Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

ERic Acute StrokE Recanalization (ERASER)

Condition:   Ischemic Stroke
Intervention:   Device: ERIC® and SOFIA™
Sponsor:   Universitätsklinikum Hamburg-Eppendorf
Recruiting - verified August 2015

Registry of Acute Stroke Under Novel Oral Anticoagulants - Prime

Conditions:   Ischemic Stroke;   Intracerebral Hemorrhage;   Oral Anticoagulation;   Cardiovascular Diseases;   Vascular Diseases
Intervention:   Other: not applicable (observational study)
Sponsors:   University Hospital Heidelberg;   Bayer Healthcare Pharmaceuticals, Inc./Bayer Schering Pharma;   Boehringer Ingelheim;   Bristol-Myers Squibb;   Institute of Clinical Epidemiology and Biometry, University of Würzburg, Germany (for biometry and data management)
Recruiting - verified August 2015

Evaluation of Memantine Versus Placebo on Ischemic Stroke Outcome

Conditions:   Ischemic Stroke;   Excitotoxicity;   Memantine
Interventions:   Drug: Placebo;   Drug: Memantine
Sponsor:   Mazandaran University of Medical Sciences
Not yet recruiting - verified August 2015

Remote Ischemic Conditioning for Avoiding Recurrence of Symptomatic Intracranial Atherosclerotic Stenosis (sICAS)

Condition:   Intracranial Atherosclerosis
Interventions:   Device: Doctormate® (200mmHg);   Device: Doctormate® (60mmHg)
Sponsor:   Ji Xunming
Not yet recruiting - verified August 2015

Swipe Out Stroke (SOS): Feasibility of Using a Consumer Based Electronic Application to Improve Compliance With Weight Loss in Obese Minority Stroke Patients

Condition:   Stroke
Interventions:   Behavioral: Mobile Application;   Behavioral: Food Journal;   Behavioral: Usual Care
Sponsor:   The University of Texas Health Science Center, Houston
Recruiting - verified August 2015

Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery

Conditions:   Hypotension;   Postoperative Complications;   Acute Coronary Syndrome;   Heart Failure;   Coronary Occlusion;   Stroke;   Acute Kidney Injury;   Renal Insufficiency, Chronic;   Death
Interventions:   Drug: Liberal blood pressure management;   Drug: Tight blood pressure management
Sponsor:   Miodrag Filipovic, Prof. Dr. med.
Not yet recruiting - verified August 2015

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

Condition:   Epilepsy
Intervention:   Drug: Mangafodipir
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Suspended - verified July 2015

Refeeding Syndrome in Cancer Patients

Conditions:   Refeeding Syndrome;   Cancer;   Critical Illness
Intervention:   Drug: Caloric Management Protocol
Sponsor:   University of Sao Paulo
Active, not recruiting - verified August 2015

Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection

Conditions:   HIV Infections;   Neurologic Disorders
Intervention:   Drug: Anakinra
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Johns Hopkins University Department of Neurology
Not yet recruiting - verified August 2015

Effectiveness of Theta Burst Stimulation (TBS) and Voluntary Trunk Rotation for Neglect

Condition:   Stroke
Interventions:   Device: TMS and trunk rotation;   Device: Sham TMS and trunk rotation
Sponsors:   Kowloon Hospital, Hong Kong;   The Hong Kong Polytechnic University
Recruiting - verified August 2015

HT-3951 vs. Placebo in Stroke Rehabilitation

Condition:   Ischemic Stroke
Interventions:   Drug: HT-3951;   Drug: Placebo
Sponsor:   Dart NeuroScience, LLC
Not yet recruiting - verified August 2015

GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Type IV Thoracoabdominal Aortic Aneurysms Involving the Visceral Branch Vessels

Condition:   Thoracoabdominal Aortic Aneurysm
Intervention:   Device: GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis
Sponsor:   W.L.Gore & Associates
Not yet recruiting - verified August 2015

The Effect of Blood Pressure on Cerebral Perfusion During Vascular Surgery

Conditions:   Anesthesia;   Peripheral Arterial Diseases
Interventions:   Other: MAP maintained at 80 mmHg;   Other: MAP maintained at 60 mmHg
Sponsor:   Rigshospitalet, Denmark
Recruiting - verified August 2015

Rolling Massage Decreases Pain Pressure Threshold

Condition:   Pain
Interventions:   Device: TheraBand Roller Massager;   Other: Manual Massage
Sponsor:   Memorial University of Newfoundland
Completed - verified August 2015

Efficacy of Delayed Enhancement MRI-Guided Ablation vs Conventional Catheter Ablation of Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Fibrosis
Interventions:   Procedure: MRI-Guided Ablation;   Procedure: Conventional Ablation
Sponsor:   University of Utah
Not yet recruiting - verified August 2015

Investigating the Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Restenosis in Stable Angina

Condition:   Cardiovascular Diseases
Interventions:   Dietary Supplement: Beetroot Juice;   Dietary Supplement: Beetroot Juice
Sponsors:   Queen Mary University of London;   Imperial College London
Not yet recruiting - verified August 2015

A Comparison of B Type Natriuretic Peptide Levels and Hemodynamics Using the Nexfin Device in Healthy Pregnant and Preeclamptic Women - A Pilot Study

Conditions:   Preeclampsia;   Maternal;   Hypertension;   Pregnancy
Intervention:   Device: Sphygmomanometer
Sponsor:   University of California, Irvine
Recruiting - verified June 2015

O2 Consumption Study in COPD Patients

Condition:   Chronic Obstructive Pulmonary Disease (COPD)
Interventions:   Drug: Budesonide 160 mcg and formoterol fumarate dehydrate 4.5 mcg Inhalation aerosol;   Drug: Matching Placebo pMDI 160/4.5 μg
Sponsors:   AstraZeneca;   Quintiles
Not yet recruiting - verified August 2015

ARISE: After 8 Hours Reperfusion in Ischemic Stroke Embolization

Condition:   Ischemic Stroke
Intervention:   Device: Penumbra system, TREVO, or Solitaire
Sponsor:   Abington Memorial Hospital
Recruiting - verified August 2015

Addressing Real-world Anticoagulant Management Issues in Stroke

Conditions:   Stroke;   Cerebrovascular Stroke;   Intracerebral Hemorrhage
Intervention:  
Sponsors:   Duke University;   Janssen, LP;   Genentech, Inc.;   Daiichi Sankyo Inc.;   American Heart Association
Not yet recruiting - verified May 2015

Effect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus
Interventions:   Biological: Albiglutide 30 mg;   Biological: Albiglutide 50 mg;   Biological: Albiglutide matching placebo
Sponsors:   GlaxoSmithKline;   Duke Clinical Research Institute
Recruiting - verified August 2015

Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis

Condition:   Aortic Stenosis
Intervention:   Procedure: surgical aortic valve replacement
Sponsor:   Clinical Centre of Serbia
Recruiting - verified August 2015

Clear-Road Trial, Investigating the Efficacy of the RoadSaver Stent

Condition:   Peripheral Arterial Disease
Intervention:   Device: RoadSaver stent
Sponsor:   Flanders Medical Research Program
Recruiting - verified August 2015

Ablation Verses Anti-arrhythmic Therapy for Reducing All Hospital Episodes From Recurrent Atrial Fibrillation

Conditions:   Heart Failure;   Recurrent Atrial Fibrillation
Interventions:   Procedure: AVATAR-AF ablation;   Drug: Anti-Arrhythmic therapy;   Procedure: Conventional AF ablation
Sponsor:   Imperial College London
Recruiting - verified August 2015

Study Apixaban to Vitamin K Antagonist for the Prevention of Stroke or Systemic Embolism and Bleeding in Patients With Non-valvular Atrial Fibrillation and Acute Coronary Syndrome/Percutaneous Coronary Intervention

Condition:   Acute Coronary Syndromes
Interventions:   Drug: Apixaban;   Drug: vitamin K antagonist;   Drug: Acetylsalicylic acid;   Other: Acetylsalicylic acid placebo
Sponsors:   Bristol-Myers Squibb;   Pfizer;   Duke Clinical Research Institute
Recruiting - verified August 2015

Informal Caregivers ANSWERS

Conditions:   Stroke;   Traumatic Rain Injury
Interventions:   Behavioral: ANSWERS - Acquiring New Skills While Enhancing Remaining Strengths;   Other: Control
Sponsor:   Department of Veterans Affairs
Recruiting - verified August 2015

Pipeline™ Flex Embolization Device With Shield Technology™ Clinical Study

Condition:   Aneurysm
Intervention:  
Sponsor:   Medtronic Neurovascular Clinical Affairs
Recruiting - verified August 2015

Benefits of Exercise Training in Women With Ischemic Syndrome

Condition:   Microvascular Coronary Dysfunction
Intervention:   Behavioral: Exercise training
Sponsor:   Cedars-Sinai Medical Center
Not yet recruiting - verified August 2015

Do Arterial Catheters Reduce the Risk of Major Perioperative Complications

Condition:   Postoperative Complications
Interventions:   Procedure: non-cardiac surgery;   Other: arterial catheter
Sponsor:   The Cleveland Clinic
Recruiting - verified August 2015

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

Conditions:   FTLD;   Progressive Supranuclear Palsy (PSP);   Frontotemporal Dementia (FTD);   Corticobasal Degeneration (CBD);   PPA Syndrome;   Behavioral Variant Frontotemporal Dementia (bvFTD);   Semantic Variant Primary Progressive Aphasia (svPPA);   Nonfluent Variant Primary Progressive Aphasia (nfvPPA);   FTD With Amyotrophic Lateral Sclerosis (FTD/ALS);   Amyotrophic Lateral Sclerosis (ALS);   Oligosymptomatic PSP (oPSP);   Corticobasal Syndrome (CBS)
Intervention:  
Sponsors:   University of California, San Francisco;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   The Bluefield Project to cure frontotemporal dementia;   Tau Consortium
Recruiting - verified August 2015

Uninterrupted Dabigatran Etexilate in Comparison to Uninterrupted Warfarin in Pulmonary Vein Ablation (RE-CIRCUIT)

Condition:   Atrial Fibrillation
Interventions:   Drug: Warfarin;   Drug: Dabigatran Etexilate 150mg
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2015

Resistive Training Combined With Nutritional Therapy After Stroke

Condition:   Stroke
Interventions:   Other: Protein;   Other: Placebo
Sponsors:   Department of Veterans Affairs;   Baltimore VA Medical Center
Recruiting - verified August 2015

Evaluation of the Effectiveness of Eliquis ® (Apixaban) Risk Minimization Tools in European Economic Area (EEA) Countries

Condition:   Stroke, Systemic Embolism, VTEt and VTEp
Intervention:  
Sponsors:   Bristol-Myers Squibb;   Pfizer
Not yet recruiting - verified August 2015

Role of PPAR-y Anonists in Immunomodulation and Vascular Prevention in SLE (PPAR-SLE)

Condition:   Systemic Lupus Erthematosus
Interventions:   Radiation: PET/CT;   Drug: Pioglitazone;   Procedure: Vascular function studies
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified December 2014

Myoelectric Robot-assisted Rehabilitation for the Upper Limb After Stroke

Condition:   Stroke
Interventions:   Device: The RehaARM-Robot;   Behavioral: Standard rehabilitation therapy
Sponsors:   IRCCS San Camillo, Venezia, Italy;   FerRobotics Compliant Robot GmbH, Linz, Austria
Recruiting - verified August 2015

Phenotype, Genotype & Biomarkers in ALS and Related Disorders

Conditions:   Amyotrophic Lateral Sclerosis;   Frontotemporal Dementia;   Primary Lateral Sclerosis;   Hereditary Spastic Paraplegia;   Progressive Muscular Atrophy;   Multisystem Proteinopathy
Intervention:  
Sponsors:   University of Miami;   National Institute of Neurological Disorders and Stroke (NINDS);   National Center for Advancing Translational Science (NCATS);   St. Jude Children's Research Hospital
Recruiting - verified August 2015

Magnetic Resonance Imaging Evaluation of the Tissular Oxygen Saturation in Brain

Conditions:   Cerebral Tumor;   Stroke
Intervention:   Other: imaging
Sponsors:   University Hospital, Grenoble;   Université Joseph Fourier;   Institut National de la Santé Et de la Recherche Médicale, France;   France: Centre National de la Recherche Scientifique
Recruiting - verified August 2015

Norwegian Occipital Ischemic Stroke Study

Conditions:   Ischemic Stroke;   Visual Field Defect
Intervention:   Other: Training with vision teacher (visual rehabilitation)
Sponsors:   Haukeland University Hospital;   Helse Stavanger HF;   St. Olavs Hospital;   Statped Vest;   Stavanger Municipality
Active, not recruiting - verified August 2015

RuSsian RegisTry of Acute CoronaRy SyndromE TreAtMent and Approach in Dual Antiplatelet Therapy

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified August 2015

Paired Associative Stimulation in Post-stroke Hand Motor Deficits

Condition:   Stroke
Intervention:   Device: PAS
Sponsor:   Institut National de la Santé Et de la Recherche Médicale, France
Recruiting - verified August 2015

Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability

Conditions:   Chronic Troublesome Sialorrhea;   Cerebral Palsy;   Stroke;   Traumatic Brain Injury;   Intellectual Disability
Interventions:   Drug: IncobotulinumtoxinA;   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Recruiting - verified August 2015

A Long-Term Safety Trial of Treatment With Nebulized SUN-101 in Patients With COPD

Condition:   Chronic Obstructive Pulmonary Disease (COPD)
Interventions:   Drug: Glycopyrrolate (SUN-101 );   Drug: tiotropium (Spiriva®)
Sponsor:   Sunovion Respiratory Development Inc.
Active, not recruiting - verified August 2015

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified August 2015

Induction of Migraine Aura With Cilostazol

Conditions:   Migraine With Aura;   Stroke
Interventions:   Drug: Cilostazol;   Drug: Placebo
Sponsor:   Herlev Hospital
Completed - verified August 2015

Drug Persistence/Adherence in Patients Treated With Dabigatran or VKA for Stroke Prevention in Non Valvular Atrial Fibrillation (SPAF)

Condition:   Atrial Fibrillation
Interventions:   Drug: Dabigatran etexilate;   Drug: Phenprocoumon
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2015

Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

Conditions:   Stroke;   Secondary Prevention
Interventions:   Drug: optional ASA as comedication;   Drug: placebo to ASA;   Drug: placebo to optional ASA as comedication;   Drug: placebo to dabigatran etexilate;   Drug: ASA 100 mg;   Drug: dabigatran etexilate
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2015

Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Post-Stroke Spasticity

Condition:   Spasticity
Interventions:   Device: repetitive Transcranial Magnetic Stimulation (rTMS);   Device: Sham repetitive Transcranial Magnetic Stimulation
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Active, not recruiting - verified August 2015

Efficacy of an Attentional Process Training Using Competitive Versus Non Competitive Strategies

Conditions:   Stroke;   Brain Injuries
Interventions:   Behavioral: Competitive training;   Behavioral: Non-Competitive Training
Sponsors:   Hospitales Nisa;   Universidad Politécnica de Valencia;   University of Seville
Completed - verified August 2015

Walking Effect of Long Term Ticagrelor in Subjects With PAD Who Have Undergone EVR

Condition:   Peripheral Artery Disease (PAD)
Interventions:   Drug: Ticagrelor;   Drug: Comparator
Sponsors:   AstraZeneca;   CPC Clinical Research
Recruiting - verified August 2015

The Effects of tDCS Combined With Balance Training on Postural Control and Spasticity in Chronic Stroke Patients

Conditions:   Ischemic Stroke;   Spastic Gait
Interventions:   Device: Trance cranial direct current stimulation (tDCS);   Device: Sham
Sponsor:   Shahid Beheshti Medical University
Recruiting - verified August 2015

Active Surveillance Research Program for the Assessment of the Safety and the Effectiveness of Linagliptin

Condition:   Diabetes Mellitus, Type 2
Intervention:  
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified August 2015

Prospective Study on Embolization of Intracranial Aneurysms With Pipeline™ Embolization Device

Condition:   Intracranial Aneurysm
Intervention:   Device: Pipeline™ Embolization Device/ Pipeline™Flex Embolization Device
Sponsor:   Medtronic Neurovascular Clinical Affairs
Recruiting - verified August 2015

ESTEEM - Effect of Simple, Targeted Diet in Pregnant Women With Metabolic Risk Factors on Pre-eclampsia

Conditions:   Pre-eclampsia;   Obesity;   Raised Lipids;   High Blood Pressure;   Insulin Resistance
Interventions:   Behavioral: Targeted ESTEEM diet;   Other: Non-randomised cohort
Sponsor:   Queen Mary University of London
Recruiting - verified May 2014

Evaluation of the ReVive SE Device for Intra-Arterial Thrombectomy in Acute Ischemic Stroke

Condition:   Stroke
Intervention:  
Sponsor:   Codman & Shurtleff
Recruiting - verified August 2015

Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)

Conditions:   Atrial Fibrillation;   Percutaneous Coronary Intervention
Interventions:   Drug: Dabigatran Etexilate 110mg;   Drug: Warfarin 3mg;   Drug: Aspirin;   Drug: Dabigatran Etexilate 150mg;   Drug: Clopidogrel or Ticagrelor;   Drug: Clopidogrel or Ticagrelor;   Drug: Warfarin 5mg;   Drug: Clopidogrel or Ticagrelor;   Drug: Warfarin 1mg
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2015

A Blinded Study to Evaluate Effect on Atrial Fibrillation Burden in Patients With Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Interventions:   Drug: BMS-919373;   Drug: Placebo (Matching with BMS-919373)
Sponsor:   Bristol-Myers Squibb
Recruiting - verified April 2015

Vascular Function and Uterine Fibroids

Condition:   Leiomyoma
Interventions:   Device: Brachial artery catheter;   Drug: Acetylcholine;   Drug: Nitroprusside;   Drug: Norepinephrine;   Drug: Nitroprusside and phenylephrine
Sponsor:   Mayo Clinic
Recruiting - verified August 2015

Short-term Dual Anti Platelet Therapy in Patients With ACS Treated With the COMBO Dual-therapy Stent

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Treatment 90 days DAPT;   Drug: Treatment 360 days DAPT
Sponsor:   Diagram B.V.
Recruiting - verified August 2015

Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia

Condition:   Eligible Men or Women Considered High Risk for Atherosclerotic Cardiovascular Disease (CVD)
Interventions:   Drug: Epanova® (omega-3 carboxylic acids);   Drug: corn oil control
Sponsors:   AstraZeneca;   The Cleveland Clinic
Recruiting - verified August 2015

Combined Bronchodilators in Chronic Obstructive Pulmonary Disease and the Risk of Adverse Cardio-pulmonary Events

Condition:   Pulmonary Disease, Chronic Obstructive
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified August 2015

fMRI Neurofeedback for Motor Rehabilitation

Conditions:   Stroke;   fMRI
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 2015

Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions

Conditions:   Chronic Troublesome Sialorrhea;   Parkinson's Disease;   Post-stroke;   Traumatic Brain Injury
Interventions:   Drug: IncobotulinumtoxinA (100 Units);   Drug: IncobotulinumtoxinA (75 Units);   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Active, not recruiting - verified August 2015

A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease

Conditions:   Coronary Disease;   Coronary Stenosis
Interventions:   Procedure: FFR guided PCI;   Procedure: CABG
Sponsors:   Stanford University;   VZW Cardiovascular Research Center Aalst;   Catharina Hospital Eindhoven;   Golden Jubilee National Hospital;   University of California, Irvine;   Medtronic;   St. Jude Medical;   Genae;   King's College Hospital, London;   Houston Methodist DeBakey Heart and Vascular Center, Houston
Recruiting - verified August 2015

Sequential Expansion of Comparative Effectiveness of Anticoagulants

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2015

A Study of the Efficacy and Safety of Activase (Alteplase) in Patients With Mild Stroke (PRISMS)

Condition:   Brain Ischemia
Interventions:   Drug: alteplase [Activase];   Drug: alteplase placebo;   Drug: aspirin;   Drug: aspirin placebo
Sponsor:   Genentech, Inc.
Recruiting - verified August 2015

Improving the Quality of Cardiopulmonary Resuscitation (CPR) During Pediatric Cardiac Arrest

Condition:   Cardiac Arrest
Interventions:   Device: CPRcard;   Other: Just in Time Video
Sponsors:   Express Collaborative;   Canadian Institutes of Health Research  (CIHR);   Heart and Stroke Foundation of Canada
Completed - verified August 2015

Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic VTE(Venous Thromboembolism)

Conditions:   Pulmonary Embolism;   Thromboembolism;   Thrombosis;   Venous Thrombosis;   Venous Thromboembolism
Interventions:   Drug: BAY 59-7939;   Drug: BAY 59-7939;   Drug: ASA
Sponsor:   Bayer
Recruiting - verified August 2015

Study Of The Blood Thinner, Apixaban, For Patients Who Have An Abnormal Heart Rhythm (Atrial Fibrillation) And Expected To Have Treatment To Put Them Back Into A Normal Heart Rhythm (Cardioversion)

Condition:   Atrial Fibrillation
Interventions:   Drug: Apixaban;   Drug: Parenteral heparin and/or oral Vitamin K antagonist
Sponsors:   Pfizer;   Bristol-Myers Squibb
Recruiting - verified August 2015

BAY 59-7939 (Xarelto, SPAF), Non Interventional Studies

Condition:   Atrial Fibrillation
Interventions:   Drug: Phenprocoumon (Marcumar);   Drug: Rivaroxaban (Xarelto, BAY-59 7939)
Sponsor:   Bayer
Completed - verified August 2015

Trevo® Retriever Registry Post Market Surveillance

Condition:   Ischemic Stroke
Intervention:  
Sponsor:   Stryker Neurovascular
Recruiting - verified August 2015

Understanding the Exercise-Hypertension Paradox

Condition:   Hypertension
Interventions:   Dietary Supplement: Oral Antioxidant;   Other: Exercise rehabilitation
Sponsor:   Department of Veterans Affairs
Recruiting - verified August 2015

Stroke Feasibility Study

Conditions:   Atrial Fibrillation;   AFib
Intervention:   Device: AtriClip LAA Exclusion Device
Sponsor:   AtriCure, Inc.
Completed - verified August 2015

Efficacy and Safety Study of MYOBLOC® Followed by Open-Label Multiple-Treatment With MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adult Subjects

Condition:   Sialorrhea
Intervention:   Drug: MYOBLOC
Sponsor:   US WorldMeds LLC
Recruiting - verified August 2015

Established Status Epilepticus Treatment Trial

Condition:   Benzodiazipine Refractory Status Epilepticus
Interventions:   Drug: Fosphenytoin;   Drug: Levetiracetam;   Drug: Valproic acid
Sponsors:   University of Virginia;   University of Michigan;   Medical University of South Carolina;   Children's Research Institute;   University of Minnesota - Clinical and Translational Science Institute;   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified August 2015

Detection and Neurological Impact of CerebroVascular Events In Noncardiac Surgery PatIents: A COhort EvaluatioN

Condition:   Covert Postoperative Stroke
Intervention:  
Sponsors:   Hamilton Health Sciences Corporation;   McMaster University
Recruiting - verified August 2015

Ticagrelor vs High Dose Clopidogrel in Patients With ST Elevation Myocardial Infarction Post Fibrinolysis

Conditions:   ST Elevation Myocardial Infarction;   Fibrinolysis;   P2Y12 Inhibitor
Interventions:   Drug: Ticagrelor 180mg loading dose and 90mg bid maintenance dose;   Drug: Clopidogrel 600mg loading dose and 150mg maintenance dose
Sponsor:   University of Patras
Completed - verified August 2015

GLORIA-AF Registry Program (Phase II/III)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2015

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)

Condition:   Pulmonary Embolism
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Warfarin
Sponsor:   Bayer
Recruiting - verified August 2015

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)

Condition:   Pulmonary Embolism
Interventions:   Drug: Rivaroxoban (Xarelto, Bay59-7939);   Drug: Acenocoumarol
Sponsor:   Bayer
Recruiting - verified August 2015

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Germany)

Condition:   Pulmonary Embolism
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Phenprocoumon
Sponsor:   Bayer
Recruiting - verified August 2015

A Study of Post-Stroke Pain and Fatigue: Clinical Evaluation and Treatment Effect

Condition:   Stroke
Interventions:   Device: Combined Therapy of FES and BAT;   Device: Conventional Rehabilitation
Sponsors:   Chang Gung University;   Mackay Memorial Hospital;   Chang Gung Memorial Hospital
Recruiting - verified August 2015

tDCS and Aphasia Treatment

Condition:   Aphasia
Intervention:   Device: Soterix 1x1 tDCS
Sponsor:   Hunter College
Recruiting - verified August 2015

Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Placebo;   Drug: Linagliptin
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified August 2015

Cognition and Exercise Training

Conditions:   Metabolic Syndrome;   Coronary Heart Disease;   Chronic Heart Failure
Interventions:   Other: high intensity interval training (HIIT);   Other: moderate intensity continuous exercise training
Sponsor:   Montreal Heart Institute
Recruiting - verified August 2015

A Study of Alegitazar in Patients With Type 2 Diabetes And Chronic Kidney Disease (Alerenal Study)

Condition:   Diabetes Mellitus, Type 2, Kidney Disease, Chronic
Interventions:   Drug: Aleglitazar;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Withdrawn - verified August 2015

A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure

Conditions:   Heart Failure;   Coronary Artery Disease
Interventions:   Drug: Rivaroxaban;   Drug: Placebo;   Other: Standard of care for heart failure and coronary artery disease
Sponsors:   Janssen Research & Development, LLC;   Bayer
Recruiting - verified August 2015

Focal Cortical Atrophy After Myocardial Internal Capsule

Condition:   Ischemic Stroke Involving Corticospinal Tract.
Intervention:   Other: Additional MRI
Sponsor:   University Hospital, Toulouse
Completed - verified August 2015

GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS)

Condition:   Amyotrophic Lateral Sclerosis
Intervention:   Drug: GM604
Sponsors:   Genervon Biopharmaceuticals, LLC;   Columbia University;   Massachusetts General Hospital
Completed - verified August 2015

Phase 2A Study of GM 608 in Mild to Moderate Parkinson Disease

Condition:   Parkinson's Disease
Intervention:   Drug: GM608
Sponsors:   Genervon Biopharmaceuticals, LLC;   Columbia University
Completed - verified August 2015

Anticoagulant Utilization Pattern

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2015

Effects of a Community-based Group Rehabilitation Program for Dynamic Balance and Mobility Post Stroke

Condition:   Sequelae of Stroke
Interventions:   Behavioral: conventional physical therapy;   Behavioral: community-based group rehabilitation
Sponsors:   University of Manitoba;   Manitoba Medical Service Foundation
Recruiting - verified March 2013

Study of Procoagulation Markers in Stroke Patients

Conditions:   Stroke;   Hyperglycemia;   Procoagulation Markers
Intervention:   Other: Glycemic Control
Sponsors:   Temple University;   National Institute of Neurological Disorders and Stroke (NINDS);   Neurological Emergencies Treatment Trials Network (NETT);   University of Virginia;   University of Michigan;   Medical University of South Carolina;   Georgia Regents University
Recruiting - verified August 2015

A Study Exploring Two Strategies of Rivaroxaban (JNJ39039039; BAY-59-7939) and One of Oral Vitamin K Antagonist in Patients With Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention

Conditions:   Atrial Fibrillation;   Percutaneous Coronary Intervention
Interventions:   Drug: rivaroxaban 2.5 mg;   Drug: rivaroxaban 15 mg;   Drug: rivaroxaban 10 mg;   Drug: aspirin (ASA);   Drug: vitamin K antagonist (VKA);   Drug: clopidogrel;   Drug: prasugrel;   Drug: ticagrelor
Sponsors:   Janssen Scientific Affairs, LLC;   Bayer
Active, not recruiting - verified August 2015

Prehospital Cerebral Oxygenation During Cardiopulmonary Resuscitation (CPR)

Condition:   Cardiac Arrest
Intervention:  
Sponsors:   Hasselt University;   Ziekenhuis Oost-Limburg
Recruiting - verified August 2015

Surgical Pulmonary Vein Isolation Efficiency Study

Conditions:   Paroxysmal Atrial Fibrillation;   Coronary Artery Disease
Interventions:   Procedure: CABG, AVR or CABG+AVR and PVI;   Procedure: CABG, AVR or CABG+AVR
Sponsor:   Kuopio University Hospital
Terminated - verified August 2015

Decision Support for Smoking Cessation in Young Adults With Severe Mental Illness

Conditions:   Mental Illness;   Tobacco Smoking;   Psychotic Disorders
Intervention:   Behavioral: Electronic Decision Support System
Sponsors:   Dartmouth-Hitchcock Medical Center;   National Cancer Institute (NCI)
Active, not recruiting - verified August 2015

The GReek AntiPlatElet (GRAPE) Registry: A Multicenter Observational Prospective Investigation of Antiplatelet Treatment in Patients With Acute Coronary Syndrome Subjected to Percutaneous Coronary Intervention

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsors:   University of Patras;   Hellenic Cardiological Society
Completed - verified August 2015

SPARK: Safety Study of Pradaxa in Atrial Fibrillation Patients by Regulatory Requirement of Korea

Condition:   Atrial Fibrillation
Intervention:   Drug: Pradaxa (Dabigatran etexilate mesilate)
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2015

A Study on The Potential of Aleglitazar to Reduce Cardiovascular Risk in Patients With Stable Cardiovascular Disease and Glucose Abnormalities

Condition:   Cardiovascular Disease, Diabetes Mellitus, Type 2
Interventions:   Drug: Placebo;   Drug: aleglitazar
Sponsor:   Hoffmann-La Roche
Completed - verified August 2015

A Study to Assess Cardiovascular Outcomes Following Treatment With Omarigliptin (MK-3102) in Participants With Type 2 Diabetes Mellitus (MK-3102-018)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Omarigliptin;   Drug: Placebo
Sponsor:   Merck Sharp & Dohme Corp.
Active, not recruiting - verified August 2015

Endovascular Revascularization With Solitaire Device Versus Best Medical Therapy in Anterior Circulation Stroke Within 8 Hours

Condition:   Acute Stroke
Interventions:   Device: Solitaire FR device;   Other: Medical treatment
Sponsors:   Fundacio Ictus Malaltia Vascular;   Medtronic - MITG
Terminated - verified August 2015

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2015

Determination of CRIM Status and Longitudinal Follow-up of Individuals With Pompe Disease

Condition:   Pompe Disease
Intervention:   Other: Observational
Sponsors:   Duke University;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified August 2015

Effects of tDCS Versus HD-tDCS for Stroke Rehabilitation

Condition:   Chronic Aphasia
Interventions:   Device: HD-tDCS (Soterix);   Device: Transcranial Direct Current Stimulation (Neuroconn)
Sponsors:   Soterix Medical;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified August 2015

A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Brilinta

Condition:   Acute Coronary Syndromes
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified August 2015

Safety and Effectiveness of Intra-coronary Nitrite in Acute Myocardial Infarction

Conditions:   Myocardial Infarction;   Reperfusion Injury;   Myocardial Ischemia;   Cardiovascular Diseases
Interventions:   Drug: Sodium Nitrite;   Drug: Sodium Chloride Placebo
Sponsors:   Barts & The London NHS Trust;   Queen Mary University of London
Active, not recruiting - verified July 2015

Xarelto [SPAF-QOL] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban (Xarelto_ BAY59-7939)
Sponsor:   Bayer
Recruiting - verified August 2015

Xarelto [SPAF] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban(Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified August 2015

Left Atrial Appendage Occlusion Study III

Conditions:   Cardiac Surgery With Cardiopulmonary Bypass;   Atrial Fibrillation
Intervention:   Other: Left Atrial Appendage Occlusion
Sponsor:   Population Health Research Institute
Recruiting - verified August 2015

Coronary Hybrid Revascularisation Study

Condition:   Significant Coronary Artery Disease
Intervention:   Procedure: Combined CABG and PCI
Sponsor:   Aarhus University Hospital Skejby
Active, not recruiting - verified August 2015

Post-Marketing Surveillance of Prazaxa® on the Long-term Use in Patients With Nonvalvular Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Drug: Prazaxa
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified August 2015

Life After STroke - the LAST Study

Conditions:   Cerebral Infarction;   Cerebral Hemorrhage
Interventions:   Behavioral: Long term follow up by a coordinating physiotherapist;   Behavioral: Standard care
Sponsors:   Norwegian University of Science and Technology;   St. Olavs Hospital;   Asker & Baerum Hospital;   The Research Council of Norway;   Helse Midt-Norge
Active, not recruiting - verified August 2015

GLORIA-AF Registry Program - Second and Third Phases

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2015

Continuous Chest Compressions vs AHA Standard CPR of 30:2

Condition:   Out of Hospital Cardiac Arrest
Interventions:   Other: Standard CPR;   Other: Continuous chest compressions
Sponsors:   University of Washington;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research  (CIHR);   Heart and Stroke Foundation of Canada;   American Heart Association;   Defence Research and Development Canada;   U.S. Army Medical Research and Materiel Command
Active, not recruiting - verified August 2015

A Study of RoActemra/Actemra (Tocilizumab) in Comparison to Etanercept in Patients With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors

Condition:   Cardiovascular Disease, Rheumatoid Arthritis
Interventions:   Drug: etanercept;   Drug: tocilizumab [RoActemra/Actemra]
Sponsor:   Hoffmann-La Roche
Active, not recruiting - verified August 2015

Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement

Condition:   Severe Aortic Stenosis
Interventions:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI);   Device: Surgical Aortic Valve Replacement (SAVR)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting - verified August 2015

Efficacy and Safety Study of GM602 in Patients With Acute Middle Cerebral Artery Ischemic Stroke Within 18 Hours

Condition:   Stroke
Interventions:   Drug: GM602;   Drug: Matching Placebo (Bacteriostatic Saline) for GM602
Sponsors:   Genervon Biopharmaceuticals, LLC;   University of California, Los Angeles;   Huntington Hospital;   Hoag Memorial Hospital Presbyterian;   Columbia University;   California Pacific Medical Center Research Institute;   University Hospital Erlangen;   Sarasota Memorial Hospital;   University of Louisville
Recruiting - verified August 2015

Sympathetic Activity in Patients With End-stage Renal Disease on Peritoneal Dialysis

Conditions:   End-stage Renal Disease (ESRD);   Kidney Disease
Interventions:   Other: DIANEAL;   Other: EXTRANEAL
Sponsors:   Ottawa Hospital Research Institute;   Heart and Stroke Foundation of Ontario
Recruiting - verified August 2015

Clinical Study of the L300 Versus Ankle-foot Orthosis (AFO) on Post-Stroke Subjects With Foot Drop

Conditions:   Sensorimotor Gait Disorder;   Neurologic Ambulation Disorder;   Gait, Drop Foot;   Poststroke/CVA Hemiparesis
Interventions:   Device: Ness L300;   Device: Ness L300
Sponsors:   Bioness Inc;   Medidata Solutions;   University of Cincinnati
Completed - verified August 2015

Reducing Risk of Recurrence

Conditions:   Stroke;   TIA;   Hypertension;   Hyperlipidemia
Interventions:   Behavioral: TI;   Behavioral: AP
Sponsor:   Department of Veterans Affairs
Completed - verified August 2015

A Study With Aleglitazar in Patients With a Recent Acute Coronary Syndrome and Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Aleglitazar;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Completed - verified August 2015

SISTERS: Spasticity In Stroke Study - Randomized Study

Condition:   Severe Spasticity
Intervention:   Drug: intrathecal baclofen
Sponsor:   Medtronic International Trading Sarl
Recruiting - verified August 2015

CANVAS - CANagliflozin cardioVascular Assessment Study

Conditions:   Diabetes Mellitus, Type 2;   Cardiovascular Diseases;   Risk Factors
Interventions:   Drug: Canagliflozin (JNJ-28431754);   Drug: Placebo
Sponsors:   Janssen Research & Development, LLC;   The George Institute for Global Health, Australia
Active, not recruiting - verified August 2015

Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System

Conditions:   Central Nervous System Disease;   Multiple Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2015

A Study of All-Cause Mortality and Cardiovascular Morbidity in CKD Patients on Dialysis and Those Not on Renal Replacement Therapy Receiving Mircera or Reference ESAs.

Condition:   Anemia
Interventions:   Drug: ESAs (darbepoetin alfa, epoetin alfa or epoetin beta);   Drug: methoxy polyethylene glycol-epoetin beta [Mircera];   Drug: methoxy polyethylene glycol-epoetin beta [Mircera]
Sponsor:   Hoffmann-La Roche
Active, not recruiting - verified August 2015

Thiazolidinediones Or Sulphonylureas and Cardiovascular Accidents.Intervention Trial

Conditions:   Type 2 Diabetes Mellitus;   Cardiovascular Disease
Interventions:   Drug: add-on pioglitazone;   Drug: add-on sulphonylurea
Sponsors:   Italian Society of Diabetology;   Associazione Medici Diabetologi (AMD);   Associazione Nazionale Medici Cardiologi Ospedalieri
Active, not recruiting - verified August 2015

Natural History Study of Patients With Neurofibromatosis Type 2

Conditions:   Spinal Cord Disease;   Intracranial Central Nervous System Disorder;   Neurologic Disorders;   Brain Neoplasms
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified September 2014

Muscular Strengthening for Paretic Knee Flexor and Extensor by Conventional Physiotherapy on Chronic Hemiplegic Stroke Patients

Conditions:   Hemiplegia;   Stroke
Interventions:   Procedure: Muscular Strengthening for paretic knee flexor and extensor;   Other: conventional physiotherapy
Sponsors:   University Hospital, Toulouse;   University Hospital, Bordeaux;   University Hospital, Limoges
Completed - verified August 2015

An Implantable Microstimulator for the Treatment of Chronic Shoulder Pain in Chronic Post-Stroke Subjects

Condition:   Shoulder Pain Chronic
Intervention:   Device: Battery Powered Microstimulator (BBPM)
Sponsor:   Bioness Inc
Completed - verified November 2011

Carotid Plaque Regression With Statin Treatment Assessed by High Field Magnetic Resonance Imaging (MRI)

Condition:   Carotid Atherosclerosis
Intervention:  
Sponsor:   Medical College of Wisconsin
Withdrawn - verified August 2015

Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen

Condition:   Arthritis, Rheumatoid
Interventions:   Drug: celecoxib;   Drug: Ibuprofen;   Drug: Naproxen
Sponsors:   Pfizer;   The Cleveland Clinic
Active, not recruiting - verified August 2015

SDCC - Prospective Cohort Study of Chronic Renal Insufficiency

Condition:   Renal Insufficiency, Chronic
Intervention:  
Sponsors:   University of Pennsylvania;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   Johns Hopkins University;   Case Western Reserve University;   University of Michigan;   University of Illinois at Chicago;   Tulane University;   Kaiser Permanente
Active, not recruiting - verified August 2015

Insulin Resistance Intervention After Stroke Trial

Conditions:   Stroke;   Myocardial Infarction;   Diabetes
Interventions:   Drug: pioglitazone;   Drug: placebo
Sponsors:   Yale University;   National Institute of Neurological Disorders and Stroke (NINDS);   Takeda Pharmaceuticals North America, Inc.
Active, not recruiting - verified August 2015

Familial Intracranial Aneurysm Study II

Conditions:   Intracranial Aneurysm;   Subarachnoid Hemorrhage
Intervention:  
Sponsors:   University of Cincinnati;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified August 2015

Evaluation of Primary Chronic Autonomic Failure

Condition:   Autonomic Nervous System Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2014

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