Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Does Isolated Robotic-Assisted Gait Training Improve Functional Status, Daily Living And Quality Of Life In Stroke?

Conditions:   Cerebrovascular Stroke;   Cerebrovascular Accident;   Cerebral Stroke
Intervention:   Other: Robotic-Assisted Gait Training
Sponsor:   Istanbul University
Completed - verified April 2016

Xbox Kinect™ Training for Stroke Rehabilitation

Condition:   Stroke
Interventions:   Behavioral: Xbox Kinect™ training;   Behavioral: Conventional rehabilitation
Sponsor:   Ankara University
Completed - verified April 2016

Norwegian Carotid Plaque Study

Conditions:   Ischemic Stroke;   Carotid Artery Disease;   Embolic Stroke
Intervention:  
Sponsors:   Haukeland University Hospital;   University of Bergen
Not yet recruiting - verified April 2016

Validation of Sensitivity and Specificity of a Multi-Omic Precision Diagnostic for Acute Stroke Evaluation

Condition:   Acute Ischemic Stroke
Intervention:   Other: Non-Interventional
Sponsors:   CereDx;   University of Cincinnati
Not yet recruiting - verified April 2016

Training Dual-task Balance and Walking in People With Stroke

Condition:   Stroke
Interventions:   Other: Dual task training;   Other: Single-task training;   Other: Limbs exercise
Sponsors:   The Queen Elizabeth Hospital;   The Hong Kong Polytechnic University
Recruiting - verified April 2016

CO-OPerative Training for Stroke Rehabilitation

Conditions:   CO-OP;   Attention Control
Interventions:   Behavioral: CO-OP;   Behavioral: Attention Control
Sponsors:   University of Pittsburgh;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed - verified April 2016

Impact of Intravascular Fluid Resuscitation and Whole Blood Viscosity for CABG Surgery

Condition:   CABG Surgery
Interventions:   Drug: Intravenous Crystalloid;   Drug: Intravenous HES
Sponsor:   Konkuk University Medical Center
Not yet recruiting - verified April 2016

Impact of Intravascular Fluid Resuscitation and Whole Blood Viscosity for Cardiac Surgery

Condition:   Cardiac Surgery
Interventions:   Drug: Intravenous Crystalloid;   Drug: Intravenous HES
Sponsor:   Konkuk University Medical Center
Not yet recruiting - verified April 2016

Meditoxin® Treatment in Patients With Post Stroke Upper Limb Spasticity

Condition:   Muscle Spasticity
Interventions:   Procedure: Ultrasonography guidance injection of Meditoxin®.;   Procedure: Electrical stimulation guidance injection of Meditoxin®.;   Procedure: Manual needle placement injection of Meditoxin®.
Sponsor:   Medy-Tox
Not yet recruiting - verified April 2016

Pre-Diabetes Cardiovascular Care (Pre-Diabetes Wizard)

Condition:   Pre-diabetes
Intervention:   Other: Clinical Decision Support
Sponsors:   HealthPartners Institute;   Essentia Health
Not yet recruiting - verified April 2016

Quantification of Endothelial Thrombogenicity in Patients With Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Other: blood samples
Sponsor:   Hospices Civils de Lyon
Recruiting - verified April 2016

Clinical Applicability of Robot-assisted Gait Training System in Acute Stroke Patients

Condition:   Stroke
Interventions:   Device: HIWIN Robotic Gait Training System;   Other: Static Standing Table
Sponsor:   China Medical University Hospital
Not yet recruiting - verified April 2016

Prognosis of a First-Ever Stroke in Persons Living With HIV

Conditions:   Cerebrovascular Accident, Acute;   HIV
Intervention:   Other: stroke center referral
Sponsor:   Fondation Ophtalmologique Adolphe de Rothschild
Recruiting - verified April 2016

Intention to Prescribe/Take OAC Depending on the Number of Risk Diagrams , and Period for the Estimation of the Risk.

Conditions:   Atrial Fibrillation;   Stroke
Intervention:   Other: decision aid
Sponsor:   Cristian Baicus
Recruiting - verified April 2016

Laughter Therapy Effects on Mood, Stress and Self-efficacy in People With Neurological Diseases.

Conditions:   Alzheimer's Disease;   Amyotrophic Lateral Sclerosis;   Brain Injury;   Huntington's Disease;   Multiple Sclerosis;   Parkinson's Disease;   Stroke;   Spinal Cord Injury
Intervention:   Other: Laughter Therapy
Sponsor:   Brown, Theodore R., M.D., MPH
Not yet recruiting - verified April 2016

Clinical Study of Medicinal Product Cardionat® Using in Health Athlete Volunteers

Conditions:   Stroke, Not Specified as Hemorrhage or Infarction;   Angina Pectoris
Intervention:   Drug: оral intake of study drug capsules; study drug - Cardionat ® (trimethylhydrazinium propionate dihydrate), oral capsules 250 mg
Sponsor:   Burnasyan Federal Medical Biophysical Center
Recruiting - verified April 2016

Transplantation Using Reduced Intensity Approach for Patients With Sickle Cell Disease From Mismatched Family Donors of Bone Marrow

Condition:   Sickle Cell Disease
Interventions:   Procedure: Bone Marrow Transplant (BMT);   Procedure: Bone Marrow Harvest (Donation);   Drug: Hydroxyurea;   Drug: Thiotepa;   Drug: Fludarabine monophosphate;   Drug: Cyclophosphamide;   Other: Rabbit Anti-thymocyte Globulin;   Radiation: Total Body Irradiation
Sponsor:   Emory University
Recruiting - verified April 2016

Thrombolytic Care During Inter-hospital Transfer

Condition:   Stroke
Intervention:   Drug: Tissue Plasminogen Activator
Sponsor:   University of Iowa
Recruiting - verified April 2016

Early Independent Adaptive Arm and Hand Rehab

Condition:   Post-stroke Hemiparesis
Interventions:   Other: Conventional Occupational Therapy (OT);   Device: m2 BAT
Sponsor:   New York University School of Medicine
Not yet recruiting - verified April 2016

Telemedicine Monitoring of Sleep Apnea in Stroke

Conditions:   Stroke;   Sleep Apnea
Intervention:   Device: Auto CPAP AirSense™ 10(Resmed)
Sponsor:   Neurologisches Rehabiliationszentrum Rosenhügel
Recruiting - verified April 2016

Effects of Vitamin D and Fish Oil on the Kidney in Hypertensives

Conditions:   Hypertension;   Kidney Diseases
Interventions:   Dietary Supplement: Vitamin D3;   Drug: Omega-3 Fatty acids;   Dietary Supplement: Vitamin D3 placebo;   Dietary Supplement: Fish oil placebo
Sponsors:   Albert Einstein College of Medicine of Yeshiva University;   Brigham and Women's Hospital;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Enrolling by invitation - verified April 2016

International Intracranial Dissection Study

Conditions:   Cerebrovascular Disorders;   Vascular: Intracranial;   Intimal Dissection;   Stroke
Intervention:   Other: No study-specific intervention
Sponsors:   University Hospital Inselspital, Berne;   Swiss Heart Foundation;   Cervical Artery Dissections and Ischemic Stroke Patients - Consortium
Not yet recruiting - verified April 2016

Reduction to Preventive Doses of Enoxaparin After 3 to 6 Months of Treatment With Blood Thinners for Cancer-associated Blood Clots

Condition:   Deep Vein Thrombosis
Intervention:  
Sponsors:   Dr. Vicky Tagalakis;   Sanofi
Not yet recruiting - verified April 2016

Neurologic Injury Following Aortic Arch Replacement

Conditions:   Aortic Arch Replacement;   Hemi Arch Replacement
Interventions:   Procedure: DHCA+RCP;   Procedure: MHCA + SACP
Sponsor:   Emory University
Recruiting - verified April 2016

A Study to Assess Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)

Condition:   Duchenne Muscular Dystrophy
Interventions:   Drug: Vamorolone 1.0mg/kg/day;   Drug: Vamorolone 2.0mg/kg/day;   Drug: Vamorolone 4.0mg/kg/day;   Drug: Vamorolone 8.0mg/kg/day
Sponsors:   University of Pittsburgh;   ReveraGen BioPharma, Inc.;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS);   National Institute of Neurological Disorders and Stroke (NINDS);   Cooperative International Neuromuscular Research Group
Not yet recruiting - verified April 2016

An Extension Study to Assess Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)

Condition:   Duchenne Muscular Dystrophy
Interventions:   Drug: Vamorolone 1.0mg/day/day;   Drug: Vamorolone 2.0mg/day/day;   Drug: Vamorolone 4.0mg/day/day;   Drug: Vamorolone 8.0mg/day/day
Sponsors:   University of Pittsburgh;   ReveraGen BioPharma, Inc.;   National Institute of Neurological Disorders and Stroke (NINDS);   Cooperative International Neuromuscular Research Group;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Not yet recruiting - verified April 2016

Comparative Hybrid Effects of Combining BoNT-A With Robot-assisted or Mirror Therapy for U/E Spasticity Stroke Patients

Condition:   Stroke
Interventions:   Drug: Botulinum Toxin Type A;   Other: Robot-assisted therapy;   Other: Mirror therapy;   Other: Control intervention
Sponsor:   Chang Gung Memorial Hospital
Active, not recruiting - verified February 2016

Contrast Enhanced SWI for Carotid Plaque Imaging

Condition:   Carotid Plaque Imaging
Intervention:   Other: Methods of carotid wall imaging
Sponsor:   Seoul St. Mary's Hospital
Not yet recruiting - verified April 2016

Evaluation of Plasma Non-coding RNAs as Biomarkers in Coronary Heart Disease

Condition:   Coronary Disease
Intervention:   Other: No intervention
Sponsor:   Tongji Hospital
Not yet recruiting - verified April 2016

Defining a PD-specific Breath Fingerprint of Underlying Inflammatory and Neurodegenerative Processes

Condition:   Parkinson's Disease
Interventions:   Other: Blood Sample Collection;   Other: Breath Sample Collection
Sponsors:   Emory University;   Michael J. Fox Foundation for Parkinson's Research
Recruiting - verified April 2016

Dedicated Ambulator-assisted Physical Activity to Improve Hospital Outcome Measures in Elderly Patients

Conditions:   Weakness;   Hospital Acquired Condition
Intervention:   Other: Ambulation
Sponsor:   The Cleveland Clinic
Not yet recruiting - verified April 2016

Catheter Ablation Versus Thoracoscopic Surgical Ablation in Long Standing Persistent Atrial Fibrillation (CASA-AF)

Condition:   Persistent Atrial Fibrillation
Interventions:   Procedure: Thoracoscopic Surgical ablation;   Procedure: Catheter ablation
Sponsors:   Royal Brompton & Harefield NHS Foundation Trust;   National Institute for Health Research, United Kingdom;   Liverpool Heart and Chest Hospital NHS Foundation Trust
Recruiting - verified April 2016

Ischemic Stroke in Chinese Young Adults

Condition:   Ischemic Stroke
Intervention:   Biological: Ischemic Stroke
Sponsor:   Beijing Chao Yang Hospital
Not yet recruiting - verified April 2016

Carotid Atherosclerosis : Innovative Imaging Biomarkers. Study Case-control

Condition:   Carotid Stenosis
Intervention:   Device: HITS quantification, Ultrasound examinations, High Resolution MRI
Sponsors:   Hospices Civils de Lyon;   Fondation de France;   Bracco Imaging S.p.A.
Not yet recruiting - verified April 2016

The Effect of Nurse Practitioner Led-Care on Quality of Life in Patients With Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Other: Nurse Practitioner Led-Care;   Other: Cardiologist Led-Care
Sponsor:   University of Alberta
Not yet recruiting - verified April 2016

Effects of Induced Moderate HYPOthermia on Mortality in Cardiogenic Shock Patients Rescued by Veno-arterial ExtraCorporeal Membrane Oxygenation (ECMO)

Condition:   Cardiogenic Shock
Intervention:   Other: moderate hypothermia
Sponsor:   Central Hospital, Nancy, France
Not yet recruiting - verified April 2016

The Role of Values, Acceptance, and Mindfulness Strategies in Long Term Weight Management

Condition:   Obesity
Intervention:   Behavioral: Acceptance and Commitment Therapy
Sponsor:   Nova Scotia Health Authority
Not yet recruiting - verified April 2016

Effects of Cryotherapy on Ankle Movements and Gait of Spastic Hemiparetic Subjects

Conditions:   Stroke;   Muscle Spasticity
Interventions:   Other: Cryotherapy;   Other: Placebo
Sponsor:   Carolina Carmona de Alcântara
Recruiting - verified April 2016

An fMRI Study of the Efficacy and Safety of Jianpi Yishen Huatan Granules for Cognitive Impairment After Acute Cerebral Infarction

Condition:   Cognitive Impairment
Interventions:   Drug: Jianpi Yishen Huatan Granules;   Other: basic treatment
Sponsor:   Dongfang Hospital Affiliated to Beijing University of Chinese Medicine
Recruiting - verified April 2016

Systematic NT-proBNP and ECG Screening for Atrial Fibrillation Among 75 Year Old Subjects in the Region of Stockholm, Sweden - STROKESTOP II

Conditions:   Atrial Fibrillation;   Stroke
Intervention:   Other: ECG screening for atrial fibrillation
Sponsors:   Karolinska University Hospital;   Zenicor Medical Systems
Not yet recruiting - verified April 2016

Comparison of Standard CDT vs. USAT for Patients With Acute Submassive PE

Condition:   Pulmonary Embolism
Interventions:   Procedure: CDT without ultrasound acceleration;   Procedure: CDT with ultrasound acceleration
Sponsor:   University of Pittsburgh
Not yet recruiting - verified May 2016

Aerobic Dance Training in Small Vessel Disease

Condition:   Cerebrovascular Disease
Interventions:   Behavioral: Structured Aerobic Dance Training Group;   Behavioral: Stretching plus education
Sponsors:   Chinese University of Hong Kong;   The Hong Kong Polytechnic University
Not yet recruiting - verified April 2016

ShenFu Injection for Myocardial Protection in Patients With Acute ST Segment Elevation Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Drug: Shenfu Injection;   Drug: 5% Glucose Injection
Sponsors:   Beijing Anzhen Hospital;   China Resources Sanjiu Medical & Pharmaceutical Co., Ltd.
Recruiting - verified April 2016

Cerebral Hemodynamics in Sleep Disorders

Condition:   Sleep Disorders, Intrinsic
Intervention:  
Sponsor:   Yi Yang
Not yet recruiting - verified April 2016

Study of the Relationship Between Body Composition, Insulin Resistance and HDL Levels

Conditions:   Obesity;   Insulin Resistance
Intervention:   Drug: Heparin
Sponsors:   University of California, Davis;   Dialysis Clinic, Inc.
Enrolling by invitation - verified April 2016

Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy With Ex Vivo Generated Polyomavirus-Specific T-Cells

Condition:   Leukoencephalopathy
Interventions:   Biological: PyVST;   Other: No Intervention
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2016

A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Not yet recruiting - verified May 2016

Cholinergic Receptor Imaging in Dystonia

Conditions:   Cervical Dystonia;   Dystonia;   Movement Disorder;   Focal Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2016

Safety and Efficacy Study of a Protease Activated Receptor-4 Antagonist Being Tested to Reduce the Chances of Having Additional Strokes or "Mini Strokes"

Condition:   Thrombosis
Interventions:   Drug: BMS-986141;   Drug: Aspirin;   Other: Placebo
Sponsor:   Bristol-Myers Squibb
Not yet recruiting - verified January 2016

The PARTNER II Trial: S3iCAP

Condition:   Aortic Stenosis
Intervention:   Device: TAVR with SAPIEN S3 valve
Sponsor:   Edwards Lifesciences
Recruiting - verified February 2016

A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Advanced Prostate Cancer and Cardiovascular Disease

Condition:   Prostate Cancer
Interventions:   Drug: Degarelix;   Drug: Leuprolide
Sponsors:   Ferring Pharmaceuticals;   Memorial Sloan Kettering Cancer Center;   Duke Clinical Research Institute
Recruiting - verified April 2016

Evaluation of the Roadsaver Stent Used in Conjunction With the Nanoparasol Embolic Protection System for Carotid Artery Stenosis

Condition:   Carotid Artery Stenosis
Interventions:   Device: Roadsaver™ Carotid Artery Stent Device;   Device: Nanoparasol® Embolic Protection System
Sponsor:   Microvention-Terumo, Inc.
Recruiting - verified April 2016

Electric Impedance Tomography

Condition:   Stroke Volume
Intervention:   Device: Stroke Volume estimation using electrical impedance tomography
Sponsors:   Centre Suisse d'Electronique et Microtechnique SA;   Centre Hospitalier Universitaire Vaudois
Recruiting - verified May 2016

Erigo®Pro Coma Outcome Study - Study on the Effectiveness of a Robotic Tilt Table Device for Recovery of Consciousness

Conditions:   Brain Injuries;   Disorders of Consciousness
Interventions:   Behavioral: Standard physiotherapy;   Device: Erigo®Pro group without FES;   Device: Erigo®Pro group with FES
Sponsors:   Ludwig-Maximilians - University of Munich;   Therapiezentrum Burgau
Recruiting - verified April 2016

Patient Convenience Study (RE-SONANCE)

Conditions:   Atrial Fibrillation;   Stroke
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2016

Communicating Multiple Disease Risks

Condition:   Healthy
Interventions:   Behavioral: Cognitive interview;   Other: Survey
Sponsor:   Washington University School of Medicine
Suspended - verified May 2016

Open-Label and Single-Arm Study of MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adults

Condition:   Sialorrhea
Intervention:   Drug: MYOBLOC
Sponsor:   US WorldMeds LLC
Recruiting - verified April 2016

Randomized Trial of COBRA PzF Stenting to Reduce Duration of Triple Therapy

Conditions:   Angina, Stable;   Angina, Unstable;   Anticoagulants
Interventions:   Device: COBRA PzF;   Device: DES
Sponsor:   CeloNova BioSciences, Inc.
Recruiting - verified April 2016

A Cross-sectional Study for the Determination of the Prevalence of Non-valvular Atrial Fibrillation Among Patients Diagnosed With Hypertension

Conditions:   Hypertension;   Atrial Fibrillation
Intervention:   Other: Standard of care
Sponsor:   Bayer
Active, not recruiting - verified April 2016

Sleep Deficiency and Stroke Outcome

Conditions:   Sleep Apnea Syndromes;   Sleep Initiation and Maintenance Disorders;   Insomnia;   Restless Legs Syndrome;   Stroke
Intervention:  
Sponsors:   University Hospital Inselspital, Berne;   Neurocenter of Southern Switzerland;   Swiss Heart Foundation
Recruiting - verified April 2016

Investigation of Intravenous Tranexamic Acid With Anatomic and Reverse Total Shoulder Arthroplasty

Conditions:   Blood Loss;   Anatomic Total Shoulder Arthroplasty;   Reverse Total Shoulder Arthroplasty;   Transfusion;   Tranexamic Acid
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsor:   Rush University Medical Center
Recruiting - verified April 2016

Effect of Robot-assisted Gait Training on Brain Reorganization in Hemiplegic Patients

Condition:   Stroke
Intervention:   Device: Walkbot
Sponsor:   Veterans Health Service Medical Center, Seoul, Korea
Completed - verified April 2016

Safety of PZ-128 in Subjects Undergoing Non-Emergent Percutaneous Coronary Intervention

Conditions:   Arterial Occlusive Diseases;   Coronary Artery Disease;   Coronary Disease;   Arteriosclerosis;   Heart Diseases;   Myocardial Ischemia;   Vascular Diseases;   Acute Coronary Syndrome
Interventions:   Drug: PZ-128;   Drug: Placebo
Sponsors:   Tufts Medical Center;   National Heart, Lung, and Blood Institute (NHLBI);   RTI International;   Inova Fairfax Hospital;   University of Massachusetts, Worcester
Recruiting - verified May 2016

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified April 2016

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified April 2016

GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Type IV Thoracoabdominal Aortic Aneurysms Involving the Visceral Branch Vessels

Condition:   Thoracoabdominal Aortic Aneurysm
Intervention:   Device: GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis
Sponsor:   W.L.Gore & Associates
Recruiting - verified April 2016

aMAZE Study: LAA Ligation Adjunctive to PVI for Persistent or Longstanding Persistent Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Device: LARIAT + PVI;   Device: Pulmonary Vein Isolation
Sponsor:   SentreHEART, Inc.
Recruiting - verified April 2016

Phase IV O2 Consumption Study in COPD Patients

Condition:   Chronic Obstructive Pulmonary Disease (COPD)
Interventions:   Drug: Budesonide 160 mcg and formoterol fumarate dehydrate 4.5 mcg Inhalation aerosol;   Drug: Matching Placebo pMDI 160/4.5 μg
Sponsor:   AstraZeneca
Recruiting - verified April 2016

Validation of Nicom Device to Measure Stoke Volume Variation

Condition:   Anesthesia
Interventions:   Procedure: Volume loading;   Drug: Ringer solution
Sponsor:   Hopital Foch
Recruiting - verified April 2016

Early Sleeve Gastrectomy In New Onset Diabetic Obese Patients

Condition:   Type 2 Diabetes Mellitus
Interventions:   Procedure: LSG;   Drug: CMT
Sponsors:   Azienda Ospedaliera Santa Maria, Terni, Italy;   Ethicon Endo-Surgery
Recruiting - verified April 2016

Aspirin Twice a Day in Patients With Diabetes and Acute Coronary Syndrome

Conditions:   Diabetes Mellitus;   Acute Coronary Syndrome;   Coronary Artery Disease
Interventions:   Drug: Novel strategy Aspirin;   Drug: Conventional strategy Aspirin
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Bayer
Not yet recruiting - verified April 2016

The Aortic Surgery Cerebral Protection Evaluation (ACE) Randomized Trial

Condition:   Aortic Aneurysm, Thoracic
Interventions:   Procedure: Axillary artery cannulation;   Procedure: Innominate artery cannulation
Sponsors:   St. Michael's Hospital, Toronto;   London Health Sciences Centre
Recruiting - verified April 2016

Study of Modified Stem Cells (SB623) in Patients With Chronic Motor Deficit From Ischemic Stroke

Condition:   Chronic Ischemic Stroke
Interventions:   Biological: SB623 Implant (2.5M);   Biological: SB623 Implant (5.0M);   Procedure: Sham surgery
Sponsors:   SanBio, Inc.;   Sunovion
Recruiting - verified April 2016

Using Telmisartan With ART During Acute HIV Infection to Reduce the CNS Reservoirs of HIV and Lymph Node Fibrosis

Conditions:   Acute HIV Infection;   HIV CNS Involvement
Interventions:   Drug: TDF/3TC/EFV + Telmisartan;   Drug: TDF/3TC/EFV only
Sponsors:   South East Asia Research Collaboration with Hawaii;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2016

Profile and Antithrombotic Management of Patients With NVAF Attending Internal Medicine Departments in Spain (PERFILAR Study)

Condition:   Anticoagulation, Blood Thinners , Atrial Fibrillation, Bleeding, Stroke
Intervention:  
Sponsor:   Bristol-Myers Squibb
Active, not recruiting - verified May 2016

Study of Compound Edaravone Injection for Treatment of Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke
Interventions:   Drug: Compound Edaravone Injection;   Drug: Edaravone Injection
Sponsor:   Jiangsu Simcere Pharmaceutical Co., Ltd.
Active, not recruiting - verified April 2016

Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure

Conditions:   Orthostatic Hypotension;   Pure Autonomic Failure;   Multiple System Atrophy;   Autonomic Failure
Interventions:   Other: Abdominal compression;   Other: Sham abdominal compression;   Drug: Placebo pill;   Drug: midodrine
Sponsor:   Vanderbilt University
Recruiting - verified April 2016

Women's Health Initiative Strong and Healthy Study

Conditions:   Myocardial Infarction;   Stroke;   Cardiovascular Mortality;   Hip Fractures;   Falls;   Mortality;   Venous Thromboembolic Event;   Peripheral Artery Disease
Intervention:   Behavioral: Physical Activity
Sponsors:   Fred Hutchinson Cancer Research Center;   University of California, San Diego;   Stanford University;   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation - verified April 2016

Oral Guanabenz for Multiple Sclerosis

Conditions:   Multiple Sclerosis, Relapsing-Remitting;   Multiple Sclerosis
Intervention:   Drug: Guanabenz
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2016

A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart

Condition:   Acute Coronary Syndromes
Interventions:   Drug: Apixaban;   Drug: vitamin K antagonist;   Drug: Acetylsalicylic acid;   Other: Acetylsalicylic acid placebo
Sponsors:   Bristol-Myers Squibb;   Pfizer;   Duke Clinical Research Institute
Recruiting - verified April 2016

Evaluation of Valiant Mona LSA

Condition:   Aortic Aneurysm, Thoracic, Chronic Type B Dissection
Intervention:   Device: Valiant Mona LSA Thoracic Stent Graft System
Sponsor:   Medtronic Endovascular
Recruiting - verified April 2016

Combined Cognitive and Gait Training

Condition:   Stroke
Interventions:   Behavioral: Gait training;   Behavioral: cognitive training;   Behavioral: Arm training
Sponsor:   VA Office of Research and Development
Active, not recruiting - verified April 2016

Robot Aided Rehabilitation - Multi-point Evaluations

Condition:   Stroke
Intervention:  
Sponsors:   Rehabilitation Institute of Chicago;   U.S. Department of Education;   Illinois Institute of Technology;   Northwestern University
Recruiting - verified April 2016

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

Conditions:   FTLD;   Progressive Supranuclear Palsy (PSP);   Frontotemporal Dementia (FTD);   Corticobasal Degeneration (CBD);   PPA Syndrome;   Behavioral Variant Frontotemporal Dementia (bvFTD);   Semantic Variant Primary Progressive Aphasia (svPPA);   Nonfluent Variant Primary Progressive Aphasia (nfvPPA);   FTD With Amyotrophic Lateral Sclerosis (FTD/ALS);   Amyotrophic Lateral Sclerosis (ALS);   Oligosymptomatic PSP (oPSP);   Corticobasal Syndrome (CBS)
Intervention:  
Sponsors:   University of California, San Francisco;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   The Bluefield Project;   Tau Consortium
Recruiting - verified April 2016

Curative Efficacy of Secondary Prevention for Patients With Ischemic Stroke Through Syndrome Differentiation of TCM

Condition:   Ischemic Stroke
Interventions:   Drug: Naoxintong Capsule;   Drug: Placebo
Sponsors:   Xiaofei Yu;   Shanghai Municipal Science and Technology Commission
Recruiting - verified April 2016

Shockwave Coronary Lithoplasty Study

Condition:   Coronary Stenosis
Intervention:   Device: Shockwave Coronary Lithoplasty System
Sponsors:   Shockwave Medical, Inc.;   Yale Cardiovascular Research Group;   Massachusetts General Hospital;   Pacific Clinical Research Group
Completed - verified April 2016

Effect Of Early C-PAP Treatment For Sleep Apnea On Rehabilitation Of Stroke Patients

Conditions:   Sleep Apnea;   Stroke
Interventions:   Device: Watchpat;   Device: CPAP
Sponsor:   Soroka University Medical Center
Not yet recruiting - verified April 2016

Study to Assess Impact of Dysport Injections Early After Stroke on Upper Limb Spasticity Progression

Conditions:   Stroke;   Upper Limb Spasticity
Interventions:   Drug: BotulinumtoxinA;   Drug: Placebo
Sponsor:   Ipsen
Completed - verified April 2016

Mechanistic Study of Bleeding Risk in Coronary Patients With Cerebrovascular Disease

Conditions:   Coronary Artery Disease;   Cerebral Stroke;   TIA (Transient Ischemic Attack)
Intervention:  
Sponsors:   University of Sao Paulo General Hospital;   Fundação de Amparo à Pesquisa do Estado de São Paulo
Completed - verified June 2014

Effects of Low Molecular Weight Heparin Versus Dabigatran on Platelet Aggregation in Patients With Stable Coronary Artery Disease

Condition:   Coronary Disease
Interventions:   Drug: Dabigatran;   Drug: Enoxaparin
Sponsors:   University of Sao Paulo General Hospital;   Fundação de Amparo à Pesquisa do Estado de São Paulo
Completed - verified August 2014

"In Vivo" Comparison in Human Carotid Atherosclerosis: Plaque Neovascularization

Conditions:   Carotid Artery Disease;   Plaque Neovascularization
Interventions:   Other: Contrast enhanced ultrasound of the carotid plaque;   Other: Dynamic contrast-enhanced carotid plaque MRI
Sponsor:   Ospedale San Giovanni Bellinzona
Completed - verified April 2016

The Effect of Fluid Management by SVV of FloTrac/ Vigileo™ Monitoring on Postoperative Recovery in Bowel Resection

Condition:   Bowel Resection
Interventions:   Device: Conventional arterial blood pressure monitoring;   Device: Stroke volume variation monitoring with arterial blood pressure monitoring
Sponsor:   Yonsei University
Recruiting - verified April 2016

RuSsian RegisTry of Acute CoronaRy SyndromE TreAtMent and Approach in Dual Antiplatelet Therapy

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified April 2016

Paired Associative Stimulation in Post-stroke Hand Motor Deficits

Condition:   Stroke and Healthy Subjects
Intervention:   Device: PAS
Sponsor:   Institut National de la Santé Et de la Recherche Médicale, France
Recruiting - verified April 2016

ETREAT Study on Effectiveness of Botulinum Toxin Type A Injections to Treat Post-stroke Upper and/or Lower Limb Spasticity

Condition:   Spasticity
Intervention:  
Sponsor:   Ipsen
Recruiting - verified April 2016

Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability

Conditions:   Chronic Troublesome Sialorrhea;   Cerebral Palsy;   Stroke;   Traumatic Brain Injury;   Intellectual Disability
Interventions:   Drug: IncobotulinumtoxinA;   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Recruiting - verified April 2016

SMARTCap Stroke Study: A Field Deployable Blood Test for Stroke

Condition:   Stroke
Intervention:   Device: SMARTCap
Sponsor:   University Hospitals Coventry and Warwickshire NHS Trust
Completed - verified April 2016

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified April 2016

ArmeoSenso - Reward

Condition:   Stroke
Interventions:   Behavioral: high incentive;   Behavioral: low incentive
Sponsor:   Cereneo AG
Recruiting - verified April 2016

Electroacupuncture in Reducing the Dose of Analgesic in Patients Undergoing Off-pump Coronary Artery Bypass Grafting

Condition:   Coronary Disease
Interventions:   Device: TEAS(transcutaneous electric acupoint stimulation);   Device: TEAS (transcutaneous electric acupoint stimulation);   Device: TEAS (transcutaneous electric acupoint stimulation)
Sponsor:   Xijing Hospital
Completed - verified December 2015

A Registration Study for Dyslipidemia

Condition:   Atherosclerotic Vascular Diseases
Intervention:  
Sponsor:   National Taiwan University Hospital
Recruiting - verified April 2016

The Effects of tDCS Combined With Balance Training on Postural Control in Chronic Stroke Patients

Condition:   Ischemic Stroke
Interventions:   Device: Transcranial direct current stimulation (tDCS);   Device: Sham
Sponsor:   Shahid Beheshti University of Medical Sciences
Recruiting - verified November 2015

Neuroprotection of Pioglitazone in Acute Ischemic Stroke

Condition:   Stroke
Interventions:   Drug: Pioglitazone;   Drug: Placebo
Sponsor:   Taipei Medical University Shuang Ho Hospital
Recruiting - verified April 2016

Medtronic CoreValve Evolut R U.S. Clinical Study

Condition:   Aortic Stenosis
Intervention:   Device: CoreValve Evolut R TAVR system
Sponsor:   Medtronic Cardiovascular
Active, not recruiting - verified April 2016

Feasibility Study of Arterial Stiffness in Hemodialysis Patients

Condition:   End-Stage Renal Disease
Intervention:   Other: Applanation tonometry
Sponsors:   Ottawa Hospital Research Institute;   The Ottawa Hospital;   University of Ottawa
Terminated - verified March 2016

Refinement and Clinical Evaluation of the H-Man for Arm Rehabilitation After Stroke

Condition:   Stroke
Interventions:   Device: H-Man;   Other: Additional Conventional Therapy
Sponsors:   Tan Tock Seng Hospital;   National Medical Research Council (NMRC), Singapore
Recruiting - verified April 2016

Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis (MIRACULOUS) Trial

Condition:   Atherosclerosis
Interventions:   Drug: Eplerenone;   Drug: Placebo
Sponsor:   University of Maryland
Recruiting - verified April 2016

Transcatheter Aortic Valve Replacement System Pivotal Trial

Condition:   Aortic Valve Stenosis
Interventions:   Device: Direct Flow Medical;   Device: Commercially Available
Sponsor:   Direct Flow Medical, Inc.
Recruiting - verified April 2016

Early Post-marketing Study of Eliquis (Apixaban)

Condition:   Non-valvular Atrial Fibrillation (NVAF)
Intervention:   Drug: Apixaban
Sponsor:   Bristol-Myers Squibb
Active, not recruiting - verified July 2015

A Blinded Study to Evaluate Effect on Atrial Fibrillation Burden in Patients With Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Interventions:   Drug: BMS-919373;   Drug: Placebo (Matching with BMS-919373)
Sponsor:   Bristol-Myers Squibb
Recruiting - verified January 2016

A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients

Conditions:   Heart Failure;   Respiratory Insufficiency;   Stroke Acute;   Infectious Diseases;   Rheumatic Diseases
Interventions:   Drug: Rivaroxaban, 10 mg;   Drug: Rivaroxaban, 7.5 mg;   Drug: Placebo
Sponsor:   Janssen Research & Development, LLC
Recruiting - verified April 2016

Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes

Condition:   Diabetes Type 2
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified August 2015

Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions

Conditions:   Chronic Troublesome Sialorrhea;   Parkinson's Disease;   Post-stroke;   Traumatic Brain Injury
Interventions:   Drug: IncobotulinumtoxinA (100 Units);   Drug: IncobotulinumtoxinA (75 Units);   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Active, not recruiting - verified April 2016

Edoxaban vs. Warfarin in Subjects Undergoing Cardioversion of Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Drug: edoxaban;   Drug: Enoxaparin;   Drug: Warfarin
Sponsors:   Daiichi Sankyo Inc.;   Covance;   Quintiles, Inc.
Active, not recruiting - verified April 2016

Study Of The Blood Thinner, Apixaban, For Patients Who Have An Abnormal Heart Rhythm (Atrial Fibrillation) And Expected To Have Treatment To Put Them Back Into A Normal Heart Rhythm (Cardioversion)

Condition:   Atrial Fibrillation
Interventions:   Drug: Apixaban;   Drug: Parenteral heparin and/or oral Vitamin K antagonist
Sponsors:   Pfizer;   Bristol-Myers Squibb
Recruiting - verified April 2016

Accuracy of Pulse Pressure Variation and of Pleth Variability Index to Predict the Response to a Fluid Challenge

Condition:   Fluid Responsiveness
Intervention:   Device: - Nexfin (Pulse Pressure Variation) - Radical 7 (Pleth Variability Index) - CardioQ (stroke volume)
Sponsor:   Hopital Foch
Completed - verified April 2016

Vasodilator-induced Hypovolemia in Living Liver Donors

Conditions:   CVP and SVV During Living Donor Hepatectomy;   Surgical Field Grade (Condition of Surgical Field; Bleeding, Tension of the IVC)
Intervention:   Procedure: vasodilator induced hypovolemia
Sponsor:   Seoul National University Hospital
Completed - verified April 2016

RESPOND Post Market Study

Condition:   Aortic Stenosis.
Intervention:   Device: Lotus Valve System
Sponsor:   Boston Scientific Corporation
Active, not recruiting - verified May 2016

Individually Tailored Treatment of Type 2 Diabetes

Conditions:   Type 2 Diabetes;   Hypertension
Intervention:   Other: Individual treatment
Sponsors:   Odense University Hospital;   Region of Southern Denmark;   Hospital of South West Denmark;   General Practice Research Database
Enrolling by invitation - verified April 2016

Pilot Study for Automated Deep Brain Stimulation Programming

Conditions:   Parkinson's Disease;   Tremor;   Bradykinesia
Intervention:   Device: Automated Programming
Sponsors:   Great Lakes NeuroTechnologies Inc.;   National Institute of Neurological Disorders and Stroke (NINDS);   University of Cincinnati
Completed - verified April 2016

Rapid Exchange Devices Observational Registry.

Condition:   Peripheral (Lowr Extremity) Arterial Disease.
Intervention:  
Sponsor:   Terumo Europe N.V.
Active, not recruiting - verified April 2016

Efficacy and Safety Study of MYOBLOC® Followed by Open-Label Multiple-Treatment With MYOBLOC® in the Treatment of Troublesome Sialorrhea in Adult Subjects

Condition:   Sialorrhea
Interventions:   Drug: MYOBLOC;   Other: PLACEBO
Sponsor:   US WorldMeds LLC
Active, not recruiting - verified April 2016

The Synergistic Effect of Local Anesthetics on Hemodynamic Changes During the Application of Paravertebral Block

Conditions:   Breast Tumors;   Hypotension;   Bradycardia
Intervention:   Procedure: ultrasound guided paravertebral blocks in breast surgery
Sponsor:   University Hospital Dubrava
Active, not recruiting - verified April 2016

Evaluating Human-Machine Interfaces in a Robotic Thumb Orthosis

Conditions:   Hemiplegic Stroke;   Hemiplegic Cerebral Palsy
Intervention:   Device: Isolated Orthosis for Thumb Actuation (IOTA)
Sponsors:   Wyss Institute at Harvard University;   Children's Hospital Boston;   Deborah Munroe Noonan Memorial Research Fund
Active, not recruiting - verified April 2016

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified May 2016

Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Hyperlipidemia or Mixed Dyslipidemia at Risk of Cardiovascular Events

Condition:   Hyperlipidemia
Interventions:   Drug: Bococizumab (PF-04950615; RN316);   Other: Placebo
Sponsor:   Pfizer
Recruiting - verified April 2016

Comparision of Blood Pressure Variability Between Amlodipine and Losartan

Condition:   Hypertension
Interventions:   Drug: Amlodipine;   Drug: Losartan
Sponsors:   Wonju Severance Christian Hospital;   Pfizer
Recruiting - verified April 2016

Biomarkers and Perfusion - Training-Induced Changes After Stroke

Condition:   Stroke
Intervention:  
Sponsor:   Charite University, Berlin, Germany
Recruiting - verified April 2016

Robotic-assisted Gait Training Combined With Transcranial Direct Current Stimulation to Maximize Gait Recovery After Stroke

Condition:   Stroke
Interventions:   Device: tDCS;   Device: Robotic-assisted gait training
Sponsor:   Seoul National University Hospital
Recruiting - verified April 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Germany)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsor:   Bayer
Recruiting - verified April 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxoban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsor:   Bayer
Recruiting - verified April 2016

GLORIA-AF Registry Program (Phase II/III)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified April 2016

Risk of Stroke and Silent Cerebrovascular Thromboembolism After Cardioversion of Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Cardioversion;   Cerebrovascular Stroke
Interventions:   Procedure: Cardioversion;   Drug: warfarin
Sponsor:   Suleyman Demirel University
Recruiting - verified April 2016

Cognitive Oriented Strategy Training Augmented Rehabilitation (COSTAR) Treatment Approach for Stroke

Condition:   Stroke
Interventions:   Behavioral: Cognitive-Oriented Strategy Augmented Rehabilitation (COSTAR);   Behavioral: Task Specific Training (TST)
Sponsor:   Washington University School of Medicine
Completed - verified April 2016

Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Placebo;   Drug: Linagliptin
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified April 2016

The Medtronic CoreValve™ Evolut R™ CE Mark Clinical Study

Condition:   Aortic Stenosis
Intervention:   Device: The CoreValve™ Evolut R TAV™ system
Sponsors:   Medtronic Cardiovascular;   Medtronic
Active, not recruiting - verified April 2016

Flow MRI in Normal Pressure Hydrocephalus

Condition:   Normal Pressure Hydrocephalus
Intervention:   Other: Flow imaging
Sponsor:   Centre Hospitalier Universitaire, Amiens
Recruiting - verified April 2016

Safety and Efficacy Study of Etanercept for Aneurysmal Subarachnoid Hemorrhage

Condition:   Subarachnoid Hemorrhage, Aneurysmal
Intervention:   Drug: Etanercept
Sponsor:   St. Michael's Hospital, Toronto
Not yet recruiting - verified May 2016

Comparison of Different Treatment Methods for Gait Rehabilitation of Sub-Acute Post Stroke Patients With Dropped Foot

Condition:   Dropped Foot
Intervention:   Device: FES
Sponsor:   Hadassah Medical Organization
Recruiting - verified April 2013

Pediatric Autologous Bone Marrow Mononuclear Cells for Severe Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Interventions:   Biological: autologous bone marrow mononuclear cells;   Other: Placebo Infusion
Sponsors:   The University of Texas Health Science Center, Houston;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2016

Study of Procoagulation Markers in Stroke Patients

Conditions:   Stroke;   Hyperglycemia;   Procoagulation Markers
Intervention:   Other: Glycemic Control
Sponsors:   Temple University;   National Institute of Neurological Disorders and Stroke (NINDS);   Neurological Emergencies Treatment Trials Network (NETT);   University of Virginia;   University of Michigan;   Medical University of South Carolina;   Georgia Regents University
Recruiting - verified April 2016

Satisfaction/Quality of Life With Rivaroxaban in SPAF (Stroke Prevention in Atrial Fibrillation) Indication

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsor:   Bayer
Completed - verified April 2016

Prehospital Cerebral Oxygenation During Cardiopulmonary Resuscitation (CPR)

Condition:   Cardiac Arrest
Intervention:  
Sponsors:   Hasselt University;   Ziekenhuis Oost-Limburg
Completed - verified April 2016

Traumatic Optic Neuropathy Treatment Trial (TONTT)

Condition:   Traumatic Optic Neuropathy
Intervention:   Drug: Recombinant human erythropoietin (EPO)
Sponsors:   Tehran University of Medical Sciences;   Iran University of Medical Sciences;   Mashhad University of Medical Sciences;   Shahid Beheshti University of Medical Sciences
Recruiting - verified April 2016

Clinical Effectiveness of Self-Management Education Post-Mild Stroke

Conditions:   Stroke;   Chronic Disease
Intervention:   Behavioral: Chronic Disease Self-Management Program (CDSMP)
Sponsor:   Washington University School of Medicine
Completed - verified April 2016

COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure.

Conditions:   Modified Release Oral Formulation;   Left Ventricular Systolic Dysfunction;   Chronic Heart Failure;   History of Chronic Heart Failure;   Left Ventricular Ejection Fraction;   Pharmacokinetics;   Echocardiogram
Interventions:   Drug: Omecamtiv mecarbil;   Drug: Omecamtiv mecarbil;   Drug: Placebo;   Drug: Omecamtiv Mecarbil;   Drug: Omecamtiv Mecarbil
Sponsors:   Amgen;   Cytokinetics
Completed - verified April 2016

Modifiers of Disease Severity in Cerebral Cavernous Malformations

Conditions:   Cavernous Angioma, Familial;   Cerebral Cavernous Malformations;   Cerebral Cavernous Hemangioma
Intervention:  
Sponsors:   University of New Mexico;   University of California, San Francisco;   Barrow Neurological Institute;   Angioma Alliance;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016

The Diagnosis and Treatment of Resistant Hypertension, the Prevalence and the Prognosis

Condition:   Hypertension, Resistant to Conventional Therapy
Intervention:  
Sponsors:   Chinese Academy of Medical Sciences, Fuwai Hospital;   Huazhong University of Science and Technology;   Shanghai Jiao Tong University School of Medicine
Active, not recruiting - verified April 2016

Safety & Efficacy Study of the Medtronic CoreValve® System-Treatment of Symptomatic Severe Aortic Stenosis With Significant Comorbidities in Very High Risk Subjects Who Need Aortic Valve Replacement

Condition:   Severe Aortic Stenosis
Intervention:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting - verified April 2016

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab;   Drug: placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified April 2016

Vitamin D and Omega-3 Hypertension Trial (VITAL Hypertension)

Condition:   Hypertension
Interventions:   Dietary Supplement: Vitamin D-3 (cholecalciferol), 2000 IU;   Drug: Omega-3 fatty acids (fish oil);   Dietary Supplement: Vitamin D placebo;   Drug: Fish oil placebo
Sponsors:   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified April 2016

Thrombus Aspiration in ThrOmbus Containing culpRiT Lesions in Non-ST-Elevation Myocardial Infarction (TATORT-NSTEMI)

Condition:   Non-ST-elevation Myocardial Infarction
Interventions:   Procedure: Thrombectomy;   Procedure: Standard percutaneous coronary intervention
Sponsor:   University of Leipzig
Active, not recruiting - verified April 2016

Cardiovascular Outcomes Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects With Cardiovascular Risk Factors (The Light Study)

Conditions:   Obesity;   Overweight
Interventions:   Drug: NB32;   Drug: PBO;   Behavioral: Weight Management Program
Sponsor:   Orexigen Therapeutics, Inc
Terminated - verified April 2016

Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI).

Condition:   Severe Aortic Stenosis
Interventions:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI);   Procedure: Surgical Aortic Valve Replacement (SAVR);   Device: Medtronic CoreValve® Evolut R System Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Medtronic Cardiovascular
Recruiting - verified April 2016

Brain Stimulation-aided Stroke Rehabilitation: Neural Mechanisms of Recovery

Condition:   Stroke
Interventions:   Procedure: tDCS: noninvasive brain stimulation;   Behavioral: Constraint induced movement therapy (CIMT);   Procedure: Sham tDCS: placebo noninvasive brain stimulation
Sponsors:   The Cleveland Clinic;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified April 2016

Safety and Efficacy Continued Access Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in Very High Risk Subjects and High Risk Subjects Who Need Aortic Valve Replacement

Condition:   Severe Aortic Stenosis
Intervention:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting - verified April 2016

Active MOBility Early After Stroke : What Should be the Best Physiotherapy Early After Stroke ?

Condition:   Rehabilitation
Interventions:   Procedure: standard physiotherapy;   Procedure: experimental physiotherapy
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Ministry of Health, France
Completed - verified April 2016

Buspirone Therapy for Localized Epilepsy

Conditions:   Anxiety Disorder;   Seizures;   Epilepsy;   Partial Epilepsy;   Depression
Intervention:   Drug: Buspirone
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified April 2016

Analysis of Visual-Motor Task Electrophysiological Activity During Deep Brain Stimulation for Treatment-Resistant Movement Disorders

Condition:   Obsessive-Complusive Disorder
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   George Washington University
Recruiting - verified April 2016

A Open-Label Study Of CP-690,550 As Long-Term Therapy (48 Weeks) In Subjects With Crohn's Disease

Condition:   Crohn's Disease
Interventions:   Drug: CP-690,550;   Drug: CP-690,550
Sponsor:   Pfizer
Recruiting - verified April 2016

Assessing Special Features of Impaired Gait After Acquired Brain Injury With an Instrumented Treadmill

Condition:   Traumatic and/or Non-traumatic Brain Injury
Intervention:  
Sponsor:   Sheba Medical Center
Recruiting - verified April 2016

Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial

Conditions:   Acute Ischemic Stroke;   Diabetes;   Hyperglycemia
Interventions:   Drug: IV insulin to maintain target glucose concentration of 80-130 mg/dL;   Drug: Standard Care control - sliding scale insulin to keep glucose less than 180 mg/dL
Sponsors:   University of Virginia;   Neurological Emergencies Treatment Trials Network (NETT);   Medical University of South Carolina;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 2014

Evaluation of Therapeutic Hypothermia in Convulsive Status EPILEPTICUS in Adults in Intensive Care

Condition:   Convulsive Status EPILEPTICUS
Intervention:   Procedure: Moderate hypothermia
Sponsor:   Assistance Publique - Hôpitaux de Paris
Active, not recruiting - verified September 2015

Manganese-Enhanced Magnetic Resonance Imaging in Healthy Volunteers and People With Multiple Sclerosis

Conditions:   Multiple Sclerosis;   Optic Neuritis
Intervention:   Drug: Mangafodipir (Teslascan)
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified June 2015

Post-stroke Cognitive Impairment and Dementia

Conditions:   Stroke;   Cognitive Disorders;   Behavioral Disorders
Intervention:   Behavioral: French adaptation of NINDS-Canadian Stroke Network battery
Sponsor:   Centre Hospitalier Universitaire, Amiens
Recruiting - verified April 2016

Antihypertensive Treatment of Acute Cerebral Hemorrhage-II

Condition:   Intracerebral Hemorrhage
Intervention:   Drug: Nicardipine hydrochloride
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   National Institute of Neurological Disorders and Stroke (NINDS);   Medical University of South Carolina;   Johns Hopkins University;   University of Michigan
Completed - verified April 2016

Evaluation of Routine Follow-up Coronary Angiography After Percutaneous Coronary Intervention Trial

Condition:   Coronary Artery Disease
Interventions:   Procedure: follow-up coronary angiography;   Procedure: Clinical follow-up
Sponsor:   Takeshi Morimoto
Active, not recruiting - verified April 2016

Top-Down Attentional Control of Visual-Processing

Conditions:   Focal Brain Lesion;   Focal Lesions;   fMRI
Intervention:  
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting - verified July 2015

The Nordic Aortic Valve Intervention Trial

Condition:   Critical Aortic Stenosis
Interventions:   Procedure: Transcatheter Aortic Valve Implantation;   Procedure: Surgical Aortic Valve Replacement
Sponsors:   Rigshospitalet, Denmark;   Odense University Hospital;   Sahlgrenska University Hospital, Sweden;   Danish Heart Foundation;   Copenhagen Trial Unit, Center for Clinical Intervention Research
Active, not recruiting - verified April 2016

Cognitive Dysfunction After Aneurysmal Subarachnoid Haemorrhage

Condition:   Cognitive Dysfunction
Intervention:   Other: Cognitive assessment
Sponsor:   Chinese University of Hong Kong
Recruiting - verified April 2016

Screening Protocol for Patients With Stroke

Condition:   Stroke
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2016

Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors

Conditions:   Adult Central Nervous System Germ Cell Tumor;   Adult Ependymoblastoma;   Adult Medulloblastoma;   Adult Pineoblastoma;   Adult Supratentorial Primitive Neuroectodermal Tumor;   Childhood Atypical Teratoid/Rhabdoid Tumor;   Childhood Central Nervous System Germ Cell Tumor;   Childhood Ependymoblastoma;   Medulloepithelioma;   Ototoxicity;   Recurrent Adult Brain Neoplasm;   Recurrent Childhood Central Nervous System Embryonal Neoplasm;   Recurrent Childhood Malignant Germ Cell Tumor;   Recurrent Childhood Medulloblastoma;   Recurrent Childhood Pineoblastoma;   Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor
Interventions:   Drug: Carboplatin;   Drug: Mannitol;   Drug: Melphalan;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Drug: Sodium Thiosulfate
Sponsors:   OHSU Knight Cancer Institute;   National Cancer Institute (NCI);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2016

Catheter Ablation vs Anti-arrhythmic Drug Therapy for Atrial Fibrillation Trial

Conditions:   Atrial Fibrillation;   Arrhythmia
Interventions:   Device: Left atrial ablation;   Drug: Rate or Rhythm Control Therapy
Sponsors:   Mayo Clinic;   National Heart, Lung, and Blood Institute (NHLBI);   St. Jude Medical;   Biosense Webster, Inc.
Active, not recruiting - verified April 2016

Clarification of Optimal Anticoagulation Through Genetics

Conditions:   Stroke;   Venous Thrombosis;   Atrial Fibrillation;   Atrial Flutter
Interventions:   Behavioral: Genotype-guided dosing algorithm for warfarin;   Behavioral: Clinical-guided dosing algorithm for warfarin
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   Bristol-Myers Squibb
Completed - verified May 2013

Protein S100 Beta as a Predictor of Resuscitation Outcome

Condition:   Cardiopulmonary Arrest Outcome
Intervention:  
Sponsor:   Shaare Zedek Medical Center
Active, not recruiting - verified April 2016

GORE® HELEX® Septal Occluder / GORE® Septal Occluder for Patent Foramen Ovale (PFO) Closure in Stroke Patients - The Gore REDUCE Clinical Study

Conditions:   Stroke;   Transient Ischemic Attack
Interventions:   Device: GORE® HELEX® Septal Occluder / GORE® Septal Occluder;   Other: Antiplatelet Medical Therapy
Sponsor:   W.L.Gore & Associates
Active, not recruiting - verified April 2016

The Melatonin Adjunct in the Acute myocaRdial Infarction Treated With Angioplasty

Condition:   Acute Myocardial Infarction
Intervention:   Drug: melatonin
Sponsor:   Alberto Dominguez-Rodriguez, MD, PhD, FESC
Active, not recruiting - verified April 2016

Insulin Resistance and Atherosclerosis in Women With Lupus

Conditions:   Systemic Lupus Erythematosus;   Insulin Resistance;   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Completed - verified April 2016

RESPECT PFO Clinical Trial

Condition:   Cryptogenic Stroke
Interventions:   Device: AMPLATZER PFO Occluder;   Other: Standard of Care - Medical Management
Sponsor:   St. Jude Medical
Active, not recruiting - verified May 2016

Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System

Condition:   Healthy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2016

hsCRP in Japan Statin Treatment Against Recurrent Stroke (J-STARS hsCRP)

Condition:   Ischemic Stroke
Intervention:   Drug: Statin
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Ministry of Health, Labour and Welfare, Japan;   Hiroshima University;   Osaka University
Completed - verified April 2016

Carotid Intima-media Thickness in Japan Statin Treatment Against Recurrent Stroke(J-STARS Echo)

Condition:   Ischemic Stroke
Intervention:   Drug: Statin
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Ministry of Health, Labour and Welfare, Japan;   Hiroshima University;   National Cerebral and Cardiovascular Center
Completed - verified April 2016

Vision Testing in Patients With Partial Seizures Receiving Either Lyrica or Placebo

Condition:   Epilepsies, Partial
Interventions:   Drug: Lyrica (pregabalin);   Drug: placebo
Sponsor:   Pfizer
Recruiting - verified April 2016

Japan Statin Treatment Against Recurrent Stroke (J-STARS)

Condition:   Ischemic Stroke
Intervention:   Drug: Pravastatin
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Ministry of Health, Labour and Welfare, Japan;   Hiroshima University
Completed - verified March 2015