Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Modulating Interaction of Motor Learning Networks in Rehabilitation of Stroke

Conditions:   Stroke;   Stroke, Chronic;   Stroke, Middle Cerebral Artery With Infarction
Interventions:   Device: Active continuous theta burst stimulation (cTBS);   Device: Placebo (Sham) continuous theta burst stimulation;   Behavioral: Motor Practice
Sponsor:   University of Michigan
Recruiting - verified March 2017

Wearable Device for Motivating Hand Use After Stroke

Condition:   Cerebral Stroke
Intervention:   Device: Manumeter
Sponsor:   University of California, Irvine
Not yet recruiting - verified March 2017

Clinical and Economic Outcomes of Oral Anticoagulants in Non-valvular Atrial Fibrillation

Condition:   Non-Valvular Atrial Fibrillation
Intervention:  
Sponsor:   Bristol-Myers Squibb
Active, not recruiting - verified March 2017

A Prospective Cohort Study of Perioperative Covert Stroke and Postoperative Cognitive Dysfunction

Conditions:   Anesthesia;   Postoperative Cognitive Dysfunction;   Covert Stroke
Intervention:  
Sponsor:   Beijing Tiantan Hospital
Not yet recruiting - verified March 2017

Immersive Virtual Reality Based Training for Rehabilitation of Subacute Stroke

Condition:   Immersion Virtual Reality Training ,Stroke, Upper Extremity, Randomized Controlled Trial
Interventions:   Other: immersion virtual reality (VR)-based rehabilitation;   Other: traditional rehabilitation training
Sponsor:   Second Affiliated Hospital of Wenzhou Medical University
Not yet recruiting - verified March 2017

Intraarterial Stem Cells in Subacute Ischemic Stroke

Conditions:   Ischemic Stroke;   MCA Infarction
Interventions:   Biological: autologous BMMNC stem cells;   Other: standard care
Sponsor:   Postgraduate Institute of Medical Education and Research
Completed - verified March 2017

Shuxuetong for Prevention of Recurrence in Acute Cerebrovascular Events With Embolism

Condition:   Embolic Stroke
Interventions:   Drug: Shuxuetong Injection;   Drug: Placebo Injection
Sponsor:   Ministry of Science and Technology of the People´s Republic of China
Not yet recruiting - verified March 2017

China Registry of Non-disabling Ischemic Cerebrovascular Events

Conditions:   Transient Ischemic Attack;   Minor Stroke
Intervention:   Other: observational only- no intervention
Sponsors:   The First Affiliated Hospital of Zhengzhou University;   National Health and Family Planning Commission, P.R.China;   Beijing Tiantan Hospital
Not yet recruiting - verified March 2017

A Pilot Study of Edoxaban in Patients With Non-Valvular Atrial Fibrillation and Left Atrial Appendage Closure

Conditions:   Non-Valvular Atrial Fibrillation;   Left Atrial Appendage Closure
Interventions:   Drug: Edoxaban;   Device: WATCHMAN LAA Closure;   Drug: Aspirin and Clopidogrel;   Drug: Aspirin and Warfarin
Sponsors:   Scripps Health;   Daiichi Sankyo Inc.
Not yet recruiting - verified March 2017

NATional TUnisian REgistry of Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:  
Sponsors:   Dacima Consulting;   Société Tunisienne de Cardiologie & de Chirurgie Cardio-Vasculaire
Recruiting - verified March 2017

Mobile Cardiovascular Risk Service Trial

Conditions:   Cardiovascular Diseases;   Personal Health Records;   Pharmaceutical Care;   Mobile Apps
Interventions:   Other: Pharmacist-led cardiovascular risk service (CVRS);   Other: Mobile access to study Personal Health Record;   Other: Web access to study Personal Health Record
Sponsor:   University of Iowa
Not yet recruiting - verified October 2016

Computer Simulated Atrial Fibrillation Tool

Condition:   Atrial Fibrillation
Intervention:   Other: Virtual Platform
Sponsors:   Nova Scotia Health Authority;   Cardiac Arrhythmia Network of Canada
Not yet recruiting - verified March 2017

Long-term Evaluation Protocol (12 Months Postoperative) of Total Knee Prostheses Anatomic With Resurfaced Patella Versus Non-resurfaced Patella in Patients Requiring Total Knee Arthroplasty

Condition:   Arthroplasty
Interventions:   Other: Patellar resurfacing;   Other: Patellar non-resurfacing
Sponsor:   Hospices Civils de Lyon
Recruiting - verified March 2017

Examining the Effects of Three Soft Tissue Treatments on Functional Movement and Functional Performance Enhancement

Condition:   Functional Performance
Interventions:   Device: Astym;   Device: Stick;   Device: Massage
Sponsors:   Rocky Mountain University of Health Professions;   Performance Dynamics;   Indiana Athletic Trainers' Association
Completed - verified March 2017

Chongqing Intracerebral Hemorrhage Study

Conditions:   Intracerebral Hemorrhage;   Stroke;   Hematoma
Intervention:  
Sponsor:   First Affiliated Hospital of Chongqing Medical University
Recruiting - verified March 2017

Observation of Principal Hemodynamic Variables After Spinal Anesthesia With Non Invasive Hemodynamic Monitoring

Conditions:   Hemodynamics;   Fluid Therapy;   Anesthesia, Spinal;   Monitoring, Intraoperative
Intervention:  
Sponsor:   Istituto Ortopedico Rizzoli
Completed - verified March 2017

Beijing Hospital Atherosclerosis Study

Conditions:   Atherosclerosis;   Cardiovascular Diseases;   Coronary Artery Disease;   Myocardial Ischemia;   Stroke
Intervention:  
Sponsor:   Beijing Hospital
Recruiting - verified March 2017

Physiological Effects of Lung Recruitment During General Anesthesia and Low-tidal Volume Ventilation

Conditions:   Anesthesia, General;   Surgery
Interventions:   Drug: Fluid resuscitation or amine administration;   Drug: General anesthetic;   Drug: Fluid administration;   Procedure: Low-tidal volume ventilation;   Procedure: Scheduled recruiting maneuvers
Sponsor:   Catholic University of the Sacred Heart
Recruiting - verified March 2017

Electroacupuncture for Poststroke Patients With Shoulder Pain

Conditions:   Stroke;   Shoulder Pain;   Stroke, Complication;   Cerebral Infarction;   Cerebral Hemorrhage
Interventions:   Device: electroacupuncture;   Device: sham electroacupuncture
Sponsors:   Kyunghee University;   Wonkwang University Gwangju Medical Center;   National Rehabilitation Center, Seoul, Korea
Not yet recruiting - verified March 2017

Endovascular Therapy for Renal Artery Stenosis in China

Conditions:   Renal Artery Obstruction;   Hypertension, Renovascular
Intervention:   Procedure: Endovascular Therapy
Sponsor:   Chinese Academy of Medical Sciences, Fuwai Hospital
Not yet recruiting - verified March 2017

Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function

Condition:   Cerebral Small Vessel Diseases
Interventions:   Drug: Amlodipine;   Drug: Losartan;   Drug: Atenolol
Sponsors:   Ludwig-Maximilians - University of Munich;   University of Edinburgh;   Maastricht University Medical Center;   UMC Utrecht;   University of Oxford
Not yet recruiting - verified March 2017

Ticagrelor Versus High-dose Clopidogrel in Patients With High Platelet Reactivity on Clopidogrel After PCI

Condition:   Coronary Artery Disease
Interventions:   Drug: Ticagrelor;   Drug: Clopidogrel
Sponsor:   Nanjing First Hospital, Nanjing Medical University
Not yet recruiting - verified March 2017

Low-dose of Ticagrelor and Double Standard-dose Clopidogrel on Platelet Aggregation in Clopidogrel Resistance's Patients With Coronary Heart Disease

Conditions:   Coronary Artery Disease;   Clopidogrel, Poor Metabolism of
Interventions:   Drug: Clopidogrel;   Drug: ticagrelor
Sponsor:   First Affiliated Hospital of Harbin Medical University
Recruiting - verified February 2017

Evaluation of Selected Disorders With Sleep Bruxism

Conditions:   Sleep Bruxism;   Hypertension;   Thyroid Dysfunction;   Mental Status Change;   Sleep Apnea;   Sleep Disorders;   Cardiovascular Risk Factor;   Cardiovascular Diseases;   Temporomandibular Disorder
Interventions:   Drug: Clonidine;   Drug: Buspirone
Sponsor:   Wroclaw Medical University
Not yet recruiting - verified March 2017

Functional Connectivity as a Biomarker of rTMS

Condition:   Traumatic Brain Injury
Intervention:   Device: rTMS
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 21, 2017

Goal-Directed Fluid Therapy for Patients Undergoing Oro-Maxillofacial Surgery

Condition:   Blood Pressure, Low
Intervention:  
Sponsor:   Kaohsiung Medical University Chung-Ho Memorial Hospital
Enrolling by invitation - verified August 2016

High-resolution MRI of Inflammation in the Intracranial Arterial Vessel Wall

Condition:   Stroke
Intervention:   Drug: Ferumoxytol Injectable Product
Sponsors:   University of Utah;   AMAG Pharmaceuticals, Inc.
Not yet recruiting - verified March 2017

Study on the Clinical Efficacy of Chinese Medicine Treatment of Sequelae of Apoplexy

Condition:   Stroke
Intervention:   Combination Product: Chinese medicine treatment
Sponsor:   Tongsheng Su
Enrolling by invitation - verified January 2017

Effects of Virtual Reality Based Rehabilitation in Acute Stroke Patients in an Inpatient Rehab Setting

Conditions:   Stroke Syndrome;   Hemiplegia
Intervention:   Device: Rapael
Sponsor:   Montefiore Medical Center
Not yet recruiting - verified March 2017

Clinical and Physiological Studies of Tremor Syndromes

Conditions:   Parkinson Disease;   Dystonia;   Essential Tremor
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 16, 2017

A Study to Evaluate the Safety and Effectiveness of the Left Atrial Appendage Closure Therapy Using BSJ003W

Condition:   Atrial Fibrillation Non-Rheumatic
Intervention:   Device: BSJ003W
Sponsor:   Boston Scientific Japan K.K.
Recruiting - verified March 2017

Electric Field Navigated 1hz Rtms for Post-stroke Motor Recovery Trial

Condition:   Ischemic Stroke
Interventions:   Device: Nexstim NBS guided active rTMS;   Device: Nexstim NBS guided sham rTMS
Sponsor:   Nexstim Ltd
Recruiting - verified March 2017

Comparing Effects of Various Combinations of 6 Hertz(Hz) rTMS & LFrTMS on Motor Recovery Due to Cerebrovascular Disease

Condition:   Cerebrovascular Disease
Interventions:   Device: real LFrTMS at unaffected M1;   Device: real primed LFrTMS at unaffected M1;   Device: combined rTMS at both M1;   Device: all sham stimulation
Sponsor:   Beijing Hospital
Recruiting - verified March 2017

Study of Allogeneic Umbilical Cord Blood Infusion for Adults With Ischemic Stroke

Conditions:   Stroke;   Stroke, Acute;   Brain Injury, Acute
Interventions:   Biological: Umbilical Cord Blood;   Other: Placebo
Sponsors:   Joanne Kurtzberg, MD;   The Marcus Foundation;   Emory University;   M.D. Anderson Cancer Center
Recruiting - verified March 2017

Characterization of Myocardial Interstitial Fibrosis and Cardiomyocyte Hypertrophy by Cardiac MRI in Heart Failure

Condition:   Heart Failure
Interventions:   Other: Stretching exercises;   Other: Aerobic exercise in treadmill;   Other: Local strengthening exercises
Sponsor:   University of Campinas, Brazil
Not yet recruiting - verified March 2017

Comparison of Left Atrial Appendage Occlusion vs Standard Medical Therapy in Patients in AF Undergoing TAVI

Conditions:   Atrial Fibrillation;   Aortic Stenosis
Intervention:   Device: LAAO
Sponsors:   University of Zurich;   St. Jude Medical
Recruiting - verified March 2017

Opportunistic Screening in Pharmacies for Atrial Fibrillation in Seniors (>65 Years)

Condition:   Incidence of Atrial Fibrillation in Adults Aged ≥ 65
Intervention:  
Sponsors:   RWTH Aachen University;   Apothekerverband Aachen e.V.;   Pfizer
Active, not recruiting - verified March 2017

Noninvasive Pulse Contour Analysis for Hemodynamic Assessment in Patients With Chronic Heart Failure

Condition:   Heart Failure
Interventions:   Device: Noninvasive pulse contour analysis;   Device: Pulmonary artery catheterization
Sponsor:   Heart and Diabetes Center North-Rhine Westfalia
Completed - verified March 2017

Family Planning and HIV in Postpartum Women in Mbarara

Condition:   HIV and Family Planning
Intervention:   Behavioral: Family Planning Support
Sponsors:   Mbarara University of Science and Technology;   National Institutes of Health (NIH);   NIH Office of AIDS Research (OAR);   National Institute of Mental Health (NIMH);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2017

Impact of Left Atrial Appendage Closure on Physical Capacity.

Condition:   Atrial Fibrillation
Intervention:  
Sponsors:   University of Leipzig;   University of Jena
Recruiting - verified March 2017

Identification, Electro-mechanical Characterisation and Ablation of Driver Regions in Persistent Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Other: Novel mapping algorithm
Sponsor:   Barts & The London NHS Trust
Recruiting - verified March 2017

Validation Study of SCALA, Scale for Lateropulsion

Condition:   Stroke
Intervention:   Device: SCALA
Sponsor:   University Hospital, Grenoble
Not yet recruiting - verified March 2017

A Study to Evaluate the Safety and Efficacy of Basmisanil in Adults With Severe Motor Impairment Following an Ischemic Stroke

Condition:   Stroke
Interventions:   Drug: Basmisanil;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Recruiting - verified March 2017

Deep Brain Stimulation Surgery for Focal Hand Dystonia

Conditions:   Dystonia;   Focal Dystonia;   Musician's Dystonia
Intervention:   Procedure: DBS surgery
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified February 23, 2017

Assessment of a Physio-neuro Platform (SynPhNe) for Home-based Retraining of Hand Function in Stroke Survivors

Conditions:   Stroke;   Hemiparesis
Interventions:   Device: SynPhNe platform;   Other: Conventional therapy
Sponsor:   Spaulding Rehabilitation Hospital
Not yet recruiting - verified March 2017

Prevention of Non-Surgical Bleeding by Management of HeartMate II Patients Without Antiplatelet Therapy

Condition:   Heart Failure
Interventions:   Device: HeartMate II (HMII);   Drug: Warfarin;   Drug: acetylsalicylic acid (ASA) therapy
Sponsor:   St. Jude Medical
Recruiting - verified March 2017

Clinical Trial to Assess the Efficacy and to Evaluate Safety of HT047 in Patients With Acute Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: HT047 High-dose group;   Drug: HT047 Low-dose group;   Drug: Placebo
Sponsor:   Hocheol Kim
Recruiting - verified March 2017

Preventing Epilepsy Using Vigabatrin In Infants With Tuberous Sclerosis Complex

Condition:   Tuberous Sclerosis Complex
Interventions:   Drug: Vigabatrin;   Drug: Placebo
Sponsors:   Martina Bebin;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2017

Confounding Factors in the Detection of Intracranial Hemorrhage With the Infrascanner

Conditions:   Ischemic Stroke;   Brain Tumor;   Brain Surgery;   Intracranial Hemorrhage;   Headache;   Head Trauma
Intervention:   Device: Infrascanner
Sponsor:   Ziekenhuis Oost-Limburg
Completed - verified March 2017

Proadrenomedullin for Early Risk Assessment in the Emergency Department

Condition:   Fatal Outcome
Intervention:  
Sponsor:   University of Athens
Completed - verified March 2017

Multiple Treatment Session Study to Assess GSK2398852 Administered Following and Along With GSK2315698

Condition:   Amyloidosis
Interventions:   Drug: GSK2315698 (CPHPC);   Biological: GSK2398852 (anti-SAP mAb)
Sponsor:   GlaxoSmithKline
Not yet recruiting - verified March 2017

Observational Study to Evaluate Safety of Idarucizumab in Pediatric Patients

Conditions:   Uncontrolled Hemorrhage;   Emergency Procedures
Intervention:   Drug: idarucizumab
Sponsor:   Boehringer Ingelheim
Not yet recruiting - verified March 2017

Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

Condition:   Multiple Sclerosis
Interventions:   Drug: Methylprednisolone;   Drug: Methylprednisolone
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified February 16, 2017

A Study to Evaluate the Efficacy and Safety of TF0023 Spray on Subjects With Ischemic Strokes

Condition:   Ischemic Stroke
Intervention:   Drug: TF0023
Sponsor:   Techfields Inc
Recruiting - verified November 2016

Prediction of Brain Injury in Premature Infants

Conditions:   Intraventricular Hemorrhage;   Periventricular Leukomalacia;   Brain Injury;   Extreme Prematurity
Intervention:   Other: Brain Monitoring Platform
Sponsors:   Baylor College of Medicine;   Texas Children's Hospital;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2017

Cerebral Autoregulation in Patients With Epilepsy

Condition:   Epilepsy
Intervention:  
Sponsor:   Yi Yang
Recruiting - verified March 2017

Patient Convenience Study- NIS RELATE

Condition:   Atrial Fibrillation
Interventions:   Drug: Pradaxa (dabigatran);   Drug: Vitamin K antagonist
Sponsor:   Boehringer Ingelheim
Recruiting - verified March 2017

Xarelto on Prevention of Stroke and Non-central Nervous System Systemic Embolism in Patients With Non-valvular Atrial Fibrillation in China: A Non-interventional Study

Condition:   Stroke
Intervention:   Drug: Rivaroxaban (Xarelto, BAY 59-7939)
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting - verified March 2017

An Extension Study to Assess Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)

Condition:   Duchenne Muscular Dystrophy
Interventions:   Drug: Vamorolone 0.25 mg/day/day;   Drug: Vamorolone 0.75 mg/day/day;   Drug: Vamorolone 2.0 mg/day/day;   Drug: Vamorolone 6.0 mg/day/day
Sponsors:   ReveraGen BioPharma, Inc.;   University of Pittsburgh;   National Institute of Neurological Disorders and Stroke (NINDS);   Cooperative International Neuromuscular Research Group;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified March 2017

A Study to Assess Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)

Condition:   Duchenne Muscular Dystrophy
Interventions:   Drug: Vamorolone 0.25 mg/kg/day;   Drug: Vamorolone 0.75 mg/kg/day;   Drug: Vamorolone 2.0 mg/kg/day;   Drug: Vamorolone 6.0 mg/kg/day
Sponsors:   ReveraGen BioPharma, Inc.;   University of Pittsburgh;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS);   National Institute of Neurological Disorders and Stroke (NINDS);   Cooperative International Neuromuscular Research Group
Recruiting - verified March 2017

CT COMPARE: CT COronary Angiography to Measure PlAque REduction

Condition:   Cardiovascular Disease
Interventions:   Drug: Rosuvastatin;   Drug: Atorvastatin
Sponsor:   National Institutes of Health Clinical Center (CC)
Recruiting - verified February 23, 2017

Low Dose RT to Reduce Cerebral Amyloidosis in Early Alzheimer's

Condition:   Alzheimer's Disease
Interventions:   Radiation: 10 GY in 5 daily fractions;   Radiation: 20 GY in 10 daily fractions
Sponsor:   Virginia Commonwealth University
Recruiting - verified March 2017

Thoraflex™ Hybrid IDE Study

Conditions:   Aortic Aneurysm;   Aortic Dissection;   Aortic Rupture
Intervention:   Device: Thoraflex™ Hybrid Device
Sponsors:   Terumo CVS;   Vascutek Ltd.
Recruiting - verified March 2017

Carotid Arteries Stenting Complications: Transradial Approach Versus Transfemoral

Conditions:   Carotid Atherosclerosis;   Carotid Stenosis;   Ischemic Attack;   Stroke;   Bleeding
Interventions:   Procedure: Transradial carotid artery stenting;   Procedure: Transfemoral carotid artery stenting
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Completed - verified March 2017

Get With the Guidelines-Stroke Registry

Condition:   Stroke
Intervention:   Other: GWTG Stroke program
Sponsor:   American Heart Association
Recruiting - verified March 2017

The Stroke and Exercise Program

Conditions:   Stroke;   Exercise;   Sedentary Lifestyle;   Ischemic Attack, Transient
Interventions:   Behavioral: mHealth-Enhance Physical Activity Intervention;   Other: Physical Activity Intervention
Sponsor:   The Miriam Hospital
Recruiting - verified September 2016

Traumatic Brain Injury Biological Diagnosis Via High Definition Tractography Asymmetry Screening

Condition:   Traumatic Brain Injury
Intervention:   Procedure: MRI of the Brain (No Contrast) Scan
Sponsor:   New York University School of Medicine
Recruiting - verified March 2017

Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy With Ex Vivo Generated Polyomavirus-Specific T-Cells

Condition:   Leukoencephalopathy
Interventions:   Biological: PyVST;   Other: No Intervention
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 13, 2017

A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Recruiting - verified March 2017

ShenFu Injection for Myocardial Protection in Patients With Acute ST Segment Elevation Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Drug: Shenfu Injection;   Drug: 5% Glucose Injection
Sponsors:   Beijing Anzhen Hospital;   China Resources Sanjiu Medical & Pharmaceutical Co., Ltd.
Recruiting - verified March 2017

Cholinergic Receptor Imaging in Dystonia

Conditions:   Cervical Dystonia;   Dystonia;   Movement Disorder;   Focal Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 13, 2017

Impact of Anesthesia Type on Outcome in Patients With Acute Ischemic Stroke (AIS) Undergoing Endovascular Treatment

Condition:   Acute Stroke
Interventions:   Other: Intravenous anesthetics;   Other: local anesthesia;   Other: Controlled ventilation;   Other: Spontaneous breathing
Sponsor:   Beijing Tiantan Hospital
Recruiting - verified March 2017

Physical Activity Maintenance in Stroke

Condition:   Stroke
Interventions:   Behavioral: Brochure and Telephone Support;   Behavioral: Brochure
Sponsor:   McMaster University
Completed - verified March 2017

Safety and Efficacy of Post Ablation Apixaban Use for Reduction of the Risk of Cerebrovascular Events in Patients Undergoing Ventricular Tachycardia Radiofrequency Catheter Ablation

Condition:   Ventricular Tachycardia
Interventions:   Drug: Apixaban;   Drug: Aspirin
Sponsors:   Dhanunjaya Lakkireddy, MD, FACC;   Bristol-Myers Squibb
Recruiting - verified March 2017

Study to Evaluate the Treatment Effect of PT003 on Cardiovascular Hemodynamics in Subjects With Moderate to Severe COPD

Condition:   COPD
Interventions:   Drug: GFF MDI (PT003);   Drug: Placebo MDI
Sponsor:   Pearl Therapeutics, Inc.
Recruiting - verified March 2017

Tumor Related Epilepsy

Conditions:   Epilepsy;   Cancer;   Brain Neoplasm
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 14, 2017

Effectiveness of Virtual Reality Gaming Therapy Versus CI Therapy for Upper Extremity Rehabilitation

Conditions:   Stroke;   Hemiparesis
Interventions:   Behavioral: Traditional CI Therapy;   Behavioral: Gaming CI Therapy;   Behavioral: Gaming CI Therapy with Additional Contact via Video Conference;   Behavioral: Traditional Occupational Therapy/Physical Therapy
Sponsors:   Ohio State University;   OhioHealth;   Providence Medford Medical Center;   University of Alabama at Birmingham
Recruiting - verified March 2017

The Effect of Ticagrelor on 15-Epi-Lipoxin A4 and Inflammation

Condition:   Atherosclerosis
Interventions:   Drug: Clopidogrel;   Drug: Ticagrelor
Sponsor:   Baylor College of Medicine
Recruiting - verified March 2017

Patient Convenience Study (RE-SONANCE)

Conditions:   Atrial Fibrillation;   Stroke
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified March 2017

Natural History of Rett Syndrome & Related Disorders

Conditions:   Rett Syndrome;   MECP2 Duplication dIsorder;   RTT-related Conditions
Intervention:  
Sponsors:   University of Alabama at Birmingham;   National Institutes of Health (NIH);   National Center for Advancing Translational Science (NCATS);   Rare Diseases Clinical Research Network;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2017

Evaluation of a Tele-Rehabilitation Service Program

Conditions:   Stroke;   Paresis
Intervention:   Device: Tele-motion rehabilitation system
Sponsors:   Mayo Clinic;   The Gertner Institute;   ReAbility Online
Not yet recruiting - verified March 2017

Efficacy and Safety of 3 Doses of S47445 Versus Placebo in Patients With Alzheimer's Disease at Mild to Moderate Stages With Depressive Symptoms

Condition:   Alzheimer's Disease
Interventions:   Drug: S47445 5mg;   Drug: S47445 15mg;   Drug: S47445 50mg;   Drug: Placebo
Sponsor:   Institut de Recherches Internationales Servier
Active, not recruiting - verified March 2017

Implantable Cardiac Monitors in High-Risk Post-Infarction Patients With Cardiac Autonomic Dysfunction

Conditions:   Myocardial Infarction;   Autonomic Nervous System Diseases
Intervention:   Device: Medtronic Reveal LINQ implantable cardiac monitor
Sponsors:   Klinikum der Universitaet Muenchen;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK);   Medtronic Bakken Research Center
Recruiting - verified March 2017

Sitagliptin Effects on Arterial Vasculature and Inflammation in Obesity

Conditions:   Atherosclerosis;   Inflammation
Interventions:   Drug: Sitagliptin;   Drug: Placebo
Sponsor:   University of Southern California
Recruiting - verified March 2017

The Peregrine Post-Market Study for the Treatment of Hypertension

Condition:   Hypertension
Intervention:   Device: Peregrine System Infusion Catheter
Sponsor:   Ablative Solutions, Inc.
Recruiting - verified March 2017

Special Drug Use Investigation of Xarelto for Venous Thromboembolism (VTE)

Condition:   Venous Thromboembolism
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting - verified March 2017

Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa II

Conditions:   Sickle Cell Disease;   Stroke
Interventions:   Drug: Hydroxyurea (Moderate Dose);   Drug: Hydroxyurea (Low Dose)
Sponsors:   Vanderbilt University Medical Center;   Aminu Kano Teaching Hospital;   Murtala Muhammed Specialist Hospital;   National Institute of Neurological Disorders and Stroke (NINDS);   Barau Dikko Teaching Hospital/Kaduna State University
Recruiting - verified March 2017

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified March 2017

Epidemiological Study on the Safety of Aspirin in The Health Improvement Network (THIN)

Conditions:   Secondary Prevention;   Stroke;   Ischemic Heart Disease;   Coronary Heart Disease
Interventions:   Drug: Acetylsalicylic Acid (Asprin, BAYE4465);   Drug: Clopidogrel, Oral Anticoagulants, NSAIDs and SSRIs
Sponsor:   Bayer
Recruiting - verified March 2017

Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection

Conditions:   HIV Infections;   Neurologic Disorders
Intervention:   Drug: Anakinra
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Johns Hopkins University
Enrolling by invitation - verified March 16, 2017

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified March 2017

Platelet Reactivity in Acute Non-disabling Cerebrovascular Events

Conditions:   Stroke;   Ischemic Attack, Transient
Interventions:   Drug: Ticagrelor and Acetylsalicylic acid;   Drug: Clopidogrel and Acetylsalicylic acid
Sponsors:   Ministry of Science and Technology of the People´s Republic of China;   Beijing Municipal Science & Technology Commission
Recruiting - verified March 2017

aMAZE Study: LAA Ligation Adjunctive to PVI for Persistent or Longstanding Persistent Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Device: LARIAT + PVI;   Device: Pulmonary Vein Isolation
Sponsor:   SentreHEART, Inc.
Recruiting - verified March 2017

Propensity to Develop Plasticity in the Parieto- and Cerebello-Motor Networks in Dystonia From the Perspective of Abnormal High-Order Motor Processing

Conditions:   Writer's Cramp;   Healthly Volunteers;   Cervical Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 1, 2017

In Vivo Characterization of Inflammation With Ferumoxytol, an Ultrasmall Superparamagnetic Iron Oxide Nanoparticle, on 7 Tesla Magnetic Resonance Imaging

Condition:   Multiple Sclerosis
Intervention:   Drug: Ferumoxytol
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified March 6, 2017

Safety and Efficacy Study of Lotus Valve for Transcatheter Aortic Valve Replacement (REPRISE Japan)

Condition:   Aortic Stenosis
Intervention:   Device: Lotus Valve System
Sponsor:   Boston Scientific Corporation
Active, not recruiting - verified March 2017

Effect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus
Interventions:   Biological: Albiglutide 30 mg;   Biological: Albiglutide 50 mg;   Biological: Albiglutide matching placebo
Sponsors:   GlaxoSmithKline;   Duke Clinical Research Institute
Active, not recruiting - verified March 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting - verified March 2017

HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)

Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Drug: Darunavir;   Drug: Ritonavir;   Drug: Raltegravir;   Drug: Zidovudine
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified February 1, 2017

Oral Guanabenz for Multiple Sclerosis

Conditions:   Multiple Sclerosis, Relapsing-Remitting;   Multiple Sclerosis
Intervention:   Drug: Guanabenz
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 14, 2017

Post-Market Clinical Follow-Up Study to Confirm Clinical Performance and Safety of the Codman Enterprise® 2 Vascular Reconstruction Device in the Endovascular Treatment of Intracranial Aneurysms

Condition:   Intracranial Aneurysm
Intervention:   Device: Enterprise 2 Vascular Reconstruction Device
Sponsor:   Codman & Shurtleff
Recruiting - verified March 2017

Prospective Evaluation of Carotid Free-floating Thrombus

Conditions:   Stroke;   Transient Ischemic Attack
Intervention:   Radiation: Computed Tomographic Angiogram
Sponsors:   Ottawa Hospital Research Institute;   The Ottawa Hospital
Recruiting - verified March 2017

Open-Label Extension and Safety Study for Patients With Crohn's Disease Previously Enrolled in the Etrolizumab Phase III Study GA29144

Condition:   Crohn Disease
Intervention:   Drug: etrolizumab
Sponsor:   Hoffmann-La Roche
Recruiting - verified March 2017

Influence on Plasticity of Brain Temperature

Condition:   Healthly Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 9, 2017

Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects

Condition:   Familial Frontotemporal Dementia
Intervention:  
Sponsors:   Mayo Clinic;   National Institute on Aging (NIA);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2017

Using Virtual Counselors to Overcome Genetic Literacy Barriers

Conditions:   Heart Disease;   Stroke;   Diabetes;   Cancer
Interventions:   Behavioral: VICKY;   Behavioral: MFHP
Sponsors:   Boston University;   Northeastern University
Enrolling by invitation - verified March 2017

Effect Of Early C-PAP Treatment For Sleep Apnea On Rehabilitation Of Stroke Patients

Conditions:   Sleep Apnea;   Stroke
Interventions:   Device: Watchpat;   Device: CPAP
Sponsor:   Soroka University Medical Center
Not yet recruiting - verified March 2017

Effects of a Positive Slope Treadmill Training in Individuals After Stroke. (Hemislope)

Condition:   Stroke
Intervention:   Other: Inclined treadmill training
Sponsor:   Centre d'Investigation Clinique et Technologique 805
Completed - verified March 2017

Weight Loss Referral for Healthier Survivorship in Obese Stage I-II Endometrial Cancer Survivors or Atypical Hyperplasia

Conditions:   Complex Endometrial Hyperplasia With Atypia;   Stage IA Uterine Corpus Cancer;   Stage IB Uterine Corpus Cancer;   Stage II Uterine Corpus Cancer
Interventions:   Behavioral: Weight Loss Specialist;   Other: Quality-of-Life Assessment;   Other: Medical Chart Review
Sponsors:   Case Comprehensive Cancer Center;   National Cancer Institute (NCI)
Active, not recruiting - verified March 2017

Structural and Functional Brain Changes in Response to Post-Stroke Rehabilitation

Condition:   Cerebrovascular Accident
Intervention:   Other: upper limb rehabilitation for chronic stroke
Sponsor:   Louis Stokes VA Medical Center
Active, not recruiting - verified March 2017

Comparison of Electrophysiologic and Ultrasound Guidance for Onabotulinum Toxin A Injections in Focal Upper Extremity Dystonia and Spasticity

Conditions:   Dystonia;   Focal Dystonia;   Musician's Dystonia;   Muscle Spasticity
Interventions:   Procedure: BoNT injection;   Procedure: US guidance;   Procedure: E-stim Guidance
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 8, 2017

Kyoto Congestive Heart Failure Study

Conditions:   Congestive Heart Failure;   Heart Failure, Diastolic;   Heart Failure, Systolic;   Elderly Frail;   Guideline Adherence
Intervention:   Other: Standard
Sponsor:   Kyoto University, Graduate School of Medicine
Recruiting - verified March 2017

Virtual Reality Exercise for Stroke Rehabilitation in Inpatients Who Are Unable to Stand

Condition:   Stroke
Interventions:   Other: virtual reality training;   Other: control
Sponsors:   Bruyere Research Institute;   Ottawa Hospital Research Institute;   University of Ottawa;   Heart and Stroke Foundation of Canada
Active, not recruiting - verified March 2017

Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability

Conditions:   Chronic Troublesome Sialorrhea;   Cerebral Palsy;   Stroke;   Traumatic Brain Injury;   Intellectual Disability
Interventions:   Drug: IncobotulinumtoxinA;   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Recruiting - verified March 2017

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified March 2017

Drug Persistence/Adherence in Patients Treated With Dabigatran or VKA for Stroke Prevention in Non Valvular Atrial Fibrillation (SPAF)

Condition:   Atrial Fibrillation
Interventions:   Drug: Dabigatran etexilate;   Drug: Phenprocoumon
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified March 2017

Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

Conditions:   Stroke;   Secondary Prevention
Interventions:   Drug: optional ASA as comedication;   Drug: placebo to ASA;   Drug: placebo to optional ASA as comedication;   Drug: placebo to dabigatran etexilate;   Drug: ASA 100 mg;   Drug: dabigatran etexilate
Sponsor:   Boehringer Ingelheim
Recruiting - verified March 2017

Safety Evaluation of 3K3A-APC in Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Biological: 3K3A-APC;   Drug: Placebo
Sponsors:   ZZ Biotech, LLC;   National Institute of Neurological Disorders and Stroke (NINDS);   Cedars-Sinai Medical Center;   Massachusetts General Hospital;   University of Iowa
Recruiting - verified March 2017

Implementation of Comprehensive Stroke Rehabilitation Therapy for Enhanced Quality of Life

Condition:   Stroke
Interventions:   Other: Experimental Group, Sub-Acute;   Other: Experimental Group, Chronic;   Other: Standard of Care, Sub-Acute;   Other: Standard of Care, Chronic
Sponsor:   University of Florida
Recruiting - verified March 2017

Safety and Efficacy Study of Lotus Valve for Transcatheter Aortic Valve Replacement

Condition:   Aortic Stenosis
Interventions:   Device: Lotus Valve System;   Device: CoreValve Transcatheter Aortic Valve Replacement System;   Device: LOTUS Edge Valve System
Sponsor:   Boston Scientific Corporation
Suspended - verified March 2017

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease, on Dialysis

Condition:   Anemia
Interventions:   Drug: Roxadustat;   Drug: Epoetin alfa
Sponsors:   AstraZeneca;   FibroGen
Recruiting - verified March 2017

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease (CKD), Not on Dialysis

Condition:   Anemia
Interventions:   Drug: Roxadustat;   Drug: Placebo
Sponsors:   AstraZeneca;   FibroGen
Recruiting - verified March 2017

Neural Basis of Decision-Making Deficits in Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Uniformed Services University of the Health Sciences
Recruiting - verified March 2, 2017

Mediterranean Diet and Protein-Sparing Modified Diet for Metabolic Syndrome in Liver Transplant Recipients

Conditions:   Liver Transplantation;   Metabolic Syndrome X;   Obesity
Interventions:   Other: Control group;   Other: Mediterranean diet;   Other: Protein-Sparing Modified Fast (PSMF)
Sponsor:   The Cleveland Clinic
Terminated - verified July 2014

A Phase 3 Clinical Outcomes Study to Compare the Incidence of Major Adverse Cardiovascular Events in Subjects Presenting With Acute Coronary Syndrome Treated With Losmapimod Compared to Placebo (LATITUDE-TIMI 60)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Losmapimod 7.5 mg twice daily;   Drug: Placebo twice daily;   Drug: Standard therapy
Sponsors:   GlaxoSmithKline;   The TIMI Study Group
Completed - verified March 2017

Study of Hepatic Function in Patients With Spinal and Bulbar Muscular Atrophy

Conditions:   Liver;   Motor Neuron Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 3, 2017

A Blinded Study to Evaluate Effect on Atrial Fibrillation Burden in Patients With Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Interventions:   Drug: BMS-919373;   Drug: Placebo (Matching with BMS-919373)
Sponsor:   Bristol-Myers Squibb
Completed - verified June 2016

Deep Brain Stimulation Therapy in Movement Disorders

Conditions:   Parkinson's Disease;   Movement Disorders;   Deep Brain Stimulation;   Dystonia;   Essential Tremor
Intervention:   Other: Deep Brain Stimulation Management
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 9, 2017

Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders

Conditions:   Amyotrophic Lateral Sclerosis (ALS);   Myasthenia Gravis;   Myopathies;   Stroke;   Parkinson's Disease
Intervention:  
Sponsor:   Beth Israel Deaconess Medical Center
Recruiting - verified March 2017

Neurocognitive Robot-assisted Rehabilitation of Hand Function After Stroke

Conditions:   Stroke;   Upper Extremity Paresis
Interventions:   Device: robot-assisted neurocognitive therapy of hand function;   Other: Conventional neurocognitive rehabilitation
Sponsor:   Roger Gassert
Active, not recruiting - verified March 2017

Innovative Ultrasound Technology in Neuromuscular Disease

Conditions:   Amyotrophic Lateral Sclerosis;   Muscular Dystrophy;   Radiculopathy;   Myopathy;   Polyneuropathy and Mononeuropathies
Intervention:  
Sponsors:   Beth Israel Deaconess Medical Center;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2017

Prospective, Randomized Trial of Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome (ACS)
Interventions:   Drug: Ticagrelor;   Drug: Prasugrel
Sponsors:   Deutsches Herzzentrum Muenchen;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)
Recruiting - verified March 2017

Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation

Conditions:   Amyotrophic Lateral Sclerosis;   Frontotemporal Lobar Degeneration
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Aging (NIA)
Recruiting - verified March 16, 2017

Electrical Impedance Myography: Exploratory Studies in Healthy People and People With Neuromuscular Disorders

Conditions:   Neuromuscular Disease;   Motor Neuron Disease;   Inherited Neuromuscular Conditions;   Inherited Neuropathies
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 16, 2017

Cerebrospinal Fluid Collection and Repository Storage

Condition:   Neurological Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 15, 2017

Discharge Educational Strategies for Reduction of Vascular Events

Conditions:   Intracerebral Infarcts;   Ischemic Stroke;   Hemorrhagic Strokes;   TIA's
Intervention:   Behavioral: DESERVE education
Sponsors:   New York University School of Medicine;   Columbia University;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2017

Skeletal Muscle Biomarkers in People With Fragile Sarcolemmal Muscular Dystrophy

Condition:   Genetic Disorder
Intervention:  
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institutes of Health Clinical Center (CC);   University of Massachusetts, Worcester
Recruiting - verified December 15, 2016

Sickle Cell Disease - Stroke Prevention in Nigeria Trial

Conditions:   Sickle Cell Anemia;   Sickle Cell Disease;   Stroke
Intervention:   Drug: Hydroxyurea
Sponsors:   Vanderbilt University Medical Center;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   Aminu Kano Teaching Hospital
Active, not recruiting - verified March 2017

Proof of Concept (POC) in Patients With Ischaemic Stroke

Condition:   Cerebrovascular Accident
Interventions:   Drug: GSK249320 100/mg;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Terminated - verified March 2017

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention &Amp; Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute;   Janssen Research & Development, LLC
Recruiting - verified March 2017

VITamin D and OmegA-3 TriaL: Effects on Bone Structure and Architecture

Conditions:   Bone Density;   Body Composition;   Bone Health
Interventions:   Dietary Supplement: Vitamin D3 placebo;   Dietary Supplement: Fish oil placebo;   Drug: omega-3 fatty acids (fish oil);   Dietary Supplement: Vitamin D3
Sponsors:   Brigham and Women's Hospital;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Active, not recruiting - verified March 2017

Circadian Rhythms and Sleep-Wake Cycles in Parkinson's Disease

Condition:   Parkinson's Disease
Intervention:   Other: Light exposure
Sponsors:   Massachusetts General Hospital;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2017

Multicenter Trial to Evaluate the Effect of Dapagliflozin on the Incidence of Cardiovascular Events

Conditions:   Diabetes Mellitus, Non-Insulin-Dependent;   High Risk for Cardiovascular Event
Interventions:   Drug: Dapagliflozin 10 mg;   Drug: Placebo tablet
Sponsors:   AstraZeneca;   Bristol-Myers Squibb;   The TIMI Study Group;   Hadassah Medical Organization
Active, not recruiting - verified January 2017

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)

Condition:   Progressive Multifocal Leukoencephalopathy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 13, 2017

Vitamin D and Omega-3 Fatty Acids (VITAL Trial): Effects on Fractures

Condition:   Fractures
Interventions:   Dietary Supplement: Vitamin D3 placebo;   Dietary Supplement: Fish oil placebo;   Drug: omega-3 fatty acids (fish oil);   Dietary Supplement: Vitamin D3
Sponsors:   Brigham and Women's Hospital;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Active, not recruiting - verified March 2017

Evaluation of the Phased Radio Frequency Ablation System

Condition:   Persistent Atrial Fibrillation
Intervention:   Device: Medtronic Phased RF Ablation System
Sponsor:   Medtronic Atrial Fibrillation Solutions
Terminated - verified March 2017

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified March 2017

Brain P-gp and Inflammation in People With Epilepsy

Condition:   Epilepsies, Partial
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 3, 2017

Assessment of Patients With Suspected Coronary Artery Disease (CAD): What is the Best Initial Imaging Strategy?

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   Harald Becher;   Alberta Health Services;   University of Alberta
Completed - verified March 2017

Non-invasive Neurostimulation in Parkinson's Disease

Condition:   Parkinson's Disease
Interventions:   Procedure: low-intensity transcranial electrical stimulation;   Procedure: transcranial ultrasound
Sponsors:   Spaulding Rehabilitation Hospital;   National Institute of Neurological Disorders and Stroke (NINDS);   Highland Instruments, Inc.
Recruiting - verified March 2017

Use of Repetitive Facilitative Exercise Program in Established Stroke

Condition:   Stroke
Intervention:   Other: Occupational therapy- Repetitive Facilitative Exercise
Sponsor:   Mayo Clinic
Terminated - verified March 2017

Genetic and Physical Study of Childhood Nerve and Muscle Disorders

Conditions:   Muscular Dystrophies;   Muscle Myopathies;   Hereditary Spastic Paraplegias;   Inherited Neuropathies;   Inherited Neuromuscular Conditions
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 16, 2017

Botulinum Toxin for Pelvic Pain in Women With Endometriosis

Conditions:   Endometriosis;   Botulinum Toxin A;   Chronic Pelvic Pain;   Pelvic Muscle Spasms;   Quality of Life
Intervention:   Drug: Botuninum toxin A
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified November 4, 2016

Coronary Hybrid Revascularisation Study

Condition:   Significant Coronary Artery Disease
Intervention:   Procedure: Combined CABG and PCI
Sponsor:   Aarhus University Hospital Skejby
Active, not recruiting - verified March 2017

Analysis of Visual-Motor Task Electrophysiological Activity During Deep Brain Stimulation for Treatment-Resistant Movement Disorders

Condition:   Obsessive-Complusive Disorder
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   George Washington University
Recruiting - verified March 16, 2017

Step Monitoring to Improve ARTERial Health

Conditions:   Type 2 Diabetes;   Hypertension
Interventions:   Behavioral: Step count prescription;   Behavioral: Usual care
Sponsors:   McGill University Health Center;   Canadian Institutes of Health Research (CIHR)
Completed - verified March 2017

GLORIA-AF Registry Program - Second and Third Phases

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified March 2017

Intensive Blood Pressure and LDL Lowering in Diabetic Patients With Coronary Artery Disease

Conditions:   Type 2 Diabetes;   Coronary Artery Disease;   Hypertension;   Dyslipidemia
Interventions:   Other: intensive control;   Other: standard control
Sponsors:   Takeshi Morimoto;   University of the Ryukyus
Recruiting - verified March 2017

Bazedoxifene Post Approval Safety Study (PASS) in the European Union (EU)

Condition:   Osteoporosis, Postmenopausal
Interventions:   Drug: Bazedoxifene;   Drug: Bisphosphonate;   Drug: Raloxifene
Sponsor:   Pfizer
Active, not recruiting - verified March 2017

PRX-00023 Therapy in Localization-Related Epilepsy

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Partial Epilepsy
Intervention:   Drug: PRX-00023
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 27, 2017

Silk Road Medical First in Man Study - Neuroprotection During Carotid Stenting and Angioplasty

Condition:   Carotid Artery Diseases
Intervention:   Device: Carotid angioplasty and stenting with Silk Road Embolic Protection System
Sponsor:   Silk Road Medical
Completed - verified March 2017

Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression

Conditions:   Atherosclerosis;   Hypercholesterolemia
Interventions:   Drug: Statin Drugs;   Other: HMG-CoA Reductase Inhibitors
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed - verified February 22, 2017

Evaluation, Pathogenesis, and Outcome of Subjects With or Suspected Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Center for Neuroscience and Regenerative Medicine (CNRM);   United States Department of Defense;   Henry M. Jackson Foundation for the Advancement of Military Medicine
Recruiting - verified February 17, 2017

Evaluation of Routine Follow-up Coronary Angiography After Percutaneous Coronary Intervention Trial

Condition:   Coronary Artery Disease
Interventions:   Procedure: follow-up coronary angiography;   Procedure: Clinical follow-up
Sponsor:   Takeshi Morimoto
Completed - verified March 2017

Double Blind Study of Hypertonic Saline vs Mannitol in the Management of Increased Intracranial Pressure (ICP).

Condition:   Elevated Intracranial Pressure
Interventions:   Drug: hypertonic saline;   Drug: Mannitol
Sponsor:   Beth Israel Deaconess Medical Center
Withdrawn - verified March 2017

Screening Protocol for Patients With Stroke

Condition:   Stroke
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 16, 2017

Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes of PHACE Syndrome

Condition:   PHACE Syndrome
Intervention:  
Sponsor:   Medical College of Wisconsin
Completed - verified March 2017

The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Darapladib 160 mg;   Drug: Placebo;   Other: Standard Therapy
Sponsors:   GlaxoSmithKline;   The TIMI Study Group
Completed - verified March 2017

Live Kidney Donor Study - Cross-Sectional and Historical Cohort Study

Conditions:   End Stage Renal Disease;   Transplantation
Intervention:  
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   National Heart, Lung, and Blood Institute (NHLBI);   Health Resources and Services Administration (HRSA)
Completed - verified March 2017

Investigation of Neurofeedback With Real-Time fMRI in Healthy Volunteers and Patients With Hyperkinetic Movement Disorders

Conditions:   Movement Disorder;   Tourette Syndrome;   Healthy Volunteer
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 10, 2017

World Maternal Antifibrinolytic Trial

Condition:   Postpartum Haemorrhage
Interventions:   Drug: Tranexamic acid;   Drug: Placebo [Saline]
Sponsor:   London School of Hygiene and Tropical Medicine
Active, not recruiting - verified March 2017

The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial

Condition:   Atherosclerosis
Interventions:   Drug: Darapladib;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Completed - verified March 2017

Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System

Conditions:   Central Nervous System Disease;   Multiple Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 14, 2017

Fondaparinux Trial With Unfractionated Heparin (UFH) During Revascularization in Acute Coronary Syndromes (ACS)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: fondaparinux background and standard dose UFH;   Drug: Fondaparinux background and low dose heparin;   Drug: Open label fondaparinux
Sponsor:   GlaxoSmithKline
Completed - verified March 2017

Biomarkers of Risk of Parkinson Disease

Conditions:   Parkinson Disease;   Autonomic Nervous System Diseases;   Pure Autonomic Failure
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified February 9, 2017

tDCS and Physical Therapy in Stroke

Condition:   Cerebrovascular Accident
Interventions:   Device: Active transcranial Direct Current Stimulation / Constraint Induced Movement Therapy;   Device: Sham transcranial Direct Current Stimulation / Constraint Induced Movement Therapy
Sponsor:   Beth Israel Deaconess Medical Center
Completed - verified March 2017

Cardiac Stem Cell Infusion in Patients With Ischemic CardiOmyopathy (SCIPIO)

Conditions:   Coronary Artery Disease;   Congestive Heart Failure
Intervention:   Biological: Treatment group
Sponsors:   University of Louisville;   Brigham and Women's Hospital;   Jewish Hospital and St. Mary's Healthcare
Completed - verified March 2017

Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System

Condition:   Healthy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 16, 2017

RECORD: Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Rosiglitazone;   Drug: Sulfonylurea;   Drug: Metformin
Sponsor:   GlaxoSmithKline
Completed - verified March 2017

Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

Condition:   HTLV-1
Intervention:   Drug: Hu MiK-Beta-1
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 14, 2017

Vision Testing in Patients With Partial Seizures Receiving Either Lyrica or Placebo

Condition:   Epilepsies, Partial
Interventions:   Drug: Lyrica (pregabalin);   Drug: placebo
Sponsor:   Pfizer
Recruiting - verified March 2017

Movement-Related Brain Networks Involved in Hand Dystonia

Conditions:   Movement Disorder;   Focal Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified March 20, 2017

Training for Diagnosing Neurological Disorders

Condition:   Musculoskeletal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 6, 2017

Diuretics In the Management of Essential Hypertension (DIME) Study

Condition:   Hypertension
Interventions:   Drug: Thiazide diuretics;   Drug: No diuretics
Sponsors:   Kyoto University;   University of the Ryukyus
Completed - verified March 2017

Rosiglitazone Versus a Sulfonylurea On Progression Of Atherosclerosis In Patients With Heart Disease And Type 2 Diabetes

Condition:   Atherosclerosis
Interventions:   Drug: Glipizide;   Drug: rosiglitazone maleate
Sponsor:   GlaxoSmithKline
Completed - verified March 2017

Pelvic Pain in Women With Endometriosis

Conditions:   Endometriosis;   Pelvic Pain;   Healthy;   Tubal Ligation
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified February 14, 2017

Evaluation of Primary Chronic Autonomic Failure

Condition:   Autonomic Nervous System Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 23, 2017

Study of Specimens Obtained During Epilepsy Surgery

Condition:   Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 10, 2017

Phenotype/Genotype Correlations in Movement Disorders

Condition:   Movement Disorder
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 6, 2017

Evaluation and Treatment of Patients With Epilepsy

Condition:   Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2, 2017

Prevention of Cerebral Infarction in Sickle Cell Anemia - Comprehensive Sickle Cell Center

Conditions:   Anemia, Sickle Cell;   Blood Disease;   Cerebrovascular Disorders;   Cerebrovascular Accident
Intervention:  
Sponsors:   University of Southern California;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified March 2017

Evaluation of Patients With HAM/TSP

Conditions:   HTLV-I Infection;   Tropical Spastic Paraparesis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 3, 2017