Clinical Trial Finder

Many patients with prediabetes are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Effects of Almonds on Insulin Sensitivity in Prediabetes

Condition:   PreDiabetes
Interventions:   Other: 1.5 oz of whole, natural almonds;   Other: Low-fat, high refined starches/sugars
Sponsors:   Midwest Center for Metabolic and Cardiovascular Research;   Almond Board of California
Recruiting - verified April 2017

Gelesis Glycemic Index Study

Conditions:   Obesity;   Diabetes;   PreDiabetes
Interventions:   Device: Gelesis200;   Other: Water, only (placebo)
Sponsors:   Gelesis, Inc.;   inVentiv Health Clinique
Active, not recruiting - verified April 2017

Sitagliptin Improved Beta Cell Function and Prevented a Conversion Rate to Impaired Glucose Tolerance and Type 2 Diabetes in Metformin Intolerant Obese Women With Polycystic Ovary Syndrome

Condition:   PCOS
Interventions:   Drug: Sitagliptin;   Behavioral: Lifestyle intervention
Sponsor:   University Medical Centre Ljubljana
Completed - verified April 2017

Study: Diet and Exercise Study to Improve Brain Blood Flow: Blood Flow Improvement Trial

Condition:   PreDiabetes
Intervention:   Behavioral: Diet and Exercise
Sponsor:   University of Wisconsin, Madison
Recruiting - verified April 2017

Induced and Controlled Dietary Ketosis as a Regulator of Obesity and Metabolic Syndrome Pathologies

Conditions:   Metabolic Syndrome;   Diabetes Mellitus, Type 2;   Pre Diabetes
Intervention:   Behavioral: Dietary Ketosis: Regulator of Obesity and Metabolic Syndrome
Sponsors:   Bristlecone Behavioral Health, Inc.;   University of Minnesota - Clinical and Translational Science Institute
Completed - verified April 2017

A Mobile Phone-based Program for Adults With Prediabetes

Conditions:   Prediabetic State;   Diabetes Mellitus
Intervention:   Device: JOOL Health Mobile Phone Application
Sponsors:   University of Michigan;   Blue Cross Blue Shield of Michigan Foundation
Not yet recruiting - verified April 2017

TAU PET Imaging in Northern Manhattan Study of Metabolism and Mind

Conditions:   Diabetes Mellitus;   Alzheimer Dementia
Intervention:   Drug: 18F-THK-5351
Sponsors:   Columbia University;   National Institute on Aging (NIA)
Not yet recruiting - verified April 2017

Integrating Community Health Workers to Improve Diabetes Prevention

Condition:   Diabetes Mellitus
Interventions:   Behavioral: CHW Training;   Behavioral: Data Only
Sponsor:   New York University School of Medicine
Not yet recruiting - verified April 2017

Effect of a Modified Ketogenic-Mediterranean Diet on Alzheimer's Disease

Conditions:   Mild Cognitive Impairment;   Insulin Resistance
Interventions:   Other: Low-Carbohydrate Diet;   Other: Low-Fat Diet
Sponsor:   Wake Forest University Health Sciences
Active, not recruiting - verified April 2017

A Trial Investigating Safety, Tolerability, PK and PD for Multiple Doses of NNC9204-0530 in Male and Female Subjects Being Overweight or With Obesity

Conditions:   Metabolism and Nutrition Disorder;   Obesity
Interventions:   Drug: NNC9204-0530;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Active, not recruiting - verified April 2017

Apalutamide Plus Intermittent Hormone Therapy Versus Intermittent Hormone Therapy Alone in Prostate Cancer

Condition:   Prostate Cancer
Interventions:   Drug: Apalutamide;   Drug: IHT
Sponsors:   Robert J Amato;   Janssen Scientific Affairs, LLC
Not yet recruiting - verified April 2017

Meta-analyses of the Effect of 'Catalytic' Doses of Fructose and Its Epimers on Carbohydrate Metabolism

Conditions:   Overweight;   Obesity;   Dysglycemia;   Prediabetes;   Metabolic Syndrome;   Type 2 Diabetes
Intervention:   Other: fructose, allulose, tagatose, or sorbose
Sponsors:   University of Toronto;   Canadian Diabetes Association;   The Physicians' Services Incorporated Foundation;   Banting & Best Diabetes Centre;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting - verified April 2017

Smart Technology for Weight Loss and Metabolic Health

Conditions:   Obesity;   Overweight;   Prediabetes;   Weight Loss;   Lifestyle
Interventions:   Device: Wearable technology, smartscale;   Behavioral: Smartphone applications;   Behavioral: Standard Weight Management Visits
Sponsors:   Temple University;   The Obesity Treatment Foundation
Active, not recruiting - verified April 2017

A Pilot Study to Assess the Safety of Oral Insulin in Patients With Nonalcolholic Steatohepatitis (NASH)

Condition:   Non-alcoholic Fatty Liver Disease
Intervention:   Biological: Oral Insulin
Sponsors:   Oramed, Ltd.;   Hadassah Medical Organization
Not yet recruiting - verified April 2017

The Snack Study: The Feasibility of Changing Night-time Food Choices to Improve Glucose Tolerance in Pregnancy

Conditions:   Glucose Intolerance;   Obesity
Intervention:   Behavioral: Low glycemic load snacks
Sponsors:   University of Alabama at Birmingham;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified April 2017

Feasibility of an Interval Exercise and Nutrition Intervention to Reduce Cardiovascular Disease Risk Factors

Conditions:   Pre-Diabetic;   Overweight;   Obesity
Intervention:   Other: Exercise & Dietary Supplement
Sponsor:   University of North Carolina, Chapel Hill
Completed - verified April 2017

Macronutrient Effects on Alzheimer's Disease (MEAL-2)

Conditions:   Prediabetic State;   Insulin Resistance;   Middle Age;   Prehypertension;   Mild Cognitive Impairment
Interventions:   Other: Low Diet;   Other: High Diet
Sponsor:   Wake Forest University Health Sciences
Completed - verified April 2017

Effect of Dietary Habits on Metabolic Health

Conditions:   Overweight;   Obesity;   Prediabetes;   Meals
Intervention:   Behavioral: Meal schedule
Sponsors:   Brigham and Women's Hospital;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified April 2017

Piedmont Aging, Cognition & Exercise Study-2

Conditions:   Mild Cognitive Impairment;   Prediabetes
Interventions:   Behavioral: Exercise/Aerobic;   Behavioral: Exercise/Stretching
Sponsors:   Wake Forest University;   American Diabetes Association
Completed - verified April 2017

Role of Growth Hormone Antagonism in Modulating Insulin Sensitivity in Subjects With Pre-diabetes

Conditions:   Diabetes;   Metabolic Syndrome;   Insulin Resistance
Intervention:   Drug: pegvisomant
Sponsors:   University of California, San Francisco;   San Francisco General Hospital
Completed - verified April 2017

Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals

Condition:   Obesity
Intervention:   Drug: Roflumilast
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified February 9, 2017

Early Screening and Treatment of Women With Prediabetes in Pregnancy

Conditions:   Diabetes;   Pregnancy
Interventions:   Other: Minimum intervention control group;   Other: Treatment for glucose intolerance
Sponsors:   Stanford University;   Santa Clara Valley Medical Center
Active, not recruiting - verified April 2017

Mood and Insulin Resistance in Adolescents At-Risk for Diabetes

Conditions:   Depression;   Impaired Glucose Tolerance
Interventions:   Other: The Blues Program;   Other: Hey Durham
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   National Institutes of Health Clinical Center (CC)
Completed - verified January 27, 2016

Mifepristone for Metabolic Syndrome

Conditions:   Endocrine Disease;   Diabetes
Intervention:   Drug: Mifepristone
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified December 16, 2016

Effect of Dietary Glycemic Index on Beta-cell Function

Conditions:   Impaired Glucose Tolerance;   Oxidative Stress;   Prediabetes;   Impaired Fasting Glucose
Interventions:   Other: low glycemic index diet;   Other: high glycemic index diet plus placebo;   Drug: high glycemic index diet plus N-acetylcysteine
Sponsors:   Seattle Institute for Biomedical and Clinical Research;   VA Puget Sound Health Care System
Recruiting - verified April 2017

Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)

Condition:   Atherosclerosis
Interventions:   Drug: Canakinumab;   Drug: Placebo
Sponsor:   Novartis Pharmaceuticals
Active, not recruiting - verified April 2017

Postpartum Weight Loss and Exercise (PRIDE)

Conditions:   Gestational Diabetes;   Glucose Intolerance
Interventions:   Behavioral: Non-intervention group;   Behavioral: Face to face;   Behavioral: Telehelath Group
Sponsors:   Pennington Biomedical Research Center;   THE C.B. AND IRENE PENNINGTON FOUNDATION
Active, not recruiting - verified April 2017

Insulin Resistance and Atherosclerosis in Women With Lupus

Conditions:   Systemic Lupus Erythematosus;   Insulin Resistance;   Atherosclerosis
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Completed - verified April 29, 2016

Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth

Conditions:   Impaired Glucose Tolerance;   Pre-diabetes;   Childhood Obesity;   Insulin Resistance;   Metabolic Syndrome
Sponsors:   Yale University;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed - verified April 2017

Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors and Hematopoietic Stem Cell Transplant Recipients

Conditions:   Hypopituitarism;   Hypogonadism;   Thyroid Dysfunction;   Bone Diseases, Metabolic
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified October 31, 2016

Cross-Sectional and Longitudinal Studies of "Pre-Diabetes" in the Pima Indians

Condition:   Diabetes
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 16, 2017

A Study of the Function of Hormones Present In Taste Buds

Conditions:   Diabetes;   Obesity;   Pre-Diabetes;   Metabolic Syndrome
Sponsor:   National Institute on Aging (NIA)
Completed - verified January 2, 2015