Mitral Valve Regurgitation

Clinical Trial Finder

Many patients with mitral valve regurgitation are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

PARTNER 3 Trial - Mitral Valve in Valve

Conditions:   Mitral Valve Insufficiency;   Mitral Valve Disease;   Mitral Valve Regurgitation;   Heart Failure
Intervention:   Device: Edwards SAPIEN 3 transcatheter valve, Model 9600TFX
Sponsor:   Edwards Lifesciences
Not yet recruiting - verified June 2017

Bridging Thrombolysis Versus Direct Mechanical Thrombectomy in Acute Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Device: Stent-retriever thrombectomy with revascularization device of the Solitaire™ type;   Drug: Intravenous thrombolysis with recombinant tissue-type plasminogen activator (IV t-PA)
Sponsors:   University Hospital Inselspital, Berne;   Medtronic
Not yet recruiting - verified June 2017

Effects of Fructose/Glucose-rich Diet on Brown Fat in Healthy Subjects (GB7)

Condition:   Type2 Diabetes
Interventions:   Dietary Supplement: Diet;   Other: cold exposure;   Radiation: 18FDG;   Radiation: 11C-acetate;   Radiation: [3-3H]-glucose;   Other: [U-13C]-palmitate;   Other: 2H-Glycerol;   Device: MRI/MRS;   Device: Electromyogram (EMG);   Device: DXA;   Device: Indirect calorimetry
Sponsors:   Université de Sherbrooke;   McMaster University;   University of Ottawa
Recruiting - verified June 2017

Dabigatran in Patients With Atrial Fibrillation and Mitral Biological Prostheses

Conditions:   Mitral Valve Stenosis and Insufficiency;   Atrial Fibrillation
Interventions:   Drug: Dabigatran Etexilate;   Drug: Warfarin
Sponsor:   Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Enrolling by invitation - verified June 2017

Rehabilitating (Stroke-induced) Apraxia With Direct Current Stimulation

Conditions:   Stroke;   Apraxia
Interventions:   Device: anodal tDCS;   Device: sham tDCS
Sponsor:   University of Cologne
Not yet recruiting - verified June 2017

Long Term Follow Up for CTSN Mitral Valve Repair Studies

Conditions:   Mitral Valve Insufficiency;   Coronary Artery Disease
Interventions:   Other: MV Repair;   Other: MV Replacement;   Other: CABG
Sponsors:   Icahn School of Medicine at Mount Sinai;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research (CIHR)
Enrolling by invitation - verified June 2017

Tiara™ Transcatheter Mitral Valve Replacement Study

Condition:   Mitral Valve Regurgitation
Intervention:   Device: TIARA valve and transapical delivery system
Sponsor:   Neovasc Inc.
Recruiting - verified January 2017

Study of Allogeneic Umbilical Cord Blood Infusion for Adults With Ischemic Stroke

Conditions:   Stroke;   Stroke, Acute;   Brain Injury, Acute
Interventions:   Biological: Umbilical Cord Blood;   Other: Placebo
Sponsors:   Joanne Kurtzberg, MD;   The Marcus Foundation;   Emory University;   M.D. Anderson Cancer Center
Recruiting - verified June 2017

Effectiveness and Safety of SAR156597 in Treating Diffuse Systemic Sclerosis

Condition:   Systemic Sclerosis
Interventions:   Drug: SAR156597 (ACT14604);   Drug: Placebo
Sponsor:   Sanofi
Recruiting - verified June 2017

A Study Comparing the Effect of Albiglutide With Exenatide on Regional Brain Activity Related to Nausea in Healthy Subjects

Condition:   Diabetes Mellitus
Interventions:   Drug: Albiglutide 50mg;   Drug: Albiglutide matching placebo;   Drug: Exenatide 10microgram;   Drug: Exenatide placebo (saline)
Sponsors:   GlaxoSmithKline;   The General Hospital Corporation d/b/a Massachusetts General Hospital
Active, not recruiting - verified June 2017

A Carbohydrate-restricted Diet to Reverse Fatty Liver in Adolescents With Obesity

Conditions:   Non-alcoholic Fatty Liver Disease;   Childhood Obesity;   Insulin Resistance
Interventions:   Other: Carbohydrate-restricted diet;   Other: Control, low-fat diet
Sponsor:   University of Alabama at Birmingham
Recruiting - verified June 2017

Impact of Remote Ischemic Postconditioning on Autonomic Function in Stroke Patients

Condition:   Ischemic Stroke
Interventions:   Procedure: remote ischemic postconditioning;   Procedure: sham remote ischemic postconditioning
Sponsor:   Guangzhou University of Traditional Chinese Medicine
Recruiting - verified June 2017

Safety and Efficacy of Intravenous Natalizumab in Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke
Interventions:   Drug: natalizumab;   Drug: Placebo
Sponsor:   Biogen
Recruiting - verified June 2017

Determine the Effective Dose 95 of Sevoflurane in Adult Patients

Conditions:   Mitral Stenosis;   Mitral Insufficiency;   Tricuspid Stenosis;   Tricuspid Insufficiency
Sponsor:   Instituto Dante Pazzanese de Cardiologia
Recruiting - verified June 2017

Reoxygenation After Cardiac Arrest II (REOX II Study)

Condition:   Cardiac Arrest
Intervention:   Other: Protocol for rapid FiO2 optimization
Sponsors:   The Cooper Health System;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified June 2017

A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis

Condition:   Scleroderma, Systemic
Interventions:   Drug: Nintedanib;   Drug: Placebo
Sponsor:   Boehringer Ingelheim
Recruiting - verified June 2017

MRI Study of the Structural and Functional Rehabilitation in the Cerebral Infarction Patients With Diabetes

Conditions:   Cerebral Stroke;   Diabetes Mellitus
Sponsor:   Zhejiang University
Recruiting - verified June 2017

Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: Tenecteplase;   Drug: Tissue Plasminogen Activator
Sponsors:   Neuroscience Trials Australia;   The Florey Institute of Neuroscience and Mental Health
Recruiting - verified June 2017

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, or Hypermutated Brain Tumors

Conditions:   Constitutional Mismatch Repair Deficiency Syndrome;   Diffuse Intrinsic Pontine Glioma;   Lynch Syndrome;   Malignant Glioma;   Recurrent Brain Neoplasm;   Refractory Brain Neoplasm
Interventions:   Procedure: Diffusion Tensor Imaging;   Procedure: Diffusion Weighted Imaging;   Procedure: Dynamic Contrast-Enhanced Magnetic Resonance Imaging;   Procedure: Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging;   Other: Laboratory Biomarker Analysis;   Procedure: Magnetic Resonance Spectroscopic Imaging;   Biological: Pembrolizumab;   Procedure: Perfusion Magnetic Resonance Imaging
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified June 2017

Endovascular Therapy for Acute Ischemic Stroke Trial

Condition:   Ischemic Stroke
Intervention:   Device: Interventional treatment with Solitaire
Sponsor:   Ministry of Science and Technology of the People´s Republic of China
Completed - verified June 2017

Metabolic Anomolies Associated With the 6 Month Clinical Evolution of Patients Suffering From Motor Conversion Disorder

Condition:   Conversion Disorder
Intervention:   Device: PET CT 18 FDG
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Recruiting - verified June 2017

A Study of Subcutaneous Abatacept to Treat Diffuse Cutaneous Systemic Sclerosis

Condition:   Diffuse Cutaneous Systemic Sclerosis
Interventions:   Drug: Abatacept;   Drug: Placebo
Sponsors:   Dinesh Khanna, MD, MS;   Bristol-Myers Squibb;   National Institute of Allergy and Infectious Diseases (NIAID)
Active, not recruiting - verified June 2017

Border Zone Stereotactic Radiosurgery With Bevacizumab in Patients With Glioblastoma Multiforme

Conditions:   Glioblastoma Multiforme;   Glioblastoma - Category
Interventions:   Drug: Bevacizumab;   Procedure: Magnetic Resonance Spectroscopy (MRS);   Procedure: Border Zone Stereotactic Radiosurgery (BZ-SRS)
Sponsors:   Ajay Niranjan;   Genentech, Inc.
Recruiting - verified June 2017

STOP-AUST: The Spot Sign and Tranexamic Acid On Preventing ICH Growth - AUStralasia Trial

Conditions:   Intracerebral Haemorrhage;   Stroke
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsor:   Neuroscience Trials Australia
Recruiting - verified June 2017

TRUfill®'s Line in Intracranial aNeurysm Embolisation

Condition:   Aneurysms
Sponsor:   Codman & Shurtleff
Completed - verified June 2017

Stroke Adverse Outcome is Associated With Nosocomial Infections: PCTus- Guided Antibacterial Therapy in Severe Ischemic Stroke Patients (STRAWINSKI)

Condition:   Ischemic Stroke
Intervention:   Device: Procalcitonin assay - B.R.A.H.M.S PCT ultrasensitive Kryptor
Sponsors:   Charite University, Berlin, Germany;   Brahms AG;   NeuroCure Clinical Research Center - Charité (Berlin)
Completed - verified June 2017

A Pilot Clinical Trial of Exendin-4 in Alzheimer's Disease

Conditions:   Alzheimer's Disease;   Mild Cognitive Impairment
Intervention:   Drug: Exendin-4 (Exenatide)
Sponsor:   National Institute on Aging (NIA)
Completed - verified June 7, 2017

Quantitative Imaging and Proton Spectroscopy in Multiple Sclerosis

Condition:   Multiple Sclerosis
Intervention:   Device: Magnetic Resonance Imaging
Sponsors:   New York University School of Medicine;   National Institute of Neurological Disorders and Stroke (NINDS)
Terminated - verified June 2017

A Clinical Study to Assess the Safety, Tolerability and Pharmacokinetics of Oral SRT2104 Capsules Administered to Healthy Elderly Subjects for 28 Days

Condition:   Atrophy, Muscular
Interventions:   Drug: Placebo;   Drug: SRT2104
Sponsor:   GlaxoSmithKline
Completed - verified June 2017

An fMRI Study of Self-regulation in Adolescents With Bulimia Nervosa

Condition:   Eating Disorders
Interventions:   Other: MRI;   Behavioral: Neuropsychological Testing
Sponsors:   New York State Psychiatric Institute;   National Institute of Mental Health (NIMH)
Active, not recruiting - verified June 2017