Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

DNS-3379 vs. Placebo in Stroke Rehabilitation

Condition:   Ischemic Stroke
Interventions:   Drug: DNS-3379;   Drug: Placebo
Sponsor:   Dart NeuroScience, LLC
Not yet recruiting - verified August 2017

iADAPTS to Support Strategy Training After Stroke

Conditions:   Stroke;   Adherence, Patient;   Strategy Training
Intervention:   Behavioral: Strategy Training
Sponsor:   University of Pittsburgh
Recruiting - verified August 2017

Yes/No Questionnaire for Aphasic Patients (YNQ)

Conditions:   Stroke, Acute;   Aphasia
Intervention:   Diagnostic Test: close-ended questionnaire
Sponsor:   Groupe Hospitalier de la Rochelle Ré Aunis
Not yet recruiting - verified August 2017

Pain During Injection With Botulinum Toxin in Post-stroke Spasticity Treatment

Condition:   Post-stroke Spasticity
Intervention:   Other: pain rating during injection with botulinum toxin
Sponsor:   University Hospital, Grenoble
Completed - verified August 2017

Role of the Endothelium in Stroke-like Episode Among CDG Patients

Condition:   CDG
Intervention:   Biological: Peripheral blood puncture
Sponsor:   Assistance Publique - Hôpitaux de Paris
Not yet recruiting - verified August 2017

Comparative Effectiveness and Safety Between Warfarin and Dabigatran

Condition:   Atrial Fibrillation
Interventions:   Drug: Warfarin;   Drug: Dabigatran
Sponsor:   Boehringer Ingelheim
Not yet recruiting - verified August 2017

HDL Dysfunction During the Acute Stage of Stroke

Condition:   Stroke, Acute
Interventions:   Other: Ischemic stroke;   Other: Haemorrhagic stroke
Sponsors:   Centre Hospitalier Universitaire de la Réunion;   Institut National de la Santé Et de la Recherche Médicale, France
Not yet recruiting - verified August 2017

Paediatric Arteriopathy Steroid Aspirin Project

Condition:   Arterial Ischemic Stroke
Intervention:   Drug: Methylprednisolone + prednisolone
Sponsors:   Centre Hospitalier Universitaire de Saint Etienne;   Ministry of Health, France
Not yet recruiting - verified August 2017

Study on the Efficacy of Alprostadil Injection in Patients With Acute Ischemic Stroke

Condition:   Stroke
Interventions:   Drug: Alprostadil;   Drug: Normal saline
Sponsor:   First Hospital of Jilin University
Not yet recruiting - verified August 2017

Long-Term Survival After Ischaemic Stroke: Ebrictus Study

Conditions:   Ischemic Stroke;   Thrombolytic (t-PA) Treatment;   Gender Bias;   Long Term Adverse Effects
Intervention:   Drug: IV thrombolytic (t-PA) treatment vs not
Sponsors:   Jordi Gol i Gurina Foundation;   Pla Director Malaltia Vascular Cerebral. Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS)
Completed - verified August 2017

Mental Practice in Post-stroke Subjects

Conditions:   Stroke Sequelae;   Stroke
Interventions:   Other: Physical practice;   Other: Mental practice;   Other: Videotherapy
Sponsor:   Universidade Federal do Rio Grande do Norte
Enrolling by invitation - verified August 2017

Technical Development of Clinical Laboratory Studies

Condition:   Healthy Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified August 10, 2017

Interhemispheric Interaction of Parieto-Motor Cortico-Cortical Plasticity

Condition:   Healthy Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified August 11, 2017

Therapeutic Instrumental Music Performance With Sensory-Enhanced Motor Imagery in Chronic Post-Stroke Rehabilitation

Condition:   Stroke
Interventions:   Behavioral: Therapeutic Instrumental Music Performance (TIMP);   Behavioral: TIMP with SEMI;   Behavioral: TIMP with MI
Sponsor:   University of Toronto
Recruiting - verified August 2017

Dry Needling in Stroke to Improve the Upper Limb Functionality

Conditions:   Spasticity, Muscle;   Functionality;   Quality of Life
Intervention:   Other: Dry needling
Sponsors:   Guadarrama Hospital;   University of San Jorge
Recruiting - verified August 2017

Information Recall on Informed Consent to Intravenous Thrombolysis in Patients With Acute Ischaemic Stroke.

Condition:   Stroke
Intervention:   Other: Group 1
Sponsors:   Charite University, Berlin, Germany;   Department of Neurology, Charité - Universitätsmedizin Berlin, Germany;   Department of Cardiology and Pneumology, Charité, Campus Benjamin Franklin
Recruiting - verified August 2017

Action Observation, Imagery and Execution for Stroke Rehabilitation

Condition:   Stroke
Interventions:   Behavioral: Action observation, imagery & execution;   Behavioral: Action observation;   Behavioral: Customary upper-extremity rehabilitation
Sponsor:   Chang Gung Memorial Hospital
Recruiting - verified August 2017

Adapted Solution Focused Therapy for People With Aphasia (SOFIA Trial)

Conditions:   Aphasia;   Stroke
Intervention:   Behavioral: Adapted Solution Focused Brief Therapy
Sponsor:   City, University of London
Not yet recruiting - verified August 2017

The Cohort Study of Cognitive Impairment in Chinese Hemodialysis Patients

Conditions:   Cognitive Impairment;   Hemodialysis Complication;   Outcome;   Neuropsychological Tests
Intervention:  
Sponsor:   Beijing Shijitan Hospital
Enrolling by invitation - verified August 2017

Ketamine Versus Fentanyl for Induction of Anesthesia in Septic Shock

Condition:   Septic Shock
Interventions:   Drug: Ketamine;   Drug: Fentanyl;   Drug: Midazolam
Sponsor:   Cairo University
Not yet recruiting - verified August 2017

Tai Chi Training in Stroke Survivors

Condition:   Stroke
Interventions:   Behavioral: Tai Chi;   Behavioral: Conventional exercise
Sponsor:   The Hong Kong Polytechnic University
Completed - verified August 2017

Pilot Study of Acute Stroke Using the Brainpulse™

Condition:   Stroke, Acute
Intervention:   Device: BrainPulse Device
Sponsor:   Jan Medical, Inc.
Not yet recruiting - verified August 2017

GA vs. CS for Endovascular Stroke Therapy

Conditions:   Stroke;   Endovascular Repair;   Anesthesia
Interventions:   Drug: General Anesthesia;   Drug: Conscious Sedation with Remifentanil
Sponsor:   Lawson Health Research Institute
Not yet recruiting - verified August 2017

Ruptured Aneurysms Treated With Hydrogel Coils

Condition:   Ruptured Aneurysm
Intervention:   Device: Second-generation hydrogel coils
Sponsors:   Microvention-Terumo, Inc.;   Semmes-Murphey Foundation
Not yet recruiting - verified August 2017

E-Cigarette Inner City RCT

Conditions:   Tobacco Dependence;   COPD Asthma;   Mental Illness;   Substance Use
Intervention:   Device: Improved Quality of Life of low-income Canadians that smoke tobacco and other substances
Sponsor:   Ottawa Hospital Research Institute
Not yet recruiting - verified August 2017

PD-1 Inhibition to Determine CNS Reservoir of HIV-Infection

Condition:   HIV Infections
Intervention:   Drug: Pembrolizumab
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 31, 2017

Communicating Multiple Disease Risks: A Translation of Risk Prediction Science

Condition:   Healthy Volunteers
Interventions:   Behavioral: Risk Display App;   Behavioral: Imagery Audio Recording - Sleep;   Other: Survey;   Behavioral: Imagery Audio Recording - Exercise;   Other: Text message reminders;   Other: Text Message Based Survey
Sponsor:   Washington University School of Medicine
Recruiting - verified August 2017

Use of Branched Chain Amino Acid (BCAA) Supplements for Chronic Stroke Patients

Condition:   Stroke
Interventions:   Dietary Supplement: BCAA supplement;   Other: Aerobic exercise
Sponsor:   Taipei Medical University WanFang Hospital
Not yet recruiting - verified August 2017

Venous and Cerebral Glucose Microdialysis in Neurocritical Care: Validation & Correlation

Conditions:   Traumatic Brain Injury;   Acquired Brain Injury;   Intracerebral Hemorrhage;   Subarachnoid Hemorrhage;   Ischemic Stroke
Intervention:   Device: MicroEye & ContinuMon
Sponsors:   Dr Andrew Stevens;   Probe Scientific Limited
Not yet recruiting - verified August 2017

Mantra Meditation in Subjects That Have Chronically Impaired Attention After Stroke

Condition:   Stroke Sequelae
Intervention:   Behavioral: mantra meditation
Sponsor:   University of Kentucky
Recruiting - verified August 2017

Bio-feedback Treatment for Dysphagic Post-stroke Patients

Conditions:   Dysphagia, Late Effect of Stroke;   Deglutition Disorders
Interventions:   Device: "ProComp5 Infiniti" Biofeedback;   Other: Standard Speech and Language Therapy
Sponsor:   IRCCS San Camillo, Venezia, Italy
Not yet recruiting - verified August 2017

Optimal Antithrombotic Therapy for Acute Coronary Syndrome Patients Concomitant Atrial Fibrillation Undergoing Polymer-free Drug Eluting Stent Implantation

Conditions:   Acute Coronary Syndrome (ACS);   Non-valvular Atrial Fibrillation (NVAF)
Intervention:   Drug: Triple Antibiotic
Sponsor:   The First Affiliated Hospital with Nanjing Medical University
Not yet recruiting - verified August 2017

the Effects of Cerebral Collateral Circulation on the Outcome of Leukoaraiosis in High-risk Population

Condition:   Leukoaraiosis
Intervention:  
Sponsor:   Shanghai Zhongshan Hospital
Not yet recruiting - verified August 2017

A Study of rTMS Personalized Precision Treatment of Post-stroke Depression

Condition:   Post-stroke Depression
Interventions:   Device: "personalized" rTMS+drug treatment;   Device: Traditional rTMS +drug treatment
Sponsor:   Zhujiang Hospital
Active, not recruiting - verified October 2016

Rowing Biomechanics - Effects of (In)Stability and Fatigue

Condition:   Healthy
Interventions:   Device: Stable rowing simulator;   Device: Slides based rowing simulator;   Device: Tilt board based rowing simulator
Sponsor:   University of Primorska
Completed - verified August 2017

Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia

Conditions:   Obstructive Sleep Apnea of Adult;   Hypoxia, Brain;   Sleep Apnea;   Sleep Disorder;   Stroke;   Blood Pressure;   Endothelial Dysfunction;   Oxidative Stress
Interventions:   Drug: Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep;   Drug: Drug Lowering CBF and Intermittent Hypoxia Sleep;   Drug: Placebo and Normoxia Sleep;   Drug: Placebo and Intermittent Hypoxia Sleep
Sponsor:   University of Calgary
Not yet recruiting - verified August 2017

The Impact of Obesity on Postoperative Outcomes Following Cardiac Surgery

Conditions:   Obesity;   Cardiac Disease;   Cardiovascular Syndromes, Metabolic
Intervention:   Procedure: cardiac surgery
Sponsors:   Cardiovascular Research New Brunswick;   Horizon Health Network;   Maritime Heart Centre
Recruiting - verified August 2017

GLOBAL LEADERS Adjudication Sub-Study

Conditions:   Coronary Artery Disease;   Platelet-aggregation Inhibitors
Intervention:  
Sponsors:   University Hospital Inselspital, Berne;   European Cardiovascular Research Center
Active, not recruiting - verified August 2017

Cardiovascular Outcomes in Participants With Type 2 Diabetes Mellitus (T2DM)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Canagliflozin;   Drug: Empagliflozin;   Drug: Dapagliflozin;   Drug: Dipeptidyl Peptidase-4 Inhibitor (DPP-4);   Drug: Glucagon-Like Peptide-1 Agonist (GLP-1);   Drug: Thiazolidinedione (TZD);   Drug: Sulfonylureas;   Drug: Insulin
Sponsor:   Janssen Research & Development, LLC
Active, not recruiting - verified August 2017

Duration of Dual Anti-Platelet Therapy (DUAL-ACS2)

Conditions:   Acute Coronary Syndrome;   Coronary Artery Disease
Interventions:   Other: 3 months dual anti-platelet therapy;   Other: 12 months dual anti-platelet therapy
Sponsors:   University of Edinburgh;   British Heart Foundation
Not yet recruiting - verified August 2017

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Conditions:   Frontotemporal Lobar Degeneration;   Amytrophic Lateral Sclerosis;   Progressive Supranuclear Palsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 14, 2017

Pathophysiology of Dystonia and Complex Regional Pain Syndrome

Conditions:   Dystonia;   Complex Regional Pain Syndromes
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified July 7, 2017

Measuring the Latency Connectome in the Central Nervous Systems Using Neuroimaging and Neurophysiological Techniques

Condition:   Healthy Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified July 10, 2017

Stroke Volume Variation vs Central Venous Pressure Guidance Fluid Management in Endovascular Aortic Repair

Condition:   Postoperative Complications
Intervention:   Procedure: Fluid management protocol
Sponsor:   Khon Kaen University
Completed - verified August 2017

CPR Training in Students to Increase Bystander Intervention in Out-of-hospital Cardiac Arrest.

Condition:   Coping Skills
Interventions:   Other: web course;   Other: CPR training
Sponsor:   Karolinska Institutet
Completed - verified August 2017

Needs Assessment and Quality of Life of Stroke Patients and Their Caregivers

Condition:   Stroke Patients and Their Caregivers
Intervention:  
Sponsor:   Hospices Civils de Lyon
Not yet recruiting - verified August 2017

Current Practices of Upper Limb Rehabilitation After Stroke

Conditions:   Stroke;   Upper Extremity Paresis;   Survey
Interventions:   Other: Survey therapists;   Other: Survey patients
Sponsor:   University Ghent
Completed - verified August 2017

RNA Sequencing in the Framingham Heart Study Third Generation Cohort Exam 2

Conditions:   Cardiovascular Disease;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation - verified July 14, 2017

Compression Bandages in Upper Limb Lymphedema

Condition:   Lymphedema
Interventions:   Device: Multilayer bandage;   Device: Double compression bandage;   Device: Cohesive bandage;   Device: Adhesive compression bandage;   Device: Kinesiotaping bandage;   Other: Manual lymphatic drainage (MLD) + Intermittent Pneumatic Compression;   Other: Upper limb exercises;   Behavioral: Educational strategy
Sponsor:   University of Alcala
Active, not recruiting - verified August 2017

The Effect of Nitroglycerin Infusion Rate on Cerebral Rewarming During Hypothermic Coronary Artery Bypass Grafting

Conditions:   Coronary Artery Bypass;   Cardiopulmonary Bypass
Interventions:   Drug: Glyceryl trinitrate 0.2;   Drug: Glyceryl trinitrate 0.5
Sponsor:   Rize Üniversitesi
Not yet recruiting - verified August 2017

Loss of Depotentiation in Focal Dystonia

Conditions:   Focal Dystonia;   Healthy Volunteers
Intervention:   Other: PAS25-cTBS150
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified June 28, 2017

Safety of DS-1040b in Acute Ischemic Stroke Patients Treated With Thrombectomy

Condition:   Acute Ischemic Stroke
Interventions:   Drug: DS1040b;   Drug: Placebo
Sponsor:   Daiichi Sankyo Co., Ltd.
Recruiting - verified August 2017

Role of CT Perfusion in Predicting Poor Outcome After Subarachnoid Hemorrhage

Conditions:   Subarachnoid Hemorrhage;   Cerebral Vasospasm;   Delayed Cerebral Ischemia
Intervention:  
Sponsor:   Assiut University
Recruiting - verified August 2017

Pilot Study of Pre-Ischemic Conditioning for Intracranial Atherosclerosis

Condition:   Intracranial Atherosclerosis
Interventions:   Device: Doctormate;   Other: Usual Care
Sponsors:   Medical University of South Carolina;   University of Southern California;   University of California, Los Angeles;   Augusta University
Recruiting - verified June 2017

XIENCE Short Dual Antiplatelet Therapy (DAPT) Study

Condition:   Coronary Artery Lesions
Interventions:   Device: XIENCE;   Drug: DAPT
Sponsor:   Abbott Vascular
Recruiting - verified August 2017

Patients' Assessment of Satisfaction for Stroke Prevention in Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Drug: Pradaxa®
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2017

Stroke - 65 Plus. Continued Active Life.

Conditions:   Self-management;   Quality of Life
Intervention:   Behavioral: Mentor
Sponsors:   Central Jutland Regional Hospital;   The Velux Foundation, Denmark.;   Neurocenter of the Municipality of Aarhus, Denmark;   Hjernesagen, Denmark
Not yet recruiting - verified August 2017

The Recurrence Study

Conditions:   Acute Stroke;   Transient Ischemic Attack
Interventions:   Diagnostic Test: Corneal Confocal Imaging;   Diagnostic Test: Magnetic resonance Imaging;   Other: Blood sample
Sponsor:   Hamad Medical Corporation
Recruiting - verified August 2017

A Real-World Comparison of Safety and Effectiveness of Novel Oral Anti-Coagulant (NOAC) Naïve and Warfarin Naïve Non-Valvular Atrial Fibrillation (NVAF) Patients With Medicare Advantage Coverage

Condition:   Atrial Fibrillation
Interventions:   Drug: Apixaban;   Drug: Dabigatran;   Drug: Rivaroxaban;   Drug: Warfarin
Sponsor:   Bristol-Myers Squibb
Completed - verified June 2017

Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk

Condition:   Hypoxic-Ischemic Encephalopathy
Interventions:   Device: nfant feeding solution;   Device: Waveguard (TM) EEG cap;   Device: BabyMEG
Sponsor:   Boston Children’s Hospital
Recruiting - verified August 2017

Efficacy of Massage for the Treatment of Cancer-Related Fatigue (CRF) in Prostate Cancer Survivors

Condition:   Cancer-related Problem/Condition
Interventions:   Other: Swedish Massage Therapy;   Other: Light Touch Intervention
Sponsor:   Emory University
Recruiting - verified August 2017

Chinese Observational Prospective Study of Aging Population With Chronic Kidney Disease(C-OPTION)

Condition:   Chronic Kidney Disease
Intervention:  
Sponsors:   Chinese PLA General Hospital;   First Affiliated Hospital, Sun Yat-Sen University;   Fudan University;   China-Japan Friendship Hospital;   The First Affiliated Hospital of Dalian Medical University;   Shandong Provincial Hospital;   Beijing Friendship Hospital;   RenJi Hospital;   Hebei Medical University Third Hospital;   Second Hospital of Jilin University;   Renmin Hospital of Wuhan University
Not yet recruiting - verified August 2017

Can we Train Patients With Chronic Stroke Out of Abnormal Hand Synergy?

Condition:   Cerebral Stroke
Interventions:   Device: Real tDCS;   Device: Sham tDCS;   Behavioral: Configuration task
Sponsor:   Johns Hopkins University
Recruiting - verified August 2017

Improving Functional Outcomes and Neuroplasticity by Using Ekso

Condition:   Stroke
Intervention:   Device: EKso training
Sponsor:   IRCCS Centro Neurolesi "Bonino-Pulejo"
Completed - verified August 2017

WATCH-TAVR, WATCHMAN for Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement

Conditions:   Atrial Fibrillation;   Aortic Valve Stenosis
Interventions:   Device: WATCHMAN;   Device: TAVR
Sponsors:   Samir Kapadia;   Boston Scientific Corporation;   The Cleveland Clinic
Not yet recruiting - verified August 2017

The Safety and Efficacy of Peri-procedure Blood Pressure Management of Revascularization

Conditions:   Cerebral Revascularization;   Ischemic Cerebrovascular Disease
Interventions:   Other: model controlling;   Other: conventional controlling
Sponsors:   Xuanwu Hospital, Beijing;   Beijing Tiantan Hospital;   Peking University Third Hospital;   The 306 Hospital of People's Liberation Army
Recruiting - verified August 2017

Diagnosis Accuracy of Abdominal Compression and Hemoconcentration to Detect Diuretic Induced Fluid Removal Intolerance.

Conditions:   Hypovolemia;   Diuretic Toxicity;   Fluid Overload
Interventions:   Diagnostic Test: Abdominal compression (AC);   Diagnostic Test: blood sample
Sponsor:   Hopital Louis Pradel
Recruiting - verified August 2017

Activity Levels and Rehabilitation Outcomes of Patients Post-stroke

Condition:   Stroke
Intervention:   Other: activity monitors
Sponsors:   Florida Gulf Coast University;   Brookdale Center for Healthy Aging & Rehabilitation
Not yet recruiting - verified August 2017

Comparison of Total Intravenous Anesthesia vs. Inhalational Anesthesia in Acute Subdural Hematoma Patients

Condition:   Acute Subdural Hematoma
Interventions:   Drug: Propofol;   Drug: Isoflurane
Sponsor:   Jawaharlal Institute of Postgraduate Medical Education & Research
Recruiting - verified August 2017

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics (CREST-H)

Conditions:   Internal Carotid Artery Stenosis;   Cognitive Impairment
Intervention:  
Sponsors:   Columbia University;   National Institute of Neurological Disorders and Stroke (NINDS);   Mayo Clinic;   University of Alabama at Birmingham;   University of Maryland
Not yet recruiting - verified April 2017

Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

Condition:   Multiple Sclerosis
Interventions:   Drug: Pioglitazone;   Drug: Montelukast;   Drug: Losartan;   Drug: Hydroxychloroquine
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 6, 2017

Does N-Acetylcysteine Decrease Spontaneous Oxidation of Central Neural Dopamine in Parkinson's Disease?

Condition:   Parkinson Disease
Interventions:   Dietary Supplement: N-Acetylcysteine;   Procedure: Lumbar Puncture;   Radiation: Fluoroscopy
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 10, 2017

Ketamine Versus Low Dose Thiopental for Induction of Anesthesia in Septic Shock

Condition:   Septic Shock
Interventions:   Drug: Ketamine;   Drug: Thiopental
Sponsor:   Cairo University
Recruiting - verified August 2017

Sleep as a Model to Understand and Manipulate Cortical Activity in Order to Promote Functional Recovery After Stroke

Condition:   Hemispatial Neglect
Interventions:   Device: Transcranial Magnetic Stimulation (TMS);   Device: Transcranial Alternating Current Stimulation (tACS);   Device: sham Transcranial Magnetic Stimulation (TMS);   Device: sham Transcranial Alternating Current Stimulation (tACS)
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified August 2017

Mechanisms of Arm Recovery in Stroke Patients With Hand Paralysis

Conditions:   Stroke;   Hemiparesis;   Cerebral Vascular Accident;   Stroke, Ischemic
Interventions:   Procedure: Unaffected Transcranial Magnetic Stimulation;   Procedure: Affected Transcranial Magnetic Stimulation;   Procedure: Control Transcranial Magnetic Stimulation
Sponsors:   George Mason University;   MedStar National Rehabilitation Network
Recruiting - verified August 2017

BeyondSilos - More Personalised and Coordinated Care and Improved Outcomes for Elderly Patients

Conditions:   Heart Failure;   Stroke;   COPD;   Diabetes
Intervention:   Other: New Care
Sponsor:   Him SA
Active, not recruiting - verified August 2017

SpecTRA; A Study of the Validation of Protein Biomarkers in Transient Ischemic Attack

Condition:   TIA
Intervention:   Other: Non-Interventional Study
Sponsors:   Andrew Penn;   Genome Canada;   Genome British Columbia;   Genome Alberta;   Vancouver Island Health Authority;   LifeLabs;   Heart and Stroke Foundation of Canada;   Stroke Services BC;   Bruker Daltonics;   British Columbia Centre for Disease Control
Completed - verified August 2017

Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS

Conditions:   Aortic Valve Stenosis;   Hypertrophy, Left Ventricular
Intervention:   Procedure: Aortic valve intervention
Sponsors:   University of Edinburgh;   Sir Jules Thorn Charitable Trust
Recruiting - verified August 2017

Evaluation of Transcatheter Aortic Valve Replacement Compared to SurveilLance for Patients With AsYmptomatic Severe Aortic Stenosis

Conditions:   Aortic Stenosis;   Heart Diseases
Intervention:   Device: Edwards SAPIEN 3 THV
Sponsor:   Edwards Lifesciences
Recruiting - verified August 2017

The Comparative Safety and Effectiveness of Dabigatran, Versus Rivaroxaban, and Apixaban Utilized in the Department of Defense Non-Valvular Atrial Fibrillation Patient Population: A Retrospective Database Analysis

Condition:   Atrial Fibrillation
Interventions:   Drug: Dabigatran vs. Rivaroxaban;   Drug: Dabigatran vs. Apixaban
Sponsors:   Boehringer Ingelheim;   Health ResearchTx, LLC (HRTX);   inVentiv Health Clinical (iVH);   United States Department of Defense (DOD)
Recruiting - verified August 2017

Assessment of the St Jude Medical Portico Resheathable Aortic Valve System-Alternative Access

Condition:   Aortic Valve Stenosis
Intervention:   Device: TAVI
Sponsor:   St. Jude Medical
Recruiting - verified August 2017

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

Condition:   Mitral Valve Failure
Interventions:   Device: Edwards SAPIEN 3 transcatheter heart valve;   Device: ASHI INTECC Astato XS 20
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation - verified August 18, 2017

The Influence of Exercise on Neuroplasticity and Motor Learning After Stroke

Conditions:   Stroke;   Exercise;   Rest
Interventions:   Behavioral: Exercise;   Behavioral: Practice
Sponsor:   University of British Columbia
Recruiting - verified August 2017

Left Atrial Function in Recurrent Stroke of Unknown Cause

Condition:   Stroke
Intervention:  
Sponsors:   Hasselt University;   Jessa Hospital
Completed - verified August 2017

Fixed Low-dose Heparin Versus Standard Adjusted-dose Heparin Infusion in Adults Receiving Venovenous ECMO With a Heparin Bonded Circuit.

Conditions:   Acute Respiratory Failure;   Extracorporeal Membrane Oxygenation Complication;   Bleeding
Intervention:   Drug: HEP-IV
Sponsor:   University of Arizona
Withdrawn - verified August 2017

Effects Of Adjuvants to Caudal Anesthesia on Hemodynamics Measured By Electrical Cardiometry In Children

Condition:   Caudal Block
Interventions:   Drug: Caudal block with dexmedetomedine;   Drug: Caudal dexamethasone;   Drug: Control (bupivacaine)
Sponsor:   Kasr El Aini Hospital
Enrolling by invitation - verified August 2017

Quantitative Coronary Angiography Versus Intravascular Ultrasound GUIDancE for Drug-Eluting Stent Implantation

Conditions:   Coronary Disease;   Coronary Stenoses
Interventions:   Device: quantitative coronary angiography guided coronary intervention with sirolimus-eluting Orsiro stent;   Device: intravascular ultrasound guided coronary intervention with sirolimus-eluting Orsiro stent
Sponsors:   CHEOL WHAN LEE, M.D., Ph.D;   Biotronik SE & Co. KG
Recruiting - verified August 2017

Study of Access Site for Enhancing PCI in STEMI for Seniors (SAFE STEMI for Seniors)

Condition:   Myocardial Infarction
Interventions:   Device: Single Vessel Disease;   Procedure: Multi-vessel Disease, Culprit Vessel Only;   Procedure: Multi-vessel Disease, Complete Revascularization;   Device: Medtronic Resolute family of stents;   Device: Volcano based pressure wires Verrata, Verrata Plus and any subsequent marketed Volcano pressure wire technology;   Device: Terumo Glidesheath Slender;   Device: Terumo TR Band Radial Compression Device
Sponsors:   David Kong, M.D.;   Medtronic Vascular;   Volcano Corporation;   Terumo Medical Corporation
Not yet recruiting - verified August 2017

Stepping Training Using Feedback in Stroke

Condition:   Cerebrovascular Accident
Intervention:   Other: Stepping training with feedback
Sponsor:   Khon Kaen University
Active, not recruiting - verified August 2017

Water Immersion in Chronic Stable Heart Failure

Condition:   Heart Failure
Intervention:   Other: water immersion
Sponsor:   Hull and East Yorkshire Hospitals NHS Trust
Completed - verified October 2016

Mechanisms of Cerebrovascular Control

Condition:   Metabolic Syndrome X
Interventions:   Drug: NOS Inhibition;   Drug: ET-1 Inhibition;   Drug: Placebo;   Device: 3 Tesla MRI;   Device: Intravenous Catheter;   Other: Oral Glucose Tolerance Test
Sponsor:   University of Wisconsin, Madison
Recruiting - verified August 2017

FINE75+: 5 Year Follow up

Conditions:   Non ST Elevation Myocardial Infarction (NSTEMI);   Frailty
Intervention:   Other: This is an observational study
Sponsor:   Linkoeping University
Completed - verified March 2017

CLOSE to CURE Study

Condition:   Atrial Fibrillation
Intervention:   Procedure: Pulmonary vein isolation
Sponsor:   AZ Sint-Jan AV
Active, not recruiting - verified August 2017

Does the Response to a Mini-fluid Challenge of 3ml/kg in 2 Minutes Predict Fluid Responsiveness for Pediatric Patient?

Condition:   Anesthesia
Intervention:   Drug: fluid challenge
Sponsor:   Hospices Civils de Lyon
Recruiting - verified August 2017

A Clinical Trial Comparing Efficacy and Safety of Dabigatran Etexilate With Warfarin in Patients With Cerebral Venous and Dural Sinus Thrombosis (RE-SPECT CVT)

Condition:   Thromboembolism
Interventions:   Drug: Dabigatran etexilate;   Drug: Warfarin
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2017

Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND)

Condition:   Anaemia
Interventions:   Drug: Daprodustat;   Drug: Darbepoetin alfa;   Drug: Placebo;   Drug: Iron Therapy
Sponsor:   GlaxoSmithKline
Recruiting - verified August 2017

Effectiveness of FACoT for Individuals Post Stroke

Condition:   Stroke
Intervention:   Other: FacoT
Sponsors:   Bait Balev Hospital;   Tel Aviv University
Recruiting - verified August 2017

Benefit-Risk Of Arterial THrombotic prEvention With Rivaroxaban for Atrial Fibrillation in France

Condition:   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Vitamin K antagonists;   Drug: dabigatran (Pradaxa)
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting - verified August 2017

Clinical Study to Compare the Efficacy and Safety of Ponesimod to Placebo in Subjects With Active Relapsing Multiple Sclerosis Who Are Treated With Dimethyl Fumarate (Tecfidera®)

Condition:   Multiple Sclerosis
Interventions:   Drug: Ponesimod;   Other: Placebo
Sponsor:   Actelion
Recruiting - verified August 2017

Combine Transcranial Direct Current Stimulation and Neuromuscular Electrical Stimulation on Stroke Patients

Condition:   Stroke
Interventions:   Device: Combination of tDCS and NMES;   Device: Combination of tDCS and sham NMES;   Device: Combination of sham tDCS and sham NMES
Sponsor:   Kaohsiung Medical University Chung-Ho Memorial Hospital
Recruiting - verified August 2017

Brain and Cognitive Reserve

Condition:   Brain Ischemia
Intervention:   Other: neurologic and neuropsychological evaluation
Sponsor:   Hospices Civils de Lyon
Recruiting - verified August 2017

Effect of Tadalafil on Cerebral Large Arteries in Stroke

Conditions:   Stroke, Lacunar;   Cerebral Small Vessel Diseases
Interventions:   Drug: Tadalafil;   Drug: Placebo
Sponsor:   Christina Kruuse
Completed - verified August 2017

Nursing Home Care Intervention Post Stroke

Condition:   Stroke
Intervention:   Other: Nursing educational intervention
Sponsor:   Hospital de Clinicas de Porto Alegre
Active, not recruiting - verified August 2017

Comparison of Prasugrel and Ticagrelor in the Treatment of Acute Myocardial Infarction

Conditions:   Myocardial Infarction;   Angioplasty, Balloon, Coronary;   Platelet Aggregation Inhibitors
Interventions:   Drug: Prasugrel;   Drug: Ticagrelor
Sponsor:   Faculty Hospital Kralovske Vinohrady
Completed - verified August 2017

Treatment Convenience in Patients Treated With Dabigatran for Stroke Prophylaxis in Atrial Fibrillation (SPAF)

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2017

TMS as a Biological Marker of Neuroplasticity

Conditions:   Stroke;   Aphasia
Intervention:   Device: Transcranial Magnetic Stimulation
Sponsor:   University of Pennsylvania
Recruiting - verified August 2017

Safety and Efficacy of Two Doses of SP-8203 in Patients With Ischemic Stroke Requiring rtPA

Condition:   Ischemic Stroke
Interventions:   Drug: SP-8203 High dose;   Drug: SP-8203 Low dose;   Drug: Placebo
Sponsor:   Shin Poong Pharmaceutical Co. Ltd.
Active, not recruiting - verified January 2017

Patient Convenience Study- NIS RELATE

Condition:   Atrial Fibrillation
Interventions:   Drug: Pradaxa (dabigatran);   Drug: Vitamin K antagonist
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2017

Xarelto on Prevention of Stroke and Non-central Nervous System Systemic Embolism in Patients With Non-valvular Atrial Fibrillation in China: A Non-interventional Study

Condition:   Stroke
Intervention:   Drug: Rivaroxaban (Xarelto, BAY 59-7939)
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting - verified August 2017

STrategic Reperfusion in Elderly Patients Early After Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Drug: Tenecteplase;   Drug: Clopidogrel;   Procedure: Coronary angiography;   Procedure: Primary PCI
Sponsors:   Katholieke Universiteit Leuven;   Boehringer Ingelheim;   Life Sciences Research Partners;   Fund for Clinical Cardiovascular Research at LRD
Recruiting - verified August 2017

Transfemoral Transcatheter Aortic Valve Implantation With or Without Predilation of the Aortic Valve (EASE-IT TF)

Condition:   Aortic Stenosis
Interventions:   Other: with BAV;   Other: without BAV
Sponsor:   Institut für Pharmakologie und Präventive Medizin
Recruiting - verified August 2017

Carotid Atherosclerosis : Innovative Imaging Biomarkers. Study Case-control

Condition:   Carotid Stenosis
Intervention:   Device: HITS quantification, Ultrasound examinations, High Resolution MRI
Sponsors:   Hospices Civils de Lyon;   Fondation de France;   Bracco Imaging S.p.A.
Recruiting - verified August 2017

CT COMPARE: CT COronary Angiography to Measure PlAque REduction

Condition:   Cardiovascular Disease
Interventions:   Drug: Rosuvastatin;   Drug: Atorvastatin
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified August 9, 2017

Dedicated Ambulator-assisted Physical Activity to Improve Hospital Outcome Measures in Elderly Patients

Conditions:   Weakness;   Hospital Acquired Condition
Intervention:   Other: Ambulation
Sponsor:   The Cleveland Clinic
Completed - verified August 2017

Virtual Occupational Therapy Application

Conditions:   Stroke;   Hemiparesis
Intervention:   Behavioral: VOTA Therapy
Sponsors:   Barron Associates, Inc.;   University of Virginia
Completed - verified August 2017

A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Recruiting - verified August 2017

The PARTNER II Trial: S3iCAP

Condition:   Aortic Stenosis
Intervention:   Device: TAVR with SAPIEN S3 valve
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified August 2017

Safety and Tolerability of PF-05230907 in Intracerebral Hemorrhage

Condition:   Intracerebral Hemorrhage
Intervention:   Biological: PF-05230907
Sponsor:   Pfizer
Recruiting - verified August 2017

The PARTNER 3 - Trial - The Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis

Condition:   Aortic Stenosis
Interventions:   Procedure: Surgical aortic valve replacement (SAVR);   Device: Transcatheter Aortic Valve Replacement (TAVR)
Sponsor:   Edwards Lifesciences
Recruiting - verified July 2017

Influence of a Multi-parametric Optimization Strategy for General Anesthesia on Postoperative Morbidity and Mortality

Conditions:   Coronary; Ischemic;   Arrhythmias, Cardiac;   Heart Failure;   Peripheral Vascular Diseases;   Dementia;   Stroke;   Pulmonary Disease, Chronic Obstructive;   Respiratory Insufficiency;   Alcoholism;   Cancer;   Diabetes;   Renal Insufficiency
Interventions:   Procedure: OPTI-AGED;   Procedure: Usual Care
Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
Recruiting - verified August 2017

S100B in the Care of Non-traumatic Headaches in the Emergency Department

Condition:   Headache
Interventions:   Biological: Plasma S100B levels at inclusion;   Device: Magnetic resonance imaging
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Recruiting - verified August 2017

INVEST: Minimally Invasive Endoscopic Surgery vs. Medical Management in Supratentorial Intraparenchymal Hemorrhage

Condition:   Intracranial Hemorrhage
Interventions:   Device: Apollo MIES;   Other: Medical Management
Sponsor:   J. Mocco
Recruiting - verified June 2017

A Study of the ReCor Medical Paradise System in Clinical Hypertension

Conditions:   Hypertension;   Vascular Diseases
Interventions:   Device: The Paradise® Renal Denervation Ultrasound System;   Device: Sham Procedure
Sponsor:   ReCor Medical, Inc.
Recruiting - verified May 2017

Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor

Conditions:   Traumatic Brain Injury;   Ischemic Stroke;   Intracerebral Hemorrhage;   Subarachnoid Hemorrhage;   Acute Anoxic Encephalopathy
Intervention:   Drug: Indocyanine Green
Sponsor:   University of Pennsylvania
Recruiting - verified August 2017

Hydroxychloroquine for the Prevention of Cardiovascular Events in Myocardial Infarction Patients - a Safety Pilot Trial

Conditions:   Myocardial Infarction;   Acute Coronary Syndrome;   Inflammation;   Hydroxychloroquine;   Antirheumatic Agents;   Cardiovascular Diseases
Interventions:   Drug: Hydroxychloroquine;   Drug: Placebo
Sponsors:   Helsinki University Central Hospital;   Finnish Foundation for Cardiovascular Research;   Orion Corporation, Orion Pharma;   Aarne Koskelo Foundation;   Finnish Cultural Foundation
Recruiting - verified August 2017

Consolidating Tools for Outcomes in Resuscitation

Conditions:   Cardiac Arrest;   Cardiopulmonary Resuscitation;   Simulation;   Education
Interventions:   Device: Knowledge-based cognitive aid;   Device: Cognitive aids with roles defined (CARD);   Device: Integrated cognitive aids
Sponsors:   Ottawa Hospital Research Institute;   The Physicians' Services Incorporated Foundation;   University of Ottawa;   Children's Hospital of Eastern Ontario;   The Hospital for Sick Children;   Montreal Children's Hospital of the MUHC;   Alberta Children's Hospital;   Stollery Children's Hospital
Recruiting - verified August 2017

The Capillary Index Score Trial

Conditions:   Acute Stroke;   Brain Ischemia;   Ischemic Stroke
Intervention:   Procedure: Endovascular Treatment (EVT)
Sponsors:   Firas Al-Ali;   Stryker Neurovascular;   Rochester General Hospital;   University of Vermont Medical Center;   University of North Carolina, Chapel Hill;   New York University Langone Medical Center
Enrolling by invitation - verified August 2017

A Study to Compare Tivozanib Hydrochloride to Sorafenib in Subjects With Refractory Advanced RCC

Condition:   Carcinoma, Renal Cell
Interventions:   Drug: tivozanib hydrochloride;   Drug: Sorafenib
Sponsor:   AVEO Pharmaceuticals, Inc.
Active, not recruiting - verified August 2017

Study of the Performance of Stroke Management in the Rhône Area

Condition:   Stroke
Intervention:  
Sponsor:   Hospices Civils de Lyon
Recruiting - verified August 2017

Feasibility Study of a Left Atrial Appendage Closure Device in Patients With Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Device: Aegis Sierra Ligation System
Sponsors:   Aegis Medical Innovations;   Applied Health Research Centre
Recruiting - verified August 2017

Implantable Cardiac Monitors in High-Risk Post-Infarction Patients With Cardiac Autonomic Dysfunction

Conditions:   Myocardial Infarction;   Autonomic Nervous System Diseases
Intervention:   Device: Medtronic Reveal LINQ implantable cardiac monitor
Sponsors:   Klinikum der Universitaet Muenchen;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK);   Medtronic Bakken Research Center
Recruiting - verified August 2017

Effect of Mirror Therapy Versus Bilateral Arm Training for Rehabilitation After Chronic Stroke

Condition:   Stroke
Interventions:   Other: Mirror therapy;   Other: Bilateral arm training
Sponsor:   China Medical University Hospital
Recruiting - verified August 2017

Special Drug Use Investigation of Xarelto for Venous Thromboembolism (VTE)

Condition:   Venous Thromboembolism
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting - verified August 2017

Global Study Comparing a rivAroxaban-based Antithrombotic Strategy to an antipLatelet-based Strategy After Transcatheter aortIc vaLve rEplacement to Optimize Clinical Outcomes

Condition:   Transcatheter Aortic Valve Replacement
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Acetylsalicylic acid;   Drug: Clopidogrel
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting - verified August 2017

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified August 2017

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified August 2017

Molecular Imaging of Inflammation With 18F-PBR06 to Identify Unstable Carotid Plaques in Patients With Stroke

Condition:   Stroke
Intervention:   Drug: 18F-PBR06
Sponsor:   University Hospital, Bordeaux
Recruiting - verified August 2017

Efficacy of Subintimal vs Intraluminal Approach for Atherosclerotic Chronic Occlusive Femoropopliteal Arterial Disease

Conditions:   Peripheral Arterial Disease;   Atherosclerosis
Interventions:   Procedure: Intentional intraluminal approach;   Procedure: Intentional subintimal approach
Sponsor:   Korea University Guro Hospital
Recruiting - verified August 2017

Sideways Treadmill Training to Improve Paretic Leg Stepping in Persons Post-Stroke

Conditions:   Stroke;   Hemiparesis
Intervention:   Behavioral: treadmill training
Sponsor:   Northwestern University
Recruiting - verified August 2017

Forced Aerobic Exercise for Stroke Rehabilitation

Condition:   Stroke
Interventions:   Behavioral: Forced Exercise & Upper Extremity Repetitive Task Practice;   Behavioral: Voluntary Exercise & Upper Extremity Repetitive Task Practice;   Behavioral: Stroke Education & Upper Extremity Repetitive Task Practice
Sponsors:   The Cleveland Clinic;   American Heart Association
Active, not recruiting - verified August 2017

The Effects of CPAP Withdrawal on Cerebral Vascular Reactivity and Brain Oxygenation in OSA

Condition:   Sleep Apnea, Obstructive
Intervention:   Device: Continuous positive airway pressure device
Sponsor:   University of Zurich
Recruiting - verified August 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting - verified August 2017

Study of Modified Stem Cells (SB623) in Patients With Chronic Motor Deficit From Ischemic Stroke

Condition:   Chronic Ischemic Stroke
Interventions:   Biological: SB623 Implant (2.5M);   Biological: SB623 Implant (5.0M);   Procedure: Sham surgery
Sponsors:   SanBio, Inc.;   Sunovion
Recruiting - verified February 2017

Safety and Performance Study of the Edwards CENTERA-EU Self-Expanding Transcatheter Heart Valve

Condition:   Aortic Valve Disease
Intervention:   Device: Edwards CENTERA Self-Expanding Transcatheter Heart Valve
Sponsors:   Edwards Lifesciences;   Medstar Health Research Institute;   European Cardiovascular Research Center;   University of British Columbia
Active, not recruiting - verified February 2017

Feasibility of Using Prism Adaptation to Treat Spatial Neglect and Motor Function in Stroke

Condition:   Stroke
Intervention:   Behavioral: Prism Adaptation
Sponsor:   Kessler Foundation
Completed - verified August 2017

Post-Market Clinical Follow-Up Study to Confirm Clinical Performance and Safety of the Codman Enterprise® 2 Vascular Reconstruction Device in the Endovascular Treatment of Intracranial Aneurysms

Condition:   Intracranial Aneurysm
Intervention:   Device: Enterprise 2 Vascular Reconstruction Device
Sponsor:   Codman & Shurtleff
Recruiting - verified August 2017

Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension

Condition:   Hypertension
Interventions:   Drug: Trimethaphan;   Drug: Nitroglycerin
Sponsor:   Vanderbilt University
Recruiting - verified August 2017

Effect of Serotonin and Levodopa in Ischemic Stroke

Condition:   Stroke
Interventions:   Other: placebo;   Drug: citalopram;   Drug: sinemet plus
Sponsor:   Hospital de Granollers
Recruiting - verified August 2017

Identification of Novel Molecular Markers for Cerebral Ischemia From Patients With Minor and Devastating Ischemic Injury

Condition:   Cerebral Ischemia
Intervention:  
Sponsors:   St. Joseph's Hospital and Medical Center, Phoenix;   Translational Genomics Research Institute;   National Institutes of Health (NIH)
Active, not recruiting - verified August 2017

Telerehabilitation in the Home Versus Therapy In-Clinic for Patients With Stroke

Condition:   Stroke
Interventions:   Device: Telerehabilitation Therapy;   Behavioral: In-Clinic Therapy
Sponsor:   University of California, Irvine
Recruiting - verified August 2017

Influence on Plasticity of Brain Temperature

Condition:   Healthly Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 12, 2017

Role of PPAR-y Agonists in Immunomodulation and Vascular Prevention in SLE (PPAR-SLE)

Condition:   Systemic Lupus Erthematosus
Interventions:   Radiation: PET/CT;   Drug: Pioglitazone;   Procedure: Vascular function studies
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified July 24, 2017

Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS)

Condition:   Stroke
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin (Acetylsalicylic acid, BAY1019036);   Other: Rivaroxaban-Placebo;   Other: Aspirin-Placebo
Sponsors:   Bayer;   Janssen, LP;   Hamilton Health Sciences Cooperation, Population Health Research Institute
Recruiting - verified August 2017

Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID)-2.0

Condition:   Hypertension
Intervention:  
Sponsors:   National Human Genome Research Institute (NHGRI);   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified August 3, 2017

The Multidisciplinary, Multimodality, But Minimalist Approach to Transfemoral Transcatheter Aortic Valve Replacement

Condition:   Aortic Valve Stenosis
Intervention:   Other: Vancouver 3M Clinical Pathway
Sponsors:   BC Centre for Improved Cardiovascular Health;   University of British Columbia
Active, not recruiting - verified August 2017

Neurocognitive and Radiological Assessments in Adult Moyamoya Undergoing Surgery

Condition:   Moyamoya Disease
Interventions:   Procedure: Surgical Revascularization;   Other: Conservative treatment
Sponsor:   Huashan Hospital
Recruiting - verified August 2017

RuSsian RegisTry of Acute CoronaRy SyndromE TreAtMent and Approach in Dual Antiplatelet Therapy

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   AstraZeneca
Active, not recruiting - verified August 2017

Acupuncture for Cerebral Vasospasm After Subarachnoid Hemorrhage

Conditions:   SAH (Subarachnoid Hemorrhage);   Cerebral Vasospasm
Interventions:   Device: acupuncture;   Device: Electroacupuncture;   Device: Intradermal acupuncture;   Device: Mock transcutaneous electrical nerve stimulation;   Device: sham intradermal acupuncture
Sponsor:   Kyung Hee University Hospital at Gangdong
Completed - verified August 2017

Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability

Conditions:   Chronic Troublesome Sialorrhea;   Cerebral Palsy;   Stroke;   Traumatic Brain Injury;   Intellectual Disability
Interventions:   Drug: IncobotulinumtoxinA;   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Recruiting - verified August 2017

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified August 2017

Electrical Stimulation of the Paretic Upper Limb in the Early Stroke Phase

Condition:   Stroke, Acute
Interventions:   Other: Continuous, suprasensory ESS;   Other: Intermittent, suprasensory ESS
Sponsors:   University of Copenhagen;   Bispebjerg Hospital;   Region Capital Denmark;   Lundbeck Foundation;   Bevica Fonden;   Manager Jacob Madsen and his wife, Olga Madsen's Foundation;   Danish Association of Occupational Therapist
Completed - verified August 2017

Drug Persistence/Adherence in Patients Treated With Dabigatran or VKA for Stroke Prevention in Non Valvular Atrial Fibrillation (SPAF)

Condition:   Atrial Fibrillation
Interventions:   Drug: Dabigatran etexilate;   Drug: Phenprocoumon
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified August 2017

Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

Conditions:   Stroke;   Secondary Prevention
Interventions:   Drug: optional ASA as comedication;   Drug: placebo to ASA;   Drug: placebo to optional ASA as comedication;   Drug: placebo to dabigatran etexilate;   Drug: ASA 100 mg;   Drug: dabigatran etexilate
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2017

Trial to Incentivise Adherence for Diabetes

Condition:   Type 2 Diabetes Mellitus
Interventions:   Behavioral: Diabetes Educational Program (DEP);   Behavioral: DEP + Process Incentive;   Behavioral: DEP + Outcome Incentive
Sponsor:   Duke-NUS Graduate Medical School
Recruiting - verified August 2017

Active Surveillance Research Program for the Assessment of the Safety and the Effectiveness of Linagliptin

Condition:   Diabetes Mellitus, Type 2
Intervention:  
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified August 2017

The Role of Gut Microbiota in Hypertension

Condition:   Hypertension
Intervention:   Other: Stool Sample and Blood Sample
Sponsors:   University of Florida;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified August 2017

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease, on Dialysis

Condition:   Anemia
Interventions:   Drug: Roxadustat;   Drug: Epoetin alfa
Sponsors:   AstraZeneca;   FibroGen
Recruiting - verified August 2017

Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage (The PATCH Study)

Conditions:   Wounds and Injuries;   Acute Coagulopathy
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsors:   Monash University;   National Health and Medical Research Council, Australia;   Health Research Council, New Zealand
Recruiting - verified August 2017

Efficacy and Safety of Implantable Cardioverter-Defibrillator (ICD) Implantation in the Elderly

Conditions:   Cardiomyopathy;   Coronary Artery Disease;   Congestive Heart Failure;   Myocardial Infarction
Interventions:   Device: Implantable Cardioverter Defibrillator;   Other: Optimal Medical Therapy
Sponsor:   VA Office of Research and Development
Recruiting - verified August 2017

Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia

Condition:   Eligible Men or Women Considered High Risk for Atherosclerotic Cardiovascular Disease (CVD)
Interventions:   Drug: Epanova® (omega-3 carboxylic acids);   Drug: corn oil control
Sponsors:   AstraZeneca;   Cleveland Clinic Coordinating Center for Clinical Research (C5R);   Quintiles, Inc.
Active, not recruiting - verified August 2017

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy (CEA);   Device: Carotid Stenting (CAS);   Other: Intensive Medical Management - no CEA;   Other: Intensive Medical Management - no CAS
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified August 2017

Efficacy and Safety Study of rTMS for Upper Extremity Motor Function Recovery in Ischemic Stroke Patients

Conditions:   Stroke;   Hemiplegia
Intervention:   Device: Low frequency rTMS
Sponsors:   Seoul National University Bundang Hospital;   DongGuk University;   Seoul National University Hospital
Recruiting - verified August 2017

A Closed Loop Neural Activity Triggered Stroke Rehabilitation Device

Condition:   Transient Ischemic Attack
Interventions:   Device: Transcranial Magnetic Stimulation;   Behavioral: Behavioral Assessments;   Other: Magnetic Resonance Imaging;   Other: EEG
Sponsor:   University of Wisconsin, Madison
Recruiting - verified August 2017

Sequential Expansion of Comparative Effectiveness of Anticoagulants

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2017

A Clinical Trial of STAtin Therapy for Reducing Events in the Elderly (STAREE)

Conditions:   Independent Living;   Disability Free Survival;   Elderly;   Healthy
Interventions:   Drug: Atorvastatin;   Drug: Placebo (for Atorvastatin)
Sponsors:   Monash University;   National Health and Medical Research Council, Australia
Enrolling by invitation - verified August 2017

Elite Controller and ART-treated HIV+ Statin Versus ASA Treatment Intervention Study

Condition:   HIV Infection
Interventions:   Drug: Aspirin 81 mg daily;   Drug: Atorvastatin 40 mg daily
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified August 18, 2017

An Assessment of the Prevalence of Spatial Neglect in Stroke Survivors With Aphasia

Conditions:   Spatial Neglect;   Aphasia;   Stroke
Intervention:   Behavioral: prism adaptation treatment
Sponsor:   Kessler Foundation
Completed - verified August 2017

Mild and Rapidly Improving Stroke Study

Condition:   Ischemic Stroke
Intervention:  
Sponsors:   University of Miami;   American Heart Association
Recruiting - verified August 2017

Study Comparing the Diagnostic Yield of Solid Lesion Biopsies Performed by EUS-FNA Using the 25d ProCor Needle Versus the Standard 25g Needle

Condition:   Solid Lesion Biopsies
Interventions:   Device: 25g standard needle;   Device: 25d ProCor needle
Sponsor:   Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting - verified December 2016

Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency

Conditions:   Metabolic Disease;   Seizures
Interventions:   Drug: SGS-742;   Drug: Placebo
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified August 3, 2017

Ischemia Care Biomarkers of Acute Stroke Etiology (BASE)

Conditions:   Ischemic Stroke;   Atrial Fibrillation;   Transient Ischemic Attacks;   Transient Cerebrovascular Events;   Thrombotic Stroke;   Stroke of Basilar Artery;   Cardioembolic Stroke
Intervention:   Other: Biomarker blood draw
Sponsor:   Ischemia Care LLC
Recruiting - verified August 2017

Dynamic Preload Indicators in Sitting Position

Condition:   Neurosurgery in Sitting Position
Intervention:   Procedure: Sitting position (neurosurgery)
Sponsor:   Hospices Civils de Lyon
Recruiting - verified August 2017

Synergistic Enteral Regimen for Treatment of the Gangliosidoses

Conditions:   GM1 Gangliosidoses;   GM2 Gangliosidoses;   Tay-Sachs Disease;   Sandhoff Disease
Interventions:   Drug: miglustat;   Other: Ketogenic Diet
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   Lysosomal Disease Network
Active, not recruiting - verified August 2017

Safety, Tolerability and Activity Study of Ibudilast in Subjects With Progressive Multiple Sclerosis

Conditions:   Multiple Sclerosis, Primary Progressive;   Multiple Sclerosis, Secondary Progressive
Interventions:   Drug: ibudilast;   Drug: Placebo
Sponsors:   MediciNova;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   National Multiple Sclerosis Society
Completed - verified August 2017

Optimizing Antithrombotic Care in Patients With AtriaL fibrillatiON and Coronary stEnt (OAC-ALONE) Study

Conditions:   Atrial Fibrillation;   Coronary Artery Disease
Intervention:   Drug: OAC alone
Sponsors:   Satoshi Shizuta;   Research Institute for Production Development;   Daiichi Sankyo Co., Ltd.
Active, not recruiting - verified August 2017

Effect of FES Interventions on Gait Dynamics in Stroke Population

Conditions:   Stroke;   Foot Drop
Intervention:   Device: FES
Sponsors:   Kessler Foundation;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified August 2017

Detection and Neurological Impact of CerebroVascular Events In Noncardiac Surgery PatIents: A COhort EvaluatioN

Condition:   Covert Postoperative Stroke
Intervention:  
Sponsors:   Hamilton Health Sciences Corporation;   McMaster University;   Health and Medical Research Fund, Food and Health Bureau, Hong Kong;   Prince of Wales Hospital, Shatin, Hong Kong;   Chinese University of Hong Kong
Active, not recruiting - verified August 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Germany)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting - verified August 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxoban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting - verified August 2017

Adapting Daily Activity Performance Through Strategy Training

Conditions:   Strategy Training;   Attention Control
Interventions:   Behavioral: Strategy Training;   Behavioral: Attention Control
Sponsors:   University of Pittsburgh;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified August 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)

Condition:   Pulmonary Embolism
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Warfarin
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting - verified August 2017

Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation

Conditions:   Amyotrophic Lateral Sclerosis;   Frontotemporal Lobar Degeneration
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Aging (NIA)
Recruiting - verified August 4, 2017

Determining Optimal Post-Stroke Exercise (DOSE)

Conditions:   Cerebrovascular Accident;   Stroke;   Cerebral Infarction;   Brain Infarction;   Brain Ischemia;   Cerebrovascular Disorders;   Brain Diseases;   Central Nervous System Diseases;   Nervous System Diseases;   Vascular Diseases
Interventions:   Behavioral: Stroke Management Program (SMP);   Behavioral: Stroke Monitoring Program (SMonP);   Behavioral: Stroke Supplementary Program (SSP)
Sponsor:   University of British Columbia
Recruiting - verified August 2017

Eliquis Regulatory Post Marketing Surveillance

Condition:   NonValvular Atrial Fibrillation
Intervention:   Drug: Apixaban
Sponsor:   Bristol-Myers Squibb
Active, not recruiting - verified August 2017

Cardiovascular, Cerebrovascular, and Cognitive Function in Spinal Cord Injury

Condition:   Spinal Cord Injury
Intervention:  
Sponsor:   James J. Peters Veterans Affairs Medical Center
Active, not recruiting - verified August 2017

Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy

Conditions:   Intracerebral Hemorrhage;   Cerebral Amyloid Angiopathy;   Ischemic Stroke
Intervention:  
Sponsor:   Ludwig-Maximilians - University of Munich
Active, not recruiting - verified August 2017

Study Of Diabetic Nephropathy With Atrasentan

Condition:   Diabetic Nephropathy
Interventions:   Drug: Atrasentan;   Drug: Placebo
Sponsor:   AbbVie
Recruiting - verified August 2017

Improved Prevention of Stroke in Primary Care in Stockholm, Sweden (Förbättrad Prevention av Stroke)

Conditions:   Ischemic Stroke;   Hemorrhagic Stroke;   TIA;   Atrial Fibrillation
Intervention:   Behavioral: structured collegial feed back
Sponsor:   Karolinska Institutet
Enrolling by invitation - verified August 2017

Anticoagulant Utilization Pattern

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2017

Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III

Condition:   Intracerebral Hemorrhage
Intervention:   Drug: rt-PA
Sponsors:   Johns Hopkins University;   National Institute of Neurological Disorders and Stroke (NINDS);   Genentech, Inc.;   Emissary International LLC
Active, not recruiting - verified August 2017

COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure.

Conditions:   Modified Release Oral Formulation;   Left Ventricular Systolic Dysfunction;   Chronic Heart Failure;   History of Chronic Heart Failure;   Left Ventricular Ejection Fraction;   Pharmacokinetics;   Echocardiogram
Interventions:   Drug: Omecamtiv Mecarbil;   Drug: Omecamtiv Mecarbil;   Drug: Placebo;   Drug: Omecamtiv Mecarbil;   Drug: Omecamtiv Mecarbil
Sponsors:   Amgen;   Cytokinetics
Completed - verified August 2017

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2017

Adverse Effects of Systemic Hypoglycemia Exposure on Endothelial Function in Humans

Condition:   Type 2 Diabetes
Intervention:   Other: Glycemic clamping
Sponsor:   Medical College of Wisconsin
Terminated - verified April 2015

Xarelto [SPAF] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban(Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting - verified August 2017

Imaging Biomarkers in Parkinson s Disease

Condition:   Parkinson Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified June 28, 2017

Microelectrode Brain-Machine Interface for Individuals With Tetraplegia

Conditions:   Tetraplegia;   Spinal Cord Injury
Intervention:   Device: Implantation of NeuroPort Arrays in the motor cortex
Sponsors:   University of Pittsburgh;   United States Department of Defense;   Johns Hopkins University
Recruiting - verified August 2017

Evaluation and Diagnosis of Potential Research Subjects With Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Intervention:  
Sponsors:   National Institute of Nursing Research (NINR);   National Institute of Neurological Disorders and Stroke (NINDS);   Center for Neuroscience and Regenerative Medicine (CNRM)
Recruiting - verified August 11, 2017

Surgery as a Treatment for Medically Intractable Epilepsy

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Partial Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified August 9, 2017

National Epidemiologic Survey on Alcohol and Related Conditions-III

Condition:   Alcohol-Related Disorders
Intervention:  
Sponsor:   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Completed - verified August 10, 2017

Investigating Mechanism of Action of DAC HYP in the Treatment of High-Inflammatory Multiple Sclerosis (MS)

Conditions:   Multiple Sclerosis;   Multiple Sclerosis, Relapsing-Remitting
Intervention:   Biological: DAC-HYP
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified August 11, 2017

Evaluation, Pathogenesis, and Outcome of Subjects With or Suspected Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Center for Neuroscience and Regenerative Medicine (CNRM);   United States Department of Defense;   Henry M. Jackson Foundation for the Advancement of Military Medicine
Recruiting - verified August 16, 2017

Cardiovascular Safety of Febuxostat and Allopurinol in Patients With Gout and Cardiovascular Comorbidities

Condition:   Cardiovascular Disease
Interventions:   Drug: Febuxostat;   Drug: Allopurinol
Sponsors:   Takeda;   Teijin America, Inc.
Completed - verified August 2017

Top-Down Attentional Control of Visual-Processing

Conditions:   Focal Brain Lesion;   Focal Lesions;   fMRI
Intervention:  
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting - verified June 5, 2017

Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial

Condition:   Ischemic Attack, Transient
Interventions:   Drug: Clopidogrel;   Drug: placebo
Sponsors:   University of California, San Francisco;   Neurological Emergencies Treatment Trials Network (NETT);   Medical University of South Carolina;   The EMMES Corporation
Recruiting - verified August 2017

Double Blind Placebo-Controlled Phase I/II Clinical Trial of Idebenone in Patients With Primary Progressive Multiple Sclerosis (IPPoMS)

Condition:   Primary Progressive Multiple Sclerosis
Intervention:   Drug: Idebenone
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified August 3, 2017

CORonary Diet Intervention With Olive Oil and Cardiovascular PREVention

Conditions:   Myocardial Infarction;   Unstable Angina;   Malignancy;   Cognitive Decline;   Diabetes Mellitus;   Metabolic Syndrome
Interventions:   Behavioral: Mediterranean Diet;   Behavioral: Low Fat Diet
Sponsor:   Hospital Universitario Reina Sofia
Active, not recruiting - verified August 2017

Investigation of Neurofeedback With Real-Time fMRI in Healthy Volunteers and Patients With Hyperkinetic Movement Disorders

Conditions:   Movement Disorder;   Tourette Syndrome;   Healthy Volunteer
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 10, 2017

GORE® HELEX® Septal Occluder / GORE® CARDIOFORM Septal Occluder for Patent Foramen Ovale (PFO) Closure in Stroke Patients - The Gore REDUCE Clinical Study

Conditions:   Stroke;   Transient Ischemic Attack
Interventions:   Device: GORE® HELEX® Septal Occluder / GORE® CARDIOFORM Septal Occluder;   Other: Antiplatelet Medical Therapy
Sponsor:   W.L.Gore & Associates
Active, not recruiting - verified August 2017

Use of Deep Transcranial Magnetic Stimulation After Stroke

Condition:   Stroke
Interventions:   Device: Deep TMS (Transcranial magnetic stimulation);   Device: Brainsway Deep TMS
Sponsor:   Hadassah Medical Organization
Completed - verified August 2017

A Natural History Study of the Gangliosidoses

Conditions:   Tay-Sachs Disease;   Sandhoff Disease;   Late Onset Tay-Sachs Disease;   GM1 Gangliosidosis;   GM2 Gangliosidosis
Intervention:  
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   Lysosomal Disease Network
Recruiting - verified August 2017

Neurobiology of Psychogenic Movement Disorder and Non-Epileptic Seizures

Conditions:   Psycogenic Movement Disorders;   Non-epileptic Seizures
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 21, 2017

Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors

Conditions:   Cancer Survivor;   Cardiovascular Complication;   Malignant Childhood Neoplasm
Interventions:   Other: Laboratory Biomarker Analysis;   Other: Questionnaire Administration
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Recruiting - verified August 2017

Myotonic Dystrophy and Facioscapulohumeral Muscular Dystrophy Registry

Conditions:   Myotonic Dystrophy;   Facioscapulohumeral Muscular Dystrophy;   Muscular Dystrophy;   Myotonic Dystrophy Type 1;   Myotonic Dystrophy Type 2;   Congenital Myotonic Dystrophy;   PROMM (Proximal Myotonic Myopathy);   Steinert's Disease;   Myotonic Muscular Dystrophy
Intervention:  
Sponsors:   University of Rochester;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified August 2017

Relatively Healthy Male Veterans Observed Over Time to See What Types of Diseases Develop

Condition:   Healthy
Intervention:  
Sponsor:   VA Office of Research and Development
Active, not recruiting - verified August 2017

Evaluation of Primary Chronic Autonomic Failure

Condition:   Autonomic Nervous System Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified August 3, 2017

Neurotropin to Treat Chronic Neuropathic Pain

Conditions:   Complex Regional Pain Syndrome Type I;   Complex Regional Pain Syndrome Type II
Interventions:   Drug: Placebo;   Drug: Neurotropin
Sponsors:   National Institute of Nursing Research (NINR);   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Terminated - verified August 2017

Study of Brain and Spinal Cord Tumor Growth and Cyst Development in Patients With Von Hippel Lindau Disease

Conditions:   Hemangioblastoma;   Hippel Lindau Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified August 4, 2017

Genetic Analysis of the Chiari I Malformation

Conditions:   Syringomyelia;   Type I Arnold Chiari Malformation
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 5, 2016

Diagnosis of Pheochromocytoma

Condition:   Pheochromocytoma
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified June 23, 2017

Evaluation of Patients With HAM/TSP

Conditions:   HTLV-I Infection;   Tropical Spastic Paraparesis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified August 2, 2017

Botulinum Toxin for the Treatment of Involuntary Movement Disorders

Conditions:   Chorea;   Drug Induced Dyskinesia;   Movement Disorder;   Muscular Disease;   Tic Disorder
Intervention:   Other: Botulinum Toxin
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified August 11, 2017