Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Atrial Tachycardia as a Predictor of Atrial Fibrillation, Stroke and Mortality in Cryptogenic Stroke

Conditions:   Cryptogenic Stroke;   Atrial Fibrillation;   Atrial Tachycardia
Intervention:   Other: follow-up
Sponsor:   Corporacion Parc Tauli
Active, not recruiting - verified February 2015

Multimodal MRI Study of Ischemic Stroke

Condition:   STROKE
Intervention:   Device: MULTIMODAL MRI
Sponsor:   Assistance Publique Hopitaux De Marseille
Recruiting - verified February 2015

Effect of SVV Guided Fluid Therapy on Blood Loss and Postoperative Outcomes

Condition:   Bladder Cancer
Interventions:   Other: crystalloid;   Other: colloid;   Other: mannitol;   Other: lasix
Sponsor:   Asan Medical Center
Not yet recruiting - verified February 2015

A Multicenter, Randomized, Controlled Study to Assess Mitral vAlve reconsTrucTion for advancEd Insufficiency of Functional or iscHemic ORigiN

Condition:   Mitral Valve Insufficiency
Interventions:   Device: MitraClip system (Abbott Vascular, Menlo Park, USA);   Procedure: Reconstructive mitral valve surgery
Sponsors:   Universitätsklinikum Köln ;   Clinical Trials Center Cologne
Not yet recruiting - verified February 2015

Sensory-Motor Rehabilitation Post Stroke

Condition:   Stroke
Intervention:   Device: IntelliStretch rehabilitation robot
Sponsors:   Rehabilitation Institute of Chicago;   Northwestern University;   Northwestern Memorial Hospital
Recruiting - verified February 2015

Feasibility of the Portable YouGrabber System

Conditions:   Cerebral Palsy;   Stroke;   Traumatic Brain Injury;   Meningomyelocele;   Central Nervous System Diseases
Intervention:   Device: YouGrabber
Sponsor:   University Children's Hospital, Zurich
Recruiting - verified February 2015

Point-of-Care Testing of Coagulation in Patients Treated With Direct Oral Anticoagulants 1

Condition:   Anticoagulation With Direct Oral Anticoagulants
Intervention:  
Sponsors:   University Hospital Tuebingen;   Heart and Diabetes Center NRW, Bad Oeynhausen
Completed - verified February 2015

Point-of-Care Testing of Coagulation in Patients Treated With Direct Oral Anticoagulants 2

Condition:   Anticoagulation With Direct Oral Anticoagulants
Intervention:  
Sponsors:   University Hospital Tuebingen;   Heart and Diabetes Center NRW, Bad Oeynhausen
Active, not recruiting - verified February 2015

Benefits of Exercise Training in Women With Ischemic Syndrome

Condition:   Microvascular Coronary Dysfunction
Intervention:   Behavioral: Exercise training
Sponsor:   Cedars-Sinai Medical Center
Not yet recruiting - verified February 2015

Hemodynamic Stability of Bupivacaine With and Without Adrenaline for Paracervical Block for Cervical Conization

Condition:   Cervical Intraepithelial Neoplasia
Interventions:   Drug: Bupivacaine;   Drug: Adrenaline
Sponsor:   Helse Fonna
Not yet recruiting - verified February 2015

Effects of Constraint-induced Therapy for the Scapular Kinematics in Patients With Severe Chronic Hemiparesis

Condition:   Stroke
Interventions:   Other: Constraint Induced Therapy;   Other: Control
Sponsors:   Universidade Federal de Sao Carlos;   Conselho Nacional de Desenvolvimento Científico e Tecnológico
Recruiting - verified February 2015

Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects

Condition:   Familial Frontotemporal Dementia
Intervention:  
Sponsors:   Mayo Clinic;   National Institute on Aging (NIA);   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified February 2015

A Safety and Efficacy Study of BCD-080 Compared to Clexan for Deep Vein Thrombosis Prophylaxis at Orthopedic Surgeries

Condition:   Deep Vein Thrombosis
Intervention:   Drug: Sodium Enoxaparine
Sponsor:   Biocad
Recruiting - verified January 2015

Uninterrupted Dabigatran Etexilate in Comparison to Uninterrupted Warfarin in Pulmonary Vein Ablation (RE-CIRCUIT)

Condition:   Atrial Fibrillation
Interventions:   Drug: Warfarin;   Drug: Dabigatran Etexilate 150mg
Sponsor:   Boehringer Ingelheim
Not yet recruiting - verified February 2015

Quality of Life and Rehabilitation Pathway in Northern Norway and Denmark.

Conditions:   Stroke;   Rehabilitation;   Quality of Life
Intervention:  
Sponsor:   University Hospital of North Norway
Recruiting - verified February 2015

Weight Loss Referral for Healthier Survivorship in Obese Stage I-II Endometrial Cancer Survivors or Atypical Hyperplasia

Conditions:   Complex Endometrial Hyperplasia With Atypia;   Stage IA Uterine Corpus Cancer;   Stage IB Uterine Corpus Cancer;   Stage II Uterine Corpus Cancer
Interventions:   Behavioral: Weight Loss Specialist;   Other: Quality-of-Life Assessment;   Other: Medical Chart Review
Sponsors:   Case Comprehensive Cancer Center;   National Cancer Institute (NCI)
Recruiting - verified February 2015

Study to Assess Impact of Dysport Injections Early After Stroke on Upper Limb Spasticity Progression

Conditions:   Stroke;   Upper Limb Spasticity
Interventions:   Drug: AbobotulinumtoxinA;   Drug: Placebo
Sponsor:   Ipsen
Recruiting - verified February 2015

Combining Robotic-Assisted Therapy and Pharmacotherapy in Post-Stroke Rehabilitation

Condition:   Stroke
Interventions:   Drug: Placebo;   Drug: Levodopa / Carbidopa;   Device: Armeo
Sponsor:   Ross D. Zafonte, MD
Not yet recruiting - verified February 2015

Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)

Condition:   Stroke
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin (Acetylsalicylic acid, BAY1019036);   Other: Rivaroxaban-Placebo;   Other: Aspirin-Placebo
Sponsors:   Bayer;   Janssen, LP;   Hamilton Health Sciences Cooperation, Population Health Research Institute
Recruiting - verified February 2015

Evaluation of Minimally Invasive Subcortical Parafascicular Access for Clot Evacuation

Condition:   Cerebral Hemorrhage
Intervention:  
Sponsor:   Amin B Kassam
Recruiting - verified February 2015

"GOLIATH" - General Or Local Anaestesia in Intra Arterial THerapy

Conditions:   Stroke;   Anesthesia;   Cerebral Revascularization
Intervention:   Procedure: Local anesthesia
Sponsors:   University of Aarhus;   Aarhus University Hospital
Not yet recruiting - verified December 2014

A Device for Rapid, Painless, Bedside Muscle Evaluation of Children

Condition:   Duchenne Muscular Dystrophy
Intervention:  
Sponsors:   Skulpt, Inc.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2015

Inflammation and Post-Stroke Depression

Conditions:   Stroke;   Acute Stroke
Intervention:  
Sponsor:   Rutgers, The State University of New Jersey
Active, not recruiting - verified February 2015

A Prospective Investigation of Pleth Variability Index (PVI) as a Dynamic Parameter of Fluid Responsiveness in Children

Condition:   Atrial Septal Defect
Intervention:   Procedure: Volume expansion
Sponsor:   Brian Schloss
Recruiting - verified February 2015

Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability

Conditions:   Chronic Troublesome Sialorrhea;   Cerebral Palsy;   Stroke;   Traumatic Brain Injury;   Intellectual Disability
Interventions:   Drug: IncobotulinumtoxinA;   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Recruiting - verified February 2015

Effects of Proximal and Distal Robot-assisted Therapy Combined With Functional Training

Condition:   Stroke
Interventions:   Device: proximal robot-assisted therapy;   Device: distal robot-assisted therapy;   Device: combined robot-assisted therapy;   Behavioral: individualized intensive therapy
Sponsor:   Chang Gung Memorial Hospital
Recruiting - verified February 2015

Efficacy Study of "Imaginative Distention", a Self Managed Tool to Cope With Fatigue,Insomnia and Stress in pw Insomnia and pw MS

Condition:   Multiple Sclerosis
Intervention:   Behavioral: "Imaginative Distention" technique
Sponsor:   Niguarda Hospital
Recruiting - verified February 2015

Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

Conditions:   Stroke;   Secondary Prevention
Interventions:   Drug: optional ASA as comedication;   Drug: placebo to ASA;   Drug: placebo to optional ASA as comedication;   Drug: placebo to dabigatran etexilate;   Drug: ASA 100 mg;   Drug: dabigatran etexilate
Sponsor:   Boehringer Ingelheim
Recruiting - verified February 2015

Safety Evaluation of 3K3A-APC in Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Biological: 3K3A-APC;   Drug: Placebo
Sponsors:   ZZ Biotech, LLC;   National Institute of Neurological Disorders and Stroke (NINDS);   Cedars-Sinai Medical Center;   Massachusetts General Hospital;   University of Iowa
Recruiting - verified December 2014

Community Stroke Intervention Study

Condition:   Stroke
Intervention:   Behavioral: Community Navigation and Rehabilitation Intervention
Sponsor:   McMaster University
Not yet recruiting - verified February 2015

Prehospital Management of Stroke Patients by Emergency Medical Services

Condition:   Stroke
Intervention:  
Sponsors:   Emergency Medical Services, Capital Region, Denmark;   University of Copenhagen;   Bispebjerg Hospital;   Glostrup University Hospital, Copenhagen;   TrygFonden, Denmark
Recruiting - verified February 2015

Neural Basis of Decision-Making Deficits in Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Center for Neuroscience and Regenerative Medicine, Uniformed Services University of Health Sciences
Recruiting - verified February 2015

Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)

Conditions:   Atrial Fibrillation;   Percutaneous Coronary Intervention
Interventions:   Drug: Dabigatran Etexilate 110mg;   Drug: Warfarin 3mg;   Drug: Aspirin;   Drug: Dabigatran Etexilate 150mg;   Drug: Clopidogrel or Ticagrelor;   Drug: Clopidogrel or Ticagrelor;   Drug: Warfarin 5mg;   Drug: Clopidogrel or Ticagrelor;   Drug: Warfarin 1mg
Sponsor:   Boehringer Ingelheim
Recruiting - verified February 2015

Thoratec Corporation HeartMate III™ CE Mark Clinical Investigation Plan

Condition:   Advanced Refractory Left Ventricular Heart Failure
Intervention:   Device: Left Ventricular Assist System (LVAS)
Sponsors:   Thoratec Corporation;   Center for Life Sciences (C3TK);   Emergo Group;   Krakow Cardiovascular Research Institute
Active, not recruiting - verified February 2015

Early Post-marketing Study of Eliquis (Apixaban)

Condition:   Non-valvular Atrial Fibrillation (NVAF)
Intervention:   Drug: Apixaban
Sponsor:   Bristol-Myers Squibb
Recruiting - verified February 2015

HEart and BRain Interfaces in Acute Ischemic Stroke

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsors:   Charite University, Berlin, Germany;   Center for Stroke Research Berlin;   Neurology, Charite University, Berlin, Germany
Recruiting - verified February 2015

A Phase 3 Clinical Outcomes Study to Compare the Incidence of Major Adverse Cardiovascular Events in Subjects Presenting With Acute Coronary Syndrome Treated With Losmapimod Compared to Placebo (LATITUDE-TIMI 60)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Losmapimod 7.5 mg twice daily;   Drug: Placebo twice daily
Sponsors:   GlaxoSmithKline;   The TIMI Study Group
Recruiting - verified February 2015

A Blinded Study to Evaluate Effect on Atrial Fibrillation Burden in Patients With Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Interventions:   Drug: BMS-919373;   Drug: Placebo (Matching with BMS-919373)
Sponsor:   Bristol-Myers Squibb
Recruiting - verified October 2014

Study of Hepatic Function in Patients With Spinal and Bulbar Muscular Atrophy

Conditions:   Liver;   Motor Neuron Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2014

Effects of tDCS on Quadriceps Strength After Stroke

Condition:   Stroke
Intervention:   Device: transcranial Direct current stimulation
Sponsors:   Centre d'Investigation Clinique et Technologique 805;   Fondation Garches
Recruiting - verified February 2015

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy;   Device: Carotid stenting
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2015

Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions

Conditions:   Chronic Troublesome Sialorrhea;   Parkinson's Disease;   Post-stroke;   Traumatic Brain Injury
Interventions:   Drug: IncobotulinumtoxinA (100 Units);   Drug: IncobotulinumtoxinA (75 Units);   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Recruiting - verified February 2015

Reflexive Coughing Force in Silent Aspirators

Condition:   Stroke
Intervention:  
Sponsor:   The Catholic University of Korea
Completed - verified February 2015

Evaluation of Effort and Time Efficiency of Surgical Theater's Surgery Rehearsal Platform (SRP) for Cerebral Aneurysm Clipping Surgery

Conditions:   Cerebral Aneurysm Unruptured;   Cerebral Aneurysm Ruptured
Interventions:   Other: Active SRP cases;   Other: Control cases
Sponsor:   University Hospital Case Medical Center
Active, not recruiting - verified February 2015

Coughing in Infratentorial Brain Lesion Patients

Condition:   Stroke
Intervention:   Other: Not applicable (observational study with no active intervention)
Sponsor:   The Catholic University of Korea
Completed - verified February 2015

A Study of the Efficacy and Safety of Activase (Alteplase) in Patients With Mild Stroke (PRISMS)

Condition:   Brain Ischemia
Interventions:   Drug: alteplase [Activase];   Drug: alteplase placebo;   Drug: aspirin;   Drug: aspirin placebo
Sponsor:   Genentech, Inc.
Recruiting - verified February 2015

Elite Controller and ART-treated HIV+ Statin Versus ASA Treatment Intervention Study

Condition:   HIV Infection
Interventions:   Drug: Aspirin 81 mg daily;   Drug: Atorvastatin 40 mg daily
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified September 2014

Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic VTE(Venous Thromboembolism)

Conditions:   Pulmonary Embolism;   Thromboembolism;   Thrombosis;   Venous Thrombosis;   Venous Thromboembolism
Interventions:   Drug: BAY 59-7939;   Drug: BAY 59-7939;   Drug: ASA
Sponsor:   Bayer
Recruiting - verified February 2015

Trevo® Retriever Registry Post Market Surveillance

Condition:   Ischemic Stroke
Intervention:  
Sponsor:   Stryker Neurovascular
Recruiting - verified February 2015

"Evaluation by Transcranial Magnetic Stimulation of the Benefit of Fluoxetine on Motor Recovery After Stroke"

Condition:   Cerebral Infarction
Interventions:   Drug: Fluoxetine;   Drug: Placebo of fluoxetine
Sponsor:   Centre Hospitalier St Anne
Recruiting - verified February 2015

Understanding the Exercise-Hypertension Paradox

Condition:   Hypertension
Interventions:   Dietary Supplement: Oral Antioxidant;   Other: Exercise rehabilitation
Sponsor:   Department of Veterans Affairs
Recruiting - verified February 2015

Open-Label, Dose-Escalating Study to Assess Safety, Tolerability, Efficacy, PK and PD of RP103 in Children With Inherited Mitochondrial Disease

Condition:   Inherited Mitochondrial Disease, Including Leigh Syndrome
Intervention:   Drug: Cysteamine Bitartrate Delayed-release Capsules (RP103)
Sponsor:   Raptor Pharmaceuticals Inc.
Recruiting - verified February 2015

Effects of Viral Reactivation on Outcomes of Brain-injured Patients ( IBIS-VIRUS)

Condition:   Brain Injury
Intervention:  
Sponsor:   Nantes University Hospital
Recruiting - verified December 2013

A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Ticagrelor 90 mg;   Drug: Ticagrelor placebo
Sponsor:   AstraZeneca
Recruiting - verified February 2015

Cardiovascular Outcomes Following Treatment With Ertugliflozin in Participants With Type 2 Diabetes Mellitus and Established Vascular Disease (MK-8835-004)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Ertugliflozin;   Drug: Placebo
Sponsors:   Merck Sharp & Dohme Corp.;   Pfizer
Recruiting - verified February 2015

Hip Fracture Impact on Vascular Events In Noncardiac Surgery patIents: a cOhort evaluatioN (Hip VISION): Pilot Study

Condition:   Hip Fractures
Intervention:  
Sponsor:   Population Health Research Institute
Active, not recruiting - verified February 2015

Proprioception Testing in Persons With Sensorimotor Impairment

Conditions:   Spinal Cord Injury;   Stroke;   Acquired Brain Injury
Intervention:   Device: AMES Therapy
Sponsor:   Oregon Health and Science University
Recruiting - verified February 2015

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified February 2015

A Dose-Escalation, Safety and Feasibility Study of Enteral Levetiracetam for Seizure Control in Pediatric Cerebral Malaria

Conditions:   Seizure;   Epilepsy;   Cerebral Malaria
Interventions:   Drug: Oral Levetiracetam;   Drug: Standard AED
Sponsors:   University of Rochester;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2015

Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Hyperlipidemia or Mixed Dyslipidemia at Risk of Cardiovascular Events

Condition:   Hyperlipidemia
Interventions:   Drug: Bococizumab (PF-04950615; RN316);   Other: Placebo
Sponsor:   Pfizer
Recruiting - verified February 2015

Electrical Pharyngeal Stimulation for Dysphagia Therapy in Tracheostomized Stroke Patients

Conditions:   Stroke;   Dysphagia
Interventions:   Device: Electrical pharyngeal stimulation;   Device: Sham stimulation
Sponsor:   University Hospital Muenster
Completed - verified February 2015

New Protocols in the Treatment of Upper Limb Dysfunctions of Patients With Stroke.

Condition:   Cerebral Vascular Accident
Interventions:   Other: intermittent theta burst stimulation;   Other: continuous theta burst stimulation;   Other: sham theta burst stimulation
Sponsor:   Chang Gung Memorial Hospital
Recruiting - verified November 2012

Efficacy of New Protocols in the Treatment of Upper Limb Dysfunctions in Patients With Cerebral Palsy

Condition:   Cerebral Palsy
Interventions:   Device: SES;   Device: VCT;   Device: VRCIT;   Device: traditional rehabilitation program
Sponsors:   Chang Gung Memorial Hospital;   National Science Council, Taiwan
Recruiting - verified April 2013

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Germany)

Condition:   Pulmonary Embolism
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Phenprocoumon
Sponsor:   Bayer
Recruiting - verified February 2015

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)

Condition:   Pulmonary Embolism
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Warfarin
Sponsor:   Bayer
Recruiting - verified February 2015

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)

Condition:   Pulmonary Embolism
Interventions:   Drug: Rivaroxoban (Xarelto, Bay59-7939);   Drug: Acenocoumarol
Sponsor:   Bayer
Recruiting - verified February 2015

AMES Treatment of the Proximal Arm in Chronic Stroke

Conditions:   Stroke;   Cerebrovascular Accident
Intervention:   Device: 30 PAAD treatments
Sponsors:   Oregon Health and Science University;   Oregon Community Foundation
Recruiting - verified February 2015

Strategies for Recovery of Dexterity Post Stroke

Condition:   Stroke With Hemiparesis
Intervention:   Other: Alternate Hand Training or Affected Hand Training
Sponsors:   New York University School of Medicine;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified February 2015

Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Placebo;   Drug: Linagliptin
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified February 2015

Renal Denervation in Patients After Acute Coronary Syndrome

Conditions:   Acute Coronary Syndrome;   Arterial Hypertension
Interventions:   Procedure: Renal denervation;   Drug: Metoprolol;   Drug: Lisinopril
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Recruiting - verified February 2015

A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure

Conditions:   Heart Failure;   Coronary Artery Disease
Interventions:   Drug: Rivaroxaban;   Drug: Placebo;   Other: Standard of care for heart failure and coronary artery disease
Sponsors:   Janssen Research & Development, LLC;   Bayer
Recruiting - verified February 2015

Mechanical Ventilation in Brain-injured Patients

Conditions:   Brain-injury;   Stroke;   Subarachnoid Haemorrhage;   Traumatic Brain Injury;   Structural Coma
Intervention:   Other: Pass recommendations on ventilation factors and extubation
Sponsor:   Nantes University Hospital
Completed - verified January 2015

Belgian Real Life Non-interventional Study (NIS) on Xarelto in Non-valvular Atrial Fibrillation (AF) Patients Treated for the Prevention of Stroke and Systemic Embolism

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsor:   Bayer
Completed - verified February 2015

Registry of Acute Stroke Under New Oral Anticoagulants -Pilot (RASUNOA-Pilot)

Conditions:   Ischemic Stroke;   Intracranial Hemorrhage
Intervention:  
Sponsor:   University Hospital Heidelberg
Active, not recruiting - verified February 2015

Exercise Education for Adults With Seizure Disorders

Conditions:   Seizures;   Epilepsy
Intervention:   Other: Patient Education
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2015

A Registry to Evaluate the Direct Flow Medical Transcatheter Aortic Valve System

Condition:   Aortic Valve Stenosis
Intervention:   Device: Aortic Valve Replacement
Sponsor:   Direct Flow Medical, Inc.
Recruiting - verified February 2015

Cerebral Oximetry and Perioperative Outcome in Non-Cardiac Surgery

Conditions:   High Risk Non-cardiac Surgery;   Death;   Delirium;   Kidney Injury;   Myocardial Infarction;   Respiratory Failure;   Postoperative Infection
Intervention:   Other: Observational study
Sponsors:   University of Manitoba;   Canadian Anesthesia Research Foundation
Recruiting - verified February 2015

A Study Exploring Two Strategies of Rivaroxaban (JNJ39039039; BAY-59-7939) and One of Oral Vitamin K Antagonist in Patients With Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention

Conditions:   Atrial Fibrillation;   Percutaneous Coronary Intervention
Interventions:   Drug: rivaroxaban 2.5 mg;   Drug: rivaroxaban 15 mg;   Drug: rivaroxaban 10 mg;   Drug: aspirin (ASA);   Drug: vitamin K antagonist (VKA);   Drug: clopidogrel;   Drug: prasugrel;   Drug: ticagrelor
Sponsors:   Janssen Scientific Affairs, LLC;   Bayer
Recruiting - verified February 2015

Safety, Tolerability and Effectiveness of Nuedexta in the Treatment of Pseudobulbar Affect (PBA)

Conditions:   Pseudobulbar Affect (PBA);   Stroke;   Dementia;   Traumatic Brain Injury (TBI)
Intervention:   Drug: Nuedexta (DM 20 mg/Q 10 mg)
Sponsors:   Avanir Pharmaceuticals;   OptumInsight Life Sciences
Active, not recruiting - verified February 2015

POC in Patients With Ischaemic Stroke

Condition:   Cerebrovascular Accident
Interventions:   Drug: GSK249320 100/mg;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Terminated - verified October 2014

Deep Brain Stimulation for Refractory Alcoholism

Condition:   Alcoholism
Intervention:   Procedure: Implantation of Deep Brain Stimulation
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Enrolling by invitation - verified January 2015

A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD)

Condition:   Sickle Cell Disease
Interventions:   Drug: Prasugrel;   Drug: Placebo
Sponsors:   Eli Lilly and Company;   Daiichi Sankyo Inc.
Recruiting - verified February 2015

Enoxaparin Versus Aspirin in Patients With Cancer and Stroke

Condition:   Cancer Patients First-ever Acute Ischemic Stroke
Interventions:   Drug: Enoxaparin;   Drug: Aspirin
Sponsors:   Memorial Sloan Kettering Cancer Center.;   New York Presbyterian Hospital;   Weill Medical College of Cornell University
Recruiting - verified February 2015

Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation in Asia

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified February 2015

Acetyl Hexapeptide-8 for Blepharospasm

Condition:   Focal Dystonia
Intervention:   Drug: Topical acetyl hexapeptide-8
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 2014

DETErmination of the Duration of the Dual Antiplatelet Therapy by the Degree of the Coverage of The Struts on Optical Coherence Tomography From the Randomized Comparison Between Everolimus-eluting Stents(EES) Versus Biolimus A9-eluting Stents(BES)

Condition:   Ischemic Heart Disease
Interventions:   Device: Angio-guided PCI with EES  or BES;   Device: OCT-guided PCI with EES  or BES;   Device: PCI with BES under angio-guide or OCT guide;   Device: PCI with EES under angio-guide or OCT guide;   Drug: Keep DAPT;   Drug: Discontinue DAPT
Sponsor:   Yonsei University
Recruiting - verified February 2015

Ponatinib as Second Line Therapy for Patients With Chronic Myeloid Leukemia in Chronic Phase Resistant or Intolerant to Imatinib, Dasatinib or Nilotinib

Condition:   Leukemia
Intervention:   Drug: Ponatinib
Sponsors:   M.D. Anderson Cancer Center;   Ariad Pharmaceuticals
Active, not recruiting - verified February 2015

A Study on The Potential of Aleglitazar to Reduce Cardiovascular Risk in Patients With Stable Cardiovascular Disease and Glucose Abnormalities

Condition:   Cardiovascular Disease, Diabetes Mellitus, Type 2
Interventions:   Drug: Placebo;   Drug: aleglitazar
Sponsor:   Hoffmann-La Roche
Completed - verified February 2015

Intracranial Hypertension and Optic Nerve Sheath Diameter

Conditions:   Cerebral Stroke;   Cerebral Venous Thrombosis
Intervention:   Other: ONSD ultrasound
Sponsor:   Hospices Civils de Lyon
Recruiting - verified February 2015

Neuroimaging Correlates of Memory Decline Following Carotid Interventions

Condition:   Carotid Artery Stenosis
Interventions:   Other: Magnetic resonance imaging;   Behavioral: Neuropsychological testing
Sponsor:   Stanford University
Recruiting - verified February 2015

Long-term Neurocognitive Sequelae of Subclinical Microembolization During Carotid Interventions

Condition:   Carotid Artery Stenosis
Intervention:   Behavioral: Neuropsychological testing
Sponsors:   Stanford University;   University of Wisconsin, Madison
Recruiting - verified February 2015

Left Atrial Appendage (LAA) Occluders After Catheter Ablation of Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Device: LAA occluder;   Procedure: RFA ablation;   Drug: Warfarin
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Recruiting - verified February 2015

A Study of Evacetrapib in High-Risk Vascular Disease

Condition:   Cardiovascular Diseases
Interventions:   Drug: Evacetrapib;   Drug: Placebo
Sponsors:   Eli Lilly and Company;   The Cleveland Clinic
Active, not recruiting - verified February 2015

Paired Vagus Nerve Stimulation (VNS) With Rehabilitation for Upper Limb Function Improvement After Stroke

Condition:   Stroke
Interventions:   Device: Vivistim System;   Other: Rehab Only
Sponsor:   MicroTransponder Inc.
Completed - verified February 2015

Hypothermia in Acute Ischemic Stroke - Surface Versus Endovascular Cooling (HAIS-SE)

Conditions:   Ischemic Stroke;   Thrombolysis;   Hypothermia
Interventions:   Device: ZOLL Thermogard XP;   Device: BARD/Medivance Arctic Sun 5000
Sponsors:   University Hospital Heidelberg;   ZOLL Circulation, Inc., USA
Active, not recruiting - verified June 2013

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab SAR236553 (REGN727)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Other: placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified February 2015

Solitaire With the Intention For Thrombectomy as PRIMary Endovascular Treatment (SWIFT PRIME) Trial

Condition:   Acute Ischemic Stroke
Interventions:   Drug: intravenous (IV) recombinant human tissue plasminogen activator (rtPA);   Device: Solitaire FR
Sponsor:   Covidien
Completed - verified February 2015

Brain P-gp and Inflammation in People With Epilepsy

Condition:   Epilepsies, Partial
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2015

A Healthy Volunteer Study to Investigate the Blood Concentrations, the Effect on Blood Clotting and the Safety of Multiple Doses of DPOC-4088 Tablets in Different Doses.

Conditions:   Deep Vein Thrombosis Leg;   Stroke (in Patients With Atrial Fibrillation)
Interventions:   Drug: DPOC-4088;   Drug: Placebo
Sponsors:   Diakron Pharmaceuticals;   Drug Research Unit Ghent, Ghent, Belgium;   Kinesis Pharma BV, Breda, the Netherlands
Terminated - verified July 2012

AAV2-GDNF for Advanced Parkinson s Disease

Condition:   Parkinson's Disease
Intervention:   Genetic: Convection enhanced delivery/AAV2-GDNF
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2015

Impact of Renal SympAthetic DenerVation on Chronic HypErtension

Condition:   Uncontrolled Hypertension
Intervention:   Device: Celcius Thermacool Catheter or Chilli II Cooled Ablation Catheter
Sponsor:   Vivek Reddy
Recruiting - verified February 2015

A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Brilinta

Condition:   Acute Coronary Syndromes
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified February 2015

Cardiovascular Outcomes Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects With Cardiovascular Risk Factors (The Light Study)

Conditions:   Obesity;   Overweight
Interventions:   Drug: NB32;   Drug: PBO;   Behavioral: Weight Management Program
Sponsor:   Takeda
Active, not recruiting - verified February 2015

Xarelto [SPAF-QOL] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban (Xarelto_ BAY59-7939)
Sponsor:   Bayer
Recruiting - verified February 2015

Xarelto [SPAF] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban(Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified February 2015

Ponatinib - Frontline for Chronic Myeloid Leukemia (CML) in Accelerated Phase (AP)

Condition:   Leukemia
Intervention:   Drug: Ponatinib
Sponsors:   M.D. Anderson Cancer Center;   Ariad Pharmaceuticals
Recruiting - verified February 2015

Tailored Antiplatelet Therapy Versus Recommended Dose of Prasugrel

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Modification of Prasugrel based on a biological assay;   Drug: prasugrel / clopidogrel;   Device: Verify Now
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Eli Lilly and Company;   Daiichi Sankyo Inc.;   Allies in Cardiovascular Trials Initiatives and Organized Networks:ACTION;   Accumetrics, Inc.;   Stentys
Recruiting - verified February 2015

Effectiveness of Intensive Aphasia Therapy Under Routine Clinical Conditions

Conditions:   Aphasia;   Stroke
Interventions:   Behavioral: Intensive integrative aphasia therapy;   Behavioral: Waiting list control group
Sponsors:   University Hospital Muenster;   Fresenius University of Applied Sciences, Dept. of Health and Social Sciences, Hamburg and Idstein;   Charite University, Berlin, Germany;   Entwicklungsgruppe Klinische Neuropsychologie, Klinikum Bogenhausen, München;   Institut für Biometrie und Klinische Epidemiologie, Charité Campus Benjamin Franklin, Berlin;   RWTH Aachen University;   Bundesverband für die Rehabilitation der Aphasiker e.V.;   Tagesklinik für kognitive Neurologie, Universitätsklinikum Leipzig;   MEDIAN Klinik Grünheide;   Brandenburgklinik Berlin-Brandenburg GmbH;   St. Mauritius Therapieklinik;   Aphasie- und Seniorenzentrum Josef Bergmann Vechta;   Behandlungs- und Rehabilitationszentrum für Intensiv-Therapie Lindlar;   Wickerklinik Bad Homburg v.d.H.;   Asklepios Neurologische Klinik Falkenstein;   Akademische Praxis für Sprachtherapie / Praxis für Rehabilitationswesen Aschaffenburg;   Städtisches Klinikum München, Klinikum Bogenhausen;   Schoen Clinic Bad Aibling;   m&i-Fachklinik Bad Liebenstein;   m&i-Fachklinik Enzensberg;   m&i-Fachklinik Herzogenaurach;   mediclin Klinikum Soltau;   Moritz Klinik, Bad Klosterlausnitz;   Klinikum Christophsbad, Göppingen
Completed - verified February 2015

The Childhood and Adolescent Migraine Prevention Study

Conditions:   Migraine;   Migraine Disorders;   Headache
Interventions:   Drug: Amitriptyline;   Drug: Topiramate;   Drug: Placebo
Sponsors:   Children's Hospital Medical Center, Cincinnati;   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified February 2015

Spinal Cord Injury Leg Rehabilitation

Conditions:   Spinal Cord Injury;   Paraplegia;   Quadriplegia;   Tetraplegia
Intervention:   Device: AMES Treatment
Sponsors:   Oregon Health and Science University;   Shepherd Center, Atlanta GA;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2015

Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Spasticity in the Leg After a Stroke

Condition:   Post-stroke Spasticity of the Lower Limb.
Interventions:   Drug: IncobotulinumtoxinA (400 Units);   Drug: Placebo Comparator
Sponsor:   Merz Pharmaceuticals GmbH
Active, not recruiting - verified February 2015

Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device (LVAD) and Medical Management

Condition:   Heart Failure
Interventions:   Device: HM II (HeartMate II LVAD);   Drug: OMM (Optimal Medical Management)
Sponsor:   Thoratec Corporation
Active, not recruiting - verified February 2015

Iloprost Therapy in Patients With Critical Limb Ischemia

Condition:   Peripheral Arterial Disease
Intervention:   Drug: Iloprost (Ilomedin, BAYQ6256)
Sponsor:   Bayer
Completed - verified February 2015

Rate Ventricular Control Therapy in Patients With Permanent Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Device: implantable continuous monitor
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Recruiting - verified February 2015

Impact of INsulin Sensitivity on Cardiovascular Risk Markers During 10-20 Years of FOllow up

Conditions:   Diabetes Mellitus;   Hypertension;   Ischemic Heart Disease;   Stroke
Intervention:  
Sponsor:   Oslo University Hospital
Active, not recruiting - verified February 2015

Management of New-Onset Postoperative Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Coronary Artery Disease;   Post Operative Arrythmia
Intervention:  
Sponsors:   Emory University;   Medtronic
Recruiting - verified February 2015

The PERFusion Use in Stroke Evaluation Study

Condition:   Ischemic Stroke
Intervention:   Other: Computed tomography perfusion imaging
Sponsors:   California Pacific Medical Center Research Institute;   California Pacific Medical Center
Recruiting - verified February 2015

Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia

Condition:   Cardiac Arrest
Interventions:   Drug: amiodarone;   Drug: Lidocaine;   Other: Normal saline
Sponsors:   University of Washington;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research  (CIHR);   Heart and Stroke Foundation of Canada;   American Heart Association;   Defence Research and Development Canada;   U.S. Army Medical Research and Materiel Command
Recruiting - verified February 2015

Manganese-Enhanced Magnetic Resonance Imaging in Healthy Volunteers and People With Multiple Sclerosis

Conditions:   Multiple Sclerosis;   Optic Neuritis
Intervention:   Drug: Mangafodipir (Teslascan)
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 2014

Treat Stroke to Target

Conditions:   Ischemic Stroke;   Transient Ischemic Attack;   Atherosclerotic Stenosis
Interventions:   Procedure: Target : 100 mg/dL (+/-10 mg/dL);   Procedure: 70 mg/dL
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Pfizer;   AstraZeneca;   Merck Sharp & Dohme Corp.
Recruiting - verified December 2013

CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: linagliptin;   Drug: glimepiride;   Drug: linagliptin placebo;   Drug: glimepride placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting - verified February 2015

Quantitative Imaging and Proton Spectroscopy in Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:   Other: Magnetic Resonance Imaging
Sponsors:   New York University School of Medicine;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2015

Neural Dynamics and Connectivity in Response Inhibition and Traumatic Brain Injury

Conditions:   Traumatic Brain Injury;   Stroke;   Headache;   PTSD
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Department of Defense;   Center for Neuroscience and Regenerative Medicine (CNRM);   National Institutes of Health Clinical Center (CC)
Recruiting - verified January 2015

Rehabilitation of Cognitive Changes in Breast Cancer Survivors

Condition:   Breast Cancer
Intervention:   Behavioral: Cogmed Working Memory Training Program
Sponsors:   Memorial Sloan Kettering Cancer Center.;   MARTELL FOUNDATION
Active, not recruiting - verified February 2015

A Clinical Trial to Evaluate the HeartWare® Ventricular Assist System

Condition:   Chronic Heart Failure
Interventions:   Device: HeartWare® VAS;   Device: Control LVAD
Sponsor:   HeartWare, Inc.
Active, not recruiting - verified October 2014

Atrial Fibrillation Registry for Ankle-brachial Index Prevalence Assessment: Collaborative Italian Study.

Conditions:   Atrial Fibrillation;   Peripheral Vascular Disease
Intervention:  
Sponsor:   University of Roma La Sapienza
Completed - verified February 2015

Anticoagulation in Stent Intervention

Conditions:   Atrial Fibrillation;   Stroke
Interventions:   Drug: Acetylsalicylic Acid + clopidogrel + acenocoumarol;   Drug: Acetylsalicylic Acid  + clopidogrel
Sponsor:   Hospital Universitari Vall d'Hebron Research Institute
Active, not recruiting - verified February 2015

State Of The Art Functional Imaging In Sickle Cell Disease

Condition:   Sickle Cell Anemia
Intervention:  
Sponsor:   St. Jude Children's Research Hospital
Recruiting - verified February 2015

BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME).

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: BI 10773 low dose;   Drug: Placebo BI 10773 high dose;   Drug: BI 10773 high dose;   Drug: Placebo BI 10773 low dose;   Drug: Placebo BI 10773 low dose;   Drug: Placebo BI 10773 high dose
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting - verified February 2015

Study of Subthalamic Brain Stimulation in Parkinson Disease (PD)

Condition:   Parkinson Disease
Intervention:   Device: Implantable pulse generator (deep brain stimulator)
Sponsors:   University of Alabama at Birmingham;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2015

Neural Prostheses and Gait Performance: Model-Based Strategies

Condition:   Hemiplegia
Intervention:   Device: EMS 2000
Sponsor:   Department of Veterans Affairs
Recruiting - verified February 2015

Sitagliptin Cardiovascular Outcome Study (MK-0431-082)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Sitagliptin phosphate;   Drug: Placebo
Sponsors:   Merck Sharp & Dohme Corp.;   Duke Clinical Research Institute, Oxford Diabetes Trials Unit
Active, not recruiting - verified February 2015

A Study of All-Cause Mortality and Cardiovascular Morbidity in CKD Patients on Dialysis and Those Not on Renal Replacement Therapy Receiving Mircera or Reference ESAs.

Condition:   Anemia
Interventions:   Drug: ESAs (darbepoetin alfa, epoetin alfa or epoetin beta);   Drug: methoxy polyethylene glycol-epoetin beta [Mircera];   Drug: methoxy polyethylene glycol-epoetin beta [Mircera]
Sponsor:   Hoffmann-La Roche
Active, not recruiting - verified February 2015

Blood Markers of Inflammation, Blood Clotting and Blood Vessel Function in HIV-infected Adults

Condition:   HIV
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2015

Nutrition Intervention Trials in Linxian Follow-up Study

Conditions:   Esophageal Cancer;   Gastric Cancer
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting - verified February 2015

Brain Function in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis

Condition:   Cerebral Cortex Dysfunction
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified January 2015

Anemia in Heart Failure With a Preserved Ejection Fraction (HFPEF)

Condition:   Anemia
Interventions:   Drug: Erythropoietin alpha;   Drug: Placebo
Sponsors:   Mathew S. Maurer;   National Institute on Aging (NIA)
Completed - verified February 2015

Study of Late-Occurring Complications in Childhood Cancer Survivors

Conditions:   Cancer Survivor;   Cardiovascular Complications;   Hematopoietic/Lymphoid Cancer;   Unspecified Childhood Solid Tumor, Protocol Specific
Interventions:   Other: questionnaire administration;   Other: laboratory biomarker analysis
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Recruiting - verified February 2015

Diagnosis of Pheochromocytoma

Condition:   Pheochromocytoma
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified February 2015

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