Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

" Endarterectomy Combined With Optimal Medical Therapy Versus Optimal Medical Therapy Alone in Patients With Asymptomatic Severe Atherosclerotic Carotid Artery Stenosis at Higher-than-average Risk of Ipsilateral Stroke "

Condition:   Asymptomatic Carotid Stenosis at Higher-than-average Risk of Ipsilateral Stroke
Interventions:   Other: Carotid endarterectomy (CEA) combined with optimal medical therapy (OMT);   Drug: Optimal medical therapy alone
Sponsors:   Centre Hospitalier St Anne;   Hôpitaux Universitaires Paris Ile-de-Franc Ouest
Not yet recruiting - verified July 2016

Long-term Remote Ischemic Preconditioning Improve Long-term Prognosis of Acute Myocardial Infarction Patients Without Emergency Reperfusion Therapy

Condition:   Myocardial Infarction [C14.280.647.500]
Intervention:   Other: reported remote ischemic preconditioning (RIPC)
Sponsor:   Xuanwu Hospital, Beijing
Not yet recruiting - verified July 2016

Promoting Recovery Optimization With WALKing Exercise After Stroke

Condition:   Stroke
Interventions:   Behavioral: FAST;   Behavioral: FAST+SAM;   Behavioral: SAM
Sponsors:   University of Delaware;   University of Pennsylvania;   Christiana Care Health Services
Not yet recruiting - verified July 2016

The Effect of Goal-directed Therapy Guided by Stroke Volume Variation and Cardiac Index in Non-severe Surgical Patients

Condition:   Fluid Therapy
Interventions:   Device: cardiac index;   Device: Stroke Volume Variation
Sponsor:   First Affiliated Hospital, Sun Yat-Sen University
Active, not recruiting - verified July 2016

Electrical Stimulation of the Dentate Nucleus for Upper Extremity Hemiparesis Due to Ischemic Stroke

Condition:   Stroke
Intervention:   Device: Deep Brain Stimulation
Sponsor:   Enspire DBS Therapy, Inc.
Recruiting - verified July 2016

Effect of Wheelchair Handrail Compensator and Rehabilitation Training for Patients With Hemiplegic Shoulder Pain

Condition:   Shoulder Pain
Interventions:   Device: Wheelchair handrail compensator;   Device: Ordinary wheelchair
Sponsor:   Guangzhou University of Traditional Chinese Medicine
Completed - verified July 2016

Catalytic Antibodies to Predict Uninvasively Late Transplant Failure

Condition:   Renal Transplantation
Intervention:   Other: blood samples
Sponsor:   Hospices Civils de Lyon
Completed - verified July 2016

Factors Associated to the Instability of the INR (International Normalized Ratio ) in the Prevention of Thromboembolism AVK (Anti Vitamin K) in Atrial Fibrillation in the Elderly: Instead of Comorbidities

Condition:   Older Patient
Intervention:   Other: Charlson comorbidity index
Sponsor:   Nantes University Hospital
Completed - verified July 2016

Prevention of Non-Surgical Bleeding by Management of HeartMate II Patients Without Antiplatelet Therapy

Condition:   Heart Failure
Interventions:   Device: HeartMate II (HMII);   Drug: Warfarin;   Drug: acetylsalicylic acid (ASA) therapy
Sponsor:   St. Jude Medical
Not yet recruiting - verified July 2016

Effect of Stimulation of the Prefrontal Cortex on Language Production in Aphasic Patients

Condition:   Aphasia
Interventions:   Device: transcranial direct current stimulation;   Device: Sham tDCS
Sponsors:   Jean-Marie Annoni;   University Hospital, Geneva;   Hôpital Cantonal de Fribourg
Recruiting - verified July 2016

The Effect of GLP-1 Receptor Agonist on Cerebral Blood Flow Velocity in Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: Byetta;   Drug: Normosaline
Sponsor:   Christina Kruuse
Not yet recruiting - verified July 2016

The Effect of GLP-1 Receptor Agonist on Cerebral Blood Flow Velocity in Non-stroke Volunteers

Condition:   Stroke
Interventions:   Drug: Byetta;   Drug: Isotonic saline
Sponsor:   Christina Kruuse
Not yet recruiting - verified July 2016

Efficacy and Safety of Neu2000KWL in Treating Acute Ischemic Stroke Receiving Endovascular Therapy (ENIS I)

Condition:   Ischemic Stroke
Interventions:   Drug: Neu2000KWL High-does group;   Drug: Neu2000KWL Low-does group;   Drug: Placebo
Sponsor:   GNT Pharma
Not yet recruiting - verified July 2016

3-Month Discontinuation of Dual Antiplatelet Therapy After Ultimaster Sirolimus-Eluting Stent Implantation

Condition:   Coronary Artery Disease
Interventions:   Drug: Aspirin;   Drug: Thienopyridine
Sponsor:   Teikyo University
Not yet recruiting - verified July 2016

Multimodel Magnetic Resonance Imaging (MRI)of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders

Conditions:   Multiple Sclerosis;   Neuromyelitis Optica Spectrum Disorders
Intervention:   Other: Magnetic Resonance Imaging
Sponsor:   Chinese PLA General Hospital
Recruiting - verified July 2016

Reactive Oxygen Species Following Aortic Valve Replacement

Condition:   Aortic Stenosis
Intervention:  
Sponsor:   University Hospital Southampton NHS Foundation Trust.
Recruiting - verified July 2016

Evaluation of Soluble ST2 in Patients Receiving Primary PCI With ST-elevation Myocardial Infarction

Conditions:   Myocardial Infarction;   Shock
Intervention:  
Sponsor:   Wuhan Asia Heart Hospital
Recruiting - verified July 2016

Evaluation of Diagnostic Criteria for Chronic Critical Limb Ischemia

Condition:   Stroke
Intervention:   Other: No intervention
Sponsor:   Groupe Hospitalier Paris Saint Joseph
Completed - verified July 2016

Diabetes Complication Control in Community Clinics (D4C) Trial

Conditions:   Diabetes;   Hypertension;   Dyslipidemia;   Cardiovascular Disease
Intervention:   Other: Protocol-based integrated care
Sponsors:   Tulane University Health Sciences Center;   Xiamen Diabetes Institute, Xiamen University, Xiamen, China
Not yet recruiting - verified July 2016

Acute Aerobic Exercise and Neuroplasticity in Depression

Conditions:   Depression;   Depressive Disorder
Interventions:   Behavioral: Aerobic Exercise;   Device: Paired Associative Stimulation
Sponsor:   Medical University of South Carolina
Recruiting - verified May 2016

TRANscatheter or SurgIcal Aortic Valve ReplacemenT in All-Comers With Severe Aortic Valve Stenosis

Condition:   Aortic Valve Stenosis
Interventions:   Device: SAPIEN 3;   Procedure: SAVR
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea
Not yet recruiting - verified July 2016

Patient Education Following a Stroke

Condition:   Stroke
Intervention:   Behavioral: stroke education workshops
Sponsor:   Hopital Foch
Active, not recruiting - verified June 2016

Dietary Nitrate Supplements and Ischemic Stroke Recovery

Conditions:   Stroke;   Ischemic Stroke;   Cerebrovascular Accident
Interventions:   Drug: Beet it Beetroot juice;   Drug: Beet It Placebo Beetroot juice
Sponsor:   Wake Forest School of Medicine
Completed - verified July 2016

Diffusion Spectroscopy in Stroke

Condition:   ISCHEMIC STROKE
Intervention:   Device: Magnetic resonance imaging
Sponsor:   Institut National de la Santé Et de la Recherche Médicale, France
Not yet recruiting - verified June 2016

CADASIL Disease Discovery

Conditions:   Cardiovascular Disease;   Arterial Stiffness
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified July 2016

Treatment Convenience in Patients Treated With Dabigatran for Stroke Prophylaxis in Atrial Fibrillation (SPAF)

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified July 2016

Innovative Multigenerational Household Intervention to Reduce Stroke and CVD

Conditions:   Stroke;   Cardiovascular Disease
Intervention:   Behavioral: Motivational Interviewing
Sponsor:   Washington State University
Recruiting - verified July 2016

Safety and Efficacy of Two Doses of SP-8203 in Patients With Ischemic Stroke Requiring rtPA

Condition:   Ischemic Stroke
Interventions:   Drug: SP-8203 High dose;   Drug: SP-8203 Low dose;   Drug: Placebo
Sponsor:   Shin Poong Pharmaceutical Co. Ltd.
Recruiting - verified March 2016

Exercise Intensity of a Walking Related Task-Oriented Exercise in Stroke Survivors

Condition:   Stroke
Intervention:   Procedure: Structured, Progressive, Task-oriented exercise program
Sponsor:   Mahidol University
Recruiting - verified June 2016

Efficacy of Aspirin and L-arginine in High Risk Preeclamptic

Condition:   High Risk Pregnancy
Interventions:   Drug: L-arginine;   Drug: Placebo (for L-arginine);   Drug: acetylsalicylic acid
Sponsors:   University of Guadalajara;   PhD Ernesto Javier Ramírez Lizardo;   PhD Sylvia Elena Totsuka Sutto;   PhD Fernando Grover Páez;   MD Diego Hernández Molina
Not yet recruiting - verified July 2016

Xarelto on Prevention of Stroke and Non-central Nervous System Systemic Embolism in Patients With Non-valvular Atrial Fibrillation in China: A Non-interventional Study

Condition:   Stroke
Intervention:   Drug: Rivaroxaban (Xarelto, BAY 59-7939)
Sponsor:   Bayer
Recruiting - verified July 2016

Tele-Health Electronic Monitoring to Reduce Post Discharge Complications and Surgical Site Infections

Condition:   Peripheral Vascular Disease
Intervention:   Other: Tele-Health Electronic Monitoring (THEM)
Sponsors:   CAMC Health System;   WVCTSI
Enrolling by invitation - verified July 2016

Clinical Study of Medicinal Product Cardionat® Using in Health Athlete Volunteers

Conditions:   Stroke, Not Specified as Hemorrhage or Infarction;   Angina Pectoris
Intervention:   Drug: оral intake of study drug capsules; study drug - Cardionat ® (trimethylhydrazinium propionate dihydrate), oral capsules 250 mg
Sponsor:   Burnasyan Federal Medical Biophysical Center
Recruiting - verified April 2016

The Effectiveness of Multimodal Educational Intervention to Improve Adherence to Treatment Regimens in Older Stroke Patients: A Randomised Trial

Conditions:   Stroke;   Medication Adherence;   Older Adults
Interventions:   Behavioral: Patient-based intervention;   Behavioral: Family based intervention;   Other: Routine counseling
Sponsor:   Qazvin University Of Medical Sciences
Recruiting - verified July 2016

Investigating the Effects of Cardiac Rehabilitation eXercise Modalities on Physical and Mental Health Outcomes

Condition:   Coronary Artery Disease (CAD)
Interventions:   Behavioral: High Intensity Interval Training;   Behavioral: Moderate Intensity Continuous Exercise Training;   Behavioral: Nordic Walking
Sponsors:   Ottawa Heart Institute Research Corporation;   Ontario Ministry of Health and Long Term Care;   Heart and Stroke Foundation of Canada
Recruiting - verified July 2016

Stroke Caregiver Empowerment

Condition:   Stroke
Intervention:   Behavioral: STROKE-CARE
Sponsor:   University of Pittsburgh
Recruiting - verified July 2016

Multifocal Brain Magnetic Stimulation in Chronic Ischemic Stroke

Condition:   Stroke
Intervention:   Device: Transcranial magnetic stimulation
Sponsor:   The Methodist Hospital System
Enrolling by invitation - verified July 2016

Effect of Personalized Robotic Therapy

Condition:   Stroke
Interventions:   Device: Arm Light Exoskeleton Rehab Station (ALEx RS);   Device: Arm Light Exoskeleton Rehab Station (ALEx RS) - automatically personalized
Sponsors:   Wearable Robotics srl.;   University Hospital, Geneva;   Azienda Ospedaliero, Universitaria Pisana;   École polytechnique fédérale de Lausanne
Recruiting - verified July 2016

Low Dose RT to Reduce Cerebral Amyloidosis in Early Alzheimer's

Condition:   Alzheimer's Disease
Interventions:   Radiation: 10 GY in 5 daily fractions;   Radiation: 20 GY in 10 daily fractions
Sponsor:   Virginia Commonwealth University
Recruiting - verified July 2016

Effect of iNO on Invasively Derived Pulmonary Pressures in Patients With PAH

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Nitric Oxide
Sponsor:   Allegheny Singer Research Institute
Recruiting - verified July 2016

DL-3-n-butylphthalide Treatment in Patients With Mild to Moderate Alzheimer's Disease Already Receiving Donepezil

Condition:   Alzheimer's Disease
Interventions:   Drug: DL-3-n-butylphthalide;   Drug: Donepezil
Sponsor:   First Affiliated Hospital Xi'an Jiaotong University
Recruiting - verified February 2016

A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Not yet recruiting - verified May 2016

A Novel Strategy to Decrease Fall Incidence Post-Stroke

Condition:   Stroke
Intervention:   Behavioral: Backward Walking Training
Sponsor:   VA Office of Research and Development
Not yet recruiting - verified July 2016

A Clinical Assessment Study in X-Linked Myotubular Myopathy (XLMTM) Subjects

Condition:   X-linked Myotubular Myopathy
Intervention:  
Sponsor:   Audentes Therapeutics
Recruiting - verified July 2016

Liberal Oxygenation Versus Conservative Oxygenation in ARDS

Conditions:   Acute Respiratory Distress Syndrome;   Intensive Care
Intervention:   Drug: Modulation of Inspired Fraction of Oxygen (FiO2)
Sponsor:   Centre Hospitalier Universitaire de Besancon
Recruiting - verified July 2016

The Relationship Between Clotting Factor VIII and Bleeding Adverse Reactions in Patients Under the Therapies of Thrombolysis, Anticoagulation and Anti-platelet

Conditions:   Bleeding;   Ischemic Stroke
Intervention:  
Sponsors:   Zhujiang Hospital;   Guangdong Province, Department of Science and Technology
Recruiting - verified July 2016

Safety and Efficacy Study of a Protease Activated Receptor-4 Antagonist Being Tested to Reduce the Chances of Having Additional Strokes or "Mini Strokes"

Condition:   Thrombosis
Interventions:   Drug: BMS-986141;   Drug: Aspirin;   Other: Placebo
Sponsor:   Bristol-Myers Squibb
Recruiting - verified July 2016

Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Subjects With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)

Conditions:   Anemia;   Non-dialysis-dependent Chronic Kidney Disease
Interventions:   Drug: vadadustat;   Drug: darbepoetin alfa
Sponsor:   Akebia Therapeutics
Recruiting - verified July 2016

Fractional FLow Reserve And IVUS for Clinical OUtcomes in Patients With InteRmediate Stenosis

Condition:   Stable Angina
Intervention:   Device: Drug-eluting stent
Sponsors:   Seoul National University Hospital;   Ajou University School of Medicine;   Keimyung University Dongsan Medical Center;   Inje University
Recruiting - verified July 2016

Biofeedback to Increase Propulsion During Walking After Stroke

Condition:   Stroke
Interventions:   Procedure: Gait Training with Biofeedback;   Procedure: Gait Training with Verbal Feedback
Sponsor:   VA Office of Research and Development
Not yet recruiting - verified July 2016

Efficacy and Safety Study to Evaluate Vadadustat for the Correction of Anemia in Subjects With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)

Conditions:   Anemia;   Non-dialysis-dependent Chronic Kidney Disease
Interventions:   Drug: vadadustat;   Drug: darbepoetin alfa
Sponsor:   Akebia Therapeutics
Recruiting - verified July 2016

Robotic Training for Stroke Neurorehabilitation

Condition:   Stroke
Interventions:   Device: Robotic Therapy;   Other: Conventional Therapy
Sponsor:   VA Office of Research and Development
Not yet recruiting - verified July 2016

Remote Ischaemic Conditioning and Coronary Endothelial Function (RIC-COR)

Conditions:   Ischemic Preconditioning;   Coronary Disease
Interventions:   Procedure: Remote ischaemic conditioning;   Procedure: Arm cuff placement, no inflation;
Sponsors:   NHS National Waiting Times Centre Board;   University of Glasgow;   Chest, Heart and Stroke Association Scotland;   Chief Scientist Office of the Scottish Government
Completed - verified July 2016

Multicenter Prospective Cohort of Informal Caregivers in Burgundy and Franche-Comté

Conditions:   Breast Cancer;   Colorectal Cancer;   Prostate Cancer;   Alzheimer Disease;   Age-related Macular Degeneration;   Parkinson Disease;   Cardiac Disease;   Ischemic Stroke;   Hemorrhagic Stroke
Interventions:   Behavioral: Support provided by social worker;   Other: Information booklet receipt
Sponsors:   Centre Hospitalier Universitaire de Besancon;   Methodological and quality of life unit in oncology (CHRU de Besançon);   University of Franche-Comté;   University of Burgundy;   Pôle de Gérontologie Interrégional Bourgogne et Franche-Comté;   CARSAT Bourgogne et Franche-Comté;   CCAS of Dijon;   CCAS of Besançon;   CCAS of Montbéliard;   Burgundy Regional Council;   Franche-Comté Regional Council;   The Municipality of Besançon;   The Municipality of Dijon;   General Council of the Doubs;   General Council of the Territoire de Belfort;   Collectif Inter Associatif Sur la Sante Bourgogne;   Union Régionale Interfédérale des Œuvres et Organismes Privés Sanitaires Bourgogne;   Association Gérontopôle Pierre Pfitzenmeyer;   Pôle de compétitivité Vitagora Goût-Nutrition-Santé;   Caisse Nationale d’Assurance Vieillesse des Travailleurs Salariés (CNAVTS);   Sheerbrooke Gérontopôle;   France Alzheimer Côte-d’Or;   Institut Régional de Vieillissement (IRV);   Novartis Pharmaceuticals;   Roche Foundation;   Ligue contre le cancer, France;   National Cancer Institute, France;   Quality of life and cancer clinical research platform
Recruiting - verified July 2016

Patient Convenience Study (RE-SONANCE)

Conditions:   Atrial Fibrillation;   Stroke
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified July 2016

Observational Study of Hemiplegic Shoulder Pain After Recent Stroke

Conditions:   Shoulder Pain;   Hemiplegia;   Stroke
Interventions:   Other: ShoulderQ which is a shoulder pain questionnaire;   Other: Clinical shoulder examination
Sponsor:   St George's, University of London
Recruiting - verified July 2016

Special Drug Use Investigation of Xarelto for Venous Thromboembolism (VTE)

Condition:   Venous Thromboembolism
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified July 2016

Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa II

Conditions:   Sickle Cell Disease;   Stroke
Interventions:   Drug: Hydroxyurea (Moderate Dose);   Drug: Hydroxyurea (Low Dose)
Sponsors:   Vanderbilt University;   Aminu Kano Teaching Hospital;   Murtala Muhammed Specialist Hospital;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 2016

Global Study Comparing a rivAroxaban-based Antithrombotic Strategy to an antipLatelet-based Strategy After Transcatheter aortIc vaLve rEplacement to Optimize Clinical Outcomes

Condition:   Transcatheter Aortic Valve Replacement
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Acetylsalicylic acid;   Drug: Clopidogrel
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting - verified July 2016

Epidemiological Study on the Safety of Aspirin in The Health Improvement Network (THIN)

Conditions:   Secondary Prevention;   Stroke;   Ischemic Heart Disease;   Coronary Heart Disease
Interventions:   Drug: Acetylsalicylic Acid (Asprin, BAYE4465);   Drug: Clopidogrel, Oral Anticoagulants, NSAIDs and SSRIs
Sponsor:   Bayer
Recruiting - verified July 2016

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified July 2016

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified July 2016

Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection

Conditions:   HIV Infections;   Neurologic Disorders
Intervention:   Drug: Anakinra
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Johns Hopkins University
Enrolling by invitation - verified June 2016

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Recruiting - verified July 2016

Mobile Phones in Cryptogenic Stroke Patients Bringing Single Lead ECGs to Detect Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Ischemic Stroke;   Transient Ischemic Attack
Interventions:   Device: Single lead ECG device;   Device: 7-Day Holter monitor.
Sponsors:   Leiden University Medical Center;   Medical Center Haaglanden;   Groene Hart Ziekenhuis;   Herning Hospital;   Bronovo Hospital
Recruiting - verified July 2016

ARISE: After 8 Hours Reperfusion in Ischemic Stroke Embolization

Condition:   Ischemic Stroke
Intervention:   Device: mechanical thrombectomy
Sponsor:   Abington Memorial Hospital
Recruiting - verified July 2016

Prevalence of Resistant Hypertension With DOT

Condition:   Hypertension
Intervention:   Procedure: Direct Observed Therapy test
Sponsor:   Ottawa Hospital Research Institute
Recruiting - verified July 2016

Comparison Between Thoracoscopic Left Atrial Appendage Excision and Warfarin for the Secondary Prevention of Stroke in Patients With AF

Conditions:   Atrial Fibrillation;   Stroke;   Systemic Embolism
Interventions:   Procedure: Thoracoscopic Left Atrial Appendage Excision;   Drug: Warfarin
Sponsor:   The First Affiliated Hospital with Nanjing Medical University
Recruiting - verified July 2016

Real Evidence of Anticoagulation Treatment in Non-valvular Atrial Fibrillation in Germany, UK and France: REACT-AF2

Condition:   Non-valvular Atrial Fibrillation
Intervention:  
Sponsors:   Bristol-Myers Squibb;   IMS Health;   Oxon Epidemiology
Active, not recruiting - verified July 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsor:   Bayer
Recruiting - verified July 2016

Noninvasive Brain Stimulation to Evaluate Neural Plasticity After Stroke

Condition:   Cerebrovascular Stroke
Interventions:   Device: Transcranial Magnetic Stimulation (Magstim);   Device: Traditional Paired Associative Stimulation;   Device: Median Nerve Stimulation;   Device: Corticocortical Paired Associative Stimulation;   Device: Sham Paired Associative Stimulation
Sponsor:   Emory University
Recruiting - verified July 2016

Amplatzer™Amulet™ Post-Market Study

Conditions:   Atrial Fibrillation;   Thromboembolism;   Stroke
Intervention:   Device: Subjects implanted with Amulet Device
Sponsor:   St. Jude Medical
Recruiting - verified July 2016

Cardiac Performance in Pregnant Obese Women:Are They in Jeopardy?

Condition:   Cardiac Performance
Intervention:   Other: echocardiogram
Sponsors:   Benha University;   Armed Forces Hospital, Southern Region, Khamis Mushayt, Saudi Arabia
Active, not recruiting - verified January 2016

Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension

Condition:   Hypertension
Interventions:   Drug: Trimethaphan;   Drug: Nitroglycerin
Sponsor:   Vanderbilt University
Recruiting - verified July 2016

Vascular Ultrasound Screening in Patients With Ischemic Cerebrovascular Disease: a Multi-center Registry Study

Condition:   Stroke
Intervention:  
Sponsors:   Xuanwu Hospital, Beijing;   The First Affiliated Hospital of Shanxi Medical University;   Liaocheng Brains Hospital;   Tianjin Huanhu Hospital;   Baotou City Central Hospital;   First Hospital of Jilin University;   First Affiliated Hospital of Harbin Medical University;   First Hospital of China Medical University;   LanZhou University;   First Affiliated Hospital of Xinjiang Medical University;   The First Affiliated Hospital of Soochow University;   Anhui Provincial Hospital;   Guangdong Provincial Hospital of Traditional Chinese Medicine;   ZhuHai Hospital;   Fujian Provincial Hospital;   Mianyang Central Hospital;   The Second Affiliated Hospital of Kunming Medical University;   Brains Hospital of Hunan Province;   Henan Provincial Hospital;   Luoyang Central Hospital;   National Health and Family Planning Commission Stroke Prevention Engineering Committee;   Dalian Municipal Central Hospital
Completed - verified July 2016

Preconditioning With Limb Ischemia for Subarachnoid Hemorrhage

Condition:   Ischemic Preconditioning
Intervention:   Other: ischemic conditioning group
Sponsor:   University of Miami
Recruiting - verified July 2016

Neuroprotection in Patients Undergoing Aortic Valve Replacement

Conditions:   Aortic Stenosis;   Brain Infarction;   Cerebrovascular Accident;   Stroke
Interventions:   Device: Embol-X Embolic Protection Device;   Device: CardioGard Cannula
Sponsors:   Icahn School of Medicine at Mount Sinai;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified July 2016

Patients With Patent Foramen Ovale and Endocardial Device Leads on Apixaban for Prevention of Paradoxical Emboli

Conditions:   Patent Foramen Ovale;   Cardiac Implantable Electronic Device
Interventions:   Drug: Apixaban;   Drug: Placebo
Sponsors:   Mayo Clinic;   Bristol-Myers Squibb
Withdrawn - verified July 2016

Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy

Conditions:   Giant Axonal Neuropathy;   Gene Transfer
Intervention:   Drug: Intrathecal Delivery of scAAV9/JeT-GAN
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 2016

Weight Loss Referral for Healthier Survivorship in Obese Stage I-II Endometrial Cancer Survivors or Atypical Hyperplasia

Conditions:   Complex Endometrial Hyperplasia With Atypia;   Stage IA Uterine Corpus Cancer;   Stage IB Uterine Corpus Cancer;   Stage II Uterine Corpus Cancer
Interventions:   Behavioral: Weight Loss Specialist;   Other: Quality-of-Life Assessment;   Other: Medical Chart Review
Sponsors:   Case Comprehensive Cancer Center;   National Cancer Institute (NCI)
Active, not recruiting - verified July 2016

Role of PPAR-y Agonists in Immunomodulation and Vascular Prevention in SLE (PPAR-SLE)

Condition:   Systemic Lupus Erthematosus
Interventions:   Radiation: PET/CT;   Drug: Pioglitazone;   Procedure: Vascular function studies
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified February 2016

Timing of Coronary Angiography, Cardiac Surgery, and Adverse Renal and Cardiac Events (MARCE)

Conditions:   Acute Kidney Injury;   Renal Insufficiency
Intervention:   Procedure: cardiac surgery
Sponsor:   Baylor Research Institute
Active, not recruiting - verified July 2016

Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)

Condition:   Stroke
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin (Acetylsalicylic acid, BAY1019036);   Other: Rivaroxaban-Placebo;   Other: Aspirin-Placebo
Sponsors:   Bayer;   Janssen, LP;   Hamilton Health Sciences Cooperation, Population Health Research Institute
Recruiting - verified July 2016

Evaluation of Minimally Invasive Subcortical Parafascicular Access for Clot Evacuation

Condition:   Cerebral Hemorrhage
Intervention:  
Sponsor:   Amin B Kassam
Recruiting - verified July 2016

Combined Coronary and Cerebral Angiography and Intervention for Coronary and Cerebrovascular Atherosclerosis

Conditions:   Coronary Stenosis;   Cerebral Stenosis
Interventions:   Other: simultaneous coronary and cerebral intervention;   Other: staged coronary and cerebral intervention
Sponsor:   Capital Medical University
Recruiting - verified July 2016

Adjunctive Neurovascular Support for Wide-neck Aneurysm Embolization and Reconstruction

Condition:   Intracranial Aneurysms
Intervention:   Device: PulseRider
Sponsor:   Pulsar Vascular
Active, not recruiting - verified July 2016

Virtual Reality Exercise for Stroke Rehabilitation in Inpatients Who Are Unable to Stand

Condition:   Stroke
Interventions:   Other: virtual reality training;   Other: control
Sponsors:   Bruyere Research Institute;   Ottawa Hospital Research Institute;   University of Ottawa;   Heart and Stroke Foundation of Canada
Recruiting - verified July 2016

Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability

Conditions:   Chronic Troublesome Sialorrhea;   Cerebral Palsy;   Stroke;   Traumatic Brain Injury;   Intellectual Disability
Interventions:   Drug: IncobotulinumtoxinA;   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Recruiting - verified July 2016

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified July 2016

Decompressive Hemicraniectomy in Intracerebral Hemorrhage

Condition:   Cerebral Hemorrhage
Interventions:   Procedure: Decompressive craniectomy (DC) and best medical treatment;   Procedure: Best medical treatment
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified May 2016

Drug Persistence/Adherence in Patients Treated With Dabigatran or VKA for Stroke Prevention in Non Valvular Atrial Fibrillation (SPAF)

Condition:   Atrial Fibrillation
Interventions:   Drug: Dabigatran etexilate;   Drug: Phenprocoumon
Sponsor:   Boehringer Ingelheim
Recruiting - verified July 2016

AOP2014 in Patients With Polycythemia Vera Who Previously Participated in the PROUD-PV Study.

Condition:   Polycythemia Vera
Intervention:   Drug: Pegylated-Proline-interferon alpha-2b
Sponsors:   AOP Orphan Pharmaceuticals AG;   PharmaEssentia (Co-Sponsor for USA)
Active, not recruiting - verified July 2016

Intra-arterial Bone-marrow Mononuclear Cells Infusion for Acute Ischemic Stroke

Condition:   Ischemic Stroke
Intervention:   Drug: Autologous bone marrow mononuclear cell intra-arterial injection
Sponsor:   Andalusian Initiative for Advanced Therapies
Recruiting - verified July 2016

Efficacy of Isradipine in Early Parkinson Disease

Condition:   Parkinson Disease
Interventions:   Drug: Isradipine;   Drug: Placebo (for Isradipine)
Sponsors:   University of Rochester;   National Institute of Neurological Disorders and Stroke (NINDS);   Michael J. Fox Foundation for Parkinson's Research;   The Parkinson Study Group
Active, not recruiting - verified July 2016

3D Multi-Contrast Atherosclerosis Characterization of the Carotid Artery

Condition:   Carotid Artery Disease
Intervention:   Other: MRI with/without contrast
Sponsors:   Cedars-Sinai Medical Center;   National Heart, Lung, and Blood Institute (NHLBI);   American Heart Association
Recruiting - verified July 2016

Rate Control Versus Rhythm Control For Postoperative Atrial Fibrillation

Condition:   Postoperative Atrial Fibrillation
Interventions:   Drug: Amiodarone;   Procedure: DC-cardioversion;   Drug: Rate Control
Sponsors:   Icahn School of Medicine at Mount Sinai;   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Neurological Disorders and Stroke (NINDS);   Canadian Institutes of Health Research (CIHR)
Completed - verified July 2016

ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea.

Conditions:   Heart Failure;   Obstructive Sleep Apnea;   Central Sleep Apnea
Intervention:   Other: [C11]Acetate and HED PET
Sponsor:   Ottawa Heart Institute Research Corporation
Recruiting - verified July 2016

Metabolic Costs of Walking Post Stroke

Condition:   Acute Stroke
Interventions:   Other: ESTT;   Other: Traditional outpatient
Sponsor:   University of Texas Southwestern Medical Center
Active, not recruiting - verified July 2016

A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients

Conditions:   Heart Failure;   Respiratory Insufficiency;   Stroke Acute;   Infectious Diseases;   Rheumatic Diseases
Interventions:   Drug: Rivaroxaban, 10 mg;   Drug: Rivaroxaban, 7.5 mg;   Drug: Placebo
Sponsor:   Janssen Research & Development, LLC
Recruiting - verified July 2016

Swiss Atrial Fibrillation Cohort Study

Condition:   Atrial Fibrillation
Intervention:  
Sponsors:   University Hospital, Basel, Switzerland;   Swiss National Science Foundation;   Medical Image Analysis Center (MIAC) Basel;   Schiller AG Baar;   Clinical Trial Unit, University Hospital Basel, Switzerland;   Cardiovascular Research Institute (CRIB) Basel;   Cardiocentro Ticino
Recruiting - verified July 2016

Adolescent Master Protocol for Participants 18 Years of Age and Older (AMP Up)

Condition:   HIV/AIDS
Intervention:  
Sponsors:   Harvard School of Public Health;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute on Drug Abuse (NIDA);   National Institute of Allergy and Infectious Diseases (NIAID);   NIH Office of AIDS Research (OAR);   National Institute of Mental Health (NIMH);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Deafness and Other Communication Disorders (NIDCD);   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Dental and Craniofacial Research (NIDCR);   National Institute on Alcohol Abuse and Alcoholism (NIAAA);   Tulane University School of Medicine
Recruiting - verified July 2016

Emotional Communication Disorders in Cerebellar Disease

Condition:   Cerebellar Diseases
Interventions:   Behavioral: Testing of emotional communication ability;   Procedure: magnetic resonance imaging (MRI) of the brain
Sponsors:   University of Florida;   National Institute on Aging (NIA)
Recruiting - verified July 2016

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy;   Device: Carotid stenting
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 2016

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Conditions:   Hypertension;   Cardiovascular Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting - verified July 2016

Rivaroxaban Versus Warfarin in Acute Ischemic Stroke With Atrial Fibrillation

Conditions:   Ischemic Stroke;   Transient Ischemic Attack
Interventions:   Drug: Rivaroxaban;   Drug: Warfarin
Sponsors:   Asan Medical Center;   Bayer
Completed - verified July 2016

Rehabilitation of Attention in Patients With MCI and Brain Subcortical Vascular Changes Using the APT-II

Condition:   Mild Cognitive Impairment
Intervention:   Behavioral: Attention Process Training-II
Sponsors:   Azienda Ospedaliero-Universitaria Careggi;   Ministero della Salute, Italy
Completed - verified July 2016

Verification of the Safety of Early Discharge in Patients After Acute ST-segment Myocardial Infarction

Conditions:   Coronary Artery Disease;   Acute Myocardial Infarction With ST-segment Elevation;   Primary Percutaneous Coronary Intervention;   Early Discharge
Interventions:   Other: Early discharge;   Other: Standard discharge
Sponsor:   Kamil Novobílský
Recruiting - verified July 2016

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified July 2016

Cognitive Changes and Rehabilitation in People With Transient Ischemic Attack, Stroke, or Stroke Risk Factors

Conditions:   Ischemic White Matter Disease;   Transient Ischemic Attack;   Mild Stroke;   Stroke Risk
Interventions:   Behavioral: Executive Function Training Program;   Behavioral: Psychoeducational Training Program
Sponsors:   Baycrest;   Sunnybrook Health Sciences Centre
Recruiting - verified July 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Germany)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsor:   Bayer
Recruiting - verified July 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxoban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsor:   Bayer
Recruiting - verified July 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)

Condition:   Pulmonary Embolism
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Warfarin
Sponsor:   Bayer
Recruiting - verified July 2016

Impact of RBC Transfusion Less Than 14 Days on Morbidity and Mortality in Cardiac Surgical Patients

Conditions:   Postoperative; Dysfunction Following Cardiac Surgery;   Transfusion Related Complication
Intervention:   Procedure: study population
Sponsor:   Centre Hospitalier Universitaire de Besancon
Terminated - verified August 2013

ENDOvascular Interventions With AngioMAX: The ENDOMAX Trial

Condition:   Peripheral Endovascular Interventions
Intervention:   Drug: Bivalirudin
Sponsor:   The Medicines Company
Active, not recruiting - verified July 2016

Cortical Recording and Stimulating Array Brain-Machine Interface

Conditions:   Tetraplegia;   Spinal Cord Injury;   Brainstem Stroke
Intervention:   Device: Implantation of CRS Arrays in the motor cortex and sensory cortex of the brain
Sponsors:   University of Pittsburgh;   Defense Advanced Research Projects Agency;   United States Department of Defense;   Johns Hopkins University
Recruiting - verified July 2016

Eliquis Regulatory Post Marketing Surveillance

Condition:   NonValvular Atrial Fibrillation
Intervention:   Drug: Apixaban
Sponsor:   Bristol-Myers Squibb
Recruiting - verified July 2016

Early Versus Emergency Left Ventricular Assist Device Implantation in Patients Awaiting Cardiac Transplantation

Condition:   End Stage Heart Disease
Intervention:   Device: Early VAD implantation
Sponsors:   German Heart Institute;   Deutsches Zentrum für Herz-Kreislauf-Forschung;   Helmholtz Zentrum München;   Universitätsmedizin Greifswald;   Universitätsmedizin Göttingen
Recruiting - verified July 2016

OPtical Frequency Domain Imaging vs. INtravascular Ultrasound in Percutaneous Coronary InterventiON

Condition:   Coronary Artery Disease
Interventions:   Device: OFDI;   Device: IVUS
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Wakayama Medical University
Completed - verified July 2016

Study Of Diabetic Nephropathy With Atrasentan

Condition:   Diabetic Nephropathy
Interventions:   Drug: Atrasentan;   Drug: Placebo
Sponsor:   AbbVie
Recruiting - verified July 2016

Safety and Efficacy of TCD-10023 (Ultimaster) Drug-eluting Stent in STEMI Patients - MASTER Study

Condition:   Acute ST Segment Elevation Myocardial Infarction
Interventions:   Device: PCI in patients with ST-elevation myocardial infarction;   Device: PCI in patients with ST-elevation myocardial infarction
Sponsor:   Terumo Europe N.V.
Active, not recruiting - verified July 2016

Exploring the Efficacy of Once Daily Oral Rivaroxaban for Treatment of Thrombus in Left Atrial/Left Atrial Appendage in Subjects With Nonvalvular Atrial Fibrillation or Atrial Flutter

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Completed - verified December 2015

Sickle Cell Disease - Stroke Prevention in Nigeria Trial

Conditions:   Sickle Cell Anemia;   Sickle Cell Disease;   Stroke
Intervention:   Drug: Hydroxyurea
Sponsors:   Vanderbilt University;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   Aminu Kano Teaching Hospital
Active, not recruiting - verified July 2016

Health Promotion and Wellness Program for Stroke Survivors

Condition:   Stroke
Interventions:   Behavioral: SystemCHANGE Group Lifestyle counseling;   Behavioral: Phone Lifestyle Counseling
Sponsors:   Case Western Reserve University;   American Heart Association
Recruiting - verified July 2016

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention &Amp; Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute
Recruiting - verified July 2016

SPARK: Safety Study of Pradaxa in Atrial Fibrillation Patients by Regulatory Requirement of Korea

Condition:   Atrial Fibrillation
Intervention:   Drug: Pradaxa (Dabigatran etexilate mesilate)
Sponsor:   Boehringer Ingelheim
Recruiting - verified July 2016

Fractional Flow Reserve Versus Angiographically Guided Management to Optimise Outcomes in Unstable Coronary Syndromes

Conditions:   Non-ST Elevation Myocardial Infarction.;   Type 1 Myocardial Infarction.
Intervention:   Device: Fractional flow reserve
Sponsors:   NHS National Waiting Times Centre Board;   British Heart Foundation;   St. Jude Medical;   University of Glasgow
Active, not recruiting - verified July 2016

Intensive Motor Training After Perinatal Stroke to Enhance Walking

Condition:   Perinatal Stroke
Interventions:   Behavioral: Early leg training;   Behavioral: Delayed leg training
Sponsors:   University of Alberta;   Alberta Innovates Health Solutions
Recruiting - verified July 2016

Continued Access to PREVAIL (CAP2)

Condition:   Atrial Fibrillation
Intervention:   Device: WATCHMAN LAA Closure Technology
Sponsor:   Boston Scientific Corporation
Active, not recruiting - verified July 2016

VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL

Conditions:   Depression;   Depressive Symptoms;   Mood
Interventions:   Dietary Supplement: vitamin D3;   Drug: omega-3 fatty acids (fish oil);   Dietary Supplement: Fish oil placebo;   Dietary Supplement: Vitamin D placebo
Sponsors:   Brigham and Women's Hospital;   National Institute of Mental Health (NIMH)
Active, not recruiting - verified July 2016

A Study of Evacetrapib in High-Risk Vascular Disease

Condition:   Cardiovascular Diseases
Interventions:   Drug: Evacetrapib;   Drug: Placebo
Sponsors:   Eli Lilly and Company;   The Cleveland Clinic
Active, not recruiting - verified July 2016

Strategy of Continued Versus Interrupted Novel Oral Anti-coagulant at Time of Device Surgery in Patients With Moderate to High Risk of Arterial Thromboembolic Events

Condition:   Hematoma
Interventions:   Drug: Dabigatran;   Drug: Rivaroxaban;   Drug: Apixaban
Sponsors:   Ottawa Heart Institute Research Corporation;   Boehringer Ingelheim;   Heart and Stroke Foundation of Canada
Recruiting - verified July 2016

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab;   Drug: Placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified July 2016

Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02)

Conditions:   Carotid Stenosis;   Atherosclerosis;   Stroke;   Transient-ischaemic Attack;   TIA;   Amaurosis Fugax
Interventions:   Drug: Revacept;   Drug: Placebo
Sponsor:   AdvanceCor GmbH
Recruiting - verified July 2016

Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsor:   Bayer
Completed - verified May 2016

Relating Genetic and Environmental Risk Scores to Multiple Sclerosis Susceptibility

Condition:   Multiple Sclerosis
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified June 2016

BOTOX® Treatment in Pediatric Upper Limb Spasticity

Conditions:   Pediatrics;   Muscle Spasticity;   Cerebral Palsy;   Stroke
Interventions:   Biological: botulinum toxin Type A;   Biological: botulinum toxin Type A;   Drug: Normal Saline (Placebo)
Sponsor:   Allergan
Recruiting - verified July 2016

BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity

Conditions:   Pediatrics;   Muscle Spasticity;   Cerebral Palsy;   Stroke
Intervention:   Biological: botulinum toxin Type A
Sponsor:   Allergan
Recruiting - verified July 2016

PRevention of End Stage Kidney Disease by Darbepoetin Alfa In Chronic Kidney Disease Patients With nondiabeTic Kidney Disease

Conditions:   Chronic Kidney Disease;   Diabetes
Intervention:   Drug: Darbepoetin alfa
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Showa University School of Medicine
Active, not recruiting - verified July 2016

Xarelto [SPAF-QOL] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban (Xarelto_ BAY59-7939)
Sponsor:   Bayer
Active, not recruiting - verified July 2016

Studying Motor Neuron Tests

Conditions:   Magnetic Resonance Imaging;   Central Nervous System;   Volunteer;   Neurological Disorder
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 2016

Motor Cortex Stimulation for Chronic Neuropathic Pain

Conditions:   Neuropathic Pain;   Facial Pain;   Post-stroke Pain;   Brachial Plexus Avulsion;   Phantom Limb Pain of the Upper Extremities
Intervention:   Device: Motor Cortex Stimulation using SJM EonC Stimulator
Sponsor:   St. Jude Medical
Recruiting - verified July 2016

Hyper-CVAD and Ponatinib in Ph-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia (ALL)

Condition:   Leukemia
Interventions:   Drug: Cyclophosphamide;   Drug: Mesna;   Drug: Doxorubicin;   Drug: Vincristine;   Drug: Dexamethasone;   Drug: Ponatinib;   Drug: G-CSF (Filgrastim);   Drug: Rituximab;   Drug: Methotrexate;   Drug: Cytarabine;   Drug: Solu-medrol ( Methyl Prednisolone);   Drug: Citrovorum (Leucovorin);   Drug: Prednisone;   Drug: Pegfilgrastim (Neulasta)
Sponsors:   M.D. Anderson Cancer Center;   Ariad Pharmaceuticals
Active, not recruiting - verified July 2016

ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis

Conditions:   Tetraplegia;   Spinal Cord Injury;   Brachial Plexus Injury;   Muscular Dystrophy;   ALS;   Brainstem Stroke
Intervention:   Device: Implantation of ECoG sensors on the brain surface
Sponsor:   University of Pittsburgh
Completed - verified July 2016

Adolescent Master Protocol

Condition:   HIV/AIDS
Intervention:  
Sponsors:   Harvard School of Public Health;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute on Drug Abuse (NIDA);   National Institute of Allergy and Infectious Diseases (NIAID);   National Institute of Mental Health (NIMH);   National Heart, Lung, and Blood Institute (NHLBI);   National Institute on Deafness and Other Communication Disorders (NIDCD);   National Institute on Alcohol Abuse and Alcoholism (NIAAA);   National Institute of Neurological Disorders and Stroke (NINDS);   Tulane University School of Medicine;   National Institute of Dental and Craniofacial Research (NIDCR);   NIH Office of AIDS Research (OAR)
Active, not recruiting - verified July 2016

Microelectrode Brain-Machine Interface for Individuals With Tetraplegia

Conditions:   Tetraplegia;   Spinal Cord Injury
Intervention:   Device: Implantation of NeuroPort Arrays in the motor cortex
Sponsors:   University of Pittsburgh;   United States Department of Defense;   Johns Hopkins University
Recruiting - verified July 2016

Interval Training and Resting Metabolism

Condition:   Healthy Subjects
Interventions:   Behavioral: 1 x 4 minute interval;   Behavioral: 4 x 4 minutes Intervals;   Behavioral: Moderate continuous Training
Sponsors:   Norwegian University of Science and Technology;   St. Olavs Hospital
Completed - verified July 2016

EXCEL Clinical Trial

Conditions:   Chronic Coronary Occlusion;   Unprotected Left Main Coronary Artery Disease;   Stent Thrombosis;   Vascular Disease;   Myocardial Ischemia;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Artery Disease;   Coronary Restenosis
Interventions:   Device: Percutaneous Coronary Intervention;   Procedure: CABG
Sponsor:   Abbott Vascular
Active, not recruiting - verified July 2016

A Phase I Trial of Safety and Immunogenicity of Gardasil Vaccination Post Stem Cell Transplantation in Patients With and Without Immunosuppression

Conditions:   Gardasil Vaccine;   Stem Cell Transplant;   Immunogenicity
Intervention:   Biological: Gardasil
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed - verified September 2015

Post-authorization Safety Study of Etoricoxib and Other Anti-inflammatory Therapies in European Patients With Ankylosing Spondylitis (MK-0663-163)

Condition:   Ankylosing Spondylitis
Intervention:  
Sponsor:   Merck Sharp & Dohme Corp.
Active, not recruiting - verified July 2016

A Study With Aleglitazar in Patients With a Recent Acute Coronary Syndrome and Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus Type 2
Interventions:   Drug: Aleglitazar;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Completed - verified July 2016

Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial

Condition:   Ischemic Attack, Transient
Interventions:   Drug: Clopidogrel;   Drug: placebo
Sponsors:   University of California, San Francisco;   Neurological Emergencies Treatment Trials Network (NETT);   Medical University of South Carolina;   The EMMES Corporation
Recruiting - verified July 2016

The Clinical Evaluation of the Dose of Erythropoietins Trial

Condition:   Kidney Failure, Chronic
Interventions:   Drug: Erythropoiesis Stimulating Agents (ESAs): epoetin alfa, beta or any other epoetin in equivalent dose.;   Drug: Erythropoiesis Stimulating Agents (ESAs): epoetin alfa, beta or any other epoetin in equivalent dose.
Sponsor:   Giovanni FM Strippoli, MD
Completed - verified July 2016

CPAP Therapy in Patients With Heart Failure and Obstructive Sleep Apnea.

Conditions:   Heart Failure;   Obstructive Sleep Apnea
Interventions:   Other: Positron Emission Tomography;   Other: Positron Emission Tomography;   Other: Positron Emission Tomography
Sponsors:   Ottawa Heart Institute Research Corporation;   Heart and Stroke Foundation of Ontario
Completed - verified July 2016

The Melatonin Adjunct in the Acute myocaRdial Infarction Treated With Angioplasty

Condition:   Acute Myocardial Infarction
Intervention:   Drug: melatonin
Sponsor:   Alberto Domínguez Rodríguez
Terminated - verified July 2016

Defining Strategies for Improving Endothelial and Fibrinolytic Dysfunction in Obesity

Condition:   Metabolic Syndrome X
Interventions:   Drug: Eplerenone;   Drug: Ramipril
Sponsor:   Vanderbilt University
Terminated - verified July 2016

PFO ACCESS Registry

Conditions:   Patent Foramen Ovale;   Stroke
Intervention:   Device: Device closure with the AMPLATZER PFO Occluder
Sponsor:   St. Jude Medical
Available - verified July 2016

Relative Risks for Non-fatal Venous Thromboembolism, Ischemic Stroke and Myocardial Infarction in Users of ORTHO EVRA(Norelgestromin and Ethinyl Estradiol Contraceptive Patch) Compared to Levonorgestrel-containing Oral Contraceptives.

Conditions:   Contraception;   Female Contraception;   Fertility Control
Intervention:  
Sponsors:   Johnson & Johnson Pharmaceutical Research & Development, L.L.C.;   Boston Collaborative Drug Surveillance Program
Completed - verified July 2016

RESPECT PFO Clinical Trial

Condition:   Cryptogenic Stroke
Interventions:   Device: AMPLATZER PFO Occluder;   Other: Standard of Care - Medical Management
Sponsor:   St. Jude Medical
Active, not recruiting - verified July 2016

PET and Recovery Following Revascularization (PARR 2)

Conditions:   Coronary Artery Disease;   Ventricular Dysfunction, Left
Interventions:   Procedure: Positron emission tomography: FDG viability imaging;   Other: PET imaging
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research (CIHR);   Heart and Stroke Foundation of Ontario
Completed - verified July 2016

A Postmarketing Study of the Risk of Venous Thromboembolism (Blood Clots), Myocardial Infarction (Heart Attacks), and Stroke Among Women Using ORTHO EVRA (Norelgestromin and Ethinyl Estradiol Contraceptive Patch) Compared With Women Who Take Oral Contraceptives for Birth Control

Conditions:   Contraception;   Female Contraception
Interventions:   Drug: Transdermal Contraceptive System;   Drug: Norgestimate-containing oral contraceptives with EE
Sponsor:   Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Completed - verified July 2016

Cardiology Biobank Registry

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   Emory University
Recruiting - verified July 2016

Genetic Factors in Atherosclerosis

Condition:   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Completed - verified March 2013

Vision Testing in Patients With Partial Seizures Receiving Either Lyrica or Placebo

Condition:   Epilepsies, Partial
Interventions:   Drug: Lyrica (pregabalin);   Drug: placebo
Sponsor:   Pfizer
Recruiting - verified July 2016

Postmarketing Study of ORTHO EVRA (Norelgestromin and Ethinyl Estradiol Contraceptive Patch) in Relation to Venous Thromboembolism (Blood Clots), Stroke and Heart Attacks

Conditions:   Contraception;   Female Contraception
Interventions:   Drug: Monophasic or triphasic Oral contraceptive tablet;   Drug: Ortho Evra transdermal patch containing 6 mg NGMN/0.75 mg EE
Sponsors:   Johnson & Johnson Pharmaceutical Research & Development, L.L.C.;   Boston Collaborative Drug Surveillance Program
Completed - verified July 2016

Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients

Condition:   Angina Pectoris
Interventions:   Behavioral: Hypoxic interval training;   Behavioral: Normoxic interval training
Sponsors:   Norwegian University of Science and Technology;   Aarhus University Hospital
Completed - verified July 2016

Relatively Healthy Male Veterans Observed Over Time to See What Types of Diseases Develop

Condition:   Healthy
Intervention:  
Sponsor:   VA Office of Research and Development
Active, not recruiting - verified July 2016

Pelvic Pain in Women With Endometriosis

Conditions:   Endometriosis;   Pelvic Pain;   Healthy;   Tubal Ligation
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed - verified June 2016

Safety Study of AVP-923 in the Treatment of IEED (Involuntary Emotional Expression Disorder) Also Known as Pseudobulbar Affect (Episodes of Uncontrolled Crying and/or Laughter)

Conditions:   Alzheimer's Disease;   Stroke;   Parkinson's Disease;   Traumatic Brain Injury
Intervention:   Drug: AVP-923
Sponsor:   Avanir Pharmaceuticals
Completed - verified July 2016

Effects of Treating Obstructive Sleep Apnea in Epilepsy

Conditions:   Epilepsy;   Sleep Apnea;   Obstructive Sleep Apnea
Interventions:   Device: continuous positive airway pressure (CPAP);   Device: Placebo-CPAP
Sponsors:   Vanderbilt University;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified July 2016

Pediatrics:Chlamydia, Sickle Cell Anemia and Stroke Risk - Ancillary to STOP II

Conditions:   Blood Disease;   Anemia, Sickle Cell;   Chlamydia Infections;   Cerebrovascular Accident
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

Screening and Natural History: Primary Lateral Sclerosis and Related Disorders

Condition:   Primary Lateral Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified July 2016

Evaluation of Patients With HAM/TSP

Conditions:   HTLV-I Infection;   Tropical Spastic Paraparesis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 2016

Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

Condition:   Multiple Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 2016