Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Effects of Prism Adaption and rTMS on Brain Connectivity and Visual Representation

Conditions:   Normal Physiology;   Stroke
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2016

Cerebral Perfusion Associated With Postural Changes: an ASL MR Perfusion Study

Condition:   Brain Ischemia
Intervention:   Procedure: MRI
Sponsor:   University Hospital Center of Martinique
Not yet recruiting - verified September 2016

Magnesium And Verapamil After Recanalization in Ischemia of the Cerebrum: a Clinical and Translational Study.

Condition:   Ischemic Stroke
Interventions:   Drug: Verapamil and Magnesium Sulfate;   Other: Placebo
Sponsor:   Justin Fraser
Not yet recruiting - verified September 2016

Reaching in Stroke 3rd Phase

Condition:   Stroke
Interventions:   Other: Visual + Force Feedback;   Other: Visual + Force + Game Scores Feedback
Sponsors:   University of British Columbia;   Networks of Centres of Excellence Canada;   Natural Sciences and Engineering Research Council, Canada;   UBC Faculty of Graduate and Postdoctoral Studies
Recruiting - verified September 2016

Multi-channel Stimulation for Post Stroke Spasticity (MUSTS)

Conditions:   Muscle Spasticity;   Stroke
Interventions:   Device: ShefStim;   Device: Electrodes
Sponsor:   Sheffield Teaching Hospitals NHS Foundation Trust
Not yet recruiting - verified September 2016

Music and Adherence Home Programs Post Stroke

Condition:   Stroke
Intervention:   Behavioral: Preferred music playlist
Sponsor:   Duquesne University
Recruiting - verified September 2016

Genetic, Metabolic, and Growth Factor Repository for Cerebrovascular Disorders

Conditions:   Cerebrovascular Diseases;   Ischemic Stroke;   Repository
Intervention:  
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified September 2016

Efficacy and Safety of Young Health Plasma on Acute Stroke

Condition:   Stroke
Interventions:   Drug: young Fresh Frozen Plasma;   Drug: old Fresh Frozen Plasma
Sponsor:   Xinqiao Hospital of Chongqing
Not yet recruiting - verified September 2016

Deep Brain Stimulation Surgery for Focal Hand Dystonia

Conditions:   Dystonia;   Focal Dystonia;   Musician's Dystonia
Intervention:   Procedure: DBS surgery
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified August 2016

Outdoor Walking and Strength Training After Acute Stroke or Transient Ischemic Attack.

Conditions:   Acute Stroke;   TIA (Transient Ischemic Attack)
Intervention:   Other: Outdoor walking and strength exercise
Sponsor:   Uppsala County Council, Sweden
Not yet recruiting - verified September 2016

The Effect of Intervention With Potassium and/ or Magnesium-enriched Salt on Neurological Performance of Stroke Patients

Condition:   Stroke
Interventions:   Other: Regular salt;   Other: Potassium-enriched salt;   Other: Potassium and magnesium-enriched salt
Sponsor:   Academia Sinica, Taiwan
Completed - verified September 2016

Colchicine for Prevention of Vascular Inflammation in Non-cardio Embolic Stroke

Conditions:   Ischemic Attack, Transient;   Stroke
Intervention:   Drug: Colchicine
Sponsors:   University College Dublin;   Health Research Board, Ireland;   Irish Heart Foundation;   University of Limerick;   University of Edinburgh;   National University of Ireland, Galway, Ireland;   Universitat de Lleida;   Universitaire Ziekenhuizen Leuven;   University of Athens
Not yet recruiting - verified September 2016

Theta-Burst-Stimulation in Early Rehabilitation of Stroke

Condition:   Stroke
Interventions:   Device: Magstim Super Rapid2 System, intermittent theta-burst-stimulation (iTBS) protocol;   Device: Magstim Super Rapid2 System, sham-stimulation (in iTBS)
Sponsor:   University of Cologne
Recruiting - verified September 2016

Interest of Thromboelastography (ROTEM) as a Biomarker of Revascularisation in Stroke

Condition:   Stroke
Intervention:   Biological: Thromboelastography
Sponsor:   University Hospital, Caen
Recruiting - verified September 2016

Frailty as an INstrument for Evaluation of Elderly Patients With Non ST ElevationMyocardial Infarction (NSTEMI) - 5 Year Follow up

Conditions:   Non ST Elevation Myocardial Infarction (NSTEMI);   Frailty
Intervention:   Other: This is an observational study
Sponsor:   Linkoeping University
Not yet recruiting - verified September 2016

SDM for Stroke Prevention in Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Behavioral: Decision Aid
Sponsors:   Mayo Clinic;   Park Nicollet Clinic;   Hennepin County Medical Center, Minneapolis
Not yet recruiting - verified September 2016

Estrogen Receptor Antagonist in Patients With Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Fulvestrant
Sponsor:   University of Pennsylvania
Not yet recruiting - verified September 2016

Impact of Neutrophil Extracellular Traps on Tissue Plasminogen Activator Induced Thrombolysis in Acute Ischemic Stroke Patients

Condition:   Acute Stroke
Intervention:  
Sponsor:   Fondation Ophtalmologique Adolphe de Rothschild
Recruiting - verified September 2016

Effect of Body Representation in Movement

Condition:   Stroke
Interventions:   Behavioral: Magnification hand size;   Device: magnifying lenses
Sponsors:   University of Pennsylvania;   Moss Rehabilitation Research Institute
Enrolling by invitation - verified September 2016

Non-vitamin K Oral Anticoagulants in Cardioversion

Condition:   Atrial Fibrillation
Intervention:  
Sponsors:   Helsinki University Central Hospital;   University of Turku
Completed - verified September 2016

The KHENERGY Study

Conditions:   Mitochondrial Diseases;   Mitochondrial Myopathies;   Mitochondrial Encephalomyopathies;   MELAS;   MIDD
Interventions:   Drug: KH176;   Drug: placebo
Sponsors:   Khondrion BV;   Radboud Center for Mitochondrial Medicine (RCMM);   Radboud University
Recruiting - verified September 2016

The Effect of Exercise on Physical Function and Health in Older People After Discharge From Hospital

Conditions:   Chest Pain;   Pneumonia;   Transient Ischemic Attack;   Stroke;   Functional Failure
Intervention:   Other: Exercise
Sponsor:   Oslo and Akershus University College of Applied Sciences
Recruiting - verified September 2016

Inter-Hospital Transfer to a Vascular Neurology Unit After Telethrombolysis

Condition:   Ischemic Stroke
Intervention:  
Sponsor:   Centre Hospitalier Universitaire de Besancon
Completed - verified September 2016

Mental Practice Combined With Physical Practice Training for Gait Improvement in Parkinson's Disease Patients

Condition:   Parkinson Disease
Interventions:   Behavioral: Mental Practice training;   Behavioral: Physical Practice training;   Behavioral: Control training
Sponsor:   University of Sao Paulo General Hospital
Completed - verified September 2016

n-Butylphthalide (NBP) Softgel Capsules in Stroke Patients

Condition:   AIS
Interventions:   Drug: NBP Softgel Capsules;   Drug: Placebo;   Drug: Aspirin
Sponsor:   CSPC-NBP Pharmaceutical Co., Ltd.
Not yet recruiting - verified August 2016

Safety and Efficacy of Honeycomb Microporous Covered Stents (NCVC-CS1) for the Treatment of Intracranial Aneurysms

Condition:   Intracranial Aneurysm
Intervention:   Device: NCVC-CS1
Sponsors:   National Cerebral and Cardiovascular Center;   Kobe City Medical Center General Hospital;   Juntendo University Hospital
Recruiting - verified September 2016

Intrathecal Baclofen (ITB) Delivery Location and Its Effect on Spasticity

Condition:   Muscle Spasticity
Intervention:   Drug: Baclofen bolus injection
Sponsors:   Vanderbilt University;   Medtronic
Recruiting - verified September 2016

Optimal Coronary Flow After PCI for Myocardial Infarction - a Pilot Study

Condition:   ST-segment Elevation Myocardial Infarction
Interventions:   Drug: alteplase;   Drug: Placebo
Sponsor:   Vastra Gotaland Region
Recruiting - verified June 2016

Efficacy of Furosemide Versus Vascular Filling in Patients With Acute Myocardial Infarction

Condition:   Acute Myocardial Infarction With Right Ventricular Extension
Interventions:   Drug: Furosemide;   Drug: Placebo filling;   Drug: Placebo furosemide;   Drug: Vascular filling
Sponsor:   Assistance Publique - Hôpitaux de Paris
Not yet recruiting - verified July 2016

Assessment of Volumetric Hemodynamic Parameters and Nutritional Status in Stable Renal Transplant Recipients

Conditions:   Cardiac Output, Low;   High Blood Pressure
Interventions:   Device: CardioScreen 1000;   Device: Tanita 418- Bioelectrical impedance analysis
Sponsor:   Medical University of Warsaw
Completed - verified September 2016

Safety and Efficacy of IV TXA in Reducing Blood Loss and Transfusion in Hip Fractures

Conditions:   Hip Fractures;   Blood Loss
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsor:   Yale University
Not yet recruiting - verified September 2016

The Effect of GLP-1 Receptor Agonist on Cerebral Blood Flow Velocity in Non-stroke Volunteers

Condition:   Stroke
Interventions:   Drug: Byetta;   Drug: Isotonic saline
Sponsor:   Christina Kruuse
Recruiting - verified September 2016

Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis

Condition:   Ischemic Stroke
Interventions:   Drug: Intravenous recombinant tissue plasminogen activator (rtPA) Alteplase;   Drug: Intravenous Tenecteplase
Sponsors:   NHS Greater Glasgow and Clyde;   University of Glasgow;   University of Edinburgh;   Oxford University Hospitals NHS Trust
Not yet recruiting - verified September 2016

Patient Education Following a Stroke

Condition:   Stroke
Intervention:   Behavioral: stroke education workshops
Sponsor:   Hopital Foch
Active, not recruiting - verified June 2016

Superselective Citicoline and Verapamil for Ischemic Neuroprotection and Greater Effective Response

Condition:   Ischemic Stroke
Interventions:   Drug: Verapamil and Citicoline;   Other: Placebo
Sponsor:   Justin Fraser
Withdrawn - verified September 2016

CADASIL Disease Discovery

Conditions:   Cardiovascular Disease;   Arterial Stiffness
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified September 2016

Treatment Convenience in Patients Treated With Dabigatran for Stroke Prophylaxis in Atrial Fibrillation (SPAF)

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified September 2016

A New Interdisciplinary Collaboration Structure to Improve Medication Safety in the Elderly

Conditions:   Health Services for the Aged;   Medication Therapy Management
Intervention:   Other: Interdisciplinary collaboration structure
Sponsors:   University of Tromso;   University Hospital of North Norway
Not yet recruiting - verified September 2016

Patient Reported Outcomes Measures (PROM) in Carpal Tunnel Therapies in Patients With Inherited Neuropathies

Conditions:   Carpal Tunnel Syndrome;   Charcot-Marie-Tooth Disease;   Inherited Peripheral Neuropathy
Intervention:   Other: Web-based survey
Sponsors:   University of South Florida;   National Institute of Neurological Disorders and Stroke (NINDS);   University of Rochester;   University of Iowa
Recruiting - verified September 2016

A Study to Evaluate the Efficacy and Safety of TF0023 Spray on Subjects With Ischemic Strokes

Condition:   Ischemic Stroke
Intervention:   Drug: TF0023
Sponsor:   Techfields Inc
Recruiting - verified September 2016

Motor Imagery Training in Persons With Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:   Other: Motor imagery training
Sponsor:   Dokuz Eylul University
Recruiting - verified September 2016

STrategic Reperfusion in Elderly Patients Early After Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Drug: Tenecteplase;   Drug: Clopidogrel;   Procedure: Coronary angiography;   Procedure: Primary PCI
Sponsors:   Katholieke Universiteit Leuven;   Boehringer Ingelheim;   Life Sciences Research Partners;   Fund for Clinical Cardiovascular Research at LRD
Not yet recruiting - verified September 2016

Patient Convenience Study- NIS RELATE

Condition:   Atrial Fibrillation
Interventions:   Drug: Pradaxa (dabigatran);   Drug: Vitamin K antagonist
Sponsor:   Boehringer Ingelheim
Recruiting - verified September 2016

Low-frequency Pulsed Electromagnetic Fields (ELF-MF) as Treatment for Acute Ischemic Stroke

Conditions:   Stroke, Acute;   Ischemic Stroke
Interventions:   Device: REAL Pulsed ELF-MF stimulation;   Device: SHAM Pulsed ELF-MF stimulation
Sponsors:   Campus Bio-Medico University;   Nuovo Ospedale Civile S.Agostino Estense;   San Raffaele University Hospital, Italy;   University Hospital of Ferrara
Recruiting - verified September 2016

Xarelto on Prevention of Stroke and Non-central Nervous System Systemic Embolism in Patients With Non-valvular Atrial Fibrillation in China: A Non-interventional Study

Condition:   Stroke
Intervention:   Drug: Rivaroxaban (Xarelto, BAY 59-7939)
Sponsor:   Bayer
Recruiting - verified September 2016

A Study to Assess Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)

Condition:   Duchenne Muscular Dystrophy
Interventions:   Drug: Vamorolone 0.25 mg/kg/day;   Drug: Vamorolone 0.75 mg/kg/day;   Drug: Vamorolone 2.0 mg/kg/day;   Drug: Vamorolone 6.0 mg/kg/day
Sponsors:   ReveraGen BioPharma, Inc.;   University of Pittsburgh;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS);   National Institute of Neurological Disorders and Stroke (NINDS);   Cooperative International Neuromuscular Research Group
Recruiting - verified September 2016

An Extension Study to Assess Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)

Condition:   Duchenne Muscular Dystrophy
Interventions:   Drug: Vamorolone 0.25 mg/day/day;   Drug: Vamorolone 0.75 mg/day/day;   Drug: Vamorolone 2.0 mg/day/day;   Drug: Vamorolone 6.0 mg/day/day
Sponsors:   ReveraGen BioPharma, Inc.;   University of Pittsburgh;   National Institute of Neurological Disorders and Stroke (NINDS);   Cooperative International Neuromuscular Research Group;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified September 2016

The Medtronic TAVR 2.0 US Clinical Study

Condition:   Aortic Valve Stenosis
Intervention:   Device: Medtronic Transcatheter Aortic Valve 2.0 Replacement System
Sponsor:   Medtronic Cardiovascular
Recruiting - verified September 2016

Multifocal Brain Magnetic Stimulation in Chronic Ischemic Stroke

Condition:   Stroke
Intervention:   Device: Transcranial magnetic stimulation
Sponsors:   David Chiu, MD;   Houston Methodist Research Institute
Enrolling by invitation - verified September 2016

CT COMPARE: CT COronary Angiography to Measure PlAque REduction

Condition:   Cardiovascular Disease
Interventions:   Drug: Rosuvastatin;   Drug: Atorvastatin
Sponsor:   National Institutes of Health Clinical Center (CC)
Recruiting - verified September 2016

Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy With Ex Vivo Generated Polyomavirus-Specific T-Cells

Condition:   Leukoencephalopathy
Interventions:   Biological: PyVST;   Other: No Intervention
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2016

Study Evaluating the MindMotionPRO for Early Post-stroke Upper-limb Rehabilitation

Conditions:   Stroke;   Motor Disorders
Interventions:   Device: MindMotionPRO;   Other: Self-Directed Prescribed Exercises
Sponsor:   Mindmaze SA
Recruiting - verified September 2016

Mindful Meditation for Chronic Stroke

Condition:   Stroke
Interventions:   Behavioral: Otago Exercise program;   Behavioral: Mindful meditation
Sponsor:   University of British Columbia
Completed - verified September 2016

Remote Ischaemic Conditioning After Stroke Trial (ReCAST-2)

Condition:   Stroke
Interventions:   Procedure: Remote ischaemic conditioning;   Procedure: Sham
Sponsor:   University of Nottingham
Recruiting - verified September 2016

Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

Condition:   Aortic Valve Stenosis
Interventions:   Device: SAPIEN 3 THV;   Biological: Optimal Heart Failure Therapy
Sponsors:   Cardiovascular Research Foundation, New York;   Cardialysis BV;   Boston Biomedical Associates LLC
Recruiting - verified September 2016

STAT-STatin and Aspirin in Trauma

Conditions:   Wounds and Injuries;   Venous Thromboembolism
Interventions:   Drug: Aspirin and Rosuvastatin;   Drug: Placebo (for Aspirin and Rosuvastatin)
Sponsor:   Denver Health and Hospital Authority
Not yet recruiting - verified September 2016

Reaching in Stroke

Condition:   Stroke
Interventions:   Other: Visual Feedback;   Other: Force Feedback
Sponsors:   University of British Columbia;   UBC Peter Wall Institute for Advanced Studies;   National Council of Science and Technology, Mexico
Completed - verified September 2016

Effectiveness of Virtual Reality Gaming Therapy Versus CI Therapy for Upper Extremity Rehabilitation

Conditions:   Stroke;   Hemiparesis
Interventions:   Behavioral: Traditional CI Therapy;   Behavioral: Gaming CI Therapy;   Behavioral: Gaming CI Therapy with Additional Contact via Video Conference;   Behavioral: Traditional Occupational Therapy/Physical Therapy
Sponsors:   Ohio State University;   OhioHealth;   Providence Medford Medical Center;   University of Alabama at Birmingham
Recruiting - verified September 2016

Length of Stay in NVAF Patients Hospitalized and Initiated With Dabigatran or Warfarin in Japan

Condition:   Atrial Fibrillation
Interventions:   Drug: Dabigatran;   Drug: Wafrarin
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified September 2016

Tranexamic Acid for Acute ICH Growth prEdicted by Spot Sign

Conditions:   Intracerebral Hemorrhage;   Stroke
Intervention:   Drug: Tranexamic Acid
Sponsors:   Ministry of Science and Technology of the People´s Republic of China;   Beijing Municipal Science & Technology Commission
Recruiting - verified September 2016

Study of Urate Elevation in Parkinson's Disease, Phase 3

Condition:   Parkinson's Disease
Interventions:   Drug: Inosine;   Drug: Placebo
Sponsors:   Michael Alan Schwarzschild;   The Parkinson Study Group;   Michael J. Fox Foundation for Parkinson's Research;   University of Rochester;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2016

A Study to Compare Tivozanib Hydrochloride to Sorafenib in Subjects With Refractory Advanced RCC

Condition:   Carcinoma, Renal Cell
Interventions:   Drug: tivozanib hydrochloride;   Drug: Sorafenib
Sponsor:   AVEO Pharmaceuticals, Inc.
Recruiting - verified September 2016

Feasibility of Transcatheter Aortic Valve Replacement in Low-Risk Patients With Symptomatic, Severe Aortic Stenosis

Condition:   Aortic Stenosis
Interventions:   Device: Transfemoral TAVR;   Device: SAVR
Sponsor:   Medstar Health Research Institute
Recruiting - verified September 2016

Patient Convenience Study (RE-SONANCE)

Conditions:   Atrial Fibrillation;   Stroke
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified September 2016

Glutamate for Metabolic Intervention in Coronary Surgery II

Conditions:   Coronary Artery Bypass Surgery;   Postoperative Complications;   Heart Failure
Interventions:   Drug: glutamate infusion;   Drug: saline infusion
Sponsors:   University Hospital, Linkoeping;   Region Örebro County;   University Hospital, Umeå;   Sahlgrenska University Hospital, Sweden;   Blekinge County Council Hospital
Recruiting - verified September 2016

Changes in Echogenicity and Muscle Stiffness in Elastography After Botulinum Toxin Injection a Spastic Muscle

Condition:   Stroke
Interventions:   Device: ultrasound echogenicity;   Device: elastography
Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
Terminated - verified September 2016

Apixaban in Atrial Fibrillation Registry

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   IHF GmbH - Institut für Herzinfarktforschung
Recruiting - verified September 2016

Epidemiological Study on the Safety of Aspirin in The Health Improvement Network (THIN)

Conditions:   Secondary Prevention;   Stroke;   Ischemic Heart Disease;   Coronary Heart Disease
Interventions:   Drug: Acetylsalicylic Acid (Asprin, BAYE4465);   Drug: Clopidogrel, Oral Anticoagulants, NSAIDs and SSRIs
Sponsor:   Bayer
Recruiting - verified September 2016

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified September 2016

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified September 2016

Novel Treatment For Pusher Syndrome Using Physical Therapy

Condition:   Pusher Syndrome
Interventions:   Other: Novel physical therapy;   Other: Standard physical therapy
Sponsor:   Loma Linda University
Enrolling by invitation - verified September 2016

Sideways Treadmill Training to Improve Paretic Leg Stepping in Persons Post-Stroke

Conditions:   Stroke;   Hemiparesis
Intervention:   Behavioral: treadmill training
Sponsor:   Northwestern University
Recruiting - verified September 2016

High Versus Low SpO2 Oxygen Therapy in Patients With Acute Heart Failure

Condition:   Heart Failure
Interventions:   Other: High SpO2;   Other: Low SpO2
Sponsors:   University of Alberta;   Heart and Stroke Foundation of Canada;   Alberta Innovates Health Solutions
Not yet recruiting - verified September 2016

Analysis of Revascularization in Ischemic Stroke With EmboTrap

Conditions:   Stroke;   Ischemia
Intervention:   Device: EmboTrap® Revascularization Device
Sponsor:   Neuravi Inc.
Recruiting - verified September 2016

Validation of Nicom Device to Measure Stoke Volume Variation

Condition:   Anesthesia
Interventions:   Procedure: Volume loading;   Drug: Ringer solution
Sponsor:   Hopital Foch
Recruiting - verified April 2016

Perioperative Goal Directed Hemodynamic Therapy Based on Noninvasive Monitoring in Patients With Hip Fracture

Condition:   Hip Fractures
Interventions:   Other: PGDT based on noninvasive monitoring;   Device: System ClearSight® and Platform EV Clinic 1000®
Sponsor:   Althaia Xarxa Assistencial Universitària de Manresa
Recruiting - verified September 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsor:   Bayer
Recruiting - verified September 2016

WATCHMAN Implantation During Hybrid Ablation

Conditions:   Atrial Fibrillation;   Stroke
Intervention:   Device: WATCHMAN Device implantation
Sponsors:   Maastricht University Medical Center;   Boston Scientific Corporation
Recruiting - verified September 2016

Amplatzer™Amulet™ Post-Market Study

Conditions:   Atrial Fibrillation;   Thromboembolism;   Stroke
Intervention:   Device: Subjects implanted with Amulet Device
Sponsor:   St. Jude Medical
Recruiting - verified July 2016

Michigan Stroke Transitions Trial

Condition:   Acute Stroke
Interventions:   Other: SCM;   Other: SCM and VSSP
Sponsors:   Michigan State University;   University of Michigan;   Saint Joseph Mercy Health System;   McLaren Health Care;   Sparrow Health System;   Massachusetts General Hospital
Recruiting - verified September 2016

Canadian Pradaxa Acute Stroke Safety Study

Conditions:   Ischemic Attack, Transient;   Stroke
Intervention:   Drug: Dabigatran
Sponsors:   University of Alberta;   Boehringer Ingelheim
Recruiting - verified September 2016

tDCS and Speech Therapy to Improve Aphasia

Conditions:   Aphasia, Global;   Stroke;   Transcranial Direct Current Stimulation;   Speech Therapy
Intervention:   Procedure: tDCS + speech therapy
Sponsor:   Medical Park AG
Recruiting - verified September 2016

Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: Tenecteplase;   Drug: Tissue Plasminogen Activator
Sponsors:   Neuroscience Trials Australia;   The Florey Institute of Neuroscience and Mental Health
Recruiting - verified September 2016

Effect of Serotonin and Levodopa in Ischemic Stroke

Condition:   Stroke
Interventions:   Other: placebo;   Drug: citalopram;   Drug: sinemet plus
Sponsor:   Hospital de Granollers
Recruiting - verified September 2016

Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy

Conditions:   Giant Axonal Neuropathy;   Gene Transfer
Intervention:   Drug: Intrathecal Delivery of scAAV9/JeT-GAN
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2016

Effectiveness of VistaO2 FLUX Device in Screening of Sleep Apnea/Hypopnea Syndrome

Condition:   Sleep Apnea Syndromes
Intervention:   Device: VistaO2 FLUX device
Sponsors:   Centre Hospitalier Universitaire de Saint Etienne;   Novacor
Recruiting - verified September 2016

Uninterrupted Dabigatran Etexilate in Comparison to Uninterrupted Warfarin in Pulmonary Vein Ablation (RE-CIRCUIT)

Condition:   Atrial Fibrillation
Interventions:   Drug: Warfarin;   Drug: Dabigatran Etexilate 150mg
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified September 2016

Neuroform Atlas IDE Study

Condition:   Intracranial Aneurysm
Intervention:   Device: Next Generation Neuroform Stent System
Sponsor:   Stryker Neurovascular
Recruiting - verified August 2016

Weight Loss Referral for Healthier Survivorship in Obese Stage I-II Endometrial Cancer Survivors or Atypical Hyperplasia

Conditions:   Complex Endometrial Hyperplasia With Atypia;   Stage IA Uterine Corpus Cancer;   Stage IB Uterine Corpus Cancer;   Stage II Uterine Corpus Cancer
Interventions:   Behavioral: Weight Loss Specialist;   Other: Quality-of-Life Assessment;   Other: Medical Chart Review
Sponsors:   Case Comprehensive Cancer Center;   National Cancer Institute (NCI)
Active, not recruiting - verified September 2016

Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion

Conditions:   Nervous System Disorders;   Cerebral Artery
Interventions:   Drug: rt-PA;   Drug: tenecteplase
Sponsor:   University Hospital Center of Martinique
Not yet recruiting - verified September 2016

Syncardia 50cc TAH-t as a Bridge to Transplant

Conditions:   Heart Failure, Right-Sided;   Cardiac Failure;   Heart Failure, Left-Sided
Intervention:   Device: SynCardia 50cc temporary Total Artificial Heart (TAH-t)
Sponsor:   SynCardia Systems. Inc.
Recruiting - verified January 2016

Bivalirudin vs Heparin in NSTEMI and STEMI in Patients on Modern Antiplatelet Therapy in SWEDEHEART

Conditions:   ST-segment Elevation Myocardial Infarction;   Non ST-segment Elevation Myocardial Infarction
Interventions:   Drug: bivalirudin;   Drug: Heparin
Sponsors:   Uppsala University;   Lund University
Active, not recruiting - verified September 2016

Apixaban for Early Prevention of Recurrent Embolic Stroke and Hemorrhagic Transformation

Conditions:   Transient Ischemic Attack;   Stroke;   Atrial Fibrillation
Interventions:   Drug: Apixaban;   Drug: Warfarin
Sponsors:   University of South Florida;   Bristol-Myers Squibb
Recruiting - verified September 2016

The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial II

Condition:   Intracerebral Hemorrhage
Intervention:   Drug: labetalol/hydralazine/enalapril
Sponsor:   University of Alberta
Recruiting - verified September 2016

Fit For Function: A Community Wellness Program for Persons With Stroke

Condition:   Cerebrovascular Accident
Interventions:   Other: Fit For Function Program;   Other: Standard YMCA membership
Sponsors:   McMaster University;   Canadian Institutes of Health Research (CIHR);   YMCA of Hamilton/Burlington/Brant;   YMCA of Niagara;   Brant Community Healthcare System;   Niagara Health System;   Hamilton Health Sciences Corporation
Recruiting - verified September 2016

Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System

Condition:   Mitral Valve Regurgitation
Intervention:   Device: Mitral valve replacement
Sponsor:   Neovasc Inc.
Recruiting - verified September 2016

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified September 2016

Effects of Proximal and Distal Robot-assisted Therapy Combined With Functional Training

Condition:   Stroke
Interventions:   Device: proximal robot-assisted therapy;   Device: distal robot-assisted therapy;   Behavioral: individualized intensive therapy
Sponsor:   Chang Gung Memorial Hospital
Completed - verified September 2016

Drug Persistence/Adherence in Patients Treated With Dabigatran or VKA for Stroke Prevention in Non Valvular Atrial Fibrillation (SPAF)

Condition:   Atrial Fibrillation
Interventions:   Drug: Dabigatran etexilate;   Drug: Phenprocoumon
Sponsor:   Boehringer Ingelheim
Recruiting - verified September 2016

Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

Conditions:   Stroke;   Secondary Prevention
Interventions:   Drug: optional ASA as comedication;   Drug: placebo to ASA;   Drug: placebo to optional ASA as comedication;   Drug: placebo to dabigatran etexilate;   Drug: ASA 100 mg;   Drug: dabigatran etexilate
Sponsor:   Boehringer Ingelheim
Recruiting - verified September 2016

Monitoring Everyday Life Motor Activity in Children

Condition:   Neurologic Disorders
Intervention:  
Sponsor:   Rob Labruyere
Recruiting - verified September 2016

Brazilian Intervention to Increase Evidence Usage in Practice - Stroke ( BRIDGE-Stroke)

Condition:   Acute Ischemic Stroke
Intervention:   Behavioral: Multifaceted Strategy
Sponsor:   Hospital do Coracao
Recruiting - verified September 2016

SynCardia 70cc TAH-t for Destination Therapy (DT)

Conditions:   Life-threatening;   Biventricular Heart Failure;   Ineligible for Cardiac Transplant
Intervention:   Device: 70cc TAH-t for Destination Therapy
Sponsor:   SynCardia Systems. Inc.
Recruiting - verified January 2016

Active Surveillance Research Program for the Assessment of the Safety and the Effectiveness of Linagliptin

Condition:   Diabetes Mellitus, Type 2
Intervention:  
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified September 2016

BEnefits of Stroke Treatment Delivered Using a Mobile Stroke Unit

Condition:   Acute Ischemic Stroke
Intervention:   Other: Mobile Stroke Unit Management
Sponsors:   Memorial Hermann Health System;   The University of Texas Health Science Center, Houston;   Baylor College of Medicine;   CHI St. Luke's Health, Texas;   City of Houston Fire Department;   The Methodist Hospital System;   West University Fire Department;   City of Bellaire Fire Department;   Ben Taub Hospital;   Harris Health
Recruiting - verified September 2016

Analysis of Revascularisation in Ischemic Stroke With EmboTrap

Condition:   Ischemic Stroke
Intervention:   Device: EmboTrap® Revascularization Device
Sponsor:   Neuravi Limited
Active, not recruiting - verified September 2016

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease, on Dialysis

Condition:   Anemia
Interventions:   Drug: Roxadustat;   Drug: Epoetin alfa
Sponsors:   AstraZeneca;   FibroGen
Recruiting - verified September 2016

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease (CKD), Not on Dialysis

Condition:   Anemia
Interventions:   Drug: Roxadustat;   Drug: Placebo
Sponsors:   AstraZeneca;   FibroGen
Recruiting - verified September 2016

Evaluation of the ReVive SE Device for Intra-Arterial Thrombectomy in Acute Ischemic Stroke

Condition:   Stroke
Intervention:  
Sponsor:   Codman & Shurtleff
Recruiting - verified September 2016

REmote iSchemic Conditioning in acUtE BRAin INfarction Study

Condition:   Cerebral Infarction
Interventions:   Device: Lower limb tourniquet;   Other: Usual care
Sponsors:   Versailles Hospital;   Unité de Recherche Clinique Paris IDF Ouest
Recruiting - verified September 2016

Xanthine Oxidase Inhibition for Improvement of Long-term Outcomes Following Ischaemic Stroke and Transient Ischaemic Attack

Condition:   Ischaemic Stroke
Interventions:   Drug: Allopurinol;   Drug: Placebo
Sponsors:   NHS Greater Glasgow and Clyde;   University of Glasgow
Recruiting - verified September 2016

Pilot Investigation of Stem Cells in Stroke Phase II Efficacy

Conditions:   Ischaemic Stroke;   Cerebral Infarction;   Hemiparesis;   Arm Paralysis
Intervention:   Biological: CTX DP
Sponsor:   ReNeuron Limited
Active, not recruiting - verified September 2016

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy;   Device: Carotid stenting
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2016

Study Of The Blood Thinner, Apixaban, For Patients Who Have An Abnormal Heart Rhythm (Atrial Fibrillation) And Expected To Have Treatment To Put Them Back Into A Normal Heart Rhythm (Cardioversion)

Condition:   Atrial Fibrillation
Interventions:   Drug: Apixaban;   Drug: Parenteral heparin and/or oral Vitamin K antagonist
Sponsors:   Pfizer;   Bristol-Myers Squibb
Active, not recruiting - verified September 2016

Brain Biomarkers of Response to Treatment for Apraxia of Speech

Conditions:   Aphasia;   Stroke
Intervention:   Behavioral: Speech Production Treatment
Sponsor:   VA Office of Research and Development
Recruiting - verified September 2016

Accuracy of Pulse Pressure Variation and of Pleth Variability Index to Predict the Response to a Fluid Challenge

Condition:   Fluid Responsiveness
Intervention:   Device: - Nexfin (Pulse Pressure Variation) - Radical 7 (Pleth Variability Index) - CardioQ (stroke volume)
Sponsor:   Hopital Foch
Completed - verified September 2016

Impact of tDCS on Locomotion and Equilibrium in Hemiplegic Patients

Condition:   Gait Disorders
Intervention:   Device: anodal tDCS and sham tDCS stimulations
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting - verified September 2016

Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency

Conditions:   Metabolic Disease;   Seizures
Interventions:   Drug: SGS-742;   Drug: Placebo
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2016

Pilot Trial of Botulinum Toxin and Occupational Therapy for Writer's Cramp

Condition:   Dystonia
Interventions:   Drug: BoNT Injections;   Procedure: Occupational Therapy
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified September 2016

Development of Walk Assist Device to Improve Community Ambulation

Condition:   Stroke
Interventions:   Device: The Stride Management Assist (SMA) System;   Other: Impairment based therapy
Sponsors:   Rehabilitation Institute of Chicago;   Honda
Active, not recruiting - verified September 2016

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified September 2016

The Alberta Vascular Risk Reduction Community Pharmacy Project: RxEACH

Conditions:   Diabetes;   Chronic Kidney Disease;   Established Atherosclerotic Vascular Disease;   Framingham Risk Score >20%
Intervention:   Other: Advanced Care
Sponsors:   University of Alberta;   Alberta Health & Wellness;   Alberta Health Services;   Merck Frosst Canada Ltd.
Completed - verified September 2016

AMPLATZER Cardiac Plug (ACP) Latin American Post Market Observational

Conditions:   Atrial Fibrillation;   Left Atrial Appendage;   Stroke
Intervention:   Device: Amplatzer Cardiac Plug
Sponsor:   St. Jude Medical
Withdrawn - verified September 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Germany)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsor:   Bayer
Recruiting - verified September 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxoban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsor:   Bayer
Recruiting - verified September 2016

GLORIA-AF Registry Program (Phase II/III)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified September 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)

Condition:   Pulmonary Embolism
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Warfarin
Sponsor:   Bayer
Recruiting - verified September 2016

Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Placebo;   Drug: Linagliptin
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting - verified September 2016

Long-Term rIsk, Clinical manaGement and Healthcare Resource Utilization of Stable CAD in Post MI Patients

Condition:   Stable Coronary Artery Disease (CAD), Myocardial Infarction
Intervention:  
Sponsor:   AstraZeneca
Active, not recruiting - verified September 2016

Vein of Marshall Ethanol Infusion for Persistent Atrial Fibrillation

Conditions:   Ventricular Tachycardia;   Atrial Fibrillation
Interventions:   Drug: Ethanol;   Procedure: Ablation
Sponsors:   Miguel X. Valderrabano, MD;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI);   The Methodist Hospital System
Recruiting - verified September 2016

Detecting and Addressing Preclinical Disability

Conditions:   Back Pain;   Coronary Artery Disease;   Chronic Obstructive Pulmonary Disease;   Diabetes;   Hypertension;   Multiple Sclerosis;   Osteoporosis;   Osteoarthritis;   Rheumatoid Arthritis;   Stroke
Intervention:   Other: Tailored advice from a physiotherapist and/or an occupational therapist through the myOSCAR patient portal
Sponsors:   McMaster University;   Labarge Optimal Aging Initiative (Private Donor)
Active, not recruiting - verified September 2016

A Study Exploring Two Strategies of Rivaroxaban (JNJ39039039; BAY-59-7939) and One of Oral Vitamin K Antagonist in Patients With Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention

Conditions:   Atrial Fibrillation;   Percutaneous Coronary Intervention
Interventions:   Drug: rivaroxaban 2.5 mg;   Drug: rivaroxaban 15 mg;   Drug: rivaroxaban 10 mg;   Drug: aspirin (ASA);   Drug: vitamin K antagonist (VKA);   Drug: clopidogrel;   Drug: prasugrel;   Drug: ticagrelor
Sponsors:   Janssen Scientific Affairs, LLC;   Bayer
Completed - verified September 2016

A New Multi-parameter Neuromonitoring System to Save Patients' Lives in Stroke and Brain Injury

Conditions:   Subarachnoid Hemorrhage;   Optical Imaging
Intervention:   Device: NeMo Patch and NeMo Probe
Sponsors:   NeMoDevices AG;   Medical University of Graz;   University of Zurich
Recruiting - verified September 2016

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention &Amp; Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute
Recruiting - verified September 2016

AMPLATZER Cardiac Plug (ACP) Registry-Long Term Follow-up Protocol

Conditions:   Atrial Fibrillation;   Left Atrial Appendage;   Stroke
Intervention:   Device: Amplatzer Cardiac Plug
Sponsor:   St. Jude Medical
Completed - verified September 2016

SPARK: Safety Study of Pradaxa in Atrial Fibrillation Patients by Regulatory Requirement of Korea

Condition:   Atrial Fibrillation
Intervention:   Drug: Pradaxa (Dabigatran etexilate mesilate)
Sponsor:   Boehringer Ingelheim
Recruiting - verified September 2016

Ponatinib as Second Line Therapy for Patients With Chronic Myeloid Leukemia in Chronic Phase Resistant or Intolerant to Imatinib, Dasatinib or Nilotinib

Condition:   Leukemia
Intervention:   Drug: Ponatinib
Sponsors:   M.D. Anderson Cancer Center;   Ariad Pharmaceuticals
Active, not recruiting - verified September 2016

Multicenter Trial to Evaluate the Effect of Dapagliflozin on the Incidence of Cardiovascular Events

Conditions:   Diabetes Mellitus, Non-Insulin-Dependent;   High Risk for Cardiovascular Event
Interventions:   Drug: Dapagliflozin 10 mg;   Drug: Placebo tablet
Sponsors:   AstraZeneca;   Bristol-Myers Squibb;   The TIMI Study Group;   Hadassah Medical Organization
Active, not recruiting - verified September 2016

Examining How Motor Rehabilitation Promotes Brain Reorganization Following Stroke, an MRI Study

Conditions:   Stroke;   Hemiparesis
Intervention:   Behavioral: CI therapy
Sponsor:   Lynne Gauthier , PhD
Active, not recruiting - verified September 2016

The CHAPTER II Study - Congenital Heart Adolescents Participating in Transition Evaluation Research

Condition:   Congenital Heart Disease
Interventions:   Behavioral: Educational;   Behavioral: Self management
Sponsors:   University of Alberta;   Heart and Stroke Foundation of Canada
Active, not recruiting - verified September 2016

STOP-AUST: The Spot Sign and Tranexamic Acid On Preventing ICH Growth - AUStralasia Trial

Conditions:   Intracerebral Haemorrhage;   Stroke
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsor:   Neuroscience Trials Australia
Recruiting - verified September 2016

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab;   Drug: Placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified September 2016

Patient-Partner Stress Management Effects on Chronic Fatigue Syndrome Symptoms and Neuroimmune Process

Condition:   Chronic Fatigue Syndrome
Interventions:   Behavioral: Patient-Partner Videotelephone-delivered Health Information (PP-T-HI);   Behavioral: Patient-Partner Videotelephone-delivered Cognitive Behavioral Stress Management intervention (PP-T-CBSM)
Sponsors:   University of Miami;   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified September 2016

Phase II Front-line Ponatinib in Adult Philadelphia+/BCR-ABL+ Acute Lymphoblastic Leukemia.

Conditions:   Philadelphia Positive;   BCR-ABL Positive;   Acute Lymphoblastic Leukemia
Intervention:   Drug: Ponatinib
Sponsor:   Gruppo Italiano Malattie EMatologiche dell'Adulto
Recruiting - verified September 2016

BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity

Conditions:   Pediatrics;   Muscle Spasticity;   Cerebral Palsy;   Stroke
Intervention:   Biological: botulinum toxin Type A
Sponsor:   Allergan
Recruiting - verified September 2016

BOTOX® Treatment in Pediatric Upper Limb Spasticity

Conditions:   Pediatrics;   Muscle Spasticity;   Cerebral Palsy;   Stroke
Interventions:   Biological: botulinum toxin Type A;   Biological: botulinum toxin Type A;   Drug: Normal Saline (Placebo)
Sponsor:   Allergan
Recruiting - verified September 2016

EXTEND (International): Extending the Time for Thrombolysis in Emergency Neurological Deficits (International)

Condition:   Stroke
Interventions:   Drug: Tissue Plasminogen Activator (Alteplase);   Drug: Placebo
Sponsors:   Neuroscience Trials Australia;   China Medical University Hospital
Recruiting - verified September 2016

The Childhood and Adolescent Migraine Prevention Study

Conditions:   Migraine;   Migraine Disorders;   Headache
Interventions:   Drug: Amitriptyline;   Drug: Topiramate;   Drug: Placebo
Sponsors:   Children's Hospital Medical Center, Cincinnati;   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified September 2016

Step Monitoring to Improve ARTERial Health

Conditions:   Type 2 Diabetes;   Hypertension
Interventions:   Behavioral: Step count prescription;   Behavioral: Usual care
Sponsors:   McGill University Health Center;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting - verified September 2016

GLORIA-AF Registry Program - Second and Third Phases

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified September 2016

Sustained Treatment of Paroxysmal Atrial Fibrillation Post-Approval Study (STOP AF PAS)

Condition:   Paroxysmal Atrial Fibrillation (PAF)
Intervention:   Device: Medtronic Arctic Front® Cardiac CryoAblation System
Sponsor:   Medtronic Atrial Fibrillation Solutions
Active, not recruiting - verified September 2016

Bazedoxifene Post Approval Safety Study (PASS) in the European Union (EU)

Condition:   Osteoporosis, Postmenopausal
Interventions:   Drug: Bazedoxifene;   Drug: Bisphosphonate;   Drug: Raloxifene
Sponsor:   Pfizer
Active, not recruiting - verified September 2016

Clinical Randomisation of an Antifibrinolytic in Significant Head Injury

Condition:   Traumatic Brain Injury
Intervention:   Drug: Tranexamic Acid
Sponsor:   London School of Hygiene and Tropical Medicine
Recruiting - verified September 2016

Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial

Conditions:   Acute Ischemic Stroke;   Diabetes;   Hyperglycemia
Interventions:   Drug: IV insulin to maintain target glucose concentration of 80-130 mg/dL;   Drug: Standard Care control - sliding scale insulin to keep glucose less than 180 mg/dL
Sponsors:   University of Virginia;   Neurological Emergencies Treatment Trials Network (NETT);   Medical University of South Carolina;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2016

Patients Undergoing Major Cancer Surgery: Incidence and Predictive Value for Postoperative Cardiac Events

Condition:   High Risk for Postoperative Cardiovascular Events
Intervention:   Other: endothelial function testing
Sponsor:   Memorial Sloan Kettering Cancer Center
Active, not recruiting - verified September 2016

Systolic Blood Pressure Intervention Trial

Condition:   Hypertension
Interventions:   Other: Intensive control of SBP;   Other: Standard BP arm
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   National Institute on Aging (NIA);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   National Institute of Neurological Disorders and Stroke (NINDS);   Wake Forest Baptist Health
Active, not recruiting - verified September 2016

Grain Exercise Trial - Whole Grain Versus no Grain With or Without Physiotherapy-promoted Exercise for Waist Loss

Conditions:   Abdominal Obesity;   Cardiovascular Diseases;   Diabetes Type 2;   Hypertension;   Overweight
Interventions:   Behavioral: Diet A;   Behavioral: Diet B;   Behavioral: Physiotherapy
Sponsors:   Lund University;   Region Skane
Completed - verified September 2016

Study of Subthalamic Brain Stimulation in Parkinson Disease (PD)

Condition:   Parkinson Disease
Intervention:   Device: Implantable pulse generator (deep brain stimulator)
Sponsors:   University of Alabama at Birmingham;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified September 2016

Electrical Stimulation for the Treatment of Post-Stroke Shoulder Pain

Condition:   Shoulder Pain
Intervention:   Device: The SPR System
Sponsor:   NDI Medical, LLC
Active, not recruiting - verified September 2016

Risk of Cardiovascular Events in Patients With Type 2 Diabetes Initiating Oral Antidiabetic Treatments

Condition:   Diabetes Mellitus, Type 2
Intervention:  
Sponsors:   AstraZeneca;   Bristol-Myers Squibb;   University of Pennsylvania
Completed - verified September 2016

Post-authorization Safety Study of Etoricoxib and Other Anti-inflammatory Therapies in European Patients With Ankylosing Spondylitis (MK-0663-163)

Condition:   Ankylosing Spondylitis
Intervention:  
Sponsor:   Merck Sharp & Dohme Corp.
Active, not recruiting - verified September 2016

BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

Conditions:   Tetraplegia;   Spinal Cord Injuries;   Amyotrophic Lateral Sclerosis;   Brain Stem Infarctions;   Locked in Syndrome;   Muscular Dystrophy
Intervention:   Device: Placement of the BrainGate2 sensor(s) into the motor-related cortex
Sponsors:   Leigh R. Hochberg, MD, PhD.;   National Center for Medical Rehabilitation Research (NCMRR);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute on Deafness and Other Communication Disorders (NIDCD);   VA Office of Research and Development;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2016

Neuroregeneration Enhanced by Transcranial Direct Current Stimulation (TDCS) in Stroke

Condition:   Stroke
Intervention:   Device: DC-Stimulator to apply tDCS or Sham tDCS
Sponsor:   Universitätsklinikum Hamburg-Eppendorf
Recruiting - verified September 2016

Extending the Time for Thrombolysis in Emergency Neurological Deficits

Condition:   Stroke
Interventions:   Drug: Tissue Plasminogen Activator (Alteplase);   Drug: Placebo
Sponsors:   Neuroscience Trials Australia;   Commonwealth Scientific and Industrial Research Organisation, Australia;   Brain Research Institute;   University of Melbourne;   Melbourne Health
Recruiting - verified September 2016

The Effects of Exenatide (Byetta ) on Energy Expenditure and Weight Loss in Nondiabetic Obese Subjects

Conditions:   Weight Loss;   Obesity
Interventions:   Drug: Byetta (exenatide);   Behavioral: Weight loss;   Other: Metabolic Chamber;   Drug: Placebo
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed - verified November 2015

Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia

Conditions:   Spasmodic Dysphonia;   Focal Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified September 2016

Neurobiology of Psychogenic Movement Disorder and Non-Epileptic Seizures

Conditions:   Psycogenic Movement Disorders;   Non-epileptic Seizures
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2016

Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies

Conditions:   Aphasia;   Nonfluent Aphasia;   Stroke
Intervention:  
Sponsors:   VA Office of Research and Development;   Boston University
Active, not recruiting - verified September 2016

Model System for Transient Forearm Blood Vessel Dysfunction

Conditions:   Limb Ischemia;   Ischemic Preconditioning
Interventions:   Procedure: Limb Ischemia;   Drug: Acetylcholine
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified February 2009

Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study

Conditions:   Stroke;   Diabetes Mellitus;   Heart Disease;   Cancer
Intervention:  
Sponsors:   National Cancer Institute (NCI);   National Institute for Health and Welfare, Finland
Completed - verified September 2016

Comparison of TransMID vs Standard Treatment of Cancerous Brain Tumors

Condition:   Glioblastoma
Intervention:   Drug: TransMID
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified September 2016

Levetiracetam Treatment of L-dopa Induced Dyskinesias

Conditions:   Dyskinesias;   Parkinson Disease
Intervention:   Drug: Intravenous Levodopa
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified October 2005

Pelvic Pain in Women With Endometriosis

Conditions:   Endometriosis;   Pelvic Pain;   Healthy;   Tubal Ligation
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified September 2016

Bone Response to Enzyme Replacement in Gaucher's Disease

Condition:   Gaucher's Disease
Intervention:   Drug: CEREDASE™
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified September 2016