Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Chronicity Dependence of a Balance Training in Adults Post-stroke

Condition:   Stroke, Postural Balance, Virtual Rehabilitation
Intervention:   Other: balance virtual rehabilitation
Sponsors:   Hospitales Nisa;   Universidad Politécnica de Valencia
Completed - verified February 2016

Safety and Efficacy Study of a Protease Activated Receptor-4 Antagonist Being Tested to Reduce the Chances of Having Additional Strokes or "Mini Strokes"

Condition:   Thrombosis
Interventions:   Drug: BMS-986141;   Drug: Aspirin;   Other: Placebo
Sponsor:   Bristol-Myers Squibb
Not yet recruiting - verified January 2016

The Fluid Therapy Strategy of the Non-dehydrated Patients With Acute Ischemic Stroke.

Conditions:   Stroke;   Dehydration
Intervention:   Dietary Supplement: water
Sponsor:   Chang Gung Memorial Hospital
Recruiting - verified January 2016

Effects of Transcranial Direct Current Stimulation Plus Language Therapy for Naming in Subacute Left Hemisphere Stroke

Condition:   Stroke
Interventions:   Device: A-tDCS (1 mA);   Behavioral: SALT;   Device: Sham
Sponsors:   Johns Hopkins University;   University of South Carolina
Not yet recruiting - verified January 2016

Which Parameters of Short-term Blood Pressure Variability Best Predict Early Outcomes in Acute Ischemic Stroke

Condition:   Stroke
Intervention:  
Sponsor:   Dongguan People's Hospital
Recruiting - verified February 2016

Sensory Stimulation to Enhance Hand Function Post Stroke

Condition:   Stroke
Interventions:   Other: Vibration;   Other: Placebo (for vibration);   Behavioral: therapy
Sponsors:   Medical University of South Carolina;   National Institute of General Medical Sciences (NIGMS)
Recruiting - verified February 2016

Safety and Efficacy of Post Ablation Apixaban Use for Reduction of the Risk of Cerebrovascular Events in Patients Undergoing Ventricular Tachycardia Radiofrequency Catheter Ablation

Condition:   Ventricular Tachycardia
Interventions:   Drug: Apixaban;   Drug: Aspirin
Sponsors:   Dhanunjaya Lakkireddy, MD, FACC;   Bristol-Myers Squibb
Not yet recruiting - verified January 2016

The Influence of Circadian and Long-term Blood Pressure Variation on the Recurrent Stroke

Condition:   Stroke
Intervention:  
Sponsor:   Zhu Shi
Recruiting - verified January 2016

MR-based Collateral Imaging to Predict Response to Endovascular Treatment of Stroke (FAST-COLL Study)

Condition:   Stroke
Intervention:   Procedure: Endovascular treatment
Sponsor:   Samsung Medical Center
Recruiting - verified January 2016

Quality Improvement and Practice Based Research in Neurology Using the EMR

Conditions:   Brain Tumors;   Epilepsy;   Migraine;   Mild Cognitive Impairment;   Concussion;   Multiple Sclerosis;   Neuropathy;   Parkinson's;   Restless Legs Syndrome;   Stroke
Intervention:   Drug: Listed for each disorder below, up to three drugs per disorder (too many characters to list in this field; see Intervention Description)
Sponsor:   NorthShore University HealthSystem Research Institute
Not yet recruiting - verified January 2016

Fractional FLow Reserve And IVUS for Clinical OUtcomes in Patients With InteRmediate Stenosis

Condition:   Stable Angina
Intervention:   Device: Drug-eluting stent
Sponsors:   Seoul National University Hospital;   Ajou University School of Medicine;   Keimyung University Dongsan Medical Center;   Inje University
Not yet recruiting - verified February 2016

Early Intensive Physical Therapy in Subarachnoid Hemorrhage

Condition:   Subarachnoid Hemorrhage
Intervention:   Other: Physical Therapy
Sponsor:   University of Colorado, Denver
Not yet recruiting - verified February 2016

Biofeedback to Increase Propulsion During Walking After Stroke

Condition:   Stroke
Interventions:   Procedure: Gait Training with Biofeedback;   Procedure: Gait Training with Verbal Feedback
Sponsor:   VA Office of Research and Development
Not yet recruiting - verified January 2016

Cortical Reorganization Models for Motor Areas and Inter-hemispheric Equilibrium Post-stroke: a Pilot Study

Condition:   Stroke
Interventions:   Procedure: Physiotherapy;   Procedure: Occupational therapy;   Procedure: Functional near-infrared spectroscopy
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Not yet recruiting - verified February 2016

The Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis

Condition:   Aortic Stenosis
Interventions:   Procedure: Surgical aortic valve replacement (SAVR);   Device: Transcatheter Aortic Valve Replacement (TAVR)
Sponsor:   Edwards Lifesciences
Not yet recruiting - verified February 2016

Influence of a Multi-parametric Optimization Strategy for General Anesthesia on Postoperative Morbidity and Mortality

Conditions:   Coronary; Ischemic;   Arrhythmias, Cardiac;   Heart Failure;   Peripheral Vascular Diseases;   Dementia;   Stroke;   Pulmonary Disease, Chronic Obstructive;   Respiratory Insufficiency;   Alcoholism;   Cancer;   Diabetes;   Renal Insufficiency
Interventions:   Procedure: OPTI-AGED;   Procedure: Usual Care
Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
Not yet recruiting - verified January 2016

Comparison of Efficacy and Safety Among Dabigatran, Rivaroxaban, and Apixaban in Non-Valvular Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Drug: Dabigatran etexilate;   Drug: Rivaroxaban;   Drug: Apixaban
Sponsors:   National Cheng-Kung University Hospital;   Tainan Municipal Hospital;   E-DA Hospital;   National Cheng-Kung University Hospital Dou-Liou Branch;   Ministry of Health and Welfare, Taiwan
Not yet recruiting - verified January 2016

Vertebral Artery and Cerebral Hemodynamics After Various Head Positions & Manipulation in Patients With Neck Pain

Conditions:   Vertebral Artery Dissection;   Cerebrovascular Accident;   Stroke
Intervention:   Other: Head positions and spinal manipulation
Sponsors:   Canadian Memorial Chiropractic College;   Canadian Medical Protective Association;   National Chiropractic Mutual Insurance Company (NCMIC)
Not yet recruiting - verified January 2016

Regional and Long Term Outcomes of Acute Kidney Injury in England From 2000 to 2015 - A National Database Study

Condition:   Acute Kidney Injury
Intervention:  
Sponsor:   Derby Hospitals NHS Foundation Trust
Completed - verified February 2016

Low Dose Hydroxyurea for Secondary Stroke Prevention in Children With Sickle Cell Disease in Sub-Saharan Africa

Conditions:   Sickle Cell Disease;   Sickle Cell Anemia;   Stroke
Interventions:   Drug: Moderate Dose Hydroxyurea;   Drug: Low Dose Hydroxyurea
Sponsors:   Vanderbilt University;   Aminu Kano Teaching Hospital;   Murtala Muhammed Specialist Hospital
Not yet recruiting - verified February 2016

Prospective Evaluation of Prognosis of Pci Patients Using Network Data in SHengjing Hospital

Condition:   Coronary Heart Disease
Intervention:   Procedure: PCI
Sponsor:   Shengjing Hospital
Not yet recruiting - verified January 2016

Evaluation of the Roadsaver Stent Used in Conjunction With the Nanoparasol Embolic Protection System for Carotid Artery Stenosis

Condition:   Carotid Artery Stenosis
Interventions:   Device: Roadsaver™ Carotid Artery Stent Device;   Device: Nanoparasol® Embolic Protection System
Sponsor:   Microvention-Terumo, Inc.
Not yet recruiting - verified February 2016

Retrospective Evaluation of Prognosis of Pci Patients Using Network Data in SHengjing Hospital

Condition:   Coronary Heart Disease
Intervention:   Procedure: PCI
Sponsor:   Shengjing Hospital
Recruiting - verified January 2016

Plaque Prolapse Prevention Carotid Artery Stenting (3PCAS) Randomized Controlled Trial

Condition:   Cerebrovascular Disease
Intervention:   Procedure: Carotid stenting procedure by carotid stent implantation
Sponsor:   University of Roma La Sapienza
Recruiting - verified January 2016

The Trinity, Ulster and Department of Agriculture Cohort Study

Conditions:   Cardiovascular Disease;   Osteoporosis;   Alzheimer's Disease;   Hypertension
Intervention:  
Sponsors:   University of Ulster;   University of Dublin, Trinity College;   University College Cork;   University College Dublin
Active, not recruiting - verified January 2016

Knowledge Translation for Patients With Acute Coronary Syndromes

Condition:   Acute Coronary Syndromes
Intervention:   Behavioral: knowledge translation
Sponsors:   Montreal General Hospital;   Sanofi;   Canadian Institutes of Health Research (CIHR);   Fonds de la Recherche en Santé du Québec
Completed - verified January 2016

APIXABAN in the Prevention of Stroke and Systemic Embolism in Patients With Atrial Fibrillation in Real-Life Setting in France SNIIRAM Study

Condition:   Anticoagulation
Interventions:   Drug: VKA;   Drug: Apixaban;   Drug: dabigatran;   Drug: rivaroxaban
Sponsor:   Bristol-Myers Squibb
Active, not recruiting - verified January 2016

Metabolic Effects of Angiotensin-(1-7)

Conditions:   Obesity;   Insulin Resistance;   Hypertension;   Metabolic Cardiovascular Syndrome
Interventions:   Drug: Angiotensin-(1-7);   Drug: Saline
Sponsor:   Vanderbilt University
Recruiting - verified February 2016

Hydroxychloroquine in Acute Coronary Syndrome: Prevention of Recurrent Cardiovascular Events

Conditions:   Myocardial Infarction;   Acute Coronary Syndrome;   Inflammation;   Hydroxychloroquine;   Antirheumatic Agents;   Cardiovascular Diseases;   Angina, Unstable
Interventions:   Drug: Hydroxychloroquine;   Drug: Placebo
Sponsors:   Helsinki University Central Hospital;   Finnish Foundation for Cardiovascular Research;   Orion Corporation, Orion Pharma
Not yet recruiting - verified February 2016

Length of Stay in NVAF Patients Hospitalized and Initiated With Dabigatran or Warfarin in Japan

Condition:   Atrial Fibrillation
Interventions:   Drug: Dabigatran;   Drug: Wafrarin
Sponsor:   Boehringer Ingelheim
Not yet recruiting - verified January 2016

HBOT Global Functioning After Stroke

Condition:   Stroke
Interventions:   Other: Hyperbaric Oxygen Therapy (HBOT) and Exercise Program;   Other: Exercise Program;   Device: Hyperbaric Multiplace Chamber
Sponsor:   University Health Network, Toronto
Recruiting - verified January 2016

GLP-1 and Hyperoxia for Organ Protection in Heart Surgery

Conditions:   Coronary Disease;   Shock, Cardiogenic;   Renal Failure;   Stroke;   Brain Injury;   Aortic Valve Disease
Interventions:   Drug: Byetta (Lilly, Exenatide);   Drug: Conoxia (AGA, oxygen);   Drug: 20% Human Albumin
Sponsor:   Rigshospitalet, Denmark
Not yet recruiting - verified February 2016

Consolidating Tools for Outcomes in Resuscitation

Conditions:   Cardiac Arrest;   Cardiopulmonary Resuscitation;   Simulation;   Education
Interventions:   Device: Knowledge-based cognitive aid;   Device: Cognitive aids with roles defined (CARD);   Device: Integrated cognitive aids
Sponsors:   Ottawa Hospital Research Institute;   The Physicians' Services Incorporated Foundation;   University of Ottawa;   Children's Hospital of Eastern Ontario;   The Hospital for Sick Children;   Montreal Children's Hospital of the MUHC;   Alberta Children's Hospital;   Stollery Children's Hospital
Not yet recruiting - verified February 2016

Communicating Multiple Disease Risks

Condition:   Healthy
Interventions:   Behavioral: Cognitive interview;   Other: Survey
Sponsor:   Washington University School of Medicine
Recruiting - verified February 2016

Reliability of the Melbourne Assessment

Conditions:   Cerebral Palsy;   Stroke;   Traumatic Brain Injury;   Meningomyelocele;   Central Nervous System Diseases
Intervention:  
Sponsor:   University Children's Hospital, Zurich
Recruiting - verified September 2015

Open-Label and Single-Arm Study of MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adults

Condition:   Sialorrhea
Intervention:   Drug: MYOBLOC
Sponsor:   US WorldMeds LLC
Recruiting - verified January 2016

Randomized Trial of COBRA PzF Stenting to Reduce Duration of Triple Therapy

Conditions:   Angina, Stable;   Angina, Unstable;   Anticoagulants
Interventions:   Device: COBRA PzF;   Device: DES
Sponsor:   CeloNova BioSciences, Inc.
Recruiting - verified February 2016

Burden of Illness in Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Drug: Standard of care in AF in Denmark
Sponsor:   Bayer
Completed - verified February 2016

The Relationship Between HHcy and Contrast-induced Nephropathy in Hypertensive Patients After Coronary Artery Diagnosis and Treatment

Conditions:   Homocysteine;   Coronary Disease;   Angioplasty,Balloon,Coronary;   Contrast Media;   Nephropathy;   Hypertension
Interventions:   Drug: Enalapril Maleate Tablets(as the program-based antihypertension);   Drug: Enalapril Maleate and Folic Acid tablets(as the program-based antihypertension);   Drug: Placebo
Sponsor:   Fuling Central Hospital of Chongqing City
Recruiting - verified February 2016

Effects of Mental Practice for Mobility and Gait Function in Post-stroke Hemiparesis

Conditions:   Stroke;   Hemiparesis
Interventions:   Other: Mental practice;   Other: Physiotherapy;   Other: Cognitive training and Relaxation
Sponsor:   Federal University of Juiz de Fora
Recruiting - verified February 2016

Novel Treatment For Pusher Syndrome Using Physical Therapy

Condition:   Pusher Syndrome
Interventions:   Other: Novel physical therapy;   Other: Standard physical therapy
Sponsor:   Loma Linda University
Enrolling by invitation - verified January 2016

Optilene® Suture for Coronary Artery Bypass Graft Surgery

Conditions:   Coronary Heart Disease;   Multi Vessel Coronary Artery Disease
Intervention:   Procedure: Coronary Artery Bypass Graft surgery
Sponsors:   Aesculap AG;   B.Braun Surgical SA
Recruiting - verified January 2016

Phase IV O2 Consumption Study in COPD Patients

Condition:   Chronic Obstructive Pulmonary Disease (COPD)
Interventions:   Drug: Budesonide 160 mcg and formoterol fumarate dehydrate 4.5 mcg Inhalation aerosol;   Drug: Matching Placebo pMDI 160/4.5 μg
Sponsor:   AstraZeneca
Recruiting - verified January 2016

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Recruiting - verified February 2016

Interactive Exoskeleton Robot for Walking - Knee Joint

Condition:   Stroke
Intervention:   Device: Knee robot
Sponsors:   Chinese University of Hong Kong;   The Hong Kong Polytechnic University
Recruiting - verified February 2016

Forced Aerobic Exercise for Stroke Rehabilitation

Condition:   Stroke
Interventions:   Behavioral: Forced Exercise & Upper Extremity Repetitive Task Practice;   Behavioral: Voluntary Exercise & Upper Extremity Repetitive Task Practice;   Behavioral: Stroke Education & Upper Extremity Repetitive Task Practice
Sponsors:   The Cleveland Clinic;   American Heart Association
Recruiting - verified January 2016

Speed of Processing Training in Traumatic Brain Injury

Conditions:   Traumatic Brain Injury;   Vascular Accident, Brain
Interventions:   Other: Brain Fitness Program;   Other: Weekly Telephone Contact
Sponsor:   New York University School of Medicine
Recruiting - verified January 2016

Clinical Performance and Safety Assessment of the Paladin®

Condition:   Carotid Artery Stenosis
Intervention:   Device: Paladin® Embolic Protection System
Sponsor:   Contego Medical, LLC
Recruiting - verified February 2016

Southwest Health Extension Partnership to Enhance Research Dissemination

Condition:   Cardiovascular Diseases
Interventions:   Other: Enhanced practice transformation support;   Other: Standard practice transformation support
Sponsors:   University of Colorado, Denver;   University of New Mexico
Recruiting - verified February 2016

Decision Aids in Cerebral Aneurysm Treatment

Condition:   Cerebral Aneurysm
Interventions:   Behavioral: Option grid for cerebral aneurysm treatment;   Behavioral: Control
Sponsor:   Dartmouth-Hitchcock Medical Center
Withdrawn - verified February 2016

Prevention of Syncope Trial 6 - Atomoxetine in Vasovagal Syncope

Condition:   Vasovagal Syncope
Interventions:   Drug: Atomoxetine;   Drug: Placebo
Sponsors:   University of Calgary;   Cardiac Arrhythmia Network of Canada
Recruiting - verified January 2016

The Effects of CPAP Withdrawal on Cerebral Vascular Reactivity and Brain Oxygenation in OSA

Condition:   Sleep Apnea, Obstructive
Intervention:   Device: Continuous positive airway pressure device
Sponsor:   University of Zurich
Recruiting - verified February 2016

High-risk Patients in Cardiac Surgery Procedures: HiriSCORE

Condition:   C.Surgical Procedure; Cardiac
Intervention:  
Sponsors:   University of Sao Paulo General Hospital;   InCor Heart Institute;   Cardiology Institute of the Distrito Federal, Brazil;   Clinical Hospital Samuel Libânio of Pouso Alegre, Brazil;   Beneficência Portuguesa of São Paulo, Brazil;   Hospital Clínico Universitario de Valladolid;   National Institute of Cardiology, Laranjeiras, Brazil;   Russian Cardiology Research and Production Center, Russian;   La Princesa University Hospital Madrid, Spain;   TotalCor Hospital, Brazil;   Royal Adelaide Hospital;   Santa Casa de Misericórdia of Marília, Brazil;   Hospital de Base
Active, not recruiting - verified June 2015

Acupuncture for Ischemic Post-stroke Depression

Condition:   Post-stroke Depression
Interventions:   Device: acupuncture;   Drug: placebo;   Device: sham-acupoint acupuncture;   Drug: Fluoxetine
Sponsors:   Menghan Li;   State Administration of Traditional Chinese Medicine of the People's Republic of China
Not yet recruiting - verified February 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsor:   Bayer
Recruiting - verified February 2016

Interactive Exoskeleton Robot for Walking - Ankle Joint

Condition:   Stroke
Interventions:   Device: Ankle Robot with Power Assistance;   Device: Sham
Sponsors:   Chinese University of Hong Kong;   Innovation and Technology Commission, Hong Kong
Recruiting - verified February 2016

Effects of Training Caregivers on the Outcomes of Stroke Survivors and Caregivers in Zimbabwe

Condition:   Stroke
Intervention:   Other: Caregiver training
Sponsors:   University of Zimbabwe;   National Institutes of Health (NIH)
Recruiting - verified February 2016

Effect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus
Interventions:   Biological: Albiglutide 30 mg;   Biological: Albiglutide 50 mg;   Biological: Albiglutide matching placebo
Sponsors:   GlaxoSmithKline;   Duke Clinical Research Institute
Recruiting - verified January 2016

A Long-Term Extension Study of RP103-MITO-001 to Assess RP103 in Children With Inherited Mitochondrial Disease

Condition:   Mitochondrial Diseases
Intervention:   Drug: Cysteamine Bitartrate Delayed-release Capsules
Sponsor:   Raptor Pharmaceuticals Inc.
Enrolling by invitation - verified June 2015

Safety and Performance Study of the Edwards CENTERA-EU Self-Expanding Transcatheter Heart Valve

Condition:   Aortic Valve Disease
Intervention:   Device: Edwards CENTERA Self-Expanding Transcatheter Heart Valve
Sponsors:   Edwards Lifesciences;   Medstar Research Institute;   European Cardiovascular Research Center;   University of British Columbia
Recruiting - verified January 2016

Fall Prevention and Locomotion Recovery in Post-stroke Patients: A Multimodal Training

Condition:   Stroke
Interventions:   Device: Cycling;   Device: Balance;   Other: Standard physical therapy
Sponsors:   Fondazione Salvatore Maugeri;   Politecnico di Milano
Recruiting - verified February 2016

Rehabilitation Training After Stroke

Condition:   Stroke
Intervention:   Other: Rehabilitation
Sponsors:   NIHR Exeter Clinical Research Facility;   The Stroke Association, United Kingdom;   University of Exeter
Active, not recruiting - verified February 2016

Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension

Condition:   Hypertension
Intervention:   Drug: Trimethaphan
Sponsor:   Vanderbilt University
Recruiting - verified February 2016

Home-based Respiratory Training After Stroke

Condition:   Stroke
Interventions:   Other: Respiratory training;   Other: Control
Sponsor:   Federal University of Minas Gerais
Recruiting - verified February 2016

Neuroprotection in Patients Undergoing Aortic Valve Replacement

Conditions:   Aortic Stenosis;   Brain Infarction;   Cerebrovascular Accident;   Stroke
Interventions:   Device: Embol-X Embolic Protection Device;   Device: CardioGard Cannula
Sponsors:   Icahn School of Medicine at Mount Sinai;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified January 2016

Informal Caregivers ANSWERS

Conditions:   Stroke;   Traumatic Rain Injury
Interventions:   Behavioral: ANSWERS - Acquiring New Skills While Enhancing Remaining Strengths;   Other: Control
Sponsor:   VA Office of Research and Development
Recruiting - verified February 2016

Pipeline™ Flex Embolization Device With Shield Technology™ Clinical Study

Condition:   Aneurysm
Intervention:  
Sponsor:   Medtronic Neurovascular Clinical Affairs
Active, not recruiting - verified January 2016

Valiant Mona LSA Feasibility Study

Condition:   Aortic Aneurysm, Thoracic
Intervention:   Device: Valiant Mona LSA Thoracic Stent Graft System
Sponsor:   Medtronic Endovascular
Recruiting - verified January 2016

Non Invasive Cardiac Output Monitoring to Guide Goal Directed Fluid Therapy in High Risk Patients Undergoing Urgent Surgical Repair of Proximal Femoral Fractures

Condition:   Hip Fractures
Interventions:   Other: Fluid optimisation;   Drug: Optimisation of blood pressure;   Device: Application of clearsight monitor
Sponsor:   York Teaching Hospitals NHS Foundation Trust
Recruiting - verified January 2016

Uninterrupted Dabigatran Etexilate in Comparison to Uninterrupted Warfarin in Pulmonary Vein Ablation (RE-CIRCUIT)

Condition:   Atrial Fibrillation
Interventions:   Drug: Warfarin;   Drug: Dabigatran Etexilate 150mg
Sponsor:   Boehringer Ingelheim
Recruiting - verified January 2016

Effects of Home-based vs. Clinic-based Rehabilitation on Sensorimotor, Cognition, Daily Function, and Participation

Condition:   Chronic Stroke
Intervention:   Behavioral: bilateral training with and without mirror feedback
Sponsor:   Chang Gung Memorial Hospital
Recruiting - verified December 2015

Resistive Training Combined With Nutritional Therapy After Stroke

Condition:   Stroke
Interventions:   Other: Protein;   Other: Placebo
Sponsors:   VA Office of Research and Development;   Baltimore VA Medical Center
Recruiting - verified February 2016

Short Message Service (SMS) Reminders for Stroke Secondary Preventative Medications

Conditions:   Stroke;   Ischemic Attack, Transient
Intervention:   Other: SMS reminder
Sponsors:   NHS Greater Glasgow and Clyde;   University of Glasgow
Completed - verified January 2016

Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)

Condition:   Stroke
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin (Acetylsalicylic acid, BAY1019036);   Other: Rivaroxaban-Placebo;   Other: Aspirin-Placebo
Sponsors:   Bayer;   Janssen, LP;   Hamilton Health Sciences Cooperation, Population Health Research Institute
Recruiting - verified February 2016

Effects of a Self-Management Group-Intervention on Participation in Post-Stroke Patients.

Condition:   Stroke
Interventions:   Behavioral: Self-Management group-intervention;   Behavioral: Standard Care
Sponsors:   Uzi Milman;   University of Haifa
Not yet recruiting - verified January 2016

Hospital Processes Reengineering of Intravenous Thrombolysis in Acute Ischemic Stroke in China

Conditions:   Ischemic Stroke;   Adverse Effect of Thrombolytic Drugs, Sequela
Interventions:   Behavioral: Advance hospital notification by EMS;   Behavioral: stroke team notification;   Behavioral: key performance indicators feedback form;   Behavioral: standard informed consent procedures;   Behavioral: performance of thrombolysis at CT-room
Sponsor:   First Affiliated Hospital of Jinan University
Completed - verified February 2016

Study of Ticagrelor Versus Aspirin Treatment in Patients With Myocardial Injury Post Major Non-cardiac Surgery

Condition:   Myocardial Injury
Interventions:   Drug: ticagrelor;   Drug: aspirin
Sponsors:   The Cleveland Clinic;   AstraZeneca
Recruiting - verified January 2016

Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System

Condition:   Mitral Valve Regurgitation
Intervention:   Device: Mitral valve replacement
Sponsor:   Neovasc Inc.
Recruiting - verified January 2016

Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability

Conditions:   Chronic Troublesome Sialorrhea;   Cerebral Palsy;   Stroke;   Traumatic Brain Injury;   Intellectual Disability
Interventions:   Drug: IncobotulinumtoxinA;   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Recruiting - verified January 2016

Effects of Proximal and Distal Robot-assisted Therapy Combined With Functional Training

Condition:   Stroke
Interventions:   Device: proximal robot-assisted therapy;   Device: distal robot-assisted therapy;   Behavioral: individualized intensive therapy
Sponsor:   Chang Gung Memorial Hospital
Recruiting - verified September 2015

Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

Conditions:   Stroke;   Secondary Prevention
Interventions:   Drug: optional ASA as comedication;   Drug: placebo to ASA;   Drug: placebo to optional ASA as comedication;   Drug: placebo to dabigatran etexilate;   Drug: ASA 100 mg;   Drug: dabigatran etexilate
Sponsor:   Boehringer Ingelheim
Recruiting - verified January 2016

Peripheral Arterial Insufficiency Associated With HIV/AIDS

Conditions:   Arterial Insufficiency;   Acquired Immunodeficiency Syndrome;   HIV
Intervention:   Procedure: Ankle-Brachial index
Sponsor:   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Completed - verified January 2016

Feasibility Controlled Trial of Tibial Nerve Stimulation for Stroke Related Urinary Incontinence

Conditions:   Stroke;   Urinary Incontinence
Interventions:   Device: NeuroTrac continence stimulators;   Device: NeuroTrac continence stimulators
Sponsors:   Glasgow Caledonian University;   The Stroke Association, United Kingdom;   University of Central Lancashire;   Nursing, Midwifery & Allied Health Professions Research Unit;   NHS Greater Glasgow and Clyde;   NHS Lanarkshire
Recruiting - verified February 2016

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease, on Dialysis

Condition:   Anemia
Interventions:   Drug: Roxadustat;   Drug: Epoetin alfa
Sponsors:   AstraZeneca;   FibroGen
Recruiting - verified February 2016

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease (CKD), Not on Dialysis.

Condition:   Anemia
Interventions:   Drug: Roxadustat;   Drug: Placebo
Sponsors:   AstraZeneca;   FibroGen
Active, not recruiting - verified February 2016

Remote Preconditioning Over Time To Empower Cerebral Tissue

Conditions:   Ischemic Stroke;   Cerebral Small Vessel Disease;   Cognitive Decline
Intervention:   Device: Ischemic Preconditioning
Sponsors:   University of California, Los Angeles;   American Heart Association
Recruiting - verified February 2016

Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)

Conditions:   Atrial Fibrillation;   Percutaneous Coronary Intervention
Interventions:   Drug: Dabigatran Etexilate 110mg;   Drug: Warfarin 3mg;   Drug: Aspirin;   Drug: Dabigatran Etexilate 150mg;   Drug: Clopidogrel or Ticagrelor;   Drug: Clopidogrel or Ticagrelor;   Drug: Warfarin 5mg;   Drug: Clopidogrel or Ticagrelor;   Drug: Warfarin 1mg
Sponsor:   Boehringer Ingelheim
Recruiting - verified January 2016

Neural Basis of Decision-Making Deficits in Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Uniformed Services University of the Health Sciences
Recruiting - verified January 2016

HEart and BRain Interfaces in Acute Ischemic Stroke

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsors:   Charite University, Berlin, Germany;   Center for Stroke Research Berlin
Recruiting - verified January 2016

OnabotulinumtoxinA Treatment in Adult Patients With Upper Limb Spasticity

Conditions:   Muscle Spasticity;   Stroke
Interventions:   Biological: onabotulinumtoxinA;   Drug: placebo (normal saline)
Sponsor:   Allergan
Terminated - verified January 2016

A Phase 3 Clinical Outcomes Study to Compare the Incidence of Major Adverse Cardiovascular Events in Subjects Presenting With Acute Coronary Syndrome Treated With Losmapimod Compared to Placebo (LATITUDE-TIMI 60)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Losmapimod 7.5 mg twice daily;   Drug: Placebo twice daily
Sponsors:   GlaxoSmithKline;   The TIMI Study Group
Recruiting - verified January 2016

A Blinded Study to Evaluate Effect on Atrial Fibrillation Burden in Patients With Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Interventions:   Drug: BMS-919373;   Drug: Placebo (Matching with BMS-919373)
Sponsor:   Bristol-Myers Squibb
Recruiting - verified January 2016

Intra-aortic Balloon Counterpulsation in Patients Undergoing Cardiac Surgery

Condition:   Postoperative; Dysfunction Following Cardiac Surgery
Intervention:   Device: Intra-aortic balloon pump.
Sponsor:   University of Sao Paulo
Recruiting - verified February 2016

A Self-efficacy Enhancing Stroke Self-management Program for Community-dwelling Stroke Survivors

Condition:   Stroke
Interventions:   Behavioral: Stroke self-management program;   Behavioral: Usual care
Sponsor:   Queensland University of Technology
Active, not recruiting - verified January 2016

Deep Brain Stimulation Therapy in Movement Disorders

Conditions:   Parkinson's Disease;   Movement Disorders;   Deep Brain Stimulation;   Dystonia;   Essential Tremor
Intervention:   Other: Deep Brain Stimulation Management
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2016

Human-Machine System for the H2 Lower Limb Exoskeleton

Conditions:   Stroke;   Hemiparesis
Interventions:   Behavioral: Robot-assisted training with the H2 lower limb powered exoskeleton;   Behavioral: Supervised motor practice
Sponsors:   University of Houston;   The University of Texas Health Science Center, Houston;   TIRR Memorial Hermann
Recruiting - verified January 2016

A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients

Conditions:   Heart Failure;   Respiratory Insufficiency;   Stroke Acute;   Infectious Diseases;   Rheumatic Diseases
Interventions:   Drug: Rivaroxaban, 10 mg;   Drug: Rivaroxaban, 7.5 mg;   Drug: Placebo
Sponsor:   Janssen Research & Development, LLC
Recruiting - verified January 2016

BUN/Cr-based Hydration Therapy to Improve Outcomes for Dehydrated Patients With Acute Ischemic Stroke.

Conditions:   Stroke;   Dehydration
Intervention:   Other: normal saline
Sponsor:   Chang Gung Memorial Hospital
Recruiting - verified January 2016

Combined Bronchodilators in Chronic Obstructive Pulmonary Disease and the Risk of Adverse Cardio-pulmonary Events

Condition:   Pulmonary Disease, Chronic Obstructive
Intervention:  
Sponsor:   Boehringer Ingelheim
Completed - verified January 2016

fMRI Neurofeedback for Motor Rehabilitation

Conditions:   Stroke;   fMRI
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Suspended - verified July 2015

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy;   Device: Carotid stenting
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2016

A Study of the Efficacy and Safety of Activase (Alteplase) in Patients With Mild Stroke (PRISMS)

Condition:   Brain Ischemia
Interventions:   Drug: alteplase [Activase];   Drug: alteplase placebo;   Drug: aspirin;   Drug: aspirin placebo
Sponsor:   Genentech, Inc.
Recruiting - verified February 2016

Prognostic Impact of Sleep Apnea on Cardiovascular Morbidity and Mortality, in End Stage Renal Disease Patients

Conditions:   Obstructive Sleep Apnea;   End Stage Renal Disease
Interventions:   Other: No Sleep Apnea;   Other: Sleep Apnea - untreated;   Device: Sleep Apnea - treated
Sponsor:   Centre Hospitalier Universitaire Vaudois
Recruiting - verified January 2016

CT Perfusion Imaging to Predict Vasospasm in Subarachnoid Hemorrhage

Conditions:   Subarachnoid Hemorrhage;   Delayed Cerebral Ischemia;   Cerebral Vasospasm;   CT Perfusion
Intervention:   Radiation: CT Perfusion
Sponsor:   Gwynedd Pickett
Recruiting - verified January 2016

Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection - TREAT-CAD

Condition:   Cervical Artery Dissection
Interventions:   Drug: Acetylsalicylic acid;   Drug: vitamin K-antagonist
Sponsors:   University Hospital, Basel, Switzerland;   University Hospital Inselspital, Berne;   University of Lausanne Hospitals
Recruiting - verified February 2016

Repetitive Arm Training Combined With Functional Electrical Stimulation on Upper Extremity Motor Recovery in Sub-acute Stroke Survivors

Conditions:   Stroke;   Arm Motor Recovery
Interventions:   Other: conventional therapy;   Device: arm training combined with FES
Sponsor:   University Hospital of Ferrara
Recruiting - verified February 2016

Self Abrading Rapidly Applied Electrode Validation

Condition:   ELECTROENCEPHALOGRAPHIC VARIANT PATTERN 1 (Disorder)
Interventions:   Device: SARA electrode;   Device: Gold cup
Sponsors:   Cleveland Medical Devices Inc;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified January 2016

Randomized Study Comparing Periodic Acceleration Versus Static Position in Cerebrovascular Stroke Patients

Condition:   Cerebrovascular Stroke
Intervention:   Device: Exer-Rest® TL
Sponsor:   Fundacion Rioja Salud
Recruiting - verified February 2016

Open-Label, Dose-Escalating Study to Assess Safety, Tolerability, Efficacy, PK and PD of RP103 in Children With Inherited Mitochondrial Disease

Condition:   Inherited Mitochondrial Disease, Including Leigh Syndrome
Intervention:   Drug: Cysteamine Bitartrate Delayed-release Capsules (RP103)
Sponsor:   Raptor Pharmaceuticals Inc.
Enrolling by invitation - verified June 2015

Impact of Cerebral Monitoring on Neurologic Outcome in Cardiac Surgery

Condition:   Cardiac Surgical Procedures
Intervention:   Procedure: If any intraoperative EEG abnormality and/or asymmetry is detected a cerebral CT scan will be performed in the immediate postoperative period
Sponsor:   Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Recruiting - verified January 2016

Efficacy and Safety Study of MYOBLOC® Followed by Open-Label Multiple-Treatment With MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adult Subjects

Condition:   Sialorrhea
Interventions:   Drug: MYOBLOC;   Other: PLACEBO
Sponsor:   US WorldMeds LLC
Active, not recruiting - verified February 2016

Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer

Conditions:   Breast Cancer;   Breast Tumors;   Cancer of Breast
Interventions:   Drug: Metformin;   Drug: Atorvastatin;   Procedure: Breast surgery
Sponsor:   Columbia University
Recruiting - verified February 2016

Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Hyperlipidemia or Mixed Dyslipidemia at Risk of Cardiovascular Events

Condition:   Hyperlipidemia
Interventions:   Drug: Bococizumab (PF-04950615; RN316);   Other: Placebo
Sponsor:   Pfizer
Recruiting - verified January 2016

Detection and Neurological Impact of CerebroVascular Events In Noncardiac Surgery PatIents: A COhort EvaluatioN

Condition:   Covert Postoperative Stroke
Intervention:  
Sponsors:   Hamilton Health Sciences Corporation;   McMaster University
Recruiting - verified February 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Germany)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsor:   Bayer
Recruiting - verified January 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxoban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsor:   Bayer
Recruiting - verified January 2016

Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Stroke
Interventions:   Drug: Apixaban;   Drug: aspirin
Sponsors:   Population Health Research Institute;   Bristol-Myers Squibb;   Pfizer;   Medtronic
Recruiting - verified February 2016

Telmisartan to Reduce AIDS-Related Fibrotic and Inflammatory Contributors (TRAFIC Study)

Condition:   HIV-1 Infection
Intervention:   Drug: Telmisartan
Sponsors:   AIDS Clinical Trials Group;   National Institute of Allergy and Infectious Diseases (NIAID)
Active, not recruiting - verified January 2016

Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Placebo;   Drug: Linagliptin
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified January 2016

A Study of Alegitazar in Patients With Type 2 Diabetes And Chronic Kidney Disease (Alerenal Study)

Condition:   Diabetes Mellitus, Type 2, Kidney Disease, Chronic
Interventions:   Drug: Aleglitazar;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Withdrawn - verified February 2016

A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure

Conditions:   Heart Failure;   Coronary Artery Disease
Interventions:   Drug: Rivaroxaban;   Drug: Placebo;   Other: Standard of care for heart failure and coronary artery disease
Sponsors:   Janssen Research & Development, LLC;   Bayer
Recruiting - verified January 2016

An Observational Post-Authorization Safety Specialist Cohort Event Monitoring Study (SCEM) to Monitor the Safety and Utilization of Rivaroxaban (Xarelto®).

Conditions:   Atrial Fibrillation;   Deep Vein Thrombosis;   Pulmonary Embolism
Intervention:  
Sponsors:   Professor Saad Shakir;   Bayer
Recruiting - verified January 2016

Exercise Education for Adults With Seizure Disorders

Conditions:   Seizures;   Epilepsy
Interventions:   Other: Patient Education;   Other: exercise: increase physical activity/goal setting
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2016

The Role of Biomarkers and Echocardiography in Prediction of Prognosis of Chronic Heart Failure Patients

Condition:   Heart Failure
Intervention:   Other: Observational study; no intervention.
Sponsors:   Erasmus Medical Center;   Medical Center Alkmaar
Recruiting - verified January 2016

Non-Heme Iron Load Quantification in the Brain on MRI in Patients With Hemorrhagic Stroke

Condition:   Stroke
Intervention:   Other: Non heme iron levels on MRI
Sponsor:   University of Michigan
Recruiting - verified February 2016

Anticoagulant Utilization Pattern

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified January 2016

Targeted Management Intervention for African-American Men With TIA or Stroke

Conditions:   Stroke;   Transient Ischemic Attack (TIA)
Intervention:   Behavioral: Psychoeducation
Sponsors:   Case Western Reserve University;   National Institute of Nursing Research (NINR)
Completed - verified January 2016

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention & Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute
Recruiting - verified February 2016

Determining Oral Phosphate Tolerance Across the Spectrum of Glomerular Filtration Rate

Condition:   Chronic Kidney Disease
Intervention:   Drug: Phoslax
Sponsor:   Queen's University
Recruiting - verified January 2016

HIP Surgery - Hemodynamic Optimization Project

Condition:   Redo Hip Surgery
Intervention:   Device: Stroke volume monitoring
Sponsors:   Charite University, Berlin, Germany;   Edwards Lifesciences
Completed - verified January 2016

Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation in Asia

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified February 2016

Effects of Vitamin D and Omega-3 Fatty Acids on Infectious Diseases and hCAP18 (VITAL Infection)

Conditions:   Infections;   Human Cathelicidin Antimicrobial Peptide (hCAP-18)
Interventions:   Dietary Supplement: vitamin D3;   Drug: omega-3 fatty acids (fish oil);   Dietary Supplement: Vitamin D3 placebo;   Dietary Supplement: fish oil placebo
Sponsor:   Brigham and Women's Hospital
Active, not recruiting - verified February 2016

Influence of Timing on Motor Learning

Condition:   Cerebrovascular Accident
Interventions:   Other: Conventional hand exercise;   Device: MusicGlove;   Other: Conventional Arm Exercise;   Device: Resonating Arm Exerciser
Sponsors:   University of California, Irvine;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting - verified February 2016

On-treatment PLAtelet Reactivity-guided Therapy Modification FOR ST-segment Elevation Myocardial Infarction

Condition:   Acute ST-elevation Myocardial Infarction
Intervention:   Drug: Antiplatelet Regimen Modification (aspirin or ticagrelor)
Sponsor:   Clinical Centre of Serbia
Recruiting - verified January 2016

Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: semaglutide;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Completed - verified January 2016

A Study on The Potential of Aleglitazar to Reduce Cardiovascular Risk in Patients With Stable Cardiovascular Disease and Glucose Abnormalities

Condition:   Cardiovascular Disease, Diabetes Mellitus, Type 2
Interventions:   Drug: Placebo;   Drug: aleglitazar
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

A Study to Assess Cardiovascular Outcomes Following Treatment With Omarigliptin (MK-3102) in Participants With Type 2 Diabetes Mellitus (MK-3102-018)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Omarigliptin;   Drug: Placebo
Sponsor:   Merck Sharp & Dohme Corp.
Active, not recruiting - verified January 2016

Endovascular Revascularization With Solitaire Device Versus Best Medical Therapy in Anterior Circulation Stroke Within 8 Hours

Condition:   Acute Stroke
Interventions:   Device: Solitaire FR device;   Other: Medical treatment
Sponsors:   Fundacio Ictus Malaltia Vascular;   Medtronic - MITG
Terminated - verified February 2016

Intraoperative Anuric Episodes in Patients Undergoing Laparotomy

Condition:   Intraoperative Anuria
Intervention:  
Sponsor:   Claudia Spies
Not yet recruiting - verified January 2016

A Study of Evacetrapib in High-Risk Vascular Disease

Condition:   Cardiovascular Diseases
Interventions:   Drug: Evacetrapib;   Drug: Placebo
Sponsors:   Eli Lilly and Company;   The Cleveland Clinic
Active, not recruiting - verified January 2016

Safety Study of Stem Cells Treatment in Diabetic Foot Ulcers

Conditions:   Type I Diabetes Mellitus With Ulcer;   Type II Diabetes Mellitus With Ulcer
Intervention:   Biological: ABMD-MSC
Sponsor:   Sheba Medical Center
Not yet recruiting - verified January 2016

Balance Rehabilitation With Sensory Recalibration After Stroke

Condition:   Left-sided Hemiplegia Affecting Dominant Side as Late Effect of Cerebrovascular Accident
Interventions:   Other: Cervical vibration;   Other: Prism adaptation;   Other: Conventional rehabilitation
Sponsor:   Rennes University Hospital
Recruiting - verified January 2016

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified January 2016

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab;   Drug: placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified February 2016

Brain P-gp and Inflammation in People With Epilepsy

Condition:   Epilepsies, Partial
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2015

A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Brilinta

Condition:   Acute Coronary Syndromes
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified January 2016

Stimulation With Wire Leads to Restore Cough

Conditions:   Spinal Cord Injuries;   Spinal Cord Diseases;   Paralysis;   Central Nervous System Diseases;   Cough;   Trauma, Nervous System;   Wounds and Injuries
Interventions:   Device: Expiratory muscle stimulator;   Procedure: Implantation of device
Sponsors:   Case Western Reserve University;   MetroHealth Medical Center;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2016

Xarelto [SPAF] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban(Xarelto, BAY59-7939)
Sponsor:   Bayer
Active, not recruiting - verified February 2016

Stroke Study: Operative Strategies to Reduce Cerebral Embolic Events During Coronary Artery Bypass Surgery

Condition:   Stroke
Interventions:   Procedure: No aortic clamping;   Procedure: partial occluding clamp;   Procedure: single cross clamp;   Procedure: cross clamp and partial occluding clamp
Sponsors:   Emory University;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified January 2016

Functional Interest of Non Invasive Brain Stimulation During Physiotherapy at a Subacute Phase Post Stroke (Anodal Protocol): ReSTIM

Condition:   Stroke
Interventions:   Device: anodal tDCS (device) Eldith DC-Stimulator;   Device: Sham tDCS
Sponsor:   Hospices Civils de Lyon
Recruiting - verified January 2016

Fluorescence-guided Surgery for Low- and High-grade Gliomas

Condition:   Glioma
Interventions:   Drug: 5-Aminolevulinic acid (ALA);   Drug: Placebo - ascorbic acid
Sponsor:   St. Joseph's Hospital and Medical Center, Phoenix
Recruiting - verified January 2016

Study in Parkinson's Disease of Exercise

Condition:   Parkinson Disease
Interventions:   Behavioral: Moderate Exercise;   Behavioral: Vigorous Exercise;   Behavioral: No Intervention
Sponsors:   University of Colorado, Denver;   University of Illinois at Chicago;   University of Pittsburgh;   Rush University Medical Center;   National Institute of Neurological Disorders and Stroke (NINDS);   Northwestern University
Active, not recruiting - verified February 2016

International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Coronary Artery Disease;   Heart Diseases;   Myocardial Ischemia
Interventions:   Procedure: cardiac catheterization;   Procedure: coronary artery bypass graft surgery;   Procedure: percutaneous coronary intervention;   Behavioral: Lifestyle;   Drug: Medication
Sponsors:   New York University School of Medicine;   New York University;   Stanford University;   National Heart, Lung, and Blood Institute (NHLBI);   Albany Stratton VA Medical Center;   Cedars-Sinai Medical Center;   Columbia University;   Duke University;   East Carolina University;   Emory University;   Harvard University;   Massachusetts General Hospital;   Montreal Heart Institute;   University of British Columbia;   University of Missouri, Kansas City;   Vanderbilt University
Recruiting - verified January 2016

GLORIA-AF Registry Program - Second and Third Phases

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified January 2016

Effect of HAART Vs. Statin Treatment on Endothelial Function and Inflammation/Coagulation

Condition:   HIV-1 Infection
Interventions:   Drug: Pravastatin sodium;   Drug: Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate;   Drug: Pravastatin sodium
Sponsors:   AIDS Clinical Trials Group;   National Institute of Allergy and Infectious Diseases (NIAID)
Withdrawn - verified January 2016

Mood and Insulin Resistance in Adolescents At-Risk for Diabetes

Conditions:   Depression;   Impaired Glucose Tolerance
Interventions:   Other: The Blues Program;   Other: Hey Durham
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   National Institutes of Health Clinical Center (CC)
Completed - verified January 2016

The PERFusion Use in Stroke Evaluation Study

Condition:   Ischemic Stroke
Intervention:   Other: Computed tomography perfusion imaging
Sponsors:   California Pacific Medical Center Research Institute;   California Pacific Medical Center
Recruiting - verified February 2016

The Effects of a Rhythm and Music-based Therapy Program and Therapeutic Riding in Late Recovery Phase Following Stroke

Condition:   Stroke
Interventions:   Other: RGRM;   Other: Therapeutic riding;   Other: Receives no intervention
Sponsors:   Göteborg University;   The Sten A Olsson foundation for Research and Culture
Recruiting - verified February 2016

Study of the Natural History of FFR Guided Percutaneous Coronary Intervention

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea;   St. Jude Medical (Hong Kong) Limited
Recruiting - verified January 2016

Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee Pain

Conditions:   Autoimmune Diseases;   Systemic Inflammatory Process;   Knee Pain Chronic;   Osteoarthritis;   Rheumatoid Arthritis
Interventions:   Drug: Fish Oil;   Dietary Supplement: Vitamin D;   Other: placebo pill
Sponsors:   Brigham and Women's Hospital;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Active, not recruiting - verified January 2016

Remote Ischemic Preconditioning in High Risk Cardiovascular Surgery Patients

Conditions:   Death;   Stroke;   Low Cardiac Output Syndrome;   Myocardial Infarction;   Renal Failure;   Pulmonary Failure
Interventions:   Other: Remote ischemic preconditioning stimulus;   Other: control
Sponsor:   Queen's University
Completed - verified February 2016

The PARTNER II Trial: Placement of AoRTic TraNscathetER Valves

Condition:   Symptomatic Severe Aortic Stenosis
Interventions:   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified February 2016

Ethanol Response in Essential Tremor: Clinical and Neurophysiological Correlates

Condition:   Essential Tremor
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified March 2015

Neural Dynamics and Connectivity in Response Inhibition and Traumatic Brain Injury

Conditions:   Traumatic Brain Injury;   Stroke;   Headache;   PTSD
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   United States Department of Defense;   Center for Neuroscience and Regenerative Medicine (CNRM);   National Institutes of Health Clinical Center (CC)
Recruiting - verified January 2015

A Prospective Natural History Study of Patients With Syringomyelia

Conditions:   Syringomyelia;   Arnold Chiari Deformity
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified November 2015

Drug-Eluting Stents vs. Bare Metal Stents In Saphenous Vein Graft Angioplasty

Condition:   Saphenous Vein Graft Atherosclerosis
Interventions:   Device: Bare Metal Stent;   Device: Drug-Eluting Stent;   Drug: Blinded clopidogrel;   Drug: Placebo;   Drug: Thienopyridine (open-label)
Sponsor:   VA Office of Research and Development
Active, not recruiting - verified February 2016

Functional Neuroimaging of Cortical Plasticity in the Human Visual System

Conditions:   Stroke;   Blindness;   Vision
Intervention:  
Sponsors:   Baylor College of Medicine;   Brigham and Women's Hospital, Harvard University
Recruiting - verified January 2016

A Study With Aleglitazar in Patients With a Recent Acute Coronary Syndrome and Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Aleglitazar;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

Transcranial Direct Current Stimulation (tDCS) in Chronic Stroke Recovery

Condition:   Stroke
Intervention:   Device: tDCS
Sponsor:   University of Texas Southwestern Medical Center
Recruiting - verified February 2016

Autologous Cell Therapy After Stroke

Condition:   Stroke
Interventions:   Biological: autologous bone marrow mononuclear cell transfusion;   Biological: marrow stromal cells;   Drug: placebo
Sponsors:   University of California, Irvine;   University of California, San Diego
Withdrawn - verified February 2016

Melodic-Intonation-Therapy and Speech-Repetition-Therapy for Patients With Non-fluent Aphasia

Conditions:   Aphasia;   Stroke;   Cerebrovascular Accident;   Apoplexy;   Cerebral Infarction
Interventions:   Behavioral: Melodic Intonation Therapy;   Behavioral: Speech-Repetition-Therapy
Sponsors:   Beth Israel Deaconess Medical Center;   National Institute on Deafness and Other Communication Disorders (NIDCD)
Recruiting - verified January 2016

Non-invasive Brain Stimulation and Occupational Therapy To Enhance Stroke Recovery

Conditions:   Stroke;   Cerebrovascular Accident;   CVA;   Acute Stroke;   Acute Cerebrovascular Accident;   Apoplexy
Interventions:   Device: Transcranial Direct Current Stimulation;   Device: Transcranial Direct Current Stimulation
Sponsor:   Beth Israel Deaconess Medical Center
Active, not recruiting - verified January 2016

Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System

Conditions:   Central Nervous System Disease;   Multiple Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2015

A Study of All-Cause Mortality and Cardiovascular Morbidity in CKD Patients on Dialysis and Those Not on Renal Replacement Therapy Receiving Mircera or Reference ESAs.

Condition:   Anemia
Interventions:   Drug: ESAs (darbepoetin alfa, epoetin alfa or epoetin beta);   Drug: methoxy polyethylene glycol-epoetin beta [Mircera];   Drug: methoxy polyethylene glycol-epoetin beta [Mircera]
Sponsor:   Hoffmann-La Roche
Active, not recruiting - verified February 2016

Biomarkers of Risk of Parkinson Disease

Conditions:   Parkinson Disease;   Autonomic Nervous System Diseases;   Pure Autonomic Failure
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2015

Canadian Fabry Disease Initiative (CFDI) Enzyme Replacement Therapy (ERT) Study

Condition:   Fabry Disease
Interventions:   Drug: agalsidase alfa;   Drug: Agalsidase beta
Sponsors:   Canadian Fabry Research Consortium;   Nova Scotia Health Authority
Recruiting - verified February 2016

Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone Therapy

Condition:   Myasthenia Gravis
Interventions:   Procedure: thymectomy;   Drug: prednisone
Sponsors:   University of Alabama at Birmingham;   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified January 2016

Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia

Conditions:   Sickle Cell Disease;   Chronic Kidney Disease;   Pulmonary Hypertension
Intervention:   Drug: Erythropoietin and Hydroxyurea
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2016

In Vitro Studies on Pharmacological Regulation and Genetic Risk Factors of Peripheral Human Nociceptors

Condition:   Pain
Intervention:  
Sponsors:   The University of Texas Health Science Center at San Antonio;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified February 2016

Evaluation of Primary Chronic Autonomic Failure

Condition:   Autonomic Nervous System Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified August 2015

Retinal Arteriolar Abnormalities and CV Mortality

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Cerebrovascular Disorders;   Coronary Disease
Intervention:  
Sponsors:   University of Wisconsin, Madison;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2016

Minnesota Heart Survey - Risk Factor Survey

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Cerebrovascular Accident;   Coronary Disease;   Hypertension;   Myocardial Infarction
Intervention:  
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified February 2016

Community Structure and Cardiovascular Mortality Trends

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Myocardial Ischemia;   Cerebrovascular Disorders;   Cerebrovascular Accident
Intervention:  
Sponsors:   University of North Carolina, Chapel Hill;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified February 2016

Diagnosis of Pheochromocytoma

Condition:   Pheochromocytoma
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified January 2016

Study of Inherited Neurological Disorders

Conditions:   Ataxia;   Motor Neuron Disease;   Muscular Disease;   Muscular Dystrophy;   Peripheral Nervous System Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2016