Stroke

Clinical Trial Finder

Many patients who have experienced a stroke are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Comparing Unimanual and Bimanual Mirror Therapy for Upper Limb Recovery Post Stroke

Conditions:   Cerebral Vascular Accident (CVA);   Stroke
Interventions:   Behavioral: Traditional Home Based Exercise Program;   Behavioral: Unimanual Home Based Mirror Therapy Program;   Behavioral: Bimanual Home Based Mirror Therapy Program
Sponsor:   New York University School of Medicine
Recruiting - verified May 2016

Mirror Therapy After Stroke: A Dosing Study

Condition:   Stroke
Interventions:   Behavioral: Mirror Box Therapy;   Behavioral: Sham Mirror Box Therapy
Sponsors:   Columbia University;   Helen Hayes Hospital
Not yet recruiting - verified May 2016

Impact of Remote Ischemic Postconditioning on Autonomic Function in Stroke Patients

Condition:   Ischemic Stroke
Interventions:   Procedure: remote ischemic postconditioning;   Procedure: sham remote ischemic postconditioning
Sponsor:   Guangzhou University of Traditional Chinese Medicine
Recruiting - verified May 2016

Exercise Intensity of a Walking Related Task-Oriented Exercise in Stroke Survivors

Condition:   Stroke
Intervention:   Procedure: Structured, Progressive, Task-oriented exercise program
Sponsor:   Mahidol University
Not yet recruiting - verified May 2016

Neuroform Atlas Stent for Intracranial Aneurysm Treatment

Condition:   Intracranial Aneurysm
Intervention:  
Sponsor:   Stryker Neurovascular
Not yet recruiting - verified May 2016

Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

Condition:   Multiple Sclerosis
Interventions:   Drug: Methylprednisolone;   Drug: Methylprednisolone
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified May 2016

Optimizing Walking Function of Stroke Survivors by a Task-Oriented Home Exercise Program

Condition:   Stroke
Interventions:   Procedure: Task-oriented home exercise;   Procedure: Usual Physiotherapy Care
Sponsors:   Mahidol University;   University of Medical Technology (Yangon) Myanmar;   National Rehabilitation Hospital, Myanmar;   Yangon General Hospital, Myanmar
Not yet recruiting - verified May 2016

Anticoagulants Comparative Benefit-risk Ratio in Real Life

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Completed - verified May 2016

Action Selection and Arm Rehabilitation After Stroke

Condition:   Stroke
Intervention:   Behavioral: Arm Training with Action Selection
Sponsor:   University of South Carolina
Recruiting - verified May 2016

HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen

Condition:   Sickle Cell Disease
Intervention:   Drug: Fludarabine monophosphate
Sponsor:   National Guard Health Affairs
Recruiting - verified May 2016

STAMCAR: A Prospective EC-IC Bypass Registry

Condition:   Carotid Occlusion
Intervention:   Procedure: EC-IC bypass
Sponsors:   Lahey Clinic;   American Association of Neurological Surgeons
Not yet recruiting - verified May 2016

Serotonin Selective Reuptake Inhibitor (SSRI) Effects on Cerebral Connectivity in Acute Ischemic Stroke

Condition:   Stroke
Interventions:   Drug: Fluoxetine;   Drug: Placebo;   Radiation: fMRI
Sponsor:   University Hospital, Toulouse
Recruiting - verified May 2016

A Study to Evaluate the Efficacy and Safety of TF0023 Spray on Subjects With Ischemic Strokes

Condition:   Ischemic Stroke
Intervention:   Drug: TF0023
Sponsor:   Techfields Inc
Not yet recruiting - verified May 2016

Carotid Artery Stenting Without Protection

Condition:   Carotid Arteries
Interventions:   Device: CAS with CPD;   Other: CAS without CPD
Sponsor:   Acibadem University
Recruiting - verified May 2016

Assessment of the Effect of Vitamin C on Anemia in Patients With Continuous Ambulatory Peritoneal Dialysis

Condition:   Anemia
Interventions:   Drug: vitamin c;   Drug: placebo
Sponsor:   Shiraz University of Medical Sciences
Completed - verified May 2016

Links Between Depression, Anxiety, Coping and Quality of Life After a Stroke

Condition:   Cerebral Stroke
Intervention:   Other: survey
Sponsors:   Groupe Hospitalier Paris Saint Joseph;   University of Paris 5 - Rene Descartes;   Institut Universitaire Paris DESCARTES de Psychologie;   Laboratoire Psychopathologie et Processus de Santé
Recruiting - verified May 2016

Robot-assisted Gait Training for Patients With Stroke

Condition:   Cerebrovascular Accident
Interventions:   Procedure: Standard rehab;   Device: Robot-assisted gait rehabilitation
Sponsors:   China Medical University Hospital;   HIWIN Technologies Corporation
Not yet recruiting - verified May 2016

Study of Progression of Community Acquired Pneumonia in the Hospital

Conditions:   Pneumonia;   Sepsis;   Shock, Septic
Intervention:  
Sponsors:   Pneumonia Research Network on Genetic Resistance and Susceptibility for the Evolution of Severe Seps;   University of Leipzig;   Jena University Hospital;   Justus-Liebig-University Giessen;   University Medicine Greifswald;   Charite University, Berlin, Germany;   German Federal Ministry of Education and Research
Recruiting - verified May 2016

Text Messages and Blood Pressure Control

Condition:   Hypertension
Intervention:   Other: Bi-directional texting
Sponsor:   University of Iowa
Recruiting - verified May 2016

Prognostic and Diagnostic Value of Biomarkers and Cardiac Functional Parameters in Patients With Chronic Heart Failure

Condition:   Chronic Heart Failure
Intervention:   Other: Observational study
Sponsor:   Shanghai Jiao Tong University School of Medicine
Recruiting - verified May 2016

Motor Imagery Training in Persons With Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:   Other: Motor imagery training
Sponsor:   Dokuz Eylul University
Enrolling by invitation - verified May 2016

Feasibility of Perioperative Stellate Ganglion Blocks in Cardiac Surgery

Condition:   Atrial Fibrillation
Intervention:   Procedure: Stellate Ganglion Block
Sponsor:   Christopher Connors, MD
Enrolling by invitation - verified May 2016

STrategic Reperfusion in Elderly Patients Early After Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Drug: Tenecteplase;   Drug: Clopidogrel;   Procedure: Coronary angiography;   Procedure: Primary PCI
Sponsors:   Katholieke Universiteit Leuven;   Boehringer Ingelheim;   Life Sciences Research Partners;   Fund for Clinical Cardiovascular Research at LRD
Not yet recruiting - verified May 2016

Combination of Metformine/Inulin Versus Metformin on Prostate Benign Hyperplasia in Metabolic Syndrome

Condition:   Metabolic Syndrome
Interventions:   Drug: Metformin;   Dietary Supplement: Agave inulin;   Other: Placebo of agave inulin;   Other: Metformin placebo
Sponsor:   Centro Universitario de Ciencias de la Salud, Mexico
Completed - verified May 2016

Clopidogrel for Acute Ischaemia of Recent Onset

Condition:   Ischemic Cerebrovascular Accident
Interventions:   Drug: Clopidogrel;   Drug: Aspirin
Sponsor:   Ain Shams University
Not yet recruiting - verified May 2016

Anticoagulant Safety at Hospital Discharge

Condition:   Anticoagulants
Intervention:   Other: Anticoagulation Coordinated Care
Sponsors:   St. Joseph's Healthcare Hamilton;   Hamilton Academic Health Sciences Organization;   Institute for Safe Medication Practices Canada;   InfoClin;   Sykes Assistance Services Corporation
Not yet recruiting - verified May 2016

Xarelto on Prevention of Stroke and Non-central Nervous System Systemic Embolism in Patients With Non-valvular Atrial Fibrillation in China

Condition:   Stroke
Intervention:   Drug: Rivaroxaban (Xarelto, BAY 59-7939)
Sponsor:   Bayer
Recruiting - verified May 2016

Prospective Study Evaluating the Interest of Long-term Cardiac Recording in Cerebral Infarction

Condition:   Neuropathology
Intervention:   Device: Uses of SpiderFlash monitor
Sponsor:   Groupe Hospitalier Paris Saint Joseph
Recruiting - verified May 2016

Precutaneous High Risk Patent Foramen Ovale to Treat Migraine Headaches

Condition:   Patent Foramen Ovale
Intervention:   Procedure: the transcatheter closure of PFO
Sponsors:   First Affiliated Hospital Xi'an Jiaotong University;   Second Affiliated Hospital of Xi'an Jiaotong University;   Fourth Military Medical University;   Southwest Hospital, China
Not yet recruiting - verified February 2016

Optimizing Strategy of Coronary Revascularization in Patients With Multivessel Lesions Combined Heart Failure

Condition:   Heart Failure Due to Coronary Artery Disease
Interventions:   Procedure: Coronary Artery Bypass Grafting;   Procedure: Percutaneous Coronary Intervention;   Procedure: Hybrid Coronary Revascularization
Sponsor:   Shanghai Jiao Tong University School of Medicine
Recruiting - verified May 2016

Mirror Box Imaging Study

Condition:   Stroke
Intervention:   Other: Mirror Box therapy
Sponsors:   Southend University Hospital Foundation NHS Trust;   Anglia Ruskin University
Recruiting - verified April 2016

Mobile Service Robot for Task-Oriented Stroke Therapy: User Evaluations

Condition:   Stroke
Intervention:   Device: Mobile Service Robot
Sponsor:   University of Pennsylvania
Active, not recruiting - verified March 2016

CT COMPARE: CT COronary Angiography to Measure PlAque REduction

Condition:   Cardiovascular Disease
Interventions:   Drug: Rosuvastatin;   Drug: Atorvastatin
Sponsor:   National Institutes of Health Clinical Center (CC)
Recruiting - verified May 2016

Effect of Personalized Robotic Therapy

Condition:   Stroke
Interventions:   Device: Arm Light Exoskeleton Rehab Station (ALEx RS);   Device: Arm Light Exoskeleton Rehab Station (ALEx RS) - automatically personalized
Sponsors:   Wearable Robotics srl.;   University Hospital, Geneva;   Azienda Ospedaliero, Universitaria Pisana;   École polytechnique fédérale de Lausanne
Not yet recruiting - verified May 2016

Arm Motor Control on Bi and Uni ADLs

Conditions:   Stroke;   Peripheral Neuropathy;   Spinal Cord Injuries;   Cerebral Palsy
Intervention:   Device: Bilateral assessment robots (BiAS)
Sponsor:   University of Pennsylvania
Recruiting - verified April 2016

Assessment of Arterial Dynamic Elastance as a Function Variable of Arterial Load

Condition:   Hypovolemia
Interventions:   Device: arterial line;   Device: Cheetah®
Sponsor:   Universitair Ziekenhuis Brussel
Not yet recruiting - verified May 2016

Meta-analyses of Impotrant Food Sources of Sugars and Incident Cardiometabolic Diseases

Conditions:   Diabetes Mellitus, Type 2;   Metabolic Syndrome X;   Hypertension;   Cardiovascular Diseases;   Stroke
Intervention:   Other: Fructose-containing Sugars
Sponsors:   University of Toronto;   Canadian Institutes of Health Research (CIHR);   The Physicians' Services Incorporated Foundation;   Canadian Diabetes Association (CDA)
Active, not recruiting - verified May 2016

Brainstem Grey Matter and Cerebral Autoregulation in Migraine With Aura.

Condition:   Migraine With Aura
Interventions:   Other: Magnetic resonance imaging;   Other: Transcranial Doppler
Sponsor:   University Hospital, Toulouse
Not yet recruiting - verified May 2016

Perinatal Stroke: Understanding Brain Reorganization

Conditions:   Stroke;   Hemiparesis
Interventions:   Device: Magnetic Resonance Imaging;   Device: Transcranial Magnetic Stimulation;   Behavioral: General Movement Assessment
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Cerebral Palsy Alliance Research Foundation;   American Academy of Cerebral Palsy and Developmental Medicine
Recruiting - verified May 2016

Safety and Efficacy Study of a Protease Activated Receptor-4 Antagonist Being Tested to Reduce the Chances of Having Additional Strokes or "Mini Strokes"

Condition:   Thrombosis
Interventions:   Drug: BMS-986141;   Drug: Aspirin;   Other: Placebo
Sponsor:   Bristol-Myers Squibb
Recruiting - verified January 2016

Remote Ischaemic Conditioning After Stroke Trial (ReCAST-2)

Condition:   Stroke
Interventions:   Procedure: Remote ischaemic conditioning;   Procedure: Sham
Sponsor:   University of Nottingham
Not yet recruiting - verified May 2016

The Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis

Condition:   Aortic Stenosis
Interventions:   Procedure: Surgical aortic valve replacement (SAVR);   Device: Transcatheter Aortic Valve Replacement (TAVR)
Sponsor:   Edwards Lifesciences
Recruiting - verified May 2016

Combination of Motor Imagery Exercises and Brain Stimulation TMS Type PAS in Patients After Hemiplegic Stroke

Condition:   Stroke
Interventions:   Procedure: Paired Associative Stimulation;   Procedure: Paired Associative Stimulation + Motor Imagery exercises;   Procedure: Placebo Paired Associative Stimulation + Motor Imagery exercises
Sponsor:   University Hospital, Toulouse
Recruiting - verified May 2016

A Study of the ReCor Medical Paradise System in Clinical Hypertension

Conditions:   Hypertension;   Vascular Diseases
Interventions:   Device: The Paradise® Renal Denervation Ultrasound System;   Device: Sham Procedure
Sponsor:   ReCor Medical, Inc.
Recruiting - verified March 2016

Length of Stay in NVAF Patients Hospitalized and Initiated With Dabigatran or Warfarin in Japan

Condition:   Atrial Fibrillation
Interventions:   Drug: Dabigatran;   Drug: Wafrarin
Sponsor:   Boehringer Ingelheim
Not yet recruiting - verified May 2016

The Effects of tDCS Combined With Balance Training on Lower Limbs Spasticity in Chronic Stroke Patients

Condition:   Ischemic Stroke
Interventions:   Device: Transcranial direct current stimulation (tDCS);   Device: Sham tDCS
Sponsor:   Shahid Beheshti University of Medical Sciences
Active, not recruiting - verified May 2016

Performing a Low-dose, Whole-body Angiography as the First Element of an Imaging Assessment Following Stroke / TIA

Conditions:   Stroke;   Ischemic Attack, Transient
Interventions:   Other: Routine Imaging Assessment;   Device: LDWBA first (CT scan)
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Not yet recruiting - verified May 2016

Patient Convenience Study (RE-SONANCE)

Conditions:   Atrial Fibrillation;   Stroke
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified May 2016

Predictors for Postoperative Delirium After Cardiac Surgery With Extracorporeal Circulation in Adults: a One-year, Single Center, Observational Cohort Study

Condition:   Postoperative Delirium
Intervention:   Other: no intervention
Sponsor:   University Hospital, Basel, Switzerland
Completed - verified May 2016

Patient Convenience Study

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified May 2016

Nesiritide in Uncontrolled Hypertension

Condition:   Hypertension
Interventions:   Drug: Nesiritide;   Drug: Placebo
Sponsors:   Oslo University Hospital;   University of Oslo;   University Hospital, Akershus
Recruiting - verified December 2015

Clinical Benefits of the Closed Loop Stimulation in Sinus Node Disease

Condition:   Sinus Node Disease
Interventions:   Device: DDD+CLS;   Device: DDD(R)
Sponsor:   Biotronik SE & Co. KG
Recruiting - verified May 2016

Evaluation of a Tele-Rehabilitation Service Program

Conditions:   Stroke;   Paresis
Intervention:   Device: Tele-motion rehabilitation system
Sponsors:   Mayo Clinic;   The Gertner Institute;   ReAbility Online
Recruiting - verified May 2016

Tumor Hypoxia With HX4 PET in Several Diseases

Conditions:   Prostatic Neoplasms;   Esophageal Neoplasms;   Neoplasm Metastases, Brain;   Rectal Neoplasms;   Brain Neoplasm, Primary
Intervention:   Drug: Injection with the hypoxia tracer [18F]HX4,
Sponsor:   Maastricht Radiation Oncology
Recruiting - verified May 2016

Customized Cortical Stimulation Therapy in the Rehabilitation of Stroke Patients

Condition:   Stroke
Interventions:   Device: Single-pulse Transcranial Magnetic Stimulation (TMS);   Device: Paired-pulse Transcranial Magnetic Stimulation (ppTMS);   Device: Low-frequency Repetitive Transcranial Magnetic Stimulation (rTMS);   Device: Sham Motor Cortex Stimulation
Sponsors:   Emory University;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified May 2016

Validation of a Purine Biosensor in Detecting Acute Cerebral Ischaemia: Carotid Endarterectomy Model in SMARTChip

Condition:   Stroke
Intervention:  
Sponsors:   University Hospitals Coventry and Warwickshire NHS Trust;   University Hospitals of North Midlands NHS Trust
Recruiting - verified May 2016

Global Study Comparing a rivAroxaban-based Antithrombotic Strategy to an antipLatelet-based Strategy After Transcatheter aortIc vaLve rEplacement to Optimize Clinical Outcomes

Condition:   Transcatheter Aortic Valve Replacement
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Acetylsalicylic acid;   Drug: Clopidogrel
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting - verified May 2016

Epidemiological Study on the Safety of Aspirin in The Health Improvement Network (THIN)

Conditions:   Secondary Prevention;   Stroke;   Ischemic Heart Disease;   Coronary Heart Disease
Interventions:   Drug: Acetylsalicylic Acid (Asprin, BAYE4465);   Drug: Clopidogrel, Oral Anticoagulants, NSAIDs and SSRIs
Sponsor:   Bayer
Recruiting - verified May 2016

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified May 2016

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified May 2016

HT-3951 vs. Placebo in Stroke Rehabilitation

Condition:   Ischemic Stroke
Interventions:   Drug: HT-3951;   Drug: Placebo
Sponsor:   Dart NeuroScience, LLC
Recruiting - verified February 2016

Stroke and Traumatic Acute Brain Injury Line Indicator System for Emergent Recognition (STABILISER-I)

Conditions:   Ischemic Stroke;   Hemorrhagic Stroke;   Traumatic Brain Injury
Intervention:   Device: Lateral Flow Device
Sponsor:   University of Kentucky
Recruiting - verified May 2016

Clinical Relevance of Microbleeds In Stroke

Conditions:   Stroke;   Atrial Fibrillation (AF);   Intracerebral Haemorrhage (ICH)
Intervention:  
Sponsor:   University College, London
Active, not recruiting - verified July 2015

Platelet Reactivity in Acute Non-disabling Cerebrovascular Events

Conditions:   Stroke;   Ischemic Attack, Transient
Interventions:   Drug: Ticagrelor and Acetylsalicylic acid;   Drug: Clopidogrel and Acetylsalicylic acid
Sponsors:   Ministry of Science and Technology of the People´s Republic of China;   Beijing Municipal Science & Technology Commission
Recruiting - verified May 2016

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Recruiting - verified May 2016

Forced Aerobic Exercise for Stroke Rehabilitation

Condition:   Stroke
Interventions:   Behavioral: Forced Exercise & Upper Extremity Repetitive Task Practice;   Behavioral: Voluntary Exercise & Upper Extremity Repetitive Task Practice;   Behavioral: Stroke Education & Upper Extremity Repetitive Task Practice
Sponsors:   The Cleveland Clinic;   American Heart Association
Recruiting - verified May 2016

PeRiodontal Treatment to Eliminate Minority InEquality and Rural Disparities in Stroke

Conditions:   Periodontal Disease;   Stroke;   TIA
Interventions:   Procedure: Intensive dental treatment;   Procedure: Standard dental treatment;   Drug: Arestin
Sponsors:   University of South Carolina;   University of North Carolina, Chapel Hill
Recruiting - verified May 2016

App-delivered Therapy for Arabic Readers With Hemianopic Alexia

Condition:   Stroke
Intervention:   Behavioral: Reading Training
Sponsor:   University College London Hospitals
Not yet recruiting - verified May 2016

Assessment of the GORE® EXCLUDER® Conformable AAA Endoprosthesis in the Treatment of Abdominal Aortic Aneurysms

Condition:   Aortic Aneurysm, Abdominal
Intervention:   Device: GORE® EXCLUDER® Conformable AAA Endoprosthesis
Sponsor:   W.L.Gore & Associates
Not yet recruiting - verified May 2016

Acupuncture for Ischemic Post-stroke Depression

Condition:   Post-stroke Depression
Interventions:   Device: acupuncture;   Drug: placebo;   Device: sham-acupoint acupuncture;   Drug: Fluoxetine
Sponsors:   Menghan Li;   State Administration of Traditional Chinese Medicine of the People's Republic of China
Recruiting - verified May 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsor:   Bayer
Recruiting - verified May 2016

Exploring the Effectiveness of Sensor-based Balance Training on Patient Outcome Measures

Conditions:   Diabetes;   Cancer;   Multiple Sclerosis;   Arthritis;   Parkinson's Disease;   Cognitive Disorders;   Brain Injury;   Stroke
Interventions:   Procedure: Exergame;   Procedure: Home based balance training
Sponsor:   University of Arizona
Recruiting - verified May 2016

Pharyngeal Electrical Stimulation for the Treatment of Post-extubation Dysphagia in Acute Stroke

Conditions:   Stroke;   Dysphagia
Interventions:   Device: Phagenyx-Catheter, Phagenesis Limited, UK.;   Device: Sham stimulation
Sponsor:   University Hospital Muenster
Recruiting - verified May 2016

Unilateral vs. Bilateral Approaches to Hybrid Stroke Rehabilitation

Condition:   Stroke
Interventions:   Procedure: Unilateral Hybrid Intervention;   Procedure: Bilateral Hybrid Intervention;   Procedure: Robot-Assisted Training
Sponsor:   Chang Gung Memorial Hospital
Enrolling by invitation - verified April 2015

In Vivo Imaging of Therapeutic Electric Current Flow

Conditions:   Parkinson Disease;   Epilepsy;   Alzheimer's Disease;   Stroke;   Autism;   Depression;   Schizophrenia
Interventions:   Device: Transcranial direct current stimulation;   Procedure: MRI
Sponsors:   University of Florida;   Arizona State University;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016

Clear-Road Trial, Investigating the Efficacy of the RoadSaver Stent

Condition:   Peripheral Arterial Disease
Intervention:   Device: RoadSaver stent
Sponsor:   Flanders Medical Research Program
Active, not recruiting - verified February 2016

Intraoperative Fluid Therapy for Deceased Donor Renal Transplantation

Condition:   Kidney Failure
Intervention:   Device: Esophageal Doppler Monitor
Sponsor:   University Health Network, Toronto
Active, not recruiting - verified October 2015

Cardiac Output Monitoring in Burn Patients

Condition:   Burns
Intervention:   Device: NICOM (non-invasive cardiac output monitor)
Sponsor:   Emory University
Recruiting - verified May 2016

Rate Control Therapy Evaluation in Permanent Atrial Fibrillation (RATE-AF)

Condition:   Permanent Atrial Fibrillation
Interventions:   Drug: Bisoprolol;   Drug: Digoxin
Sponsor:   University of Birmingham
Not yet recruiting - verified May 2016

Influence on Plasticity of Brain Temperature

Condition:   Healthly Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016

Do Arterial Catheters Reduce the Risk of Major Perioperative Complications

Condition:   Postoperative Complications
Interventions:   Procedure: non-cardiac surgery;   Other: arterial catheter
Sponsor:   The Cleveland Clinic
Recruiting - verified May 2016

Uninterrupted Dabigatran Etexilate in Comparison to Uninterrupted Warfarin in Pulmonary Vein Ablation (RE-CIRCUIT)

Condition:   Atrial Fibrillation
Interventions:   Drug: Warfarin;   Drug: Dabigatran Etexilate 150mg
Sponsor:   Boehringer Ingelheim
Recruiting - verified May 2016

Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease

Condition:   Coronary Artery Disease
Interventions:   Procedure: Computed tomography angiography (cardiac CT);   Procedure: Invasive coronary angiography (ICA)
Sponsor:   Charite University, Berlin, Germany
Recruiting - verified May 2016

PCORI-1310-06998 Trial of a Decision Support Intervention for Patients and Caregivers Offered Destination Therapy Heart Assist Device

Conditions:   Heart Failure;   Heart-assist Devices
Intervention:   Behavioral: DT LVAD Decision Support Intervention
Sponsors:   University of Colorado, Denver;   Patient-Centered Outcomes Research Institute
Recruiting - verified May 2016

Intraoperative Analysis of Reward and Impulsivity in the Basal Ganglia

Condition:   Parkinson's Disease
Intervention:  
Sponsors:   Duke University;   National Institute of Neurological Disorders and Stroke (NINDS)
Enrolling by invitation - verified November 2015

Human Umbilical Cord Mesenchymal Stem Cell in Cerebral Hemorrhage Sequela

Condition:   Cerebral Hemorrhage
Intervention:   Biological: Human umbilical cord mesenchymal stem cells
Sponsors:   Shenzhen Hornetcorn Bio-technology Company, LTD;   The Fifth Affiliated Hospital of Guangzhou Medical University
Active, not recruiting - verified July 2015

Bilateral Priming for Upper Extremity Hemiparesis in Older Adults

Condition:   Stroke, Upper Extremity Hemiparesis
Intervention:   Behavioral: priming and task specific training
Sponsor:   Rush University Medical Center
Completed - verified May 2016

Biomarker Signature of Stroke Aetiology Study: The BIOSIGNAL-Study

Condition:   Stroke, Acute
Intervention:  
Sponsors:   University of Zurich;   Swiss National Science Foundation
Recruiting - verified May 2016

Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability

Conditions:   Chronic Troublesome Sialorrhea;   Cerebral Palsy;   Stroke;   Traumatic Brain Injury;   Intellectual Disability
Interventions:   Drug: IncobotulinumtoxinA;   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Recruiting - verified May 2016

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified May 2016

Decompressive Hemicraniectomy in Intracerebral Hemorrhage

Condition:   Cerebral Hemorrhage
Interventions:   Procedure: Decompressive craniectomy (DC) and best medical treatment;   Procedure: Best medical treatment
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified May 2016

Drug Persistence/Adherence in Patients Treated With Dabigatran or VKA for Stroke Prevention in Non Valvular Atrial Fibrillation (SPAF)

Condition:   Atrial Fibrillation
Interventions:   Drug: Dabigatran etexilate;   Drug: Phenprocoumon
Sponsor:   Boehringer Ingelheim
Recruiting - verified May 2016

Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

Conditions:   Stroke;   Secondary Prevention
Interventions:   Drug: optional ASA as comedication;   Drug: placebo to ASA;   Drug: placebo to optional ASA as comedication;   Drug: placebo to dabigatran etexilate;   Drug: ASA 100 mg;   Drug: dabigatran etexilate
Sponsor:   Boehringer Ingelheim
Recruiting - verified May 2016

The CREST-2 Registry

Condition:   Carotid Artery Diseases
Intervention:   Device: Carotid Artery Stent
Sponsors:   University of Maryland;   National Institute of Neurological Disorders and Stroke (NINDS);   Centers for Medicare and Medicaid Services;   Mayo Clinic;   Society for Vascular Surgery;   American College of Cardiology
Recruiting - verified May 2016

Superselective Administration of VErapamil During Recanalization in Acute Ischemic Stroke

Condition:   Ischemic Stroke
Intervention:   Drug: Verapamil
Sponsor:   University of Kentucky
Active, not recruiting - verified May 2016

Left-Atrium-Appendage Occluder Register - GErmany

Conditions:   Atrial Fibrillation;   Stroke
Intervention:  
Sponsor:   Stiftung Institut fuer Herzinfarktforschung
Active, not recruiting - verified May 2016

Feasibility Controlled Trial of Tibial Nerve Stimulation for Stroke Related Urinary Incontinence

Conditions:   Stroke;   Urinary Incontinence
Interventions:   Device: NeuroTrac continence stimulators;   Device: NeuroTrac continence stimulators
Sponsors:   Glasgow Caledonian University;   The Stroke Association, United Kingdom;   University of Central Lancashire;   Nursing, Midwifery & Allied Health Professions Research Unit;   NHS Greater Glasgow and Clyde;   NHS Lanarkshire
Completed - verified February 2016

Embolectomy in Acute SYlvian Thrombosis in Refractory or Ineligible Patients to ALteplase

Condition:   Stroke, Acute
Interventions:   Other: Hospitalization in specialized neuro-vascular unit;   Drug: Alteplase if patient is eligible;   Other: Supportive care;   Procedure: Endovascular treatment
Sponsor:   Fondation Ophtalmologique Adolphe de Rothschild
Recruiting - verified May 2016

AOP2014 in Patients With Polycythemia Vera Who Previously Participated in the PROUD-PV Study.

Condition:   Polycythemia Vera
Intervention:   Drug: Pegylated-Proline-interferon alpha-2b
Sponsors:   AOP Orphan Pharmaceuticals AG;   PharmaEssentia (Co-Sponsor for USA)
Recruiting - verified May 2016

The Effects of tDCS Combined With Balance Training on Postural Control in Chronic Stroke Patients

Condition:   Ischemic Stroke
Interventions:   Device: Transcranial direct current stimulation (tDCS);   Device: Sham
Sponsor:   Shahid Beheshti University of Medical Sciences
Recruiting - verified May 2016

Healthy Lifestyles After Stroke

Conditions:   Stroke;   Apoplexy;   Cerebral Stroke;   Cerebrovascular Accident;   Cerebrovascular Accident, Acute;   Cerebrovascular Apoplexy;   Cerebrovascular Stroke;   CVA;   Stroke, Acute;   Vascular Accident, Brain
Intervention:   Behavioral: Healthy Lifestyle Training Program
Sponsors:   University of British Columbia;   Canadian Institutes of Health Research (CIHR);   Heart and Stroke Foundation of Canada
Recruiting - verified May 2016

CT or MRI in Work up for i.v. Thrombolysis: a Single-centre Study

Condition:   Acute Stroke
Interventions:   Other: Computerized Tomography;   Other: Magnetic Resonance Imaging
Sponsors:   Bispebjerg Hospital;   TRYG Foundation
Completed - verified May 2016

Prospective Study on Embolization of Intracranial Aneurysms With Pipeline™ Embolization Device

Condition:   Intracranial Aneurysm
Intervention:   Device: Pipeline™ Embolization Device/ Pipeline™Flex Embolization Device
Sponsor:   Medtronic Neurovascular Clinical Affairs
Active, not recruiting - verified May 2016

Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage (The PATCH Study)

Conditions:   Wounds and Injuries;   Acute Coagulopathy
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsors:   National Trauma Research Institute;   National Health and Medical Research Council, Australia
Recruiting - verified May 2016

The Role of Gut Microbiota in Hypertension

Condition:   Hypertension
Intervention:   Other: Stool Sample and Blood Sample
Sponsor:   University of Florida
Recruiting - verified May 2016

Optimal Anticoagulation for Higher Risk Patients Post-Catheter Ablation for Atrial Fibrillation Trial

Conditions:   Atrial Fibrillation;   Stroke
Interventions:   Drug: Rivaroxaban;   Drug: Acetylsalicylic acid
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research (CIHR);   Bayer;   Biotronik SE & Co. KG
Recruiting - verified May 2016

Sedation vs. Intubation for Endovascular Stroke TreAtment

Condition:   Acute Ischemic Stroke
Intervention:   Procedure: Endovascular recanalisation
Sponsor:   University Hospital Heidelberg
Completed - verified May 2016

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Condition:   Carotid Stenosis
Interventions:   Procedure: Carotid endarterectomy;   Device: Carotid stenting
Sponsors:   Thomas G. Brott, M.D.;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016

Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions

Conditions:   Chronic Troublesome Sialorrhea;   Parkinson's Disease;   Post-stroke;   Traumatic Brain Injury
Interventions:   Drug: IncobotulinumtoxinA (100 Units);   Drug: IncobotulinumtoxinA (75 Units);   Drug: Placebo
Sponsor:   Merz Pharmaceuticals GmbH
Active, not recruiting - verified May 2016

Study Of The Blood Thinner, Apixaban, For Patients Who Have An Abnormal Heart Rhythm (Atrial Fibrillation) And Expected To Have Treatment To Put Them Back Into A Normal Heart Rhythm (Cardioversion)

Condition:   Atrial Fibrillation
Interventions:   Drug: Apixaban;   Drug: Parenteral heparin and/or oral Vitamin K antagonist
Sponsors:   Pfizer;   Bristol-Myers Squibb
Recruiting - verified May 2016

Memantine for Enhanced Stroke Recovery

Conditions:   Ischemic Stroke;   Upper Extremity Weakness
Interventions:   Drug: Memantine XR;   Drug: Placebo (for memantine)
Sponsor:   University of Utah
Recruiting - verified May 2016

Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency

Conditions:   Metabolic Disease;   Seizures
Interventions:   Drug: SGS-742;   Drug: Placebo
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016

Multicenter Comparison of Early and Late Vascular Responses to Everolimus-eluting Cobalt-CHromium Stent and Platelet AggregatioN studIeS for TreatMent of Acute Myocardial InfarctionTreatment of ST-elevation Acute Myocardial Infarction

Condition:   Coronary Artery Disease
Intervention:   Device: cobalt-chromium everolimus-eluting stent (CoCr-EES)
Sponsor:   Iwate Medical University
Active, not recruiting - verified May 2016

Synergistic Enteral Regimen for Treatment of the Gangliosidoses

Conditions:   GM1 Gangliosidoses;   GM2 Gangliosidoses;   Tay-Sachs Disease;   Sandhoff Disease
Interventions:   Drug: miglustat;   Other: Ketogenic Diet
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2016

The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified May 2016

Clinical Outcomes Following Parafascicular Surgical Evacuation of Intracerebral Hemorrhage: A Pilot Study

Condition:   Intracerebral Hemorrhage
Intervention:  
Sponsor:   OSF Healthcare System
Completed - verified May 2016

Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Hyperlipidemia or Mixed Dyslipidemia at Risk of Cardiovascular Events

Condition:   Hyperlipidemia
Interventions:   Drug: Bococizumab (PF-04950615; RN316);   Other: Placebo
Sponsor:   Pfizer
Recruiting - verified May 2016

Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation

Conditions:   Amyotrophic Lateral Sclerosis;   Frontotemporal Lobar Degeneration
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute on Aging (NIA)
Recruiting - verified May 2016

Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Placebo;   Drug: Linagliptin
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified May 2016

A Gray Zone Approach to Stroke Volume Variation Derived From NICOM

Conditions:   Neurological Diseases or Conditions;   Fluid Responsiveness;   Non Invasive Cardiac Output Monitoring;   Gray Zone
Intervention:   Other: 500ml fluid loading
Sponsor:   Samsung Medical Center
Withdrawn - verified May 2016

Community Level Interventions for Pre-eclampsia

Conditions:   Pre-eclampsia;   Hypertension, Pregnancy Induced
Interventions:   Behavioral: Community Engagement;   Device: PIERS on the Move mHealth decision aid;   Drug: Magnesium Sulfate;   Drug: Methyldopa
Sponsors:   University of British Columbia;   Bill and Melinda Gates Foundation;   Olabisi Onabanjo University;   Centro de Investigacao em Saude de Manhica;   Aga Khan University;   Jawaharlal Nehru Medical College
Recruiting - verified May 2016

Thinking and Memory Problems in People With HIV

Conditions:   Acquired Immunodeficiency;   Neurocognitive Disorders
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016

Leukine (Sargramostim) for Parkinson's Disease

Condition:   Parkinson's Disease
Interventions:   Procedure: blood draw;   Procedure: physical exam and UPDRS part III assessment;   Procedure: blood draw;   Procedure: physical exam and UPDRS part III assessment;   Procedure: blood draw;   Procedure: physical exam and UPDRS part III assessment;   Procedure: MEG;   Drug: sargramostim;   Drug: placebo;   Procedure: blood draw;   Procedure: physical exam and UPDRS part III assessment;   Procedure: blood draw;   Procedure: physical exam and UPDRS part III assessment;   Procedure: blood draw;   Procedure: physical exam and UPDRS part III assessment;   Procedure: blood draw;   Procedure: physical exam and UPDRS part III assessment;   Procedure: MEG;   Procedure: blood draw;   Behavioral: physical exam and UPDRS part III assessment;   Procedure: Motion Analysis;   Procedure: Motion Analysis;   Procedure: Motion Analysis
Sponsors:   Howard Gendelman, MD;   Sanofi;   National Institute of Neurological Disorders and Stroke (NINDS);   UNeMed;   Nebraska Neuroscience Alliance
Completed - verified May 2016

Ischaemic Stroke and Sleep Apnea in Northern Part of Finland

Conditions:   Sleep Apnoea;   Cerebral Palsy
Intervention:   Device: Nasal CPAP
Sponsor:   University of Oulu
Completed - verified May 2016

GLP-1 and Hypoglycemia

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Glucagon-Like Peptide- 1 (GLP-1) infusion;   Other: Placebo Comparator: Saline Infusion
Sponsor:   University of Maryland
Recruiting - verified May 2016

A Randomized, Non-inferiority Clinical Trial of CVA Telerehabilitation Treatments - TelePhysioTaiChi

Condition:   Stroke
Intervention:   Behavioral: Tai Chi based exercise program
Sponsors:   Université de Sherbrooke;   Université de Montréal;   University of Toronto
Recruiting - verified May 2016

LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease

Condition:   Parkinson's Disease
Intervention:  
Sponsors:   University of Alabama at Birmingham;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016

Brain Integrity in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation

Condition:   Hodgkin Lymphoma
Interventions:   Other: Neurocognitive Evaluation;   Other: Quantitative Brain Imaging;   Other: Neurologic Evaluation;   Other: Health Questionnaire;   Other: Vascular Testing;   Other: Cardiopulmonary Exercise Testing;   Other: Echocardiography;   Other: Pulmonary Function Testing;   Procedure: Serum Biomarkers;   Other: Ophthalmology Examination;   Other: Sleep Assessment
Sponsors:   St. Jude Children's Research Hospital;   National Cancer Institute (NCI)
Recruiting - verified May 2016

Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation in Latinamerica and EMEA Region

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsor:   Bayer
Active, not recruiting - verified May 2016

SPARK: Safety Study of Pradaxa in Atrial Fibrillation Patients by Regulatory Requirement of Korea

Condition:   Atrial Fibrillation
Intervention:   Drug: Pradaxa (Dabigatran etexilate mesilate)
Sponsor:   Boehringer Ingelheim
Recruiting - verified May 2016

Enoxaparin Versus Aspirin in Patients With Cancer and Stroke

Condition:   Cancer Patients First-ever Acute Ischemic Stroke
Interventions:   Drug: Enoxaparin;   Drug: Aspirin
Sponsors:   Memorial Sloan Kettering Cancer Center;   New York Presbyterian Hospital;   Weill Medical College of Cornell University
Recruiting - verified May 2016

Xarelto for Prevention of Stroke in Patients With Atrial Fibrillation in Asia

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsor:   Bayer
Completed - verified May 2016

A Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease

Condition:   Peripheral Artery Disease
Interventions:   Drug: Ticagrelor;   Drug: Clopidogrel
Sponsor:   AstraZeneca
Active, not recruiting - verified May 2016

A Study to Assess Cardiovascular Outcomes Following Treatment With Omarigliptin (MK-3102) in Participants With Type 2 Diabetes Mellitus (MK-3102-018)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Omarigliptin;   Drug: Placebo
Sponsor:   Merck Sharp & Dohme Corp.
Terminated - verified May 2016

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified May 2016

Prospective Characterization of the Heart, Aorta and Blood Pressure in Turner Syndrome. Association With Aortic Dissection.

Conditions:   Turner Syndrome;   Aortic Aneurysm;   Ischemic Heart Disease;   Hypertension;   Congenital Heart Defect
Intervention:  
Sponsor:   University of Aarhus
Active, not recruiting - verified June 2015

Acute Versus Subacute Angioplasty in Patients With NON-ST-Elevation Myocardial Infarction

Condition:   Myocardial Infarction
Intervention:   Procedure: Group I: Primary PCI
Sponsor:   Aarhus University Hospital Skejby
Terminated - verified May 2016

AAV2-GDNF for Advanced Parkinson s Disease

Condition:   Parkinson's Disease
Intervention:   Genetic: Convection enhanced delivery/AAV2-GDNF
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016

BOTOX® Treatment in Pediatric Upper Limb Spasticity

Conditions:   Pediatrics;   Muscle Spasticity;   Cerebral Palsy;   Stroke
Interventions:   Biological: botulinum toxin Type A;   Biological: botulinum toxin Type A;   Drug: Normal Saline (Placebo)
Sponsor:   Allergan
Recruiting - verified May 2016

BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity

Conditions:   Pediatrics;   Muscle Spasticity;   Cerebral Palsy;   Stroke
Intervention:   Biological: botulinum toxin Type A
Sponsor:   Allergan
Recruiting - verified May 2016

A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Brilinta

Condition:   Acute Coronary Syndromes
Intervention:  
Sponsor:   AstraZeneca
Active, not recruiting - verified May 2016

Cardiovascular Inflammation Reduction Trial

Condition:   Cardiovascular Disease
Interventions:   Drug: Methotrexate;   Drug: Placebo
Sponsors:   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified May 2016

Xarelto [SPAF] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban(Xarelto, BAY59-7939)
Sponsor:   Bayer
Active, not recruiting - verified May 2016

Xarelto [SPAF-QOL] Post-marketing Surveillance in Japan

Condition:   Brain Ischemia
Intervention:   Drug: Rivaroxaban (Xarelto_ BAY59-7939)
Sponsor:   Bayer
Recruiting - verified May 2016

Long Term Split Belt Treadmill Training for Stroke Recovery

Conditions:   Stroke;   Hemiparesis
Intervention:   Behavioral: Split belt treadmill
Sponsors:   Hugo W. Moser Research Institute at Kennedy Krieger, Inc.;   National Institutes of Health (NIH);   National Institute on Aging (NIA);   University of Maryland;   VA Office of Research and Development
Active, not recruiting - verified May 2016

Carotid Structure and Function in MPS Syndromes: A Multicenter Study of the Lysosomal Disease Network

Conditions:   MPS I;   MPS II;   MPS VI;   Mucopolysaccharidoses
Intervention:  
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Active, not recruiting - verified May 2016

Structurally Reorganizing Motor Cortex in Stroke Patients Through Hebbian-type Stimulation

Condition:   Stroke
Interventions:   Device: Repetitive Transcranial Magnetic Stimulation (rTMS);   Device: Sham stimulation
Sponsors:   Cathrin Buetefisch;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified May 2016

Role of Ipsilateral Motor Cortex in Executing Movements With Increasing Demand on Precision

Condition:   Stroke
Intervention:  
Sponsors:   Cathrin Buetefisch;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified May 2016

Neurovascular Non Contrast-Enhanced MR Angiography at 3T

Condition:   Neurovascular Diseases
Intervention:  
Sponsor:   Rennes University Hospital
Recruiting - verified May 2016

Stroke Study: Operative Strategies to Reduce Cerebral Embolic Events During Coronary Artery Bypass Surgery

Condition:   Stroke
Interventions:   Procedure: No aortic clamping;   Procedure: partial occluding clamp;   Procedure: single cross clamp;   Procedure: cross clamp and partial occluding clamp
Sponsors:   Emory University;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified May 2016

Fluorescence-guided Surgery for Low- and High-grade Gliomas

Condition:   Glioma
Interventions:   Drug: 5-Aminolevulinic acid (ALA);   Drug: Placebo - ascorbic acid
Sponsor:   St. Joseph's Hospital and Medical Center, Phoenix
Recruiting - verified May 2016

Post-Marketing Surveillance of Prazaxa® on the Long-term Use in Patients With Nonvalvular Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Drug: Prazaxa
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified May 2016

Double Push Acoustic Radiation Force (DP ARF) Ultrasound for Monitoring Degeneration in Duchenne Muscular Dystrophy

Condition:   Muscular Dystrophy, Duchenne
Intervention:  
Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016

Role of Cerebral Oximetry In Reducing Delirium After Complex Cardiac Surgery

Condition:   Cardiac Disease
Interventions:   Device: Cerebral oximetry monitor (The INVOS® Cerebral/Somatic Oximeter);   Other: An alarm threshold at 75% of the baseline rSO2 value
Sponsor:   University Health Network, Toronto
Active, not recruiting - verified May 2016

International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Coronary Artery Disease;   Heart Diseases;   Myocardial Ischemia
Interventions:   Procedure: cardiac catheterization;   Procedure: coronary artery bypass graft surgery;   Procedure: percutaneous coronary intervention;   Behavioral: Lifestyle;   Drug: Medication
Sponsors:   New York University School of Medicine;   New York University;   Stanford University;   National Heart, Lung, and Blood Institute (NHLBI);   Albany Stratton VA Medical Center;   Cedars-Sinai Medical Center;   Columbia University;   Duke University;   East Carolina University;   Emory University;   Harvard University;   Massachusetts General Hospital;   Montreal Heart Institute;   University of British Columbia;   University of Missouri, Kansas City;   Vanderbilt University
Recruiting - verified May 2016

GLORIA-AF Registry Program - Second and Third Phases

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified May 2016

A Open-Label Study Of CP-690,550 As Long-Term Therapy (48 Weeks) In Subjects With Crohn's Disease

Condition:   Crohn's Disease
Interventions:   Drug: CP-690,550;   Drug: CP-690,550
Sponsor:   Pfizer
Recruiting - verified May 2016

Educational Interventions for Chronic Obstructive Pulmonary Disease (COPD) Self-management in Ethno-cultural Communities

Condition:   Chronic Obstructive Pulmonary Disease (COPD)
Interventions:   Behavioral: Group one;   Behavioral: Group two;   Behavioral: Group three;   Behavioral: Group four
Sponsors:   University of British Columbia;   Vancouver Coastal Health;   Main Line Health;   Provincial Health Services Authority;   Vancouver Foundation;   Heart and Stroke Foundation of Canada;   Canadian Institutes of Health Research (CIHR)
Completed - verified May 2016

Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device (LVAD) and Medical Management

Condition:   Heart Failure
Interventions:   Device: HM II (HeartMate II LVAD);   Drug: OMM (Optimal Medical Management)
Sponsor:   Thoratec Corporation
Active, not recruiting - verified May 2016

The Dystonia Coalition Natural History and Biospecimen Repository for Isolated Dystonias

Condition:   Dystonia
Intervention:  
Sponsors:   Hyder A. Jinnah, MD, PhD;   National Institute of Neurological Disorders and Stroke (NINDS);   Office of Rare Diseases (ORD);   Allergan;   Dystonia Study Group
Recruiting - verified May 2016

Early Thienopyridine Treatment to Improve Primary Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction

Conditions:   Myocardial Infarction;   STEMI
Interventions:   Drug: prasugrel;   Drug: Clopidogrel
Sponsors:   Stiftung Institut fuer Herzinfarktforschung;   Daiichi Sankyo Inc.
Completed - verified May 2016

Surgery as a Treatment for Medically Intractable Epilepsy

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Partial Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016

Treat Stroke to Target

Conditions:   Ischemic Stroke;   Transient Ischemic Attack;   Atherosclerotic Stenosis
Interventions:   Procedure: Target : 100 mg/dL (+/-10 mg/dL);   Procedure: 70 mg/dL
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Pfizer;   AstraZeneca;   Merck Sharp & Dohme Corp.
Recruiting - verified May 2016

CLOTBUST Hands-Free: A Phase I/II Pilot Safety Trial

Condition:   Stroke
Interventions:   Device: 2-MHz transcranial Doppler ultrasound;   Device: 2-MHz transcranial Doppler ultrasound insonation
Sponsors:   The University of Texas Health Science Center, Houston;   University of Alabama at Birmingham
Completed - verified May 2016

Living Well With Stroke

Conditions:   Cerebrovascular Stroke;   Depression
Interventions:   Behavioral: Brief pleasurable events/behavioral therapy;   Other: Standard care
Sponsors:   University of Washington;   National Institute of Nursing Research (NINR)
Completed - verified May 2016

Study of Shunt Flow Sensor Accuracy in Extra-ventricular Drains.

Conditions:   Hydrocephalus;   Nervous System Diseases;   Infant, Newborn Diseases
Intervention:  
Sponsors:   Transonic Systems Inc.;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified May 2016

Top-Down Attentional Control of Visual-Processing

Conditions:   Focal Brain Lesion;   Focal Lesions;   fMRI
Intervention:  
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting - verified May 2016

Strict or Liberal Insulin Protocol Following Coronary Artery Bypass Graft (CABG) Surgery

Conditions:   Blood Glucose;   Coronary Artery Bypass;   Insulin;   Coronary Disease
Intervention:   Other: LIBERAL
Sponsor:   Inova Health Care Services
Active, not recruiting - verified May 2016

Clinical and Economic Implications of Genetic Testing for Warfarin Management

Condition:   Blood Coagulation Disorders
Intervention:   Drug: Warfarin
Sponsors:   University of Chicago;   Agency for Healthcare Research and Quality (AHRQ)
Active, not recruiting - verified May 2016

Bilateral Versus Unilateral Task Retraining Using the SaeboFlex Orthosis

Condition:   Muscle Spasticity
Intervention:   Other: Task Training
Sponsor:   University of Missouri-Columbia
Terminated - verified May 2016

Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer

Conditions:   Pain/Cancer;   Pain, Intractable
Interventions:   Drug: (Resiniferatoxin)(RTX);   Drug: Intrathecal Resiniferatoxin
Sponsors:   National Institute of Dental and Craniofacial Research (NIDCR);   National Institute of Neurological Disorders and Stroke (NINDS);   Sorrento Therapeutics, Inc.
Suspended - verified May 2016

Biomarkers of Risk of Parkinson Disease

Conditions:   Parkinson Disease;   Autonomic Nervous System Diseases;   Pure Autonomic Failure
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016

Evaluating the Safety and Effectiveness of Bone Marrow Transplants in Children With Sickle Cell Disease (BMT CTN 0601)

Condition:   Sickle Cell Disease
Intervention:   Biological: Hematopoietic Stem Cell Transplantation
Sponsors:   Medical College of Wisconsin;   National Heart, Lung, and Blood Institute (NHLBI);   Blood and Marrow Transplant Clinical Trials Network;   National Cancer Institute (NCI);   National Marrow Donor Program;   Sickle Cell Disease Clinical Research Network
Active, not recruiting - verified May 2016

Air Muscle and Task Practice in Upper Limb Stroke Rehab

Condition:   Stroke
Intervention:   Device: robotic device
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed - verified April 2005

Neurobiological Principles Applied to the Rehabilitation of Stroke Patients

Condition:   Stroke
Interventions:   Drug: Sinemet, ritalin, amphetamine, and placebo;   Device: Transcranial magnetic stimulation (TMS);   Other: Combined drug treatment and TMS
Sponsors:   Emory University;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified May 2016

A Natural History Study of the Gangliosidoses

Conditions:   Tay-Sachs Disease;   Sandhoff Disease;   Late Onset Tay-Sachs Disease;   GM1 Gangliosidosis;   GM2 Gangliosidosis
Intervention:  
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified May 2016

A Comparison of Hemorrhagic and Ischemic Strokes Among Blacks and Whites

Conditions:   Ischemic Stroke;   TIA;   Hemorrhage
Intervention:  
Sponsors:   University of Cincinnati;   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified May 2016

Monitoring Patient Cerebro-Spinal Fluid Drainage With an Ultrasonic Flow Sensor

Condition:   Hydrocephalus
Intervention:  
Sponsors:   Transonic Systems Inc.;   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified May 2016

Effects of Vitamin D on Renin Expression in Hypertensive Patients

Conditions:   Hypertension;   Vitamin D Deficiency
Interventions:   Drug: calcitriol;   Drug: Placebo
Sponsor:   University of Utah
Terminated - verified March 2016

Stroke in Young Fabry Patients (sifap1): Frequency of Fabry Disease in Young Stroke Patients

Condition:   Cerebrovascular Accident
Intervention:   Other: No intervention
Sponsors:   University of Rostock;   Shire Human Genetic Therapies, Inc.
Completed - verified May 2016

E-Selectin Nasal Instillation to Prevent Secondary Stroke

Conditions:   Ischemic Attack, Transient;   Transient
Intervention:   Drug: Intransal instillation of E-selectin
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified May 2016

Vision Testing in Patients With Partial Seizures Receiving Either Lyrica or Placebo

Condition:   Epilepsies, Partial
Interventions:   Drug: Lyrica (pregabalin);   Drug: placebo
Sponsor:   Pfizer
Recruiting - verified May 2016

Registry of Unexplained Cardiac Arrest

Conditions:   Cardiac Arrest;   Long QT Syndrome;   Brugada Syndrome;   Catecholaminergi Polymorphic Ventricular Tachycardia;   Idiopathic VentricularFibrillation;   Early Repolarization Syndrome;   Arrhythmogenic Right Ventricular Cardiomyopathy
Intervention:  
Sponsors:   University of British Columbia;   Heart and Stroke Foundation of Ontario;   Boston Scientific Corporation;   Medtronic
Recruiting - verified May 2016

Reference Values for Plasma Catechols

Conditions:   Healthy Volunteers;   Normal Physiology
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016

Idebenone to Treat Friedreich's Ataxia

Condition:   Friedreich Ataxia
Intervention:   Drug: Idebenone
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 2016

Evaluation of Primary Chronic Autonomic Failure

Condition:   Autonomic Nervous System Diseases
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016

Study of Specimens Obtained During Epilepsy Surgery

Condition:   Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016

Natural History of Stroke: Cause and Development

Conditions:   Nervous System Disease;   Transient Ischemic Attack;   Neurologic Disorders;   Stroke;   Vascular Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016

Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

Condition:   Multiple Sclerosis
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2016