Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Mild Hypothermia After Endovascular Treatment in Acute Ischemic Stroke

Conditions:   Ischemic Stroke;   Thrombolytic Therapy
Interventions:   Device: Arctic Sun;   Other: Standard treatment;   Drug: Saline
Sponsors:   Seoul National University Hospital;   Bard Medical Division C.R. Bard Inc
Recruiting - verified December 2016

Wide Spectrum Investigation of Stroke Outcome Disparities on Multiple Levels (WISSDOM)

Condition:   Stroke
Intervention:   Behavioral: Community-based Intervention under Nurse Guidance after Stroke
Sponsors:   Medical University of South Carolina;   American Heart Association
Recruiting - verified September 2016

Implementation of Clinical Pathway to Improve Quality of Healthcare in Stroke Inpatients

Condition:   Stroke
Intervention:  
Sponsor:   Changhua Christian Hospital
Not yet recruiting - verified November 2016

Pupillometry in Horner's Syndrome

Conditions:   Horner's Syndrome;   Stroke;   Dissection Carotid Artery
Intervention:   Device: Automated pupillometry
Sponsor:   University of Zurich
Not yet recruiting - verified November 2016

Initial Enteral Feeding in Patients With Acute Severe Stroke

Conditions:   Severe Stroke;   Acute Stroke;   Dysphagia
Interventions:   Other: Initial enteral feeding;   Drug: erythromycin
Sponsors:   Xijing Hospital;   Tang-Du Hospital;   Xi'an Central Hospital;   Shaanxi Provincial People's Hospital;   Hanzhong Central Hospital;   Yan'an University Affiliated Hospital
Not yet recruiting - verified November 2016

Comparison of Compensatory Reserve Index to Changes in Stroke Volume and Intravascular Volume

Condition:   Hemorrhage
Intervention:   Device: Pulse Oximeter
Sponsors:   Flashback Technologies;   Duke University
Completed - verified December 2016

Effectiveness of Tele-rehabilitation Intervention to Improve Performance, Participation and Quality of Life for People Post Stroke

Condition:   Stroke, Acute
Intervention:   Behavioral: The Cognitive Orientation to daily Occupational Performance
Sponsor:   Hadassah Medical Organization
Not yet recruiting - verified November 2016

The Influence of Exercise on Neuroplasticity and Motor Learning After Stroke

Conditions:   Stroke;   Exercise;   Rest
Intervention:   Behavioral: Exercise
Sponsor:   University of British Columbia
Recruiting - verified November 2016

Controlling Hypertension After Severe Cerebrovascular Event

Conditions:   Severe Stroke;   Acute Stroke;   Hypertension
Intervention:   Other: Blood pressure management policies
Sponsors:   Xijing Hospital;   Tang-Du Hospital;   Xi'an Central Hospital;   Shaanxi Provincial People's Hospital;   Hanzhong Central Hospital;   Yan'an University Affiliated Hospital
Not yet recruiting - verified November 2016

A Home-based Intervention to Reduce Sedentary Behaviour and Improve Function After Stroke

Condition:   Stroke
Intervention:   Behavioral: Sedentary behaviour intervention
Sponsors:   University of Alberta;   Alberta Innovates Health Solutions;   Glenrose Rehabilitation Hospital Foundation
Recruiting - verified November 2016

Neopterin and Ischemic Stroke

Condition:   Stroke
Intervention:   Other: Neopterin
Sponsor:   Assiut University
Not yet recruiting - verified November 2016

Positive End-expiratory Pressure-induced Increase in Central Venous Pressure as a Predictor of Fluid Responsiveness in Robot-assisted Laparoscopic Surgery

Conditions:   Prostatic Neoplasm;   Urinary Bladder Neoplasm
Intervention:   Procedure: Fluid loading of volulyte 300 ml
Sponsor:   Seoul National University Hospital
Recruiting - verified November 2016

Acupuncture Treatment on Motor Dysfunction in Stroke Patients

Conditions:   Stroke;   Motor Disorders
Interventions:   Other: Acupuncture Treatment;   Other: Rehabilitation Treatment
Sponsors:   Shanghai University of Traditional Chinese Medicine;   Fudan University
Not yet recruiting - verified November 2016

Protective Effects of Normobaric Hyperoxia on Blood Brain Barrier in Patients With Acute Ischemic Stroke

Condition:   Stroke, Acute
Intervention:   Other: Normobaric oxygen therapy
Sponsor:   Capital Medical University
Not yet recruiting - verified November 2016

Passive Leg Raise Induced Stroke Volume Changes in Elderly Prior to Elective Surgery Measured by LiDCOplusTM

Conditions:   Stroke Volume;   Cardiovascular System;   Fluid Therapy
Intervention:   Other: Passive leg raise
Sponsor:   Karolinska Institutet
Completed - verified November 2016

Evaluation of Coronary Artery Plaque Volume Progression/Regression and Safety of Alirocumab in Japanese Patients Hospitalized for Acute Coronary Syndrome With Hypercholesterolemia

Conditions:   Hypercholesterolemia;   Acute Coronary Syndrome
Interventions:   Drug: alirocumab SAR236553;   Drug: atorvastatin;   Drug: rosuvastatin;   Drug: fenofibrate;   Drug: bezafibrate;   Drug: ezetimibe;   Drug: antiplatelets;   Drug: anticoagulants
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified November 2016

Diabetic Artery Obstruction: is it Possible to Reduce Ischemic Events With Cilostazol?

Conditions:   Ischemic Stroke;   Peripheral Artery Disease;   Diabetes Mellitus, Type 2
Interventions:   Drug: Clopidogrel;   Drug: Cilostazol
Sponsor:   University of Ioannina
Recruiting - verified December 2016

Left Atrial Appendage Occlusion and Biomarker Evaluation

Conditions:   Stroke;   Atrial Fibrillation;   Bleeding
Intervention:  
Sponsor:   Universitätsmedizin Mannheim
Recruiting - verified December 2016

Specific Respiratory Infections as Triggers of Acute Medical Events

Conditions:   Influenza, Human;   Respiratory Syncytial Virus Infections;   Parainfluenza;   Rhinovirus;   Adenovirus;   Human Metapneumovirus Pneumonia;   Cardiovascular Diseases
Intervention:  
Sponsors:   University College, London;   Public Health England
Active, not recruiting - verified November 2016

Postspinal Hypotension and Cardiac Performance in the Elderly

Condition:   ARTHROPLASTY, REPLACEMENT; ANESTHESIA
Intervention:   Other: Spinal anaesthesia
Sponsor:   Karolinska Institutet
Completed - verified November 2016

Trans Radial Versus Transfemoral Route for Coronary Angiography

Condition:   Coronary Artery Disease
Interventions:   Procedure: transradial;   Procedure: Transfemoral
Sponsor:   Sheri Kashmir Institute of Medical Sciences
Completed - verified December 2016

Neurological Outcome After Minimal Invasive Coronary Artery Bypass Graft

Conditions:   Postoperative Cognitive Dysfunction;   Cerebrovascular Accident;   Delirium
Interventions:   Procedure: Endo-CABG;   Procedure: PCI
Sponsors:   Jessa Hospital;   Hasselt University
Not yet recruiting - verified December 2016

Dabigatran Versus Conventional Treatment for Prevention of Silent Cerebral Infarct in Atrial Fibrillation Associated With Valvular Disease

Conditions:   Atrial Fibrillation;   Valve Heart Disease
Interventions:   Drug: Dabigatran;   Drug: Acetylsalicylic acid;   Drug: Warfarin
Sponsors:   Asan Medical Center;   Boehringer Ingelheim
Not yet recruiting - verified December 2016

Intelligent Activity-based Client-centred Training

Conditions:   Central Nervous System Diseases;   Aged
Intervention:   Device: i-ACT
Sponsors:   PXL University College;   Rehabilitation and MS centre Overpelt, Overpelt, Belgium;   Adelante, Centre of Expertise in Rehabilitation and Audiology
Not yet recruiting - verified December 2016

Bayraktutan Dunhill Medical Trust EPC Study

Condition:   Stroke
Intervention:  
Sponsors:   University of Nottingham;   The Dunhill Medical Trust
Not yet recruiting - verified November 2016

Effect of Remote Ischemic Preconditioning on Incidence of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft Surgery

Conditions:   Acute Kidney Injury;   Coronary Artery Bypass;   Ischemic Preconditioning
Interventions:   Procedure: Remote Ischemic Preconditioning (RIPC);   Procedure: sham-RIPC
Sponsor:   Shiraz University of Medical Sciences
Active, not recruiting - verified November 2016

ARENA - Project Atrial Fibrilation Rhine-Neckar Region

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Stiftung Institut fuer Herzinfarktforschung
Recruiting - verified November 2016

Clinical Outcomes and Efficacy of Left Ventricular Assist Device for Korean Patients With Cardiogenic Shock

Condition:   Shock, Cardiogenic
Intervention:  
Sponsor:   Jeong Hoon Yang
Recruiting - verified December 2016

Epicardial Fat Pads Ablation During Coronary Surgery

Conditions:   Atrial Fibrillation;   Ischemic Heart Disease
Interventions:   Procedure: Coronary artery bypass grafting;   Procedure: Epicardial ganglionated plexi ablation;   Procedure: implantable loop recorder
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Recruiting - verified December 2016

Apixaban Versus Warfarin in Patients With Left Ventricular Thrombus

Condition:   Left Ventricular Thrombosis
Interventions:   Drug: Apixaban 5 MG Oral Tablet [ELIQUIS];   Drug: Warfarin Sodium
Sponsors:   University of Science Malaysia;   INSTITUT JANTUNG NEGARA
Recruiting - verified November 2016

The New Pharmaceutical Composition Containing Botulinum Toxin to Treat Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Ischemic Heart Disease
Interventions:   Drug: Pharmaceutical composition containing botulinum toxin;   Drug: 0.9% normal saline;   Procedure: Coronary artery bypass grafting
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Recruiting - verified December 2016

Rivaroxaban or Aspirin for Biological Aortic Prosthesis

Conditions:   Aortic Stenosis;   Aortic Regurgitation;   Thrombosis
Interventions:   Drug: Rivaroxaban 10 MG;   Drug: Aspirin
Sponsors:   Christian Torp-Pedersen;   Aalborg Universitetshospital;   Aarhus University Hospital;   Odense University Hospital;   Rigshospitalet, Denmark
Not yet recruiting - verified November 2016

Fixed Low-dose Heparin Versus Standard Adjusted-dose Heparin Infusion in Adults Receiving Venovenous ECMO With a Heparin Bonded Circuit.

Conditions:   Acute Respiratory Failure;   Extracorporeal Membrane Oxygenation Complication;   Bleeding
Intervention:   Drug: HEP-IV
Sponsor:   University of Arizona
Recruiting - verified November 2016

Noninvasive Pulse Contour Analysis for Hemodynamic Assessment in Patients With Chronic Heart Failure

Condition:   Heart Failure
Interventions:   Device: Noninvasive pulse contour analysis;   Device: Pulmonary artery catheterization
Sponsor:   Heart and Diabetes Center North-Rhine Westfalia
Recruiting - verified November 2016

Radiation Dose Optimization in Diffuse Large B- Cell Lymphoma.

Condition:   NonHodgkin Lymphoma
Interventions:   Radiation: Standard Arm;   Radiation: Experimental Arm
Sponsor:   Tata Memorial Hospital
Recruiting - verified December 2016

Quantitative Coronary Angiography Versus Intravascular Ultrasound GUIDancE for Drug-Eluting Stent Implantation

Conditions:   Coronary Disease;   Coronary Stenoses
Interventions:   Device: quantitative coronary angiography guided coronary intervention with everolimus-eluting stent or zotarolimus-eluting stent;   Device: intravascular ultrasound guided coronary intervention with everolimus-eluting stent or zotarolimus-eluting stent
Sponsors:   CHEOL WHAN LEE, M.D., Ph.D;   CardioVascular Research Foundation, Korea
Not yet recruiting - verified November 2016

Study of Major Cardiovascular Events in Patients With Nonvalvular Atrial Fibrillation Treated With Rivaroxaban

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Not yet recruiting - verified November 2016

Erythrocyte Transfusion Based on the Measurement of Central Venous Oxygen Saturation in Postoperative Cardiac Surgery

Condition:   Cardiac Surgery
Intervention:   Other: SVO2 group / control group
Sponsor:   Centre Hospitalier Universitaire, Amiens
Not yet recruiting - verified November 2016

Safety and Efficacy of NA-1 in Subjects Undergoing Endovascular Thrombectomy for Stroke (ESCAPE-NA1)

Condition:   Stroke, Acute
Interventions:   Drug: NA-1, 2.6 mg/kg;   Drug: Placebo
Sponsors:   NoNO Inc.;   University of Calgary
Not yet recruiting - verified December 2016

Effect of Sedatives on Regional Cerebral Oxygen Saturation

Condition:   Cerebral Ischemia-Hypoxia
Interventions:   Drug: Midazolam;   Drug: Dexmedetomidine
Sponsor:   Gachon University Gil Medical Center
Recruiting - verified December 2016

Early Versus Late Sustained Low Efficiency Dialysis in Critically Ill Cirrhotics With Septic Shock and Acute Kidney Injury

Condition:   Cirrhotics With Septic Shock and Acute Kidney Injury
Interventions:   Biological: Early SLED;   Biological: Late SLED
Sponsor:   Institute of Liver and Biliary Sciences, India
Recruiting - verified October 2016

Epileptic Potentials During Cardiac Surgery and Association With Postoperative Neurological Outcome

Conditions:   Epilepsy;   Cardiac Disease;   Peroperative Complications;   Anesthesia; Adverse Effect;   Ischemia, Cerebral
Intervention:  
Sponsor:   Heiko Kaiser
Recruiting - verified November 2016

Deep Brain Stimulation Surgery for Focal Hand Dystonia

Conditions:   Dystonia;   Focal Dystonia;   Musician's Dystonia
Intervention:   Procedure: DBS surgery
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified November 2016

AMPLATZER™ Amulet™ LAA Occluder Trial

Condition:   Stroke
Interventions:   Device: Amulet Left Atrial Appendage Occluder;   Device: WATCHMAN Left Atrial Appendage Closure
Sponsor:   St. Jude Medical
Recruiting - verified November 2016

Assessment of a Physio-neuro Platform (SynPhNe) for Home-based Retraining of Hand Function in Stroke Survivors

Conditions:   Stroke;   Hemiparesis
Interventions:   Device: SynPhNe platform;   Other: Conventional therapy
Sponsor:   Spaulding Rehabilitation Hospital
Not yet recruiting - verified November 2016

Berlin PRehospital Or Usual Delivery of Acute Stroke Care

Condition:   Stroke
Interventions:   Procedure: STEMO;   Procedure: Regular care
Sponsors:   Charite University, Berlin, Germany;   Center for Stroke Research Berlin
Recruiting - verified November 2016

Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND)

Condition:   Anaemia
Interventions:   Drug: Daprodustat;   Drug: Darbepoetin alfa;   Drug: Placebo;   Drug: Iron Therapy
Sponsor:   GlaxoSmithKline
Recruiting - verified December 2016

Benefit-Risk Of Arterial THrombotic prEvention With Rivaroxaban for Atrial Fibrillation in France

Condition:   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Vitamin K antagonists;   Drug: dabigatran (Pradaxa)
Sponsor:   Bayer
Recruiting - verified November 2016

Antiplatelet Therapy in Acute Mild-Moderate Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: clopidogrel;   Drug: Aspirin
Sponsor:   General Hospital of Shenyang Military Region
Not yet recruiting - verified December 2016

Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31

Condition:   Hereditary Spastic Paraplegia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified November 2016

Study on the Effect of Influenza Vaccination After Heart Attack on Future Cardiovascular Prognosis

Conditions:   Myocardial Infarction;   Influenza, Human;   Influenza Vaccines;   Heart Failure;   Stroke
Interventions:   Biological: Influenza vaccine;   Biological: Placebo
Sponsors:   Ole Frobert, MD, PhD;   Swedish Heart Lung Foundation;   Sanofi Pasteur, a Sanofi Company;   Uppsala University;   Lytics
Recruiting - verified November 2016

Diabetes Complication Control in Community Clinics (D4C) Trial

Conditions:   Diabetes;   Hypertension;   Dyslipidemia;   Cardiovascular Disease
Intervention:   Other: Protocol-based integrated care
Sponsors:   Tulane University;   Xiamen University
Recruiting - verified November 2016

Preventing Epilepsy Using Vigabatrin In Infants With Tuberous Sclerosis Complex

Condition:   Tuberous Sclerosis Complex
Interventions:   Drug: Vigabatrin;   Drug: Placebo
Sponsors:   Martina Bebin;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 2016

Lifestyle Changes Through Exercise and Nutrition

Conditions:   Obesity;   Diabetes
Intervention:   Behavioral: Weight loss intervention
Sponsor:   Pennington Biomedical Research Center
Active, not recruiting - verified November 2016

Evaluation of the Implementation of the Hemispheric Dominance During Development

Condition:   Neuroimaging
Interventions:   Device: Electroencephalogram (EEG);   Device: Near Infra Red Spectroscopy (NIRS);   Device: magnetic resonance imaging (MRI)
Sponsor:   Centre Hospitalier Universitaire, Amiens
Active, not recruiting - verified December 2016

Effect of Tadalafil on Cerebral Large Arteries in Stroke

Conditions:   Stroke, Lacunar;   Cerebral Small Vessel Diseases
Interventions:   Drug: Tadalafil;   Drug: Placebo
Sponsor:   Christina Kruuse
Recruiting - verified November 2016

Does Sedation Depth (as Evaluated by the Bispectral Index) Influence Dynamic Indices of Preload Dependence?

Condition:   Thoracic Surgery
Intervention:   Device: transthoracic echocardiography
Sponsor:   Centre Hospitalier Universitaire, Amiens
Withdrawn - verified November 2016

Enhanced Detection of Underlying, Covert ATrial Fibrillation Using 7-day Holter Electrocardiogram in Patients With Embolic Stroke of Undetermined Source

Condition:   Stroke
Intervention:  
Sponsor:   National Cerebral and Cardiovascular Center
Recruiting - verified December 2016

Controlling And Lowering Blood Pressure With the MobiusHDTM Device

Condition:   Hypertension
Interventions:   Device: MobiusHD;   Other: Sham Implantation
Sponsor:   Vascular Dynamics, Inc.
Not yet recruiting - verified November 2016

Comparison of the Hemodynamic Safety of Two Common Alveolar Recruitment Manoeuvres With Regard to Cardiac Output in a Surgical Intensive Care Unit

Condition:   Positive-Pressure Respiration
Interventions:   Device: echocardiography;   Device: Arterial oximetry
Sponsor:   Centre Hospitalier Universitaire, Amiens
Terminated - verified December 2016

Comparing Unimanual and Bimanual Mirror Therapy for Upper Limb Recovery Post Stroke

Conditions:   Cerebral Vascular Accident (CVA);   Stroke
Interventions:   Behavioral: Traditional Home Based Exercise Program;   Behavioral: Unimanual Home Based Mirror Therapy Program;   Behavioral: Bimanual Home Based Mirror Therapy Program
Sponsor:   New York University School of Medicine
Recruiting - verified November 2016

Effect of Lipoprotein(a) Elimination by Lipoprotein Apheresis on Cardiovascular Outcomes

Condition:   Lipoprotein Types--Lp System Lp(A) Hyperlipoproteinemia
Intervention:  
Sponsors:   Technische Universität Dresden;   Kaneka Pharma Europe N.V., Triomflaan 173,1160 Brussels, Belgium
Recruiting - verified November 2016

A Study to Evaluate the Efficacy and Safety of TF0023 Spray on Subjects With Ischemic Strokes

Condition:   Ischemic Stroke
Intervention:   Drug: TF0023
Sponsor:   Techfields Inc
Recruiting - verified November 2016

Assessment of Arterial Dynamic Elastance as a Function Variable of Arterial Load

Condition:   Hypovolemia
Interventions:   Device: arterial line;   Device: Cheetah®
Sponsor:   Universitair Ziekenhuis Brussel
Recruiting - verified December 2016

Evaluation of the E/e' Ratio of the Mitral Annulus in Predicting Fluid Responsiveness.

Conditions:   Left Ventricular Function Diastolic Dysfunction;   Fluid Responsiveness
Intervention:   Other: Volume expansion
Sponsor:   Montreal Heart Institute
Recruiting - verified December 2016

Perinatal Stroke: Understanding Brain Reorganization

Conditions:   Stroke;   Hemiparesis
Interventions:   Device: Magnetic Resonance Imaging;   Device: Transcranial Magnetic Stimulation;   Behavioral: General Movement Assessment
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Cerebral Palsy Alliance Research Foundation;   American Academy of Cerebral Palsy and Developmental Medicine
Recruiting - verified November 2016

A Clinical Assessment Study in X-Linked Myotubular Myopathy (XLMTM) Subjects

Condition:   X-linked Myotubular Myopathy
Intervention:  
Sponsor:   Audentes Therapeutics
Recruiting - verified October 2016

Safety and Efficacy Study of a Protease Activated Receptor-4 Antagonist Being Tested to Reduce the Chances of Having Additional Strokes or "Mini Strokes"

Condition:   Thrombosis
Interventions:   Drug: BMS-986141;   Drug: Aspirin;   Other: Placebo
Sponsor:   Bristol-Myers Squibb
Recruiting - verified July 2016

Energy Consumption and Cardiorespiratory Load During Walking With and Without Robot-Assistance

Condition:   Stroke
Interventions:   Device: Lokomat;   Other: Treadmill;   Other: Overground
Sponsor:   Vrije Universiteit Brussel
Recruiting - verified December 2016

Myalgic Encephalomyelitis Chronic Fatigue at the National Institutes of Health

Condition:   Chronic Fatigue Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 2016

INVEST: Minimally Invasive Endoscopic Surgery vs. Medical Management in Supratentorial Intraparenchymal Hemorrhage

Condition:   Intracranial Hemorrhage
Interventions:   Device: Apollo MIES;   Other: Medical Management
Sponsor:   J. Mocco
Not yet recruiting - verified December 2016

Tumor Related Epilepsy

Conditions:   Epilepsy;   Cancer;   Brain Neoplasm
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified November 2016

Randomized Comparison of DCB for the Treatment of Superficial Femoral and Popliteal Peripheral Artery Disease

Conditions:   Angioplasty, Balloon;   Catheterization, Peripheral;   Popliteal Artery;   Femoral Artery
Interventions:   Device: IN.PACT drug coated balloon;   Device: Lutonix drug coated balloon
Sponsor:   Seung-Whan Lee, M.D., Ph.D.
Recruiting - verified November 2016

A Study of the ReCor Medical Paradise System in Clinical Hypertension

Conditions:   Hypertension;   Vascular Diseases
Interventions:   Device: The Paradise® Renal Denervation Ultrasound System;   Device: Sham Procedure
Sponsor:   ReCor Medical, Inc.
Recruiting - verified July 2016

HBOT Global Functioning After Stroke

Condition:   Stroke
Interventions:   Other: Hyperbaric Oxygen Therapy (HBOT) and Exercise Program;   Other: Exercise Program;   Device: Hyperbaric Multiplace Chamber
Sponsor:   University Health Network, Toronto
Recruiting - verified December 2016

Monitoring Changes in Blood Pressure

Condition:   Blood Pressure
Intervention:   Device: EarlySense (Passive monitoring)
Sponsor:   EarlySense Ltd.
Completed - verified September 2016

Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor

Conditions:   Traumatic Brain Injury;   Ischemic Stroke;   Intracerebral Hemorrhage;   Subarachnoid Hemorrhage;   Acute Anoxic Encephalopathy
Intervention:   Drug: Indocyanine Green
Sponsor:   University of Pennsylvania
Recruiting - verified December 2016

Study of Urate Elevation in Parkinson's Disease, Phase 3

Condition:   Parkinson's Disease
Interventions:   Drug: Inosine;   Drug: Placebo
Sponsors:   Michael Alan Schwarzschild;   The Parkinson Study Group;   Michael J. Fox Foundation for Parkinson's Research;   University of Rochester;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 2016

A Study to Compare Tivozanib Hydrochloride to Sorafenib in Subjects With Refractory Advanced RCC

Condition:   Carcinoma, Renal Cell
Interventions:   Drug: tivozanib hydrochloride;   Drug: Sorafenib
Sponsor:   AVEO Pharmaceuticals, Inc.
Recruiting - verified December 2016

Improving Quality by Maintaining Accurate Problems in the EHR

Conditions:   Asthma;   Atrial Fibrillation;   Chronic Obstructive Pulmonary Disease;   Coronary Artery Disease;   Congestive Heart Failure;   Hyperlipidemia;   Hypertension;   Myocardial Infarction;   Sickle Cell Disease;   Sleep Apnea;   Smoking;   Stroke;   Tuberculosis
Intervention:   Other: Problem List Suggestion
Sponsors:   Brigham and Women's Hospital;   Geisinger Clinic;   Oregon Health and Science University;   Vanderbilt University
Active, not recruiting - verified December 2016

Clinical Study of the Aorta-femoral Bypass and Hybrid Intervention and the Iliac Arteries With Stenting and Plasty of the Common Femoral Artery Effectiveness in Patients With the Iliac Segment and Femoral Artery Occlusive Disease (TASC C, D)

Condition:   Atherosclerosis of the Peripheral Arteries
Interventions:   Procedure: Hybrid Intervention;   Procedure: Aorta femoral Bypass
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Active, not recruiting - verified November 2016

Psychoeducation for Transient Ischaemic Attack and Minor Stroke

Conditions:   Transient Ischaemic Attack;   Stroke
Intervention:   Behavioral: Psychoeducation
Sponsors:   University of Nottingham;   The Stroke Association, United Kingdom;   Nottingham University Hospitals NHS Trust
Recruiting - verified October 2016

Special Drug Use Investigation of Xarelto for Venous Thromboembolism (VTE)

Condition:   Venous Thromboembolism
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified November 2016

Global Study Comparing a rivAroxaban-based Antithrombotic Strategy to an antipLatelet-based Strategy After Transcatheter aortIc vaLve rEplacement to Optimize Clinical Outcomes

Condition:   Transcatheter Aortic Valve Replacement
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Acetylsalicylic acid;   Drug: Clopidogrel
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting - verified November 2016

Prospective Record Of the Use of Dabigatran in Patients With Acute Stroke or TIA

Conditions:   Brain Ischemia With Non-valvular Atrial Fibrillation;   Transient Ischemic Attack With Non-valvular Atrial Fibrillation
Intervention:  
Sponsor:   University Hospital, Essen
Recruiting - verified November 2016

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Recruiting - verified December 2016

Reduction of Aspiration Through Cohesive Thin Liquids (CTL) in Patients With Mild Oropharyngeal Dysphagia

Conditions:   Dysphagia;   Stroke
Interventions:   Other: Cereal extract concentration 1;   Other: Cereal extract concentration 2;   Other: Cereal extract concentration 3;   Other: Thicken up clear concentration 1;   Other: Thicken up clear concentration 2;   Other: Thicken up clear concentration 3
Sponsor:   Nestlé
Recruiting - verified November 2016

Dynamic Preload Dependence Indices in Laparoscopic Surgery

Condition:   Laparoscopic Surgery
Intervention:   Procedure: Study of preload dependence indices after volume expansion in laparoscopy with Saldinger technique.
Sponsor:   Hospices Civils de Lyon
Recruiting - verified July 2015

Rivaroxaban Utilization for Treatment and Prevention of Thromboembolism in Cancer Patients: Experience at a Comprehensive Cancer Center

Conditions:   Cancer;   Deep-vein Thrombosis of the Lower and Upper Extremities;   Pulmonary Embolism;   Non-valvular Atrial Fibrillation
Intervention:   Other: Retrospective Chart Review
Sponsors:   M.D. Anderson Cancer Center;   Janssen Scientific Affairs, LLC
Recruiting - verified December 2016

Home-based Non-invasive Brain Stimulation and Hand Tracking Rehabilitation for People With Chronic Stroke

Condition:   Stroke
Intervention:   Device: Transcranial direct current stimulation (tDCS)
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Not yet recruiting - verified December 2016

Addressing Real-world Anticoagulant Management Issues in Stroke

Conditions:   Stroke;   Cerebrovascular Stroke;   Intracerebral Hemorrhage
Intervention:  
Sponsors:   Duke University;   Janssen, LP;   Genentech, Inc.;   Daiichi Sankyo Inc.;   American Heart Association
Enrolling by invitation - verified November 2016

Assessment of the GORE® EXCLUDER® Conformable AAA Endoprosthesis in the Treatment of Abdominal Aortic Aneurysms

Condition:   Aortic Aneurysm, Abdominal
Intervention:   Device: GORE® EXCLUDER® Conformable AAA Endoprosthesis
Sponsor:   W.L.Gore & Associates
Not yet recruiting - verified November 2016

Prompt Diagnosis and Treatment of Subclinical Seizures After Cardiac Arrest

Conditions:   Heart Arrest;   Seizures
Intervention:   Procedure: DSA EEG
Sponsors:   Children's Hospital of Philadelphia;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 2016

Study to Document the Effectiveness of Dysport in Patients Suffering From Upper Limb Spasticity (ULS) After Stroke

Condition:   Post Stroke Arm Spasticity
Intervention:  
Sponsor:   Ipsen
Completed - verified November 2016

Neural Control of Bilateral Movements After SCI

Condition:   Spinal Cord Injury
Interventions:   Device: Magstim 200;   Device: Digitimer electrical stimulator
Sponsors:   University of Miami;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 2016

Corticospinal Function After Spinal Cord Injury

Condition:   Spinal Cord Injury
Interventions:   Other: Electrophysiology Assessment of Time Domain;   Other: Electrophysiology Assessment of Location;   Other: Training with some stimulation
Sponsors:   University of Miami;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 2016

Study of Compound Edaravone Injection for Treatment of Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke
Interventions:   Drug: Compound Edaravone Injection;   Drug: Edaravone Injection
Sponsor:   Jiangsu Simcere Pharmaceutical Co., Ltd.
Active, not recruiting - verified April 2016

Checking a Security Protocol of Modified FUT and Efficacy Reducing the Constriction the Movement Time in 12 Hours

Condition:   Stroke
Interventions:   Device: Tubular mesh.;   Other: Classical kinesiotherapy.
Sponsor:   University of Sao Paulo
Recruiting - verified August 2016

Intraoperative Fluid Therapy for Deceased Donor Renal Transplantation

Condition:   Kidney Failure
Intervention:   Device: Esophageal Doppler Monitor
Sponsor:   University Health Network, Toronto
Completed - verified December 2016

Cord Blood Infusion for Ischemic Stroke

Condition:   Stroke
Intervention:   Biological: allogeneic umbilical cord blood
Sponsor:   Joanne Kurtzberg, MD
Active, not recruiting - verified November 2016

Botulinum Toxin A Associated Costs in the Treatment of Upper Limb Spasticity Post Stroke

Condition:   Upper Limb Spasticity Post-Stroke
Intervention:  
Sponsor:   Ipsen
Active, not recruiting - verified November 2016

Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy

Conditions:   Giant Axonal Neuropathy;   Gene Transfer
Intervention:   Drug: Intrathecal Delivery of scAAV9/JeT-GAN
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified November 2016

Evaluation of Valiant Mona LSA

Condition:   Aortic Aneurysm, Thoracic, Chronic Type B Dissection
Intervention:   Device: Valiant Mona LSA Thoracic Stent Graft System
Sponsor:   Medtronic Endovascular
Suspended - verified November 2016

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

Conditions:   FTLD;   Progressive Supranuclear Palsy (PSP);   Frontotemporal Dementia (FTD);   Corticobasal Degeneration (CBD);   PPA Syndrome;   Behavioral Variant Frontotemporal Dementia (bvFTD);   Semantic Variant Primary Progressive Aphasia (svPPA);   Nonfluent Variant Primary Progressive Aphasia (nfvPPA);   FTD With Amyotrophic Lateral Sclerosis (FTD/ALS);   Amyotrophic Lateral Sclerosis (ALS);   Oligosymptomatic PSP (oPSP);   Corticobasal Syndrome (CBS)
Intervention:  
Sponsors:   University of California, San Francisco;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   The Bluefield Project;   Tau Consortium
Recruiting - verified December 2016

PCORI-1310-06998 Trial of a Decision Support Intervention for Patients and Caregivers Offered Destination Therapy Heart Assist Device

Conditions:   Heart Failure;   Heart-assist Devices
Intervention:   Behavioral: DT LVAD Decision Support Intervention
Sponsors:   University of Colorado, Denver;   Patient-Centered Outcomes Research Institute
Recruiting - verified December 2016

Revascularization With BVS or CABG in Patients With Advanced CAD

Condition:   Multivessel Coronary Artery Disease
Interventions:   Procedure: PCI -BVS;   Procedure: CABG
Sponsor:   Poznan University of Medical Sciences
Terminated - verified November 2016

Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)

Condition:   Stroke
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin (Acetylsalicylic acid, BAY1019036);   Other: Rivaroxaban-Placebo;   Other: Aspirin-Placebo
Sponsors:   Bayer;   Janssen, LP;   Hamilton Health Sciences Cooperation, Population Health Research Institute
Recruiting - verified November 2016

Berlin Atrial Fibrillation Registry

Conditions:   Acute Ischemic Stroke;   Atrial Fibrillation
Intervention:  
Sponsors:   Charite University, Berlin, Germany;   Center for Stroke Research Berlin;   Bayer Healthcare Pharmaceuticals, Inc./Bayer Schering Pharma
Active, not recruiting - verified November 2016

Tranexamic Acid Mechanisms and Pharmacokinetics in Traumatic Injury

Conditions:   Hemorrhage;   Shock;   Wounds and Injuries
Interventions:   Drug: Tranexamic Acid;   Other: Placebo
Sponsors:   Washington University School of Medicine;   United States Department of Defense
Recruiting - verified November 2016

Optimizing Health Outcomes in Patients With Symptomatic Aortic Valve Disease

Condition:   Aortic Valve Disease
Intervention:  
Sponsors:   Duke University;   Patient-Centered Outcomes Research Institute;   American College of Cardiology;   The Society of Thoracic Surgeons
Enrolling by invitation - verified November 2016

Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

Conditions:   Stroke;   Secondary Prevention
Interventions:   Drug: optional ASA as comedication;   Drug: placebo to ASA;   Drug: placebo to optional ASA as comedication;   Drug: placebo to dabigatran etexilate;   Drug: ASA 100 mg;   Drug: dabigatran etexilate
Sponsor:   Boehringer Ingelheim
Recruiting - verified December 2016

Brain Stimulation and Hand Training in Children With Hemiparesis

Condition:   Pediatric Hemiparesis
Interventions:   Device: Transcranial Direct Current Stimulation (tDCS);   Device: Placebo Comparator
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Cerebral Palsy International Research Foundation;   Foundation for Physical Therapy, Inc.;   NIH K01 Career Development Award
Active, not recruiting - verified November 2016

Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)

Conditions:   Atrial Fibrillation;   Percutaneous Coronary Intervention
Interventions:   Drug: Dabigatran Etexilate 110mg;   Drug: Warfarin 3mg;   Drug: Aspirin;   Drug: Dabigatran Etexilate 150mg;   Drug: Clopidogrel or Ticagrelor;   Drug: Clopidogrel or Ticagrelor;   Drug: Warfarin 5mg;   Drug: Clopidogrel or Ticagrelor;   Drug: Warfarin 1mg
Sponsor:   Boehringer Ingelheim
Recruiting - verified October 2016

A Blinded Study to Evaluate Effect on Atrial Fibrillation Burden in Patients With Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Interventions:   Drug: BMS-919373;   Drug: Placebo (Matching with BMS-919373)
Sponsor:   Bristol-Myers Squibb
Completed - verified June 2016

Effect of Vorinostat on Nervous System Hemangioblastomas in Von Hippel-Lindau Disease (Missense Mutation Only)

Condition:   Von Hippel-Lindau Disease
Intervention:   Drug: Vorinostat
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified October 2016

Neurocognitive Robot-assisted Rehabilitation of Hand Function After Stroke

Conditions:   Stroke;   Upper Extremity Paresis
Interventions:   Device: robot-assisted neurocognitive therapy of hand function;   Other: Conventional neurocognitive rehabilitation
Sponsor:   Roger Gassert
Active, not recruiting - verified November 2016

A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients

Conditions:   Heart Failure;   Respiratory Insufficiency;   Stroke Acute;   Infectious Diseases;   Rheumatic Diseases
Interventions:   Drug: Rivaroxaban, 10 mg;   Drug: Rivaroxaban, 7.5 mg;   Drug: Placebo
Sponsor:   Janssen Research & Development, LLC
Recruiting - verified November 2016

Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia

Condition:   Eligible Men or Women Considered High Risk for Atherosclerotic Cardiovascular Disease (CVD)
Interventions:   Drug: Epanova® (omega-3 carboxylic acids);   Drug: corn oil control
Sponsors:   AstraZeneca;   Cleveland Clinic Coordinating Center for Clinical Research (C5R);   Quintiles, Inc.
Recruiting - verified November 2016

fMRI Neurofeedback for Motor Rehabilitation

Conditions:   Stroke;   fMRI
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 2016

Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic VTE(Venous Thromboembolism)

Conditions:   Pulmonary Embolism;   Thromboembolism;   Thrombosis;   Venous Thrombosis;   Venous Thromboembolism
Interventions:   Drug: BAY 59-7939;   Drug: BAY 59-7939;   Drug: ASA
Sponsor:   Bayer
Completed - verified November 2016

RELIEF Study: Lower Limb Pain Relief After Injection Cycles in Adults Suffering From Lower Limb Spasticity Following Stroke

Condition:   Lower Limb Spasticity
Intervention:   Drug: Botulinum Toxin Type A (BoNT-A) Injection
Sponsor:   Ipsen
Active, not recruiting - verified November 2016

Comparison of Physiological Variables During Blood Donation

Condition:   Hemorrhage
Intervention:  
Sponsors:   University of Colorado, Denver;   Flashback Technologies
Completed - verified December 2016

Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency

Conditions:   Metabolic Disease;   Seizures
Interventions:   Drug: SGS-742;   Drug: Placebo
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 2016

Generation of a Cellular Model of CADASIL From Skin Fibroblasts

Condition:   CADASIL
Intervention:   Other: Skin biopsy
Sponsor:   Institut National de la Santé Et de la Recherche Médicale, France
Enrolling by invitation - verified December 2016

Synergistic Enteral Regimen for Treatment of the Gangliosidoses

Conditions:   GM1 Gangliosidoses;   GM2 Gangliosidoses;   Tay-Sachs Disease;   Sandhoff Disease
Interventions:   Drug: miglustat;   Other: Ketogenic Diet
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   Lysosomal Disease Network
Recruiting - verified December 2016

A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Ticagrelor 60 mg;   Drug: Ticagrelor placebo
Sponsor:   AstraZeneca
Active, not recruiting - verified November 2016

Cardiovascular Outcomes Following Ertugliflozin Treatment in Type 2 Diabetes Mellitus Participants With Vascular Disease, The VERTIS CV Study (MK-8835-004)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Ertugliflozin;   Drug: Placebo
Sponsors:   Merck Sharp & Dohme Corp.;   Pfizer
Recruiting - verified November 2016

Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing

Condition:   Prophylaxis of Acute Mountain Sickness
Intervention:   Drug: Acetazolamide
Sponsor:   University of Utah
Completed - verified November 2016

The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Terminated - verified December 2016

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Terminated - verified December 2016

Detection and Neurological Impact of CerebroVascular Events In Noncardiac Surgery PatIents: A COhort EvaluatioN

Condition:   Covert Postoperative Stroke
Intervention:  
Sponsors:   Hamilton Health Sciences Corporation;   McMaster University;   Health and Medical Research Fund, Food and Health Bureau, Hong Kong;   Prince of Wales Hospital, Shatin, Hong Kong;   Chinese University of Hong Kong
Recruiting - verified December 2016

Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation

Conditions:   Amyotrophic Lateral Sclerosis;   Frontotemporal Lobar Degeneration
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Aging (NIA)
Recruiting - verified November 2016

A Toolbox Approach to Obesity Treatment in Primary Care

Condition:   Obesity
Interventions:   Behavioral: Commercial weight loss program;   Behavioral: Colorado Weigh;   Dietary Supplement: Meal replacements;   Drug: Obesity pharmacotherapy;   Behavioral: Recreation center passes
Sponsor:   Denver Health and Hospital Authority
Active, not recruiting - verified November 2016

Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery

Conditions:   Aphasia;   Dysgraphia;   Anomia;   Agrammatism;   Stroke
Interventions:   Behavioral: Treatment Focusing on Naming Objects;   Behavioral: Treatment Focusing on Improving Spelling Abilities;   Behavioral: Treatment Focusing on Improving Sentence Processing;   Behavioral: No Treatment
Sponsors:   Northwestern University;   National Institute on Deafness and Other Communication Disorders (NIDCD);   National Institutes of Health (NIH)
Recruiting - verified December 2016

Community Level Interventions for Pre-eclampsia

Conditions:   Pre-eclampsia;   Hypertension, Pregnancy Induced
Interventions:   Behavioral: Community Engagement;   Device: PIERS on the Move mHealth decision aid;   Drug: Magnesium Sulfate;   Drug: Methyldopa
Sponsors:   University of British Columbia;   Bill and Melinda Gates Foundation;   Olabisi Onabanjo University;   Centro de Investigacao em Saude de Manhica;   Aga Khan University;   Jawaharlal Nehru Medical College
Recruiting - verified November 2016

A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure

Conditions:   Heart Failure;   Coronary Artery Disease
Interventions:   Drug: Rivaroxaban;   Drug: Placebo;   Other: Standard of care for heart failure and coronary artery disease
Sponsors:   Janssen Research & Development, LLC;   Bayer
Recruiting - verified November 2016

ALdosterone Antagonist Chronic HEModialysis Interventional Survival Trial

Condition:   End Stage Renal Failure on Dialysis
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   University Hospital, Brest;   Central Hospital, Nancy, France;   Institut National de la Santé Et de la Recherche Médicale, France
Recruiting - verified November 2016

Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage

Conditions:   Cerebrovascular Disorders;   Brain Lesions;   Degenerative Diseases;   Developmental Pathology
Interventions:   Behavioral: Neuropsychological testing;   Other: MRI
Sponsor:   University Hospital, Rouen
Recruiting - verified December 2016

Skeletal Muscle Biomarkers in People With Fragile Sarcolemmal Muscular Dystrophy

Condition:   Genetic Disorder
Intervention:  
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institutes of Health Clinical Center (CC);   University of Massachusetts, Worcester
Recruiting - verified December 2016

Heart Outcomes Prevention and Evaluation 4

Conditions:   Hypertension;   Cardiovascular Disease
Interventions:   Other: Intervention;   Other: Usual Care
Sponsors:   Hamilton Health Sciences Corporation;   Population Health Research Institute;   Canadian Institutes of Health Research (CIHR);   Grand Challenges Canada;   Global Alliance for Chronic Diseases
Recruiting - verified November 2016

Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis

Conditions:   Cryptococcal Meningitis;   Fungal Meningitis
Intervention:   Drug: Sertraline
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Infectious Disease Institute, Kampala, Uganda;   National Institute of Neurological Disorders and Stroke (NINDS);   Mbarara University of Science and Technology;   Ifakara Health Institute
Recruiting - verified December 2016

5 Year Observation of Patients With PORTICO Valves

Condition:   Aortic Valve Stenosis
Interventions:   Device: St Jude Medical Portico replacement aortic valve;   Procedure: Transcatheter Aortic Valve Implant
Sponsor:   St. Jude Medical
Recruiting - verified November 2016

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab;   Drug: Placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified November 2016

Cardiovascular Inflammation Reduction Trial

Condition:   Cardiovascular Disease
Interventions:   Drug: Methotrexate;   Drug: Placebo
Sponsors:   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified November 2016

Deep Brain Stimulation Surgery for Movement Disorders

Conditions:   Parkinson's Disease;   Essential Tremor;   Dystonia
Intervention:   Procedure: Deep Brain Stimulation
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 2016

Study of Psychological and Motor Effects of Testosterone in Adolescents With XXY/Klinefelter Syndrome

Conditions:   Klinefelter Syndrome;   XXY Syndrome
Interventions:   Drug: Testosterone gel 1%;   Drug: Placebo gel
Sponsors:   University of Colorado, Denver;   Colorado Clinical & Translational Sciences Institute;   Children's Hospital Colorado;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 2016

Spinal Cord Injury Leg Rehabilitation

Conditions:   Spinal Cord Injury;   Paraplegia;   Quadriplegia;   Tetraplegia
Intervention:   Device: AMES Treatment
Sponsors:   Oregon Health and Science University;   Shepherd Center, Atlanta GA;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified November 2016

International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Coronary Artery Disease;   Heart Diseases;   Myocardial Ischemia
Interventions:   Procedure: cardiac catheterization;   Procedure: coronary artery bypass graft surgery;   Procedure: percutaneous coronary intervention;   Behavioral: Lifestyle;   Drug: Medication
Sponsors:   New York University School of Medicine;   New York University;   Stanford University;   National Heart, Lung, and Blood Institute (NHLBI);   Albany Stratton VA Medical Center;   Cedars-Sinai Medical Center;   Columbia University;   Duke University;   East Carolina University;   Emory University;   Harvard University;   Massachusetts General Hospital;   Montreal Heart Institute;   University of British Columbia;   University of Missouri, Kansas City;   Vanderbilt University
Recruiting - verified December 2016

Randomized, Open Label Trial of 6 Months Versus 12 Months DAPT After Drug-Eluting Stent in STEMI

Conditions:   Myocardial Infarction;   Cardiovascular Disease
Interventions:   Other: 6 months DAPT;   Other: 12 months DAPT
Sponsors:   Maasstad Hospital;   Medtronic
Active, not recruiting - verified December 2016

Clinical Trial on the Use of 25-OH -D Vitamin in Haemodialysis Patients

Condition:   Chronic Renal Failure
Intervention:   Drug: 25-OH-D vitamin
Sponsors:   Italian Society of Nephrology;   Società Italiana di Nefrologia
Terminated - verified November 2016

Hyper-CVAD and Ponatinib in Ph-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia (ALL)

Condition:   Leukemia
Interventions:   Drug: Cyclophosphamide;   Drug: Mesna;   Drug: Doxorubicin;   Drug: Vincristine;   Drug: Dexamethasone;   Drug: Ponatinib;   Drug: G-CSF (Filgrastim);   Drug: Rituximab;   Drug: Methotrexate;   Drug: Cytarabine;   Drug: Solu-medrol ( Methyl Prednisolone);   Drug: Citrovorum (Leucovorin);   Drug: Prednisone;   Drug: Pegfilgrastim (Neulasta)
Sponsors:   M.D. Anderson Cancer Center;   Ariad Pharmaceuticals
Recruiting - verified November 2016

Mifepristone for Metabolic Syndrome

Conditions:   Endocrine Disease;   Diabetes
Intervention:   Drug: Mifepristone
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified February 2016

Cognitive Rehabilitation and Galantamine for Post Stroke Cognitive Impairment

Conditions:   Stroke;   Cognitive Impairment
Interventions:   Drug: Galantamine;   Drug: placebo
Sponsor:   Institut National de la Santé Et de la Recherche Médicale, France
Recruiting - verified April 2015

Allogeneic Genoidentical Stem Cell Transplantation in Children With Sickle-cell Anemia and Cerebral Vasculopathy

Conditions:   Sickle Cell Anemia;   Cerebrovascular Accident
Interventions:   Procedure: Stem cell transplantation;   Procedure: Transfusion program
Sponsor:   Assistance Publique - Hôpitaux de Paris
Completed - verified November 2016

Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression

Conditions:   Atherosclerosis;   Hypercholesterolemia
Interventions:   Drug: Statin Drugs;   Other: HMG-CoA Reductase Inhibitors
Sponsor:   National Institutes of Health Clinical Center (CC)
Active, not recruiting - verified March 2016

Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis

Condition:   Sinus Thrombosis, Intracranial
Interventions:   Drug: Endovascular thrombolysis;   Drug: Heparin
Sponsors:   Jan Stam, MD, PhD;   Dutch Heart Foundation
Recruiting - verified November 2016

Neural Dynamics and Connectivity in Response Inhibition and Traumatic Brain Injury

Conditions:   Traumatic Brain Injury;   Stroke;   Headache;   PTSD
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   United States Department of Defense;   Center for Neuroscience and Regenerative Medicine (CNRM);   National Institutes of Health Clinical Center (CC)
Recruiting - verified November 2016

Remote Ischemic Preconditioning in Subarachnoid Hemorrhage

Conditions:   Subarachnoid Hemorrhage, Aneurysmal;   Subarachnoid Hemorrhage;   Cerebral Vasospasm;   Intracranial Aneurysm
Intervention:   Procedure: Remote ischemic preconditioning
Sponsor:   University of California, Los Angeles
Completed - verified November 2016

Investigating Mechanism of Action of DAC HYP in the Treatment of High-Inflammatory Multiple Sclerosis (MS)

Conditions:   Multiple Sclerosis;   Multiple Sclerosis, Relapsing-Remitting
Intervention:   Biological: DAC-HYP
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified October 2016

The Neurotrophic Effects of Lithium Carbonate Following Stroke: A Feasibility Study

Condition:   Stroke
Intervention:   Drug: Lithium Carbonate
Sponsor:   Sunnybrook Health Sciences Centre
Recruiting - verified December 2016

CANVAS - CANagliflozin cardioVascular Assessment Study

Conditions:   Diabetes Mellitus, Type 2;   Cardiovascular Diseases;   Risk Factors
Interventions:   Drug: Canagliflozin (JNJ-28431754);   Drug: Placebo
Sponsors:   Janssen Research & Development, LLC;   The George Institute for Global Health, Australia
Active, not recruiting - verified November 2016

Physiological Investigations of Movement Disorders

Conditions:   Parkinson's Disease;   Tourette's Syndrome;   Tic Disorders;   Dystonia;   Movement Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified November 2016

Safety Escalating Repeat IV, in Stroke Patients

Condition:   Ischaemic Attack, Transient
Interventions:   Drug: GSK249320;   Drug: PLACEBO
Sponsor:   GlaxoSmithKline
Completed - verified November 2016

Biomarkers of Risk of Parkinson Disease

Conditions:   Parkinson Disease;   Autonomic Nervous System Diseases;   Pure Autonomic Failure
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified November 2016

Phase 2 Study of the Safety, Tolerability and Pilot Efficacy of Oral Factor Xa Inhibitor Betrixaban Compared to Warfarin

Condition:   Atrial Fibrillation
Interventions:   Drug: betrixaban;   Drug: Warfarin
Sponsor:   Portola Pharmaceuticals
Completed - verified November 2016

A Natural History Study of the Gangliosidoses

Conditions:   Tay-Sachs Disease;   Sandhoff Disease;   Late Onset Tay-Sachs Disease;   GM1 Gangliosidosis;   GM2 Gangliosidosis
Intervention:  
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   Lysosomal Disease Network
Recruiting - verified December 2016

Self Care TALK Study - Promoting Stroke Caregiver Health

Condition:   Caregiving
Intervention:   Behavioral: Self Care Talk
Sponsors:   University of Kansas Medical Center;   American Heart Association
Completed - verified November 2016

Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome

Condition:   Antiphospholipid Syndrome
Intervention:  
Sponsor:   Duke University
Recruiting - verified July 2016

Neuropathology of Spasmodic Dysphonia

Condition:   Voice Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified November 2016

Evaluation and Treatment of Neurosurgical Disorders

Condition:   Neurologic Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified November 2016

Study of Specimens Obtained During Epilepsy Surgery

Condition:   Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified November 2016