Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Registry of Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler in Chinese Population

Conditions:   Right-to-left Shunt;   Migraine;   Cerebral Infarction
Intervention:  
Sponsor:   Yingqi Xing
Not yet recruiting - verified April 2015

Transcranial Direct Current Stimulation on the Risk of Falls and Lower Limb Function for Acute Stroke

Condition:   Stroke
Interventions:   Device: Anodal transcranial direct current stimulation;   Device: Cathodal transcranial direct current stimulation;   Device: Bilateral transcranial direct current stimulation;   Device: Sham transcranial direct current stimulation
Sponsor:   Federal University of Paraíba
Completed - verified April 2015

Women's Health Initiative Strong and Healthy Study

Conditions:   Myocardial Infarction;   Stroke;   Cardiovascular Mortality;   Hip Fractures;   Falls;   Mortality;   Venous Thromboembolic Event;   Peripheral Artery Disease
Intervention:   Behavioral: Physical Activity
Sponsors:   Fred Hutchinson Cancer Research Center;   University of California, San Diego;   Stanford University;   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation - verified April 2015

Feasibility of Using Prism Adaptation to Treat Spatial Neglect and Motor Function in Stroke

Condition:   Stroke
Intervention:   Behavioral: Prism Adaptation
Sponsor:   Kessler Foundation
Recruiting - verified April 2015

An Extension Study to Evaluate the Long-Term Safety, Tolerability and Efficacy of Dalfampridine Extended-Release Tablets for the Treatment of Chronic Post-Ischemic Stroke Walking Deficits in Subjects Who Participated in the DALF-PS-1016 Study

Condition:   Post-ischemic Stroke
Interventions:   Drug: dalfampridine-ER 7.5 mg;   Drug: dalfampridine-ER 10 mg
Sponsor:   Acorda Therapeutics
Recruiting - verified April 2015

A Study of tDCS for Swallowing Difficulties in Stroke Patients

Condition:   Stroke
Interventions:   Device: Eldith DC-STIMULATOR;   Device: Sham Eldith DC-STIMULATOR
Sponsor:   Pusan National University School of Medicine
Recruiting - verified April 2015

Left Atrial Appendage Closure vs. Novel Anticoagulation Agents in Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Drug: apixaban;   Device: Left atrial appendage closure - Watchman device preferentially
Sponsors:   Charles University, Czech Republic;   Ministry of Health, Czech Republic
Active, not recruiting - verified April 2015

Oral Guanabenz for Multiple Sclerosis

Conditions:   Multiple Sclerosis, Relapsing-Remitting;   Multiple Sclerosis
Intervention:   Drug: Guanabenz
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Morbidity and Mortality in Patients With Hypertrophic Cardiomyopathy: a CALIBER Study

Condition:   Hypertrophic Cardiomyopathy
Intervention:   Other: No intervention
Sponsors:   University College, London;   Inherited Cardiac Diseases Unit, The Heart Hospital, London
Active, not recruiting - verified April 2015

Stem Cell Therapy For Acute Ischemic Stroke Patients

Conditions:   Middle Cerebral Artery Infarction;   Anterior Cerebral Artery Infarction
Intervention:   Other: BMSCs
Sponsors:   All India Institute of Medical Sciences, New Delhi;   Ministry of Science and Technology, India;   Army Hospital Research and Referral, New Delhi;   Armed Forces Medical College, Pune;   Postgraduate Institute of Medical Education and Research;   Sanjay Gandhi Postgraduate Institute of Medical Sciences
Completed - verified April 2015

Better Adherence With New Oral Anticoagulant in Atrial Fibrillation : Effectiveness of a Personalized Education Program

Condition:   Non-valvular Atrial Fibrillation
Interventions:   Drug: Xarelto;   Other: Experimental: Personalized information intervention
Sponsor:   University Hospital, Montpellier
Recruiting - verified April 2015

Feasibility Study of Deep Brain Recordings for Learning and Memory

Condition:   Movement Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified March 2015

Brain Connectivity Supporting Language Recovery in Aphasia

Conditions:   Aphasia;   Stroke;   Speech Disorders;   Communications Disorders
Intervention:  
Sponsors:   Medical University of South Carolina;   National Institute on Deafness and Other Communication Disorders (NIDCD);   University of South Carolina
Recruiting - verified April 2015

Study Apixaban to Vitamin K Antagonist for the Prevention of Stroke or Systemic Embolism and Bleeding in Patients With Non-valvular Atrial Fibrillation and Acute Coronary Syndrome/Percutaneous Coronary Intervention

Condition:   Acute Coronary Syndromes
Interventions:   Drug: Apixaban;   Drug: vitamin K antagonist;   Drug: Acetylsalicylic acid;   Other: Acetylsalicylic acid placebo
Sponsors:   Bristol-Myers Squibb;   Pfizer;   Duke Clinical Research Institute
Not yet recruiting - verified April 2015

COcoa Supplement and Multivitamin Outcomes Study

Conditions:   Cardiovascular Disease;   Cancer
Interventions:   Dietary Supplement: Cocoa extract;   Dietary Supplement: Multivitamin;   Dietary Supplement: Cocoa extract placebo;   Dietary Supplement: Multivitamin placebo
Sponsors:   Brigham and Women's Hospital;   Fred Hutchinson Cancer Research Center;   Mars, Inc.;   Pfizer
Not yet recruiting - verified April 2015

Pilot Study Using an NMDA Antagonist to Modulate Transcranial Direct Current Stimulation (tDCS) Effects on Sensory Discrimination

Condition:   Schizophrenia
Interventions:   Device: Direct Current Stimulation;   Drug: Dextromethorphan
Sponsor:   University of Ottawa
Not yet recruiting - verified April 2015

Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension

Condition:   Hypertension
Intervention:   Drug: Trimethaphan
Sponsor:   Vanderbilt University
Recruiting - verified April 2015

Olive Leaf Extract as Part of a Healthy Lifestyle in the Reduction of Blood Pressure

Condition:   Pre Hypertension
Interventions:   Dietary Supplement: Olive leaf extract;   Dietary Supplement: Placebo
Sponsor:   University of Reading
Not yet recruiting - verified April 2015

Researches of Retinal Artery Lesions and Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   Capital Medical University
Active, not recruiting - verified April 2015

Apixaban for Treatment of Embolic Stroke of Undetermined Source

Condition:   Embolic Stroke
Interventions:   Drug: Apixaban;   Drug: Aspirin
Sponsor:   University Hospital Tuebingen
Not yet recruiting - verified April 2015

SONOlysis in Prevention of Brain InfaRctions During Internal Carotid Endarterectomy

Condition:   Internal Carotid Artery Stenosis
Intervention:   Device: sonolysis
Sponsors:   University Hospital Ostrava;   Military University Hospital, Prague;   Vitkovice Hospital, Ostrava;   Masaryk Hospital, Usti nad Labem;   České Budějovice Hospital;   University Hospital Hradec Kralove;   University Hospital Plzen, Plzen;   County Hospital Liberec, Liberec
Not yet recruiting - verified April 2015

Vascular Ultrasound Screening in Patients With Ischemic Cerebrovascular Disease: a Multi-center Registry Study

Condition:   Stroke
Intervention:  
Sponsors:   Xuanwu Hospital, Beijing;   The First Affiliated Hospital of Shanxi Medical University;   Liaocheng Brains Hospital;   Tianjin Huanhu Hospital;   Baotou City Central Hospital;   First Hospital of Jilin University;   First Affiliated Hospital of Harbin Medical University;   First Hospital of China Medical University;   LanZhou University;   First Affiliated Hospital of Xinjiang Medical University;   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School;   The First Affiliated Hospital of Soochow University;   Anhui Provincial Hospital;   Guangdong Provincial Hospital of Traditional Chinese Medicine;   Zhuhai  People's Hospital;   Fujian Provincial Hospital;   Mianyang Central Hospital;   The Second Affiliated Hospital of Kunming Medical University;   Brains Hospital of Hunan Province;   Henan Provincial Hospital;   Luoyang Central Hospital Affiliated to Zhengzhou University;   National Health and Family Planning Commission Stroke Prevention Engineering Committee
Not yet recruiting - verified March 2015

CRIC-Visceral Adiposity and Physical Fitness in Chronic Kidney Disease

Conditions:   Renal Insufficiency, Chronic;   Obesity
Intervention:  
Sponsors:   The Cleveland Clinic;   University of Pennsylvania;   Case Western Reserve University;   University of Michigan;   University of Illinois at Chicago;   University of Maryland;   MetroHealth Medical Center
Recruiting - verified April 2015

Open Label Study of Single Agent Oral RG7388 in Patients With Polycythemia Vera and Essential Thrombocythemia

Conditions:   Polycythemia Vera;   Essential Thrombocythemia
Interventions:   Drug: RG7388;   Drug: Pegasys
Sponsors:   John Mascarenhas;   Genentech, Inc.;   Roche Pharma AG
Recruiting - verified April 2015

Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: Tenecteplase;   Drug: Tissue Plasminogen Activator
Sponsors:   Neuroscience Trials Australia;   The Florey Institute of Neuroscience and Mental Health
Recruiting - verified April 2015

Fluid Responsiveness in the Postoperative Patient: a Prospective Study

Condition:   Actual Impaired Fluid Volume
Intervention:   Drug: Fluid challenge (250 ml Lactated Ringer's solution)
Sponsor:   McGill University Health Center
Not yet recruiting - verified April 2015

Renal Denervation Using the Vessix Renal Denervation System for the Treatment of Hypertension (REDUCE HTN:REINFORCE)

Condition:   Hypertension
Interventions:   Device: Renal Denervation (Vessix);   Device: Renal Angiography
Sponsor:   Boston Scientific Corporation
Enrolling by invitation - verified April 2015

Immediate Versus Delayed Invasive Intervention for Non-STEMI Patients

Condition:   Myocardial Infarction
Interventions:   Procedure: Immediate invasive intervention;   Procedure: Delayed invasive intervention;   Device: Coronary artery stenting
Sponsor:   Clinical Centre of Serbia
Active, not recruiting - verified April 2015

Robotic Therapy and Transcranial Direct Current Stimulation in Patients With Stroke

Condition:   Stroke
Interventions:   Device: Robotic Therapy;   Device: Active tDCS;   Device: Sham tDCS;   Other: Physical Therapy;   Other: Occupational Therapy
Sponsors:   University of Sao Paulo General Hospital;   Conselho Nacional de Desenvolvimento Científico e Tecnológico
Not yet recruiting - verified December 2014

CardiOvascular Risk and idEntificAtion of Potential High-risk Population in Acute Myocardial Infarction

Conditions:   Long-term Major Cardiovascular Events;   Myocardial Infarction;   Percutaneous Coronary Intervention
Interventions:   Device: Percutaneous coronary intervention;   Device: Percutaneous coronary intervention
Sponsors:   Kiyuk Chang;   The Catholic University of Korea;   Chonnam National University
Completed - verified April 2015

Altering Activation Patterns Post-stroke

Conditions:   Stroke;   Muscle Spasticity;   Hemiparesis
Interventions:   Drug: Cyproheptadine;   Drug: Placebo for Cyproheptadine;   Other: Active Movement Practice (AMP);   Other: Passive Cyclical Stretching
Sponsors:   Rehabilitation Institute of Chicago;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Not yet recruiting - verified April 2015

Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects

Condition:   Familial Frontotemporal Dementia
Intervention:  
Sponsors:   Mayo Clinic;   National Institute on Aging (NIA);   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified April 2015

Atherosclerotic Plaque Characteristics Associated With a Progression Rate of the Plaque in Carotids and a Risk of Stroke

Condition:   Carotid Artery Plaque
Intervention:  
Sponsors:   University Hospital Ostrava;   General Teaching Hospital, Prague;   Charles University, Czech Republic;   Palacky University
Recruiting - verified April 2015

Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism (RESCUE)-Japan RCT

Condition:   Ischemic Stroke
Interventions:   Procedure: Rescue endovascular therapy;   Procedure: No endovascular therapy
Sponsor:   Shinichi Yoshimura
Recruiting - verified April 2015

Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism (RESCUE)-Japan Registry 2

Condition:   Ischemic Stroke
Intervention:   Procedure: endovascular treatment
Sponsor:   Hyogo College of Medicine
Recruiting - verified April 2015

Weight Loss Referral for Healthier Survivorship in Obese Stage I-II Endometrial Cancer Survivors or Atypical Hyperplasia

Conditions:   Complex Endometrial Hyperplasia With Atypia;   Stage IA Uterine Corpus Cancer;   Stage IB Uterine Corpus Cancer;   Stage II Uterine Corpus Cancer
Interventions:   Behavioral: Weight Loss Specialist;   Other: Quality-of-Life Assessment;   Other: Medical Chart Review
Sponsors:   Case Comprehensive Cancer Center;   National Cancer Institute (NCI)
Recruiting - verified April 2015

Robot-assisted Gait Training on Mobility in Severely Disabled Multiple Sclerosis Patients

Condition:   Multiple Sclerosis
Interventions:   Device: Robot-assisted gait training;   Other: Conventional therapy
Sponsors:   University Hospital of Ferrara;   Regione Emilia-Romagna;   Università degli Studi di Ferrara
Recruiting - verified April 2015

Effect Of Early C-PAP Treatment For Sleep Apnea On Rehabilitation Of Stroke Patients

Conditions:   Sleep Apnea;   Stroke
Interventions:   Device: Watchpat;   Device: CPAP
Sponsor:   Soroka University Medical Center
Not yet recruiting - verified April 2015

"In Vivo" Comparison in Human Carotid Atherosclerosis: Plaque Neovascularization

Conditions:   Carotid Artery Disease;   Plaque Neovascularization
Interventions:   Other: Contrast enhanced ultrasound of the carotid plaque;   Other: Dynamic contrast-enhanced carotid plaque MRI
Sponsor:   Ospedale San Giovanni Bellinzona
Recruiting - verified April 2015

Outcome After Coronary Artery Bypass Grafting

Conditions:   Coronary Artery Disease;   Myocardial Infarction;   Angina Pectoris
Intervention:   Procedure: Coronary artery bypass surgery
Sponsors:   University of Oulu;   Universita di Verona;   Ospedali Riuniti Trieste;   University of Catania;   University of Leicester;   Centre Hospitalier Universitaire de Besancon;   Karolinska Institutet;   San Camillo Hospital, Rome;   Rennes University Hospital;   S. Anna Hospital;   Paracelsus Medical University;   Second University of Naples;   University of Parma
Recruiting - verified April 2015

RuSsian RegisTry of Acute CoronaRy SyndromE TreAtMent and Approach in Dual Antiplatelet Therapy

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified April 2015

Flow Mediated Dilation in Response to Black Tea

Condition:   Vascular Function
Interventions:   Other: Tea;   Other: Placebo
Sponsors:   Unilever R&D;   King's College London
Recruiting - verified March 2015

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified April 2015

The General Use of Robots in Stroke Recovery: the Anklebot

Condition:   Stroke
Intervention:   Device: MIT Anklebot
Sponsor:   North Shore Long Island Jewish Health System
Recruiting - verified April 2015

Pilot Study to Examine the Use of Rivaroxaban After Angioplasty for Critical Limb Ischemia

Condition:   Critical Limb Ischemia
Interventions:   Drug: rivaroxaban plus aspirin;   Drug: clopidogrel plus aspirin
Sponsors:   Ottawa Hospital Research Institute;   The Ottawa Hospital
Recruiting - verified April 2015

Enhanced Diagnostics for Early Detection of Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Device: ECG
Sponsor:   University Hospital, Basel, Switzerland
Recruiting - verified April 2015

Evaluating Anodal tDCS Preceding Aphasia Therapy

Conditions:   Stroke;   Aphasia
Intervention:   Device: transcranial direct current stimulation
Sponsor:   North Shore Long Island Jewish Health System
Recruiting - verified April 2015

Occult Paroxysmal Atrial Fibrillation in Non-Cryptogenic Ischemic Stroke

Condition:   Ischemic Stroke
Intervention:   Device: Reveal LINQ Insertable Cardiac Monitor
Sponsor:   North Shore Long Island Jewish Health System
Recruiting - verified April 2015

Imaging Collaterals in Acute Stroke (iCAS)

Condition:   Stroke, Acute
Intervention:  
Sponsors:   Stanford University;   Swedish Medical Center;   University of Pittsburgh
Recruiting - verified April 2015

Monitoring Everyday Life Motor Activity in Children

Condition:   Neurologic Disorders
Intervention:  
Sponsors:   Rob Labruyere;   Children's Research Center, Zurich
Recruiting - verified April 2015

Canadian Alliance for Healthy Hearts and Minds

Condition:   Cardiovascular Diseases
Intervention:   Other: MRI
Sponsor:   Montreal Heart Institute
Recruiting - verified April 2015

AOP2014 in Patients With Polycythemia Vera Who Previously Participated in the PROUD-PV Study.

Condition:   Polycythemia Vera
Intervention:   Drug: Pegylated-Proline-interferon alpha-2b
Sponsors:   AOP Orphan Pharmaceuticals AG;   PharmaEssentia (Co-Sponsor for USA)
Recruiting - verified April 2015

Critical Periods After Stroke Study (CPASS)

Conditions:   Stroke;   Brain Infarction;   Brain Ischemia;   Cerebral Infarction;   Cerebrovascular Disorders
Interventions:   Behavioral: Early Intensive upper extremity motor training;   Behavioral: Sub-acute intensive upper extremity motor training;   Behavioral: Chronic intensive upper extremity motor training
Sponsors:   MedStar National Rehabilitation Network;   Georgetown University;   University of Wisconsin, Madison;   The Catholic University of America;   Medstar Research Institute
Recruiting - verified April 2015

Active Surveillance Research Program for the Assessment of the Safety and the Effectiveness of Linagliptin

Condition:   Diabetes Mellitus, Type 2
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

Efficacy of Levetiracetam in Oromandibular and Cranial Dystonia

Conditions:   Oromandibular Dystonia;   Cranial Dystonia
Intervention:   Drug: Levetiracetam
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Proposed Single Center IDE: Feasibility of Endovascular Repair Of Ascending Aortic Pathologies

Conditions:   Aortic Dissection;   Intramural Hematoma;   Penetrating Ulcer;   Pseudoaneurysm
Intervention:   Device: Endovascular repair with Valiant PS-IDE Stent Graft
Sponsor:   Rodney A. White, M.D.
Recruiting - verified July 2014

Intramuscular Oxytocics: A Comparison Study of Intramuscular Carbetocin, Syntocinon and Syntometrine for the Third Stage of Labour Following Vaginal Birth

Condition:   Post Partum Haemorrhage
Interventions:   Drug: Carbetocin;   Drug: Syntocinon;   Drug: Syntometrine
Sponsors:   North Bristol NHS Trust;   Ferring Pharmaceuticals;   University of Bristol;   University of the West of England;   Royal United Hospital Bath NHS Trust;   Gloucester Hospitals NHS Trust;   University Hospitals Bristol NHS Foundation Trust
Recruiting - verified August 2014

Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage (The PATCH Study)

Conditions:   Wounds and Injuries;   Acute Coagulopathy
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsors:   National Trauma Research Institute;   National Health and Medical Research Council, Australia
Recruiting - verified April 2015

Gait Enhancing Mobile Shoe for Stroke Rehabilitation

Condition:   Stroke
Intervention:   Device: wearing the GEMS
Sponsors:   University of South Florida;   Moterum, LLC
Recruiting - verified April 2015

Efficacy and Security of an Endovascular Treatment as First Choice Procedure Compared With a Standard Intravenous Thrombolytic Therapy Treatment for Patients With Acute Ischemic Stroke Within 4.5 Hours After Onset

Condition:   Acute Ischaemic Stroke
Interventions:   Procedure: EVT (endovascular treatment );   Procedure: IVT (intravenous thrombolytic therapy)
Sponsor:   Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Active, not recruiting - verified June 2014

Vascular Dysfunction in Paediatric IBD

Conditions:   Inflammatory Bowel Disease;   Crohn Disease;   Ulcerative Colitis
Intervention:  
Sponsors:   Great Ormond Street Hospital for Children NHS Foundation Trust;   National Institute for Health Research, United Kingdom
Recruiting - verified April 2015

Early Post-marketing Study of Eliquis (Apixaban)

Condition:   Non-valvular Atrial Fibrillation (NVAF)
Intervention:   Drug: Apixaban
Sponsor:   Bristol-Myers Squibb
Active, not recruiting - verified February 2015

VTEval Project - Prospective Cohort Studies to Evaluate and Improve Diagnostics, Management Strategies and Risk Stratification in VTE

Conditions:   Venous Thromboembolism (VTE);   Deep Vein Thrombosis (DVT);   Pulmonary Embolism (PE)
Intervention:  
Sponsor:   Johannes Gutenberg University Mainz
Recruiting - verified April 2015

Ascertainment of EMR-based Clinical Covariates Among Patients Receiving Oral and Non-insulin Injected Hypoglycemic Therapy

Condition:   Diabetes Mellitus, Type 2
Intervention:  
Sponsor:   Boehringer Ingelheim
Completed - verified April 2015

A Blinded Study to Evaluate Effect on Atrial Fibrillation Burden in Patients With Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Interventions:   Drug: BMS-919373;   Drug: Placebo (Matching with BMS-919373)
Sponsor:   Bristol-Myers Squibb
Recruiting - verified April 2015

Preload Dependency by Impedance Cardiography After Cardiac Surgery

Condition:   Cardiac Surgery With Extracorporeal Circulation
Intervention:   Device: Impedance cardiography Physioflow ®
Sponsor:   University Hospital, Strasbourg, France
Recruiting - verified April 2015

A Self-efficacy Enhancing Stroke Self-management Program for Community-dwelling Stroke Survivors

Condition:   Stroke
Interventions:   Behavioral: Stroke self-management program;   Behavioral: Usual care
Sponsor:   Queensland University of Technology
Recruiting - verified April 2015

A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients

Conditions:   Heart Failure;   Respiratory Insufficiency;   Stroke Acute;   Infectious Diseases;   Rheumatic Diseases
Interventions:   Drug: Rivaroxaban, 10 mg;   Drug: Rivaroxaban, 7.5 mg;   Drug: Placebo
Sponsor:   Janssen Research & Development, LLC
Recruiting - verified April 2015

Combined Bronchodilators in Chronic Obstructive Pulmonary Disease and the Risk of Adverse Cardio-pulmonary Events

Condition:   Pulmonary Disease, Chronic Obstructive
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified April 2015

Speech Therapy for Aphasia: Comparing Two Treatments

Condition:   Stroke
Interventions:   Behavioral: Speech therapy for aphasia: comparing two treatments;   Behavioral: Semantic Feature Analysis therapy
Sponsors:   Department of Veterans Affairs;   Portland State University;   University of Washington
Recruiting - verified April 2015

Niche Trial: Navigated Inhibitory rTMS to Contralesional Hemisphere Trial

Condition:   Stroke
Interventions:   Device: NBS-guided rTMS;   Device: Sham rTMS
Sponsor:   Nexstim Ltd
Recruiting - verified April 2015

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy;   Device: Carotid stenting
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions

Conditions:   Chronic Troublesome Sialorrhea;   Parkinson's Disease;   Post-stroke;   Traumatic Brain Injury
Interventions:   Drug: IncobotulinumtoxinA (100 Units);   Drug: IncobotulinumtoxinA (75 Units);   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Recruiting - verified April 2015

Sequential Expansion of Comparative Effectiveness of Anticoagulants

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

Edoxaban vs. Warfarin in Subjects Undergoing Cardioversion of Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Drug: edoxaban;   Drug: Enoxaparin;   Drug: Warfarin
Sponsors:   Daiichi Sankyo Inc.;   Covance;   Quintiles
Recruiting - verified April 2015

Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic VTE(Venous Thromboembolism)

Conditions:   Pulmonary Embolism;   Thromboembolism;   Thrombosis;   Venous Thrombosis;   Venous Thromboembolism
Interventions:   Drug: BAY 59-7939;   Drug: BAY 59-7939;   Drug: ASA
Sponsor:   Bayer
Recruiting - verified April 2015

Study Of The Blood Thinner, Apixaban, For Patients Who Have An Abnormal Heart Rhythm (Atrial Fibrillation) And Expected To Have Treatment To Put Them Back Into A Normal Heart Rhythm (Cardioversion)

Condition:   Atrial Fibrillation
Interventions:   Drug: Apixaban;   Drug: Parenteral heparin and/or oral Vitamin K antagonist
Sponsors:   Pfizer;   Bristol-Myers Squibb
Recruiting - verified April 2015

Understanding the Role of Autoimmune Disorders on the Initial Presentation of Cardiovascular Disease

Conditions:   Myocardial Infarction;   Ischemic Stroke;   Stroke;   Subarachnoid Haemorrhage;   Venous Thrombosis;   Transient Ischemic Attack;   Stable Angina Pectoris;   Unstable Angina;   Heart Failure;   Peripheral Arterial Disease;   Abdominal Aortic Aneurysm
Intervention:   Other: No intervention
Sponsors:   University College, London;   Wellcome Trust;   National Institute for Health Research, United Kingdom
Active, not recruiting - verified April 2015

Trevo® Retriever Registry Post Market Surveillance

Condition:   Ischemic Stroke
Intervention:  
Sponsor:   Stryker Neurovascular
Recruiting - verified April 2015

Post Market Surveillance Study of the Wingspan Stent System

Condition:   Intracranial Atherosclerosis
Intervention:   Device: Wingspan Stent System
Sponsor:   Stryker Neurovascular
Recruiting - verified April 2015

Effects of Novel Game Rehabilitation System on Upper Extremity Function of Patients With Stroke

Condition:   Stroke
Interventions:   Device: E-glove system;   Procedure: Conventional occupational therapy
Sponsors:   National Rehabilitation Center, Seoul, Korea;   Ministry of Trade, Industry & Energy, Republic of Korea;   National IT Industry Promotion Agency, Republic of Korea
Active, not recruiting - verified April 2015

The Efficacy of Bariatric Surgery Compared to Medical Therapy in Controlling Type2 Diabetes Mellitus in Patients With Non Morbid Obesity.

Conditions:   Overweight;   Diabetes Type 2
Interventions:   Procedure: Laparoscopic Sleeve Gastrectomy;   Procedure: Laparoscopic Roux-en-Y Gastric Bypass;   Drug: Advanced Medical Therapy
Sponsor:   Hadassah Medical Organization
Recruiting - verified February 2015

Open-Label, Dose-Escalating Study to Assess Safety, Tolerability, Efficacy, PK and PD of RP103 in Children With Inherited Mitochondrial Disease

Condition:   Inherited Mitochondrial Disease, Including Leigh Syndrome
Intervention:   Drug: Cysteamine Bitartrate Delayed-release Capsules (RP103)
Sponsor:   Raptor Pharmaceuticals Inc.
Recruiting - verified April 2015

Ischemia Care Biomarkers of Acute Stroke Etiology (BASE)

Conditions:   Ischemic Stroke;   Atrial Fibrillation;   Transient Ischemic Attacks;   Transient Cerebrovascular Events
Intervention:   Other: Biomarker blood draw
Sponsor:   Ischemia Care LLC
Recruiting - verified April 2015

[SOCRATES -Acute Stroke Or Transient IsChaemic Attack TReated With Aspirin or Ticagrelor and Patient OutcomES]

Conditions:   Acute Ischaemic Stroke;   Transient Ischaemic Attack.
Interventions:   Drug: ticagrelor;   Drug: Acetylsalicylic acid (ASA)
Sponsor:   AstraZeneca
Recruiting - verified April 2015

A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Ticagrelor 90 mg;   Drug: Ticagrelor placebo
Sponsor:   AstraZeneca
Recruiting - verified April 2015

Cardiovascular Outcomes Following Treatment With Ertugliflozin in Participants With Type 2 Diabetes Mellitus and Established Vascular Disease (MK-8835-004)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Ertugliflozin;   Drug: Placebo
Sponsors:   Merck Sharp & Dohme Corp.;   Pfizer
Recruiting - verified April 2015

ISCHEMIA-Chronic Kidney Disease Trial

Conditions:   Cardiovascular Diseases;   Coronary Artery Disease;   Heart Diseases;   Myocardial Ischemia;   Kidney Disease;   End Stage Renal Failure on Dialysis
Interventions:   Procedure: Cardiac Catheterization;   Procedure: Coronary Artery Bypass Graft Surgery;   Procedure: Percutaneous Coronary Intervention;   Behavioral: Lifestyle;   Drug: Medication
Sponsors:   New York University School of Medicine;   New York University;   National Heart, Lung, and Blood Institute (NHLBI);   Vanderbilt University;   Albany Stratton VA Medical Center;   East Carolina University;   Duke University;   Stanford University;   Harvard University;   Columbia University
Recruiting - verified April 2015

Single Session Percutaneous Mechanical Thrombectomy for the Treatment of Ilio-femoral Deep Vein Thrombosis: A Preliminary Evaluation

Conditions:   Deep Vein Thrombosis;   Venous Thromboembolism
Intervention:   Device: Thrombectomy
Sponsor:   Ottawa Hospital Research Institute
Terminated - verified April 2015

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified April 2015

A Clinical Trial to Evaluate the HeartWare® Ventricular Assist System (ENDURANCE SUPPLEMENTAL TRIAL)

Condition:   Chronic Heart Failure
Interventions:   Device: HeartWare® VAS;   Device: Control LVAD
Sponsor:   HeartWare, Inc.
Recruiting - verified April 2015

Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Hyperlipidemia or Mixed Dyslipidemia at Risk of Cardiovascular Events

Condition:   Hyperlipidemia
Interventions:   Drug: Bococizumab (PF-04950615; RN316);   Other: Placebo
Sponsor:   Pfizer
Recruiting - verified April 2015

A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Events

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: insulin degludec;   Drug: insulin glargine
Sponsor:   Novo Nordisk A/S
Active, not recruiting - verified April 2015

GLORIA-AF Registry Program (Phase II/III)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

Study of GSK1278863 to Reduce Ischemic Events in Patients Undergoing Thoracic Aortic Aneurysm Repair

Condition:   Surgical Procedures
Interventions:   Drug: GSK1278863;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Completed - verified April 2015

Xenon as an Adjuvant to Propofol Anaesthesia in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery.

Conditions:   Coronary Artery Disease;   Anesthesia
Interventions:   Drug: Xenon and propofol;   Drug: propofol
Sponsor:   Universitaire Ziekenhuizen Leuven
Completed - verified April 2015

The Singapore Tele-technology Aided Rehabilitation in Stroke (STARS) Study

Condition:   Stroke
Intervention:   Other: Tele-rehabilitation
Sponsors:   National University, Singapore;   Singapore Millennium Foundation;   Singapore General Hospital;   Ang Mo Kio Thye Hua Kwan Hospital
Recruiting - verified April 2015

Resolute Integrity US Extended Length Sub-Study(RI-US XL)

Condition:   Coronary Artery Disease
Intervention:   Device: Resolute Integrity Stent
Sponsor:   Medtronic Vascular
Recruiting - verified April 2015

ENDOvascular Interventions With AngioMAX: The ENDOMAX Trial

Condition:   Peripheral Endovascular Interventions
Intervention:   Drug: Bivalirudin
Sponsor:   The Medicines Company
Recruiting - verified July 2014

Non-interventional Local Study on Prescription Behavior of Anticoagulation Therapy in Secondary Stroke Prevention in Atrial Fibrillation Patients

Conditions:   Stroke,;   Embolism
Intervention:   Other: Rivaroxaban ( Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified April 2015

A Study of Movement Disorders Using the QMAT At-Home Testing Device

Conditions:   Movement Disorders;   Parkinson's Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified April 2015

Electrical Impedance Myography: Exploratory Studies in Healthy People and People With Neuromuscular Disorders

Conditions:   Neuromuscular Disease;   Motor Neuron Disease;   Inherited Neuromuscular Conditions;   Inherited Neuropathies
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2015

A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure

Conditions:   Heart Failure;   Coronary Artery Disease
Interventions:   Drug: Rivaroxaban;   Drug: Placebo;   Other: Standard of care for heart failure and coronary artery disease
Sponsors:   Janssen Research & Development, LLC;   Bayer
Recruiting - verified April 2015

Stroke Therapy, Education, Prevention: Telemedicine Outpatient Initiative Trial

Condition:   Stroke
Interventions:   Other: Telemedicine;   Other: Clinic
Sponsor:   Oregon Health and Science University
Recruiting - verified April 2015

Vein of Marshall Ethanol Infusion for Persistent Atrial Fibrillation FIBRILLATION

Conditions:   Ventricular Tachycardia;   Atrial Fibrillation
Interventions:   Drug: Ethanol;   Procedure: Ablation
Sponsors:   The Methodist Hospital System;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 2015

Nutrition Blood Outcomes Following Tocotrienol N2B

Condition:   Stroke
Interventions:   Dietary Supplement: Tocotrienol Capsules;   Other: Placebo Vehicle
Sponsors:   Ohio State University;   Malaysian Palm Oil Board
Recruiting - verified April 2015

A Very Early Rehabilitation Trial

Condition:   Stroke
Interventions:   Other: Standard Care + VEM;   Other: Standard care
Sponsors:   Neuroscience Trials Australia;   Singhealth Foundation;   Chest, Heart and Stroke Association Scotland;   Northern Ireland Chest Heart and Stroke;   The Stroke Association - UK;   National Institute for Health Research, United Kingdom
Completed - verified April 2015

ALdosterone Antagonist Chronic HEModialysis Interventional Survival Trial

Condition:   End Stage Renal Failure on Dialysis
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   University Hospital, Brest;   Central Hospital, Nancy, France;   Institut National de la Santé Et de la Recherche Médicale, France
Recruiting - verified April 2015

A Randomized, Non-inferiority Clinical Trial of CVA Telerehabilitation Treatments - TelePhysioTaiChi

Condition:   Stroke
Intervention:   Behavioral: Tai Chi based exercise program
Sponsors:   Université de Sherbrooke ;   Université de Montréal;   University of Toronto
Recruiting - verified April 2015

Omega-3 Fatty Acids in Elderly Patients With Acute Myocardial Infarction

Conditions:   Myocardial Infarction;   Heart Failure;   Myocardial Revascularization;   Atrial Fibrillation
Interventions:   Drug: Pikasol;   Other: Corn oil
Sponsors:   Oslo University Hospital;   University Hospital, Akershus;   Asker & Baerum Hospital
Recruiting - verified October 2014

Anticoagulant Utilization Pattern

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

A Study Exploring Two Strategies of Rivaroxaban (JNJ39039039; BAY-59-7939) and One of Oral Vitamin K Antagonist in Patients With Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention

Conditions:   Atrial Fibrillation;   Percutaneous Coronary Intervention
Interventions:   Drug: rivaroxaban 2.5 mg;   Drug: rivaroxaban 15 mg;   Drug: rivaroxaban 10 mg;   Drug: aspirin (ASA);   Drug: vitamin K antagonist (VKA);   Drug: clopidogrel;   Drug: prasugrel;   Drug: ticagrelor
Sponsors:   Janssen Scientific Affairs, LLC;   Bayer
Recruiting - verified April 2015

Occupational Performance Coaching for Stroke Survivors

Condition:   Stroke
Interventions:   Other: OPC-Stroke;   Other: Usual care
Sponsors:   Ottawa Hospital Research Institute;   University of Ottawa
Active, not recruiting - verified April 2015

A New Multi-parameter Neuromonitoring System to Save Patients' Lives in Stroke and Brain Injury

Conditions:   Subarachnoid Hemorrhage;   Optical Imaging
Intervention:   Device: NeMo Patch and NeMo Probe
Sponsors:   NeMoDevices AG;   Medical University of Graz;   University of Zurich
Recruiting - verified April 2015

Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy

Condition:   Cerebral Amyloid Angiopathy
Interventions:   Biological: Ponezumab;   Other: placebo
Sponsor:   Pfizer
Active, not recruiting - verified April 2015

A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD)

Condition:   Sickle Cell Disease
Interventions:   Drug: Prasugrel;   Drug: Placebo
Sponsors:   Eli Lilly and Company;   Daiichi Sankyo Inc.
Recruiting - verified April 2015

Not Invasive Monitoring of Pleural Drainage

Condition:   Pleural Effusion
Intervention:   Device: Body Bioimpedance Sensor
Sponsor:   RWTH Aachen University
Completed - verified April 2015

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk

Condition:   Dyslipidemia
Interventions:   Biological: Evolocumab (AMG 145);   Other: Placebo;   Drug: Effective statin therapy
Sponsor:   Amgen
Recruiting - verified April 2015

A Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease

Condition:   Peripheral Artery Disease
Interventions:   Drug: Ticagrelor;   Drug: Clopidogrel
Sponsor:   AstraZeneca
Active, not recruiting - verified April 2015

Examining How Motor Rehabilitation Promotes Brain Reorganization Following Stroke, an MRI Study

Conditions:   Stroke;   Hemiparesis
Intervention:   Behavioral: CI therapy
Sponsor:   Lynne Gauthier , PhD
Recruiting - verified April 2015

Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development

Condition:   Spinal Muscular Atrophy (SMA)
Intervention:  
Sponsors:   Ohio State University;   National Institute of Neurological Disorders and Stroke (NINDS);   Families of Spinal Muscular Atrophy;   Massachusetts General Hospital;   University of Iowa
Active, not recruiting - verified April 2015

Robots Paired With tDCS in Stroke Recovery

Condition:   Stroke
Interventions:   Device: Transcranial Direct Current Stimulation (tDCS);   Device: Placebo sham
Sponsor:   North Shore Long Island Jewish Health System
Recruiting - verified April 2015

The CHAPTER II Study - Congenital Heart Adolescents Participating in Transition Evaluation Research

Condition:   Congenital Heart Disease
Interventions:   Behavioral: Educational;   Behavioral: Self management
Sponsors:   University of Alberta;   Heart and Stroke Foundation of Canada
Active, not recruiting - verified April 2015

The Role of HMGB-1 in Chronic Stroke

Conditions:   Cerebrovascular Accident;   Cerebral Stroke;   Stroke, Acute
Intervention:  
Sponsor:   North Shore Long Island Jewish Health System
Recruiting - verified April 2015

STOP-AUST: The Spot Sign and Tranexamic Acid On Preventing ICH Growth - AUStralasia Trial

Conditions:   Intracerebral Haemorrhage;   Stroke
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsor:   Neuroscience Trials Australia
Recruiting - verified September 2014

Contralaterally Controlled FES of Arm & Hand for Subacute Stroke Rehabilitation

Conditions:   Stroke;   Hemiparesis;   Hemiplegia
Intervention:   Device: Electrical stimulator
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified April 2015

Danhong Injection in the Treatment of Acute Ischemic Stroke

Condition:   Acute Stroke
Interventions:   Drug: Danhong injection;   Procedure: Standard medical care;   Drug: placebo
Sponsors:   China  Academy of Chinese Medical Sciences;   China: State Food and Drug Administration
Recruiting - verified April 2015

Balance Rehabilitation With Sensory Recalibration After Stroke

Condition:   Left-sided Hemiplegia Affecting Dominant Side as Late Effect of Cerebrovascular Accident
Interventions:   Other: Cervical vibration;   Other: Prism adaptation;   Other: Conventional rehabilitation
Sponsor:   Rennes University Hospital
Recruiting - verified April 2015

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab SAR236553 (REGN727)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Other: placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified April 2015

An Evaluation of the Commercially Available Medtronic Resolute Integrity Zotarolimus-Eluting Coronary Stent System

Condition:   Coronary Artery Disease
Intervention:   Procedure: Medtronic Resolute Integrity Zotarolimus-Eluting Coronary Stent System (Resolute Integrity Stent)
Sponsor:   Medtronic Vascular
Active, not recruiting - verified April 2015

Hybrid AF -- A Prospective Registry

Condition:   Atrial Fibrillation
Intervention:   Procedure: Standard of Care
Sponsors:   Dhanunjaya Lakkireddy, MD, FACC;   Estech
Withdrawn - verified April 2015

COAPT Clinical Trial

Conditions:   Mitral Regurgitation;   Mitral Valve Regurgitation
Intervention:   Device: MitraClip System
Sponsors:   Evalve;   Abbott Vascular
Recruiting - verified April 2015

Self-directed Titrated Transdermal Nicotine Patch Versus Standard Treatment for Smoking Cessation

Condition:   Smoking Cessation
Interventions:   Drug: NicoDerm Patch;   Drug: Nicorette Inhaler
Sponsors:   Ottawa Heart Institute Research Corporation;   Heart and Stroke Foundation of Ontario
Completed - verified April 2015

Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsor:   Bayer
Completed - verified April 2015

A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Brilinta

Condition:   Acute Coronary Syndromes
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified April 2015

Stimulation With Wire Leads to Restore Cough

Conditions:   Spinal Cord Injuries;   Spinal Cord Diseases;   Paralysis;   Central Nervous System Diseases;   Cough;   Trauma, Nervous System;   Wounds and Injuries
Interventions:   Device: Expiratory muscle stimulator;   Procedure: Implantation of device
Sponsors:   Case Western Reserve University;   MetroHealth Medical Center;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Pro-coagulant Markers and Anticoagulant Failure in Cancer Patients at Risk for Recurrence of Venous Thromboembolism

Conditions:   Venous Thromboembolism;   Deep-Vein Thrombosis;   Pulmonary Embolism;   Cancer
Intervention:  
Sponsors:   Ottawa Hospital Research Institute;   Heart and Stroke Foundation of Ontario
Active, not recruiting - verified April 2015

EXTEND (International): Extending the Time for Thrombolysis in Emergency Neurological Deficits (International)

Condition:   Stroke
Interventions:   Drug: Tissue Plasminogen Activator (Alteplase);   Drug: Placebo
Sponsors:   Neuroscience Trials Australia;   China Medical University Hospital
Recruiting - verified September 2014

Xarelto [SPAF] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban(Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified April 2015

Xarelto [SPAF-QOL] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban (Xarelto_ BAY59-7939)
Sponsor:   Bayer
Recruiting - verified April 2015

Music Therapy/Physical Therapy Intervention to Enhance Well-being and Functional Recovery Post-stroke

Condition:   Stroke With Hemiparesis
Intervention:   Other: Music & Physical Therapy
Sponsors:   New York University School of Medicine;   New York University
Active, not recruiting - verified April 2015

NUTRITION: Natural Tocotrienol Against Ischemic Stroke Event

Conditions:   Ischemic Stroke;   Transient Ischemic Attack (TIA)
Interventions:   Other: Vitamin E tocotrienol (TCT) capsules ; Low dose Aspirin;   Other: Placebo vehicle control
Sponsors:   Chandan K Sen;   Government of Malaysia
Recruiting - verified April 2015

Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.

Condition:   Smoking Cessation
Interventions:   Drug: placebo;   Drug: varenicline tartrate;   Drug: bupropion hydrochloride;   Drug: Nicotine Replacement Therapy Patch
Sponsor:   Pfizer
Recruiting - verified April 2015

Structurally Reorganizing Motor Cortex in Stroke Patients Through Hebbian-type Stimulation

Condition:   Stroke
Interventions:   Device: Repetitive Transcranial Magnetic Stimulation (rTMS);   Device: Sham stimulation
Sponsors:   Cathrin Buetefisch;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified April 2015

Role of Ipsilateral Motor Cortex in Executing Movements With Increasing Demand on Precision

Condition:   Stroke
Intervention:  
Sponsors:   Cathrin Buetefisch;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Training Dual-Task Walking After Stroke

Condition:   Stroke
Intervention:   Behavioral: Gait training
Sponsors:   University of North Carolina, Chapel Hill;   University of Arizona
Recruiting - verified April 2015

Botulinum Toxin for Pelvic Pain in Women With Endometriosis

Conditions:   Endometriosis;   Botulinum Toxin A;   Chronic Pelvic Pain;   Pelvic Muscle Spasms;   Quality of Life
Intervention:   Drug: Botuninum toxin A
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified April 2015

Efficiency Study Evaluating the Use of the PVAC Catheter Technology for Performing Ablation in Patients With Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Device: Radiofrequency Ablation Procedure;   Device: Radiofrequency Ablation Procedure
Sponsors:   Newmarket Electrophysiology Research Group Inc;   Medtronic
Recruiting - verified April 2015

Motor Cortex Stimulation for Chronic Neuropathic Pain

Conditions:   Neuropathic Pain;   Facial Pain;   Post-stroke Pain;   Brachial Plexus Avulsion;   Phantom Limb Pain of the Upper Extremities
Intervention:   Device: Motor Cortex Stimulation using SJM EonC Stimulator
Sponsor:   St. Jude Medical
Recruiting - verified April 2015

Cyclosporine and Prognosis in Acute Myocardial Infarction (MI) Patients

Condition:   ST Elevation Acute Myocardial Infarction
Interventions:   Drug: Injection of Cyclosporin;   Drug: Placebo;   Procedure: Echocardiography
Sponsor:   Hospices Civils de Lyon
Active, not recruiting - verified April 2015

Role of Cerebral Oximetry In Reducing Delirium After Complex Cardiac Surgery

Condition:   Cardiac Disease
Interventions:   Device: Cerebral oximetry monitor (The INVOS® Cerebral/Somatic Oximeter);   Other: An alarm threshold at 75% of the baseline rSO2 value
Sponsor:   University Health Network, Toronto
Active, not recruiting - verified April 2015

Extending the Time for Thrombolysis in Emergency Neurological Deficits - Intra-Arterial

Condition:   Ischemic Stroke
Interventions:   Device: Intra-arterial Clot Retrieval with Solitaire device;   Genetic: intravenous tissue plasminogen activator (tPA)
Sponsor:   Neuroscience Trials Australia
Terminated - verified December 2014

GLORIA-AF Registry Program - Second and Third Phases

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

Study of the Recovery of Muscle Function in the Arm/Hand After a Stroke

Conditions:   Stroke;   Hemiparesis
Interventions:   Other: Simultaneous Bimanual training;   Other: Conventional Occupational Therapy
Sponsors:   New York University School of Medicine;   Mount Sinai School of Medicine
Recruiting - verified April 2015

Study of Botulinum Toxin and Recovery of Hand Function After Stroke

Condition:   Stroke With Hemiparesis
Intervention:   Drug: Botulinum Toxin commonly known as BOTOX®
Sponsors:   New York University School of Medicine;   Allergan
Completed - verified April 2015

Medico-economic Evaluation of Preoperative Cerebral Oximetry Monitoring During Carotid Endarterectomy

Condition:   Internal Carotid Stenosis
Interventions:   Other: cerebral oximetry monitoring using INVOS™ and hemodynamic optimisation;   Other: standard cerebral monitoring and hemodynamic optimisation
Sponsors:   Nantes University Hospital;   Ministry of Health, France
Recruiting - verified April 2015

Interhemispheric Inhibitory Interactions

Condition:   Stroke
Intervention:   Other: continuous theta burst stimulation
Sponsor:   Canadian Institutes of Health Research  (CIHR)
Active, not recruiting - verified April 2015

Remote Ischemic Preconditioning in High Risk Cardiovascular Surgery Patients

Conditions:   Death;   Stroke;   Low Cardiac Output Syndrome;   Myocardial Infarction;   Renal Failure;   Pulmonary Failure
Interventions:   Other: Remote ischemic preconditioning stimulus;   Other: control
Sponsor:   Queen's University
Recruiting - verified April 2015

Current Clinical Practice in the Management of Atrial Fibrillation in Greece: the MANAGE-AF Study

Condition:   Atrial Fibrillation
Intervention:  
Sponsors:   Hellenic Cardiovascular Research Society;   Bayer
Completed - verified April 2015

ShuntCheck Versus Radionuclide in Evaluating Shunt Function in Symptomatic NPH Patients

Condition:   Hydrocephalus
Intervention:   Device: ShuntCheck test
Sponsors:   NeuroDx Development;   Sinai Hospital of Baltimore;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Evaluation of the Endeavor Resolute Zotarolimus-Eluting Coronary Stent System in a Real-World Patient Population in China

Conditions:   Ischemic Heart Disease;   Stenotic Coronary Lesion;   Cardiovascular Diseases;   Arteriosclerosis;   Coronary Artery Disease
Intervention:  
Sponsor:   Medtronic Vascular
Active, not recruiting - verified April 2015

Quantitative Imaging and Proton Spectroscopy in Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:   Other: Magnetic Resonance Imaging
Sponsors:   New York University School of Medicine;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

EXCEL Clinical Trial

Conditions:   Chronic Coronary Occlusion;   Unprotected Left Main Coronary Artery Disease;   Stent Thrombosis;   Vascular Disease;   Myocardial Ischemia;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Artery Disease;   Coronary Restenosis
Interventions:   Device: Percutaneous Coronary Intervention;   Procedure: CABG
Sponsor:   Abbott Vascular
Active, not recruiting - verified April 2015

Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH-II)

Condition:   Intracerebral Hemorrhage
Intervention:   Drug: Nicardipine hydrochloride
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Medical University of South Carolina;   National Institute of Neurological Disorders and Stroke (NINDS);   Johns Hopkins University;   University of Michigan
Recruiting - verified April 2015

Goal Directed Fluid Therapy in Free Flap Reconstructive Surgery

Condition:   Head and Neck Cancer
Intervention:   Other: Goal directed fluid management based on continuous monitoring of stroke volume
Sponsor:   University Health Network, Toronto
Completed - verified April 2015

Drug-Eluting Stents vs. Bare Metal Stents In Saphenous Vein Graft Angioplasty

Condition:   Saphenous Vein Graft Atherosclerosis
Interventions:   Device: Bare Metal Stent;   Device: Drug-Eluting Stent;   Drug: Blinded clopidogrel;   Drug: Placebo;   Drug: Thienopyridine (open-label)
Sponsor:   Department of Veterans Affairs
Recruiting - verified April 2015

Strategy for Adequate Blood Pressure Lowering in the Patients With Intracranial Atherosclerosis

Condition:   Brain Ischemia
Interventions:   Procedure: Aggressive BP lowering;   Procedure: modest blood pressure lowering
Sponsors:   Asan Medical Center;   Pfizer
Active, not recruiting - verified April 2015

Troponin T as Risk Stratification Tool in Peripheral Arterial Occlusive Disease

Condition:   Peripheral Arterial Occlusive Disease
Intervention:  
Sponsors:   Heart Center Bad Krozingen;   Johann Wolfgang Goethe University Hospitals
Completed - verified April 2015

Effectiveness Of A Program That Includes Counseling And Patient Support On Adherence To Treatment With Lipitor

Condition:   Medication Non-Adherence
Interventions:   Behavioral: No Patient Counseling;   Behavioral: Adherence Counseling
Sponsor:   Pfizer
Completed - verified December 2011

An Alternative to A Fixed Schedule In Management Of Prostate Cancer

Condition:   Prostate Cancer
Intervention:  
Sponsor:   University Health Network, Toronto
Completed - verified April 2015

The PREVENTS Trial: The Preventing Recurrent Events in Veterans Navigating Transient Ischemic Attack (TIA) or Stroke Trial

Conditions:   Stroke;   Transient Ischemic Attack
Interventions:   Behavioral: tailored intervention;   Behavioral: attention placebo
Sponsor:   Narrows Institute for Biomedical Research
Completed - verified April 2015

Navigated Transcranial Magnetic Stimulation in Monitoring Stroke Recovery

Condition:   Ischemic Stroke
Intervention:   Device: Navigated TMS examination
Sponsor:   Nexstim Ltd
Terminated - verified April 2015

Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial

Condition:   Ischemic Attack, Transient
Interventions:   Drug: Clopidogrel;   Drug: placebo
Sponsors:   University of California, San Francisco;   Neurological Emergencies Treatment Trials Network (NETT);   Medical University of South Carolina;   The EMMES Corporation
Recruiting - verified April 2015

Sub-study to Spinal Cord Stimulation to Restore Cough

Conditions:   Spinal Cord Injuries;   Spinal Cord Diseases;   Paralysis;   Central Nervous System Diseases;   Cough
Interventions:   Procedure: Spinal Cord Stimulation;   Device: Expiratory Muscle Stimulator
Sponsors:   Case Western Reserve University;   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified April 2015

Efficacy and Cost-Effectiveness of Cost-free Pharmacotherapy for Smoking Cessation for High-risk Smokers With Cerebrovascular Disease

Conditions:   Cerebrovascular Disorders;   Smoking Cessation
Interventions:   Drug: Cost-Free Pharmacotherapy Group;   Other: Prescription Only Group
Sponsors:   Ottawa Heart Institute Research Corporation;   Heart and Stroke Foundation of Ontario
Completed - verified April 2015

Impact of Statins on Cytokine Expression in Pneumonia

Conditions:   Community Acquired Pneumonia;   Cardiovascular Risk Factors
Interventions:   Drug: simvastatin;   Drug: Placebo
Sponsor:   The University of Texas Health Science Center at San Antonio
Withdrawn - verified April 2015

Preventing Recurrent Vascular Events in Patients With Stroke or Transient Ischemic Attack

Conditions:   Ischemic Stroke;   Transient Ischemic Attacks
Interventions:   Drug: Antihypertensive agents and lipid lowering therapy;   Other: Usual Care
Sponsors:   University of Alberta;   Heart and Stroke Foundation of Canada;   Alberta Heritage Foundation for Medical Research
Completed - verified April 2015

Extending the Time for Thrombolysis in Emergency Neurological Deficits

Condition:   Stroke
Interventions:   Drug: Tissue Plasminogen Activator (Alteplase);   Drug: Placebo
Sponsors:   Neuroscience Trials Australia;   Commonwealth Scientific & Industry Research Organisation;   Brain Research Institute;   University of Melbourne;   Melbourne Health
Recruiting - verified September 2014

Pilot Study of Bumetanide for Newborn Seizures

Condition:   Seizures
Intervention:   Drug: Bumetanide
Sponsors:   Soul, Janet , M.D.;   Citizens United for Research in Epilepsy;   Harvard Catalyst- Harvard Clinical and Translational Science Center;   Translational Research Program, Boston Children's Hospital;   Charles H. Hood Foundation;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Electrical Stimulation for Recovery of Hand Function in Chronic Stroke Survivors

Conditions:   Stroke;   Hemiparesis;   Hemiplegia
Intervention:   Device: Electrical stimulator
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting - verified April 2015

Neurobiological Principles Applied to the Rehabilitation of Stroke Patients

Condition:   Stroke
Interventions:   Drug: Sinemet, ritalin, amphetamine,  and placebo;   Device: Transcranial magnetic stimulation (TMS);   Other: Combined drug treatment and TMS
Sponsors:   Emory University;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2015

Neurotoxicity in Primary Central Nervous System Lymphoma (PCNSL): An International Observational Study of Cognition in Long Term Survivors

Condition:   Primary Central Nervous System Lymphoma (PCNSL)
Intervention:  
Sponsors:   OHSU Knight Cancer Institute;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified April 2015

Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)

Conditions:   Amyotrophic Lateral Sclerosis;   Lou Gehrig's Disease;   Primary Lateral Sclerosis;   Nervous System Diseases;   Hereditary Spastic Paraparesis
Intervention:   Other: No intervention
Sponsors:   Massachusetts General Hospital;   ALS Association;   ALS Therapy Alliance;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified April 2015

Catheter Ablation vs. Standard Conventional Treatment in Patients With LV Dysfunction and AF

Conditions:   Atrial Fibrillation;   Heart Failure
Interventions:   Procedure: Radiofrequency ablation;   Other: Conventional treatment
Sponsor:   Biotronik SE & Co. KG
Recruiting - verified April 2015

Supraphysiologic Insulin to Improve Outcomes After Surgical Treatment of Unruptured Cerebral Aneurysms

Condition:   Intracranial Aneurysm
Intervention:   Drug: Insulin
Sponsor:   Northwestern University
Withdrawn - verified April 2015

ICP Waveform Analysis in Stroke Patients

Condition:   Stroke
Intervention:  
Sponsor:   Oslo University Hospital
Withdrawn - verified October 2010

RESPECT PFO Clinical Trial

Condition:   Cryptogenic Stroke
Interventions:   Device: AMPLATZER PFO Occluder;   Other: Standard of Care - Medical Management
Sponsor:   St. Jude Medical
Active, not recruiting - verified April 2015

Establish The Benefits Of Using Various Starting Doses Of Atorvastatin On Achievement Of Cholesterol Targets (ACTFAST)

Conditions:   Coronary Arteriosclerosis;   Diabetes Mellitus, Type 2;   Cerebrovascular Accident;   Dyslipidemia;   Peripheral Vascular Disease
Intervention:   Drug: Atorvastatin (Lipitor)
Sponsor:   Pfizer
Completed - verified April 2015

PET and Recovery Following Revascularization (PARR 2)

Conditions:   Coronary Artery Disease;   Ventricular Dysfunction, Left
Interventions:   Procedure: Positron emission tomography: FDG viability imaging;   Other: PET imaging
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research  (CIHR);   Heart and Stroke Foundation of Ontario
Completed - verified April 2015

Effects Of Atorvastatin On Macrophage Activity And Plaque Inflammation Using Magnetic Resonance Imaging

Conditions:   Atherosclerotic Carotid Disease;   Atheroma;   Atherosclerosis
Intervention:   Drug: atorvastatin
Sponsor:   GlaxoSmithKline
Completed - verified April 2015

Vision Testing in Patients With Partial Seizures Receiving Either Lyrica or Placebo

Condition:   Epilepsies, Partial
Interventions:   Drug: Lyrica (pregabalin);   Drug: placebo
Sponsor:   Pfizer
Recruiting - verified April 2015

Dexamethasone for Cardiac Surgery Trial

Conditions:   Systemic Inflammatory Response Syndrome;   Cardiac Diseases;   Postoperative Complications
Intervention:   Drug: Dexamethasone
Sponsor:   UMC Utrecht
Completed - verified April 2015

Registry of Unexplained Cardiac Arrest

Conditions:   Cardiac Arrest;   Long QT Syndrome;   Brugada Syndrome;   Catecholaminergi Polymorphic Ventricular Tachycardia;   Idiopathic VentricularFibrillation;   Early Repolarization Syndrome;   Arrhythmogenic Right Ventricular Cardiomyopathy
Intervention:  
Sponsors:   University of British Columbia;   Heart and Stroke Foundation of Ontario;   Boston Scientific Corporation;   Medtronic
Recruiting - verified April 2015

Lipitor In The Prevention Of Stroke, For Patients Who Have Had A Previous Stroke

Condition:   Cardiovascular Disease
Intervention:   Drug: atorvastatin
Sponsor:   Pfizer
Completed - verified April 2015

CONCEPT: Crossover Efficacy Pain Trial in Motor Cortex Stimulation for Intractable Neuropathic Pain

Conditions:   Pain, Intractable;   Facial Pain
Intervention:   Device: Cortical lead, 8 electrodes (Model 2976) with Synergy neurostimulator
Sponsor:   Medtronic
Terminated - verified April 2015

Spinal Cord Stimulation to Restore Cough

Conditions:   Spinal Cord Injuries;   Spinal Cord Diseases;   Paralysis;   Central Nervous System Diseases;   Cough;   Trauma, Nervous System;   Wounds and Injuries
Interventions:   Procedure: Spinal Cord Stimulation;   Device: Expiratory Muscle Stimulator
Sponsors:   Case Western Reserve University;   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified April 2015

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