Prediabetes

Clinical Trial Finder

Many patients with prediabetes are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

A Mobile Phone-based Program for Adults With Prediabetes

Conditions:   Prediabetic State;   Diabetes Mellitus
Intervention:   Device: JOOL Health Mobile Phone Application
Sponsors:   University of Michigan;   Blue Cross Blue Shield of Michigan Foundation
Not yet recruiting - verified January 2017

TAU PET Imaging in Northern Manhattan Study of Metabolism and Mind

Conditions:   Diabetes Mellitus;   Alzheimer Dementia
Intervention:   Drug: 18F-THK-5351
Sponsors:   Columbia University;   National Institute on Aging (NIA)
Not yet recruiting - verified January 2017

Heidelberg Study on Diabetes and Complications

Condition:   Diabetes Complications
Intervention:   Other: No interventions are planned for this study.
Sponsor:   Heidelberg University
Recruiting - verified January 2017

Prevention of Diabetes in Overweight/Obese Preadolescent Children

Condition:   Overweight Children With Type 2 Diabetes Risk
Interventions:   Behavioral: lifestyle and psycho-educational program;   Other: Exercise plus lifestyle and psycho-educational program
Sponsors:   Basque Country University;   Spanish Ministry of Economy and Competitiveness
Not yet recruiting - verified January 2017

Pharmacogenomics of the Variability in the In Vivo Response to Glucocorticoids

Conditions:   Glucocorticoids Toxicity;   Glucose Intolerance
Intervention:   Drug: Prednisone
Sponsors:   Vanderbilt University Medical Center;   National Institute of General Medical Sciences (NIGMS)
Not yet recruiting - verified December 2016

Nutrigenomics, Overweight/Obesity and Weight Management Trial (NOW Trial)

Conditions:   Transplant-Related Disorder;   PreDiabetes;   Overweight and Obesity
Interventions:   Genetic: Personalized Nutrigenomics Testing (PNT);   Other: Standard Nutrition Intervention (SNI)
Sponsors:   Western University, Canada;   Nutrigenomix Inc.;   East Elgin Family Health Team;   Canadian Transplant Association
Not yet recruiting - verified January 2017

Effect of Dried Fruit on Cardiometabolic Risk Factors

Conditions:   Cardiovascular Diseases;   Metabolic Syndrome
Interventions:   Dietary Supplement: Dried Fruit;   Other: High Carbohydrate Snack
Sponsors:   Penn State University;   International Nut and Dried Fruit Council;   California Dried Plum Board
Not yet recruiting - verified January 2017

Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

Conditions:   Prediabetic State;   Atherosclerosis;   Metformin
Interventions:   Drug: Metformin XR;   Drug: Placebo
Sponsor:   VA Office of Research and Development
Not yet recruiting - verified January 2017

The Potential of Carnosine Supplementation in Optimising Cardiometabolic Health

Conditions:   Poor Glycemic Control;   Cardiovascular Risk Factors;   Cognitive Function 1, Social
Interventions:   Dietary Supplement: carnosine;   Drug: Placebo
Sponsor:   Monash University
Recruiting - verified January 2017

Evaluation of Prevent in Underserved Populations

Conditions:   Prediabetes;   Overweight;   Obesity
Intervention:   Behavioral: Prevent
Sponsors:   Omada Health, Inc.;   Kresge Foundation;   California HealthCare Foundation;   University of Southern California
Recruiting - verified January 2017

The Influence of Glucose Flux on Fat Synthesis in a Whole Body Calorimeter

Condition:   Type 2 Diabetes, Obesity, Prediabetes
Intervention:   Other: Breakfast, lunch, snack and dinner
Sponsor:   Clinical Nutrition Research Centre, Singapore
Active, not recruiting - verified January 2017

Retroperitoneal Lymph Node Dissection in Treating Patients With Stage I-IIA Testicular Seminoma

Conditions:   Lymphadenopathy;   Stage I Testicular Seminoma;   Stage II Testicular Seminoma
Interventions:   Other: Laboratory Biomarker Analysis;   Procedure: Retroperitoneal Lymph Node Dissection
Sponsors:   University of Southern California;   National Cancer Institute (NCI)
Recruiting - verified January 2017

Multiple Sclerosis: Associated Cardiometabolic Risks and Impact of Exercise Therapy

Conditions:   Multiple Sclerosis;   Healthy Controls
Intervention:   Behavioral: Physical exercise
Sponsor:   Bert Op't Eijnde
Completed - verified January 2017

Pharmacoepigenetics of Bipolar Disorder Treatment

Conditions:   Antipsychotic Agents;   Bipolar Disorder
Intervention:  
Sponsor:   Wayne State University
Recruiting - verified January 2017

Metformin in Co-morbid Diabetes or Prediabetes and Serious Mental Illness

Conditions:   Diabetes Mellitus, Type 2;   Schizophrenia
Interventions:   Drug: Metformin;   Drug: Placebo
Sponsor:   Centre for Addiction and Mental Health
Recruiting - verified January 2017

DNA Methylation and Gene Expression in Qataris With Type 2 Diabetes

Condition:   Type 2 Diabetes
Intervention:  
Sponsors:   Weill Medical College of Cornell University;   Hamad Medical Corporation;   Weill Cornell Medical College in Qatar
Recruiting - verified January 2017

Impact of Sitagliptin on Cardiovascular Exercise Performance in Type 2 Diabetes

Conditions:   Type 2 Diabetes;   Cardiovascular Disease
Interventions:   Drug: Sitagliptin;   Drug: Glimepiride;   Drug: Placebo;   Drug: Placebo
Sponsors:   University of Colorado, Denver;   Merck Sharp & Dohme Corp.
Recruiting - verified January 2017

Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury

Conditions:   Obstructive Sleep Apnea;   Hypercapnia;   Spinal Cord Injury
Interventions:   Device: BiPAP;   Device: BiPAP/AVAPS (Phillips Respironics)
Sponsor:   University of Michigan
Completed - verified January 2017

Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals

Condition:   Obesity
Intervention:   Drug: Roflumilast
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified January 10, 2017

Resveratrol and the Metabolic Syndrome

Conditions:   Obesity;   Insulin Resistance;   Metabolic Syndrome
Interventions:   Dietary Supplement: Placebo;   Dietary Supplement: Resveratrol
Sponsor:   Rockefeller University
Active, not recruiting - verified January 2017

Mood and Insulin Resistance in Adolescents At-Risk for Diabetes

Conditions:   Depression;   Impaired Glucose Tolerance
Interventions:   Other: The Blues Program;   Other: Hey Durham
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   National Institutes of Health Clinical Center (CC)
Completed - verified January 27, 2016

Mifepristone for Metabolic Syndrome

Conditions:   Endocrine Disease;   Diabetes
Intervention:   Drug: Mifepristone
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified December 16, 2016

Acarbose Cardiovascular Evaluation Trial

Conditions:   Coronary Heart Disease;   Acute Coronary Syndrome;   Impaired Glucose Tolerance;   Type 2 Diabetes Mellitus (T2DM)
Interventions:   Drug: Acarbose;   Drug: Matching Placebo
Sponsors:   University of Oxford;   Bayer
Active, not recruiting - verified January 2017

Pilot Study of Mitochondrial Biology in Human Platelets

Conditions:   Insulin Resistance;   Diabetes
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified October 24, 2011

Relation of White Blood Cell Function to Diabetes

Condition:   Diabetes
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified October 19, 2009

Insulin Resistance and Atherosclerosis in Women With Lupus

Conditions:   Systemic Lupus Erythematosus;   Insulin Resistance;   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Completed - verified April 29, 2016

Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors and Hematopoietic Stem Cell Transplant Recipients

Conditions:   Hypopituitarism;   Hypogonadism;   Thyroid Dysfunction;   Bone Diseases, Metabolic
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified October 31, 2016

Insulin Secretory Defects in Pima Indians at High Risk for NIDDM

Condition:   NIDDM
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed - verified August 16, 2011

Cross-Sectional and Longitudinal Studies of "Pre-Diabetes" in the Pima Indians

Condition:   Diabetes
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified December 6, 2016

A Study of the Function of Hormones Present In Taste Buds

Conditions:   Diabetes;   Obesity;   Pre-Diabetes;   Metabolic Syndrome
Intervention:  
Sponsor:   National Institute on Aging (NIA)
Completed - verified January 2, 2015

Rosiglitazone to Reverse Metabolic Defects in Diabetes

Conditions:   Diabetes Mellitus, Type II;   Insulin Resistance
Interventions:   Procedure: Exercise cardiopulmonary metabolic testing;   Procedure: Skeletal muscle biopsy;   Procedure: Brachial artery reactivity testing
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified September 3, 2008

Rosiglitazone to Treat Patients With Heart Failure and Glucose Intolerance or Type II Diabetes

Condition:   Congestive Heart Failure
Interventions:   Drug: Avandia (Rosiglitazone);   Drug: Avanclia (Rosiqlitazone)
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 11, 2007