Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Feasibility of Using Prism Adaptation to Treat Spatial Neglect and Motor Function in Stroke

Condition:   Stroke
Intervention:   Behavioral: Prism Adaptation
Sponsor:   Kessler Foundation
Recruiting - verified April 2015

Canadian Pradaxa Acute Stroke Safety Study

Conditions:   Ischemic Attack, Transient;   Stroke
Intervention:   Drug: Dabigatran
Sponsors:   University of Alberta;   Boehringer Ingelheim
Recruiting - verified April 2015

Feasibility Study of Deep Brain Recordings for Learning and Memory

Condition:   Movement Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified March 2015

Brain Connectivity Supporting Language Recovery in Aphasia

Conditions:   Aphasia;   Stroke;   Speech Disorders;   Communications Disorders
Intervention:  
Sponsors:   Medical University of South Carolina;   National Institute on Deafness and Other Communication Disorders (NIDCD);   University of South Carolina
Recruiting - verified April 2015

Study Apixaban to Vitamin K Antagonist for the Prevention of Stroke or Systemic Embolism and Bleeding in Patients With Non-valvular Atrial Fibrillation and Acute Coronary Syndrome/Percutaneous Coronary Intervention

Condition:   Acute Coronary Syndromes
Interventions:   Drug: Apixaban;   Drug: vitamin K antagonist;   Drug: Acetylsalicylic acid;   Other: Acetylsalicylic acid placebo
Sponsors:   Bristol-Myers Squibb;   Pfizer;   Duke Clinical Research Institute
Not yet recruiting - verified April 2015

To Determine the Therapeutic Effect of the Music Glove and Conventional Hand Exercises to Subacute Stroke Patients

Condition:   Cerebrovascular Accident
Interventions:   Device: Music Glove;   Other: Conventional Hand Exercise Program
Sponsor:   University of California, Irvine
Recruiting - verified April 2015

Post-Market Clinical Follow-Up Study to Confirm Clinical Performance and Safety of the Codman Enterprise® 2 Vascular Reconstruction Device in the Endovascular Treatment of Intracranial Aneurysms

Condition:   Intracranial Aneurysm
Intervention:   Device: Enterprise 2 Vascular Reconstruction Device
Sponsor:   Codman & Shurtleff
Not yet recruiting - verified April 2015

Dynamic Contrast-enhanced Ultrasound Imaging for Cerebral Perfusion Measurement in Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke
Intervention:   Other: Ultrasound perfusion imaging
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified April 2015

Researches of Retinal Artery Lesions and Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   Capital Medical University
Active, not recruiting - verified April 2015

Muscle Ultrasound Measures as Biomarkers of Upper Motor Neuron Function

Condition:   Muscle Spasticity
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified March 2015

REperfusion With Cooling in CerebraL Acute IscheMia II

Conditions:   Ischemic Stroke;   Hypothermia
Interventions:   Procedure: Normothermia;   Procedure: Mild hypothermia;   Device: Trevo Pro Retriever (Stryker Corp.);   Device: Zoll Thermogard XP technology with the Quattro catheter
Sponsors:   WellStar Health System;   Zoll Medical Corporation
Not yet recruiting - verified April 2015

Vascular Ultrasound Screening in Patients With Ischemic Cerebrovascular Disease: a Multi-center Registry Study

Condition:   Stroke
Intervention:  
Sponsors:   Xuanwu Hospital, Beijing;   The First Affiliated Hospital of Shanxi Medical University;   Liaocheng Brains Hospital;   Tianjin Huanhu Hospital;   Baotou City Central Hospital;   First Hospital of Jilin University;   First Affiliated Hospital of Harbin Medical University;   First Hospital of China Medical University;   LanZhou University;   First Affiliated Hospital of Xinjiang Medical University;   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School;   The First Affiliated Hospital of Soochow University;   Anhui Provincial Hospital;   Guangdong Provincial Hospital of Traditional Chinese Medicine;   Zhuhai  People's Hospital;   Fujian Provincial Hospital;   Mianyang Central Hospital;   The Second Affiliated Hospital of Kunming Medical University;   Brains Hospital of Hunan Province;   Henan Provincial Hospital;   Luoyang Central Hospital Affiliated to Zhengzhou University;   National Health and Family Planning Commission Stroke Prevention Engineering Committee
Not yet recruiting - verified March 2015

Preconditioning With Limb Ischemia for Subarachnoid Hemorrhage

Condition:   Ischemic Preconditioning
Intervention:   Other: ischemic conditioning group
Sponsor:   University of Miami
Recruiting - verified April 2015

Safety and Efficacy of Low-Dose Ticagrelor in Chinese Patients With NSTE-ACS

Condition:   Non ST Segment Elevation Acute Coronary Syndrome
Interventions:   Drug: low-dose ticagrelor;   Drug: conventional-dose ticagrelor;   Drug: Clopidogrel
Sponsor:   First Affiliated Hospital of Harbin Medical University
Recruiting - verified December 2014

Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: Tenecteplase;   Drug: Tissue Plasminogen Activator
Sponsors:   Neuroscience Trials Australia;   The Florey Institute of Neuroscience and Mental Health
Recruiting - verified April 2015

Fluid Responsiveness in the Postoperative Patient: a Prospective Study

Condition:   Actual Impaired Fluid Volume
Intervention:   Drug: Fluid challenge (250 ml Lactated Ringer's solution)
Sponsor:   McGill University Health Center
Not yet recruiting - verified April 2015

Dry Needling for Spasticity in Stroke

Condition:   Stroke
Interventions:   Other: Dry needling;   Other: Physical Therapy;   Device: stainless steel needles (0.3mm x 50mm)
Sponsor:   Universidad Rey Juan Carlos
Completed - verified April 2015

Immediate Versus Delayed Invasive Intervention for Non-STEMI Patients

Condition:   Myocardial Infarction
Interventions:   Procedure: Immediate invasive intervention;   Procedure: Delayed invasive intervention;   Device: Coronary artery stenting
Sponsor:   Clinical Centre of Serbia
Active, not recruiting - verified April 2015

Robotic Therapy and Transcranial Direct Current Stimulation in Patients With Stroke

Condition:   Stroke
Interventions:   Device: Robotic Therapy;   Device: Active tDCS;   Device: Sham tDCS;   Other: Physical Therapy;   Other: Occupational Therapy
Sponsors:   University of Sao Paulo General Hospital;   Conselho Nacional de Desenvolvimento Científico e Tecnológico
Not yet recruiting - verified December 2014

CardiOvascular Risk and idEntificAtion of Potensial High-risk Population in Acute Myocardial Infarction

Conditions:   Long-term Major Cardiovascular Events;   Myocardial Infarction;   Percutaneous Coronary Intervention
Interventions:   Device: Percutaneous coronary intervention;   Device: Percutaneous coronary intervention
Sponsors:   Kiyuk Chang;   The Catholic University of Korea;   Chonnam National University
Completed - verified April 2015

Altering Activation Patterns Post-stroke

Conditions:   Stroke;   Muscle Spasticity;   Hemiparesis
Interventions:   Drug: Cyproheptadine;   Drug: Placebo for Cyproheptadine;   Other: Active Movement Practice (AMP);   Other: Passive Cyclical Stretching
Sponsors:   Rehabilitation Institute of Chicago;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Not yet recruiting - verified April 2015

Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects

Condition:   Familial Frontotemporal Dementia
Intervention:  
Sponsors:   Mayo Clinic;   National Institute on Aging (NIA);   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified April 2015

The Outcomes of Seamless ADL Training Between Occupational Therapist and Nurse in Stroke Patients

Condition:   Stroke
Interventions:   Procedure: Seamless ADL training;   Procedure: Conventional ADL training
Sponsor:   Mahidol University
Recruiting - verified April 2015

ReAl-life Multicentre Survey Evaluating Stroke Prevention Strategies (RAMSES)

Conditions:   Thrombotic Stroke;   Atrial Fibrillation and Flutter
Intervention:  
Sponsor:   Muğla Sıtkı Koçman University
Recruiting - verified April 2015

Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism (RESCUE)-Japan RCT

Condition:   Ischemic Stroke
Interventions:   Procedure: Rescue endovascular therapy;   Procedure: No endovascular therapy
Sponsor:   Shinichi Yoshimura
Recruiting - verified April 2015

Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism (RESCUE)-Japan Registry 2

Condition:   Ischemic Stroke
Intervention:   Procedure: endovascular treatment
Sponsor:   Hyogo College of Medicine
Recruiting - verified April 2015

Weight Loss Referral for Healthier Survivorship in Obese Stage I-II Endometrial Cancer Survivors or Atypical Hyperplasia

Conditions:   Complex Endometrial Hyperplasia With Atypia;   Stage IA Uterine Corpus Cancer;   Stage IB Uterine Corpus Cancer;   Stage II Uterine Corpus Cancer
Interventions:   Behavioral: Weight Loss Specialist;   Other: Quality-of-Life Assessment;   Other: Medical Chart Review
Sponsors:   Case Comprehensive Cancer Center;   National Cancer Institute (NCI)
Recruiting - verified April 2015

RuSsian RegisTry of Acute CoronaRy SyndromE TreAtMent and Approach in Dual Antiplatelet Therapy

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   AstraZeneca
Not yet recruiting - verified April 2015

Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System

Condition:   Mitral Valve Regurgitation
Intervention:   Device: Mitral valve replacement
Sponsor:   Neovasc Inc.
Recruiting - verified March 2015

The General Use of Robots in Stroke Recovery: the Anklebot

Condition:   Stroke
Intervention:   Device: MIT Anklebot
Sponsor:   North Shore Long Island Jewish Health System
Recruiting - verified April 2015

Program for the Identification of "Actionable" Atrial Fibrillation in the Family Practice Setting

Condition:   Atrial Fibrillation
Interventions:   Other: 30 Second Pulse Check;   Device: Watch BP Home A;   Device: HeartCheck Hand-held ECG device
Sponsors:   Population Health Research Institute;   Canadian Institutes of Health Research  (CIHR)
Recruiting - verified April 2015

Pilot Study to Examine the Use of Rivaroxaban After Angioplasty for Critical Limb Ischemia

Condition:   Critical Limb Ischemia
Interventions:   Drug: rivaroxaban plus aspirin;   Drug: clopidogrel plus aspirin
Sponsors:   Ottawa Hospital Research Institute;   The Ottawa Hospital
Recruiting - verified April 2015

Evaluating Anodal tDCS Preceding Aphasia Therapy

Conditions:   Stroke;   Aphasia
Intervention:   Device: transcranial direct current stimulation
Sponsor:   North Shore Long Island Jewish Health System
Recruiting - verified April 2015

Occult Paroxysmal Atrial Fibrillation in Non-Cryptogenic Ischemic Stroke

Condition:   Ischemic Stroke
Intervention:   Device: Reveal LINQ Insertable Cardiac Monitor
Sponsor:   North Shore Long Island Jewish Health System
Recruiting - verified April 2015

Brain fMRT In Takotsubo Cardiomyopathy

Condition:   Takotsubo Cardiomyopathy
Intervention:  
Sponsor:   Wolfgang Dichtl
Recruiting - verified April 2015

Monitoring Everyday Life Motor Activity in Children

Condition:   Neurologic Disorders
Intervention:  
Sponsors:   Rob Labruyere;   Children's Research Center, Zurich
Recruiting - verified April 2015

Combined Antagonistic Muscle Magnetic Stimulation and Selective Periferal Neurotomy to Improve Results on Spasticity

Condition:   STROKE
Interventions:   Procedure: - Postoperative Antagonistic Peripheral Magnetic Stimulation;   Device: Selected Peripheral Magnetic Stimulation;   Other: Kinesics
Sponsor:   Juan Carlos M. Andreani
Enrolling by invitation - verified April 2015

Canadian Alliance for Healthy Hearts and Minds

Condition:   Cardiovascular Diseases
Intervention:   Other: MRI
Sponsor:   Montreal Heart Institute
Recruiting - verified April 2015

Effects rTMS Combined With Fluoxetine on Motor Recovery in Stroke Patients

Conditions:   Stroke;   Motor Function
Interventions:   Device: Active Repetitive Transcranial Magnetic Stimulation (rTMS);   Drug: Fluoxetine;   Device: Sham repetitive transcranial magnetic stimulation (rTMS);   Drug: Placebo Fluoxetine
Sponsor:   Spaulding Rehabilitation Hospital
Recruiting - verified April 2015

Cardiovascular Patient Outcomes and Research Team Primary PCI Registry

Condition:   ST Elevation Myocardial Infarction
Intervention:  
Sponsor:   Johns Hopkins University
Recruiting - verified April 2015

COAST: Coiling of Aneurysms Smaller Than 5mm With Hypersoft®

Condition:   Small Intracranial Aneurysms
Intervention:   Device: HyperSoft® 3D
Sponsor:   Medical University of South Carolina
Recruiting - verified April 2015

Active Surveillance Research Program for the Assessment of the Safety and the Effectiveness of Linagliptin

Condition:   Diabetes Mellitus, Type 2
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

Efficacy of Levetiracetam in Oromandibular and Cranial Dystonia

Conditions:   Oromandibular Dystonia;   Cranial Dystonia
Intervention:   Drug: Levetiracetam
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified June 2014

Intramuscular Oxytocics: A Comparison Study of Intramuscular Carbetocin, Syntocinon and Syntometrine for the Third Stage of Labour Following Vaginal Birth

Condition:   Post Partum Haemorrhage
Interventions:   Drug: Carbetocin;   Drug: Syntocinon;   Drug: Syntometrine
Sponsors:   North Bristol NHS Trust;   Ferring Pharmaceuticals;   University of Bristol;   University of the West of England;   Royal United Hospital Bath NHS Trust;   Gloucester Hospitals NHS Trust;   University Hospitals Bristol NHS Foundation Trust
Recruiting - verified August 2014

Nondependent Lung Ventilation and Fluid Responsiveness

Conditions:   Lung Disease;   Undergoing Thoracosocpic Surgery
Interventions:   Procedure: High Frequency Positive Pressure Ventilation;   Procedure: Continuous Positive Airway Pressure
Sponsor:   Dammam University
Not yet recruiting - verified April 2015

Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage (The PATCH Study)

Conditions:   Wounds and Injuries;   Acute Coagulopathy
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsors:   National Trauma Research Institute;   National Health and Medical Research Council, Australia
Recruiting - verified April 2015

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease, on Dialysis

Condition:   Anemia
Interventions:   Drug: Roxadustat;   Drug: Epoetin alfa
Sponsors:   AstraZeneca;   FibroGen
Recruiting - verified April 2015

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease (CKD), Not on Dialysis.

Condition:   Anemia
Interventions:   Drug: Roxadustat;   Drug: Placebo
Sponsors:   AstraZeneca;   FibroGen
Recruiting - verified April 2015

Efficacy and Security of an Endovascular Treatment as First Choice Procedure Compared With a Standard Intravenous Thrombolytic Therapy Treatment for Patients With Acute Ischemic Stroke Within 4.5 Hours After Onset

Condition:   Acute Ischaemic Stroke
Interventions:   Procedure: EVT (endovascular treatment );   Procedure: IVT (intravenous thrombolytic therapy)
Sponsor:   Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Active, not recruiting - verified June 2014

Post-Stroke Disease Management - Stroke Card

Conditions:   Stroke;   Ischemic Attack, Transient;   Secondary Prevention;   Disease Management;   Cost-Benefit Analysis
Interventions:   Behavioral: Active Comparator: Extended Standard Care (Stroke Card);   Behavioral: Active Comparator: Standard Care
Sponsors:   Medical University Innsbruck;   Center of Excellence in Medicine and IT (CEMIT);   Tiroler Landeskrankenanstalten GmbH (TILAK);   Tiroler Gebietskrankenkasse (TGKK);   Tiroler Gesundheitsfonds (TGF);   Private Universität für Gesundheitswissenschaften, Medizinische Informatik und Technik (UMIT)
Recruiting - verified April 2015

Efficacy of Isradipine in Early Parkinson Disease

Condition:   Parkinson Disease
Interventions:   Drug: Isradipine;   Drug: Placebo (for Isradipine)
Sponsors:   University of Rochester;   National Institute of Neurological Disorders and Stroke (NINDS);   Michael J. Fox Foundation for Parkinson's Research
Recruiting - verified April 2015

Early Post-marketing Study of Eliquis (Apixaban)

Condition:   Non-valvular Atrial Fibrillation (NVAF)
Intervention:   Drug: Apixaban
Sponsor:   Bristol-Myers Squibb
Active, not recruiting - verified February 2015

Clinical Autonomic Disorders: A Training Protocol

Conditions:   Chronic Fatigue Syndrome;   Pseudopheochromocytoma;   Healthy Volunteers;   Neurocardiogenic Syncope;   Postural Tachycardia Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2015

Ascertainment of EMR-based Clinical Covariates Among Patients Receiving Oral and Non-insulin Injected Hypoglycemic Therapy

Condition:   Diabetes Mellitus, Type 2
Intervention:  
Sponsor:   Boehringer Ingelheim
Completed - verified April 2015

A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients

Conditions:   Heart Failure;   Respiratory Insufficiency;   Stroke Acute;   Infectious Diseases;   Rheumatic Diseases
Interventions:   Drug: Rivaroxaban, 10 mg;   Drug: Rivaroxaban, 7.5 mg;   Drug: Placebo
Sponsor:   Janssen Research & Development, LLC
Recruiting - verified April 2015

Combined Bronchodilators in Chronic Obstructive Pulmonary Disease and the Risk of Adverse Cardio-pulmonary Events

Condition:   Pulmonary Disease, Chronic Obstructive
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified April 2015

Niche Trial: Navigated Inhibitory rTMS to Contralesional Hemisphere Trial

Condition:   Stroke
Interventions:   Device: NBS-guided rTMS;   Device: Sham rTMS
Sponsor:   Nexstim Ltd
Recruiting - verified April 2015

Acute Effects After Stretching Respiratory Muscles on Ventilatory Pattern and Volume Distribution of Chest Wall

Condition:   Stroke
Interventions:   Other: Respiratory Muscles Stretching;   Other: Control Group
Sponsors:   Universidade Federal de Pernambuco;   Conselho Nacional de Desenvolvimento Científico e Tecnológico
Completed - verified March 2014

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy;   Device: Carotid stenting
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Sequential Expansion of Comparative Effectiveness of Anticoagulants

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

Triple vs. Dual Therapy

Conditions:   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Ticagrelor + Apixaban + ASA;   Drug: Ticagrelor + Apixaban
Sponsor:   Medical University of Vienna
Completed - verified April 2015

Edoxaban vs. Warfarin in Subjects Undergoing Cardioversion of Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Drug: edoxaban;   Drug: Enoxaparin;   Drug: Warfarin
Sponsors:   Daiichi Sankyo Inc.;   Covance;   Quintiles
Recruiting - verified April 2015

Blood-brain Barrier Quantification in Cerebral Small Vessel Disease

Conditions:   Blood-Brain Barrier Permeability;   Cerebral Small Vessel Disease;   Cerebral Hemorrhage;   Cortical Stroke
Intervention:   Procedure: Dynamic contrast enhanced Brain MRI
Sponsor:   Maastricht University Medical Center
Recruiting - verified April 2015

Effects of Novel Game Rehabilitation System on Upper Extremity Function of Patients With Stroke

Condition:   Stroke
Interventions:   Device: E-glove system;   Procedure: Conventional occupational therapy
Sponsors:   National Rehabilitation Center, Seoul, Korea;   Ministry of Trade, Industry & Energy, Republic of Korea;   National IT Industry Promotion Agency, Republic of Korea
Active, not recruiting - verified April 2015

HIP Fracture Accelerated Surgical TreaTment And Care tracK (HIP ATTACK) Trial

Condition:   Hip Fractures
Intervention:   Other: Accelerated medical clearance and surgery
Sponsors:   Population Health Research Institute;   McMaster University
Recruiting - verified April 2015

Verification of the Safety of Early Discharge in Patients After Acute ST-segment Myocardial Infarction

Conditions:   Coronary Artery Disease;   Acute Myocardial Infarction With ST-segment Elevation;   Primary Percutaneous Coronary Intervention;   Early Discharge
Interventions:   Other: Early discharge;   Other: Standard discharge
Sponsor:   Kamil Novobílský
Recruiting - verified April 2015

Dosage and Predictors of Naming Treatment Response in Aphasia

Conditions:   Aphasia;   Stroke
Intervention:   Behavioral: Naming therapy
Sponsor:   Department of Veterans Affairs
Recruiting - verified April 2015

Cardiovascular Outcomes Following Treatment With Ertugliflozin in Participants With Type 2 Diabetes Mellitus and Established Vascular Disease (MK-8835-004)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Ertugliflozin;   Drug: Placebo
Sponsors:   Merck Sharp & Dohme Corp.;   Pfizer
Recruiting - verified April 2015

Single Session Percutaneous Mechanical Thrombectomy for the Treatment of Ilio-femoral Deep Vein Thrombosis: A Preliminary Evaluation

Conditions:   Deep Vein Thrombosis;   Venous Thromboembolism
Intervention:   Device: Thrombectomy
Sponsor:   Ottawa Hospital Research Institute
Terminated - verified April 2015

The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified April 2015

A Clinical Trial to Evaluate the HeartWare® Ventricular Assist System (ENDURANCE SUPPLEMENTAL TRIAL)

Condition:   Chronic Heart Failure
Interventions:   Device: HeartWare® VAS;   Device: Control LVAD
Sponsor:   HeartWare, Inc.
Recruiting - verified April 2015

Remediation of Spatial Neglect Trial

Conditions:   Stroke;   Acquired Brain Injury;   Hemispatial Neglect
Interventions:   Other: Computerized Plasticity-based Software;   Other: Commercially available software
Sponsor:   Posit Science Corporation
Recruiting - verified April 2015

A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Events

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: insulin degludec;   Drug: insulin glargine
Sponsor:   Novo Nordisk A/S
Active, not recruiting - verified April 2015

Robotic-assisted Gait Training Combined With Transcranial Direct Current Stimulation to Maximize Gait Recovery After Stroke

Condition:   Stroke
Interventions:   Device: tDCS;   Device: Robotic-assisted gait training
Sponsor:   Seoul National University Hospital
Recruiting - verified April 2015

GLORIA-AF Registry Program (Phase II/III)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

Neuroplastic Change in Myelin of the Brain

Condition:   Stroke
Intervention:   Behavioral: TRAIT Task
Sponsors:   University of British Columbia;   Canadian Institutes of Health Research  (CIHR)
Recruiting - verified April 2015

Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation

Condition:   Amyotrophic Lateral Sclerosis
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Aging (NIA)
Recruiting - verified March 2015

Xenon as an Adjuvant to Propofol Anaesthesia in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery.

Conditions:   Coronary Artery Disease;   Anesthesia
Interventions:   Drug: Xenon and propofol;   Drug: propofol
Sponsor:   Universitaire Ziekenhuizen Leuven
Completed - verified April 2015

PWV for Cardiovascular Complication After Cardiac Surgery

Condition:   C.Surgical Procedure; Cardiac
Intervention:  
Sponsors:   Seoul National University Hospital;   SMG-SNU Boramae Medical Center
Completed - verified April 2015

HCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Intervention:   Other: None - this is an observational study
Sponsors:   University of Virginia;   National Heart, Lung, and Blood Institute (NHLBI);   Oxford University Hospitals NHS Trust
Recruiting - verified April 2015

The Singapore Tele-technology Aided Rehabilitation in Stroke (STARS) Study

Condition:   Stroke
Intervention:   Other: Tele-rehabilitation
Sponsors:   National University, Singapore;   Singapore Millennium Foundation;   Singapore General Hospital;   Ang Mo Kio Thye Hua Kwan Hospital
Recruiting - verified April 2015

Non-interventional Local Study on Prescription Behavior of Anticoagulation Therapy in Secondary Stroke Prevention in Atrial Fibrillation Patients

Conditions:   Stroke,;   Embolism
Intervention:   Other: Rivaroxaban ( Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified April 2015

A Study of Movement Disorders Using the QMAT At-Home Testing Device

Conditions:   Movement Disorders;   Parkinson's Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified April 2015

Electrical Impedance Myography: Exploratory Studies in Healthy People and People With Neuromuscular Disorders

Conditions:   Neuromuscular Disease;   Motor Neuron Disease;   Inherited Neuromuscular Conditions;   Inherited Neuropathies
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2015

A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure

Conditions:   Heart Failure;   Coronary Artery Disease
Interventions:   Drug: Rivaroxaban;   Drug: Placebo;   Other: Standard of care for heart failure and coronary artery disease
Sponsors:   Janssen Research & Development, LLC;   Bayer
Recruiting - verified April 2015

Improving Patient Access to Stroke Therapy Study

Conditions:   Ischemic Stroke;   Transient Ischemic Attack
Interventions:   Drug: Activase;   Device: Endovascular therapy
Sponsor:   Medical College of Wisconsin
Recruiting - verified April 2015

Vein of Marshall Ethanol Infusion for Persistent Atrial Fibrillation FIBRILLATION

Conditions:   Ventricular Tachycardia;   Atrial Fibrillation
Interventions:   Drug: Ethanol;   Procedure: Ablation
Sponsors:   The Methodist Hospital System;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 2015

Cerebrospinal Fluid Collection and Repository Storage

Condition:   Neurological Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2015

Effects of tDCS Combined With mCIMT or Mental Practice in Poststroke Patients

Condition:   Stroke
Intervention:   Other: tDCS
Sponsor:   Universidade Federal de Pernambuco
Completed - verified May 2014

Nutrition Blood Outcomes Following Tocotrienol N2B

Condition:   Stroke
Interventions:   Dietary Supplement: Tocotrienol Capsules;   Other: Placebo Vehicle
Sponsors:   Ohio State University;   Malaysian Palm Oil Board
Recruiting - verified April 2015

A Very Early Rehabilitation Trial

Condition:   Stroke
Interventions:   Other: Standard Care + VEM;   Other: Standard care
Sponsors:   Neuroscience Trials Australia;   Singhealth Foundation;   Chest, Heart and Stroke Association Scotland;   Northern Ireland Chest Heart and Stroke;   The Stroke Association - UK;   National Institute for Health Research, United Kingdom
Completed - verified April 2015

Exercise Education for Adults With Seizure Disorders

Conditions:   Seizures;   Epilepsy
Intervention:   Other: Patient Education
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2015

Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes?

Conditions:   Congestive Heart Failure;   Infections;   Sepsis;   Acute Renal Failure;   Stroke
Intervention:   Other: Script and CPR/Mechanical ventilation video.
Sponsor:   Jewish Hospital, Cincinnati, Ohio
Completed - verified April 2015

POSITIVE Stroke Clinical Trial

Condition:   Ischemic Stroke
Intervention:   Device: Endovascular Mechanical Thrombectomy
Sponsors:   Medical University of South Carolina;   Vanderbilt University
Recruiting - verified April 2013

PREdicting Atrial Fibrillation or Flutter

Conditions:   Atrial Fibrillation;   Atrial Flutter
Intervention:  
Sponsor:   Keesler Air Force Base Medical Center
Active, not recruiting - verified April 2015

Anticoagulant Utilization Pattern

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

Study of Procoagulation Markers in Stroke Patients

Conditions:   Stroke;   Hyperglycemia;   Procoagulation Markers
Intervention:   Other: Glycemic Control
Sponsors:   Temple University;   National Institute of Neurological Disorders and Stroke (NINDS);   Neurological Emergencies Treatment Trials Network (NETT);   University of Virginia;   University of Michigan;   Medical University of South Carolina;   Georgia Regents University
Recruiting - verified April 2015

A Prospective Multicenter Post Approval Study to Evaluate the Long-term Safety and Efficacy of the Resolute Integrity in the Japanese All-comers Patients With Coronary Artery Disease (PROPEL)

Conditions:   Coronary Artery Disease;   Drug-eluting Stent
Intervention:  
Sponsors:   Associations for Establishment of Evidence in Interventions;   Medtronic Vascular
Active, not recruiting - verified April 2015

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention & Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute
Recruiting - verified April 2015

Not Invasive Monitoring of Pleural Drainage

Condition:   Pleural Effusion
Intervention:   Device: Body Bioimpedance Sensor
Sponsor:   RWTH Aachen University
Completed - verified April 2015

COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure.

Conditions:   Modified Release Oral Formulation;   Left Ventricular Systolic Dysfunction;   Chronic Heart Failure;   History of Chronic Heart Failure;   Left Ventricular Ejection Fraction;   Pharmacokinetics;   Echocardiogram
Interventions:   Drug: Omecamtiv mecarbil;   Drug: Omecamtiv mecarbil;   Drug: Placebo;   Drug: Omecamtiv Mecarbil;   Drug: Omecamtiv Mecarbil
Sponsors:   Amgen;   Cytokinetics
Active, not recruiting - verified April 2015

Effects of Transcranial Magnetic Stimulation on Object Recognition

Conditions:   Repetitive TMS (rTMS);   Sham rTMS;   Bilateral rTMS;   Unilateral rTMS
Interventions:   Procedure: Sham rTMS;   Procedure: Bilateral rTMS at same frequency and in phase;   Procedure: Bilateral rTMS at different frequencies;   Procedure: Bilateral rTMSat same frequency and out of phase;   Procedure: rTMS over TP8;   Procedure: rTMS over TP7
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2015

TARGET Intracranial Aneurysm Coiling Registry

Condition:   Intracranial Aneurysms
Intervention:   Device: Target 360°, 2D Coils, Nano Coils
Sponsors:   Osama Zaidat, MD, MSc;   Stryker Neurovascular
Recruiting - verified April 2015

LARGE Aneurysm Randomized Trial: Flow Diversion Versus Traditional Endovascular Coiling Therapy

Condition:   Intracranial Aneurysm
Interventions:   Procedure: Flow Diversion;   Procedure: Coiling
Sponsor:   Medical University of South Carolina
Recruiting - verified April 2015

Robots Paired With tDCS in Stroke Recovery

Condition:   Stroke
Interventions:   Device: Transcranial Direct Current Stimulation (tDCS);   Device: Placebo sham
Sponsor:   North Shore Long Island Jewish Health System
Recruiting - verified April 2015

The Role of HMGB-1 in Chronic Stroke

Conditions:   Cerebrovascular Accident;   Cerebral Stroke;   Stroke, Acute
Intervention:  
Sponsor:   North Shore Long Island Jewish Health System
Recruiting - verified April 2015

STOP-AUST: The Spot Sign and Tranexamic Acid On Preventing ICH Growth - AUStralasia Trial

Conditions:   Intracerebral Haemorrhage;   Stroke
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsor:   Neuroscience Trials Australia
Recruiting - verified September 2014

Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics

Condition:   Hypertension
Intervention:   Other: Sevoflurane/oxygen/air/nitrous oxide
Sponsors:   Lawson Health Research Institute;   University of Western Ontario, Canada
Recruiting - verified April 2015

Contralaterally Controlled FES of Arm & Hand for Subacute Stroke Rehabilitation

Conditions:   Stroke;   Hemiparesis;   Hemiplegia
Intervention:   Device: Electrical stimulator
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified April 2015

Mechanisms of Neuromuscular Fatigue Post Stroke

Condition:   Stroke
Interventions:   Drug: duloxetine;   Drug: Cyproheptadine;   Drug: Placebo
Sponsor:   Medical College of Wisconsin
Active, not recruiting - verified April 2015

Balance Rehabilitation With Sensory Recalibration After Stroke

Condition:   Left-sided Hemiplegia Affecting Dominant Side as Late Effect of Cerebrovascular Accident
Interventions:   Other: Cervical vibration;   Other: Prism adaptation;   Other: Conventional rehabilitation
Sponsor:   Rennes University Hospital
Recruiting - verified April 2015

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

Comparison of Platelet Rich Plasma and Alternative Therapies for the Treatment of Tennis Elbow (Lateral Epicondylitis)

Condition:   Lateral Epicondylitis (Tennis Elbow)
Interventions:   Other: Platelet Rich Plasma (PRP) Injection;   Other: Whole Blood Injection;   Other: Dry Needle Fenestration;   Other: Sham Injection
Sponsors:   McMaster University;   Arthrex, Inc.;   The Physicians' Services Incorporated Foundation;   Radiological Society of North America
Recruiting - verified April 2015

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab SAR236553 (REGN727)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Other: placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified April 2015

Adverse Effects of Systemic Hypoglycemia Exposure on Endothelial Function in Humans

Condition:   Type 2 Diabetes
Intervention:   Other: Glycemic clamping
Sponsor:   Medical College of Wisconsin
Terminated - verified April 2015

Self-directed Titrated Transdermal Nicotine Patch Versus Standard Treatment for Smoking Cessation

Condition:   Smoking Cessation
Interventions:   Drug: NicoDerm Patch;   Drug: Nicorette Inhaler
Sponsors:   Ottawa Heart Institute Research Corporation;   Heart and Stroke Foundation of Ontario
Completed - verified April 2015

BOTOX® Treatment in Pediatric Upper Limb Spasticity

Conditions:   Pediatrics;   Muscle Spasticity;   Cerebral Palsy;   Stroke
Interventions:   Biological: botulinum toxin Type A;   Biological: botulinum toxin Type A;   Drug: Normal Saline (Placebo)
Sponsor:   Allergan
Recruiting - verified April 2015

BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity

Conditions:   Pediatrics;   Muscle Spasticity;   Cerebral Palsy;   Stroke
Intervention:   Biological: botulinum toxin Type A
Sponsor:   Allergan
Recruiting - verified April 2015

EXTEND (International): Extending the Time for Thrombolysis in Emergency Neurological Deficits (International)

Condition:   Stroke
Interventions:   Drug: Tissue Plasminogen Activator (Alteplase);   Drug: Placebo
Sponsors:   Neuroscience Trials Australia;   China Medical University Hospital
Recruiting - verified September 2014

Music Therapy/Physical Therapy Intervention to Enhance Well-being and Functional Recovery Post-stroke

Condition:   Stroke With Hemiparesis
Intervention:   Other: Music & Physical Therapy
Sponsors:   New York University School of Medicine;   New York University
Active, not recruiting - verified April 2015

Use of Repetitive Facilitative Exercise Program in Established Stroke

Condition:   Stroke
Intervention:   Other: Occupational therapy- Repetitive Facilitative Exercise
Sponsor:   Mayo Clinic
Recruiting - verified April 2015

NUTRITION: Natural Tocotrienol Against Ischemic Stroke Event

Conditions:   Ischemic Stroke;   Transient Ischemic Attack (TIA)
Interventions:   Other: Vitamin E tocotrienol (TCT) capsules ; Low dose Aspirin;   Other: Placebo vehicle control
Sponsors:   Chandan K Sen;   Government of Malaysia
Recruiting - verified April 2015

Structurally Reorganizing Motor Cortex in Stroke Patients Through Hebbian-type Stimulation

Condition:   Stroke
Interventions:   Device: Repetitive Transcranial Magnetic Stimulation (rTMS);   Device: Sham stimulation
Sponsors:   Cathrin Buetefisch;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified April 2015

Role of Ipsilateral Motor Cortex in Executing Movements With Increasing Demand on Precision

Condition:   Stroke
Intervention:  
Sponsors:   Cathrin Buetefisch;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular Septum

Conditions:   Left Ventricular Dysfunction;   Cardiac Conduction Defect;   Heart Failure;   Sick Sinus Syndrome
Intervention:   Device: Left ventricular septum pacing lead
Sponsors:   Maastricht University Medical Center;   Medtronic Bakken Research Center
Recruiting - verified April 2015

Botulinum Toxin for Pelvic Pain in Women With Endometriosis

Conditions:   Endometriosis;   Botulinum Toxin A;   Chronic Pelvic Pain;   Pelvic Muscle Spasms;   Quality of Life
Intervention:   Drug: Botuninum toxin A
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified May 2014

Efficiency Study Evaluating the Use of the PVAC Catheter Technology for Performing Ablation in Patients With Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Device: Radiofrequency Ablation Procedure;   Device: Radiofrequency Ablation Procedure
Sponsors:   Newmarket Electrophysiology Research Group Inc;   Medtronic
Recruiting - verified April 2015

Cyclosporine and Prognosis in Acute Myocardial Infarction (MI) Patients

Condition:   ST Elevation Acute Myocardial Infarction
Interventions:   Drug: Injection of Cyclosporin;   Drug: Placebo;   Procedure: Echocardiography
Sponsor:   Hospices Civils de Lyon
Active, not recruiting - verified April 2015

Step Monitoring to Improve ARTERial Health

Conditions:   Type 2 Diabetes;   Hypertension
Interventions:   Behavioral: Step count prescription;   Behavioral: Usual care
Sponsors:   McGill University Health Center;   Canadian Institutes of Health Research  (CIHR)
Active, not recruiting - verified April 2015

GLORIA-AF Registry Program - Second and Third Phases

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

A Open-Label Study Of CP-690,550 As Long-Term Therapy (48 Weeks) In Subjects With Crohn's Disease

Condition:   Crohn's Disease
Interventions:   Drug: CP-690,550;   Drug: CP-690,550
Sponsor:   Pfizer
Recruiting - verified April 2015

Randomized, Open Label Trial of 6 Months Versus 12 Months DAPT After Drug-Eluting Stent in STEMI

Conditions:   Myocardial Infarction;   Cardiovascular Disease
Interventions:   Other: 6 months DAPT;   Other: 12 months DAPT
Sponsors:   Maasstad Hospital;   Medtronic
Recruiting - verified April 2015

Study of the Recovery of Muscle Function in the Arm/Hand After a Stroke

Conditions:   Stroke;   Hemiparesis
Interventions:   Other: Simultaneous Bimanual training;   Other: Conventional Occupational Therapy
Sponsors:   New York University School of Medicine;   Mount Sinai School of Medicine
Recruiting - verified April 2015

Study of Botulinum Toxin and Recovery of Hand Function After Stroke

Condition:   Stroke With Hemiparesis
Intervention:   Drug: Botulinum Toxin commonly known as BOTOX®
Sponsors:   New York University School of Medicine;   Allergan
Completed - verified April 2015

Hyper-CVAD and Ponatinib in Ph-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia (ALL)

Condition:   Leukemia
Interventions:   Drug: Cyclophosphamide;   Drug: Mesna;   Drug: Doxorubicin;   Drug: Vincristine;   Drug: Dexamethasone;   Drug: Ponatinib;   Drug: G-CSF  (Filgrastim);   Drug: Rituximab;   Drug: Methotrexate;   Drug: Cytarabine;   Drug: Solu-medrol ( Methyl Prednisolone);   Drug: Citrovorum (Leucovorin);   Drug: Prednisone;   Drug: Pegfilgrastim (Neulasta)
Sponsors:   M.D. Anderson Cancer Center;   Ariad Pharmaceuticals
Recruiting - verified April 2015

Bazedoxifene Post Approval Safety Study (PASS) in the European Union (EU)

Condition:   Osteoporosis, Postmenopausal
Interventions:   Drug: Bazedoxifene;   Drug: Bisphosphonate;   Drug: Raloxifene
Sponsor:   Pfizer
Active, not recruiting - verified April 2015

ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis

Conditions:   Tetraplegia;   Spinal Cord Injury;   Brachial Plexus Injury;   Muscular Dystrophy;   ALS;   Brainstem Stroke
Intervention:   Device: Implantation of ECoG sensors on the brain surface
Sponsor:   University of Pittsburgh
Completed - verified April 2015

The Application of Thermal Stimulation on Functional Recovery of Stroke Patients

Condition:   Stroke
Interventions:   Other: Noxious TS;   Other: Innocuous TS;   Other: High Frequency of Noxious TS;   Other: Low Frequency of Noxious TS;   Other: High Intensity of Noxious TS;   Other: Low Intensity of Noxious TS
Sponsors:   Kaohsiung Medical University Chung-Ho Memorial Hospital;   E-DA Hospital;   Kaohsiung Municipal Hsiaokang Hospital
Completed - verified April 2015

Reducing Cardiovascular Disease by Combining Smoking Cessation Pharmacotherapy and Behavioural Counseling

Conditions:   Smoking Cessation;   Psychiatric Illness
Interventions:   Drug: Champix;   Drug: Transdermal Nicoderm patch combined with gum or inhaler;   Drug: Transdermal Nicoderm patch
Sponsors:   Ottawa Heart Institute Research Corporation;   Heart and Stroke Foundation of Ontario
Completed - verified April 2015

Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia

Condition:   Cardiac Arrest
Interventions:   Drug: amiodarone;   Drug: Lidocaine;   Other: Normal saline
Sponsors:   University of Washington;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research  (CIHR);   Heart and Stroke Foundation of Canada;   American Heart Association;   Defence Research and Development Canada;   U.S. Army Medical Research and Materiel Command
Recruiting - verified April 2015

Interhemispheric Inhibitory Interactions

Condition:   Stroke
Intervention:   Other: continuous theta burst stimulation
Sponsor:   Canadian Institutes of Health Research  (CIHR)
Active, not recruiting - verified April 2015

Current Clinical Practice in the Management of Atrial Fibrillation in Greece: the MANAGE-AF Study

Condition:   Atrial Fibrillation
Intervention:  
Sponsors:   Hellenic Cardiovascular Research Society;   Bayer
Completed - verified April 2015

ShuntCheck Versus Radionuclide in Evaluating Shunt Function in Symptomatic NPH Patients

Condition:   Hydrocephalus
Intervention:   Device: ShuntCheck test
Sponsors:   NeuroDx Development;   Sinai Hospital of Baltimore;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

INcrease Of VAgal TonE in CHF

Conditions:   Left Ventricular Dysfunction;   Heart Failure
Interventions:   Device: CardioFit® System;   Other: Standard of Care
Sponsor:   BioControl Medical
Recruiting - verified April 2015

Evaluation of the Endeavor Resolute Zotarolimus-Eluting Coronary Stent System in a Real-World Patient Population in China

Conditions:   Ischemic Heart Disease;   Stenotic Coronary Lesion;   Cardiovascular Diseases;   Arteriosclerosis;   Coronary Artery Disease
Intervention:  
Sponsor:   Medtronic Vascular
Active, not recruiting - verified April 2015

Quantitative Imaging and Proton Spectroscopy in Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:   Other: Magnetic Resonance Imaging
Sponsors:   New York University School of Medicine;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Double Blind Combination of Rituximab by Intravenous and Intrathecal Injection Versus Placebo in Patients With Low-Inflammatory Secondary Progressive Multiple Sclerosis (RIVITaLISe)

Condition:   Multiple Sclerosis
Intervention:   Drug: Rituximab
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified October 2014

A Pilot Study of CPAP Adherence Promotion by Peer Buddies With Sleep Apnea

Condition:   Sleep Apnea
Interventions:   Behavioral: Peer-driven intervention;   Other: Usual Care
Sponsor:   Department of Veterans Affairs
Completed - verified February 2013

WalkLink: Internet-based Walking Program

Condition:   Physical Activity
Intervention:   Behavioral: Group
Sponsor:   Milton S. Hershey Medical Center
Completed - verified April 2015

Drug-Eluting Stents vs. Bare Metal Stents In Saphenous Vein Graft Angioplasty

Condition:   Saphenous Vein Graft Atherosclerosis
Interventions:   Device: Bare Metal Stent;   Device: Drug-Eluting Stent;   Drug: Blinded clopidogrel;   Drug: Placebo;   Drug: Thienopyridine (open-label)
Sponsor:   Department of Veterans Affairs
Recruiting - verified April 2015

Phase 3, Randomized, Placebo-Controlled, Double-Blinded Trial of the Combined Lysis of Thrombus With Ultrasound and Systemic Tissue Plasminogen Activator (tPA) for Emergent Revascularization in Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke
Interventions:   Device: Transcranial ultrasound as an adjunctive therapy to tPA;   Drug: Standard of care tPA therapy for acute ischemic stroke
Sponsor:   Cerevast Therapeutics, Inc.
Terminated - verified April 2015

FLOTRAC/VIGILEO in Acute Circulatory Failure

Conditions:   Critically Ill;   Acute Circulatory Failure;   Fluid Loading
Interventions:   Device: Flotrac/Vigileo third generation software;   Device: Transthoracic echocardiography
Sponsor:   Hôpital Européen Marseille
Recruiting - verified April 2015

Troponin T as Risk Stratification Tool in Peripheral Arterial Occlusive Disease

Condition:   Peripheral Arterial Occlusive Disease
Intervention:  
Sponsors:   Heart Center Bad Krozingen;   Johann Wolfgang Goethe University Hospitals
Completed - verified April 2015

PeriOperative ISchemic Evaluation-2 Trial

Condition:   Cardiovascular Disease
Interventions:   Drug: Active Clonidine;   Drug: Placebo Clonidine;   Drug: Active ASA;   Drug: Placebo ASA
Sponsors:   Hamilton Health Sciences Corporation;   McMaster University
Completed - verified April 2015

Hemostatic and Anti-Inflammatory Effects of Ulinastatin and Tranexamic Acid in Cardiopulmonary Bypass Cardiac Surgery

Condition:   Hemostasis
Intervention:   Drug: UTI & TA
Sponsor:   Cardiovascular Institute & Fuwai Hospital
Recruiting - verified April 2015

CANVAS - CANagliflozin cardioVascular Assessment Study

Conditions:   Diabetes Mellitus, Type 2;   Cardiovascular Diseases;   Risk Factors
Interventions:   Drug: Canagliflozin (JNJ-28431754);   Drug: Placebo
Sponsors:   Janssen Research & Development, LLC;   The George Institute for Global Health, Australia
Active, not recruiting - verified April 2015

The PREVENTS Trial: The Preventing Recurrent Events in Veterans Navigating Transient Ischemic Attack (TIA) or Stroke Trial

Conditions:   Stroke;   Transient Ischemic Attack
Interventions:   Behavioral: tailored intervention;   Behavioral: attention placebo
Sponsor:   Narrows Institute for Biomedical Research
Completed - verified April 2015

Navigated Transcranial Magnetic Stimulation in Monitoring Stroke Recovery

Condition:   Ischemic Stroke
Intervention:   Device: Navigated TMS examination
Sponsor:   Nexstim Ltd
Terminated - verified April 2015

Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial

Condition:   Ischemic Attack, Transient
Interventions:   Drug: Clopidogrel;   Drug: placebo
Sponsors:   University of California, San Francisco;   Neurological Emergencies Treatment Trials Network (NETT);   Medical University of South Carolina;   The EMMES Corporation
Recruiting - verified April 2015

Angiotensin-converting-enzyme (ACE) Inhibitors in Hemodialysis

Conditions:   Left Ventricular Hypertrophy;   Hypertension
Interventions:   Drug: ACE inhibitor Ramipril;   Drug: non-RAS inhibitor antihypertensive therapy
Sponsors:   Mario Negri Institute for Pharmacological Research;   Agenzia Italiana del Farmaco
Active, not recruiting - verified April 2015

Efficacy and Cost-Effectiveness of Cost-free Pharmacotherapy for Smoking Cessation for High-risk Smokers With Cerebrovascular Disease

Conditions:   Cerebrovascular Disorders;   Smoking Cessation
Interventions:   Drug: Cost-Free Pharmacotherapy Group;   Other: Prescription Only Group
Sponsors:   Ottawa Heart Institute Research Corporation;   Heart and Stroke Foundation of Ontario
Completed - verified April 2015

Thromboelastography (TEG®) and Platelet Function in Patients on Anti-platelet Agents

Condition:   Blood Clotting
Intervention:   Procedure: blood test
Sponsors:   McMaster University;   University Health Network, Toronto;   Hamilton Health Sciences Corporation
Terminated - verified April 2015

Extending the Time for Thrombolysis in Emergency Neurological Deficits

Condition:   Stroke
Interventions:   Drug: Tissue Plasminogen Activator (Alteplase);   Drug: Placebo
Sponsors:   Neuroscience Trials Australia;   Commonwealth Scientific & Industry Research Organisation;   Brain Research Institute;   University of Melbourne;   Melbourne Health
Recruiting - verified September 2014

Pilot Study of Bumetanide for Newborn Seizures

Condition:   Seizures
Interventions:   Drug: Bumetanide;   Other: Normal Saline
Sponsors:   Soul, Janet , M.D.;   Citizens United for Research in Epilepsy;   Harvard Catalyst- Harvard Clinical and Translational Science Center;   Translational Research Program, Boston Children's Hospital;   Charles H. Hood Foundation;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Comparing the Effectiveness of a Mitral Valve Repair Procedure in Combination With Coronary Artery Bypass Grafting (CABG) Versus CABG Alone in People With Moderate Ischemic Mitral Regurgitation

Conditions:   Mitral Valve Insufficiency;   Coronary Artery Disease
Interventions:   Procedure: Mitral Valve Repair;   Procedure: CABG
Sponsors:   Mount Sinai School of Medicine;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research  (CIHR);   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified April 2015

Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation

Conditions:   Mitral Valve Insufficiency;   Coronary Artery Disease
Interventions:   Procedure: Mitral Valve Repair with Annuloplasty;   Procedure: Mitral Valve Replacement
Sponsors:   Mount Sinai School of Medicine;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research  (CIHR);   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 2015

Sitagliptin Cardiovascular Outcome Study (MK-0431-082)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Sitagliptin phosphate;   Drug: Placebo
Sponsors:   Merck Sharp & Dohme Corp.;   Duke Clinical Research Institute, Oxford Diabetes Trials Unit
Completed - verified April 2015

Electrical Stimulation for Recovery of Hand Function in Chronic Stroke Survivors

Conditions:   Stroke;   Hemiparesis;   Hemiplegia
Intervention:   Device: Electrical stimulator
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting - verified April 2015

Neurobiological Principles Applied to the Rehabilitation of Stroke Patients

Condition:   Stroke
Interventions:   Drug: Sinemet, ritalin, amphetamine,  and placebo;   Device: Transcranial magnetic stimulation (TMS);   Other: Combined drug treatment and TMS
Sponsors:   Emory University;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)

Conditions:   Amyotrophic Lateral Sclerosis;   Lou Gehrig's Disease;   Primary Lateral Sclerosis;   Nervous System Diseases;   Hereditary Spastic Paraparesis
Intervention:   Other: No intervention
Sponsors:   Massachusetts General Hospital;   ALS Association;   ALS Therapy Alliance;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified April 2015

Catheter Ablation vs. Standard Conventional Treatment in Patients With LV Dysfunction and AF

Conditions:   Atrial Fibrillation;   Heart Failure
Interventions:   Procedure: Radiofrequency ablation;   Other: Conventional treatment
Sponsor:   Biotronik SE & Co. KG
Recruiting - verified April 2015

COGNITIVE - Cognitive Function After Sevoflurane or Propofol Anesthesia for Open-heart Operations

Conditions:   Other Functional Disturbances Following Cardiac Surgery;   Memory Disorders
Interventions:   Drug: Diprivan (propofol, Astra Zeneca);   Drug: Sevorane (sevoflurane, Abbott)
Sponsor:   Medical University of Gdansk
Withdrawn - verified April 2015

Vascular Events In Noncardiac Surgery Patients Cohort Evaluation Study (VISION)

Conditions:   Vascular Death;   Myocardial Infarction;   Cardiac Arrest;   Stroke
Intervention:  
Sponsors:   Hamilton Health Sciences Corporation;   Roche Diagnostic Ltd.;   Heart and Stroke Foundation of Ontario;   Population Health Research Institute;   Ontario Ministry of Research and Innovation;   McMaster University;   CLARITY Group
Completed - verified April 2015

Preventing ESRD in Overt Nephropathy of Type 2 Diabetes

Condition:   Diabetes
Interventions:   Drug: Benazepril;   Drug: Valsartan;   Drug: Benazepril/Valsartan
Sponsors:   Mario Negri Institute for Pharmacological Research;   Agenzia Italiana del Farmaco
Active, not recruiting - verified April 2015

Anticoagulation in Blunt Cerebrovascular Injuries

Conditions:   Carotid Artery Injury;   Vertebral Artery Injury
Interventions:   Drug: heparin;   Drug: aspirin and clopidogrel
Sponsor:   C. Clay Cothren, MD
Withdrawn - verified April 2015

Effect of Diet on Vascular Disease in Pre-Menopausal Women

Conditions:   Cardiovascular Diseases;   Vascular Disease;   Inflammation;   Insulin;   Triglycerides
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed - verified March 2015

Heart Outcomes Prevention Evaluation-3

Conditions:   Cardiovascular Disease;   Stroke
Interventions:   Drug: Candesartan/HCT;   Drug: Rosuvastatin
Sponsor:   Population Health Research Institute
Active, not recruiting - verified April 2015

Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies

Conditions:   Aphasia;   Nonfluent Aphasia;   Stroke
Intervention:  
Sponsors:   Department of Veterans Affairs;   Boston University
Recruiting - verified April 2015

PERIOP 2 - A Safety and Effectiveness Study of LMWH Bridging Therapy Versus Placebo Bridging Therapy for Patients on Long Term Warfarin and Require Temporary Interruption of Their Warfarin.

Condition:   Stroke
Interventions:   Drug: Dalteparin;   Other: Placebo
Sponsors:   Lawson Health Research Institute;   Canadian Institutes of Health Research  (CIHR);   Pfizer
Recruiting - verified April 2015

Mental Imagery to Reduce Motor Deficits in Stroke

Condition:   Stroke
Interventions:   Behavioral: Mental Imagery only;   Procedure: Mental Imagery and Constraint induced therapy
Sponsor:   Emory University
Completed - verified April 2015

The Effect of Insulin on Infarct Size and Neurologic Outcome After Acute Stroke

Conditions:   Ischemic Stroke;   Hyperglycemia
Intervention:   Drug: Insulin
Sponsor:   Temple University
Completed - verified April 2015

Effects Of Atorvastatin On Macrophage Activity And Plaque Inflammation Using Magnetic Resonance Imaging

Conditions:   Atherosclerotic Carotid Disease;   Atheroma;   Atherosclerosis
Intervention:   Drug: atorvastatin
Sponsor:   GlaxoSmithKline
Completed - verified April 2015

Vision Testing in Patients With Partial Seizures Receiving Either Lyrica or Placebo

Condition:   Epilepsies, Partial
Interventions:   Drug: Lyrica (pregabalin);   Drug: placebo
Sponsor:   Pfizer
Recruiting - verified April 2015

Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen

Condition:   Arthritis, Rheumatoid
Interventions:   Drug: celecoxib;   Drug: Ibuprofen;   Drug: Naproxen
Sponsors:   Pfizer;   The Cleveland Clinic
Active, not recruiting - verified April 2015

Veteran-Centered Outcomes Using Qualitative and Quantitative Methods

Conditions:   Spinal Cord Injury;   Stroke
Intervention:  
Sponsor:   Department of Veterans Affairs
Completed - verified April 2015

Registry of Unexplained Cardiac Arrest

Conditions:   Cardiac Arrest;   Long QT Syndrome;   Brugada Syndrome;   Catecholaminergi Polymorphic Ventricular Tachycardia;   Idiopathic VentricularFibrillation;   Early Repolarization Syndrome;   Arrhythmogenic Right Ventricular Cardiomyopathy
Intervention:  
Sponsors:   University of British Columbia;   Heart and Stroke Foundation of Ontario;   Boston Scientific Corporation;   Medtronic
Recruiting - verified April 2015

Evaluation of a Web-based Intervention to Promote Physical Activity in Patients With Heart Disease.

Condition:   Coronary Artery Disease (CAD)
Intervention:   Behavioral: CardioFit
Sponsors:   Ottawa Heart Institute Research Corporation;   Heart and Stroke Foundation of Ontario
Completed - verified March 2009

Effect of Sarpogrelate on Platelet Aggregation in Patients With Cerebral Infarction: Dose-responsive Clinical Pharmacology Study

Condition:   Cerebral Infarction
Intervention:   Drug: MCI-9042
Sponsor:   Mitsubishi Tanabe Pharma Corporation
Completed - verified April 2015

Training for Diagnosing Neurological Disorders

Condition:   Musculoskeletal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2015

Measuring Health Related Quality of Life in Veterans With Stroke

Conditions:   Stroke;   Quality of Life;   Rehabilitation
Intervention:  
Sponsor:   Department of Veterans Affairs
Completed - verified January 2005

CONCEPT: Crossover Efficacy Pain Trial in Motor Cortex Stimulation for Intractable Neuropathic Pain

Conditions:   Pain, Intractable;   Facial Pain
Intervention:   Device: Cortical lead, 8 electrodes (Model 2976) with Synergy neurostimulator
Sponsor:   Medtronic
Terminated - verified April 2015

Myotonic Dystrophy and Facioscapulohumeral Muscular Dystrophy Registry

Conditions:   Myotonic Dystrophy;   Muscular Dystrophy, Facioscapulohumeral;   Muscular Dystrophy
Intervention:  
Sponsors:   University of Rochester;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Measuring Levels of SMN in Blood Samples of SMA Patients

Condition:   Spinal Muscular Atrophy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified March 2015

Guidelines for Drug Therapy of Hypertension: Closing the Loop

Condition:   Hypertension
Intervention:   Procedure: Computer generated statements about guideline concordance of drug therapy deliver to clinicians
Sponsors:   Department of Veterans Affairs;   Stanford University
Completed - verified February 2007

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