Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Design and Evaluation the Effects of Kinect-based Computer Games for U/E Training in Chronic Stroke Patients

Condition:   Stroke
Interventions:   Device: Kinect;   Behavioral: Traditional occupational therapy
Sponsor:   Chang Gung Memorial Hospital
Active, not recruiting - verified February 2017

Anesthesia Management in Endovascular Therapy for Ischemic Stroke

Conditions:   Stroke;   Thrombectomy;   Anesthesia;   Conscious Sedation
Interventions:   Procedure: General anaesthesia;   Procedure: Conscious Sedation
Sponsors:   University Hospital, Clermont-Ferrand;   Direction Générale de l'Offre de Soins
Not yet recruiting - verified July 2017

Quelling of Excitotoxicity in Acute Stroke With Ketamine

Condition:   Acute Ischemic Stroke
Interventions:   Drug: Ketamine;   Other: Normal Saline;   Drug: Midazolam injection
Sponsor:   Doylestown Health
Not yet recruiting - verified July 2017

Adipose Tissue Content of Fatty Acids Present in Dairy Fat and Risk of Stroke. The Danish Diet, Cancer and Health Cohort

Condition:   Stroke
Intervention:   Other: Fatty acids present in adipose tissue samples
Sponsor:   University of Aarhus
Completed - verified July 2017

Cohort Study for Severe Ischaemic Stroke

Conditions:   Severe Ischaemic Stroke;   Malignant Ischaemic Stroke
Intervention:   Other: routine medical care
Sponsors:   West China Hospital;   Sichuan Academy of Medical Sciences &Sichuan Provincial People’s Hospital;   The Affiliated Hospital Of Southwest Medical University;   Affiliated Hospital of North Sichuan Medical College;   Chengdu University of Traditional Chinese Medicine;   Mianyang Central Hospital;   People’s Hospital of Deyang City;   The First People’s Hospital of Ziyang;   Jiangyou People’s Hospital;   Science & Technology Department of Sichuan Province;   National Natural Science Foundation of China
Not yet recruiting - verified July 2017

A Trial Investigating Telerehabilitation as an add-on to Face-to-face Speech and Language Therapy in Post-stroke Aphasia.

Conditions:   Aphasia;   Chronic Stroke;   Post Stroke Seizure
Interventions:   Behavioral: ucSLT;   Device: teleSLT;   Device: teleCT
Sponsor:   University of Bern
Not yet recruiting - verified July 2017

The Effectiveness of Oral Health in Improving Dysphagia of Patients After Stroke of Swallowing Function and Oral Health Quality of Life

Conditions:   Swallowing Disorders;   Stroke
Intervention:   Other: oral care program
Sponsor:   Chang Gung Memorial Hospital
Recruiting - verified July 2017

Validation of Cardiometry in Resuscitation of Patients Undergoing Liver Transplantation

Condition:   Liver Transplantation
Intervention:   Other: fluid boluses
Sponsor:   Kasr El Aini Hospital
Recruiting - verified July 2017

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Conditions:   Frontotemporal Lobar Degeneration;   Amytrophic Lateral Sclerosis;   Progressive Supranuclear Palsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 14, 2017

Pathophysiology of Dystonia and Complex Regional Pain Syndrome

Conditions:   Dystonia;   Complex Regional Pain Syndromes
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified July 7, 2017

Measuring the Latency Connectome in the Central Nervous Systems Using Neuroimaging and Neurophysiological Techniques

Condition:   Healthy Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified July 10, 2017

Stroke Volume Variation vs Central Venous Pressure Guidance Fluid Management in Endovascular Aortic Repair

Condition:   Postoperative Complications
Intervention:   Procedure: Fluid management protocol
Sponsor:   Khon Kaen University
Recruiting - verified July 2017

Red Meat, Increased Iron Load and CVD Risk

Conditions:   Myocardial Infarction;   Stroke;   Cardiovascular Mortality
Intervention:   Other: No intervention assigned, this is an observational study.
Sponsor:   German Cancer Research Center
Completed - verified July 2017

The PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - PARTNER II - High Risk and Nested Registry 7

Condition:   Symptomatic Severe Aortic Stenosis
Intervention:   Device: TAVR Implantation of the THV Prosthesis
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified July 2017

Thrombolysis and RIPC in Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke, Cerebral Embolism and Thrombosis
Intervention:   Device: RIPC device (IPC-906X)
Sponsor:   First Affiliated Hospital Xi'an Jiaotong University
Not yet recruiting - verified July 2017

The PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - PARTNER II - PARTNERII - S3 Intermediate

Condition:   Symptomatic Severe Aortic Stenosis
Intervention:   Device: TAVR
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified July 2017

Ginkgo Diterpene Lactone Meglumine Injection on Platelet Reactivity in Acute Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: Ginkgo Diterpene Lactone Meglumine Injection;   Drug: Acetylsalicylic acid
Sponsors:   RenJi Hospital;   Jiangsu Kanion Pharmaceutical Co., Ltd
Not yet recruiting - verified May 2017

RNA Sequencing in the Framingham Heart Study Third Generation Cohort Exam 2

Conditions:   Cardiovascular Disease;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation - verified July 14, 2017

Choline Alphoscerate-Nimodipine in Vascular Cognitive Impairment

Condition:   Vascular Cognitive Impairment
Interventions:   Drug: Choline alphoscerate;   Drug: Placebo
Sponsors:   Azienda Ospedaliero-Universitaria Careggi;   MDM S.p.A.
Recruiting - verified July 2017

Stent Retriever's(TonbridgeMT) Endovascular Therapy for Acute Ischemic Stroke(AIS)

Condition:   Ischemic Stroke
Interventions:   Device: stent retriever(TonbridgeMT);   Device: Solitaire™
Sponsors:   Zhuhai Tonbridge Medical Tech. Co., Ltd.;   Guangzhou Osmunda Medical Device Technology, Inc., Ltd.
Not yet recruiting - verified June 2017

Brain Plasticity Mapping Post-stroke

Condition:   Stroke
Intervention:   Other: Motor rehabilitation training
Sponsor:   University Hospital, Montpellier
Not yet recruiting - verified June 2017

A Novel Strategy For Personalized Long-Term Dual Antiplatelet Therapy (RAPID EXTEND)

Conditions:   Stable Coronary Syndrome;   Percutaneous Coronary Intervention;   Antiplatelet Therapy;   Ticagrelor
Interventions:   Drug: Ticagrelor 60mg;   Drug: Clopidogrel 75mg;   Drug: Aspirin 81 mg
Sponsor:   Ottawa Heart Institute Research Corporation
Not yet recruiting - verified July 2017

Influence of Circulating Endothelial Progenitor Cells and Modifiable Vascular Risk Factors on Carotid Plaque Vulnerability

Conditions:   Atherosclerosis;   Stroke;   Inflammation
Intervention:  
Sponsors:   Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau;   Instituto de Salud Carlos III
Recruiting - verified July 2017

Prospective Urban Rural Epidemiology Study

Conditions:   Cardiovascular Diseases;   Risk Factor, Cardiovascular;   Health Behavior;   Environmental Exposure;   Lung Diseases;   Cancer;   Injuries;   Renal Disease;   Communicable Disease
Intervention:  
Sponsors:   Population Health Research Institute;   Canadian Institutes of Health Research (CIHR);   Heart and Stroke Foundation of Ontario
Recruiting - verified July 2017

Simulation-based Training of Rapid Evaluation and Management for Acute Stroke (STREAM) Trial

Condition:   Stroke, Thrombolysis, Thrombectomy, Simulation Training, Patient Safety
Intervention:   Other: Stroke team simulation training
Sponsors:   Johann Wolfgang Goethe University Hospital;   Stryker Neurovascular
Not yet recruiting - verified July 2017

Feasibility and Safety of Delivering a Ketone Drink to Comatose Survivors of Out-of-hospital Cardiac Arrest

Condition:   Out-Of-Hospital Cardiac Arrest
Intervention:   Dietary Supplement: Ketone ester drink
Sponsors:   Barts & The London NHS Trust;   University College, London
Not yet recruiting - verified July 2017

Randomization of Single vs Multiple Arterial Grafts

Conditions:   Coronary Artery Disease;   Heart Diseases
Interventions:   Procedure: Single arterial graft;   Procedure: Multiple arterial grafting
Sponsors:   Weill Medical College of Cornell University;   Sunnybrook Health Sciences Centre;   Duke University;   The Cleveland Clinic;   Heartcenter Leipzig GmbH;   University of Rotterdam, The Netherlands;   Maastricht University Medical Center;   University College Hospital Galway;   Ottawa Heart Institute Research Corporation;   University of Toledo Health Science Campus
Not yet recruiting - verified July 2017

Combination of Static Echocardiographic Indices for Prediction of Fluid Responsiveness During Cardiac Surgery

Condition:   Fluid Responsiveness
Intervention:  
Sponsor:   Yonsei University
Not yet recruiting - verified July 2017

A Phase 4 Safety and Efficacy Study to Evaluate Lesinurad 200 mg in Participants With Gout and Renal Impairment

Conditions:   Gout;   Chronic Kidney Disease (CKD)
Interventions:   Drug: Lesinurad;   Drug: XOI;   Drug: Placebo
Sponsors:   Ironwood Pharmaceuticals, Inc.;   Medpace, Inc.
Recruiting - verified July 2017

Guided Training for People With Cognitive Impairment

Conditions:   TBI (Traumatic Brain Injury);   Stroke;   Cognitive Impairment
Intervention:   Behavioral: Guided Training
Sponsor:   Taipei Medical University WanFang Hospital
Not yet recruiting - verified July 2017

Loss of Depotentiation in Focal Dystonia

Conditions:   Focal Dystonia;   Healthy Volunteers
Intervention:   Other: PAS25-cTBS150
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified June 28, 2017

Walk Assist Device to Improve Community Ambulation

Condition:   Stroke
Interventions:   Device: Honda Stride Assist Device ON;   Other: No Device Worn
Sponsor:   Shirley Ryan AbilityLab
Completed - verified July 2017

Noninvasive Brain Stimulation Training

Condition:   Brain Injuries
Interventions:   Device: non invasive brain stimulation;   Device: sham stimulation
Sponsor:   Neuromed IRCCS
Not yet recruiting - verified July 2017

Atrial Fibrillation Occurring Transiently With Stress (AFOTS)

Condition:   Atrial Fibrillation New Onset
Intervention:   Diagnostic Test: 14 Day ECG Patch (Zio XT Patch, iRhythm Technologies)
Sponsors:   Population Health Research Institute;   Canadian Cardiovascular Society;   Canadian Stroke Prevention Intervention Network
Recruiting - verified July 2017

POTS NET mRNA Functional Correlation With NET Activity

Condition:   Postural Tachycardia Syndrome
Interventions:   Diagnostic Test: NET mRNA level;   Diagnostic Test: Plasma catechols;   Diagnostic Test: Urine Catechols
Sponsors:   Vanderbilt University Medical Center;   National Institute of Neurological Disorders and Stroke (NINDS);   University of Calgary;   Dysautonomia International
Enrolling by invitation - verified July 2017

D-aspartate and Therapeutic Exercise

Condition:   Brain Injuries
Interventions:   Drug: D-Aspartate;   Behavioral: Therapeutic exercise;   Drug: Placebo Oral Tablet
Sponsor:   Neuromed IRCCS
Not yet recruiting - verified July 2017

Non-invasive Absolute Intracranial Pressure Measurement in Patients With Malignant Middle Cerebral Artery Infarction for Determination of Timing to Descompressive Craniectomy.

Condition:   Intracranial Pressure Increase
Intervention:   Device: Medical Device Vittamed 205
Sponsors:   Kienzler Jenny;   Schweizer National Fond
Not yet recruiting - verified July 2017

XIENCE Short Dual Antiplatelet Therapy (DAPT) Study

Condition:   Coronary Artery Lesions
Interventions:   Device: XIENCE;   Drug: DAPT
Sponsor:   Abbott Vascular
Not yet recruiting - verified July 2017

Effect of an Analgo-sedation Protocol for Patients With Spontaneous Intracerebral Hemorrhage

Conditions:   CVA (Cerebrovascular Accident);   Cerebral Hemorrhage;   Intracranial Hemorrhages
Interventions:   Behavioral: Analgosedation;   Behavioral: Procedural pain relief
Sponsor:   Hong Yang
Not yet recruiting - verified July 2017

Stimulation for Perinatal Stroke Optimizing Recovery Trajectories

Conditions:   Perinatal Stroke;   Hemiplegic Cerebral Palsy
Interventions:   Device: Cathodal transcranial direct current stimulation;   Device: Sham transcranial direct current stimulation
Sponsors:   University of Calgary;   University of Alberta;   Holland Bloorview Kids Rehabilitation Hospital;   The Hospital for Sick Children
Recruiting - verified July 2017

Tenecteplase in Wake-up Ischaemic Stroke Trial

Conditions:   Ischemic Stroke;   Stroke, Acute
Interventions:   Drug: Tenecteplase;   Other: Control
Sponsors:   University Hospital of North Norway;   UiT The Arctic University of Norway;   The Royal Norwegian Ministry of Health;   Norwegian Health Association
Recruiting - verified April 2017

Brilinta Clinical Experience Investigation

Condition:   Acute Coronary Syndrome, Old Myocardial Infarction
Intervention:  
Sponsor:   AstraZeneca
Not yet recruiting - verified July 2017

Diabetes Intervention Accentuating Diet and Enhancing Metabolism

Condition:   Diabetes Mellitus, Type 2
Intervention:   Dietary Supplement: Low Energy Diet
Sponsors:   Weill Cornell Medical College in Qatar;   Hamad Medical Corporation;   Weill Medical College of Cornell University;   Cornell University
Recruiting - verified July 2017

Effects of Inspiratory Muscle Training on the Functional Gait Performance of Individuals After Stroke

Conditions:   Stroke;   Inspiratory Muscle Training;   Quality of Life;   Gait
Intervention:   Other: Inspiratory Muscle Training
Sponsor:   Lorena de Oliveira Vaz Miranda
Recruiting - verified July 2017

Effectiveness of a Massage Protocol Versus Muscle Chain for Hamstring

Condition:   Hamstring Contractures
Interventions:   Other: Massage;   Other: Muscle chains;   Other: Placebo treatment
Sponsor:   University of Valencia
Recruiting - verified July 2017

Does Early Administration of Tranexamic Acid Reduce Blood Loss and Perioperative Transfusion Requirement

Condition:   Hip Fractures
Interventions:   Drug: Tranexamic Acid (TXA);   Drug: Placebo
Sponsor:   Mayo Clinic
Recruiting - verified July 2017

HOW To Optimally Implant BioResorbable Scaffold - Intravascular Imaging Versus Quantitative Coronary Angiography Guidance

Condition:   Coronary Stenosis
Interventions:   Device: quantitative coronary angiography guided Bioresorbable scaffold implantation;   Device: imaging guided Bioresorbable scaffold implantation
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea
Not yet recruiting - verified July 2017

Determinants of Balance Recovery After Stroke - Retrospective Study

Condition:   Stroke
Intervention:   Behavioral: Postural Assessment Scale for Stroke (PASS)
Sponsor:   University Hospital, Grenoble
Completed - verified July 2017

Volumetric Integral Phase-shift Spectroscopy for Noninvasive Detection of Hemispheric Bioimpedance Asymmetry in Acute Brain Pathology

Conditions:   Stroke;   Stroke, Acute;   Ischemic Stroke;   Hemorrhage;   Clot (Blood); Brain;   Subarachnoid Hemorrhage;   Cerebral Infarction;   Cerebral Hemorrhage;   Cerebral Stroke;   Intracerebral Hemorrhage;   Intracerebral Injury
Intervention:   Diagnostic Test: VIPS Monitoring
Sponsor:   Cerebrotech Medical Systems, Inc.
Active, not recruiting - verified July 2017

Pivotal Study of VNS During Rehab After Stroke (VNS-REHAB)

Conditions:   Cerebrovascular Stroke;   Upper Extremity Paresis
Interventions:   Device: Paired Vagus Nerve Stimulation;   Other: Rehabilitation
Sponsors:   MicroTransponder Inc.;   ResearchPoint Global
Recruiting - verified July 2017

Study of the Combination of Low-Intensity Chemotherapy and Ponatinib in Patients With Philadelphia Chromosome (Ph)-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia (ALL)

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Ponatinib;   Drug: Cyclophosphamide;   Drug: Mesna;   Drug: Rituximab;   Drug: Vincristine;   Drug: Dexamethasone;   Drug: G-CSF;   Drug: Methotrexate (intrathecally);   Drug: Cytarabine (intrathecally);   Drug: Methotrexate;   Drug: Cytarabine
Sponsors:   M.D. Anderson Cancer Center;   Ariad Pharmaceuticals
Not yet recruiting - verified July 2017

Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

Condition:   Multiple Sclerosis
Interventions:   Drug: Pioglitazone;   Drug: Montelukast;   Drug: Losartan;   Drug: Hydroxychloroquine
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 6, 2017

Feasibility and Acceptability of Orthotic Shorts for People With Multiple Sclerosis

Condition:   Multiple Sclerosis
Interventions:   Device: Orthotic shorts;   Device: Placebo shorts
Sponsors:   Sheffield Hallam University;   Sheffield Teaching Hospitals NHS Foundation Trust
Not yet recruiting - verified July 2017

Does N-Acetylcysteine Decrease Spontaneous Oxidation of Central Neural Dopamine in Parkinson's Disease?

Condition:   Parkinson Disease
Interventions:   Dietary Supplement: N-Acetylcysteine;   Procedure: Lumbar Puncture;   Radiation: Fluoroscopy
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 10, 2017

Transforming Robot-mediated Telerehabilitation: Citizen Science for Rehabilitation

Conditions:   Hemiparesis;   Stroke
Interventions:   Behavioral: Output-Focus Condition;   Behavioral: Input-Focus Condition
Sponsor:   New York University School of Medicine
Not yet recruiting - verified July 2017

A Prospective Cohort Study of Perioperative Covert Stroke and Postoperative Cognitive Dysfunction

Conditions:   Anesthesia;   Postoperative Cognitive Dysfunction;   Covert Stroke
Intervention:  
Sponsor:   Beijing Tiantan Hospital
Recruiting - verified July 2017

Multicenter Cohort of STEMI Patients

Condition:   STEMI - ST Elevation Myocardial Infarction
Interventions:   Biological: Blood sampling;   Procedure: ECG;   Device: MRI;   Other: Quality of life questionnaire
Sponsor:   Hospices Civils de Lyon
Recruiting - verified February 2017

Secondary Prevention By Structured Semi-Interactive Stroke Prevention Package in INDIA (SPRINT INDIA) Study

Condition:   Stroke
Intervention:   Other: Structured Semi-Interactive Stroke Prevention Package
Sponsors:   Christian Medical College and Hospital, Ludhiana, India;   Indian Council of Medical Research
Not yet recruiting - verified July 2017

Pulmonary CT in Pneumonia Complicating Stroke

Conditions:   Stroke;   Pneumonia
Intervention:   Radiation: pulmonary computed tomography (CT)
Sponsor:   Natalie Garratt
Recruiting - verified July 2017

Functional Connectivity as a Biomarker of rTMS

Condition:   Traumatic Brain Injury
Intervention:   Device: rTMS
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 21, 2017

Evaluation of Transcatheter Aortic Valve Replacement Compared to SurveilLance for Patients With AsYmptomatic Severe Aortic Stenosis

Conditions:   Aortic Stenosis;   Heart Diseases
Intervention:   Device: Edwards SAPIEN 3 THV
Sponsor:   Edwards Lifesciences
Not yet recruiting - verified July 2017

Neurophysiologic Study of Patient With Essential Tremor and Dystonic Tremor

Conditions:   Essential Tremor;   Cervical Dystonia;   Focal Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 5, 2017

Prognostic Value of Plasma DPP4 Activity in ST-elevation Myocardial Infarction Patients

Conditions:   Coronary Angiography;   Dipeptidyl Peptidase 4
Intervention:   Diagnostic Test: plasma DPP4 activity
Sponsor:   Chinese PLA General Hospital
Completed - verified July 2017

Molecular Investigation of Genetic Factors in CArDiovascular Diseases Using an BIOresource of Healthy Volunteers

Condition:   Cardiovascular Diseases
Interventions:   Other: Eligibility and lifestyle restrictions check.;   Other: Medical history, demographic and lifestyle factors;   Other: Anthropometric measurements: height, weight, and body fat;   Other: Blood pressure and heart rate;   Other: Forearm blood flow: Visit 1 (EDNRA);   Other: Forearm blood flow: Visit 2 (EDNRA);   Other: Blood biochemistry (PNPLA3);   Other: Blood EPCR function (PROCR);   Other: Blood platelet coagulation and function (PROCR);   Other: Blood endothelial permeability (PROCR);   Other: Blood leukocyte-endothelium adhesion (PROCR);   Other: Baseline Venepuncture (PNPLA3, Visit 1);   Other: Deuterium water - Loading dose 1 (PNPLA3, Visit 1);   Other: Deuterium water - Loading dose 2 (PNPLA3, Visit 1);   Other: Energy-balanced dinner (PNPLA3, Visit 1);   Other: Fasting venepuncture (PNPLA3, Visit 2);   Other: Deuterium water - Maintenance dose (PNPLA3, Visit 2);   Other: Consumption of high carbohydrate meal (PNPLA3, Visit 2);   Other: Postprandial Venepuncture (PNPLA3, Visit 2);   Other: Venepuncture (PROCR)
Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   University of Cambridge
Not yet recruiting - verified July 2017

Ross Operation Failure Database

Conditions:   Ross Operation;   Pulmonary Autograft;   Structural Valve Degeneration
Intervention:   Procedure: Ross Operation
Sponsors:   Centre Cardiologique du Nord;   Golden Jubilee National Hospital;   University of Bern;   Pontifícia Universidade Católica do Paraná;   Ospedale San Donato;   Groupe Hospitalier Pitie-Salpetriere;   Royal Children's Hospital
Enrolling by invitation - verified July 2017

Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Prolonged DAPT Regimen

Conditions:   High Bleeding Risk;   Coronary Artery Disease;   PCI
Interventions:   Drug: Aspirin;   Drug: P2Y12 inhibitor
Sponsors:   ECRI bv;   Cardialysis B.V.;   European Cardiovascular Research Center;   University of Bern;   Terumo Medical Corporation
Recruiting - verified July 2017

Prevention of Ischemic Conditions in Non-disabling Stroke/Transient Ischemic Attack With Remote Ischemic Conditioning

Conditions:   Transient Ischemic Attack;   Non-disabling Stroke
Intervention:   Device: Remote Ischemic Conditioning
Sponsor:   Capital Medical University
Recruiting - verified July 2017

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

Condition:   Mitral Valve Failure
Interventions:   Device: Edwards SAPIEN 3 transcatheter heart valve;   Device: ASHI INTECC Astato XS 20
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified May 11, 2017

The PARTNER 3 - AVIV Trial

Conditions:   Aortic Stenosis;   Cardiomyopathy, Hypertrophic
Intervention:   Device: Edwards SAPIEN 3 transcatheter valve, Model 9600TFX
Sponsor:   Edwards Lifesciences
Recruiting - verified July 2017

Opportunistic Screening in Pharmacies for Atrial Fibrillation in Seniors (>65 Years)

Condition:   Incidence of Atrial Fibrillation in Adults Aged ≥ 65
Intervention:  
Sponsors:   RWTH Aachen University;   Apothekerverband Aachen e.V.;   Pfizer
Active, not recruiting - verified July 2017

RAD001 and Neurocognition in PTEN Hamartoma Tumor Syndrome (PTEN)

Conditions:   PTEN Gene Mutation;   PTEN Hamartoma Tumor Syndrome
Interventions:   Drug: RAD001;   Drug: Placebo
Sponsors:   Boston Children’s Hospital;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   Office of Rare Diseases (ORD);   National Center for Advancing Translational Science (NCATS);   Novartis Pharmaceuticals;   PTEN Research Foundation
Recruiting - verified July 2017

Computerized Acoustic Swallowing Evaluation

Conditions:   Deglutition Disorders;   Stroke
Intervention:   Other: Swallowing Screen
Sponsor:   Cedars-Sinai Medical Center
Withdrawn - verified July 2017

Effects of Prism Adaption and rTMS on Brain Connectivity and Visual Representation

Conditions:   Normal Physiology;   Stroke
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 12, 2016

BioVentrix Revivent TC™ System Clinical Study

Condition:   Ventricular Dysfunction, Left
Intervention:   Device: Revivent TC
Sponsor:   BioVentrix
Recruiting - verified July 2017

Description and Modeling of Swallowing Disorders After a Stroke

Conditions:   Stroke;   Swallowing Disorders
Interventions:   Other: Neurological evaluation;   Other: Laryngological evaluation;   Other: MRI evaluation;   Other: Breathing investigation;   Other: MRI and articulatory investigation;   Other: Postural investigation;   Other: Voice and soundscape investigation
Sponsors:   University Hospital, Grenoble;   National Research Agency, France;   University Hospital, Caen;   University Hospital, Montpellier;   Centre Hospitalier du Pays d'Aix;   Université Joseph Fourier
Recruiting - verified August 2016

Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND)

Condition:   Anaemia
Interventions:   Drug: Daprodustat;   Drug: Darbepoetin alfa;   Drug: Placebo;   Drug: Iron Therapy
Sponsor:   GlaxoSmithKline
Recruiting - verified July 2017

Benefit-Risk Of Arterial THrombotic prEvention With Rivaroxaban for Atrial Fibrillation in France

Condition:   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Vitamin K antagonists;   Drug: dabigatran (Pradaxa)
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting - verified July 2017

Effect of Music on Reading Comprehension for Patients With Aphasia

Condition:   Aphasia
Interventions:   Behavioral: Simultaneous music and reading lyrics;   Behavioral: Priming with music;   Behavioral: Control
Sponsor:   Carilion Clinic
Enrolling by invitation - verified July 2017

China PEACE 5p-HF Study

Condition:   Heart Failure
Intervention:   Other: Observational study
Sponsor:   China National Center for Cardiovascular Diseases
Not yet recruiting - verified July 2017

The Effect of Intraoperative Goal Directed Restricted Fluid Therapy on Extravascular Lung Water

Condition:   Surgery
Interventions:   Procedure: Restricted fluid therapy group;   Procedure: Standard fluid management
Sponsor:   Cairo University
Completed - verified July 2017

A Reduction in Time With Electronic Monitoring In Stroke

Conditions:   Acute Ischemic Stroke;   Stroke
Intervention:   Other: real-time audio-visual feedback
Sponsors:   Leiden University Medical Center;   The Dutch Brain Foundation;   Innovation Fund Healthcare Insurers, the Netherlands
Not yet recruiting - verified July 2017

Interaction Research on Cognitive Impairment and Emotional Disorder in End-stage Renal Disease

Conditions:   End-stage Kidney Disease;   Brain Damage
Intervention:  
Sponsors:   First Affiliated Hospital Xi'an Jiaotong University;   Xidian University
Recruiting - verified July 2017

Treatment Convenience in Patients Treated With Dabigatran for Stroke Prophylaxis in Atrial Fibrillation (SPAF)

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified July 2017

Clinical, Biochemical and Haemodynamic Effects of Large-volume Paracentesis (LVP) in Inflammatory Situations

Condition:   Paracentesis
Intervention:  
Sponsors:   Charite University, Berlin, Germany;   Technische Universität Berlin;   Humboldt-Universität zu Berlin
Recruiting - verified July 2017

Precutaneous High Risk Patent Foramen Ovale to Treat Migraine Headaches

Condition:   Patent Foramen Ovale
Intervention:   Procedure: the transcatheter closure of PFO
Sponsors:   First Affiliated Hospital Xi'an Jiaotong University;   Second Affiliated Hospital of Xi'an Jiaotong University;   Fourth Military Medical University;   Southwest Hospital, China
Recruiting - verified July 2017

Telemedicine Monitoring of Sleep Apnea in Stroke

Conditions:   Stroke;   Sleep Apnea
Intervention:   Device: Auto CPAP AirSense™ 10(Resmed)
Sponsor:   Neurologisches Rehabiliationszentrum Rosenhügel
Active, not recruiting - verified July 2017

Stroke Prevention and Treatment System in Shanghai: a Network of Public Healthcare of Stroke

Condition:   Stroke
Intervention:   Other: stroke network and policy intervention
Sponsors:   Shanghai Stroke Service System;   Huashan Hospital;   Shanghai Zhongshan Hospital;   Ruijin Hospital;   theTenth People's Hospital;   the Sixth People's Hospital;   RenJi Hospital;   ShuGuang Hospital;   Dongfang Hospital Affiliated to Beijing University of Chinese Medicine;   Changzheng Hospital;   Changhai Hospital;   the Ninth People's Hospital
Recruiting - verified July 2017

Fluoxetine for Visual Recovery After Ischemic Stroke

Conditions:   Acute Stroke;   Visual Field Loss
Interventions:   Drug: Fluoxetine;   Drug: Placebo
Sponsor:   Bogachan Sahin
Recruiting - verified July 2017

Transplantation Using Reduced Intensity Approach for Patients With Sickle Cell Disease From Mismatched Family Donors of Bone Marrow

Condition:   Sickle Cell Disease
Interventions:   Procedure: Bone Marrow Transplant (BMT);   Procedure: Bone Marrow Harvest (Donation);   Drug: Hydroxyurea;   Drug: Thiotepa;   Drug: Fludarabine monophosphate;   Drug: Cyclophosphamide;   Other: Rabbit Anti-thymocyte Globulin;   Radiation: Total Body Irradiation
Sponsor:   Emory University
Recruiting - verified July 2017

Evaluation of a Wearable Exoskeleton for Functional Arm Training

Conditions:   Stroke;   Post-Stroke Hemiparesis
Interventions:   Other: Gravity Elimination Alone;   Other: Path Assistance Alone;   Other: Path Assistance and Gravity Elimination
Sponsor:   New York University School of Medicine
Active, not recruiting - verified July 2017

An fMRI Study of Jianpi Yishen Huatan Granules for Cognitive Impairment After Acute Cerebral Infarction

Condition:   Cognitive Impairment
Interventions:   Drug: Jianpi Yishen Huatan Granules;   Other: the placebo
Sponsor:   Dongfang Hospital Affiliated to Beijing University of Chinese Medicine
Recruiting - verified July 2017

SunRISe Study - Stroke Rehabilitation In Suriname

Condition:   Stroke
Intervention:   Behavioral: Home base stroke rehabilitation
Sponsors:   Katholieke Universiteit Leuven;   Anton De Kom University;   VU University of Amsterdam
Completed - verified July 2017

A Novel Strategy to Decrease Fall Incidence Post-Stroke

Condition:   Stroke
Intervention:   Behavioral: Backward Walking Training
Sponsor:   VA Office of Research and Development
Recruiting - verified July 2017

Intranasal Insulin and Post-stroke Cognition: A Pilot Study

Condition:   Stroke
Interventions:   Drug: Intranasal Insulin;   Drug: Intranasal saline
Sponsor:   Wake Forest University Health Sciences
Recruiting - verified July 2017

Myalgic Encephalomyelitis Chronic Fatigue at the National Institutes of Health

Condition:   Chronic Fatigue Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 29, 2017

Biofeedback to Increase Propulsion During Walking After Stroke

Condition:   Stroke
Interventions:   Procedure: Gait Training with Biofeedback;   Procedure: Gait Training with Verbal Feedback
Sponsor:   VA Office of Research and Development
Recruiting - verified July 2017

The PARTNER 3 - Trial - The Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis

Condition:   Aortic Stenosis
Interventions:   Procedure: Surgical aortic valve replacement (SAVR);   Device: Transcatheter Aortic Valve Replacement (TAVR)
Sponsor:   Edwards Lifesciences
Recruiting - verified July 2017

Consolidating Tools for Outcomes in Resuscitation

Conditions:   Cardiac Arrest;   Cardiopulmonary Resuscitation;   Simulation;   Education
Interventions:   Device: Knowledge-based cognitive aid;   Device: Cognitive aids with roles defined (CARD);   Device: Integrated cognitive aids
Sponsors:   Ottawa Hospital Research Institute;   The Physicians' Services Incorporated Foundation;   University of Ottawa;   Children's Hospital of Eastern Ontario;   The Hospital for Sick Children;   Montreal Children's Hospital of the MUHC;   Alberta Children's Hospital;   Stollery Children's Hospital
Not yet recruiting - verified July 2017

The Effects of tDCS Combined With Balance Training on Lower Limbs Spasticity in Chronic Stroke Patients

Condition:   Ischemic Stroke
Interventions:   Device: Transcranial direct current stimulation (tDCS);   Device: Sham tDCS
Sponsor:   Shahid Beheshti University of Medical Sciences
Recruiting - verified July 2017

Diversion-p64 Post Market Clinical Follow-Up Study to Assess Safety and Effectiveness of the p64 Flow Modulation Device

Condition:   Intracranial Aneurysm
Intervention:  
Sponsor:   Phenox GmbH
Recruiting - verified July 2017

Driving Neuroplasticity With Nerve Stimulation and Modified CIT

Conditions:   Stroke;   Cerebrovascular Accident
Intervention:   Device: peripheral nerve stimulation
Sponsor:   University of Kentucky
Completed - verified July 2017

Hyperbaric Oxygen Post Established Stroke

Conditions:   Stroke;   Ischemic Stroke;   Established Stroke
Interventions:   Other: Hyperbaric Oxygen;   Other: Sham Hyperbaric Oxygen
Sponsor:   University of British Columbia
Recruiting - verified July 2017

Beauty From Within Community Screening Project

Condition:   Heart Health Screening and Prevention
Interventions:   Procedure: Fingerstick cholesterol test;   Other: Atherosclerosis Cardiovascular Disease Risk assessment;   Procedure: Blood pressure measurement
Sponsor:   Cedars-Sinai Medical Center
Active, not recruiting - verified July 2017

Special Drug Use Investigation of Xarelto for Venous Thromboembolism (VTE)

Condition:   Venous Thromboembolism
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting - verified July 2017

Global Study Comparing a rivAroxaban-based Antithrombotic Strategy to an antipLatelet-based Strategy After Transcatheter aortIc vaLve rEplacement to Optimize Clinical Outcomes

Condition:   Transcatheter Aortic Valve Replacement
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Acetylsalicylic acid;   Drug: Clopidogrel
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting - verified July 2017

pCONus Treatment of Wide Neck Intracranial Aneurysms

Condition:   Intracranial Aneurysm
Intervention:   Device: implantation of the pCONus Bifurcation Aneurysm Implant
Sponsor:   Phenox GmbH
Recruiting - verified July 2017

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified July 2017

Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection

Conditions:   HIV Infections;   Neurologic Disorders
Intervention:   Drug: Anakinra
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Johns Hopkins University
Enrolling by invitation - verified March 16, 2017

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified July 2017

aMAZE Study: LAA Ligation Adjunctive to PVI for Persistent or Longstanding Persistent Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Device: LARIAT + PVI;   Device: Pulmonary Vein Isolation
Sponsor:   SentreHEART, Inc.
Recruiting - verified July 2017

Effect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus
Interventions:   Biological: Albiglutide 30 mg;   Biological: Albiglutide 50 mg;   Biological: Albiglutide matching placebo
Sponsors:   GlaxoSmithKline;   Duke Clinical Research Institute
Active, not recruiting - verified July 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting - verified July 2017

Prompt Diagnosis and Treatment of Subclinical Seizures After Cardiac Arrest

Conditions:   Heart Arrest;   Seizures
Intervention:   Procedure: DSA EEG
Sponsors:   Children's Hospital of Philadelphia;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 2017

Natural History Study of Individuals With Autism and Germline Heterozygous PTEN Mutations

Conditions:   PTEN;   ASD;   Autism;   Macrocephaly;   PTEN Hamartoma Tumor Syndrome
Intervention:  
Sponsors:   Boston Children’s Hospital;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   Office of Rare Diseases (ORD);   National Center for Advancing Translational Science (NCATS)
Recruiting - verified July 2017

Mapping the Genotype, Phenotype, and Natural History of Phelan-McDermid Syndrome

Conditions:   Phelan-McDermid Syndrome;   Autism Spectrum Disorder;   Intellectual Disability
Intervention:  
Sponsors:   Boston Children’s Hospital;   National Institute of Neurological Disorders and Stroke (NINDS);   National Institutes of Health (NIH);   Office of Rare Diseases (ORD);   National Center for Advancing Translational Science (NCATS);   Phelan-McDermid Syndrome Foundation
Recruiting - verified July 2017

Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex (TSC)

Conditions:   Tuberous Sclerosis;   Autism Disorder;   Intellectual Disability
Intervention:  
Sponsors:   Boston Children’s Hospital;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   Tuberous Sclerosis Alliance;   National Center for Advancing Translational Science (NCATS);   Office of Rare Diseases (ORD)
Recruiting - verified July 2017

COcoa Supplement and Multivitamin Outcomes Study

Conditions:   Cardiovascular Disease;   Cancer
Interventions:   Dietary Supplement: Cocoa extract;   Dietary Supplement: Multivitamin;   Dietary Supplement: Cocoa extract placebo;   Dietary Supplement: Multivitamin placebo
Sponsors:   Brigham and Women's Hospital;   Fred Hutchinson Cancer Research Center;   Mars, Inc.;   Pfizer
Recruiting - verified July 2017

Post-Market Clinical Follow-Up Study to Confirm Clinical Performance and Safety of the Codman Enterprise® 2 Vascular Reconstruction Device in the Endovascular Treatment of Intracranial Aneurysms

Condition:   Intracranial Aneurysm
Intervention:   Device: Enterprise 2 Vascular Reconstruction Device
Sponsor:   Codman & Shurtleff
Recruiting - verified July 2017

A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart

Condition:   Acute Coronary Syndromes
Interventions:   Drug: Apixaban;   Drug: vitamin K antagonist;   Drug: Acetylsalicylic acid;   Other: Acetylsalicylic acid placebo
Sponsors:   Bristol-Myers Squibb;   Pfizer;   Duke Clinical Research Institute
Recruiting - verified July 2017

Botulinum Toxin A Associated Costs in the Treatment of Upper Limb Spasticity Post Stroke

Condition:   Upper Limb Spasticity Post-Stroke
Intervention:  
Sponsor:   Ipsen
Active, not recruiting - verified July 2017

Study on the Use of Botulinum Toxin Type A in the Treatment of Chronic Post-stroke Spastic Patients

Condition:   Spasticity
Intervention:  
Sponsor:   Ipsen
Active, not recruiting - verified July 2017

Renal Denervation Using the Vessix Renal Denervation System for the Treatment of Hypertension (REDUCE HTN:REINFORCE)

Condition:   Hypertension
Interventions:   Device: Renal Denervation (Vessix);   Device: Renal Angiography
Sponsor:   Boston Scientific Corporation
Recruiting - verified July 2017

Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism (RESCUE)-Japan Registry 2

Condition:   Ischemic Stroke
Intervention:   Procedure: endovascular treatment
Sponsor:   Hyogo College of Medicine
Completed - verified July 2017

Novel Treatment of Intermittent Claudication in Patients With Peripheral Arterial Disease Using Danshen Gegen (D&G) Capsule

Conditions:   Peripheral Arterial Disease;   Intermittent Claudication
Interventions:   Drug: Danshen Gegen Capsule;   Drug: Placebo
Sponsor:   Chinese University of Hong Kong
Recruiting - verified July 2017

Shockwave Coronary Lithoplasty Study

Condition:   Coronary Stenosis
Intervention:   Device: Shockwave Coronary Lithoplasty System
Sponsors:   Shockwave Medical, Inc.;   Yale Cardiovascular Research Group;   Massachusetts General Hospital;   Pacific Clinical Research Group
Completed - verified July 2017

Effects of a Self-Management Group-Intervention on Participation in Post-Stroke Patients.

Condition:   Stroke
Interventions:   Behavioral: Self-Management group-intervention;   Behavioral: Standard Care
Sponsors:   Uzi Milman;   University of Haifa
Recruiting - verified July 2017

Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID)-2.0

Condition:   Hypertension
Intervention:  
Sponsors:   National Human Genome Research Institute (NHGRI);   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified January 24, 2017

ETREAT Study on Effectiveness of Botulinum Toxin Type A Injections to Treat Post-stroke Upper and/or Lower Limb Spasticity

Condition:   Spasticity
Intervention:  
Sponsor:   Ipsen
Active, not recruiting - verified July 2017

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified July 2017

Decompressive Hemicraniectomy in Intracerebral Hemorrhage

Condition:   Cerebral Hemorrhage
Interventions:   Procedure: Decompressive craniectomy (DC) and best medical treatment;   Procedure: Best medical treatment
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified July 2017

Drug Persistence/Adherence in Patients Treated With Dabigatran or VKA for Stroke Prevention in Non Valvular Atrial Fibrillation (SPAF)

Condition:   Atrial Fibrillation
Interventions:   Drug: Dabigatran etexilate;   Drug: Phenprocoumon
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified July 2017

Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

Conditions:   Stroke;   Secondary Prevention
Interventions:   Drug: optional ASA as comedication;   Drug: placebo to ASA;   Drug: placebo to optional ASA as comedication;   Drug: placebo to dabigatran etexilate;   Drug: ASA 100 mg;   Drug: dabigatran etexilate
Sponsor:   Boehringer Ingelheim
Recruiting - verified July 2017

"Preventing Cardiovascular Ischemic Events and Arresting Their Consequences in Type 2 Diabetic Population

Conditions:   Type2 Diabetes Mellitus;   Microangiopathy;   Non Alcoholic Fatty Liver Disease;   Coronary Artery Disease;   Cerebrovascular Disease;   Acute Coronary Syndrome/ Myocardial Infarction;   Ictus
Intervention:  
Sponsor:   Hospital Universitari Vall d'Hebron Research Institute
Active, not recruiting - verified March 2017

The Effects of tDCS Combined With Balance Training on Postural Control in Chronic Stroke Patients

Condition:   Ischemic Stroke
Interventions:   Device: Transcranial direct current stimulation (tDCS);   Device: Sham
Sponsor:   Shahid Beheshti University of Medical Sciences
Recruiting - verified July 2017

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease, on Dialysis

Condition:   Anemia
Interventions:   Drug: Roxadustat;   Drug: Epoetin alfa
Sponsors:   AstraZeneca;   FibroGen
Recruiting - verified July 2017

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease (CKD), Not on Dialysis

Condition:   Anemia
Interventions:   Drug: Roxadustat;   Drug: Placebo
Sponsors:   AstraZeneca;   FibroGen
Active, not recruiting - verified July 2017

Mechanisms of Early Recurrence in Intracranial Atherosclerotic Disease

Condition:   Intracranial Vascular Disorders
Intervention:  
Sponsors:   University of Miami;   University of California, Los Angeles;   Northwestern University;   Emory University;   Baystate Medical Center
Recruiting - verified July 2017

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy (CEA);   Device: Carotid Stenting (CAS);   Other: Intensive Medical Management - no CEA;   Other: Intensive Medical Management - no CAS
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 2017

Detecting and Treating High Blood Pressure in Aboriginal Population and Low and Middle Income Countries

Conditions:   Hypertension;   Cardiovascular Disease;   Diabetes
Intervention:   Other: SMS text messaging
Sponsors:   Sunnybrook Health Sciences Centre;   Canadian Institutes of Health Research (CIHR)
Recruiting - verified July 2017

Elite Controller and ART-treated HIV+ Statin Versus ASA Treatment Intervention Study

Condition:   HIV Infection
Interventions:   Drug: Aspirin 81 mg daily;   Drug: Atorvastatin 40 mg daily
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified July 12, 2017

Outcomes of Angiotensin Converting Enzyme Inhibitor Management Strategies Prior to Coronary Artery Bypass

Condition:   Coronary Artery Disease
Interventions:   Drug: ACE/ARB continuation;   Drug: ACE/ARB withdrawal
Sponsor:   University of Alberta
Active, not recruiting - verified July 2017

Understanding the Exercise-Hypertension Paradox

Condition:   Hypertension
Interventions:   Dietary Supplement: Oral Antioxidant;   Other: Exercise rehabilitation
Sponsor:   VA Office of Research and Development
Recruiting - verified July 2017

Neuroprotection With Statin Therapy for Acute Recovery Trial Phase 2

Conditions:   Stroke;   Rhabdomyolysis;   Jaundice
Interventions:   Drug: Low Dose Lovastatin;   Other: Placebo;   Drug: High Dose Lovastatin
Sponsors:   Mitchell S Elkind;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified July 2017

Biomarkers and Perfusion - Training-Induced Changes After Stroke

Condition:   Stroke
Intervention:  
Sponsor:   Charite University, Berlin, Germany
Active, not recruiting - verified January 2017

Evaluation of the Efficiency of Word Prediction Software to Text Input Speed for Tetraplegia

Conditions:   Settings Word Prediction Software;   Rehabilitation Program
Interventions:   Other: Rehabilitation program;   Other: Self - Training at home;   Other: No treatment
Sponsor:   Centre d'Investigation Clinique et Technologique 805
Completed - verified July 2017

Skeletal Muscle Biomarkers in People With Fragile Sarcolemmal Muscular Dystrophy

Condition:   Genetic Disorder
Intervention:  
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institutes of Health Clinical Center (CC);   University of Massachusetts, Worcester
Recruiting - verified July 13, 2017

Examining How Motor Rehabilitation Promotes Brain Reorganization Following Stroke, an MRI Study

Conditions:   Stroke;   Hemiparesis
Intervention:   Behavioral: CI therapy
Sponsor:   Lynne Gauthier , PhD
Active, not recruiting - verified July 2017

Stroke Prevention and Rhythm Interventions in Atrial Fibrillation

Condition:   Cardiovascular Diseases
Intervention:  
Sponsors:   Canadian Collaborative Research Network;   Bayer
Active, not recruiting - verified July 2017

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified July 2017

Brain P-gp and Inflammation in People With Epilepsy

Condition:   Epilepsies, Partial
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 10, 2017

Determination of CRIM Status and Longitudinal Follow-up of Individuals With Pompe Disease

Condition:   Pompe Disease
Intervention:   Other: Observational
Sponsors:   Duke University;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified July 2017

Patient-Partner Stress Management Effects on Chronic Fatigue Syndrome Symptoms and Neuroimmune Process

Condition:   Chronic Fatigue Syndrome
Interventions:   Behavioral: Patient-Partner Videotelephone-delivered Health Information (PP-T-HI);   Behavioral: Patient-Partner Videotelephone-delivered Cognitive Behavioral Stress Management intervention (PP-T-CBSM)
Sponsors:   University of Miami;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified July 2017

Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial)

Conditions:   Mitral Regurgitation;   Mitral Valve Regurgitation;   Treatment of Functional Mitral Regurgitation in Symptomatic Heart Failure Subjects;   Heart Failure
Intervention:   Device: MitraClip System
Sponsors:   Evalve;   Abbott Vascular
Recruiting - verified July 2017

Music Therapy/Physical Therapy Intervention to Enhance Well-being and Functional Recovery Post-stroke

Condition:   Stroke With Hemiparesis
Intervention:   Other: Music & Physical Therapy
Sponsors:   New York University School of Medicine;   New York University
Completed - verified July 2017

Botulinum Toxin for Pelvic Pain in Women With Endometriosis

Conditions:   Endometriosis;   Botulinum Toxin A;   Chronic Pelvic Pain;   Pelvic Muscle Spasms;   Quality of Life
Intervention:   Drug: Botuninum toxin A
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 22, 2017

Bone Marrow Transplantation in Young Adults With Severe Sickle Cell Disease

Condition:   Sickle Cell Disease
Intervention:   Drug: Conditioning Regimen with Bone Marrow Transplant
Sponsors:   Emory University;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified July 2017

Efficacy and Safety of MRI-based Thrombolysis in Wake-up Stroke

Condition:   Stroke
Interventions:   Drug: Alteplase;   Drug: Placebo
Sponsor:   Universitätsklinikum Hamburg-Eppendorf
Active, not recruiting - verified July 2017

Studying Motor Neuron Tests

Conditions:   Magnetic Resonance Imaging;   Central Nervous System;   Volunteer;   Neurological Disorder
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 11, 2017

Study to Assess the Safety and Effects of Autologous Adipose-Derived Stromal Cells in Patients After Stroke

Condition:   Stroke
Intervention:   Procedure: Harvesting and Isolation of Stem Cells
Sponsors:   Ageless Regenerative Institute;   Instituto de Medicina Regenerativa, S.A. de C.V.
Withdrawn - verified July 2017

Identification of Carotid Vasa Vasorum and Correlation With Acute Coronary Events

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   University of Pittsburgh;   Lantheus Medical Imaging
Completed - verified July 2017

Surgery as a Treatment for Medically Intractable Epilepsy

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Partial Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 11, 2017

A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis

Condition:   Relapsing Multiple Sclerosis
Interventions:   Drug: Interferon beta-1a;   Drug: Ocrelizumab-matching placebo;   Drug: Ocrelizumab;   Drug: Interferon beta-1a-matching placebo
Sponsor:   Hoffmann-La Roche
Active, not recruiting - verified July 2017

Quantitative Imaging and Proton Spectroscopy in Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:   Device: Magnetic Resonance Imaging
Sponsors:   New York University School of Medicine;   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified July 2017

Trial and Cost Effectiveness Evaluation of Intra-arterial Thrombectomy in Acute Ischemic Stroke

Conditions:   Cerebral Stroke;   Cerebrovascular Accident
Interventions:   Drug: Alteplase (rt-PA)/Actilyse;   Procedure: Mechanic thrombectomy (MERCI, PENUMBRA, CATCH, SOLITAIRE)
Sponsor:   Central Hospital, Nancy, France
Terminated - verified July 2017

Aspirin in Reducing Events in the Elderly

Conditions:   Functional Disability;   Dementia;   Heart Disease;   Stroke;   Cancer;   Bleeding;   Depression
Interventions:   Drug: 100 mg enteric-coated aspirin;   Drug: Placebo
Sponsors:   Minneapolis Medical Research Foundation;   National Health and Medical Research Council, Australia;   Bayer;   Monash University;   Berman Center for Outcomes and Clinical Research;   National Institute on Aging (NIA)
Active, not recruiting - verified July 2017

Support for Cardiovascular Health in African American Primary Care Patients

Conditions:   Cardiovascular Diseases;   Blood Pressure
Interventions:   Behavioral: Peer Coach Phone Calls;   Behavioral: Health Educator Visits;   Other: written materials
Sponsors:   University of Pennsylvania;   Robert Wood Johnson Foundation;   Pfizer
Completed - verified July 2017

Trial of Aerobic Exercise Training in Stroke Survivors

Conditions:   Stroke;   Insulin Resistance;   Sedentary Lifestyle
Interventions:   Behavioral: Aerobic Exercise;   Behavioral: Stretching
Sponsors:   Baltimore VA Medical Center;   National Institute on Aging (NIA)
Recruiting - verified July 2017

Acarbose Cardiovascular Evaluation Trial

Conditions:   Coronary Heart Disease;   Acute Coronary Syndrome;   Impaired Glucose Tolerance;   Type 2 Diabetes Mellitus (T2DM)
Interventions:   Drug: Acarbose;   Drug: Matching Placebo
Sponsors:   University of Oxford;   Bayer
Completed - verified July 2017

Blood Markers of Inflammation, Blood Clotting and Blood Vessel Function in HIV-infected Adults

Condition:   HIV
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified July 11, 2017

Phase 2 Study of the Safety, Tolerability and Pilot Efficacy of Oral Factor Xa Inhibitor Betrixaban Compared to Warfarin

Condition:   Atrial Fibrillation
Interventions:   Drug: betrixaban;   Drug: Warfarin
Sponsor:   Portola Pharmaceuticals
Completed - verified July 2017

Genetic and Environmental Risk Factors for Hemorrhagic Stroke

Condition:   Stroke
Intervention:  
Sponsors:   University of Cincinnati;   National Institute of Neurological Disorders and Stroke (NINDS);   University of Maryland;   Massachusetts General Hospital;   Duke University, Durham, NC
Recruiting - verified July 2017

Anti-MAG First Administration to Human

Condition:   Cerebrovascular Accident
Interventions:   Drug: GSK249320A;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Completed - verified July 2017

Edwards Lifesciences Self-Expanding Stent Peripheral Vascular Disease Study

Conditions:   Intermittent Claudication;   Atherosclerotic Disease;   Arterial Occlusive Disease
Interventions:   Other: Percutaneous Transluminal Angioplasty;   Device: LifeStent NT™ Self-Expanding Peripheral Stent
Sponsors:   C. R. Bard;   CardioVascular Research Foundation, Korea
Completed - verified July 2017

Evaluation of an Advanced Lower Extremity Neuroprostheses

Conditions:   Spinal Cord Injuries;   Stroke;   Paralysis;   Tetraplegia;   Paraplegia
Intervention:   Device: IST-16 (16-channel implanted stimulator-telemeter)
Sponsors:   Case Western Reserve University;   National Institutes of Health (NIH);   VA Office of Research and Development
Recruiting - verified July 2017

Levels of Inflammatory Markers in the Treatment of Stroke—An SPS3 Ancillary Study

Conditions:   Hypertension;   Stroke
Intervention:  
Sponsors:   Columbia University;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified July 2017

A Study of the Effects of Minocycline on Cognitive Function After Carotid Endarterectomy

Condition:   Carotid Stenosis
Interventions:   Drug: Minocycline;   Drug: Placebo oral capsule
Sponsor:   Brigham and Women's Hospital
Withdrawn - verified July 2017

Training for Diagnosing Neurological Disorders

Condition:   Musculoskeletal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 6, 2017

Evaluation of Primary Chronic Autonomic Failure

Condition:   Autonomic Nervous System Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 10, 2017

Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Heart Failure, Congestive;   Heart Diseases
Interventions:   Procedure: CABG surgery plus MED;   Drug: Active Medication Alone;   Procedure: CABG plus MED and SVR
Sponsors:   Duke University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified July 2017

Screening and Natural History: Primary Lateral Sclerosis and Related Disorders

Condition:   Primary Lateral Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified July 10, 2017

Nurses' Health Study (Cardiovascular Component)

Conditions:   Cardiovascular Diseases;   Diabetes Mellitus;   Coronary Disease;   Heart Diseases;   Cerebrovascular Accident;   Pulmonary Embolism;   Angina Pectoris;   Myocardial Infarction;   Menopause;   Postmenopause
Intervention:  
Sponsors:   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified July 2017

Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

Condition:   Multiple Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 11, 2017