Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Home-based Respiratory Training After Stroke

Condition:   Stroke
Interventions:   Other: Respiratory training;   Other: Control
Sponsor:   Federal University of Minas Gerais
Not yet recruiting - verified March 2015

Effect of California Tri-pull Taping Method on Shoulder Subluxation, Pain, Active Range of Motion and Upper Limb Functional Recovery After Stroke - A Pre Test Post Test Design

Condition:   Post Stroke Shoulder Subluxation
Intervention:   Other: california tri-pull taping
Sponsor:   Maharishi Markendeswar University
Completed - verified March 2015

A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion

Condition:   Stroke, Acute
Interventions:   Drug: Tenecteplase;   Drug: Antiplatelet treatment
Sponsor:   University of Calgary
Not yet recruiting - verified March 2015

Cord Blood Infusion for Ischemic Stroke

Condition:   Stroke
Intervention:   Biological: allogeneic umbilical cord blood
Sponsor:   Joanne Kurtzberg, MD
Not yet recruiting - verified March 2015

SONOlysis in Prevention of Brain InfaRctions During Internal Carotid Endarterectomy

Condition:   Internal Carotid Artery Stenosis
Intervention:   Device: sonolysis
Sponsors:   University Hospital Ostrava;   Military University Hospital, Prague;   Vitkovice Hospital, Ostrava;   Masaryk Hospital, Usti nad Labem;   České Budějovice Hospital;   University Hospital Hradec Kralove;   University Hospital Plzen, Plzen;   County Hospital Liberec, Liberec
Not yet recruiting - verified March 2015

Vascular Ultrasound Screening in Patients With Ischemic Cerebrovascular Disease: a Multi-center Registry Study

Condition:   Stroke
Intervention:  
Sponsors:   Xuanwu Hospital, Beijing;   The First Affiliated Hospital of Shanxi Medical University;   Liaocheng Brains Hospital;   Tianjin Huanhu Hospital;   Baotou City Central Hospital;   First Hospital of Jilin University;   First Affiliated Hospital of Harbin Medical University;   First Hospital of China Medical University;   LanZhou University;   First Affiliated Hospital of Xinjiang Medical University;   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School;   The First Affiliated Hospital of Soochow University;   Anhui Provincial Hospital;   Guangdong Provincial Hospital of Traditional Chinese Medicine;   Zhuhai  People's Hospital;   Fujian Provincial Hospital;   Mianyang Central Hospital;   The Second Affiliated Hospital of Kunming Medical University;   Brains Hospital of Hunan Province;   Henan Provincial Hospital;   Luoyang Central Hospital Affiliated to Zhengzhou University;   National Health and Family Planning Commission Stroke Prevention Engineering Committee
Not yet recruiting - verified March 2015

Late LTP-like Plasticity Effects of tDCS in Subacute Stroke Patients

Conditions:   Stroke;   Hemiparesis
Intervention:   Device: tDCS
Sponsor:   Erasmus Medical Center
Recruiting - verified March 2015

Late LTP-like Plasticity Effects of tDCS in Chronic Stroke Patients

Conditions:   Stroke;   Hemiparesis
Interventions:   Device: Sham;   Device: Conventional Paired tDCS;   Device: Conventional Unpaired tDCS;   Device: Late LTP-like Plasticity tDCS
Sponsor:   Erasmus Medical Center
Recruiting - verified March 2015

Neuroprotection in Patients Undergoing Aortic Valve Replacement

Conditions:   Aortic Stenosis;   Brain Infarction;   Cerebrovascular Accident;   Stroke
Intervention:   Device: Embol-X Embolic Protection Device
Sponsors:   Mount Sinai School of Medicine;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified March 2015

tDCS and Speech Therapy to Improve Aphasia

Conditions:   Aphasia, Global;   Stroke;   Transcranial Direct Current Stimulation;   Speech Therapy
Intervention:   Procedure: tDCS +  speech therapy
Sponsor:   Medical Park AG
Not yet recruiting - verified March 2015

Identification of Novel Molecular Markers for Cerebral Ischemia From Patients With Minor and Devastating Ischemic Injury

Condition:   Cerebral Ischemia
Intervention:  
Sponsors:   St. Joseph's Hospital and Medical Center, Phoenix;   Translational Genomics Research Institute, Phoenix, Arizona.;   National Institutes of Health (NIH)
Enrolling by invitation - verified March 2015

Community Participation Transition After Stroke

Condition:   Stroke
Interventions:   Behavioral: Education Group;   Behavioral: Home Modifications Group
Sponsor:   Washington University School of Medicine
Recruiting - verified March 2015

The Evaluation of Safety, Tolerability and Pharmacokinetics/Pharmacodynamics of JPI-289 in Healthy Male Volunteers

Condition:   Stroke
Interventions:   Drug: JPI-289;   Drug: Placebo
Sponsor:   Jeil Pharmaceutical Co., Ltd.
Not yet recruiting - verified March 2015

Effects of Proprioceptive Stimulation Under Visual Feedback in Patient With CRPS

Condition:   Complex Regional Pain Syndromes
Interventions:   Behavioral: Usual Physiotherapy;   Device: Gloreha device
Sponsor:   University Hospital of Ferrara
Recruiting - verified January 2015

Renal Denervation Using the Vessix Renal Denervation System for the Treatment of Hypertension (REDUCE HTN:REINFORCE)

Condition:   Hypertension
Interventions:   Device: Renal Denervation (Vessix);   Device: Renal Angiography
Sponsor:   Boston Scientific Corporation
Recruiting - verified March 2015

The Bicuspid Aortic Stenosis Following Transcatheter Aortic Valve Replacement Registry

Conditions:   Aortic Valve Stenosis;   Cardiovascular Diseases;   Heart Valve Diseases;   Bicuspid
Intervention:   Procedure: transcatheter aortic valve replacement
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea
Not yet recruiting - verified March 2015

Informal Caregivers ANSWERS

Conditions:   Stroke;   Traumatic Rain Injury
Interventions:   Behavioral: ANSWERS - Acquiring New Skills While Enhancing Remaining Strengths;   Other: Control
Sponsor:   Department of Veterans Affairs
Recruiting - verified March 2015

A Prospective Study of Medical Therapy Against Cryoballoon Ablation in Symptomatic Recent Onset Persistent AF

Condition:   Atrial Fibrillation
Interventions:   Device: single ablation (CryoBalloonAblation (CBA);   Drug: sequential drug adjustment (propafenone, sotalol or flecainide)
Sponsor:   University Hospital, Ghent
Not yet recruiting - verified March 2015

Pipeline™ Flex Embolization Device With Shield Technology™ Clinical Study

Condition:   Aneurysm
Intervention:  
Sponsor:   Covidien
Recruiting - verified March 2015

A Study of Bezafibrate in Mitochondrial Myopathy

Condition:   Mitochondrial Diseases
Intervention:   Drug: Bezafibrate
Sponsors:   Newcastle-upon-Tyne Hospitals NHS Trust;   Newcastle University
Not yet recruiting - verified March 2015

Assessing Cognitive fUnction and MEasuring the Cerebral circulatioN on HaemoDialysis

Conditions:   End-Stage Renal Disease;   Stroke;   Cognition Disorders
Intervention:   Other: Observing effect of routine HD
Sponsor:   NHS Greater Glasgow and Clyde
Not yet recruiting - verified March 2015

Home-based -Virtual Reality Intervention for Stroke Rehabilitation

Condition:   Stroke
Interventions:   Other: self-training using video-games;   Other: traditional self-training
Sponsors:   Sheba Medical Center;   European Commission
Recruiting - verified March 2015

tDCS Immediate Effect on Cardiorespiratory Parameters in Hemiparetics Adults Patients Due to Stroke.

Condition:   Stroke
Interventions:   Device: tDCS active;   Device: tDCS Sham
Sponsor:   University of Nove de Julho
Recruiting - verified March 2015

The Immediate Effect of Electrical Stimulation Transcranial Direct Current (tDCS) Associated With the Use of FES, in Muscle Activity of the Tibialis Anterior Muscle, Balance and Plantar Pressure Distribution of Individuals With Hemiparesis Due to Stroke

Condition:   STROKE
Interventions:   Device: Transcranial direct current stimulation (tDCS);   Device: Functional electrical stimulation (FES);   Device: Sham stimulation
Sponsors:   University of Nove de Julho;   Fundação de Amparo à Pesquisa do Estado de São Paulo
Recruiting - verified March 2015

Longitudinal Study of Intra-Uterine Growth Restriction

Conditions:   IUGR;   Pregnancy
Interventions:   Radiation: Ultrasound;   Radiation: MRI;   Procedure: Blood collection;   Behavioral: Neurological Function Assessment;   Procedure: Placental Analysis;   Procedure: Measurement of body fat
Sponsors:   University of Colorado, Denver;   The Perelman Family Foundation
Not yet recruiting - verified March 2015

Rate Control Therapy Evaluation in Permanent Atrial Fibrillation (RATE-AF)

Condition:   Permanent Atrial Fibrillation
Interventions:   Drug: Bisoprolol;   Drug: Digoxin
Sponsor:   University of Birmingham
Not yet recruiting - verified March 2015

A Multicenter, Randomized, Controlled Study to Assess Mitral vAlve reconsTrucTion for advancEd Insufficiency of Functional or iscHemic ORigiN

Condition:   Mitral Valve Insufficiency
Interventions:   Device: MitraClip system (Abbott Vascular, Menlo Park, USA);   Procedure: Reconstructive mitral valve surgery
Sponsors:   Universitätsklinikum Köln ;   Clinical Trials Center Cologne
Recruiting - verified February 2015

Home-Based Screening for Early Detection of Atrial Fibrillation in Primary Care Patients Aged 75 Years and Older

Conditions:   Atrial Fibrillation;   Hypertension
Intervention:   Device: Screening: Intervention - Atrial fibrillation screening (ZIO XT ECG monitor, Watch-BP)
Sponsors:   Population Health Research Institute;   Canadian Stroke Prevention Intervention Network (C-SPIN);   Canadian Institutes of Health Research  (CIHR);   Heart and Stroke Foundation of Canada;   Canadian Stroke Network;   Boehringer Ingelheim;   iRhythm Technologies, Inc.;   Microlife
Not yet recruiting - verified March 2015

Resistive Training Combined With Nutritional Therapy After Stroke

Condition:   Stroke
Interventions:   Other: Protein;   Other: Placebo
Sponsors:   Department of Veterans Affairs;   Baltimore VA Medical Center
Not yet recruiting - verified March 2015

Cognitive Dysfunction in Parkinson's Disease

Condition:   Parkinson's Disease
Interventions:   Device: Real TMS;   Device: Sham TMS
Sponsors:   University of Colorado, Denver;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2015

Combining Robotic-Assisted Therapy and Pharmacotherapy in Post-Stroke Rehabilitation

Condition:   Stroke
Interventions:   Drug: Placebo;   Drug: Levodopa / Carbidopa;   Device: Armeo
Sponsor:   Ross D. Zafonte, MD
Not yet recruiting - verified February 2015

Phenotype, Genotype & Biomarkers in ALS and Related Disorders

Conditions:   Amyotrophic Lateral Sclerosis;   Frontotemporal Dementia;   Primary Lateral Sclerosis;   Hereditary Spastic Paraplegia;   Progressive Muscular Atrophy;   Multisystem Proteinopathy
Intervention:  
Sponsors:   University of Miami;   National Institute of Neurological Disorders and Stroke (NINDS);   National Center for Advancing Translational Science (NCATS);   St. Jude Children's Research Hospital
Not yet recruiting - verified March 2015

Field Randomization of NA-1 Therapy in Early Responders

Condition:   Acute Cerebral Ischemia
Interventions:   Drug: NA-1;   Drug: Placebo
Sponsors:   NoNO Inc.;   Brain Canada;   Djavad Mowafaghian Centre for Brain Health;   Canadian Stroke Network;   St. Michael's Hospital, Toronto;   Sunnybrook Health Sciences Centre;   University Health Network, Toronto;   Trillium Health Centre;   Vancouver General Hospital;   University of Calgary;   Dalhousie University;   University of Toronto;   University of British Columbia
Recruiting - verified March 2015

Endothelial Function-guided Therapy Compared to Usual Care in Patients With NOCAD

Condition:   Coronary Atherosclerosis
Intervention:  
Sponsor:   Itamar-Medical, Israel
Not yet recruiting - verified March 2015

Gua Sha for Chronic Low Back Pain in Elderly

Condition:   Back Pain
Interventions:   Other: Gua sha;   Other: Hot pack
Sponsors:   The Hong Kong Polytechnic University;   Massachusetts General Hospital
Completed - verified March 2015

A Device for Rapid, Painless, Bedside Muscle Evaluation of Children

Condition:   Duchenne Muscular Dystrophy
Intervention:  
Sponsors:   Skulpt, Inc.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2015

Comparison of Success Rate of Totally Thoracoscopic Ablation Versus Hybrid Procedure in Patients With Persistent Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Procedure: Eletrophysiologic study
Sponsor:   Samsung Medical Center
Recruiting - verified March 2015

RuSsian RegisTry of Acute CoronaRy SyndromE TreAtMent and Approach in Dual Antiplatelet Therapy

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   AstraZeneca
Not yet recruiting - verified March 2015

ETREAT Study on Effectiveness of Botulinum Toxin Type A Injections to Treat Post-stroke Upper and/or Lower Limb Spasticity

Condition:   Spasticity
Intervention:  
Sponsor:   Ipsen
Recruiting - verified March 2015

A Study to Evaluate the Efficacy and Safety of Two Dose Strengths of Dalfampridine Extended Release Tablets for Treatment of Stable Walking Deficits in Post-Ischemic Stroke

Condition:   Post-Ischemic Stroke
Interventions:   Drug: Placebo;   Drug: dalfampridine-ER 7.5mg;   Drug: dalfampridine-ER 10mg
Sponsor:   Acorda Therapeutics
Recruiting - verified March 2015

Comparison of Hemodynamics Between Dexmedetomidine and Propofol for Sedation in Patients With Abdominal Surgery

Conditions:   Disorder; Mental, Sedative;   Pain, Postoperative;   Surgery
Interventions:   Drug: Propofol;   Drug: Dexmedetomidine
Sponsor:   National Taiwan University Hospital
Recruiting - verified March 2015

Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System

Condition:   Mitral Valve Regurgitation
Intervention:   Device: Mitral valve replacement
Sponsor:   Neovasc Inc.
Recruiting - verified March 2015

Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability

Conditions:   Chronic Troublesome Sialorrhea;   Cerebral Palsy;   Stroke;   Traumatic Brain Injury;   Intellectual Disability
Interventions:   Drug: IncobotulinumtoxinA;   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Recruiting - verified March 2015

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified March 2015

Decompressive Hemicraniectomy in Intracerebral Hemorrhage

Condition:   Cerebral Hemorrhage
Interventions:   Procedure: Decompressive craniectomy (DC) and best medical treatment;   Procedure: Best medical treatment
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified March 2015

Rehabilitation for Disabled Stroke Patients in Rural China

Condition:   Stroke
Intervention:   Other: Rehabilitation
Sponsor:   The George Institute for Global Health, China
Recruiting - verified March 2015

Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

Conditions:   Stroke;   Secondary Prevention
Interventions:   Drug: optional ASA as comedication;   Drug: placebo to ASA;   Drug: placebo to optional ASA as comedication;   Drug: placebo to dabigatran etexilate;   Drug: ASA 100 mg;   Drug: dabigatran etexilate
Sponsor:   Boehringer Ingelheim
Recruiting - verified March 2015

Superselective Administration of VErapamil During Recanalization in Acute Ischemic Stroke

Condition:   Ischemic Stroke
Intervention:   Drug: Verapamil
Sponsor:   University of Kentucky
Recruiting - verified March 2015

Extracorporeal Shock Wave Therapy (ESWT) for the Treatment of Spasticity in Persons With Spinal Cord Injury

Conditions:   Spinal Cord Injury;   Spasticity
Intervention:   Device: Duolith® SD 1 "T-Top" (Storz Medical AG, Switzerland)
Sponsor:   Swiss Paraplegic Centre Nottwil
Recruiting - verified March 2015

Efficacy of Levetiracetam in Oromandibular and Cranial Dystonia

Conditions:   Oromandibular Dystonia;   Cranial Dystonia
Intervention:   Drug: Levetiracetam
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified June 2014

Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)

Conditions:   Atrial Fibrillation;   Percutaneous Coronary Intervention
Interventions:   Drug: Dabigatran Etexilate 110mg;   Drug: Warfarin 3mg;   Drug: Aspirin;   Drug: Dabigatran Etexilate 150mg;   Drug: Clopidogrel or Ticagrelor;   Drug: Clopidogrel or Ticagrelor;   Drug: Warfarin 5mg;   Drug: Clopidogrel or Ticagrelor;   Drug: Warfarin 1mg
Sponsor:   Boehringer Ingelheim
Recruiting - verified March 2015

Safety and Efficacy of Subjects With Critical Limb Ischemia

Condition:   Critical Limb Ischemia
Intervention:   Genetic: HGF Plasmid (AMG0001)
Sponsor:   AnGes
Recruiting - verified March 2015

A Phase 3 Clinical Outcomes Study to Compare the Incidence of Major Adverse Cardiovascular Events in Subjects Presenting With Acute Coronary Syndrome Treated With Losmapimod Compared to Placebo (LATITUDE-TIMI 60)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Losmapimod 7.5 mg twice daily;   Drug: Placebo twice daily
Sponsors:   GlaxoSmithKline;   The TIMI Study Group
Recruiting - verified March 2015

Automated Administration of Fluids Guided by Dynamic Parameters and Cardiac Output During General Anesthesia

Condition:   Anesthesia
Intervention:   Device: Learning Intravenous Resuscitator (LIR) system
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Recruiting - verified March 2015

Helsinki Ultra-acute Stroke Biomarker Study

Condition:   Acute Stroke
Intervention:  
Sponsors:   Helsinki University Central Hospital;   HUS area Prehospital Emergency Service
Recruiting - verified March 2015

A Blinded Study to Evaluate Effect on Atrial Fibrillation Burden in Patients With Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Interventions:   Drug: BMS-919373;   Drug: Placebo (Matching with BMS-919373)
Sponsor:   Bristol-Myers Squibb
Recruiting - verified October 2014

Short-term Dual Anti Platelet Therapy in Patients With ACS Treated With the COMBO Dual-therapy Stent

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Treatment 3 months DAPT;   Drug: Treatment 12 months DAPT
Sponsor:   Diagram B.V.
Recruiting - verified March 2015

A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients

Conditions:   Heart Failure;   Respiratory Insufficiency;   Stroke Acute;   Infectious Diseases;   Rheumatic Diseases
Interventions:   Drug: Rivaroxaban, 10 mg;   Drug: Rivaroxaban, 7.5 mg;   Drug: Placebo
Sponsor:   Janssen Research & Development, LLC
Recruiting - verified March 2015

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy;   Device: Carotid stenting
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2015

Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions

Conditions:   Chronic Troublesome Sialorrhea;   Parkinson's Disease;   Post-stroke;   Traumatic Brain Injury
Interventions:   Drug: IncobotulinumtoxinA (100 Units);   Drug: IncobotulinumtoxinA (75 Units);   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Recruiting - verified March 2015

Efficacy and Safety of New Generation Drug Eluting Stents Associated With an Ultra Short Duration of Dual Antiplatelet Therapy. Design of the Short Duration of Dual antiplatElet Therapy With SyNergy II Stent in Patients Older Than 75 Years Undergoing Percutaneous Coronary Revascularization.

Conditions:   Stable Angina;   Silent Myocardial Ischemia;   Acute Coronary Syndrome
Interventions:   Procedure: Percutaneous Coronary Intervention (PCI) with short DAPT duration with Synergy II stent;   Procedure: Percutaneous Coronary Intervention (PCI) with short DAPT duration with Omega stent;   Procedure: Percutaneous Coronary Intervention (PCI) with short DAPT duration with Rebel stent
Sponsor:   Ceric Sàrl
Recruiting - verified December 2014

A Study of the Efficacy and Safety of Activase (Alteplase) in Patients With Mild Stroke (PRISMS)

Condition:   Brain Ischemia
Interventions:   Drug: alteplase [Activase];   Drug: alteplase placebo;   Drug: aspirin;   Drug: aspirin placebo
Sponsor:   Genentech, Inc.
Recruiting - verified March 2015

Investigation of the Use of Acupuncture for the Treatment of Spasticity in Chronic Stroke Participants

Condition:   Stroke
Interventions:   Other: Acupuncture;   Other: Sham needle
Sponsor:   Hamilton Health Sciences Corporation
Recruiting - verified March 2015

Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic VTE(Venous Thromboembolism)

Conditions:   Pulmonary Embolism;   Thromboembolism;   Thrombosis;   Venous Thrombosis;   Venous Thromboembolism
Interventions:   Drug: BAY 59-7939;   Drug: BAY 59-7939;   Drug: ASA
Sponsor:   Bayer
Recruiting - verified March 2015

Hemodynamic Effects on Cerebral Autoregulation in Acute Stroke

Condition:   Ischemic Stroke
Intervention:  
Sponsors:   Henry Ford Health System;   Wayne State University
Recruiting - verified March 2015

Study Of The Blood Thinner, Apixaban, For Patients Who Have An Abnormal Heart Rhythm (Atrial Fibrillation) And Expected To Have Treatment To Put Them Back Into A Normal Heart Rhythm (Cardioversion)

Condition:   Atrial Fibrillation
Interventions:   Drug: Apixaban;   Drug: Parenteral heparin and/or oral Vitamin K antagonist
Sponsors:   Pfizer;   Bristol-Myers Squibb
Recruiting - verified March 2015

Accuracy of Pulse Pressure Variation and of Pleth Variability Index to Predict the Response to a Fluid Challenge

Condition:   Fluid Responsiveness
Intervention:   Device: - Nexfin (Pulse Pressure Variation) - Radical 7 (Pleth Variability Index) - CardioQ (stroke volume)
Sponsor:   Hopital Foch
Recruiting - verified March 2015

Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency

Conditions:   Metabolic Disease;   Seizures
Interventions:   Drug: SGS-742;   Drug: Placebo
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 2013

Registry for Estimation of Warfarin and Rivaroxaban in Atrial Fibrillation Patients With Coronary Stent Implantation

Conditions:   Coronary Artery Disease;   Atrial Fibrillation;   Stroke;   Fetal Blood Loss
Intervention:   Drug: Warfarin or Rivaroxaban
Sponsors:   Fujita Health University;   Bayer Yakuhin, Ltd.
Recruiting - verified March 2015

Rehabilitation Boot Camp: Intensive Balance and Mobility Therapy for People With Acquired Brain Injury

Condition:   Brain Injuries
Intervention:   Behavioral: Boot Camp Balance Training
Sponsor:   University of Manitoba
Completed - verified December 2013

Stroke Feasibility Study

Conditions:   Atrial Fibrillation;   AFib
Intervention:   Device: AtriClip LAA Exclusion Device
Sponsor:   AtriCure, Inc.
Active, not recruiting - verified March 2015

Prevalence of Morbidity in Newly Diagnosed type2 Diabetes in Adults

Conditions:   Type2 Diabetes Mellitus;   Complications
Intervention:   Other: no specific treatment
Sponsors:   University of Algiers;   National Institute of public Health, Algeria;   Ain-Taya's hospital, Algiers;   Parnet's teaching Hospital, Algiers;   Mustapha Pacha's teaching hospital, Algiers;   Birtraria's teaching hospital, Algiers;   Bab el Oued's teaching hospital, Algiers
Completed - verified March 2015

A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Ticagrelor 90 mg;   Drug: Ticagrelor placebo
Sponsor:   AstraZeneca
Recruiting - verified March 2015

Cardiovascular Outcomes Following Treatment With Ertugliflozin in Participants With Type 2 Diabetes Mellitus and Established Vascular Disease (MK-8835-004)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Ertugliflozin;   Drug: Placebo
Sponsors:   Merck Sharp & Dohme Corp.;   Pfizer
Recruiting - verified March 2015

Efficacy and Safety Study of MYOBLOC® Followed by Open-Label Multiple-Treatment With MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adult Subjects

Condition:   Sialorrhea
Intervention:   Drug: MYOBLOC
Sponsor:   US WorldMeds LLC
Recruiting - verified March 2015

Adjunctive Everolimus (RAD 001) Therapy for Epilepsy in Children With Sturge-Weber Syndrome (SWS)

Condition:   Sturge Weber Syndrome
Intervention:   Drug: Everolimus
Sponsors:   Baylor College of Medicine;   Novartis Pharmaceuticals
Recruiting - verified March 2015

Evaluating Human-Machine Interfaces in a Robotic Thumb Orthosis

Conditions:   Hemiplegic Stroke;   Hemiplegic Cerebral Palsy
Intervention:   Device: Isolated Orthosis for Thumb Actuation (IOTA)
Sponsors:   Wyss Institute at Harvard University;   Children's Hospital Boston;   Deborah Munroe Noonan Memorial Research Fund
Active, not recruiting - verified March 2015

The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified March 2015

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified March 2015

Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Hyperlipidemia or Mixed Dyslipidemia at Risk of Cardiovascular Events

Condition:   Hyperlipidemia
Interventions:   Drug: Bococizumab (PF-04950615; RN316);   Other: Placebo
Sponsor:   Pfizer
Recruiting - verified March 2015

Biomarkers and Perfusion - Training-Induced Changes After Stroke

Condition:   Stroke
Intervention:  
Sponsor:   Charite University, Berlin, Germany
Recruiting - verified March 2015

Study of Stroke Related Edema Treatments

Conditions:   Acute Cerebrovascular Accident;   Cerebral Edema
Interventions:   Drug: Conivaptan;   Drug: Hypertonic saline;   Drug: Mannitol
Sponsor:   University of Florida
Not yet recruiting - verified March 2015

Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Stroke
Interventions:   Drug: Apixaban;   Drug: aspirin
Sponsors:   Population Health Research Institute;   Bristol-Myers Squibb;   Pfizer;   Medtronic
Not yet recruiting - verified March 2015

Compound Edaravone Injection for Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke
Interventions:   Drug: Compound Edaravone Injection;   Drug: Edaravone Injection
Sponsor:   Jiangsu Simcere Pharmaceutical Co., Ltd.
Completed - verified March 2015

Stroke Oral healthCare pLan Evaluation

Conditions:   Cerebrovascular Disorders;   Stroke;   Pneumonia;   Oral Hygiene
Intervention:   Other: Enhanced complex oral health care
Sponsors:   Glasgow Caledonian University;   Nursing Midwifery and Allied Health Profession (NMAHP) Research Unit;   University of Glasgow;   NHS Lanarkshire;   Glasgow Dental Hospital and School;   University of Edinburgh
Enrolling by invitation - verified March 2015

Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation

Condition:   Amyotrophic Lateral Sclerosis
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Aging (NIA)
Recruiting - verified May 2014

Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Placebo;   Drug: Linagliptin
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified March 2015

Omega-3 Supplementation for Tetraplegics With Poor Cholesterol Levels

Conditions:   Spinal Cord Injury;   Tetraplegia;   Quadraplegia;   Low HDL-c;   High LDL-c
Intervention:   Dietary Supplement: Omega-3 supplements
Sponsors:   University of Manitoba;   The Association of Rehabilitation Medicine in Manitoba
Recruiting - verified March 2015

A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure

Conditions:   Heart Failure;   Coronary Artery Disease
Interventions:   Drug: Rivaroxaban;   Drug: Placebo;   Other: Standard of care for heart failure and coronary artery disease
Sponsors:   Janssen Research & Development, LLC;   Bayer
Recruiting - verified March 2015

Cerebrospinal Fluid Collection and Repository Storage

Condition:   Neurological Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2014

The Influence of Pneumoperitoneum on Minimal Invasive Cardiac Output Measurements

Condition:   Pneumoperitoneum
Intervention:   Procedure: Pneumoperitoneum and SVV/PPV
Sponsor:   Haukeland University Hospital
Recruiting - verified March 2015

Arm Spasticity - Non-Interventional Study Early BIRD (BoNT Treatment: Initial and Repeated Documentation) [AS-NIS Early BIRD]

Condition:   Post-stroke Arm Spasticity
Intervention:  
Sponsor:   Ipsen
Recruiting - verified March 2015

Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage

Conditions:   Cerebrovascular Disorders;   Brain Lesions;   Degenerative Diseases;   Developmental Pathology
Interventions:   Behavioral: Neuropsychological testing;   Other: MRI
Sponsor:   University Hospital, Rouen
Recruiting - verified March 2015

Brain Integrity in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation

Condition:   Hodgkin Lymphoma
Interventions:   Other: Neurocognitive Evaluation;   Other: Quantitative Brain Imaging;   Other: Neurologic Evaluation;   Other: Health Questionnaire;   Other: Vascular Testing;   Other: Cardiopulmonary Exercise Testing;   Other: Echocardiography;   Other: Pulmonary Function Testing;   Procedure: Serum Biomarkers;   Other: Ophthalmology Examination;   Other: Sleep Assessment
Sponsors:   St. Jude Children's Research Hospital;   National Cancer Institute (NCI)
Recruiting - verified March 2015

Atrial Fibrillation (AF) and Physical Exercise

Condition:   Atrial Fibrillation
Intervention:   Other: Physical Exercise
Sponsors:   Hvidovre University Hospital;   Sygekassernes Helsefond;   Eva og Henry Frænkels Mindefond;   Sanofi;   Thorkild Steenbecks Legat;   Toyota-Fonden;   Snedkermester Sophus Jacobsen and hustru Astrid Jacobsens Foundation
Active, not recruiting - verified March 2015

Goal Directed Fluid Therapy and Postoperative Ileus

Condition:   Postoperative Ileus
Interventions:   Procedure: Goal Directed Fluid Therapy (GDFT)-Esophageal doppler guided;   Other: Standard fluid therapy
Sponsor:   Gabriele Baldini, MD, MSc, Assistant Professor
Recruiting - verified March 2015

A Study Exploring Two Strategies of Rivaroxaban (JNJ39039039; BAY-59-7939) and One of Oral Vitamin K Antagonist in Patients With Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention

Conditions:   Atrial Fibrillation;   Percutaneous Coronary Intervention
Interventions:   Drug: rivaroxaban 2.5 mg;   Drug: rivaroxaban 15 mg;   Drug: rivaroxaban 10 mg;   Drug: aspirin (ASA);   Drug: vitamin K antagonist (VKA);   Drug: clopidogrel;   Drug: prasugrel;   Drug: ticagrelor
Sponsors:   Janssen Scientific Affairs, LLC;   Bayer
Recruiting - verified March 2015

Pilot Study of Therapy With Hylan G-F 20 Exercise Capacity

Condition:   Knee Osteoarthritis
Interventions:   Device: Hylan G-F 20;   Other: Control
Sponsors:   OhioHealth;   Sanofi
Recruiting - verified March 2015

Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy

Condition:   Cerebral Amyloid Angiopathy
Interventions:   Biological: Ponezumab;   Other: placebo
Sponsor:   Pfizer
Recruiting - verified March 2015

Automated Hovering to Improve Medication Adherence Among Myocardial Infarction Patients (Heartstrong)

Condition:   Patients With Principal or Secondary Diagnosis Code of Intrntl Classification of Diseases, 9th Revision, (ICD-9-CM) 410 (Except When 5th Digit Was 2)
Intervention:   Behavioral: Electronic Pill Bottle, Incentives, Social Influence
Sponsor:   University of Pennsylvania
Active, not recruiting - verified April 2013

A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD)

Condition:   Sickle Cell Disease
Interventions:   Drug: Prasugrel;   Drug: Placebo
Sponsors:   Eli Lilly and Company;   Daiichi Sankyo Inc.
Recruiting - verified March 2015

Mindful Hearts Study

Conditions:   Cardiovascular Disease;   Psychological Stress;   Stroke;   Coronary Artery Disease
Interventions:   Behavioral: Mindfulness Based Stress Reduction;   Behavioral: Health Education Program
Sponsor:   Department of Veterans Affairs
Recruiting - verified March 2015

Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke

Condition:   Ischemic Stroke
Intervention:   Procedure: Endovascular thrombectomy/thrombolysis
Sponsors:   University of Calgary;   Covidien;   Heart and Stroke Foundation of Canada;   Hotchkiss Brain Institute, University of Calgary
Terminated - verified March 2015

Effect of Afferent Oropharyngeal Pharmacological and Electrical Stimulation on Swallow Response and on Activation of Human Cortex in Stroke Patients With Oropharyngeal Dysphagia

Conditions:   Dysphagia,;   Aspiration,;   Swallow Response,;   Videofluoroscopy,;   Sensorial Neurostimulation.
Interventions:   Behavioral: Dietary and oral hygiene recommendations;   Dietary Supplement: oral TRPV1 agonist;   Device: pharyngeal electrical stimulation;   Device: transcutaneous electrical stimulation
Sponsor:   Hospital de Mataró
Recruiting - verified March 2015

Erythropoietin + Iron Therapy for Anemic Patients Undergoing Aortic Valve Replacement

Conditions:   Anemia;   Aortic Stenosis
Interventions:   Drug: Erythropoietin;   Drug: Placebo
Sponsor:   Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Recruiting - verified March 2015

Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: semaglutide;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Active, not recruiting - verified March 2015

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified March 2015

Evaluating New Radiation Techniques for Cardiovascular Imaging

Condition:   Coronary Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2015

SONOlysis in Risk REduction of Symptomatic and Silent Brain infarCtions dUring Cardiac surgEry

Conditions:   Coronary Artery Bypass Graft Redo;   Heart Valve Diseases
Interventions:   Procedure: sonolysis;   Procedure: cardiac surgery
Sponsors:   University Hospital Ostrava;   Palacky University;   Ministry of Health, Czech Republic
Recruiting - verified March 2015

Xarelto [SPAF] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban(Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified March 2015

Xarelto [SPAF-QOL] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban (Xarelto_ BAY59-7939)
Sponsor:   Bayer
Recruiting - verified March 2015

Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.

Condition:   Smoking Cessation
Interventions:   Drug: placebo;   Drug: varenicline tartrate;   Drug: bupropion hydrochloride;   Drug: Nicotine Replacement Therapy Patch
Sponsor:   Pfizer
Recruiting - verified March 2015

Mechanical Stress Effects on the Cardiovascular Adaptations of Peripheral Arterial Calcifications Among Athletes

Condition:   Monckeberg Medial Calcific Sclerosis
Intervention:  
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Recruiting - verified March 2015

Losmapimod in Chronic Obstructive Pulmonary Disease Patients Stratified by Fibrinogen.

Condition:   Chronic Obstructive Pulmonary Disease
Interventions:   Drug: Losmapimod;   Drug: Placebo
Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   Technology Strategy Board;   GlaxoSmithKline;   Royal Brompton & Harefield NHS Foundation Trust;   University of Cambridge
Completed - verified March 2015

Studying Motor Neuron Tests

Conditions:   Magnetic Resonance Imaging;   Central Nervous System;   Volunteer;   Neurological Disorder
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2014

Coronary Hybrid Revascularisation Study

Condition:   Significant Coronary Artery Disease
Intervention:   Procedure: Combined CABG and PCI
Sponsor:   Aarhus University Hospital Skejby
Recruiting - verified March 2015

Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Spasticity in the Leg After a Stroke

Condition:   Post-stroke Spasticity of the Lower Limb.
Interventions:   Drug: IncobotulinumtoxinA (400 Units);   Drug: Placebo Comparator
Sponsor:   Merz Pharmaceuticals GmbH
Active, not recruiting - verified March 2015

GLORIA-AF Registry Program - Second and Third Phases

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified March 2015

Effect of HAART Vs. Statin Treatment on Endothelial Function and Inflammation/Coagulation

Condition:   HIV-1 Infection
Interventions:   Drug: Pravastatin sodium;   Drug: Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate;   Drug: Pravastatin sodium
Sponsors:   AIDS Clinical Trials Group;   National Institute of Allergy and Infectious Diseases (NIAID)
Withdrawn - verified March 2015

Carotid Artery Stenting Outcomes in the Standard Risk Population for Carotid Endarterectomy

Conditions:   Carotid Artery Disease;   Stroke;   Amaurosis Fugax;   Transient Ischemic Attack (TIA)
Intervention:   Device: RX Acculink Carotid Stent System (RX Acculink)
Sponsor:   Abbott Vascular
Active, not recruiting - verified March 2015

Mood and Insulin Resistance in Adolescents At-Risk for Diabetes

Conditions:   Depression;   Impaired Glucose Tolerance
Interventions:   Other: The Blues Program;   Other: Hey Durham
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   National Institutes of Health Clinical Center (CC)
Active, not recruiting - verified April 2014

Mifepristone for Metabolic Syndrome

Conditions:   Endocrine Disease;   Diabetes
Intervention:   Drug: Mifepristone
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified March 2015

Ticagrelor and Aspirin for the Prevention of Cardiovascular Events After Coronary Artery Bypass Surgery

Condition:   Coronary Artery Disease
Interventions:   Drug: ticagrelor;   Drug: Placebo
Sponsors:   Cardiology Research UBC;   University of British Columbia
Completed - verified March 2013

Effect of Functional Exercise in Patients With Spinal Bulbar Muscular Atrophy

Condition:   Motor Neuron Disease
Interventions:   Behavioral: A functional exercise program;   Behavioral: A stretching exercise program
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified March 2015

Effect of Speed-dependent Treadmill Training in Patients With Subacute Stroke

Condition:   Stroke
Interventions:   Other: Experimental;   Other: Speed-stable treadmill training
Sponsors:   The Hong Kong Polytechnic University;   Tung Wah Hospital
Completed - verified March 2015

A Study of RoActemra/Actemra (Tocilizumab) in Comparison to Etanercept in Patients With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors

Condition:   Cardiovascular Disease, Rheumatoid Arthritis
Interventions:   Drug: etanercept;   Drug: tocilizumab [RoActemra/Actemra]
Sponsor:   Hoffmann-La Roche
Active, not recruiting - verified March 2015

Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure

Conditions:   Hypertension;   Pure Autonomic Failure;   Multiple System Atrophy
Interventions:   Drug: Losartan;   Drug: Captopril;   Drug: Placebo
Sponsor:   Vanderbilt University
Recruiting - verified March 2015

Observation of the Gait Cycle in Patients With Hemiplegia in Order to Improve the Triggering of Functional Electrical Stimulation

Condition:   Stroke
Intervention:   Other: Gait analysis
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Completed - verified March 2015

CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: linagliptin;   Drug: glimepiride;   Drug: linagliptin placebo;   Drug: glimepride placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting - verified March 2015

A Prospective, Non-interventional Survey to Evaluate Injection Intervals and Treatment Modalities of Botulinum Toxin A (BoNT-A) in Adult Patients Suffering From Upper Limb Spasticity After Stroke

Condition:   Upper Limb Spasticity After Stroke
Intervention:  
Sponsor:   Ipsen
Active, not recruiting - verified March 2015

Behavioral Weight Loss as a Treatment for Migraine in Obese Women

Conditions:   Migraine;   Obesity
Interventions:   Behavioral: Behavioral Weight Loss Intervention;   Other: Migraine Education
Sponsors:   The Miriam Hospital;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2014

Comparison of Triflusal and Clopidogrel in Secondary Prevention of Stroke Based on the Genotyping

Condition:   Cerebral Infarction
Interventions:   Drug: Triflusal;   Drug: Clopidogrel
Sponsors:   Gangnam Severance Hospital;   Myung In Pharmaceutical Company;   Yonsei University
Completed - verified March 2015

BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME).

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: BI 10773 low dose;   Drug: Placebo BI 10773 high dose;   Drug: BI 10773 high dose;   Drug: Placebo BI 10773 low dose;   Drug: Placebo BI 10773 low dose;   Drug: Placebo BI 10773 high dose
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting - verified March 2015

Post-authorization Safety Study of Etoricoxib and Other Anti-inflammatory Therapies in European Patients With Ankylosing Spondylitis (MK-0663-163)

Condition:   Ankylosing Spondylitis
Intervention:  
Sponsor:   Merck Sharp & Dohme Corp.
Active, not recruiting - verified March 2015

The Natural History of Mucolipidosis Type IV

Condition:   Mucolipidosis Type IV
Intervention:  
Sponsors:   Baylor Research Institute;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2015

A Study With Aleglitazar in Patients With a Recent Acute Coronary Syndrome and Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Aleglitazar;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Completed - verified March 2015

International Active Surveillance Study - Safety of Contraceptives: Role of Estrogens

Condition:   Contraception
Intervention:  
Sponsors:   Center for Epidemiology and Health Research, Germany;   Bayer Healthcare Pharmaceuticals, Inc./Bayer Schering Pharma
Active, not recruiting - verified March 2015

Study of Immunotoxin, MR1-1

Condition:   Supratentorial Malignant Brain Tumor
Intervention:   Biological: MR1-1
Sponsors:   Darell D. Bigner, MD, PhD;   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified March 2015

Global Study to Assess the Safety and Effectiveness of Edoxaban (DU-176b) vs Standard Practice of Dosing With Warfarin in Patients With Atrial Fibrillation

Conditions:   Stroke;   Atrial Fibrillation;   Embolism
Interventions:   Drug: warfarin tablets;   Drug: Edoxaban tablets (high dose regimen-60mg);   Drug: Edoxaban tablets (low dose regimen-30mg);   Drug: placebo warfarin;   Drug: placebo edoxaban
Sponsors:   Daiichi Sankyo Inc.;   The TIMI Study Group
Completed - verified March 2015

A Study of All-Cause Mortality and Cardiovascular Morbidity in CKD Patients on Dialysis and Those Not on Renal Replacement Therapy Receiving Mircera or Reference ESAs.

Condition:   Anemia
Interventions:   Drug: ESAs (darbepoetin alfa, epoetin alfa or epoetin beta);   Drug: methoxy polyethylene glycol-epoetin beta [Mircera];   Drug: methoxy polyethylene glycol-epoetin beta [Mircera]
Sponsor:   Hoffmann-La Roche
Active, not recruiting - verified March 2015

Biomarkers of Risk of Parkinson Disease

Conditions:   Parkinson Disease;   Autonomic Nervous System Diseases;   Pure Autonomic Failure
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2015

Hepatitis C Treatment and Atherosclerosis

Conditions:   Chronic Hepatitis C;   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed - verified March 2015

A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease

Condition:   Moderate Risk of CVD
Interventions:   Drug: Aspirin (Acetylsalicylic acid, BAYE4465);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting - verified March 2015

A Study to Assess the Safety of a Potential New Drug in Comparison to the Standard Practice of Dosing With Warfarin for Non-valvular Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Thromboembolism
Interventions:   Drug: Edoxaban (DU-176b);   Drug: Edoxaban (DU-176b);   Drug: Edoxaban (DU-176b);   Drug: Edoxaban (DU-176b);   Drug: warfarin
Sponsor:   Daiichi Sankyo Inc.
Completed - verified March 2015

hsCRP in Japan Statin Treatment Against Recurrent Stroke (J-STARS hsCRP)

Condition:   Ischemic Stroke
Intervention:   Drug: Statin
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Ministry of Health, Labour and Welfare, Japan;   Hiroshima University;   Osaka University
Active, not recruiting - verified March 2015

Carotid Intima-media Thickness in Japan Statin Treatment Against Recurrent Stroke(J-STARS Echo)

Condition:   Ischemic Stroke
Intervention:   Drug: Statin
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Ministry of Health, Labour and Welfare, Japan;   Hiroshima University;   National Cerebral and Cardiovascular Center
Active, not recruiting - verified March 2015

Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

Condition:   HTLV-1
Intervention:   Drug: Hu MiK-Beta-1
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Suspended - verified April 2014

Vision Testing in Patients With Partial Seizures Receiving Either Lyrica or Placebo

Condition:   Epilepsies, Partial
Interventions:   Drug: Lyrica (pregabalin);   Drug: placebo
Sponsor:   Pfizer
Recruiting - verified March 2015

Japan Statin Treatment Against Recurrent Stroke (J-STARS)

Condition:   Ischemic Stroke
Intervention:   Drug: Pravastatin
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Ministry of Health, Labour and Welfare, Japan;   Hiroshima University
Active, not recruiting - verified March 2015

Genetic Studies of Lysosomal Storage Disorders

Conditions:   Gaucher's Disease;   Lysosomal Storage Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Enrolling by invitation - verified March 2015

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