Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Efficacy Study of Functional Electrical Stimulation Controlled by Electromyographic Signal for the Treatment of Upper Limb in Post-stroke Patients

Condition:   Stroke
Interventions:   Device: MeCFES-assisted upper limb rehabilitation;   Other: Usual Care upper limb rehabilitation
Sponsors:   Fondazione Don Carlo Gnocchi Onlus;   Istituto Di Ricerche Farmacologiche Mario Negri
Completed - verified January 2017

Robotic and Conventional Hand Therapy After Stroke

Condition:   Stroke
Interventions:   Device: Amadeo Hand Robot Device;   Other: Conventional Therapy
Sponsors:   Columbia University;   Medical University Innsbruck;   New York University
Completed - verified January 2017

Respiratory Muscle Training in Stroke Swallowing Disorders

Conditions:   Swallowing Disorder;   Stroke;   Respiratory Muscle Training;   Malnutrition
Interventions:   Device: High intensity IEMT;   Device: Sham IEMT
Sponsors:   Parc de Salut Mar;   Instituto de Salud Carlos III
Not yet recruiting - verified January 2017

Perception of Verticality After Stroke

Conditions:   Sensory Disorder;   Stroke;   Cerebrovascular Disorders
Intervention:   Behavioral: Observational clinical assessment
Sponsor:   Universiteit Antwerpen
Not yet recruiting - verified January 2017

Neurophysiology of Surround Inhibition in the Human Motor Cortex

Condition:   Normal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2017

The Effects of WBV on Muscle Stiffness and Reflex Activity in Stroke.

Condition:   Stroke
Interventions:   Device: control;   Device: Low intensity whole body vibration;   Device: High intensity whole body vibration
Sponsor:   The Hong Kong Polytechnic University
Not yet recruiting - verified January 2017

Assessing Accuracy of Clinical Diagnosis and Lesion Location in Acute Neurological Deficits - How Good Are Neurologists?

Conditions:   Stroke Syndrome;   Stroke Hemorrhagic;   Stroke, Acute;   Strokes Thrombotic;   Emergencies;   Diagnostic Self Evaluation
Intervention:   Other: No study specific interventions
Sponsor:   University Hospital Inselspital, Berne
Not yet recruiting - verified January 2017

Use of Electronic Personal Health Records to Improve Medication Adherence

Conditions:   Atrial Fibrillation;   Medication Adherence
Intervention:   Other: Medication Education
Sponsors:   Parkview Health;   Centers for Medicare and Medicaid Services
Completed - verified January 2017

China REgistry of WATCHMAN

Conditions:   Atrial Fibrillation;   Left Atrial Appendage Closure
Intervention:   Device: left atrial appendage closure device implantation
Sponsors:   Fu Wai Hospital, Beijing, China;   Boston Scientific Corporation
Recruiting - verified January 2017

Valvular Heart Disease Registry Study in Second Affiliated Hospital of ZheJiang University

Condition:   Valvular Heart Disease
Intervention:  
Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University
Not yet recruiting - verified December 2016

The Influence of Rhythm, Cognitive Task and Physical Activity on the Cardiac ANS in Chronic Stroke Patients

Condition:   Unrecognized Condition
Intervention:  
Sponsor:   Clalit Health Services
Not yet recruiting - verified January 2017

Comparing Effects of Various Combinations of 6 Hertz(Hz) rTMS & LFrTMS on Motor Recovery Due to Cerebrovascular Disease

Condition:   Cerebrovascular Disease
Interventions:   Device: real LFrTMS at unaffected M1;   Device: real primed LFrTMS at unaffected M1;   Device: combined rTMS at both M1;   Device: all sham stimulation
Sponsor:   Beijing Hospital
Not yet recruiting - verified January 2017

The Application of Pleth Variability Index in Continuous Monitoring the Volume Status of Intraoperative Patients

Condition:   Hemodynamic Monitoring
Intervention:  
Sponsors:   First Affiliated Hospital, Sun Yat-Sen University;   Guangzhou Panyu Central Hospital
Active, not recruiting - verified December 2016

Influence of Age, Weight and Ethnic Background on Blood Pressure

Conditions:   Cardiovascular Diseases;   Vascular Diseases;   Hypertension
Interventions:   Other: Brief lifestyle/medical history questionnaire;   Other: Anthropometric measures;   Other: Blood pressure and arterial stiffness;   Other: Cardiac output and lung function;   Other: Heart rate variability;   Other: Blood sample & spot urine sample;   Other: 24 hour ambulatory blood pressure monitor;   Other: 24 hour urine collection;   Other: Echocardiograph: Left ventricular mass;   Other: Large artery structure: Carotid intima-media thickness;   Other: Small artery structure: Minimum forearm vascular resistance;   Other: Large artery endothelial function;   Other: Small artery endothelial function: Forearm blood flow;   Other: Dundee step test;   Other: Detailed haemodynamic response to submaximal exercise;   Other: Cardiopulmonary fitness: Maximum oxygen consumption;   Other: Haemodynamic response to mental stress
Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   University of Cambridge
Not yet recruiting - verified January 2017

Evaluation of an Active Decision Support System for Hemodynamic Optimization During High Risk Vascular Surgery

Conditions:   Feasibility;   Active Decision Support System;   Goal Directed Therapy
Intervention:   Other: active decision support system
Sponsor:   Medical University of Vienna
Completed - verified January 2017

Registry of the Combination of Antiplatelet Agents and Anticoagulant in Atrial Fibrillation Patients With a CHA2DS2VASc Score >1 Undergoing Percutaneous Coronary Interventions

Condition:   Percutaneous Coronary Intervention
Intervention:   Other: the prevalence of ischemic events
Sponsor:   Assistance Publique Hopitaux De Marseille
Recruiting - verified January 2017

Stanford Healthy Heart Study

Condition:   Obesity
Interventions:   Behavioral: Fun First;   Behavioral: Weight Watchers
Sponsors:   Stanford University;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified January 2017

Fascial Therapy in Elbow Hemophilic Arthropathy

Condition:   Hemophilia
Intervention:   Other: Experimental group
Sponsor:   Real Fundación Victoria Eugenia
Not yet recruiting - verified January 2017

Remote Ischemic Preconditioning for Cardic Surgery

Conditions:   Myocardial Injury;   Remote Ischemic Preconditioning
Interventions:   Procedure: Remote Ischemic Preconditioning;   Procedure: Control
Sponsor:   Xuzhou Medical University
Not yet recruiting - verified January 2017

Annular Contraction for Transcatheter Treatment of Insufficient Mitral ValvE

Conditions:   Mitral Valve Insufficiency;   Cardiac Valve Annuloplasty;   Mitral Valve Annuloplasty;   Cardiovascular Diseases;   Heart Diseases;   Heart Valve Diseases;   Mitral Regurgitation
Intervention:   Device: Cardioband Mitral System
Sponsor:   Valtech Cardio Ltd
Not yet recruiting - verified January 2017

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

Condition:   Mitral Valve Failure
Interventions:   Device: Edwards SAPIEN 3 transcatheter heart valve;   Device: ASHI INTECC Astato XS 20
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified January 2017

Carotid Duplex Ultrasound for Selecting Patients for Endovascular Thrombectomy in Acute Stroke Patients

Condition:   Stroke, Acute
Intervention:   Procedure: After detection of occluded vessels by vascular imaging using carotid duplex ultrasound, digital subtraction angiography is immediately performed before acute endovascular treatment.
Sponsor:   Ryo Itabashi
Recruiting - verified January 2017

Biomarker Effectiveness Analysis in Contrast Nephropathy (BEACON)

Conditions:   Acute Renal Failure;   Kidney Diseases;   Chronic Kidney Disease;   Coronary (Artery); Disease
Intervention:  
Sponsors:   University of Pittsburgh;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   U.S. Department of Veterans Affairs
Active, not recruiting - verified January 2017

Post-Myocardial Infarction Patients in Santa Catarina, Brazil - Catarina Heart Study

Condition:   Myocardial Infarction
Intervention:   Other: Myocardial Infarction
Sponsor:   Instituto de Cardiologia de Santa Catarina
Enrolling by invitation - verified January 2017

Safety and Efficacy of the Symetis ACURATE Neo/TF Compared to the Edwards SAPIEN 3 Bioprosthesis.

Condition:   Aortic Valve Stenosis
Interventions:   Device: Symetis ACURATE neo/TF transfemoral TAVI system;   Device: Edwards Sapien 3 Transcatheter Heart Valve
Sponsors:   University Hospital Inselspital, Berne;   Kerckhoff Heart Center
Not yet recruiting - verified January 2017

Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients

Condition:   Primary Hypertension
Interventions:   Drug: Intensive BP control;   Drug: Standard BP control
Sponsor:   Chinese Academy of Medical Sciences, Fuwai Hospital
Recruiting - verified January 2017

Study of Allogeneic Umbilical Cord Blood Infusion for Adults With Ischemic Stroke

Conditions:   Stroke;   Stroke, Acute;   Brain Injury, Acute
Interventions:   Biological: Umbilical Cord Blood;   Other: Placebo
Sponsors:   Joanne Kurtzberg, MD;   The Marcus Foundation;   Emory University;   M.D. Anderson Cancer Center
Not yet recruiting - verified January 2017

Revive AIS Patients ImmeDiately

Conditions:   Ischemic Stroke;   Occlusion, Cerebrovascular
Intervention:   Device: Revive SE intracranial thrombectomy device
Sponsor:   Changhai Hospital
Recruiting - verified January 2017

Multimodality Monitoring Directed Management of Aneurysmal Subarachnoid Haemorrhage

Condition:   Subarachnoid Hemorrhage, Aneurysmal
Intervention:  
Sponsors:   Adel Helmy;   Cambridge University Hospitals NHS Foundation Trust
Not yet recruiting - verified January 2017

Evaluation of Major Cardiovascular Events in Patients With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo

Conditions:   Cardiovascular Diseases;   Statin Adverse Reaction
Interventions:   Drug: Bempedoic acid 180 mg tablet;   Drug: Matching placebo tablet
Sponsors:   Esperion Therapeutics;   Cleveland Clinic Coordinating Center for Clinical Research (C5 Research)
Recruiting - verified January 2017

The Influence of Exercise on Neuroplasticity and Motor Learning After Stroke

Conditions:   Stroke;   Exercise;   Rest
Interventions:   Behavioral: Exercise;   Behavioral: Practice
Sponsor:   University of British Columbia
Recruiting - verified January 2017

Cytochrome C Oxidase Activity in Newly Diagnosed Glioblastoma Multiforme (GBM)

Condition:   Primary Glioblastoma Multiforme
Intervention:  
Sponsors:   University of Alabama at Birmingham;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2017

The Multitasking Rehabilitation She Enhanced Walking Speed Compared to the Simple Post Stroke Rehabilitation Task (AVC)?

Condition:   Subacute Stroke
Interventions:   Other: rehabilitation multitasking walking.;   Other: Traditional walking rehabilitation
Sponsor:   Centre Hospitalier Universitaire, Amiens
Not yet recruiting - verified January 2017

Apixaban Versus Warfarin in Patients With Left Ventricular Thrombus

Condition:   Left Ventricular Thrombosis
Interventions:   Drug: Apixaban 5 MG Oral Tablet [ELIQUIS];   Drug: Warfarin Sodium
Sponsors:   University of Science Malaysia;   INSTITUT JANTUNG NEGARA
Recruiting - verified January 2017

MET: REevaluation for Perioperative cArdIac Risk (MET-REPAIR)

Condition:   Non Cardiac Surgery
Intervention:  
Sponsor:   European Society of Anaesthesiology
Not yet recruiting - verified January 2017

SmartWATCHes for Detection of Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Device: Five minutes pulse wave recording
Sponsors:   University Hospital, Basel, Switzerland;   University Hospital Greifswald
Recruiting - verified January 2017

Safety and Efficacy of Alteplase When Administered in Chinese Patients With Acute Ischemic Hemispheric Stroke Where Thrombolysis is Initiated Between 3 and 4.5 Hours After Stroke Onset

Condition:   Stroke
Intervention:   Drug: alteplase
Sponsor:   Boehringer Ingelheim
Recruiting - verified January 2017

Clinical Trial of Mild Hypoxia Preconditioning in Patients Undergoing Interventional Treatment

Conditions:   Cerebrovascular Disease;   Mild Hypoxia Preconditioning;   Ischemia, Brain;   Brain Injury, Acute
Interventions:   Procedure: Mild Hypoxia Preconditioning;   Procedure: Sham preconditioning
Sponsor:   Hua Yan
Recruiting - verified January 2017

Telemedical Examination of a Three-Component Oculomotor Testing Battery

Conditions:   Stroke;   Vertigo;   Dizziness
Intervention:   Device: Telemedical video-oculography system
Sponsor:   Munich Municipal Hospital
Completed - verified January 2017

Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI

Condition:   Acute Myocardial Infarction
Interventions:   Drug: LCZ696 (sacubitril/valsartan);   Drug: Ramipril;   Drug: Placebo of LCZ696;   Drug: Placebo of ramipril;   Drug: Valsartan;   Drug: Placebo of valsartan
Sponsor:   Novartis Pharmaceuticals
Recruiting - verified January 2017

Novel Brain Stimulation Therapies in Stroke Guided Expressions of Plasticity

Conditions:   Stroke;   Cerebrovascular Disorders;   Nervous System Diseases;   Brain Diseases;   Cardiovascular Diseases;   Vascular Diseases;   Central Nervous System Diseases
Interventions:   Device: rTMS Contralesional M1;   Device: rTMS Contralesional PMC;   Device: rTMS Ipsilesional PMC;   Device: rTMS sham at Ipsilesional M1
Sponsor:   The Cleveland Clinic
Recruiting - verified January 2017

Women's Heart Attack Research Program: Stress Ancillary Study

Condition:   Myocardial Infarction
Interventions:   Behavioral: Enhanced Usual Care;   Behavioral: Stress Management;   Device: Actigraph
Sponsor:   New York University School of Medicine
Recruiting - verified January 2017

Fully Automated Anesthesia, Analgesia and Fluid Management

Conditions:   General Anesthetic Drug Overdose;   Adverse Effect of Intravenous Anesthetics, Sequela;   Complication of Anesthesia;   Drug Delivery System Malfunction;   Hemodynamic Instability;   Underdosing of Other General Anesthetics
Interventions:   Other: BIS XP, Covidien, Ireland;   Other: EV-1000 TM, Edwards Lifesciences, Irvine, California, USA
Sponsors:   Erasme University Hospital;   Hopital Foch
Completed - verified January 2017

General Anesthesia With ETT vs LMA in Patients Undergoing Ablation for Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Device: General Anesthesia with endotracheal tube;   Device: General Anesthesia with laryngeal mask airway
Sponsor:   Virginia Commonwealth University
Recruiting - verified January 2017

Novel Brain Signal Feedback Paradigm to Enhance Motor Learning After Stroke

Condition:   Stroke
Intervention:   Other: Neural feedback plus FES and motor training
Sponsor:   VA Office of Research and Development
Recruiting - verified January 2017

Evaluating the Therapeutic Effect of Scalp Acupuncture Treatment for Motor Dysfunction in Ischemic Stroke Patients

Conditions:   Ischemic Stroke;   Hemiplegia
Interventions:   Device: Scalp Acupuncture Treatment;   Other: Rehabilitation treatment
Sponsors:   Shanghai University of Traditional Chinese Medicine;   Fudan University
Recruiting - verified January 2017

Long-term Remote Ischemic Preconditioning Improve Long-term Prognosis of Acute Myocardial Infarction Patients Without Emergency Reperfusion Therapy

Condition:   Myocardial Infarction
Intervention:   Other: reported remote ischemic preconditioning (RIPC)
Sponsor:   Xuanwu Hospital, Beijing
Not yet recruiting - verified July 2016

Catheter Ablation and Rate Control of Atrial Fibrillation in Patients With Heart Failure

Conditions:   Catheter Ablation;   Rate Control;   Heart Failure;   Atrial Fibrillation
Intervention:  
Sponsor:   Nanjing Medical University
Completed - verified January 2017

Electrical Stimulation of the Dentate Nucleus for Upper Extremity Hemiparesis Due to Ischemic Stroke

Condition:   Stroke
Intervention:   Device: Deep Brain Stimulation
Sponsor:   Enspire DBS Therapy, Inc.
Recruiting - verified January 2017

Long-term Remote Ischemic Preconditioning Improve the Prognosis of Myocardial Infarction Patients With Emergency Reperfusion Therapy

Condition:   Myocardial Infarction, Acute
Intervention:   Other: remote ischemic preconditioning (RIPC)
Sponsor:   Xuanwu Hospital, Beijing
Not yet recruiting - verified July 2016

Evaluation of the BARD® True™ Flow Valvuloplasty Perfusion Catheter for Aortic Valve Dilatation

Condition:   Aortic Valve Stenosis
Intervention:   Device: True™ Flow Valvuloplasty Perfusion Catheter
Sponsor:   C. R. Bard
Completed - verified January 2017

Patient Education Following a Stroke

Condition:   Stroke
Intervention:   Behavioral: stroke education workshops
Sponsor:   Hopital Foch
Active, not recruiting - verified January 2017

The Metabolism Research of KLK Treating Acute Cerebral Ischemic Stroke: Focus on Drug Frequency-Efficacy Relationship

Condition:   Cerebral Infarction
Intervention:   Drug: Human Urinary Kallidinogenase for Injection
Sponsor:   Huisheng Chen
Recruiting - verified August 2016

Effect of Tadalafil on Cerebral Large Arteries in Stroke

Conditions:   Stroke, Lacunar;   Cerebral Small Vessel Diseases
Interventions:   Drug: Tadalafil;   Drug: Placebo
Sponsor:   Christina Kruuse
Recruiting - verified January 2017

Observational Study to Evaluate Safety of Idarucizumab in Pediatric Patients

Conditions:   Uncontrolled Hemorrhage;   Emergency Procedures
Intervention:   Drug: idarucizumab
Sponsor:   Boehringer Ingelheim
Not yet recruiting - verified January 2017

Mirror Therapy After Stroke: A Dosing Study

Condition:   Stroke
Interventions:   Behavioral: Mirror Box Therapy;   Behavioral: Sham Mirror Box Therapy
Sponsors:   Columbia University;   Helen Hayes Hospital
Recruiting - verified January 2017

Effect of Stroke Neuro-images on Smoking Cessation in Patients With New Stroke.

Conditions:   Stroke;   Smoking Cessation
Interventions:   Behavioral: Neuroimages of stroke;   Behavioral: standardized smoking cessation counseling
Sponsor:   Yale University
Not yet recruiting - verified January 2017

Comparison of Outcomes After Left Atrial Appendage Closure or Oral Anticoagulation in Patients With Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Other: Questionnaire
Sponsor:   University Hospital Inselspital, Berne
Completed - verified January 2017

Audition After a Lesion and in Migraine. (AuditionPostLesion)

Condition:   Migraine Disorders, Brain
Interventions:   Other: Neuropsychological tests;   Other: Neurophysiological tests
Sponsor:   Hospices Civils de Lyon
Recruiting - verified January 2017

Xarelto on Prevention of Stroke and Non-central Nervous System Systemic Embolism in Patients With Non-valvular Atrial Fibrillation in China: A Non-interventional Study

Condition:   Stroke
Intervention:   Drug: Rivaroxaban (Xarelto, BAY 59-7939)
Sponsor:   Bayer
Recruiting - verified January 2017

International Intracranial Dissection Study

Conditions:   Cerebrovascular Disorders;   Vascular: Intracranial;   Intimal Dissection;   Stroke
Intervention:   Other: No study-specific intervention
Sponsors:   University Hospital Inselspital, Berne;   Swiss Heart Foundation;   Cervical Artery Dissections and Ischemic Stroke Patients - Consortium
Recruiting - verified January 2017

An Extension Study to Assess Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)

Condition:   Duchenne Muscular Dystrophy
Interventions:   Drug: Vamorolone 0.25 mg/day/day;   Drug: Vamorolone 0.75 mg/day/day;   Drug: Vamorolone 2.0 mg/day/day;   Drug: Vamorolone 6.0 mg/day/day
Sponsors:   ReveraGen BioPharma, Inc.;   University of Pittsburgh;   National Institute of Neurological Disorders and Stroke (NINDS);   Cooperative International Neuromuscular Research Group;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified January 2017

A Study to Assess Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)

Condition:   Duchenne Muscular Dystrophy
Interventions:   Drug: Vamorolone 0.25 mg/kg/day;   Drug: Vamorolone 0.75 mg/kg/day;   Drug: Vamorolone 2.0 mg/kg/day;   Drug: Vamorolone 6.0 mg/kg/day
Sponsors:   ReveraGen BioPharma, Inc.;   University of Pittsburgh;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS);   National Institute of Neurological Disorders and Stroke (NINDS);   Cooperative International Neuromuscular Research Group
Recruiting - verified January 2017

CT COMPARE: CT COronary Angiography to Measure PlAque REduction

Condition:   Cardiovascular Disease
Interventions:   Drug: Rosuvastatin;   Drug: Atorvastatin
Sponsor:   National Institutes of Health Clinical Center (CC)
Recruiting - verified November 2016

Decision Support for Intraoperative Low Blood Pressure

Condition:   Hypotension
Interventions:   Procedure: Attending real-time decision support;   Procedure: In-room real-time decision support;   Procedure: Attending feedback emails;   Procedure: In-room provider feedback emails;   Device: Anesthesia Information Management System (AIMS);   Device: Perioperative Data Warehouse (PDW);   Procedure: General anesthesia;   Device: Pager system;   Procedure: Central neuraxial anesthesia;   Procedure: Non-cardiac surgery;   Drug: Propofol;   Drug: Sevoflurane;   Drug: Desflurane;   Drug: Isoflurane;   Drug: Ephedrine;   Drug: Phenylephrine;   Drug: Norepinephrine;   Drug: Epinephrine;   Drug: Dobutamine;   Drug: Dopamine;   Drug: Isoproterenol;   Drug: Milrinone;   Drug: Atropine;   Drug: Glycopyrrolate;   Drug: Vasopressin;   Drug: Terlipressin;   Drug: Sodium Chloride 0.9%;   Drug: Ringer's lactate;   Drug: Hydroxyethyl starch solutions;   Drug: Fresh Frozen Plasma;   Drug: Packed Red Blood Cells;   Drug: Albumin solutions;   Drug: Plasma-Lyte;   Drug: Lidocaine;   Drug: Bupivacaine;   Drug: Levobupivacaine;   Drug: Ropivacaine;   Drug: Mepivacaine;   Drug: Tetracaine;   Drug: Prilocaine;   Drug: Procaine;   Drug: Chloroprocaine;   Drug: Benzocaine;   Drug: Articaine
Sponsors:   Vanderbilt University Medical Center;   UMC Utrecht
Recruiting - verified January 2017

A Novel Strategy to Decrease Fall Incidence Post-Stroke

Condition:   Stroke
Intervention:   Behavioral: Backward Walking Training
Sponsor:   VA Office of Research and Development
Not yet recruiting - verified January 2017

Tele-Rehabilitation Study for People With a History of Stroke

Condition:   Stroke
Intervention:   Behavioral: Cognitive Orientation to Occupational Preformance (COOP)
Sponsors:   Baycrest;   Health and Stroke Foundation-Canadian Partnership for Stroke recovery
Active, not recruiting - verified January 2017

Safety and Efficacy Study of a Protease Activated Receptor-4 Antagonist Being Tested to Reduce the Chances of Having Additional Strokes or "Mini Strokes"

Condition:   Thrombosis
Interventions:   Drug: BMS-986141;   Drug: Aspirin;   Other: Placebo
Sponsor:   Bristol-Myers Squibb
Recruiting - verified July 2016

Atrial Fibrillation Registry in Jordan

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Jordan Collaborating Cardiology Group
Recruiting - verified January 2017

Safety and Efficacy of Post Ablation Apixaban Use for Reduction of the Risk of Cerebrovascular Events in Patients Undergoing Ventricular Tachycardia Radiofrequency Catheter Ablation

Condition:   Ventricular Tachycardia
Interventions:   Drug: Apixaban;   Drug: Aspirin
Sponsors:   Dhanunjaya Lakkireddy, MD, FACC;   Bristol-Myers Squibb
Not yet recruiting - verified January 2017

Myalgic Encephalomyelitis Chronic Fatigue at the National Institutes of Health

Condition:   Chronic Fatigue Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified November 2016

Biofeedback to Increase Propulsion During Walking After Stroke

Condition:   Stroke
Interventions:   Procedure: Gait Training with Biofeedback;   Procedure: Gait Training with Verbal Feedback
Sponsor:   VA Office of Research and Development
Recruiting - verified January 2017

Ticagrelor Versus Clopidogrel in Carotid Artery Stenting

Condition:   Carotid Artery Stenosis
Interventions:   Drug: Ticagrelor;   Drug: Clopidogrel;   Drug: Aspirin
Sponsor:   University Hospital, Basel, Switzerland
Recruiting - verified January 2017

Influence of a Multi-parametric Optimization Strategy for General Anesthesia on Postoperative Morbidity and Mortality

Conditions:   Coronary; Ischemic;   Arrhythmias, Cardiac;   Heart Failure;   Peripheral Vascular Diseases;   Dementia;   Stroke;   Pulmonary Disease, Chronic Obstructive;   Respiratory Insufficiency;   Alcoholism;   Cancer;   Diabetes;   Renal Insufficiency
Interventions:   Procedure: OPTI-AGED;   Procedure: Usual Care
Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
Not yet recruiting - verified January 2017

A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Advanced Prostate Cancer and Cardiovascular Disease

Condition:   Prostate Cancer
Interventions:   Drug: Degarelix;   Drug: Leuprolide
Sponsors:   Ferring Pharmaceuticals;   Memorial Sloan Kettering Cancer Center;   Duke Clinical Research Institute
Recruiting - verified January 2017

Sildenafil and Stroke Recovery

Condition:   Stroke
Interventions:   Drug: sildenafil citrate;   Drug: Placebo
Sponsor:   University of Utah
Terminated - verified January 2017

Metabolic Effects of Angiotensin-(1-7)

Conditions:   Obesity;   Insulin Resistance;   Hypertension;   Metabolic Cardiovascular Syndrome
Interventions:   Drug: Angiotensin-(1-7);   Drug: Saline
Sponsor:   Vanderbilt University
Recruiting - verified January 2017

Mechanisms of Ischemic Stroke in Cancer Patients

Conditions:   Stroke;   Cancer
Interventions:   Other: Blood tests;   Other: Transcranial Doppler Microemboli Detection Study
Sponsors:   Weill Medical College of Cornell University;   University of California, Davis;   Memorial Sloan Kettering Cancer Center
Recruiting - verified January 2017

STEPs to Blood Pressure Reduction.

Conditions:   Stroke Prevention;   Blood Pressure Reduction
Interventions:   Behavioral: STEP Clinic;   Behavioral: Usual Care
Sponsor:   The University of Texas Health Science Center, Houston
Recruiting - verified January 2017

Comprehensive Post-Acute Stroke Services

Condition:   Stroke
Intervention:   Other: COMPASS Intervention
Sponsors:   Wake Forest University Health Sciences;   University of North Carolina, Chapel Hill;   Duke University;   East Carolina University
Recruiting - verified January 2017

Open-Label and Single-Arm Study of MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adults

Condition:   Sialorrhea
Intervention:   Drug: MYOBLOC
Sponsor:   US WorldMeds LLC
Active, not recruiting - verified January 2017

High Intensity Interval Training After Stroke

Condition:   Stroke
Interventions:   Behavioral: High intensity interval training;   Behavioral: General information
Sponsor:   Norwegian University of Science and Technology
Recruiting - verified January 2017

Validation of a Purine Biosensor in Detecting Acute Cerebral Ischaemia: Carotid Endarterectomy Model in SMARTChip

Condition:   Stroke
Intervention:  
Sponsors:   University Hospitals Coventry and Warwickshire NHS Trust;   University Hospitals of North Midlands NHS Trust
Recruiting - verified January 2017

Global Study Comparing a rivAroxaban-based Antithrombotic Strategy to an antipLatelet-based Strategy After Transcatheter aortIc vaLve rEplacement to Optimize Clinical Outcomes

Condition:   Transcatheter Aortic Valve Replacement
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Acetylsalicylic acid;   Drug: Clopidogrel
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting - verified January 2017

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified January 2017

Effects of Stimulation Patterns of Deep Brain Stimulation

Conditions:   Parkinson Disease;   Essential Tremor;   Multiple Sclerosis
Interventions:   Procedure: Therapeutic Stimulation Patterns;   Procedure: Symptogenic Stimulation Patterns
Sponsors:   Duke University;   National Institute of Neurological Disorders and Stroke (NINDS);   Emory University;   University of Florida
Enrolling by invitation - verified November 2016

Epidemiological Study on the Safety of Aspirin in The Health Improvement Network (THIN)

Conditions:   Secondary Prevention;   Stroke;   Ischemic Heart Disease;   Coronary Heart Disease
Interventions:   Drug: Acetylsalicylic Acid (Asprin, BAYE4465);   Drug: Clopidogrel, Oral Anticoagulants, NSAIDs and SSRIs
Sponsor:   Bayer
Recruiting - verified January 2017

AdminiStration of Statin On Acute Ischemic stRoke patienT Trial

Condition:   Ischemic Stroke
Intervention:   Drug: Statin
Sponsors:   Hyogo College of Medicine;   Shionogi
Active, not recruiting - verified January 2017

Interest of Direct Aspiration First Pass Technique (ADAPT) for Thrombectomy Revascularisation of Large Vessel Occlusion in Acute Ischaemic Stroke

Condition:   Ischemic Cerebrovascular Accident
Interventions:   Procedure: direct aspiration procedure;   Procedure: stent retriever procedure
Sponsor:   Fondation Ophtalmologique Adolphe de Rothschild
Recruiting - verified December 2016

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified January 2017

Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain

Conditions:   Intractable Pain;   Palliative Care;   Neoplasm Metastasis;   Questionnaires &Amp; Surveys
Intervention:   Drug: Resiniferatoxin
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Suspended - verified October 2016

mHealth Screening to Prevent Strokes

Condition:   Atrial Fibrillation
Interventions:   Device: iRhythm ZIO XT Patch;   Device: Wristband by Amiigo
Sponsors:   Scripps Translational Science Institute;   Janssen Scientific Affairs, LLC;   Aetna, Inc.
Enrolling by invitation - verified January 2017

ARISE: After 8 Hours Reperfusion in Ischemic Stroke Embolization

Condition:   Ischemic Stroke
Intervention:   Device: mechanical thrombectomy
Sponsor:   Abington Memorial Hospital
Recruiting - verified January 2017

aMAZE Study: LAA Ligation Adjunctive to PVI for Persistent or Longstanding Persistent Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Device: LARIAT + PVI;   Device: Pulmonary Vein Isolation
Sponsor:   SentreHEART, Inc.
Recruiting - verified January 2017

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Recruiting - verified January 2017

Southwest Health Extension Partnership to Enhance Research Dissemination

Condition:   Cardiovascular Diseases
Interventions:   Other: Enhanced practice transformation support;   Other: Standard practice transformation support
Sponsors:   University of Colorado, Denver;   University of New Mexico
Recruiting - verified January 2017

Clinical, Pharmacological and Molecular Effects of IV and Oral Acetaminophen in Adults With aSAH

Conditions:   Subarachnoid Hemorrhage;   Stroke
Interventions:   Drug: IV acetaminophen;   Drug: Oral acetaminophen;   Drug: Oral placebo;   Drug: IV placebo
Sponsor:   Milton S. Hershey Medical Center
Recruiting - verified January 2017

Acupuncture for Ischemic Post-stroke Depression

Condition:   Post-stroke Depression
Interventions:   Device: acupuncture;   Drug: placebo;   Device: sham-acupoint acupuncture;   Drug: Fluoxetine
Sponsors:   Menghan Li;   State Administration of Traditional Chinese Medicine of the People's Republic of China
Recruiting - verified January 2017

Characterising Arm Recovery in People With Severe Stroke

Condition:   Stroke
Intervention:   Other: Longitudinal evaluation of recovery
Sponsor:   University of British Columbia
Recruiting - verified January 2017

Aspirin Twice a Day in Patients With Diabetes and Acute Coronary Syndrome

Conditions:   Diabetes Mellitus;   Acute Coronary Syndrome;   Coronary Artery Disease
Interventions:   Drug: Novel strategy Aspirin;   Drug: Conventional strategy Aspirin
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Bayer
Recruiting - verified January 2017

Correlation Analysis Between Brain Lesions and Sensorimotor Impairments in Individuals With Strokes (Preliminary Study)

Condition:   Stroke
Intervention:   Other: MRI
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Recruiting - verified January 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsor:   Bayer
Recruiting - verified January 2017

WATCHMAN Implantation During Hybrid Ablation

Conditions:   Atrial Fibrillation;   Stroke
Intervention:   Device: WATCHMAN Device implantation
Sponsors:   Maastricht University Medical Center;   Boston Scientific Corporation
Completed - verified January 2017

Optimizing Patient's Selection for Endovascular Treatment in Acute Ischemic Stroke

Conditions:   Stroke;   Ischemic Stroke
Intervention:   Device: Mechanical Thrombectomy
Sponsors:   The University of Texas Health Science Center, Houston;   Stryker Neurovascular;   WellStar Health System;   Florida Hospital;   Emory University;   Riverside Methodist Hospital;   Valley Baptist Medical Center;   St. Louis University;   University of Kansas;   Stanford University
Recruiting - verified January 2017

HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)

Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Drug: Darunavir;   Drug: Ritonavir;   Drug: Raltegravir;   Drug: Zidovudine
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified October 2016

Hybrid Versus Catheter Ablation in Persistent AF

Condition:   Atrial Fibrillation
Interventions:   Procedure: Hybrid Ablation;   Procedure: Catheter Ablation
Sponsor:   Maastricht University Medical Center
Recruiting - verified January 2017

Feasibility of Using Prism Adaptation to Treat Spatial Neglect and Motor Function in Stroke

Condition:   Stroke
Intervention:   Behavioral: Prism Adaptation
Sponsor:   Kessler Foundation
Completed - verified January 2017

A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart

Condition:   Acute Coronary Syndromes
Interventions:   Drug: Apixaban;   Drug: vitamin K antagonist;   Drug: Acetylsalicylic acid;   Other: Acetylsalicylic acid placebo
Sponsors:   Bristol-Myers Squibb;   Pfizer;   Duke Clinical Research Institute
Recruiting - verified August 2016

Altering Activation Patterns Post-stroke

Conditions:   Stroke;   Muscle Spasticity;   Hemiparesis
Interventions:   Drug: Cyproheptadine;   Drug: Placebo for Cyproheptadine;   Other: Active Movement Practice (AMP);   Other: Passive Cyclical Stretching
Sponsors:   Rehabilitation Institute of Chicago;   National Institutes of Health (NIH);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified January 2017

Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy

Conditions:   Giant Axonal Neuropathy;   Gene Transfer
Intervention:   Drug: Intrathecal Delivery of scAAV9/JeT-GAN
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2017

Novel Oral Anticoagulants in Stroke Patients

Conditions:   Ischemic Stroke;   Intracranial Hemorrhages
Intervention:  
Sponsors:   University Hospital, Basel, Switzerland;   Swiss Heart Foundation
Recruiting - verified January 2017

Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism (RESCUE)-Japan Registry 2

Condition:   Ischemic Stroke
Intervention:   Procedure: endovascular treatment
Sponsor:   Hyogo College of Medicine
Completed - verified January 2017

Resistive Training Combined With Nutritional Therapy After Stroke

Condition:   Stroke
Interventions:   Other: Protein;   Other: Placebo
Sponsors:   VA Office of Research and Development;   Baltimore VA Medical Center
Recruiting - verified January 2017

Evaluation of the Effectiveness of Eliquis ® (Apixaban) Risk Minimization Tools in European Economic Area (EEA) Countries

Condition:   Stroke, Systemic Embolism, VTEt and VTEp
Intervention:  
Sponsors:   Bristol-Myers Squibb;   Pfizer
Active, not recruiting - verified March 2016

Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)

Condition:   Stroke
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin (Acetylsalicylic acid, BAY1019036);   Other: Rivaroxaban-Placebo;   Other: Aspirin-Placebo
Sponsors:   Bayer;   Janssen, LP;   Hamilton Health Sciences Cooperation, Population Health Research Institute
Recruiting - verified January 2017

Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

Conditions:   Stroke;   Secondary Prevention
Interventions:   Drug: optional ASA as comedication;   Drug: placebo to ASA;   Drug: placebo to optional ASA as comedication;   Drug: placebo to dabigatran etexilate;   Drug: ASA 100 mg;   Drug: dabigatran etexilate
Sponsor:   Boehringer Ingelheim
Recruiting - verified January 2017

Brain Stimulation and Hand Training in Children With Hemiparesis

Condition:   Pediatric Hemiparesis
Interventions:   Device: Transcranial Direct Current Stimulation (tDCS);   Device: Placebo Comparator
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Cerebral Palsy International Research Foundation;   Foundation for Physical Therapy, Inc.;   NIH K01 Career Development Award
Active, not recruiting - verified January 2017

Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI

Conditions:   Cognition Disorder;   Attention Deficit Disorder;   Traumatic Brain Injury
Intervention:   Drug: Methylphenidate
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Suspended - verified October 2016

Healthy Lifestyles After Stroke

Conditions:   Stroke;   Apoplexy;   Cerebral Stroke;   Cerebrovascular Accident;   Cerebrovascular Accident, Acute;   Cerebrovascular Apoplexy;   Cerebrovascular Stroke;   CVA;   Stroke, Acute;   Vascular Accident, Brain
Intervention:   Behavioral: Healthy Lifestyle Training Program
Sponsors:   University of British Columbia;   Canadian Institutes of Health Research (CIHR);   Heart and Stroke Foundation of Canada
Recruiting - verified January 2017

Efficacy of Isradipine in Early Parkinson Disease

Condition:   Parkinson Disease
Interventions:   Drug: Isradipine;   Drug: Placebo (for Isradipine)
Sponsors:   University of Rochester;   National Institute of Neurological Disorders and Stroke (NINDS);   Michael J. Fox Foundation for Parkinson's Research;   The Parkinson Study Group
Active, not recruiting - verified January 2017

Intracerebral Hemorrhage Deferoxamine Trial - iDEF Ttrial

Condition:   Intracerebral Hemorrhage
Interventions:   Drug: Deferoxamine Mesylate;   Drug: Placebo (for Deferoxamine Mesylate)
Sponsors:   Beth Israel Deaconess Medical Center;   Medical University of South Carolina;   National Institute of Neurological Disorders and Stroke (NINDS);   Massachusetts General Hospital;   University of Massachusetts, Worcester;   University of Pennsylvania;   Johns Hopkins University;   Duke University;   University of North Carolina;   University of Florida;   Henry Ford Hospital;   Ohio State University;   St. Joseph's Hospital and Medical Center, Phoenix;   University of California, San Francisco;   Oregon Health and Science University;   Yale New Haven Health System Center for Healthcare Solutions;   University of Iowa;   Hartford Hospital;   The University of Texas Health Science Center, Houston;   Rhode Island Hospital;   Stanford University;   University of Washington;   University of Calgary;   Hopital de l'Enfant-Jesus;   University of Alberta;   Rush University Medical Center;   University Hospitals Cleveland Medical Center;   Columbia University;   Weill Medical College of Cornell University;   New York University Langone Medical Center;   Mount Sinai Hospital, New York;   Loyola University
Recruiting - verified January 2017

Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)

Conditions:   Atrial Fibrillation;   Percutaneous Coronary Intervention
Interventions:   Drug: Dabigatran Etexilate 110mg;   Drug: Warfarin 3mg;   Drug: Aspirin;   Drug: Dabigatran Etexilate 150mg;   Drug: Clopidogrel or Ticagrelor;   Drug: Clopidogrel or Ticagrelor;   Drug: Warfarin 5mg;   Drug: Clopidogrel or Ticagrelor;   Drug: Warfarin 1mg
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified January 2017

An MRI Study of Post-operative Delirium in Patients Undergoing Major Surgery

Condition:   Postoperative Delirium
Intervention:   Procedure: MRI CO2 stress testing
Sponsor:   University of Manitoba
Recruiting - verified January 2017

A Blinded Study to Evaluate Effect on Atrial Fibrillation Burden in Patients With Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Interventions:   Drug: BMS-919373;   Drug: Placebo (Matching with BMS-919373)
Sponsor:   Bristol-Myers Squibb
Completed - verified June 2016

ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea.

Conditions:   Heart Failure;   Obstructive Sleep Apnea;   Central Sleep Apnea
Intervention:   Other: [C11]Acetate and HED PET
Sponsor:   Ottawa Heart Institute Research Corporation
Recruiting - verified January 2017

Multicenter, Prospective, Randomized, Controlled, Double-blind Trial on the Impact of Rosuvastatin on Subclinical Markers of Atherosclerosis in Patients With Primary Necrotizing Vasculitides

Condition:   ANCA-associated Primary Necrotizing Vasculitides
Interventions:   Drug: Rosuvastatin;   Drug: Placebo
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting - verified January 2017

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy;   Device: Carotid stenting
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2017

Efficacy and Safety Study of rTMS for Upper Extremity Motor Function Recovery in Ischemic Stroke Patients

Conditions:   Stroke;   Hemiplegia
Intervention:   Device: Low frequency rTMS
Sponsors:   Seoul National University Bundang Hospital;   DongGuk University;   Seoul National University Hospital
Recruiting - verified January 2017

Adolescent Master Protocol for Participants 18 Years of Age and Older (AMP Up)

Condition:   HIV/AIDS
Intervention:  
Sponsors:   Harvard School of Public Health;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute on Drug Abuse (NIDA);   National Institute of Allergy and Infectious Diseases (NIAID);   NIH Office of AIDS Research (OAR);   National Institute of Mental Health (NIMH);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Deafness and Other Communication Disorders (NIDCD);   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Dental and Craniofacial Research (NIDCR);   National Institute on Alcohol Abuse and Alcoholism (NIAAA);   Tulane University School of Medicine
Recruiting - verified January 2017

Edoxaban vs. Warfarin in Subjects Undergoing Cardioversion of Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Drug: edoxaban;   Drug: Enoxaparin;   Drug: Warfarin
Sponsors:   Daiichi Sankyo Inc.;   Covance;   Quintiles, Inc.
Completed - verified January 2017

Hemodynamic Effects on Cerebral Autoregulation in Acute Stroke

Condition:   Ischemic Stroke
Intervention:  
Sponsors:   Henry Ford Health System;   Wayne State University
Completed - verified January 2017

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Conditions:   Hypertension;   Cardiovascular Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting - verified December 2016

Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency

Conditions:   Metabolic Disease;   Seizures
Interventions:   Drug: SGS-742;   Drug: Placebo
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2017

Efficacy and Safety Study of MYOBLOC® Followed by Open-Label Multiple-Treatment With MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adult Subjects

Condition:   Sialorrhea
Interventions:   Drug: MYOBLOC;   Other: PLACEBO
Sponsor:   US WorldMeds LLC
Active, not recruiting - verified January 2017

Rivaroxaban for the Prevention of Venous Thromboembolism in Asian Patients With Cancer

Conditions:   Rivaroxaban;   Cancer-associated Thrombosis;   Recurrence;   Bleeding
Intervention:   Drug: Rivaroxaban
Sponsors:   Seoul National University Hospital;   Korean Society of Hematology Thrombosis Working Party
Completed - verified January 2017

The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Terminated - verified January 2017

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Terminated - verified January 2017

Mild Versus Moderate Therapeutic Hypothermia in Out-of-hospital Cardiac Arrest Patients

Condition:   Cardiac Arrest
Intervention:   Other: Therapeutic Hypothermia
Sponsor:   Ottawa Heart Institute Research Corporation
Recruiting - verified January 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Germany)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsor:   Bayer
Recruiting - verified January 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxoban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsor:   Bayer
Recruiting - verified January 2017

Neuroplastic Change in Myelin of the Brain

Condition:   Stroke
Intervention:   Behavioral: TRAIT Task
Sponsors:   University of British Columbia;   Canadian Institutes of Health Research (CIHR)
Recruiting - verified January 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)

Condition:   Pulmonary Embolism
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Warfarin
Sponsor:   Bayer
Recruiting - verified January 2017

Tongxinluo Capsule in Ischemic Stroke Patients(TISS)

Condition:   Ischemic Stroke
Interventions:   Drug: Tongxinluo capsule;   Drug: placebo capsule
Sponsor:   yongjun wang
Completed - verified January 2017

Determining Optimal Post-Stroke Exercise (DOSE)

Conditions:   Cerebrovascular Accident;   Stroke;   Cerebral Infarction;   Brain Infarction;   Brain Ischemia;   Cerebrovascular Disorders;   Brain Diseases;   Central Nervous System Diseases;   Nervous System Diseases;   Vascular Diseases
Interventions:   Behavioral: Stroke Management Program (SMP);   Behavioral: Stroke Monitoring Program (SMonP);   Behavioral: Stroke Supplementary Program (SSP)
Sponsor:   University of British Columbia
Recruiting - verified January 2017

Community Level Interventions for Pre-eclampsia

Conditions:   Pre-eclampsia;   Hypertension, Pregnancy Induced
Interventions:   Behavioral: Community Engagement;   Device: PIERS on the Move mHealth decision aid;   Drug: Magnesium Sulfate;   Drug: Methyldopa
Sponsors:   University of British Columbia;   Bill and Melinda Gates Foundation;   Olabisi Onabanjo University;   Centro de Investigacao em Saude de Manhica;   Aga Khan University;   Jawaharlal Nehru Medical College
Recruiting - verified January 2017

Exercise Education for Adults With Seizure Disorders

Conditions:   Seizures;   Epilepsy
Interventions:   Other: Patient Education;   Other: exercise: increase physical activity/goal setting
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 2016

Pediatric Autologous Bone Marrow Mononuclear Cells for Severe Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Interventions:   Biological: autologous bone marrow mononuclear cells;   Other: Placebo Infusion
Sponsors:   The University of Texas Health Science Center, Houston;   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified January 2017

Asymmetrical Gait Training After Pediatric Stroke

Conditions:   Stroke;   Hemiplegia
Interventions:   Behavioral: Conventional physical therapy;   Behavioral: Asymmetrical gait training
Sponsor:   Children's Hospital of Philadelphia
Recruiting - verified January 2017

Lu's Acupuncture and Moxibustion Treatment on Stroke

Conditions:   Ischemic Stroke;   Paralysis
Interventions:   Procedure: Acupuncture;   Procedure: Rehabilitation
Sponsors:   Shanghai University of Traditional Chinese Medicine;   Fudan University
Recruiting - verified January 2017

The Concomitant Cryomaze Procedure Using Nitreous Oxide Cryoprobe: Comparison With Argon Based Cryoprobe

Conditions:   Atrial Fibrillation;   Valve
Interventions:   Device: Cryomaze procedure using Nitrous oxide;   Device: Cryomaze procedure using Argon
Sponsor:   Samsung Medical Center
Completed - verified March 2016

Effects of Transcranial Magnetic Stimulation on Object Recognition

Conditions:   Repetitive TMS (rTMS);   Sham rTMS;   Bilateral rTMS;   Unilateral rTMS
Interventions:   Procedure: Sham rTMS;   Procedure: Bilateral rTMS at same frequency and in phase;   Procedure: Bilateral rTMS at different frequencies;   Procedure: Bilateral rTMSat same frequency and out of phase;   Procedure: rTMS over TP8;   Procedure: rTMS over TP7
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 2016

Remote Rehabilitation Via the Internet in Patients After a Stroke - Physical Rehabilitation Using Biofeedback Systems to Improve Upper Extremity Function

Condition:   Stroke Patients
Interventions:   Device: Hand tutor rehabilitation device;   Device: Arm tutor rehabilitation device
Sponsor:   Sheba Medical Center
Withdrawn - verified January 2017

Mental Practice in Chronic, Stroke Induced Hemiparesis

Condition:   Hemiparesis
Interventions:   Behavioral: Mental Practice Group;   Behavioral: Active Control Group
Sponsor:   Stephen Page
Completed - verified January 2017

Safety and Efficacy of Left Atrial Appendage Occlusion Devices

Condition:   Atrial Fibrillation
Interventions:   Device: LARIAT LAA;   Device: WATCHMAN
Sponsor:   Dhanunjaya Lakkireddy, MD, FACC
Enrolling by invitation - verified January 2017

Ecosystem Focused Therapy in Post Stroke Depression

Conditions:   Depression;   Stroke
Interventions:   Behavioral: Education on Stroke and Depression (ESD);   Behavioral: Ecosystem Focused Therapy (EFT)
Sponsors:   Weill Medical College of Cornell University;   National Institute of Mental Health (NIMH)
Recruiting - verified January 2017

Finding the Optimum Regimen for Duchenne Muscular Dystrophy

Condition:   Duchenne Muscular Dystrophy
Interventions:   Drug: Prednisone;   Drug: Prednisone;   Drug: Deflazacort
Sponsors:   University of Rochester;   Newcastle University;   University Medical Center Freiburg;   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified January 2017

Brain Stimulation-aided Stroke Rehabilitation: Neural Mechanisms of Recovery

Condition:   Stroke
Interventions:   Procedure: tDCS: noninvasive brain stimulation;   Behavioral: Constraint induced movement therapy (CIMT);   Procedure: Sham tDCS: placebo noninvasive brain stimulation
Sponsors:   The Cleveland Clinic;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified January 2017

Tailored Antiplatelet Therapy Versus Recommended Dose of Prasugrel

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Modification of Prasugrel based on a biological assay;   Drug: prasugrel / clopidogrel;   Device: Verify Now
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Eli Lilly and Company;   Daiichi Sankyo Inc.;   Allies in Cardiovascular Trials Initiatives and Organized;   Accumetrics, Inc.;   Stentys
Completed - verified January 2017

Active MOBility Early After Stroke : What Should be the Best Physiotherapy Early After Stroke ?

Condition:   Rehabilitation
Interventions:   Procedure: standard physiotherapy;   Procedure: experimental physiotherapy
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Ministry of Health, France
Completed - verified January 2017

Stroke Self-Management

Condition:   Stroke
Intervention:   Behavioral: Stroke Self-Management
Sponsor:   VA Office of Research and Development
Active, not recruiting - verified January 2017

Fluorescence-guided Surgery for Low- and High-grade Gliomas

Condition:   Glioma
Interventions:   Drug: 5-Aminolevulinic acid (ALA);   Drug: Placebo - ascorbic acid
Sponsor:   St. Joseph's Hospital and Medical Center, Phoenix
Recruiting - verified January 2017

Double Push Acoustic Radiation Force (DP ARF) Ultrasound for Monitoring Degeneration in Duchenne Muscular Dystrophy

Condition:   Muscular Dystrophy, Duchenne
Intervention:  
Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2017

Longitudinal Studies of Brain Structure and Function in MPS Disorders

Conditions:   Mucopolysaccharidosis Type I;   Mucopolysaccharidosis Type II;   Mucopolysaccharidosis Type VI;   Mucopolysaccharidosis Type IV;   Mucopolysaccharidosis Type VII
Intervention:  
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 2017

Adolescent Master Protocol

Condition:   HIV/AIDS
Intervention:  
Sponsors:   Harvard School of Public Health;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute on Drug Abuse (NIDA);   National Institute of Allergy and Infectious Diseases (NIAID);   National Institute of Mental Health (NIMH);   National Heart, Lung, and Blood Institute (NHLBI);   National Institute on Deafness and Other Communication Disorders (NIDCD);   National Institute on Alcohol Abuse and Alcoholism (NIAAA);   National Institute of Neurological Disorders and Stroke (NINDS);   Tulane University School of Medicine;   National Institute of Dental and Craniofacial Research (NIDCR);   NIH Office of AIDS Research (OAR)
Active, not recruiting - verified January 2017

Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic Hypotension

Conditions:   Orthostatic Hypotension;   Pure Autonomic Failure;   Multiple System Atrophy;   Parkinson's Disease
Intervention:  
Sponsors:   Vanderbilt University Medical Center;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified January 2017

Surveillance Monitoring for ART Toxicities Study in HIV Uninfected Children Born to HIV Infected Women

Condition:   Antiretroviral Toxicity
Intervention:  
Sponsors:   Harvard School of Public Health;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute on Drug Abuse (NIDA);   National Institute of Allergy and Infectious Diseases (NIAID);   National Institute of Mental Health (NIMH);   National Heart, Lung, and Blood Institute (NHLBI);   National Institute on Deafness and Other Communication Disorders (NIDCD);   National Institute on Alcohol Abuse and Alcoholism (NIAAA);   National Institute of Neurological Disorders and Stroke (NINDS);   Tulane University School of Medicine;   National Institute of Dental and Craniofacial Research (NIDCR);   NIH Office of AIDS Research (OAR)
Recruiting - verified January 2017

Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure

Conditions:   Hypertension;   Pure Autonomic Failure;   Multiple System Atrophy
Interventions:   Drug: Losartan;   Drug: Captopril;   Drug: Placebo
Sponsor:   Vanderbilt University
Recruiting - verified January 2017

Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET)

Conditions:   High Risk Polycythemia Vera;   High Risk Essential Thrombocythemia
Interventions:   Drug: PEGASYS;   Drug: Hydroxyurea;   Drug: Aspirin
Sponsors:   Ronald Hoffman;   Myeloproliferative Disorders-Research Consortium;   National Cancer Institute (NCI);   Roche Pharma AG
Active, not recruiting - verified January 2017

Pegylated Interferon Alfa-2a Salvage Therapy in High Risk Polycythemia Vera (PV) or Essential Thrombocythemia (ET)

Conditions:   High Risk Polycythemia Vera;   High Risk Essential Thrombocythemia
Interventions:   Drug: PEGASYS;   Drug: Aspirin
Sponsors:   Ronald Hoffman;   Myeloproliferative Disorders-Research Consortium;   National Cancer Institute (NCI);   Roche Pharma AG
Completed - verified January 2017

Pulmonary Embolism and Stroke in Patient With Patent Foramen Ovale

Conditions:   Recent Stroke;   Pulmonary Embolism;   Patent Foramen Ovale
Intervention:  
Sponsor:   University Hospital, Brest
Completed - verified January 2017

Ethanol Response in Essential Tremor: Clinical and Neurophysiological Correlates

Condition:   Essential Tremor
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified January 2017

Establishment of Biomarkers for Fabry Disease

Condition:   Fabry Disease
Intervention:   Other: Fluorescein angiography
Sponsors:   Ohio State University;   Genzyme, a Sanofi Company
Completed - verified January 2017

Drug-Eluting Stents vs. Bare Metal Stents In Saphenous Vein Graft Angioplasty

Condition:   Saphenous Vein Graft Atherosclerosis
Interventions:   Device: Bare Metal Stent;   Device: Drug-Eluting Stent;   Drug: Blinded clopidogrel;   Drug: Placebo;   Drug: Thienopyridine (open-label)
Sponsor:   VA Office of Research and Development
Completed - verified January 2017

Assess the Ability of Electrical Cardiometry to Trend Hemodynamic Variables During Dexmedetomidine Sedation

Conditions:   Cardiac Output;   Sedation
Intervention:  
Sponsor:   Boston Children’s Hospital
Completed - verified June 2011

Live Kidney Donor Study - Cross-Sectional and Historical Cohort Study

Conditions:   End Stage Renal Disease;   Transplantation
Intervention:  
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   National Heart, Lung, and Blood Institute (NHLBI);   Health Resources and Services Administration (HRSA)
Completed - verified January 2017

Acarbose Cardiovascular Evaluation Trial

Conditions:   Coronary Heart Disease;   Acute Coronary Syndrome;   Impaired Glucose Tolerance;   Type 2 Diabetes Mellitus (T2DM)
Interventions:   Drug: Acarbose;   Drug: Matching Placebo
Sponsors:   University of Oxford;   Bayer
Active, not recruiting - verified January 2017

CPAP Therapy in Patients With Heart Failure and Obstructive Sleep Apnea.

Conditions:   Heart Failure;   Obstructive Sleep Apnea
Interventions:   Other: Positron Emission Tomography;   Other: Positron Emission Tomography;   Other: Positron Emission Tomography
Sponsors:   Ottawa Heart Institute Research Corporation;   Heart and Stroke Foundation of Ontario
Completed - verified January 2017

Evaluation and Standardization of Ginseng and it's Components for Blood Pressure Regulation

Conditions:   Hypertension;   Blood Pressure;   Endothelial Function
Interventions:   Dietary Supplement: Korean Red Ginseng;   Dietary Supplement: Korean Red Ginseng (Panax ginseng);   Dietary Supplement: Cornstarch;   Dietary Supplement: Korean Red Ginseng (Panax Ginseng)
Sponsors:   St. Michael's Hospital, Toronto;   Heart and Stroke Foundation of Canada
Completed - verified January 2017

A Study to Evaluate the Effects of the Neuroflo Device in People Who Have Had a Stroke

Condition:   Acute Stroke
Intervention:   Device: NeuroFlo
Sponsors:   University of California, Los Angeles;   CoAxia
Withdrawn - verified January 2017

A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease

Condition:   Moderate Risk of CVD
Interventions:   Drug: Aspirin (Acetylsalicylic acid, BAYE4465);   Drug: Placebo
Sponsor:   Bayer
Completed - verified January 2017

PET and Recovery Following Revascularization (PARR 2)

Conditions:   Coronary Artery Disease;   Ventricular Dysfunction, Left
Interventions:   Procedure: Positron emission tomography: FDG viability imaging;   Other: PET imaging
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research (CIHR);   Heart and Stroke Foundation of Ontario
Completed - verified January 2017

Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

Condition:   HTLV-1
Intervention:   Drug: Hu MiK-Beta-1
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 2016

Vision Testing in Patients With Partial Seizures Receiving Either Lyrica or Placebo

Condition:   Epilepsies, Partial
Interventions:   Drug: Lyrica (pregabalin);   Drug: placebo
Sponsor:   Pfizer
Recruiting - verified January 2017

Using Smokeless Tobacco Products With Lower Nicotine Levels to Reduce Negative Effects of Smokeless Tobacco Use

Condition:   Tobacco Use Disorder
Interventions:   Other: Lower Nicotine Smokeless Tobacco Product;   Other: Behavioral Counseling
Sponsor:   National Institute on Drug Abuse (NIDA)
Completed - verified June 2008

Effectiveness of Using Tobacco Free Snuff in Reducing Negative Effects of Smokeless Tobacco Use

Condition:   Tobacco Use Disorder
Intervention:   Drug: Tobacco free snuff
Sponsor:   National Institute on Drug Abuse (NIDA)
Completed - verified June 2008