponsor:   Boston Scientific Corporation
Recruiting

Brain Targets in Patients With Bladder Emptying Difficulties

Conditions:   Neurogenic Bladder;   Multiple Sclerosis;   Parkinson Disease;   Voiding Dysfunction
Intervention:   Device: Transcranial Rotating Permanent Magnet Stimulator (TRPMS)
Sponsors:   Rose Khavari, M.D.;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Minor Troponin Elevations in Patients With Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Myocardial Ischemia
Intervention:   Diagnostic Test: No intervention
Sponsor:   University of Turku
Active, not recruiting

A Randomized Comparison of CLOpidogrel Monotherapy Versus Extended Dual-antiplatelet Therapy Beyond 12 Months After Implantation of Drug-eluting StEnts in High-risk Lesions or Patients; A-CLOSE Trial

Conditions:   Coronary Artery Disease;   DES
Interventions:   Drug: Clopidogrel mono-therapy;   Drug: Dual-antiplatelet therapy
Sponsor:   Yonsei University
Recruiting

Observational Study to Confirm Safety and Efficacy of the ROADSAVER Stent for the Treatment of Carotid Artery Stenosis

Condition:   Carotid Artery Stenosis
Intervention:   Device: ROADSAVER
Sponsor:   Terumo Europe N.V.
Recruiting

Observational Trial of Cardiotoxicity in Patients Undergoing Chemotherapy.

Conditions:   Cardiotoxicity;   Heart Failure;   Dilated Cardiomyopathy
Interventions:   Diagnostic Test: Echocardiography with speckle tracking analysis.;   Diagnostic Test: 48-hour ECG monitoring.;   Diagnostic Test: Blood samples analysis.
Sponsor:   Moscow State University of Medicine and Dentistry
Recruiting

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Conditions:   Acute Coronary Syndrome;   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting

A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men ( TRAVERSE )

Conditions:   Hypogonadism;   Cardiovascular Diseases
Interventions:   Drug: Testosterone;   Drug: Placebo
Sponsors:   AbbVie;   Acerus Pharmaceuticals Corporation;   Allergan Sales, LLC;   Endo Pharmaceuticals;   Upsher-Smith Laboratories
Recruiting

Ketamine Versus Fentanyl for Induction of Anesthesia in Septic Shock

Condition:   Septic Shock
Interventions:   Drug: Ketamine;   Drug: Fentanyl;   Drug: Midazolam
Sponsor:   Cairo University
Recruiting

Effects of Remote Ischemic Pre-Conditioning in Moyamoya Disease Patients

Conditions:   Moyamoya Disease;   Remote Ischemic Preconditioning
Interventions:   Procedure: Remote ischemic preconditioning;   Procedure: Sham remote ischemic preconditioning;   Procedure: Encephaloduroarteriosynangiosis
Sponsors:   Beijing Tiantan Hospital;   Peking University International Hospital
Not yet recruiting

Effect of Efpeglenatide on Cardiovascular Outcomes

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Efpeglenatide (SAR439977);   Drug: Placebo
Sponsor:   Sanofi
Active, not recruiting

Single-session tDCS in Cerebral Palsy

Conditions:   Cerebral Palsy;   Perinatal Stroke;   Periventricular Leukomalacia
Interventions:   Device: Active tDCS;   Device: Sham tDCS
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer

Conditions:   Intractable Pain;   Palliative Care
Intervention:   Drug: Intrathecal Resiniferatoxin
Sponsors:   National Institute of Dental and Craniofacial Research (NIDCR);   National Institute of Neurological Disorders and Stroke (NINDS);   Sorrento Therapeutics, Inc.
Recruiting

Use of Anticoagulant, and Associated Factors of Anticoagulant Refusal Atrial Fibrillation Patients

Condition:   Atrial Fibrillation
Intervention:   Other: no intervention
Sponsor:   Prince of Wales Hospital, Shatin, Hong Kong
Not yet recruiting

Individualized Physical Activity and Carotid Plaque Instability

Condition:   Carotid Atherosclerosis
Interventions:   Device: individualized home-based physical activity;   Other: MRI;   Biological: blood sampling;   Other: Questionnaires;   Other: 6-minute walk test
Sponsor:   Hospices Civils de Lyon
Not yet recruiting

Cardiology Biobank Registry

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   Emory University
Recruiting

Study of the Relationship Between Body Composition, Insulin Resistance and HDL Levels

Conditions:   Obesity;   Insulin Resistance
Intervention:   Drug: Heparin
Sponsors:   University of California, Davis;   Dialysis Clinic, Inc.
Terminated

Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery

Conditions:   Acute Kidney Injury;   Post-Operative Delirium;   Icu Delirium;   Acute Renal Failure;   Delirium
Interventions:   Drug: atorvastatin;   Drug: placebo
Sponsor:   Vanderbilt University Medical Center
Completed

Incidence of Ascending Aortic Atheromatous

Condition:   Ascending Aortic Atheromatous Plaque
Intervention:   Diagnostic Test: epiaoryic scan
Sponsor:   Mahidol University
Recruiting

ISCHEMIA-Chronic Kidney Disease Trial

Conditions:   Cardiovascular Diseases;   Coronary Artery Disease;   Heart Diseases;   Myocardial Ischemia;   Kidney Disease;   End Stage Renal Failure on Dialysis
Interventions:   Procedure: Cardiac Catheterization;   Procedure: Coronary Artery Bypass Graft Surgery;   Procedure: Percutaneous Coronary Intervention;   Behavioral: Lifestyle;   Drug: Medication
Sponsors:   NYU Langone Health;   New York University;   National Heart, Lung, and Blood Institute (NHLBI);   Duke University;   Stanford University;   Columbia University
Active, not recruiting

The Effects of Renal Function and Atrial Fibrillation on Lipoproteins and Clot Structure/Function

Conditions:   Atrial Fibrillation;   Chronic Kidney Diseases
Interventions:   Drug: Warfarin;   Drug: Statin
Sponsors:   University of Liverpool;   Liverpool Centre for Cardiovascular Science;   Liverpool Heart and Chest Hospital NHS Foundation Trust;   Liverpool John Moores University;   University of Leeds
Not yet recruiting

ATTR Amyloidosis in Elderly Patients With Aortic Stenosis

Conditions:   Aortic Stenosis Symptomatic;   Amyloidosis Cardiac
Intervention:   Diagnostic Test: Tc-99m-DPD scintigraphy
Sponsor:   University Hospital Inselspital, Berne
Recruiting

Hepatitis C Treatment and Atherosclerosis

Conditions:   Chronic Hepatitis C;   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

The Maintenance of Human Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Arrhythmias, Cardiac
Intervention:  
Sponsors:   University of California, San Diego;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Genetic Factors in Atherosclerosis

Condition:   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Completed

Efficacy of Brisk Walking in Parkinson's Disease

Condition:   Parkinson Disease
Interventions:   Behavioral: Brisk walking and balance training;   Behavioral: Upper limb exercise
Sponsor:   The Hong Kong Polytechnic University
Recruiting

Improved Cardiovascular Risk Reduction to Enhance Rural Primary Care

Conditions:   Diabetes Mellitus;   Hypertension;   Coronary Artery Disease;   Atrial Fibrillation;   Stroke
Interventions:   Other: PHCVRS Intervention;   Other: Personal Health Record
Sponsor:   Korey Kennelty
Completed

Glycocalyx Levels in Patients Undergoing Pancreatectomy

Conditions:   Endothelial Degeneration;   Pancreatic Cancer;   Pancreatectomy;   Postoperative Pancreatic Fistula
Interventions:   Other: human albumin 5%;   Other: gelofusine.
Sponsor:   University of Malaya
Not yet recruiting

Effects of tDCS on Verbal Short-term Memory in PPA

Conditions:   Primary Progressive Aphasia;   Mild Cognitive Impairment;   Frontotemporal Dementia
Interventions:   Device: Anodal tDCS + vSTM therapy;   Device: Sham + short-term memory therapy
Sponsors:   Johns Hopkins University;   National Institutes of Health (NIH);   National Institute on Deafness and Other Communication Disorders (NIDCD)
Not yet recruiting

Automated Extracranial Internal Carotid Artery Ultrasound Sensor for Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Intervention:   Device: Automated extracranial internal carotid artery ultrasound sensor
Sponsor:   University of Michigan
Withdrawn

Impact of Peripheral Vascular Stiffness Assessment on Risk Prediction in Patients With Myocardial Infarction

Conditions:   Myocardial Infarction;   Vascular Stiffness;   Heart Failure
Intervention:   Other: Imaging evaluation for vascular assessment
Sponsors:   University Hospital, Lille;   Fédération Française de Cardiologie;   Merck Sharp & Dohme Corp.
Not yet recruiting

Metabolic Causes of Thrombosis in Type 2 Diabetes Mellitus

Condition:   Type 2 Diabetes
Interventions:   Procedure: euinsulinemic euglycemic glucose clamp;   Procedure: euinsulinemic hyperglycemic glucose clamp;   Procedure: Hyperinsulinemic euglycemic glucose clamp;   Procedure: Hyperinsulinemic hyperglycemic glucose clamp
Sponsors:   University of Maryland, Baltimore;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Condition:   Hypertension
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

Pathological Basis of MRI Signal Changes in Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Lithium Treatment for Patients With Spinocerebellar Ataxia Type I

Condition:   Spinocerebellar Ataxia Type I
Intervention:   Drug: Lithium Carbonate
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Biology of Cerebral Arteriovenous Malformations and Prognosis of Cerebral Arteriovenous Malformations

Conditions:   Cerebral Arteriovenous Malformations;   Ruptured or Unruptured Cerebral Arteriovenous Malformations
Intervention:  
Sponsor:   Fondation Ophtalmologique Adolphe de Rothschild
Recruiting

PMZ-1620 (Sovateltide) in Patients of Acute Spinal Cord Injury

Condition:   Acute Spinal Cord Injury
Interventions:   Drug: Normal Saline along with standard treatment;   Drug: PMZ-1620 along with standard treatment
Sponsor:   Pharmazz, Inc.
Recruiting

A Research Study of How Semaglutide Works in People With Disease Affecting the Heart and/or Blood Vessels and Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

Brain Stimulation and Aphasia Treatment

Condition:   Aphasia
Interventions:   Device: Activa Dose II Real tDCS;   Device: Activa Dose II Sham tDCS
Sponsors:   University of South Carolina;   National Institute on Deafness and Other Communication Disorders (NIDCD);   Medical University of South Carolina
Completed

Diagnosis and Management of Arterial Hypertension for Algerian Patients in Current Medical Practice

Condition:   Arterial Hypertension
Intervention:  
Sponsors:   Merinal Laboratoires;   Axelys Sante Dz
Completed

The Effect of Adding Exercise Training to Optimal Therapy in PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Other: Exercise therapy
Sponsor:   National Health Service, United Kingdom
Completed

Oral Anticoagulation in Haemodialysis Patients

Condition:   Kidney Failure, Chronic
Interventions:   Biological: No oral anticoagulation;   Drug: Oral anticoagulation with vitamin K antagonists
Sponsor:   University Hospital, Strasbourg, France
Recruiting

Mechanisms of Cerebrovascular Control

Condition:   Metabolic Syndrome X
Interventions:   Drug: NOS Inhibition;   Drug: ET-1 Inhibition;   Drug: NOS Inhibition Placebo;   Device: 3 Tesla MRI;   Device: Intravenous Catheter;   Other: Oral Glucose Tolerance Test;   Drug: ET-1 Inhibition Placebo
Sponsor:   University of Wisconsin, Madison
Recruiting

Efficacy of PMZ-2010 (Centhaquine) a Resuscitative Agent for Hypovolemic Shock

Condition:   Hypovolemic Shock
Interventions:   Drug: Normal saline + Standard Treatment;   Drug: Centhaquine + Standard Treatment
Sponsor:   Pharmazz, Inc.
Recruiting

Estimated Oxygen Extraction Versus Dynamic Parameters for Perioperative Hemodynamic Optimization

Conditions:   Perioperative/Postoperative Complications;   Morality
Interventions:   Diagnostic Test: Dynamic parameters of fluid responsiveness protocol;   Diagnostic Test: Estimated oxygen extraction protocol
Sponsor:   Università Politecnica delle Marche
Not yet recruiting

Comparison of Platelet Rich Plasma and Alternative Therapies for the Treatment of Tennis Elbow (Lateral Epicondylitis)

Condition:   Lateral Epicondylitis (Tennis Elbow)
Interventions:   Other: Platelet Rich Plasma (PRP) Injection;   Other: Whole Blood Injection;   Other: Dry Needle Fenestration;   Other: Sham Injection
Sponsors:   McMaster University;   Arthrex, Inc.;   The Physicians' Services Incorporated Foundation;   Radiological Society of North America
Active, not recruiting

MiSaver® Stem Cell Treatment for Heart Attack (Acute Myocardial Infarction)

Condition:   Myocardial Infarction
Intervention:   Biological: MiSaver®
Sponsors:   Honya Medical Inc;   Chung Shan Medical University
Recruiting

Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID)-2.0

Condition:   Hypertension
Intervention:  
Sponsors:   National Human Genome Research Institute (NHGRI);   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome

Condition:   Antiphospholipid Syndrome
Intervention:  
Sponsor:   Duke University
Recruiting

Does Walking Performance Improve When Veterans With Leg Amputations Are Given Visual Feedback?

Condition:   Amputation
Interventions:   Device: Passive-elastic prosthetic foot;   Device: Powered ankle-foot prosthesis
Sponsor:   VA Office of Research and Development
Recruiting

Obstructive Sleep Apnea, CPAP Treatment & Cognitive Ability in HIV

Conditions:   Hiv;   Obstructive Sleep Apnea;   Cognitive Change
Intervention:   Behavioral: CPAP intervention
Sponsors:   McGill University;   Vitalaire;   ResMed
Enrolling by invitation

Hybrid Therapy and Heart Team for Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Procedure: Hybrid ablation;   Procedure: Percutaneous catheter ablation
Sponsors:   University Hospital, Toulouse;   AtriCure, Inc.
Recruiting

SubArachnoid Hemorrhage HEadache Treated by Lumbar Puncture

Conditions:   Aneurysmal Subarachnoid Hemorrhage;   Headache
Intervention:   Procedure: Lumbar puncture
Sponsor:   University Hospital, Toulouse
Recruiting

The Effect of Glucocorticoid Therapy on Left Ventricular Remodelling in Acute Myocardial Infarction (RECONSIDER)

Conditions:   ST-segment Elevation Myocardial Infarction;   Left Ventricular Remodeling
Interventions:   Drug: Hydrocortisone;   Drug: Placebo
Sponsors:   Iuliu Hatieganu University of Medicine and Pharmacy;   Romanian Governmental Funding (UEFISCDI)
Recruiting

Middle Meningeal Artery Embolization for Chronic Subdural Hematoma

Condition:   Chronic Subdural Hematoma
Interventions:   Procedure: Middle Meningeal Artery Embolization with polyvinyl alcohol particles (PVA);   Procedure: Drainage of Subdural Hematoma
Sponsor:   Washington University School of Medicine
Recruiting

Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas

Condition:   Low-grade Glioma
Interventions:   Device: ReMind iPad app;   Device: Healthy SMS texting;   Behavioral: In-person cognitive rehabilitation
Sponsors:   University of California, San Francisco;   University of Tilburg;   University of California, Berkeley
Recruiting

Redefining Survivorship: POWER to Maximize Physical Function for Survivors of Critical Illness

Conditions:   Critical Illness;   Muscle Atrophy or Weakness
Intervention:   Other: Power training
Sponsors:   University of Kentucky;   Nathan Johnson, PT, PhD;   Ashley Montgomery-Yates, MD;   Amy Pastva, PT, PhD;   Peter E. Morris, MD
Not yet recruiting

Effects of Nocturnal Nasal Oxygen on Biomarkers in Sleep Apnea Patients With Heart Failure

Conditions:   Sleep Apnea;   Heart Failure
Interventions:   Procedure: Nocturnal nasal oxygen;   Other: No nasal oxygen
Sponsor:   University of Maryland, Baltimore
Terminated

BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity

Conditions:   Pediatrics;   Muscle Spasticity;   Cerebral Palsy;   Stroke
Intervention:   Biological: Botulinum Toxin Type A
Sponsor:   Allergan
Completed

Telerehabilitation for Cognitive Impairment Following Acquired Brain Injury

Conditions:   Cognitive Dysfunction;   Brain Injuries
Intervention:   Device: Virtual reality game
Sponsor:   Hull and East Yorkshire Hospitals NHS Trust
Not yet recruiting

Mobility Training to Improve Motor Behavior in Toddlers With or at Risk for Cerebral Palsy: A Pilot Study

Conditions:   Developmental Delay;   Cerebral Palsy
Intervention:   Behavioral: mobility training with dynamic body weight support
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed

Apogee, A HeartWare HVAD Destination Product Surveillance Registry (PSR) Platform

Condition:   Chronic Heart Failure
Intervention:   Device: HeartWare Ventricular Assist Device
Sponsor:   Medtronic Cardiac Rhythm and Heart Failure
Recruiting

Effects of Rapid-Resisted Exercise and Bright Light Therapy on Ambulatory Adults With Traumatic Brain Injury

Conditions:   Adult;   Traumatic Brain Injury;   fMRI
Interventions:   Other: Exercise;   Other: Mood Therapy
Sponsors:   National Institutes of Health Clinical Center (CC);   Center for Neuroscience and Regenerative Medicine (CNRM);   Henry M. Jackson Foundation for the Advancement of Military Medicine;   United States Department of Defense
Completed

Apogee International

Condition:   Chronic Heart Failure
Intervention:   Device: HeartWare Ventricular Assist Device
Sponsor:   Medtronic Cardiac Rhythm and Heart Failure
Not yet recruiting

An Urban Trail Network and Cardiovascular Disease: A Natural Experiment

Conditions:   Cardiovascular Diseases;   Cardiovascular Risk Factor;   Diabetes Mellitus
Intervention:   Other: Urban Trail
Sponsors:   University of Manitoba;   St. Michael's Hospital, Toronto;   Ontario Agency for Health Protection and Promotion;   University of Toronto
Recruiting

Genotyping GUided Antiplatelet theRapy in pAtieNts Treated With Drug Eluting stEnts (GUARANTEE)

Conditions:   Angina, Stable;   Acute Coronary Syndrome;   Drug-Eluting Stents;   Genotype
Intervention:   Genetic: CYP2C19 genotype testing
Sponsor:   Beijing Anzhen Hospital
Recruiting

BeSingCardioRehab: CR in Belgium Versus Singapore

Condition:   Ischemic Heart Disease
Intervention:   Other: Cardiac Rehabilitation
Sponsors:   Hasselt University;   Jessa Hospital
Recruiting

MitralStitch Mitral Valve Repair System for Mitral Regurgitation

Condition:   Mitral Regurgitation
Intervention:   Device: MitralStitch
Sponsor:   Xijing Hospital
Enrolling by invitation

Efficacy and Safety of Implantable Cardioverter-Defibrillator (ICD) Implantation in the Elderly

Conditions:   Cardiomyopathy;   Coronary Artery Disease;   Congestive Heart Failure;   Myocardial Infarction
Interventions:   Device: Implantable Cardioverter Defibrillator;   Other: Optimal Medical Therapy
Sponsor:   VA Office of Research and Development
Recruiting

Clinical Evaluation of a Modular Extracorporeal Circulation Circuit

Conditions:   Coronary Artery Disease;   Aortic Valve Disease;   Mitral Valve Disease;   Aortic Aneurysm
Intervention:   Device: Modular Cardiopulmonary Bypass Circuit
Sponsor:   AHEPA University Hospital
Recruiting

Comparative Effectiveness of Empagliflozin in the US

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Empagliflozin;   Drug: DPP-4 inhibitor
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting

Efficacy and Safety of Adjunctive Cilostazol in Acute Myocardial Infarction Patients

Condition:   Acute Myocardial Infarction
Intervention:   Drug: antiplatelet therapy
Sponsor:   Korea University Guro Hospital
Recruiting

Brain Imaging for HIV-Associated Thinking and Mood Disorders

Conditions:   Human Immunodeficiency Virus;   Neurocognitive Impairment
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Allergy and Infectious Diseases (NIAID)
Terminated

ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair.

Conditions:   Abdominal Aortic Aneurysm;   Surgery;   Arterial Disease
Intervention:   Drug: ACT guided heparinization
Sponsors:   Westfriesgasthuis;   ZonMw: The Netherlands Organisation for Health Research and Development;   VU University Medical Center;   AIDS Malignancy Consortium
Not yet recruiting

The Effect of Myofascial Induction and Therapeutic Pain Training in Chronic Low Back Pain

Condition:   Back Pain
Interventions:   Other: Myofascial induction therapy;   Other: Therapeutic pain education
Sponsor:   Medipol University
Not yet recruiting

Clinical Presentation and Outcomes in Patients at Risk of Type II Myocardial InfarctioN in the emerGency Department.

Conditions:   Myocardial Oxygenation Imbalance;   Myocardial Infarction
Intervention:   Other: Follow-up
Sponsor:   Hospices Civils de Lyon
Recruiting

Early Feasibility Study of the RelayBranch Thoracic Stent-Graft System

Conditions:   Thoracic Aorta Aneurysm;   Aneurysm, Ruptured;   Aortic Aneurysm
Intervention:   Device: penetrating atherosclerotic ulcer, aorta branch cardiovascular implant
Sponsor:   Bolton Medical
Recruiting

Effects of the Application of a Reflex Locomotion Program in the Neurological Hand

Condition:   Neurological Disorder
Intervention:   Other: Reflex locomoction therapy
Sponsor:   NUMEN Foundation
Recruiting

Citadel Feasibility Study

Condition:   Unruptured Wide-neck Aneurysms
Intervention:   Device: Citadel Embolization Device
Sponsor:   Stryker Neurovascular
Enrolling by invitation

Atrial Fibrillation Ablation Registry

Condition:   Atrial Fibrillation
Intervention:   Device: Atrial Fibrillation Ablation
Sponsor:   Hoag Memorial Hospital Presbyterian
Recruiting

rTMS in Treatment of Spasticity

Condition:   ALS
Intervention:   Device: Mag Stim
Sponsor:   Hospital for Special Surgery, New York
Recruiting

Efficacy of Optison Echo Contrast to Detect Thrombus in Left Atrial Appendage

Condition:   Atrial Fibrillation
Intervention:   Drug: Optison echocardiography contrast agent
Sponsor:   University of Utah
Completed

The Effects of Swimming on Elderly Women With Stage-2 Hypertension

Conditions:   Menopause;   Hypertension
Intervention:   Behavioral: Swimming
Sponsor:   University of Nebraska, Omaha
Completed

Real-life Clinical Outcomes of Direct Oral Anticoagulants (MACACOD)

Conditions:   Atrial Fibrillation;   Recurrent Venous Thromboembolism
Intervention:   Drug: dabigatran, rivaroxaban, apixaban or edoxaban
Sponsors:   Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau;   Daiichi Sankyo, Inc.
Recruiting

FFR-CT to Detect the Absence of Hemodynamically Significant Lesions in Patients With High-risk Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Diagnostic Test: FFR-CT;   Diagnostic Test: FFRangio™
Sponsor:   Centre Hospitalier Universitaire Vaudois
Not yet recruiting

Multicentre Study of MITRACLIP® Transcatheter Mitral Valve Repair in Patients With Severe Primary Mitral Regurgitation Eligible for High-risk Surgery

Condition:   Mitral Regurgitation
Interventions:   Device: percutaneous mitral valve repair with MITRACLIP NT;   Procedure: cardiac surgery
Sponsors:   Nantes University Hospital;   Ministère de la Santé;   Abbott
Recruiting

EVAS2 IDE Prospective, Multicenter, Single Arm Safety and Effectiveness Confirmatory Study

Condition:   Abdominal Aortic Aneurysm Without Rupture
Intervention:   Device: Nellix® System
Sponsor:   Endologix
Recruiting

Correlation of Artherosclerotic Plaque Volume and Intima Media Thickness With Soluble P-selectin

Conditions:   Cardiovascular Risk Factors;   Coronary Artery Disease;   Cerebrovascular Disease;   Peripheral Artery Disease
Intervention:  
Sponsor:   Medical University Innsbruck
Active, not recruiting

Treatment of Heart Failure and Associated Functional Mitral Valve Regurgitation

Condition:   Mitral Valve Regurgitation
Intervention:   Device: ARTO System
Sponsor:   Mvrx, Inc.
Recruiting

Endothelial Function Guided Therapy in Patients With Non-obstructive Coronary Artery Disease

Condition:   Non-obstructive Coronary Artery Disease
Intervention:   Other: Endothelial function guided therapy
Sponsors:   Peking University;   Mayo Clinic;   Peking University Shougang Hospital
Recruiting

Study of Transcatheter Tricuspid Annular Repair

Condition:   Tricuspid Regurgitation
Interventions:   Device: MIA, Minimally Invasive Annuloplasty Device - Surgical;   Device: MIA, Minimally Invasive Annuloplasty Device - Percutaneous
Sponsor:   Micro Interventional Devices
Recruiting

Aortic Replacement Using Individualised Regenerative Allografts - ARISE (the "Surveillance")

Condition:   Heart Valve Disease
Intervention:   Other: Decellularized human heart valves
Sponsors:   corlife;   Hannover Medical School;   Leiden University Medical Center;   Azienda Ospedaliera di Padova;   Hospital Clinic of Barcelona;   Royal Brompton & Harefield NHS Foundation Trust;   Universitaire Ziekenhuizen Leuven;   Heinrich-Heine University, Duesseldorf;   Vienna General Hospital
Completed

Clinical Trial to Improve the Magnetic Levator Prosthesis

Conditions:   Blepharoptosis;   Ptosis, Eyelid;   Myasthenia Gravis;   Stroke;   Traumatic Brain Injury
Intervention:   Device: Magnetic Levator Prosthesis (MLP)
Sponsor:   Massachusetts Eye and Ear Infirmary
Recruiting

INAS-FOCUS (International Active Surveillance Study - Folate in Oral Contraceptives Utilization Study)

Condition:   Contraception
Intervention:  
Sponsors:   Center for Epidemiology and Health Research, Germany;   Bayer
Active, not recruiting

Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI

Condition:   Acute Myocardial Infarction
Interventions:   Drug: LCZ696 (sacubitril/valsartan);   Drug: Ramipril;   Drug: Placebo of LCZ696;   Drug: Placebo of ramipril;   Drug: Valsartan;   Drug: Placebo of valsartan
Sponsor:   Novartis Pharmaceuticals
Recruiting

Effects of Passive Heat Therapy on Oxygen Consumption and Cardiovascular Fitness in Adults

Conditions:   Heart Failure;   Heart Diseases;   Cardiovascular Diseases;   Endothelial Dysfunction
Intervention:   Behavioral: Heat Therapy Treatment
Sponsors:   University of Kansas Medical Center;   National Institute of General Medical Sciences (NIGMS)
Not yet recruiting

Transcultural Validation of the Physical Activity Scale for Individuals With Physical Disabilities (PASIPD) in French: The PASIPD-Fr

Conditions:   Physical Disability;   Neurological Diseases or Conditions
Intervention:   Behavioral: PASIPD-Fr
Sponsor:   University Hospital, Caen
Completed

Right Ventricular Function at Rest in Highlanders/Lowlanders

Condition:   High Altitude Pulmonary Hypertension
Intervention:  
Sponsors:   University of Zurich;   National Center of Cardiology and Internal Medicine, Kyrgyzstan
Completed

Diet Treatment Glucose Transporter Type 1 Deficiency (G1D)

Conditions:   GLUT1DS1;   Epilepsy;   Glut1 Deficiency Syndrome 1, Autosomal Recessive;   Glucose Metabolism Disorders;   Glucose Transport Defect;   Glucose Transporter Type 1 Deficiency Syndrome;   Glucose Transporter Protein Type 1 Deficiency Syndrome
Intervention:   Drug: Triheptanoin
Sponsors:   University of Texas Southwestern Medical Center;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Safety of Autologous Stem Cell Treatment for Traumatic Brain Injury in Children

Condition:   Traumatic Brain Injury
Intervention:   Drug: Autologous bone marrow precursor cell harvest and transplant
Sponsor:   The University of Texas Health Science Center, Houston
Completed

Pediatric Autologous Bone Marrow Mononuclear Cells for Severe Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Interventions:   Biological: autologous bone marrow mononuclear cells;   Other: Placebo Infusion
Sponsors:   The University of Texas Health Science Center, Houston;   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation

Relating Genetic and Environmental Risk Scores to Multiple Sclerosis Susceptibility

Condition:   Multiple Sclerosis
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Preterm Erythropoietin Neuroprotection Trial (PENUT Trial)

Condition:   Extreme Prematurity
Interventions:   Drug: Epo;   Other: Control
Sponsors:   University of Washington;   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting

TactiSense IDE Trial of TactiCath SE for Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Intervention:   Device: TactiCath SE
Sponsor:   Abbott Medical Devices
Active, not recruiting

Effects of Tolcapone on Frontotemporal Dementia

Condition:   Frontotemporal Lobar Degeneration
Interventions:   Drug: Tolcapone;   Drug: Placebo
Sponsors:   Columbia University;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Diet and Exercise Frailty Intervention in Cardiac Device Patients

Conditions:   Frailty;   Cardiovascular Diseases
Intervention:   Other: Exercise and Nutritional Supplement
Sponsor:   Population Health Research Institute
Not yet recruiting

Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function

Condition:   Cerebral Small Vessel Diseases
Interventions:   Drug: Amlodipine;   Drug: Losartan;   Drug: Atenolol
Sponsors:   Ludwig-Maximilians - University of Munich;   University of Edinburgh;   Maastricht University Medical Center;   UMC Utrecht;   University of Oxford
Recruiting

Erigo®Pro Coma Outcome Study - Study on the Effectiveness of a Robotic Tilt Table Device for Recovery of Consciousness

Conditions:   Brain Injuries;   Disorders of Consciousness
Interventions:   Behavioral: Standard physiotherapy;   Device: Erigo®Pro group without FES;   Device: Erigo®Pro group with FES
Sponsors:   Ludwig-Maximilians - University of Munich;   Therapiezentrum Burgau
Completed

Effect of Acetazolamide on Right Ventricular Function at Rest in Patients With Respiratory Disease at Altitude

Condition:   Chronic Obstructive Pulmonary Disease
Interventions:   Drug: ACETAZOLAMIDE oral capsule;   Drug: Placebo oral capsule
Sponsors:   University of Zurich;   National Center of Cardiology and Internal Medicine, Kyrgyzstan
Completed

Efficacy and Safety Study of MYOBLOC® Followed by Open-Label Multiple-Treatment With MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adult Subjects

Condition:   Sialorrhea
Interventions:   Drug: MYOBLOC;   Other: PLACEBO
Sponsor:   US WorldMeds LLC
Completed

Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Conditions:   Mitral Regurgitation;   Mitral Insufficiency;   Mitral Valve Insufficiency;   Cardiovascular Diseases;   Valve Disease, Heart;   Heart Valve Diseases;   Functional Mitral Regurgitation;   Degenerative Mitral Valve Disease
Interventions:   Device: Tendyne Mitral Valve System;   Device: MitraClip System
Sponsor:   Tendyne Holdings, Inc.
Recruiting

BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

Conditions:   Tetraplegia;   Spinal Cord Injuries;   Amyotrophic Lateral Sclerosis;   Brain Stem Infarctions;   Locked in Syndrome;   Muscular Dystrophy
Intervention:   Device: Placement of the BrainGate2 sensor(s) into the motor-related cortex
Sponsors:   Leigh R. Hochberg, MD, PhD.;   National Institute on Deafness and Other Communication Disorders (NIDCD);   US Department of Veterans Affairs;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Changes in Digital Phenotype During PE Therapy

Condition:   PTSD
Intervention:  
Sponsor:   Nadav Goldental
Not yet recruiting

The Value of Screening for HPR in Patients Undergoing Lower Extremity Arterial Endovascular Interventions

Conditions:   Peripheral Artery Disease;   Clopidogrel, Poor Metabolism of;   Peripheral Vascular Disease;   Artery Disease;   Peripheral Arterial Occlusive Disease
Interventions:   Diagnostic Test: Point of care screening for HPR;   Drug: Ticagrelor 90mg
Sponsor:   Kyle Markel
Recruiting

LOwer Maintenance Dose TICagrelor in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention

Conditions:   Antiplatelet Therapy;   Coronary Artery Disease;   Percutaneous Coronary Intervention
Interventions:   Drug: Ticagrelor 90mg;   Drug: Ticagrelor 90mg/60mg;   Drug: Clopidogrel 75mg
Sponsor:   Beijing Anzhen Hospital
Not yet recruiting

Association of PeriOPerative Aspirin-ResisTance and CardioVascular Outcome

Condition:   Vascular Surgery
Intervention:  
Sponsor:   University Hospital Heidelberg
Not yet recruiting

Comparison of Minimal Versus Conventional Extracorporeal Circulation in Coronary Surgery

Condition:   Coronary Artery Bypass
Interventions:   Procedure: Coronary artery bypass grafting with the use of minimal invasive extracorporeal circulation;   Procedure: Coronary artery bypass grafting under conventional extracorporeal circulation
Sponsor:   AHEPA University Hospital
Active, not recruiting

Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study

Conditions:   Spinal Cord Injuries;   Traumatic Brain Injury;   Spina Bifida;   Cerebral Palsy;   Stroke;   Parkinson Disease;   Multiple Sclerosis
Intervention:   Other: Movement-2-Music (M2M)
Sponsors:   University of Alabama at Birmingham;   Lakeshore Foundation;   YMCA of Greater Birmingham
Recruiting

Functional Exercise and Nutrition Education Program for Older Adults

Conditions:   Chronic Disease;   Frail;   Diabetes Mellitus;   Cancer;   Chronic Lung Disease;   Cardiovascular Diseases;   Congestive Heart Failure;   Hypertension;   Osteoporosis, Osteopenia;   Arthritis;   Stroke;   Kidney Diseases
Interventions:   Other: Strength and Balance Training & Nutrition Education;   Other: Usual Care
Sponsors:   University of Waterloo;   Canadian Institutes of Health Research (CIHR);   City of Lakes family Health Team;   Schlegel Villages and Research Institute for Aging;   YMCA;   Kinnect to Wellness
Not yet recruiting

Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions

Conditions:   Orthopedic Disorder;   Neurologic Disorder;   Urologic Diseases;   Erectile Dysfunction;   Autoimmune Diseases;   Renal Failure;   Renal Insufficiency;   Kidney Diseases;   Cardiac Event;   Cardiomyopathies;   CHF;   Pulmonary Disease;   COPD;   Alzheimer Disease;   Stroke;   Neuropathy;Peripheral;   Arthritis
Intervention:   Biological: Amniotic and Umbilical Cord Tissue Procedure
Sponsor:   R3 Stem Cell
Not yet recruiting

Adherence to LPV in SICU and Associated Clinical Outcomes

Conditions:   Adult;   Guideline Adherence;   Humans;   Intensive Care Units;   Perioperative/Postoperative Complications;   Respiration, Artificial;   Tidal Volume
Intervention:  
Sponsor:   Mahidol University
Active, not recruiting

Neurobiological Analyses Within the FORESEE III Study

Condition:   Treatment Resistant Depression
Intervention:  
Sponsors:   University Hospital Freiburg;   German Center for Neurodegenerative Diseases (DZNE);   University Medical Center Freiburg;   University Hospital, Bonn
Recruiting

Study to Develop a Prediction Model to Understand the Effect of Low-dose Aspirin on Cancer That Develops in the Colon and/or the Rectum, Diseases That Affects the Heart or Blood Vessels and Safety Outcomes in European Countries. The Study is Also Called PEACOS Model EU

Conditions:   Colorectal Cancer;   Cardiovascular Disease;   Bleeding
Intervention:   Drug: Acetylsalicylic Acid (Aspirin, BAYE4465)
Sponsor:   Bayer
Active, not recruiting

accuRate Evaluation of Benefit With Optimal Medical Treatment With or With-Out Transcatheter Valve Repair of PARADOXical Low Flow Low Gradient Aortic Stenosis - REBOOT-PARADOX

Condition:   Aortic Valve Stenosis
Intervention:   Device: TAVR
Sponsors:   IHF GmbH - Institut für Herzinfarktforschung;   Boston Scientific Group;   Yale University
Recruiting

Comparison of Aortic Stenosis Subtypes After Balloon Aortic Valvuloplasty

Condition:   Aortic Valve Stenosis
Interventions:   Procedure: BAV;   Procedure: BAV + TAVR
Sponsor:   Heinrich-Heine University, Duesseldorf
Active, not recruiting

MyoVasc Study on the Development and Progression of Heart Failure

Condition:   Heart Failure
Intervention:  
Sponsor:   Johannes Gutenberg University Mainz
Active, not recruiting

POTS NET mRNA Functional Correlation With NET Activity

Condition:   Postural Tachycardia Syndrome
Interventions:   Diagnostic Test: NET mRNA level;   Diagnostic Test: Plasma catechols;   Diagnostic Test: Urine Catechols
Sponsors:   Vanderbilt University Medical Center;   National Institute of Neurological Disorders and Stroke (NINDS);   University of Calgary;   Dysautonomia International
Enrolling by invitation

Implantable Cardiac Monitors in High-Risk Post-Infarction Patients With Cardiac Autonomic Dysfunction

Conditions:   Myocardial Infarction;   Autonomic Nervous System Diseases
Intervention:   Device: Medtronic Reveal LINQ implantable cardiac monitor
Sponsors:   Klinikum der Universitaet Muenchen;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK);   Medtronic Bakken Research Center
Recruiting

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients

Conditions:   Intracranial Aneurysm;   Brain Edema;   Scoliosis;   Surgery
Interventions:   Drug: Phenylephrine;   Drug: Epinephrine;   Other: Albumin;   Other: Voluven;   Other: Normal Saline;   Other: Packed Red Blood Cells;   Device: FloTrac Monitor
Sponsor:   NYU Langone Health
Completed

Efficacy and Safety of AMG0001 in Subjects With Critical Limb Ischemia

Condition:   Critical Limb Ischemia
Interventions:   Biological: HGF Plasmid (AMG0001);   Biological: Matching Placebo
Sponsor:   AnGes USA, Inc.
Terminated

Autologous Adipose Derived MSC (HB-adMSC) for Sub-Acute and Chronic Neurological Injury

Condition:   Traumatic Brain Injury
Intervention:   Drug: autologous adipose derived mesenchymal stem cells (HB-adMSC)
Sponsors:   Hope Biosciences;   The University of Texas Health Science Center, Houston
Not yet recruiting

Transpacific TAVR Registry

Conditions:   Heart Valve Diseases;   Aortic Valve Insufficiency
Intervention:   Procedure: TAVR
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea
Recruiting

Brain Stimulation and Hand Training in Children With Hemiparesis

Condition:   Pediatric Hemiparesis
Interventions:   Device: Transcranial Direct Current Stimulation (tDCS);   Device: Placebo Comparator
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Cerebral Palsy International Research Foundation;   Foundation for Physical Therapy, Inc.;   NIH K01 Career Development Award
Active, not recruiting

Nickel Sensitivity

Conditions:   Knee Arthropathy;   Allergic Reaction
Interventions:   Device: TKA with nickel free components;   Device: TKA with standard cobalt chromium components
Sponsor:   Rush University Medical Center
Not yet recruiting

IVUS Assessment of Atheroma Burden After Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   University Hospital, Toulouse
Recruiting

Use of Mobile App to Enhance Geriatric Hip Fracture Rehabilitation

Conditions:   Hip Fractures;   Rehabilitation
Intervention:   Procedure: Home-based rehabilitation program using mobile app
Sponsors:   Hospital Authority, Hong Kong;   The Hong Kong Polytechnic University
Not yet recruiting

Nanowear Heart Failure Management Multi-sensor Algorithm

Condition:   Heart Failure
Intervention:   Device: SimpleSENSE
Sponsors:   Nanowear Inc.;   Milton S. Hershey Medical Center;   Hackensack Meridian Health
Recruiting

Comparison of Oral Anticoagulants for Extended VEnous Thromboembolism

Condition:   Venous Thromboembolism
Interventions:   Drug: Warfarin;   Drug: Apixaban 2.5 MG;   Drug: Rivaroxaban 10 MG
Sponsors:   Duke University;   Patient-Centered Outcomes Research Institute
Terminated

Management and Clinical Outcomes of Patients With Severe Mitral Valve Disease Not Suitable for Surgery

Condition:   Mitral Valve Disease
Intervention:  
Sponsor:   French Cardiology Society
Recruiting

Prolonged Enoxaparin in Primary Percutaneous Coronary Intervention

Condition:   Myocardial Infarction
Intervention:   Drug: Enoxaparin
Sponsors:   Sheffield Teaching Hospitals NHS Foundation Trust;   Medical Research Council
Recruiting

Metabolomic Analysis of Systemic Sclerosis

Conditions:   Scleroderma (Limited and Diffuse);   Undifferentiated Connective Tissue Disease;   Raynaud Disease;   Vascular Disease;   Healthy Control Subjects
Intervention:   Procedure: - Skin biopsy - Urine sample - Blood sample
Sponsor:   University Hospital, Strasbourg, France
Recruiting

Different Antiplatelet Therapy Strategy After Coronary Artery Bypass Graft Surgery

Conditions:   Coronary Artery Bypass;   Antiplatelet Agents
Interventions:   Drug: Aspirin;   Drug: Ticagrelor
Sponsor:   Ruijin Hospital
Completed

HeAlth-data Register sTudies of Risk and Outcomes in Cardiac Surgery

Conditions:   Cardiovascular Diseases;   Kidney Diseases;   Depression;   Diabetes Mellitus
Interventions:   Procedure: Coronary artery bypass surgery;   Procedure: Heart valve surgery
Sponsors:   Ulrik Sartipy, MD, PhD;   Karolinska Institutet
Active, not recruiting

Risk of Oxygen During Cardiac Surgery Trial

Condition:   Cardiac Surgery
Intervention:   Drug: Oxygen
Sponsors:   Vanderbilt University;   National Institute of General Medical Sciences (NIGMS)
Recruiting

Determination of CRIM Status and Longitudinal Follow-up of Individuals With Pompe Disease

Condition:   Pompe Disease
Intervention:   Other: Observational
Sponsors:   Duke University;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

[Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients]

Conditions:   Vasoplegic Syndrome;   Liver Transplant; Complications
Interventions:   Drug: Hydroxocobalamin;   Drug: Methylene Blue
Sponsor:   Mayo Clinic
Not yet recruiting

Do Combinatorial Training Lead to Better Cognition and Daily Participation in TBI Persons With Cognitive Impairments

Conditions:   Trauma, Brain;   Cognitive Deficit
Interventions:   Procedure: aerobic exercise training;   Procedure: computerized cognitive training;   Procedure: guiding training
Sponsor:   Chang Gung Memorial Hospital
Not yet recruiting

A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)

Condition:   Systemic Sclerosis-Associated PAH
Interventions:   Biological: Rituximab;   Other: Placebo;   Diagnostic Test: CMRI;   Drug: prednisone;   Drug: methylprednisolone;   Drug: diphenhydramine;   Drug: acetaminophen
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Autoimmunity Centers of Excellence
Active, not recruiting

Efficacy of Subintimal vs Intraluminal Approach for Atherosclerotic Chronic Occlusive Femoropopliteal Arterial Disease

Conditions:   Peripheral Arterial Disease;   Atherosclerosis
Interventions:   Procedure: Intentional intraluminal approach;   Procedure: Intentional subintimal approach
Sponsor:   Korea University Guro Hospital
Recruiting

MRS to Determine Neuroinflammation and Oxidative Stress in MPS I

Condition:   Mucopolysaccharidosis Type I
Intervention:  
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   Lysosomal Disease Network
Active, not recruiting

Open-Label Extension and Safety Study for Patients With Crohn's Disease Previously Enrolled in the Etrolizumab Phase III Study GA29144

Condition:   Crohn Disease
Intervention:   Drug: etrolizumab
Sponsor:   Hoffmann-La Roche
Recruiting

A Study to Assess Whether Etrolizumab is a Safe and Effective Treatment for Participants With Moderately to Severely Active Crohn's Disease (CD)

Condition:   Crohn Disease
Interventions:   Drug: Etrolizumab;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Recruiting

Evaluate the Safety and Explore Efficacy of Umbilical Cord Mesenchymal Stem Cells in Acute Myocardial Infarction

Condition:   Acute Myocardial Infarction
Intervention:   Biological: Allogeneic umbilical cord mesenchymal stem cells
Sponsor:   Ever Supreme Bio Technology Co., Ltd.
Recruiting

A Clinical Trial Comparing Efficacy and Safety of Dabigatran Etexilate With Warfarin in Patients With Cerebral Venous and Dural Sinus Thrombosis (RE-SPECT CVT)

Condition:   Thromboembolism
Interventions:   Drug: Dabigatran etexilate;   Drug: Warfarin
Sponsor:   Boehringer Ingelheim
Completed

Vision Testing in Patients With Partial Seizures Receiving Either Lyrica or Placebo

Condition:   Epilepsies, Partial
Interventions:   Drug: Lyrica (pregabalin);   Drug: placebo
Sponsor:   Pfizer
Recruiting

Trial of Andexanet in ICH Patients Receiving an Oral FXa Inhibitor

Condition:   Acute Intracranial Hemorrhage
Intervention:   Drug: andexanet alfa
Sponsors:   Portola Pharmaceuticals;   Population Health Research Institute
Recruiting

Impact of Neutrophil Extracellular Traps (NET) on Thrombolysis in Acute Phase of Cerebral Ischemia

Condition:   Cerebral Infarct
Intervention:  
Sponsor:   Hopital Foch
Completed

Effects of Whole Body Vibration Training in Patients With Interstitial Lung Disease

Conditions:   Interstitial Lung Disease;   Scleroderma;   Idiopathic Pulmonary Fibrosis
Intervention:   Other: Whole Body Vibration Training
Sponsor:   Istanbul University
Active, not recruiting

Safety and Efficacy of the SurVeil™ Drug-Coated Balloon

Conditions:   Peripheral Arterial Disease;   Peripheral Vascular Disease;   Artery Disease, Peripheral;   Femoropopliteal Artery Occlusion
Interventions:   Device: Surmodics SurVeil DCB;   Device: Medtronic IN.PACT Admiral DCB
Sponsor:   SurModics, Inc.
Recruiting

Laser Ablation Versus Mechanochemical Ablation Trial

Condition:   Varicose Veins
Interventions:   Device: EVLA;   Device: ClariVein®;   Drug: Lidocaine with 1:200,000 epinephrine solution;   Drug: Sodium Bicarbonate;   Drug: Sodium Tetradecyl Sulphate
Sponsor:   Hull and East Yorkshire Hospitals NHS Trust
Active, not recruiting

Improving Self-care of Heart Failure Caregivers

Condition:   Heart Failure
Intervention:   Behavioral: ViCCY
Sponsor:   University of Pennsylvania
Recruiting

Personalized Activity Intervention in Rehabilitation After Cardiac Operations (the PACO Trial)

Conditions:   Coronary Artery Disease;   Aortic Valve Stenosis;   Mitral Valve Insufficiency
Interventions:   Behavioral: PACO intervention for CABG patients;   Behavioral: PACO intervention for AVR patients;   Behavioral: PACO intervention for MVR patients
Sponsors:   Kuopio University Hospital;   UKK Institute;   Turku University Hospital
Recruiting

Slow and Deep Breathing to Lower Blood Pressure in Women With Pregnancy-induced Hypertension

Condition:   Pregnancy-Induced Hypertension
Intervention:   Other: Slow and deep breathing
Sponsor:   Bournemouth University
Not yet recruiting

Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.

Condition:   Acute Kidney Injury
Interventions:   Drug: Nitric Oxide;   Other: Placebo
Sponsors:   Massachusetts General Hospital;   Ichinose, Fumito, M.D., Ph.D., Massachusetts General Hospital;   Kenneth, Shelton, M.D., Massachusetts General Hospital;   Kacmarek, Robert M., Ph.D., Massachusetts General Hospital;   Sundt, Thoralf M., M.D., Massachusetts General Hospital;   Villavicencio-Theoduloz, Mauricio A., M.D., Massachusetts General Hospital;   Thompson, Boyd Taylor, M.D., Massachusetts General Hospital;   Bonventre, Joseph V., M.D., Brigham Women Hospital;   Shann, Kenneth G., Massachusetts General Hospital;   Zapol, Warren M., M.D.;   Marrazzo, Francesco, M.D., Massachusetts General Hospital;   Spina, Stefano, M.D., Massachusetts General Hospital;   Zadek, Francesco, M.D., Massachusetts General Hospital;   Rezoagli, Emanuele, M.D., Massachusetts General Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Liver Damage and Cardiometabolic Disorders in NAFLD

Conditions:   NAFLD;   Liver Fibroses;   Cardiovascular Diseases;   Cardiovascular Risk Factor
Intervention:  
Sponsor:   University of Roma La Sapienza
Recruiting

In the Management of Coronary Artery Disease, Does Routine Pressure Wire Assessment at the Time of Coronary Angiography Affect Management Strategy, Hospital Costs and Outcomes?

Conditions:   Chest Pain;   Stable Angina;   Acute Coronary Syndrome;   Non ST Segment Elevation Acute Coronary Syndrome
Intervention:   Device: Routine Measurement of FFR
Sponsors:   University Hospital Southampton NHS Foundation Trust;   Liverpool Heart and Chest Hospital NHS Foundation Trust
Active, not recruiting

Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics

Conditions:   Osteomyelitis;   Diabetes;   Amputation
Interventions:   Drug: Rifampin;   Drug: Riboflavin Placebo
Sponsor:   VA Office of Research and Development
Recruiting

EVOlocumab for Early Reduction of LDL-cholesterol Levels in Patients With Acute Coronary Syndromes (EVOPACS)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Evolocumab 140 mg/mL;   Drug: Placebo
Sponsors:   University Hospital Inselspital, Berne;   Amgen;   University of Bern
Completed

Post-Acute Physician Home Visit Program

Condition:   A Patient Discharged From an Acute-care Hospital Who Had an Acute Illness
Intervention:   Other: Home visit
Sponsor:   Brigham and Women's Hospital
Completed