Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Involvement of the Physician in Primary Prevention and Pre-hospital Management of Stroke

Condition:   Stroke
Intervention:   Other: Patients With Stroke
Sponsor:   Groupe Hospitalier Paris Saint Joseph
Recruiting

Prediction Model for Recanalization Outcome Evaluation of Ischemic Stroke Using Multimodal CT

Condition:   Stroke, Acute
Intervention:   Other: CT
Sponsor:   Chinese PLA General Hospital
Recruiting

Stroke Home Rehabilitation With WeReha

Conditions:   Stroke, Acute;   Stroke
Intervention:   Device: WeReha
Sponsors:   CoRehab s.r.l.;   Engineering Ingegneria Informatica SpA;   Fondazione Bruno Kessler
Enrolling by invitation

A Novel Transition Program to Reduce Disability After Stroke

Conditions:   Ischemic Stroke;   Hemorrhagic Stroke
Interventions:   Behavioral: COMPASS;   Behavioral: Stroke education
Sponsors:   Washington University School of Medicine;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

THALES - Acute STroke or Transient IscHaemic Attack Treated With TicAgreLor and ASA for PrEvention of Stroke and Death

Conditions:   Acute Ischaemic Stroke;   Transient Ischaemic Attack
Interventions:   Drug: Ticagrelor;   Drug: Placebo
Sponsor:   AstraZeneca
Recruiting

Effectiveness of Balance Exercise Program for Stroke Patients With Pusher Syndrome

Conditions:   Pusher Syndrome;   Subacute Stroke
Interventions:   Other: Visual Feedback and Core Stability exercises protocol;   Other: Control stroke
Sponsors:   Parc Sanitari Pere Virgili;   Universitat Internacional de Catalunya
Recruiting

Study on the Effectiveness and Safety of Early Rehabilitation After Ischemic Stroke

Conditions:   Brain Ischemia;   Stroke Rehabilitation
Intervention:   Other: rehabilitation
Sponsor:   China Stroke Databank Center
Not yet recruiting

Comparison of Two Different Preload Targets of Stroke Volume Variation During Kidney Transplantation

Conditions:   Kidney Transplant; Complications;   Renal Failure Chronic
Interventions:   Other: Crystalloid fluid administration with the target of stroke volume variation ≤ 12%;   Other: Crystalloid fluid administration with the target of stroke volume variation ≤ 6%
Sponsor:   Seoul National University Hospital
Recruiting

Early Versus Late Initiation of Direct Oral Anticoagulants in Post-ischaemic Stroke Patients With Atrial fibrillatioN (ELAN): an International, Multicentre, Randomised-controlled, Two-arm, Assessor-blinded Trial

Condition:   Ischaemic Stroke
Interventions:   Drug: Early treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®);   Drug: Late treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®)
Sponsor:   University Hospital Inselspital, Berne
Recruiting

Dynamic Lycra Orthosis as an Adjunct to Botulinum Toxin-A Injection for Post-stroke Spasticity

Conditions:   Stroke;   Spasticity as Sequela of Stroke;   Upper Limb Hypertonia
Interventions:   Other: Lycra sleeve;   Other: Rehabilitation;   Drug: Botulinum Toxin
Sponsor:   Marmara University
Completed

Quelling of Excitotoxicity in Acute Stroke With Ketamine

Condition:   Acute Ischemic Stroke
Interventions:   Drug: Ketamine;   Other: Normal Saline;   Drug: Midazolam injection
Sponsors:   Doylestown Health;   Lower Merion Neurology
Not yet recruiting

Treat Stroke to Target

Conditions:   Ischemic Stroke;   Transient Ischemic Attack;   Atherosclerotic Stenosis
Interventions:   Procedure: Target : 100 mg/dL (+/-10 mg/dL);   Procedure: 70 mg/dL
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Pfizer;   AstraZeneca;   Merck Sharp & Dohme Corp.
Completed

Scalp Acupuncture for Dyskinesia After Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Other: Scalp acupuncture;   Other: Conventional rehabilitation
Sponsors:   Shanghai University of Traditional Chinese Medicine;   Fudan University
Recruiting

Transcranial Direct Current Stimulation and Functional Electrical Stimulation for Upper-limb Rehabilitation After Stroke

Condition:   Stroke
Interventions:   Device: Functional Electrical Stimulation (FES);   Device: Combination of Transcranial direct brain stimulation (tDCS) and FES
Sponsor:   Federal University of Health Science of Porto Alegre
Completed

Mantra Meditation in Subjects That Have Chronically Impaired Attention After Stroke

Condition:   Stroke Sequelae
Intervention:   Behavioral: mantra meditation
Sponsor:   Cheryl Carrico
Completed

Improving Coordination and Transitions of Care in Stroke Patients

Conditions:   Stroke;   Transient Ischemic Attack
Intervention:   Other: Nursing care model
Sponsor:   University of Pennsylvania
Active, not recruiting

Customized Cortical Stimulation Therapy in the Rehabilitation of Stroke Patients

Condition:   Stroke
Interventions:   Device: Single-pulse Transcranial Magnetic Stimulation (TMS);   Device: Paired-pulse Transcranial Magnetic Stimulation (ppTMS);   Device: Low-frequency Repetitive Transcranial Magnetic Stimulation (rTMS);   Device: Sham Motor Cortex Stimulation
Sponsors:   Emory University;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Effects of Touch Massage in the Sub-acute Phase After Stroke

Condition:   Stroke
Interventions:   Procedure: Touch massage;   Other: non-TENS
Sponsor:   Umeå University
Terminated

Chiropractic Care Plus Physiotherapy Compared to Physiotherapy Alone in Chronic Stroke Patients: a Pilot Study

Condition:   Chronic Stroke
Interventions:   Other: Experimental Group;   Other: Control group
Sponsor:   Riphah International University
Completed

Study on Rosuvastatin+Ezetimibe and Rosuvastatin for LDL-C Goal in Patients With Recent Ischemic Stroke

Condition:   Stroke, Ischemic
Interventions:   Drug: Experimental: Rosuvastatin/Ezetimibe 10;   Drug: Active Comparator: Rosuvastatin 20mg
Sponsors:   Keun-Sik Hong;   Ewha Womans University Seoul hospital;   Severance Hospital;   Korea University;   Korea University Guro Hospital;   Myongji Hospital;   Seoul St. Mary's Hospital;   Samsung Medical Center;   Seoul National University Hospital;   Chung-Ang University Hosptial, Chung-Ang University College of Medicine;   Hallym University Medical Center;   Kyunghee University Medical Center;   Inje University
Not yet recruiting

Physical Fitness Training in Subacute Stroke (PHYS-Stroke)

Condition:   Stroke
Interventions:   Procedure: physical fitness training;   Procedure: relaxation
Sponsor:   Charite University, Berlin, Germany
Completed

Enhancement of Stroke Rehabilitation With Levodopa

Conditions:   Acute Ischemic Stroke;   Stroke Rehabilitation
Interventions:   Drug: IMP Levodopa 100mg/Carbidopa 25mg;   Drug: Matching placebo
Sponsors:   University Hospital, Basel, Switzerland;   Swiss National Science Foundation
Recruiting

REMOTE Ischemic Perconditioning Among Acute Ischemic Stroke Patients ( REMOTE-CAT)

Condition:   Ischemic Stroke
Interventions:   Other: Remote ischemic perconditioning;   Other: Sham remote perconditioning
Sponsors:   Institut de Recerca Biomèdica de Lleida;   Instituto de Salud Carlos III
Enrolling by invitation

Sensory Augmentation Methods in Stroke

Condition:   Stroke
Interventions:   Behavioral: Sensory Augmentation;   Behavioral: Random Vibration
Sponsor:   VA Office of Research and Development
Not yet recruiting

This Study Uses the SITS Registry to Find Out When Patients With a Heart Rhythm Disorder (Atrial Fibrillation) Start Treatment With Dabigatran After They Had a Stroke

Condition:   Atrial Fibrillation
Intervention:   Drug: Dabigatran
Sponsors:   Boehringer Ingelheim;   SITS international registry, Karolinska University Hospital, Stockholm, Sweden
Active, not recruiting

Evaluating the Therapeutic Effect of Scalp Acupuncture Treatment for Motor Dysfunction in Ischemic Stroke Patients

Conditions:   Ischemic Stroke;   Hemiplegia
Interventions:   Device: Scalp Acupuncture Treatment;   Other: Rehabilitation treatment
Sponsors:   Shanghai University of Traditional Chinese Medicine;   Fudan University
Recruiting

Transcranial Direct Current Stimulation for Post-stroke Motor Recovery

Conditions:   Stroke, Ischemic;   Motor Activity;   Upper Extremity Paralysis
Interventions:   Device: Sham;   Device: Low dose tDCS;   Device: High dose tDCS;   Behavioral: mCIMT
Sponsors:   Medical University of South Carolina;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Biomarkers and Perfusion - Training-Induced Changes After Stroke

Condition:   Stroke
Intervention:  
Sponsor:   Charite University, Berlin, Germany
Completed

Patient Targeted Upper Extremity Rehabilitation After Stroke

Condition:   Stroke
Intervention:   Behavioral: Task Practice Physical Rehabilitation Therapy
Sponsors:   VA Office of Research and Development;   Medical University of South Carolina
Completed

GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

Conditions:   Stroke;   PFO - Patent Foramen Ovale
Intervention:   Device: PFO closure with GORE® CARDIOFORM Septal Occluder
Sponsor:   W.L.Gore & Associates
Recruiting

Study of Allogeneic Umbilical Cord Blood Infusion for Adults With Ischemic Stroke

Conditions:   Stroke;   Stroke, Acute;   Brain Injury, Acute
Interventions:   Biological: Umbilical Cord Blood;   Other: Placebo
Sponsors:   Joanne Kurtzberg, MD;   The Marcus Foundation;   Emory University;   M.D. Anderson Cancer Center
Recruiting

Feasibility of a Stroke Specific Self-management Program

Conditions:   Stroke;   Chronic Conditions
Interventions:   Other: Self- management program;   Other: Standard care
Sponsors:   The University of Texas Medical Branch, Galveston;   National Center for Advancing Translational Science (NCATS)
Not yet recruiting

A Novel Approach for Brain Stimulation in Severe Stroke

Condition:   Stroke
Interventions:   Device: New rTMS Approach;   Device: Conventional rTMS Approach
Sponsors:   The Cleveland Clinic;   American Heart Association
Recruiting

Genetic and Environmental Risk Factors for Hemorrhagic Stroke

Condition:   Stroke
Intervention:  
Sponsors:   University of Cincinnati;   National Institute of Neurological Disorders and Stroke (NINDS);   University of Maryland;   Massachusetts General Hospital;   Duke University, Durham, NC;   Columbia University, New York, New York;   University of Illinois Chicago, Chicago, Illinois
Recruiting

COMPLETE: International Acute Ischemic Stroke Registry With the Penumbra System Aspiration Including the 3D Revascularization Device

Condition:   Stroke, Ischemic
Intervention:   Device: Penumbra System
Sponsor:   Penumbra Inc.
Recruiting

Systematic Evaluation of Patients Treated With Stroke Devices for Acute Ischemic Stroke (STRATIS) Registry

Condition:   Ischemic Stroke
Intervention:  
Sponsor:   Medtronic Neurovascular Clinical Affairs
Completed

Self Directed Stations for the Stroke Patient

Condition:   Stroke
Intervention:   Other: Patient Directed Exercise Group
Sponsor:   Baylor Research Institute
Completed

Ticagrelol Versus Aspirin in Ischemic Stroke

Conditions:   Acute Stroke;   Ischemic Stroke
Interventions:   Drug: Ticagrelor (Brilique) 90;   Drug: Aspirin 75mg
Sponsors:   Kafrelsheikh University;   Ain Shams University
Recruiting

Effects of Exoskeleton-Assisted Gait Training on Functional Rehabilitation Outcomes in Patients With Stroke

Conditions:   Stroke;   Weakness of Extremities as Sequela of Stroke
Interventions:   Device: Indego Exoskeleton;   Other: Standard Rehabilitation
Sponsors:   University of Oklahoma;   Oklahoma City VA Health Care System
Not yet recruiting

Hispanic Secondary Stroke Prevention Initiative

Condition:   Stroke
Interventions:   Behavioral: Community Health Worker (CHW);   Other: usual care and health education brochures every 4 months.
Sponsors:   University of Miami;   National Institute on Minority Health and Health Disparities (NIMHD)
Completed

Practice-Based Trial of Home BP Telemonitoring Among Minority Stroke Survivors

Conditions:   Stroke;   Hypertension
Interventions:   Behavioral: Home BP Telemonitoring (HBPTM);   Behavioral: Nurse Case Management (NCM)
Sponsors:   NYU Langone Health;   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting

Utilizing Gaming Mechanics to Optimize Telerehabilitation Adherence in Persons With Stroke

Condition:   Stroke
Intervention:   Behavioral: Home Telerehabilitation using HoVRS
Sponsors:   Rutgers, The State University of New Jersey;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   New Jersey Institute of Technology
Not yet recruiting

Vessel Wall MR Imaging to Explore Sex-Differences of Intracranial Arterial Wall Changes After Suspected Stroke

Conditions:   Intracranial Atherosclerosis;   Acute Stroke;   Transient Ischemic Attack
Intervention:  
Sponsor:   University of Pennsylvania
Recruiting

Eptifibatide in Endovascular Treatment of Acute Ischemic Stroke (EPOCH)

Condition:   Acute Ischemic Stroke
Intervention:   Drug: Eptifibatide Injection
Sponsor:   Ministry of Science and Technology of the People´s Republic of China
Recruiting

The Therapeutic Effects of Peroneal Nerve Functional Electrical Stimulation for Lower Extremity in Patients With Sub-acute Post-stroke Hemiplegia

Condition:   Stroke
Interventions:   Device: WA group;   Other: Control
Sponsors:   Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan;   Nippon Medical School;   Kagoshima University
Active, not recruiting

Oral Factor XIa Inhibitor for the Prevention of New Ischemic Stroke in Patients Receiving Aspirin and Clopidogrel Following Acute Ischemic Stroke or Transient Ischemic Attack (TIA)

Conditions:   Acute Ischemic Stroke;   Transient Ischemic Attack (TIA)
Interventions:   Drug: BMS-986177;   Other: BMS-986177 Placebo;   Drug: Clopidogrel;   Drug: Aspirin
Sponsors:   Bristol-Myers Squibb;   Janssen, LP
Recruiting

The Role of Hyperoxia in Acute Ischemic Stroke

Condition:   Stroke, Acute
Interventions:   Other: Oxygen;   Other: placebo
Sponsors:   University of Rochester;   American Heart Association
Recruiting

Effects of Oropharyngeal Strengthening on Dysphagia in Patients Post-stroke

Condition:   Stroke
Interventions:   Device: Isometric Progressive Resistance Oropharyngeal Therapy;   Behavioral: Compensatory approaches
Sponsor:   University of Wisconsin, Madison
Completed

Bridging Thrombolysis Versus Direct Mechanical Thrombectomy in Acute Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Device: Stent-retriever thrombectomy with revascularization device of the Solitaire™ type;   Drug: Intravenous thrombolysis with recombinant tissue-type plasminogen activator (IV t-PA)
Sponsors:   University Hospital Inselspital, Berne;   Medtronic
Recruiting

Association Between Brain Stimulations for the Rehabilitation of Chronic Stroke Patients

Condition:   Stroke
Interventions:   Device: tDCS;   Device: TMS;   Device: tDCS + TMS
Sponsor:   Federal University of Health Science of Porto Alegre
Completed

The Effects of Whole Body Vibration in People With Chronic Stroke

Condition:   Stroke
Interventions:   Procedure: High frequency whole body vibration;   Procedure: Low frequency whole body vibration
Sponsor:   The Hong Kong Polytechnic University
Completed

Nutrition and Aerobic Exercise in Chronic Stroke

Condition:   Stroke
Interventions:   Behavioral: Treadmill Exercise;   Behavioral: Stretching (control)
Sponsor:   VA Office of Research and Development
Active, not recruiting

Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies

Conditions:   Aphasia;   Nonfluent Aphasia;   Stroke
Intervention:  
Sponsors:   VA Office of Research and Development;   Boston University
Active, not recruiting

MEditation for Post Stroke Depression

Conditions:   Stroke;   Depression
Interventions:   Behavioral: Breath-based meditation;   Behavioral: Meditation educational materials
Sponsor:   The University of Texas Health Science Center, Houston
Completed

Recovery of Impairments Early After Stroke

Condition:   Stroke
Intervention:   Behavioral: Assessment of behavioral biometric impairments
Sponsor:   University of Zurich
Recruiting

A Very Early Standing Study in Elderly Stroke

Condition:   Stroke
Intervention:   Procedure: Verticalization
Sponsor:   Centre Hospitalier Régional d'Orléans
Recruiting

Exercise and Motor Learning After Stroke

Condition:   Stroke
Intervention:   Behavioral: Exercise
Sponsor:   University of Delaware
Active, not recruiting

Fostering Eating After Stroke With Transcranial Direct Current Stimulation

Conditions:   Dysphagia;   Stroke
Intervention:   Device: tDCS
Sponsors:   Beth Israel Deaconess Medical Center;   National Institute on Deafness and Other Communication Disorders (NIDCD)
Active, not recruiting

Comparison of Robot-assisted Gait Training According to Gait Speed in Participants With Stroke

Condition:   Stroke
Interventions:   Other: Constant gait speed group;   Other: Increasing gait speed group
Sponsor:   National Rehabilitation Center, Seoul, Korea
Not yet recruiting

Rescue Stenting for Failed Endovascular Thrombectomy in Acute Ischemic Stroke (ReSET)

Conditions:   Acute Ischemic Stroke;   Intracranial Artery Occlusion
Intervention:   Device: Rescue stenting
Sponsor:   Yonsei University
Not yet recruiting

Vitality: Promoting Cognitive Function in Older Adults With Chronic Stroke

Conditions:   Stroke;   Chronic Stroke
Interventions:   Behavioral: Exercise training;   Behavioral: Complex mental and social activities;   Behavioral: Control: stretching and relaxation program
Sponsors:   University of British Columbia;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting

Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of DS-1040b in Subjects With Acute Ischemic Stroke

Conditions:   Acute Ischemic Stroke;   Thrombotic Disease
Interventions:   Drug: DS-1040b;   Drug: Placebo
Sponsor:   Daiichi Sankyo, Inc.
Active, not recruiting

Study of Botulinum Toxin and Recovery of Hand Function After Stroke

Condition:   Stroke With Hemiparesis
Interventions:   Drug: Botulinum Toxin commonly known as BOTOX®;   Drug: Placebo
Sponsors:   NYU Langone Health;   Allergan
Completed

Evaluation of the Effectiveness and Safety of Keeogo™ Dermoskeleton in Subjects With Mobility Impairments Due to Stroke

Conditions:   Stroke, Ischemic;   Stroke Hemorrhagic;   Stroke;   Hemiparesis;   Cerebral Vascular Accident
Intervention:   Device: Keeogo™ Dermoskeleton
Sponsor:   B-Temia, Inc.
Not yet recruiting

Personalized Antiplatelet Secondary Stroke PRevenTion

Conditions:   Ischemic Stroke;   TIA
Interventions:   Drug: tailored antiplatelet selection;   Drug: standard of care
Sponsor:   State University of New York - Upstate Medical University
Recruiting

Thrombectomy In TANdem Occlusion

Conditions:   Carotid Artery Diseases;   Thrombectomy;   Tandem Occlusion;   Stroke
Interventions:   Device: Carotid Stenting;   Drug: Procedural Aspirin;   Drug: Dual dual antiplatelet therapy after 24-hours imaging follow-up;   Procedure: Intracranial thrombectomy
Sponsor:   Central Hospital, Nancy, France
Not yet recruiting

Investigation of Neural Stem Cells in Ischemic Stroke

Conditions:   Ischemic Stroke;   Chronic Stroke;   Hemiparesis;   Arm Paralysis
Interventions:   Combination Product: CTX0E03 Drug Product and delivery device;   Drug: Placebo
Sponsor:   ReNeuron Limited
Recruiting

Moving a Paralyzed Hand Through Use of a Brain-Computer Interface

Condition:   Stroke
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Center for Neuroscience and Regenerative Medicine (CNRM)
Terminated

Intracranial Thrombosis Aspiration Catheter for Recanalization in Acute Ischemic Stroke Therapy (RECOVER)

Conditions:   Large Vessel Occlusion;   Acute Ischemic Stroke;   Cerebrovascular Disorders
Interventions:   Device: Aspiration Catheter;   Device: Solitaire FR
Sponsor:   Ministry of Science and Technology of the People´s Republic of China
Recruiting

Study of the Metrological Properties of Two Assessment Grids of the Driving Capacity After a Cerebrovascular Accident (ROADTRIP)

Condition:   Stroke
Intervention:   Diagnostic Test: On-road driving evaluation
Sponsor:   University Hospital, Clermont-Ferrand
Recruiting

The Comparison of Virtual and Real Boxing Training in Hemiparetic Stroke Patients

Conditions:   Stroke;   Hemiparesis
Interventions:   Other: real boxing training;   Other: virtual boxing training
Sponsor:   Eastern Mediterranean University
Completed

Safety and Efficacy of Glibenclamide Combined With Rt-PA in Acute Cerebral Embolism

Condition:   Acute Stroke
Interventions:   Drug: Glibenclamide;   Drug: Placebo
Sponsor:   Nanfang Hospital of Southern Medical University
Recruiting

Prevalence of Strokes Secondary to a Reversible Cerebral Vasoconstriction Attributable to Cannabis Consumption in Young Subjects (≤ 45 Years) Hospitalized for an Ischaemic Stroke

Conditions:   Stroke;   Cannabis Use
Intervention:   Other: Drug urinal test
Sponsor:   University Hospital, Strasbourg, France
Recruiting

Stroke Gait Rehabilitation Using Functional Electrical Stimulation

Condition:   Cerebrovascular Accident
Interventions:   Device: Functional electrical stimulation (FES);   Other: Fast Treadmill Walking
Sponsors:   Emory University;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   American Heart Association
Recruiting

Development of a FES Device for Hand Use During Arm Activities Following Stroke

Conditions:   Stroke;   Hand Function
Intervention:   Device: ReIn-Hand device assisted home-based practice
Sponsor:   Northwestern University
Not yet recruiting

Development of a National Protocol for Stroke Rehabilitation in a Multicenter Italian Institution

Conditions:   Stroke;   Rehabilitation
Intervention:   Other: Rehabilitative intervention
Sponsor:   Fondazione Don Carlo Gnocchi Onlus
Completed

Effects of Virtual Reality on Dual Task Performance

Condition:   Stroke
Interventions:   Other: virtual reality;   Other: robotic gait
Sponsor:   Hacettepe University
Completed

Premotor Cortex: A New Target for Stroke Motor Rehabilitation

Condition:   Stroke
Interventions:   Device: rTMS over Premotor Cortex (Contralateral Hemisphere);   Device: rTMS over Premotor Cortex (Ipsilateral Hemisphere);   Device: rTMS (Control 1);   Device: rTMS (Control 2);   Device: rTMS (Control 3);   Other: Motor Training
Sponsors:   Emory University;   American Heart Association
Recruiting

Optimizing Current and Electrode Montage for Transcranial Direct Current Stimulation in Stroke Patients

Condition:   Stroke
Intervention:   Device: transcranial direct current stimulation
Sponsor:   Medical University of South Carolina
Completed

Enhanced Reality for Hemiparetic Arm in the Stroke Patients

Conditions:   Stroke;   Paresis;   Mirror Movement
Interventions:   Device: Enhanced reality;   Other: No Enhanced reality
Sponsor:   Ulsan University Hospital
Recruiting

Impact of Verticalization on Intracranial Hemodynamics Assessed in Transcranial Doppler at the Acute Phase of Cerebral Infarction

Condition:   Stroke
Intervention:   Other: Transcranial Doppler
Sponsor:   Fondation Ophtalmologique Adolphe de Rothschild
Not yet recruiting

Collateral-based reSetting of Endovascular Treatment Time Window for Stroke (CoSETS)

Condition:   Acute Ischemic Stroke
Intervention:   Procedure: endovascular thrombectomy
Sponsor:   Yonsei University
Completed

Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury

Condition:   Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury
Interventions:   Drug: NT 201;   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Not yet recruiting

Effect of Personalized Robotic Therapy

Condition:   Stroke
Interventions:   Device: Arm Light Exoskeleton Rehab Station (ALEx RS);   Device: Arm Light Exoskeleton Rehab Station (ALEx RS) - automatically personalized
Sponsors:   Wearable Robotics srl.;   University Hospital, Geneva;   Azienda Ospedaliero, Universitaria Pisana;   Ecole Polytechnique Fédérale de Lausanne
Recruiting

Assessment of the WATCHMAN™ Device in Patients Unsuitable for Oral Anticoagulation

Condition:   Stroke
Interventions:   Device: WATCHMAN LAAC Device Implant;   Drug: Single Antiplatelet Therapy or No Therapy (Control)
Sponsor:   Boston Scientific Corporation
Recruiting

Fluoxetine Opens Window to Improve Motor Recovery After Stroke

Conditions:   Stroke;   Cerebrovascular Accident;   Cerebral Infarction;   Brain Infarction;   Brain Ischemia;   Cerebrovascular Disorders;   Brain Diseases;   Central Nervous System Diseases;   Nervous System Diseases;   Vascular Diseases
Interventions:   Drug: Fluoxetine Hydrochloride;   Other: Placebo;   Behavioral: Exercise Program
Sponsors:   University Health Network, Toronto;   University of British Columbia;   Sunnybrook Health Sciences Centre;   University of Calgary;   Dalhousie University;   Parkwood Hospital, London, Ontario;   Riverview Health Centre, Winnipeg, Manitoba;   Memorial University of Newfoundland;   Applied Health Research Centre;   Brain Canada;   Heart and Stroke Foundation Canadian Partnership for Stroke Recovery
Recruiting

Take Off Pounds After Stroke Trial (TOPS)

Conditions:   Stroke;   Obesity;   Overweight;   Hemiparesis
Interventions:   Behavioral: Partial meal replacement program;   Behavioral: Dietary Counseling
Sponsors:   Beth Israel Deaconess Medical Center;   Yale University
Not yet recruiting

Cost-effectiveness of Forced Aerobic Exercise for Stroke Rehabilitation

Conditions:   Stroke;   Cerebrovascular Disorders;   Brain Diseases;   Central Nervous System Diseases;   Nervous System Diseases;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Behavioral: Aerobic Exercise;   Behavioral: Upper Extremity Repetitive Task Practice
Sponsor:   The Cleveland Clinic
Recruiting

INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority

Condition:   Rheumatic Heart Disease
Interventions:   Drug: Rivaroxaban (15 mg);   Drug: Aspirin
Sponsors:   Population Health Research Institute;   University of Cape Town
Not yet recruiting

Balance Rehabilitation With Sensory Recalibration After Stroke

Condition:   Left-sided Hemiplegia Affecting Dominant Side as Late Effect of Cerebrovascular Accident
Interventions:   Other: Cervical vibration;   Other: Prism adaptation;   Other: Conventional rehabilitation
Sponsor:   Rennes University Hospital
Recruiting

Rehabilitating Corticospinal Control of Walking

Condition:   Stroke
Interventions:   Behavioral: ACC training;   Behavioral: SS training
Sponsors:   VA Office of Research and Development;   University of Florida;   Brooks Rehabilitation
Completed

rTMS Plus CCFES-mediated Functional Task Practice for Severe Stroke

Conditions:   Stroke;   Hemiplegia;   Cerebrovascular Accident (CVA);   Hemiparesis
Interventions:   Device: Contralaterally Controlled Functional Electrical Stimulation;   Device: New rTMS approach;   Device: Conventional rTMS approach;   Device: Sham rTMS approach
Sponsors:   The Cleveland Clinic;   National Institutes of Health (NIH)
Recruiting

The Pilot Study of TACs Therapy for PSD

Condition:   Post-stroke Depression
Interventions:   Device: NEXALIN ADI AC stimulator;   Device: Pseudo-stimulator
Sponsor:   Xuanwu Hospital, Beijing
Recruiting

Application of Platelet Function Test in Prevention of Ischemic Stroke After Stent Placement in Intracranial Aneurysms

Conditions:   Unruptured Intracranial Aneurysm;   Stents;   Antiplatelet Drugs
Interventions:   Drug: Aspirin and clopidogrel/Ticagrelor;   Device: Light transmittance aggregometry
Sponsor:   Beijing Neurosurgical Institute
Recruiting

fMRI Neurofeedback for Motor Rehabilitation

Conditions:   Stroke;   fMRI
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Xarelto on Prevention of Stroke and Non-Central Nervous Systemic Embolism in Renally Impaired Korean Patients With Non-valvular Atrial Fibrillation

Condition:   Non-valvular Atrial Fibrillation (NVAF)
Intervention:   Drug: Rivaroxaban(Xarelto,BAY 59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting

White Matter Connections and Memory: the STRATEGIC Study

Conditions:   Stroke;   Cognitive Impairment;   Memory Impairment
Intervention:  
Sponsor:   King's College London
Active, not recruiting

Contralaterally Controlled FES of Arm & Hand for Subacute Stroke Rehabilitation

Conditions:   Stroke;   Hemiparesis;   Hemiplegia
Intervention:   Device: Electrical stimulator
Sponsors:   MetroHealth Medical Center;   Case Western Reserve University;   National Institutes of Health (NIH);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed

Effects of Prism Adaption and rTMS on Brain Connectivity and Visual Representation

Conditions:   Normal Physiology;   Stroke
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Study to Learn More About the Benefits and Side-effects of Drugs Rivaroxaban and Apixaban Compared to the Drug Warfarin for Stroke Prevention in Patients With Rapid and Irregular Heartbeat Which is Not Due to a Heart-valve Fault (Non-valvular Atrial Fibrillation) in the UK Routine Clinical Practice

Condition:   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Apixaban (Eliquis);   Drug: Warfarin
Sponsors:   Bayer;   Janssen, LP
Active, not recruiting

Cerebellar Transcranial Direct Current Stimulation and Aphasia Treatment

Condition:   Stroke
Interventions:   Device: Anodal or Cathodal tDCS;   Device: Sham;   Behavioral: Computerized naming therapy
Sponsors:   Johns Hopkins University;   National Institute on Deafness and Other Communication Disorders (NIDCD)
Recruiting

Rivaroxaban vs Warfarin for SPAF in Multi-morbid Patients

Condition:   Nonvalvular Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Vitamin K antagonist(VKA)
Sponsor:   Bayer
Active, not recruiting

Post-Embolic Rhythm Detection With Implantable Versus External Monitoring

Conditions:   Stroke;   Atrial Fibrillation;   Arrhythmias, Cardiac
Interventions:   Device: Medtronic Reveal LINQ;   Device: Sorin Spiderflash-t
Sponsors:   University of Alberta;   University of Calgary;   Alberta Innovates Health Solutions;   Medtronic
Active, not recruiting

Treatment Outcomes With tDCS in Post-Stroke Aphasia

Condition:   Aphasia
Interventions:   Device: Active Transcranial Direct Current Stimulation with SLT;   Device: Sham Transcranial Direct Current Stimulation with SLT
Sponsor:   University of Arkansas
Not yet recruiting

An Observational Study of Natural History of Cardiovascular Diseases

Conditions:   Stroke;   Heart Attack;   TIA;   Cardiovascular Diseases
Intervention:  
Sponsors:   Imperial College London;   University of Oxford;   Clinical Trial Service Unit and Epidemiological Studies Unit
Completed

Post Market Surveillance Study of the Wingspan Stent System

Condition:   Intracranial Atherosclerosis
Intervention:   Device: Wingspan Stent System
Sponsor:   Stryker Neurovascular
Active, not recruiting

Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity

Conditions:   Overweight;   Obesity
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

Comparison of Transthoracic Electrical Bioimpedance and Pulse Contour Analysis in Renal Transplantation Patients

Condition:   Hemodynamic Monitoring
Interventions:   Device: Transthoracic Electrical Bioimpedance;   Device: Pulse Contour Analysis
Sponsor:   Dita Aditianingsih
Completed

Translation and Validation Fugl-Meyer in Italian Language

Condition:   Validation Fugl Meyer Scale in Italian
Intervention:  
Sponsors:   Fondazione Don Carlo Gnocchi Onlus;   Göteborg University
Active, not recruiting

Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Biological: Apolipoprotein A-I [human] (apoA-I);   Other: Placebo
Sponsor:   CSL Behring
Recruiting

A Nationwide Observational Study Looking at Effectiveness and Bleeding Complications of NOACs vs. VKA in Non-valvular Atrial Fibrillation Patients.

Condition:   Non-valvular Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Apixaban (Eliquis);   Drug: Dabigatran etexilate (Pradaxa);   Drug: Warfarin (Marevan)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

The Movement of Botulinum Toxin Through the Lateral Gastrocnemius Muscle in Humans: An Expanded Examination

Conditions:   Stroke;   Muscle Spasticity
Intervention:   Drug: Botox
Sponsors:   Weill Medical College of Cornell University;   Allergan
Recruiting

Exergames Balance Program in Neurorehabilitation

Conditions:   Stroke;   Multiple Sclerosis;   Balance Disorders
Intervention:   Device: MindMotion GO
Sponsors:   Klinik Valens;   Mindmaze SA;   KU Leuven
Recruiting

GLORIA-AF Registry Program - Second and Third Phases

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Quantitative Flow Ratio Guided Revascularization Strategy for Patients Undergoing Primary Valve Surgery With Comorbid Coronary Artery Disease

Conditions:   Primary Valvular Heart Disease With Comorbid Coronary Artery Disease;   Planned to Undergo Elective On-pump Valve Surgery Due to Primary Mitral and/or Aortic Valvular Heart Disease
Interventions:   Device: QFR-guided strategy;   Other: CAG-guided strategy
Sponsors:   Ruijin Hospital;   Med-X Research Institute, Shanghai Jiao Tong University
Not yet recruiting

Spaced Versus Massed Skill Learning

Condition:   Healthy Volunteer
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

AcoArt VI / Vertebral Artery Ostium Stenosis in China

Condition:   Ischemic Stroke
Interventions:   Procedure: drug-coated balloon catheter(Orchid, Acotec);   Procedure: Intracranial artery stent system(APOLLO)
Sponsor:   Acotec Scientific Co., Ltd
Not yet recruiting

Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: liraglutide;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Completed

DACAB Trial: Follow-up Extension

Conditions:   Coronary Artery Bypass Grafting;   Antiplatelet Therapy
Intervention:   Other: non-interventional
Sponsor:   Ruijin Hospital
Not yet recruiting

Efficacy and Safety of DaxibotulinumtoxinA for Injection for the Treatment of Adult Upper Limb Spasticity

Condition:   Upper Limb Spasticity
Interventions:   Biological: DAXI for injection dose LOW DOSE;   Biological: DAXI for injection dose MEDIUM DOSE;   Biological: DAXI for injection Dose HIGH DOSE;   Other: Placebo
Sponsor:   Revance Therapeutics, Inc.
Recruiting

Evaluation of Ambulatory ECG Telemetry for the Early Detection of Atrial Fibrillation During Hospital Assessment of Cerebral Infarction

Condition:   Cerebral Infarction
Intervention:   Device: ECG telemetry
Sponsor:   Hopital Foch
Recruiting

Medtronic Evolut Transcatheter Aortic Valve Replacement in Low Risk Patients

Condition:   Aortic Valve Stenosis
Interventions:   Device: Medtronic Transcatheter Aortic Valve Replacement Systems;   Device: Surgical Aortic Valve Replacement (SAVR)
Sponsor:   Medtronic Cardiovascular
Recruiting

Edoxaban Compared to Standard Care After Heart Valve Replacement Using a Catheter in Patients With Atrial Fibrillation (ENVISAGE-TAVI AF)

Condition:   Atrial Fibrillation
Interventions:   Drug: Edoxaban-based Regimen;   Drug: VKA-based Regimen
Sponsors:   Daiichi Sankyo, Inc.;   Chiltern International Inc.
Recruiting

Large-Scale Online Studies of Motor Responses and Cognition

Condition:   Healthy Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting

SGLT2 Inhibitor or Metformin as Standard Treatment of Early Stage Type 2 Diabetes

Condition:   Type 2 Diabetes
Interventions:   Drug: Metformin;   Drug: Dapagliflozin 10 MG
Sponsors:   Uppsala University;   Uppsala University Hospital;   Swedish Healthcare Regions;   Swedish National Board of Health and Welfare;   The Swedish National Diabetes Register
Recruiting

Assessing Clinical Endpoints and Biomarkers in Myotonic Dystrophy Type-1 and Type 2 (ASCEND-DM)

Conditions:   Myotonic Dystrophy Type-1;   Myotonic Dystrophy Type-2
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Completed

Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders

Conditions:   Alzheimer's Disease;   Dementia;   Down's Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Infants With Spinal Muscular Atrophy Type I

Condition:   Spinal Muscular Atrophy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Genetics of Motor Learning

Conditions:   Parkinson s Disease;   Dystonic Disorders;   Focal Dystonia;   Movement Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

BLOC-ICH: Interleukin-1 Receptor Antagonist in Intracerebral Haemorrhage

Condition:   Intracerebral Haemorrhage
Interventions:   Drug: IL-1Ra Kineret®;   Other: IL-1Ra Placebo
Sponsors:   Adrian Parry-Jones;   Salford Royal NHS Foundation Trust;   National Institute for Health Research, United Kingdom;   Manchester University NHS Foundation Trust
Recruiting

Proprioception Testing in Persons With Sensorimotor Impairment

Conditions:   Spinal Cord Injury;   Stroke;   Acquired Brain Injury
Intervention:   Device: AMES Therapy
Sponsor:   Oregon Health and Science University
Terminated

Supporting Patients Undergoing HIgh-Risk PCI Using a High-Flow PErcutaneous Left Ventricular Support Device (SHIELD II)

Condition:   Coronary Artery Disease
Interventions:   Device: HeartMate PHP;   Device: Any Abiomed Impella® device approved for use in high-risk PCI
Sponsor:   Abbott Medical Devices
Recruiting

Study of DU-176b Aged 80 Years or Older

Condition:   Atrial Fibrillation
Interventions:   Drug: Du-176b;   Drug: placebo
Sponsor:   Daiichi Sankyo Co., Ltd.
Recruiting

A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Events

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: insulin degludec;   Drug: insulin glargine
Sponsor:   Novo Nordisk A/S
Completed

A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Completed

Comparison of Anticoagulation Prolongation vs. no Anticoagulation in STEMI Patients After Primary PCI

Condition:   STEMI - ST Elevation Myocardial Infarction
Interventions:   Drug: Bivalirudin;   Drug: Enoxaparin;   Drug: Unfractionated heparin;   Drug: Bivalirudin placebo;   Drug: Enoxaparin placebo syringe;   Drug: Unfractionated heparin placebo
Sponsors:   Beijing Anzhen Hospital;   Chinese Academy of Medical Sciences, Fuwai Hospital;   ACTION Study Group (Pitié-Salpêtrière Hospital), Paris, France
Recruiting

The VA Diabetes Trial Follow-up Study (VADT-FS)

Conditions:   Diabetes;   Glycemic Control
Intervention:  
Sponsor:   VA Office of Research and Development
Completed

Long-Term Improvement in Motor Learning by Transcranial Direct Current Stimulation

Condition:   Healthy Volunteers
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   United States Department of Defense;   Center for Neuroscience and Regenerative Medicine (CNRM);   National Institutes of Health Clinical Center (CC)
Completed

Safety of Terminating the Use of Aspirin After Left Atrial Appendage Closure

Condition:   Atrial Fibrillation
Intervention:   Drug: Termination of aspirin
Sponsor:   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Recruiting

Goal-directed Fluid Therapy in Elderly Patients Undergoing Lumbar Surgery

Conditions:   Postoperative Complications;   Fluid Overload
Intervention:   Other: Applying goal-directed fluid therapy by continuous hemodynamic monitoring system (LiDCO)
Sponsor:   Peking Union Medical College Hospital
Completed

RIvoraxaban in Mitral Stenosis

Conditions:   Mitral Stenosis;   Rheumatic Heart Disease;   Atrial Fibrillation;   Anticoagulant Adverse Reaction
Interventions:   Drug: Rivaroxaban;   Drug: Warfarin
Sponsors:   Rajaie Cardiovascular Medical and Research Center;   National Institute for Medical research and Development (NIMAD);   Abidi Pharmaceuticals
Recruiting

Rehabilitation of Attention in Patients With MCI and Brain Subcortical Vascular Changes Using the APT-II

Condition:   Mild Cognitive Impairment
Intervention:   Behavioral: Attention Process Training-II
Sponsors:   Azienda Ospedaliero-Universitaria Careggi;   Ministero della Salute, Italy
Completed

Feasibility of Endosphenoidal Coil Placement for Imaging of the Sella During Transsphenoidal Surgery

Condition:   Pituitary Neoplasm
Intervention:   Device: ENDOSPHENOIDAL COIL
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Clinical Laboratory Evaluation of Chronic Autonomic Failure

Conditions:   Parkinson's Disease;   Multiple System Atrophy;   Autonomic Failure
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Cytokine Microdialysis for Real-Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade

Condition:   Glioblastoma
Interventions:   Drug: Nivolumab;   Drug: BMS-986016
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Investigating Epilepsy: Screening, Evaluation and Treatment

Conditions:   Seizures;   Epilepsy;   Epilepsy, Temporal Lobe;   Partial Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Non-invasive Intermittent Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex in People With Functional Movement Disorders

Condition:   Movement Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Technical Development of Clinical Laboratory Studies

Condition:   Healthy Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting

PD-1 Inhibition to Determine CNS Reservoir of HIV-Infection

Condition:   HIV Infections
Intervention:   Drug: Pembrolizumab
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Measuring the Latency Connectome in the Central Nervous Systems Using Neuroimaging and Neurophysiological Techniques

Condition:   Healthy Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Pathophysiology of Dystonia and Complex Regional Pain Syndrome

Conditions:   Dystonia;   Complex Regional Pain Syndromes
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Loss of Depotentiation in Focal Dystonia

Conditions:   Focal Dystonia;   Healthy Volunteers
Intervention:   Other: PAS25-cTBS150
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Clinical and Physiological Studies of Tremor Syndromes

Conditions:   Parkinson Disease;   Dystonia;   Essential Tremor
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31

Condition:   Hereditary Spastic Paraplegia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD

Condition:   Coronary Artery Disease
Interventions:   Drug: High dose potent statin;   Drug: ACE-I (lisinopril) or ARB (losartan);   Drug: Aspirin;   Behavioral: Lifestyle Counseling;   Behavioral: Quality of Life Questionnaires
Sponsors:   University of Florida;   United States Department of Defense
Recruiting

Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk

Conditions:   Type 2 Diabetes Mellitus;   Chronic Kidney Diseases
Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: Placebo
Sponsor:   Sanofi
Recruiting

Myalgic Encephalomyelitis Chronic Fatigue at the National Institutes of Health

Condition:   Chronic Fatigue Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Tumor Related Epilepsy

Conditions:   Epilepsy;   Cancer;   Brain Neoplasm
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection

Conditions:   HIV Infections;   Neurologic Disorders
Intervention:   Drug: Anakinra
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Johns Hopkins University
Terminated

Oral Guanabenz for Multiple Sclerosis

Conditions:   Multiple Sclerosis, Relapsing-Remitting;   Multiple Sclerosis
Intervention:   Drug: Guanabenz
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Feasibility Study of Deep Brain Recordings for Learning and Memory

Condition:   Movement Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Withdrawn

Clinical Autonomic Disorders: A Training Protocol

Conditions:   Chronic Fatigue Syndrome;   Pseudopheochromocytoma;   Healthy Volunteers;   Neurocardiogenic Syncope;   Postural Tachycardia Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Deep Brain Stimulation Therapy in Movement Disorders

Conditions:   Parkinson's Disease;   Movement Disorders;   Deep Brain Stimulation;   Dystonia;   Essential Tremor
Intervention:   Other: Deep Brain Stimulation Management
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database

Condition:   Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Imaging Studies of Cognitive Impairment in Parkinson s Disease

Conditions:   Parkinson Disease;   Dementia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Deep Brain Stimulation for Refractory Alcoholism

Condition:   Alcoholism
Intervention:   Procedure: Implantation of Deep Brain Stimulation
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Withdrawn

AAV2-GDNF for Advanced Parkinson s Disease

Condition:   Parkinson's Disease
Intervention:   Genetic: Convection enhanced delivery/AAV2-GDNF
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting

Taurine Therapy for SSADH Deficiency

Condition:   Succinic Semialdehyde Dehydrogenase
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Botulinum Toxin for Pelvic Pain in Women With Endometriosis

Conditions:   Endometriosis;   Chronic Pelvic Pain;   Pelvic Muscle Spasms;   Quality of Life
Interventions:   Drug: Botuninum toxin A;   Drug: Placebo
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting

The Effects of Chronic Exposure to Low-Level Blasts

Condition:   Tramatic Brain Injury
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Walter Reed Army Institute of Research (WRAIR);   Naval Medical Research Center
Recruiting

Buspirone Therapy for Localized Epilepsy

Conditions:   Anxiety Disorder;   Seizures;   Epilepsy;   Partial Epilepsy;   Depression
Intervention:   Drug: Buspirone
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Combined Deep Brain Stimulation for Parkinson's Disease

Condition:   Parkinson Disease
Intervention:   Procedure: DBS Surgery
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Withdrawn

Octanoic Acid for Essential Tremor

Condition:   Essential Tremor
Intervention:   Drug: Octanoic Acid
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Structural and Functional Neuroimaging Studies of Combat Veterans

Conditions:   Traumatic Brain Injury;   PTSD
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Center for Neuroscience and Regenerative Medicine (CNRM)
Completed

Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients

Conditions:   Neoplasms;   Nervous System Disease;   Vestibular Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Ethanol Response in Essential Tremor: Clinical and Neurophysiological Correlates

Condition:   Essential Tremor
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

A Prospective Natural History Study of Patients With Syringomyelia

Conditions:   Syringomyelia;   Arnold Chiari Deformity
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting

Oxidative Stress in Motor Neuron Disease: COSMOS Add-On Study

Conditions:   Motor Neuron Disease;   Primary Lateral Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Evaluation, Pathogenesis, and Outcome of Subjects With or Suspected Traumatic Brain Injury

Condition:   Traumatic Brain Injury
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   Center for Neuroscience and Regenerative Medicine (CNRM);   United States Department of Defense;   Henry M. Jackson Foundation for the Advancement of Military Medicine
Recruiting

SMN Copy Number Distribution in Mali, West Africa

Condition:   Spinal Muscular Atrophy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Cerebral Activity Related to Primary Motor Stereotypies in Children: An EEG Study.

Condition:   Movement Disorder
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Recording and Modulation of Neuronal Mechanisms During Operant Conditioning: a MEG Study

Condition:   Central Nervous System
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Depression;   Depressive Disorder, Major
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Role of the Sensory Experience in Generating Motor Tics in Tourette Syndrome

Conditions:   Tic Disorder;   Tourette Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Language Mapping in Patients With Epilepsy

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Partial Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Relationship of HHV-6B Virus to Seizures and Brain Injury

Conditions:   Epilepsy;   HHV6B Infection
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

Condition:   Coronary Artery Disease
Interventions:   Other: Nitrous Oxide;   Other: No Nitrous Oxide
Sponsors:   Bayside Health;   National Health and Medical Research Council, Australia
Completed

Neurobiology of Psychogenic Movement Disorder and Non-Epileptic Seizures

Conditions:   Psycogenic Movement Disorders;   Non-epileptic Seizures
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Brain Changes in Blepharospasm

Conditions:   Dystonia;   Focal Dystonia;   Cerebellar Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Brain Peripheral Benzodiazepine Receptors in Patients With Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:   Radiation: [(11)C]PBR28
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Detecting a Reward Signal in the Motor Cortex

Condition:   Healthy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Biomarkers in Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Long-Term Motor Learning in Focal Hand Dystonia

Condition:   Focal Hand Dystonia
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Reference Values for Plasma Catechols

Conditions:   Healthy Volunteers;   Normal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Training for Diagnosing Neurological Disorders

Condition:   Musculoskeletal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo
Sponsor:   Novo Nordisk A/S
Recruiting

Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

Condition:   HTLV-1
Intervention:   Drug: Hu MiK-Beta-1
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Evaluation of Primary Chronic Autonomic Failure

Condition:   Autonomic Nervous System Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Phenotype/Genotype Correlations in Movement Disorders

Condition:   Movement Disorder
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Screening and Natural History: Primary Lateral Sclerosis and Related Disorders

Condition:   Primary Lateral Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Evaluation and Treatment of Patients With Epilepsy

Condition:   Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

A Study of Continuous Infusions of HNO (Nitroxyl) Donor in Patients With Heart Failure and Impaired Systolic Function

Conditions:   Heart Failure;   Cardiac Failure;   Reduced Ventricular Ejection Fraction
Interventions:   Drug: HNO Donor;   Drug: Nitroglycerin (NTG);   Other: Placebo
Sponsor:   Bristol-Myers Squibb
Completed

REPRISE IV: LOTUS Edge Valve System in Intermediate Surgical Risk Subjects

Condition:   Aortic Valve Stenosis
Intervention:   Device: LOTUS Edge Valve System
Sponsor:   Boston Scientific Corporation
Recruiting

Cardiopulmonary Changes Prolonged Surgical Abdominal Retractors Application in Supine Versus Lateral Position

Condition:   Cardio-pulmonary
Intervention:   Other: monitoring
Sponsor:   Mansoura University
Completed

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Conditions:   Acute Coronary Syndrome;   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Prevention of New Onset AF After TAVI (PAF-TAVI Trial)

Condition:   Atrial Fibrillation New Onset
Intervention:   Procedure: transcatheter aortic valve implantation
Sponsor:   Luis Nombela Franco
Not yet recruiting

Study Title: Food Rx

Conditions:   Diabetes;   High Blood Pressure;   Obesity;   Hypertension;   Heart Diseases;   Stroke;   TIA;   Osteoarthritis;   Cancer
Intervention:   Behavioral: Nutrition Education
Sponsor:   Mayo Clinic
Recruiting

Patent Foramen Ovale (PFO) Closure at the Time of Endovascular Cardiac Electronic Device Implantation

Condition:   Foramen Ovale, Patent
Interventions:   Drug: Aspirin;   Device: Cardiovascular Implantable Device (CIED);   Device: Gore Cardioform Septal Occluder
Sponsor:   Mayo Clinic
Not yet recruiting

Cerebral Autoregulation Monitoring During Cardiac Surgery

Conditions:   Thoracic Surgery;   Cardiopulmonary Bypass
Interventions:   Drug: blood pressure maintenance based on cerebral blood flow autoregulation measurement;   Drug: Control group
Sponsors:   Northwestern University;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Left Atrial Appendage Occlusion in Patients With Non-valvular Atrial Fibrillation From Shanghai

Conditions:   Atrial Fibrillation;   Left Atrial Appendage Occlusion
Intervention:   Device: left atrial appendage occlusion devices
Sponsor:   Shanghai 10th People's Hospital
Recruiting

A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men ( TRAVERSE )

Conditions:   Hypogonadism;   Cardiovascular Diseases
Interventions:   Drug: Testosterone;   Drug: Placebo
Sponsors:   AbbVie;   Acerus Pharmaceuticals Corporation;   Allergan Sales, LLC;   Endo Pharmaceuticals;   Upsher-Smith Laboratories
Recruiting

Edoxaban Versus Edoxaban With antiPlatelet Agent In Patients With Atrial Fibrillation and Chronic Stable Coronary Artery Disease

Conditions:   Atrial Fibrillation;   Coronary Artery Disease;   Stable Angina;   Stable Chronic Angina
Interventions:   Drug: Edoxaban;   Drug: Single Antiplatelet Agents
Sponsors:   Gi-Byoung Nam;   CardioVascular Research Foundation, Korea
Recruiting

Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Dialysis (ASCEND-D)

Condition:   Anaemia
Interventions:   Drug: Daprodustat;   Drug: rhEPO;   Drug: Placebo;   Drug: Iron therapy
Sponsor:   GlaxoSmithKline
Active, not recruiting

Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND)

Condition:   Anaemia
Interventions:   Drug: Daprodustat;   Drug: Darbepoetin alfa;   Drug: Placebo;   Drug: Iron Therapy
Sponsor:   GlaxoSmithKline
Recruiting

Effect of Efpeglenatide on Cardiovascular Outcomes

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Efpeglenatide (SAR439977);   Drug: Placebo
Sponsor:   Sanofi
Active, not recruiting

A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Advanced Prostate Cancer and Cardiovascular Disease

Condition:   Prostate Cancer
Interventions:   Drug: Degarelix;   Drug: Leuprolide
Sponsors:   Ferring Pharmaceuticals;   Memorial Sloan Kettering Cancer Center;   Duke Clinical Research Institute
Recruiting

Assessment of Brain Activity During Complex Fine Hand Movements: an fMRI Study

Conditions:   Regional Anaesthesia;   Functional Magnetic Resonance Imaging
Intervention:   Diagnostic Test: fMRI
Sponsor:   Akdeniz University
Recruiting

Strategies for the Management of Atrial Fibrillation in patiEnts Receiving HemoDialysis

Conditions:   Atrial Fibrillation;   End Stage Renal Failure on Dialysis
Interventions:   Drug: Warfarin;   Drug: Apixaban;   Other: No oral anticoagulation
Sponsors:   St. Michael's Hospital, Toronto;   Canadian Institutes of Health Research (CIHR)
Not yet recruiting

Aortic Valve Reconstruction Using Autologous Pericardium: Single Center Experience With the Ozaki Technique

Condition:   Aortic Valve Disease
Intervention:  
Sponsor:   University Hospital, Basel, Switzerland
Completed

This Study Observes the Usage of Non-vitamin K Antagonist Oral Anticoagulants (NOACs) in Elderly Patients With a Heart Rhythm Disorder in Spain

Condition:   Atrial Fibrillation
Intervention:   Drug: Non-vitamin K antagonist oral anticoagulant
Sponsor:   Boehringer Ingelheim
Not yet recruiting

Resistance Training and Neuroimaging

Conditions:   Cognitive Decline;   Cerebrovascular Function
Intervention:   Behavioral: Periodized Resistance Training
Sponsors:   Todd Schroeder;   Southern California Clinical and Translational Science Institute
Recruiting

Sildenafil To Prevent Clot

Conditions:   Thrombosis;   Hemolysis
Interventions:   Drug: Sildenafil;   Drug: Placebo Oral Tablet
Sponsor:   Montefiore Medical Center
Recruiting

Choline Alphoscerate-Nimodipine in Vascular Cognitive Impairment

Condition:   Vascular Cognitive Impairment
Interventions:   Drug: Choline alphoscerate;   Drug: Placebo
Sponsors:   Azienda Ospedaliero-Universitaria Careggi;   MDM S.p.A.
Active, not recruiting

Genetic Factors in Atherosclerosis

Condition:   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Completed

Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Subjects With Dialysis-dependent Chronic Kidney Disease (DD-CKD)

Condition:   Anemia in Subjects With DD-CKD
Interventions:   Drug: vadadustat;   Drug: darbepoetin alfa
Sponsor:   Akebia Therapeutics
Active, not recruiting

Efficacy and Safety Study to Evaluate Vadadustat for the Correction or Maintenance Treatment of Anemia in Subjects With Incident Dialysis-dependent Chronic Kidney Disease (DD-CKD)

Conditions:   Anemia;   Dialysis-dependent Chronic Kidney Disease
Interventions:   Drug: vadadustat;   Drug: Darbepoetin alfa
Sponsor:   Akebia Therapeutics
Active, not recruiting

Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Subjects With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)

Conditions:   Anemia;   Non-dialysis-dependent Chronic Kidney Disease
Interventions:   Drug: vadadustat;   Drug: darbepoetin alfa
Sponsor:   Akebia Therapeutics
Recruiting

Efficacy and Safety Study to Evaluate Vadadustat for the Correction of Anemia in Subjects With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)

Conditions:   Anemia;   Non-dialysis-dependent Chronic Kidney Disease
Interventions:   Drug: vadadustat;   Drug: darbepoetin alfa
Sponsor:   Akebia Therapeutics
Recruiting

Safety and Efficacy of the Symetis ACURATE Neo/TF Compared to the Edwards SAPIEN 3 Bioprosthesis.

Condition:   Aortic Valve Stenosis
Interventions:   Device: Symetis ACURATE neo/TF transfemoral TAVI system;   Device: Edwards Sapien 3 Transcatheter Heart Valve
Sponsors:   University Hospital Inselspital, Berne;   Kerckhoff Heart Center
Active, not recruiting

Capnogram and Fluid Responsiveness

Conditions:   Healthy;   Blood Pressure
Intervention:   Other: Passive leg raising
Sponsor:   Augusta University
Recruiting

Effects of Irrigation Activation on Clinical Outcomes of Root Canal Treatment

Conditions:   Periapical Periodontitis;   Root Canal Infection
Interventions:   Procedure: three irrigation activation methods;   Procedure: conventional needle irrigation
Sponsor:   Istanbul Medipol University Hospital
Completed

Statins Evaluation in Coronary Procedures and Revascularization Trial

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Atorvastatin;   Drug: Placebo
Sponsors:   Hospital do Coracao;   Ministry of Health, Brazil
Completed

Effects of Liothyronine on Energy Expenditure and Cardiovascular Function

Condition:   Healthy
Interventions:   Drug: Liothyronine;   Drug: Levothyroxine;   Drug: Placebos
Sponsor:   Virginia Commonwealth University
Recruiting

Safety of PZ-128 in Subjects Undergoing Non-Emergent Percutaneous Coronary Intervention

Conditions:   Arterial Occlusive Diseases;   Coronary Artery Disease;   Coronary Disease;   Arteriosclerosis;   Heart Diseases;   Myocardial Ischemia;   Vascular Diseases;   Acute Coronary Syndrome
Interventions:   Drug: PZ-128;   Drug: Placebo
Sponsors:   Tufts Medical Center;   National Heart, Lung, and Blood Institute (NHLBI);   RTI International;   Inova Fairfax Hospital;   University of Massachusetts, Worcester
Suspended

Nutrition Intervention Trials in Linxian Follow-up Study

Conditions:   Esophageal Cancer;   Gastric Cancer
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

Sarcopenic Obesity in Neurodisabilities

Conditions:   Sarcopenic Obesity;   Spinal Cord Injuries;   Stroke;   Multiple Sclerosis;   Traumatic Brain Injury
Intervention:   Diagnostic Test: whole body DXA
Sponsors:   Dionyssiotis, Yannis, M.D.;   University of Athens
Enrolling by invitation

Lithium Treatment for Patients With Spinocerebellar Ataxia Type I

Condition:   Spinocerebellar Ataxia Type I
Intervention:   Drug: Lithium Carbonate
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Characteristics of Parkinson s Disease Associated With the LRRK-2 Gene Mutation

Condition:   Parkinson Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated

Intrathecal (IT) Baclofen Drug Distribution

Condition:   Muscle Spasticity
Intervention:   Drug: Baclofen bolus injection
Sponsors:   Vanderbilt University;   Medtronic
Active, not recruiting

Cardiac Output Monitoring in Critically Ill Patient Undergoing Intubation

Condition:   Hypotension
Intervention:   Device: NICOM (Non invasive cardiac output monitor)
Sponsor:   Mayo Clinic
Recruiting

Management of Antiplatelet Regimen During Surgical Procedures

Conditions:   Cardiac Surgery;   Anti-Platelet Medication;   Bridging;   Percutaneous Coronary Intervention
Intervention:  
Sponsors:   University of Texas Southwestern Medical Center;   Chiesi Farmaceutici S.p.A.
Recruiting

Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD

Conditions:   Obstructive Sleep Apnea;   PTSD;   Posttraumatic Stress Disorder
Interventions:   Behavioral: CBT-OSA;   Behavioral: Sleep Education
Sponsor:   VA Office of Research and Development
Recruiting

Hypertension Chronobiome

Condition:   Hypertension
Intervention:   Other: Ambulatory blood pressure measurements
Sponsor:   University of Pennsylvania
Recruiting

Defining a PD-specific Breath Fingerprint of Underlying Inflammatory and Neurodegenerative Processes

Condition:   Parkinson's Disease
Interventions:   Other: Blood Sample Collection;   Other: Breath Sample Collection
Sponsors:   Emory University;   Michael J. Fox Foundation for Parkinson's Research
Completed

Peer Support for Women With Heart Disease: Women@Heart

Conditions:   Coronary Heart Disease;   Women's Health
Intervention:   Behavioral: Women@Heart Program
Sponsor:   Ottawa Heart Institute Research Corporation
Recruiting

Acute Vascular Effects of E-cigarette Use

Condition:   Healthy
Interventions:   Other: E-cigarette vapor containing nicotine;   Other: E-cigarette vapor, nicotine free
Sponsors:   Umeå University;   Karolinska Institutet
Active, not recruiting

Brilinta Clinical Experience Investigation

Condition:   Acute Coronary Syndrome, Old Myocardial Infarction
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Switch to Ticagrelor in Critical Limb Ischemia Anti-platelet Study

Condition:   Critical Limb Ischemia
Intervention:   Drug: Ticagrelor
Sponsor:   University of Southern California
Completed

Primary Aldosteronism and Surgically Curable Forms in Hypertension Patients Using 11C-Metomidate

Conditions:   Primary Aldosteronism;   Primary Aldosteronism Due to Aldosterone Producing Adenoma
Intervention:   Combination Product: 11C-Metomidate PET/CT Scan
Sponsors:   Changi General Hospital;   National University Health System, Singapore;   Clinical Imaging Research Centre;   Singapore General Hospital;   Tan Tock Seng Hospital;   Khoo Teck Puat Hospital;   Ng Teng Fong General Hospital
Recruiting

Balancing Risk: Red Blood Cell Transfusion Strategies In Cardiac Surgery

Condition:   Anemia
Interventions:   Procedure: Blood transfusion at hematocrit value less than 24%;   Procedure: Blood transfusion at hematocrit value less than 28%
Sponsor:   The Cleveland Clinic
Completed

Emotional Prosody Treatment in Parkinson's

Condition:   Parkinson Disease
Interventions:   Behavioral: Emotional prosodic treatment;   Behavioral: Standard prosodic treatment
Sponsor:   VA Office of Research and Development
Completed

Mindfulness-Based Therapy for Brain Tumour Survivors

Conditions:   Brain Tumour;   Depressive Symptoms;   Survivors
Intervention:   Behavioral: Mindfulness-based Therapy
Sponsors:   Sunnybrook Health Sciences Centre;   Brain Tumour Foundation of Canada
Completed

Communicating Multiple Disease Risks: A Translation of Risk Prediction Science

Condition:   Healthy Volunteers
Interventions:   Behavioral: Risk Display App;   Behavioral: Imagery Audio Recording - Sleep;   Other: Survey;   Behavioral: Imagery Audio Recording - Exercise;   Other: Text message reminders;   Other: Text Message Based Survey
Sponsors:   Washington University School of Medicine;   National Institutes of Health (NIH)
Completed

RNA Sequencing in the Framingham Heart Study Third Generation Cohort Exam 2

Conditions:   Cardiovascular Disease;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Role of PPAR-y Agonists in Immunomodulation and Vascular Prevention in SLE (PPAR-SLE)

Condition:   Systemic Lupus Erthematosus
Interventions:   Radiation: PET/CT;   Drug: Pioglitazone;   Procedure: Vascular function studies
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting

Randomized Study for the Optimal Treatment of Symptomatic Patients With Low Gradient Severe Aortic Valve Stenosis and Preserved Left Ventricular Ejection Fraction

Condition:   Aortic Valve Stenosis
Interventions:   Procedure: aortic valve replacement;   Other: strict clinical surveillance
Sponsor:   Rennes University Hospital
Recruiting

A Study to Observe the Effectiveness of Empagliflozin, Other SGLT-2 Inhibitors, or DPP-4 Inhibitors in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Subjects treated with Empagliflozin or any Sodium-glucose cotransporter-2 (SGLT-2) inhibitor;   Drug: Subjects treated with Dipeptidyl peptidase-4 (DPP-4) inhibitor
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes

Condition:   Diabetes Type 2
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Elite Controller and ART-treated HIV+ Statin Versus ASA Treatment Intervention Study

Condition:   Human Immunodeficiency Virus
Interventions:   Drug: Aspirin;   Drug: Lipitor
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Active, not recruiting

Insulin Resistance and Atherosclerosis in Women With Lupus

Conditions:   Systemic Lupus Erythematosus;   Insulin Resistance;   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Completed

Neurocognitive Empowerment for Addiction Treatment (NEAT) in Opioid Use Disorder and Amphetamine Use Disorder

Conditions:   Opioid-use Disorder;   Amphetamine Use Disorders
Interventions:   Behavioral: Neurocognitive Empowerment for Addiction Treatment (NEAT);   Behavioral: Active Control
Sponsors:   Laureate Institute for Brain Research, Inc.;   Oklahoma Center for the Advancement of Science and Technology
Recruiting

A Problem Solving Intervention for Post-ICU Cognitive Impairment in Older Adults

Conditions:   Critical Illness;   Mechanical Ventilation Complication;   Delirium;   Cognitive Impairment
Intervention:   Behavioral: Post-ICU Problem Solving
Sponsor:   Ohio State University
Not yet recruiting

Mobility Training to Improve Motor Behavior in Toddlers With or at Risk for Cerebral Palsy: A Pilot Study

Conditions:   Developmental Delay;   Cerebral Palsy
Intervention:   Behavioral: mobility training with dynamic body weight support
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed

Effect of Diet on Vascular Disease in Pre-Menopausal Women

Conditions:   Cardiovascular Diseases;   Vascular Disease;   Inflammation;   Insulin;   Triglycerides
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Trial to Assess Chelation Therapy in Critical Limb Ischemia

Conditions:   Critical Limb Ischemia;   Diabetes
Interventions:   Drug: Edetate Disodium;   Other: Placebo
Sponsor:   Mt. Sinai Medical Center, Miami
Recruiting

Skin Sympathetic Nerve Activity and Cardiac Arrhythmias

Condition:   Sympathetic Nerve Activity
Intervention:   Other: Physiologic maneuvers
Sponsors:   Cedars-Sinai Medical Center;   National Institutes of Health (NIH)
Withdrawn

Xarelto [SPAF] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban(Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia

Conditions:   Sickle Cell Disease;   Chronic Kidney Disease;   Pulmonary Hypertension
Intervention:   Drug: Erythropoietin and Hydroxyurea
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Diagnosis of Pheochromocytoma

Conditions:   Pheochromocytoma;   Endocrine Disease;   Endocrine Diseases
Interventions:   Drug: Fluorodopamine;   Drug: F-18 Fluorodopa
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Social-software iMproving wARfarin Therapy

Conditions:   Anticoagulants Causing Adverse Effects in Therapeutic Use;   Patient Compliance
Intervention:   Behavioral: Social-software management
Sponsor:   Wuhan Asia Heart Hospital
Completed

Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients

Conditions:   Frail Elderly;   Coronary Artery Disease
Interventions:   Procedure: Off-pump coronary-artery bypass grafting;   Procedure: On-pump coronary-artery bypass grafting
Sponsors:   University of Sao Paulo General Hospital;   Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina de São Paulo;   Instituto de Cardiologia do Distrito Federal;   Hospital Alberto Urquiza Wanderley;   Hospital das Clínicas Samuel Libânio;   Pontifícia Universidade Católica do Paraná;   Hospital Samaritano Paulista;   Beneficência Portuguesa de São Paulo;   Hospital Samaritano Campinas;   Mount Sinai Hospital, New York
Recruiting

Naloxegol US PMR CV Safety.

Condition:   Opioid Induced Constipation
Interventions:   Drug: naloxegol;   Drug: non-PAMORA
Sponsor:   AstraZeneca
Recruiting

Comparative Effectiveness of Empagliflozin in the US

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Empagliflozin;   Drug: DPP-4 inhibitor
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting

Aclidinium Bromide Post-Authorisation Safety Study to Evaluate the Risk of Cardiovascular Endpoints

Condition:   Pulmonary Disease, Chronic Obstructive
Interventions:   Drug: Aclidinium bromide;   Drug: Other COPD medication
Sponsors:   AstraZeneca;   RTI Health Solutions
Recruiting

mDASHNa-CC APP to Support a Healthy Diet and Hypertension Control for Chinese Canadian Seniors

Conditions:   Hypertension;   Diet, Healthy
Intervention:   Device: mDASHNa App
Sponsor:   University of Toronto
Not yet recruiting

The ENROUTE Transcarotid Neuroprotection System (ENROUTE Transcarotid NPS) DW-MRI Evaluation

Conditions:   Carotid Artery Diseases;   Carotid Atherosclerosis;   Carotid Stenosis;   Carotid Artery Plaque;   Carotid Disease
Intervention:   Procedure: Transcarotid Revascularization (TCAR)
Sponsors:   Silk Road Medical;   Indiana University;   University of Navarra;   Stanford University
Not yet recruiting

Neurological Effects of Goal-directed Fluid Therapy in Beach Chair Position Shoulder Surgery

Conditions:   Postoperative Cognitive Dysfunction;   Anesthesia
Interventions:   Procedure: Goal-directed fluid therapy;   Procedure: Non goal-directed fluid therapy
Sponsor:   National Taiwan University Hospital
Not yet recruiting

Efficacy of Massage for the Treatment of Cancer-Related Fatigue (CRF) in Prostate Cancer Survivors

Condition:   Cancer-related Problem/Condition
Interventions:   Other: Swedish Massage Therapy;   Other: Light Touch Intervention
Sponsor:   Emory University
Completed

Endurant CHevAr New Indication Trial: ENCHANT

Condition:   AAA - Abdominal Aortic Aneurysm
Intervention:   Device: Endurant Chimney Graft Technique
Sponsor:   Medtronic Endovascular
Recruiting

G-EO Gait Rehabilitation Training in Progressive Multiple Sclerosis

Condition:   Progressive Multiple Sclerosis
Interventions:   Device: G-EO System (Reha Technology AG: Olten, Switzerland);   Other: Conventional Physical Therapy
Sponsors:   Indiana University;   University of Alabama at Birmingham;   University of Ottawa
Recruiting

CTO Registry From Insight of IVUS in Fuwai Hospital

Conditions:   Coronary Heart Disease;   Chronic Total Occlusion of Coronary Artery;   Percutaneous Coronary Intervention;   Intravascular Ultrasound
Intervention:  
Sponsor:   China National Center for Cardiovascular Diseases
Recruiting

EVAS2 IDE Prospective, Multicenter, Single Arm Safety and Effectiveness Confirmatory Study

Condition:   Abdominal Aortic Aneurysm Without Rupture
Intervention:   Device: Nellix® System
Sponsor:   Endologix
Recruiting

International Active Surveillance Study - Safety of Contraceptives: Role of Estrogens

Condition:   Contraception
Intervention:  
Sponsors:   Center for Epidemiology and Health Research, Germany;   Bayer Healthcare Pharmaceuticals, Inc./Bayer Schering Pharma
Completed

Thoracoabdominal Aortic and Aortic Arch Aneurysms With Fenestrated and Branched Stent Grafts

Conditions:   Thoracoabdominal Aortic Aneurysm;   Aortic Arch Aneurysm
Interventions:   Device: Thoracoabdominal Aortic Aneurysm Arm;   Device: Aortic Arch Aneurysm Arm
Sponsors:   Gustavo S. Oderich;   William Cook Australia
Recruiting

Quality and Safety of Initial Management for ST-segment Elevation Myocardial Infarction

Condition:   Myocardial Infarction
Intervention:   Other: Daily practice care for patients with suspected of STEMI
Sponsors:   Centre Hospitalier de la Région d'Annecy;   University Hospital, Grenoble
Recruiting

MOMENTUM 3 IDE Clinical Study Protocol

Condition:   Advanced Refractory Left Ventricular Heart Failure
Interventions:   Device: HeartMate 3 LVAS;   Device: HeartMate II LVAS
Sponsors:   Abbott Medical Devices;   Thoratec Corporation
Completed

Comparison One vs Six Months of Dual Antiplatelet Therapy After Implanted Firehawk TM Stent in High Bleeding Risk Patients With Coronary Artery Disease

Conditions:   Coronary Disease;   Drug Eluting Stent;   Percutaneous Coronary Intervention;   Dual Antiplatelet Therapy
Interventions:   Drug: 1 month DAPT;   Drug: 6 months DAPT
Sponsor:   Shanghai MicroPort Medical (Group) Co., Ltd.
Recruiting

Comparison Three vs Twelve Months of Dual Anti-Platelet Therapy After Stent Implantation

Conditions:   Drug-Eluting Stents;   Percutaneous Coronary Intervention
Interventions:   Drug: 3 months DAPT;   Drug: 12 months DAPT
Sponsor:   Shanghai MicroPort Medical (Group) Co., Ltd.
Recruiting

Antiplatelet Therapy in Acute Coronary Syndrome(ACS). Safety and Efficacy of Switching Antiplatelet

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   Fundación Pública Andaluza Progreso y Salud
Active, not recruiting

INAS-FOCUS (International Active Surveillance Study - Folate in Oral Contraceptives Utilization Study)

Condition:   Contraception
Intervention:  
Sponsors:   Center for Epidemiology and Health Research, Germany;   Bayer
Active, not recruiting

Clinical Decision Support for Patient Migraine Management

Condition:   Migraine
Interventions:   Behavioral: Clinical Decision Support Tool;   Behavioral: Headache Education
Sponsors:   Albert Einstein College of Medicine;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Noninvasive VNS for Neuromotor Adaptations

Condition:   Healthy Young Adults
Intervention:   Other: tVNS
Sponsors:   Georgia Institute of Technology;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Natural History of Multiple Sclerosis and Its Mimickers

Conditions:   Neurologic Disorders;   Healthy Volunteers;   Multiple Sclerosis
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Cephea Transseptal Mitral Valve System FIH

Condition:   Mitral Regurgitation
Intervention:   Device: Transcatheter Mitral Valve Replacement via Transseptal Access
Sponsor:   Cephea Valve Technologies
Recruiting

Relating Genetic and Environmental Risk Scores to Multiple Sclerosis Susceptibility

Condition:   Multiple Sclerosis
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Fluorescence Guided Resection of Brain Tumors

Condition:   Brain Tumors
Intervention:   Drug: 5-aminolevulinic acid
Sponsors:   David W. Roberts;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

A Multicenter, Randomized, Placebo-controlled Study

Condition:   Prolonged DAPT in ACS Patients With Hisk of Both Ischemic and Hemorrhage
Interventions:   Drug: Clopidogrel;   Drug: Clopidogrel+aspirin
Sponsor:   Shenyang Northern Hospital
Recruiting

Fixed Versus Variable Dosing of 4-factor Prothrombin Complex Concentrate for Emergent Warfarin Reversal

Conditions:   Acute Bleeding on Long-Term Anticoagulation Therapy;   Hemorrhage;   Significant Bleeding in Patients With a Coagulopathy (Prolonged Thrombin Time);   Urgent Reversal of Vitamin K Antagonist (VKA) Anticoagulation
Intervention:   Drug: 4-factor prothrombin complex concentrate (4FPCC)
Sponsor:   HealthPartners Institute
Completed

Characteristics of Patients With Type 2 Diabetes Mellitus (CVD-RNDR)

Condition:   Type 2 Diabetes
Intervention:  
Sponsor:   AstraZeneca
Completed

Active Surveillance Research Program for the Assessment of the Safety and the Effectiveness of Linagliptin

Condition:   Diabetes Mellitus, Type 2
Intervention:  
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Completed

Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk

Condition:   Hypoxic-Ischemic Encephalopathy
Interventions:   Device: nfant feeding solution;   Device: Waveguard (TM) EEG cap;   Device: BabyMEG
Sponsors:   Boston Children’s Hospital;   Beth Israel Deaconess Medical Center;   Winchester Hospital
Recruiting

Randomized Trial of TAVI vs. SAVR in Patients With Severe Aortic Valve Stenosis at Intermediate Risk of Mortality

Condition:   Aortic Valve Stenosis
Interventions:   Device: Transcatheter aortic valve implantation;   Procedure: Surgical aortic valve replacement
Sponsors:   Universitätsklinikum Hamburg-Eppendorf;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)
Recruiting

Impact of nrTMS Therapy on the Progress of Neurorehabilitation

Condition:   Transcranial Magnetic Stimulation, Repetitive
Interventions:   Device: navigated repetitive transcranial magnetic stimulation;   Procedure: physical therapy
Sponsor:   Technische Universität München
Recruiting

Investigating the Effects of Cardiac Rehabilitation eXercise Modalities on Physical and Mental Health Outcomes

Condition:   Coronary Artery Disease (CAD)
Interventions:   Behavioral: High Intensity Interval Training;   Behavioral: Moderate Intensity Continuous Exercise Training;   Behavioral: Nordic Walking
Sponsors:   Ottawa Heart Institute Research Corporation;   Ontario Ministry of Health and Long Term Care;   Heart and Stroke Foundation of Canada
Active, not recruiting

Computed Tomography Screening for Early Lung Cancer, COPD and Cardiovascular Disease in Shanghai, China

Conditions:   Lung Neoplasms;   Mass Screening;   Chronic Obstructive Pulmonary Disease;   Cardiovascular Disease
Interventions:   Other: Low-dose CT screening with quantitative assessment and management of imaging biomarkers;   Other: Low-dose CT screening with visual assessment and management of imaging biomarkers
Sponsor:   Shanghai Changzheng Hospital
Recruiting

Occupational Self-Analysis Programme

Conditions:   Occupational Therapy;   Intellectual Disability;   Acquired Brain Injury;   Students;   Stroke;   Awareness
Interventions:   Behavioral: Occupational self-analysis;   Behavioral: Vocational guidance;   Behavioral: Usual Rehabilitation
Sponsors:   University of Malaga;   Universidad Católica San Antonio de Murcia
Completed

Neurophysiologically Based Brain State Tracking and Modulation in Focal Epilepsy

Condition:   Epilepsy
Intervention:   Device: Medtronic Summit System, Olympus
Sponsors:   Mayo Clinic;   National Institute of Neurological Disorders and Stroke (NINDS);   Medtronic
Recruiting

Diagnostic Performance of Fluorescein as an Intraoperative Brain Tumor Biomarker

Condition:   Brain Cancer
Interventions:   Drug: Fluorescein;   Drug: Fluorescein + ALA
Sponsors:   David W. Roberts;   National Institute of Neurological Disorders and Stroke (NINDS);   Carl Zeiss Meditec, Inc.
Recruiting

Tolerability, Safety, and Activity of SRX246 in Irritable Subjects With Huntington's Disease

Conditions:   Irritable Mood;   Huntington's Disease
Interventions:   Drug: SRX246;   Drug: Placebo
Sponsors:   Azevan Pharmaceuticals;   National Institute of Neurological Disorders and Stroke (NINDS);   NeuroNEXT Network
Completed

Clinical Outcomes for Deep Brain Stimulation

Conditions:   Parkinson Disease;   Essential Tremor;   Dystonia
Intervention:   Device: Deep Brain Stimulation
Sponsors:   Washington University School of Medicine;   National Institute for Biomedical Imaging and Bioengineering (NIBIB);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Recovery of Consciousness Following Intracerebral Hemorrhage

Condition:   Intra Cerebral Hemorrhage
Intervention:  
Sponsors:   Columbia University;   Pitié-Salpêtrière Hospital;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

A Wireless EEG Patch for Continuous Electrographic Monitoring

Condition:   Epilepsy
Intervention:   Device: N/A Observational only
Sponsors:   Epitel, Inc.;   Boston Children’s Hospital;   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation

Early Biomarkers of Autism in Infants With Tuberous Sclerosis Complex (TSC)

Condition:   Tuberous Sclerosis Complex
Intervention:  
Sponsors:   Boston Children’s Hospital;   National Institute of Neurological Disorders and Stroke (NINDS);   Tuberous Sclerosis Alliance
Active, not recruiting

Responsive Deep Brain Stimulator for Essential Tremor

Condition:   Essential Tremor
Interventions:   Device: Deep brain stimulation;   Device: Closed-loop deep brain stimulation
Sponsors:   University of Florida;   Medtronic;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Maternal and Neurodevelopmental Outcomes of in Utero Antiepileptic Drug (AED) Exposure

Conditions:   Epilepsy;   Pregnancy
Intervention:  
Sponsors:   Stanford University;   The Emmes Company, LLC;   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting

Management of Paroxystic Atrial Fibrillation in French Intensive Care Units

Conditions:   New Onset Atrial Fibrillation;   ICU Patients
Intervention:  
Sponsors:   University Hospital, Clermont-Ferrand;   French Society of Anesthesia and Intensive Care Medecine
Recruiting

Assisted Fluid Management In Patients Undergoing Major Abdominal and Orthopedic Surgery

Condition:   Monitoring
Intervention:   Other: Use of a decision support system on the EV1000 monitoring (AFM mode)
Sponsor:   Assistance Publique - Hôpitaux de Paris
Not yet recruiting

Effect of Aldosterone on Energy Starvation in Heart Failure

Conditions:   Heart Failure;   Nonischemic Dilated Cardiomyopathy
Intervention:   Drug: spironolactone
Sponsor:   Vanderbilt University
Completed

Fentanyl and Crushed Ticagrelor in Percutaneous Coronary Intervention

Condition:   Percutaneous Coronary Intervention
Interventions:   Drug: Fentanyl;   Drug: Ticagrelor 90Mg Tablet
Sponsor:   The Guthrie Clinic
Recruiting

Hemodynamic Parameters Changes in the Course of Hemodialysis Sessions in Patients With Intradialytic Hypertension

Condition:   Intradialytic Hypertension
Intervention:  
Sponsor:   Western Galilee Hospital-Nahariya
Completed

Controlled MAP Trauma Brain Injury (COMAT Study)

Condition:   Traumatic Brain Injury
Intervention:   Device: EV1000 and closed-loop system
Sponsors:   Assistance Publique - Hôpitaux de Paris;   University of California, Los Angeles;   University of California, Irvine
Not yet recruiting

Drug-Eluting Stents vs. Bare Metal Stents In Saphenous Vein Graft Angioplasty

Condition:   Saphenous Vein Graft Atherosclerosis
Interventions:   Device: Bare Metal Stent;   Device: Drug-Eluting Stent;   Drug: Blinded clopidogrel;   Drug: Placebo;   Drug: Thienopyridine (open-label)
Sponsor:   VA Office of Research and Development
Completed

Study to Develop a Prediction Model to Understand the Effect of Low-dose Aspirin on Cancer That Develops in the Colon and/or the Rectum, Diseases That Affects the Heart or Blood Vessels and Safety Outcomes in European Countries. The Study is Also Called PEACOS Model EU

Conditions:   Colorectal Cancer;   Cardiovascular Disease;   Bleeding
Intervention:   Drug: Acetylsalicylic Acid (Aspirin, BAYE4465)
Sponsor:   Bayer
Active, not recruiting

EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality

Conditions:   Atrial Fibrillation;   Coronary Heart Disease;   Cardiovascular Diseases;   Heart Failure;   Hypertension;   Peripheral Arterial Disease;   Stroke, Ischemic;   Asthma;   Chronic Obstructive Pulmonary Disease;   Obesity;   Cancer;   Chronic Kidney Diseases;   Diabetes Mellitus;   Dementia;   Depression;   Epilepsy;   Mental Health Disorder;   Rheumatoid Arthritis;   Blood Pressure
Intervention:  
Sponsor:   Future Genetics Limited
Not yet recruiting

Transplantation Using Reduced Intensity Approach for Patients With Sickle Cell Disease From Mismatched Family Donors of Bone Marrow

Condition:   Sickle Cell Disease
Interventions:   Procedure: Bone Marrow Transplant (BMT);   Procedure: Bone Marrow Harvest (Donation);   Drug: Hydroxyurea;   Drug: Thiotepa;   Drug: Fludarabine monophosphate;   Drug: Cyclophosphamide;   Other: Rabbit Anti-thymocyte Globulin;   Radiation: Total Body Irradiation
Sponsor:   Emory University
Recruiting

A Pilot Study of Vitamin D in Boys With X-linked Adrenoleukodystrophy

Condition:   X-linked Adrenoleukodystrophy
Intervention:   Dietary Supplement: vitamin D3
Sponsors:   Stanford University;   National Institute of Neurological Disorders and Stroke (NINDS);   Hugo W. Moser Research Institute at Kennedy Krieger, Inc.;   ALD Connect, Inc.
Recruiting

Stimulation Of the Left Ventricular Endocardium for Cardiac Resynchronization Therapy in Non-Responders and Previously Untreatable Patients (SOLVE CRT)

Condition:   Heart Failure
Intervention:   Device: WiSE System
Sponsor:   EBR Systems, Inc.
Recruiting

Closed Loop DBS Implanted RC+S Study

Condition:   Parkinson Disease
Interventions:   Device: STN alone;   Device: GPi alone;   Device: STN + GPi;   Device: Closed-loop stimulation
Sponsors:   Dennis Turner, M.D.;   National Institutes of Health (NIH);   Duke University;   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Speed of Processing Training in Traumatic Brain Injury

Conditions:   Traumatic Brain Injury;   Vascular Accident, Brain
Interventions:   Other: Brain Fitness Program;   Other: Weekly Telephone Contact
Sponsor:   NYU Langone Health
Active, not recruiting

Neural Control of Kidney Blood Flow During Exercise in Black Adults

Condition:   Acute Exercise
Interventions:   Other: Acute exercise;   Other: Cold pressor test;   Other: Mental stress test
Sponsor:   University of Massachusetts, Boston
Not yet recruiting

Bioprosthetic or Native Aortic Scallop Intentional Laceration to Prevent Iatrogenic Coronary Artery Obstruction (BASILICA) Prospective Investigation

Condition:   Aortic Valve Failure
Intervention:   Device: ASHI_INTECC Astato XS 20 0.014 guidewire
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

The CONFIDENCE Registry

Conditions:   Symptomatic Degenerative Aortic Stenosis;   Severe Aortic Stenosis
Intervention:   Device: Portico™ Valve, Delivery System(s) and Loading Systems(s)
Sponsor:   Abbott Medical Devices
Recruiting

The ENROUTE Transcarotid Neuroprotection System (ENROUTE Transcarotid NPS) DW-MRI Study

Conditions:   Carotid Stenosis;   Carotid Artery Diseases;   Carotid Atherosclerosis;   Carotid Artery Plaque
Intervention:   Procedure: Carotid revascularization
Sponsors:   Silk Road Medical;   Complejo Hospitalario Toledo;   University Ghent;   Technische Universität München
Recruiting

A Novel Healthcare Information Technology Tool to Improve Care in Patients With Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:  
Sponsors:   University of California, San Diego;   Biosense Webster, Inc.
Recruiting

Anticoagulant Versus Dual Antiplatelet Therapy for Preventing Leaflet Thrombosis and Cerebral Embolization After Transcatheter Aortic Valve Replacement

Condition:   Aortic Valve Stenosis
Interventions:   Drug: NOAC;   Drug: DAPT
Sponsors:   Duk-Woo Park, MD;   CardioVascular Research Foundation, Korea;   Daiichi Sankyo Korea Co., Ltd.
Recruiting

Safety and Efficacy of THN102 in Patients With Parkinson's Disease and Excessive Daytime Sleepiness

Condition:   Parkinson Disease
Interventions:   Drug: THN102 Dosage A;   Drug: THN102 Dosage B;   Drug: THN102 Dosage C
Sponsor:   Theranexus
Recruiting

Water Immersion in Chronic Stable Heart Failure

Condition:   Heart Failure
Intervention:   Other: water immersion
Sponsor:   Hull and East Yorkshire Hospitals NHS Trust
Completed

Tragus Stimulation to Prevent Atrial Fibrillation After Cardiac Surgery

Condition:   Atrial Fibrillation
Intervention:   Device: Parasym
Sponsors:   University of Chicago;   Parasym Ltd.
Recruiting

Assessment of Arrhythmias in Patients Undergoing Transcatheter Aortic Valve Implantation Using a Small Insertable Cardiac Monitoring Device

Condition:   Aortic Valve Stenosis
Intervention:  
Sponsor:   University Hospital Inselspital, Berne
Recruiting

Protection During Cardiac Surgery.

Conditions:   Thoracic Surgery;   Cardiopulmonary Bypass
Interventions:   Other: multimodal cardioprotection strategy;   Other: standard anesthetic procedure
Sponsor:   Hospices Civils de Lyon
Completed

Hybrid Exercise Training for Health, Performance and Well-Being (DoIT II)

Conditions:   High-Intensity Interval Training;   Body Composition;   Performance;   Habitual Physical Activity
Interventions:   Behavioral: DoIT-1;   Behavioral: DoIT-2;   Behavioral: DoIT-3;   Behavioral: Control
Sponsor:   University of Thessaly
Not yet recruiting

Assessing the Safety and Performance of the easyEndoTM Universal Linear Cutting Stapler in Laparoscopic Gastric Bypass Surgery

Conditions:   Roux-en-Y Gastric Bypass;   Obesity
Intervention:   Device: easyEndoTM Universal Linear Cutting Stapler and reloads (Ezisurg Medical)
Sponsor:   Duomed
Not yet recruiting

A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

Study of rADAMTS-13 (SHP655) in the Treatment of Participants With Acquired Thrombotic Thrombocytopenic Purpura (aTTP)

Condition:   Acquired Thrombotic Thrombocytopenic Purpura (aTTP)
Interventions:   Other: Placebo;   Drug: SHP655;   Other: Standard of Care
Sponsor:   Shire
Not yet recruiting

This Study Looks at the Effects of Idarucizumab in Patients Who Take Dabigatran and Need Emergency Surgery or Are Bleeding

Condition:   Atrial Fibrillation
Intervention:   Drug: Idarucizumab
Sponsor:   Boehringer Ingelheim
Recruiting

Renal Artery Denervation In Addition to Catheter Ablation To Eliminate Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Hypertension
Interventions:   Procedure: catheter ablation;   Procedure: renal sympathetic denervation
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Completed

Family Habit Physical Activity Study

Condition:   Physical Activity
Interventions:   Behavioral: Family Physical Activity Planning;   Behavioral: Family Physical Activity Habit Formation
Sponsors:   University of Victoria;   Heart and Stroke Foundation of Canada;   University of British Columbia;   Dalhousie University;   University of Alberta;   King's College London
Recruiting

Natural History Study of Individuals With Autism and Germline Heterozygous PTEN Mutations

Conditions:   PTEN;   ASD;   Autism;   Macrocephaly;   PTEN Hamartoma Tumor Syndrome
Intervention:  
Sponsors:   Boston Children’s Hospital;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   Office of Rare Diseases (ORD);   National Center for Advancing Translational Science (NCATS);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting

Glutamate for Metabolic Intervention in Coronary Surgery

Conditions:   Coronary Artery Bypass;   Myocardial Ischemia;   Myocardial Infarction;   Coronary Artery Disease
Interventions:   Drug: Intravenous infusion of saline;   Other: Intravenous glutamate infusion
Sponsors:   University Hospital, Linkoeping;   Region Örebro County;   Blekingesjukhuset, Karlskrona
Completed

Conscious Sedation vs General Anesthesia in TAVR Patients

Condition:   Aortic Stenosis
Interventions:   Procedure: General Anesthesia;   Procedure: Conscious Sedation
Sponsor:   Montefiore Medical Center
Withdrawn

CHANGE Neo™ TA Registry With ACURATE Neo™ Aortic Bioprosthesis and ACURATE Neo™ TA Transapical Delivery System

Condition:   Aortic Stenosis
Intervention:   Device: ACURATE neo™ Aortic Bioprosthesis
Sponsor:   Symetis SA
Recruiting

Screening for Hereditary Transthyretin Related Amyloidosis - an Internationales, Multicentre, Epidemiological Protocol (TRAM)

Conditions:   Transthyretin Amyloidosis;   Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy;   Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy;   Polyneuropathies;   Cardiomyopathies
Intervention:  
Sponsor:   Centogene AG Rostock
Recruiting

A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)

Condition:   Multiple Sclerosis, Relapsing-Remitting
Intervention:   Biological: Ocrelizumab
Sponsor:   Hoffmann-La Roche
Active, not recruiting

Vision Testing in Patients With Partial Seizures Receiving Either Lyrica or Placebo

Condition:   Epilepsies, Partial
Interventions:   Drug: Lyrica (pregabalin);   Drug: placebo
Sponsor:   Pfizer
Recruiting

MOMENTUM 3 Pivotal Cohort Extended Follow-up PAS

Condition:   Advanced Refractory Left Ventricular Heart Failure
Intervention:   Device: HM3 LVAS
Sponsor:   Abbott Medical Devices
Enrolling by invitation

A Dose-response Study of Tranexamic Acid in Total Hip Arthroplasty

Condition:   Arthropathy of Hip
Interventions:   Drug: Placebo;   Drug: Group 1: perfusion of 500 mg Exacyl;   Drug: Group 2: perfusion of 1000 mg Exacyl;   Drug: Group 3: perfusion of 1500 mg Exacyl;   Drug: Group 4: perfusion of 3000 mg Exacyl
Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
Not yet recruiting

Delayed Cerebral Ischaemia and Coagulation Alterations After Aneurysmal Subarachnoid Haemorrhage

Condition:   Aneurysmal Subarachnoid Hemorrhage
Interventions:   Device: ROTEM;   Procedure: EEG;   Procedure: bilateral compression ultrasound of the lower extremity veins
Sponsor:   Tampere University Hospital
Recruiting

Comparison of Optical Coherence Tomography-derived Minimal Lumen Area, Invasive Fractional Flow Reserve and FFRCT

Condition:   Coronary Stenosis
Intervention:   Diagnostic Test: OCT, FFR, CTA and FFRCT
Sponsor:   University Hospital Inselspital, Berne
Recruiting

A Registry for Patients With Chronic Hypoparathyroidism

Condition:   Chronic Hypoparathyroidism
Intervention:   Drug: Combination product (Natpara) and drug or supplements [Disease and drug registry]
Sponsor:   Shire
Recruiting

Computed Tomography Coronary Angiography for the Prevention of Myocardial Infarction (The SCOT-HEART 2 Trial)

Condition:   Cardiovascular Diseases
Interventions:   Diagnostic Test: Computed tomography coronary angiography;   Other: ASSIGN Score
Sponsors:   University of Edinburgh;   British Heart Foundation;   NHS Lothian
Not yet recruiting

Dialysis Training Therapy: The DiaTT Trial

Conditions:   Chronic Kidney Diseases;   Hemodialysis
Interventions:   Behavioral: Intradialytic exercise intervention;   Behavioral: Usual Care
Sponsors:   Prof. Dr. med. Martin Halle;   Technische Universität München;   University Hospital of Cologne;   KfH Kuratorium für Dialyse und Nierentransplantation;   Clinical Trials Unit Freiburg;   AOK PLUS;   BARMER;   Techniker Krankenkasse;   Federal Joint Committee, Germany
Recruiting

TAPS2 Transfusion Antenatally in Pregnant Women With SCD

Conditions:   Sickle Cell Disease;   Pregnancy, High Risk;   Blood Transfusion Complication
Intervention:   Biological: Serial prophylactic exchange blood transfusion (SPEBT).
Sponsors:   Guy's and St Thomas' NHS Foundation Trust;   King's College Hospital NHS Trust;   Barts & The London NHS Trust;   The Whittington Hospital NHS Trust;   St Mary's NHS Trust;   University College London Hospitals;   St George's University Hospitals NHS Foundation Trust;   London School of Hygiene and Tropical Medicine;   King's College London;   University of Southampton
Not yet recruiting

Bivalirudin With Prolonged Full Dose Infusion Versus Heparin Alone During Emergency PCI

Condition:   ST Elevation Myocardial Infarction
Interventions:   Drug: Bivalirudin;   Drug: unfractionated Heparin
Sponsor:   Shenyang Northern Hospital
Recruiting

Mapping the Genotype, Phenotype, and Natural History of Phelan-McDermid Syndrome

Conditions:   Phelan-McDermid Syndrome;   Autism Spectrum Disorder;   Intellectual Disability
Intervention:  
Sponsors:   Boston Children’s Hospital;   National Institute of Neurological Disorders and Stroke (NINDS);   National Institutes of Health (NIH);   Office of Rare Diseases (ORD);   National Center for Advancing Translational Science (NCATS);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   Phelan-McDermid Syndrome Foundation
Active, not recruiting

IV Iron Replacement for Iron Deficiency in Idiopathic Pulmonary Arterial Hypertension (IPAH) Patients

Conditions:   Pulmonary Arterial Hypertension;   Iron Deficiency
Interventions:   Drug: Saline;   Drug: Ferinject or CosmoFer
Sponsors:   Imperial College London;   Fu Wai Hospital, Beijing, China
Completed

Anemia Studies in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat in Non-Dialysis Subjects Evaluating Hemoglobin (Hgb) and Quality of Life (ASCEND-NHQ)

Condition:   Anaemia
Interventions:   Drug: Daprodustat (GSK1278863);   Drug: Placebo;   Drug: Iron therapy
Sponsor:   GlaxoSmithKline
Recruiting

World Maternal Antifibrinolytic Trial_2

Condition:   Intrapartum - Moderate and Severe Anaemia
Interventions:   Drug: Tranexamic Acid;   Other: Placebo
Sponsors:   London School of Hygiene and Tropical Medicine;   Wellcome Trust;   Bill and Melinda Gates Foundation
Not yet recruiting

Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex (TSC)

Conditions:   Tuberous Sclerosis;   Autism Disorder;   Intellectual Disability
Intervention:  
Sponsors:   Boston Children’s Hospital;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   Tuberous Sclerosis Alliance;   National Center for Advancing Translational Science (NCATS);   Office of Rare Diseases (ORD);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Active, not recruiting

PRehabilitiation in Elective Frail and Elderly Cardiac Surgery PaTients

Conditions:   Coronary Artery Disease;   Valvular Heart Disease
Interventions:   Behavioral: PREHAB Workshop;   Behavioral: PREHAB Exercise Program
Sponsor:   Ottawa Heart Institute Research Corporation
Withdrawn

Neurofeedback in Alzheimer's Disease

Condition:   Alzheimer Disease
Intervention:   Behavioral: Neurofeedback
Sponsors:   Oregon Health and Science University;   National Institutes of Health (NIH);   National Institute on Deafness and Other Communication Disorders (NIDCD)
Recruiting

Improving Self-care of Heart Failure Caregivers

Condition:   Heart Failure
Intervention:   Behavioral: ViCCY
Sponsor:   University of Pennsylvania
Not yet recruiting

A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Hospitalized Participants With Influenza A Infection

Condition:   Influenza A
Interventions:   Drug: Pimodivir 600 mg;   Drug: Placebo;   Other: SOC Treatment
Sponsor:   Janssen Research & Development, LLC
Recruiting

Forearm Blood Flow in Chronic Kidney Disease Subjects With Anemia (FBF-CKD)

Condition:   Anaemia
Interventions:   Drug: Daprodustat;   Drug: Darbepoetin alfa (Aranesp);   Drug: Acetylcholine;   Drug: Sodium nitroprusside;   Drug: L-N-monomethyl arginine citrate (L-NMMA)
Sponsor:   GlaxoSmithKline
Recruiting

Hips Screws or (Total) Hip Replacement for Undisplaced Femoral Neck Fractures in Elderly Patients (HipSTHeR)

Conditions:   Femoral Neck Fractures;   Undisplaced Fracture
Interventions:   Device: Arthroplasty;   Device: Internal Fixation
Sponsors:   Uppsala University;   The Swedish Research Council
Not yet recruiting

Effect of Evolocumab on Saphenous Vein Graft Patency Following Coronary Artery Bypass Surgery

Conditions:   Coronary Artery Bypass Graft Surgery;   Atherosclerosis;   Vein Occlusion
Interventions:   Drug: Evolocumab;   Other: Placebo
Sponsors:   St. Michael's Hospital, Toronto;   Applied Health Research Centre
Recruiting

Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics

Conditions:   Osteomyelitis;   Diabetes;   Amputation
Interventions:   Drug: Rifampin;   Drug: Riboflavin Placebo
Sponsor:   VA Office of Research and Development
Recruiting

Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

Conditions:   Obstructive Sleep Apnea of Adult;   Preeclampsia;   Obstetrical Complications
Interventions:   Device: Continuous Positive Airway Pressure;   Other: Sleep Hygiene Control
Sponsors:   The George Washington University Biostatistics Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Electroencephalography Guidance of Anesthesia

Condition:   Delirium
Intervention:   Device: a pragmatic EEG-guided anesthetic protocol
Sponsors:   Washington University School of Medicine;   National Institute on Aging (NIA)
Active, not recruiting

EVOlocumab for Early Reduction of LDL-cholesterol Levels in Patients With Acute Coronary Syndromes (EVOPACS)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Evolocumab 140 mg/mL;   Drug: Placebo
Sponsors:   University Hospital Inselspital, Berne;   Amgen;   University of Bern
Active, not recruiting