Mitral Valve Regurgitation

Clinical Trial Finder

Many patients with mitral valve regurgitation are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia

Condition:   Brain Hypoxia
Intervention:   Device: Mild Hypoxia
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Not yet recruiting - verified June 2015

Effect of Rosuvastatin on Prognosis of Clinical Response in Acute Ischemic Stroke Patients(REPAIRS)

Condition:   Infarction, Anterior Cerebral Artery
Intervention:   Drug: Rosuvastatin
Sponsors:   Second Affiliated Hospital of Soochow University;   Taicang No.1 People’s hospital;   AstraZeneca;   National Natural Science Foundation of China
Not yet recruiting - verified June 2015

Arousal-Biofeedback for the Treatment of Aggressive Behavior in Children and Adolescents

Conditions:   Aggression;   Conduct Disorder;   Oppositional Defiant Disorder
Interventions:   Behavioral: Individualized Arousal-Biofeedback;   Behavioral: Treatment as usual
Sponsors:   Central Institute of Mental Health, Mannheim;   Radboud University;   University of Zurich
Not yet recruiting - verified June 2015

"Mobile Stroke Unit"-Concept for Delivery of Specialized Acute Stroke Care to Patients in Remote Areas

Condition:   Acute Stroke
Interventions:   Device: MSU-based stroke management;   Device: Control stroke management
Sponsor:   University Hospital, Saarland
Recruiting - verified July 2015

A Study of the Efficacy and Safety of Tocilizumab in Participants With Systemic Sclerosis (SSc) [focuSSced]

Condition:   Sclerosis, Systemic
Interventions:   Drug: Placebo;   Drug: Tocilizumab
Sponsor:   Hoffmann-La Roche
Not yet recruiting - verified July 2015

Study of Spirit Pass in Newborn and Patient

Conditions:   Pain;   Stress
Intervention:   Other: laying of hands (Spiritist "passe")
Sponsor:   Universidade Federal do Triangulo Mineiro
Completed - verified June 2015

Biomarker Study of EPI-589 in Parkinson's Disease

Condition:   Parkinson's Disease
Intervention:   Drug: EPI-589
Sponsor:   Edison Pharmaceuticals Inc
Not yet recruiting - verified June 2015

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas or Diffuse Intrinsic Pontine Gliomas

Conditions:   Diffuse Intrinsic Pontine Glioma;   Malignant Glioma;   Recurrent Childhood Brain Neoplasm
Interventions:   Procedure: Diffusion Tensor Imaging;   Procedure: Diffusion Weighted Imaging;   Procedure: Dynamic Contrast-Enhanced Magnetic Resonance Imaging;   Procedure: Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging;   Other: Laboratory Biomarker Analysis;   Procedure: Magnetic Resonance Spectroscopic Imaging;   Biological: Pembrolizumab;   Procedure: Perfusion Magnetic Resonance Imaging
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified June 2015

Evaluation of Long-term Efficacy of Treatment With Lamazym

Condition:   Alpha-Mannosidosis
Intervention:   Drug: Lamazym
Sponsor:   Zymenex A/S
Active, not recruiting - verified June 2015

Trial of Topical C-82 in Systemic Sclerosis - A Phase I/II Biomarker and Safety Trial

Condition:   Systemic Scleroderma
Interventions:   Drug: C-82 Topical Gel, 1%;   Drug: C-82 Topical Gel, Placebo
Sponsor:   Prism Pharma Co., Ltd.
Recruiting - verified June 2015

Efficacy and Safety of Riociguat in Patients With Systemic Sclerosis

Condition:   Scleroderma, Systemic
Interventions:   Drug: Riociguat (Adempas, BAY63-2521);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified June 2015

Decompressive Hemicraniectomy in Intracerebral Hemorrhage

Condition:   Cerebral Hemorrhage
Interventions:   Procedure: Decompressive craniectomy (DC) and best medical treatment;   Procedure: Best medical treatment
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified June 2015

Trevo and Medical Management Versus Medical Management Alone in Wake Up and Late Presenting Strokes

Condition:   Ischemic Stroke
Interventions:   Device: Trevo Thrombectomy Procedure;   Other: Medical Management
Sponsor:   Stryker Neurovascular
Recruiting - verified June 2015

Glutamate-Glutamine Cycling (VCYC) During Cocaine Abstinence Using 13C-MRS

Condition:   Cocaine Dependence
Interventions:   Drug: N-acetyl cysteine;   Drug: riluzole;   Drug: pentoxifylline;   Drug: 13C MRS;   Behavioral: Continued abstinence
Sponsor:   Yale University
Recruiting - verified June 2015

Sedation vs. Intubation for Endovascular Stroke TreAtment

Condition:   Acute Ischemic Stroke
Intervention:   Procedure: Endovascular recanalisation
Sponsor:   University Hospital Heidelberg
Recruiting - verified June 2015

Pancreatic Resectability in Cancers With Known Limited Extension (PRICKLE)

Condition:   Pancreatic Adenocarcinoma
Interventions:   Drug: Abraxane;   Drug: Gemcitabine
Sponsors:   CCTU- Cancer Theme;   Cambridge University Hospitals NHS Foundation Trust;   Cancer Research UK;   Celgene Corporation
Recruiting - verified June 2015

A Study of the Efficacy and Safety of Activase (Alteplase) in Patients With Mild Stroke (PRISMS)

Condition:   Brain Ischemia
Interventions:   Drug: alteplase [Activase];   Drug: alteplase placebo;   Drug: aspirin;   Drug: aspirin placebo
Sponsor:   Genentech, Inc.
Recruiting - verified July 2015

Study to Determine if Enhancing Glutamate Transporter Function Produces Antidepressant Effects in People With Major Depressive Disorder

Condition:   Depression
Interventions:   Drug: Diazoxide;   Drug: Placebo
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting - verified June 2015

Trevo® Retriever Registry Post Market Surveillance

Condition:   Ischemic Stroke
Sponsor:   Stryker Neurovascular
Recruiting - verified June 2015

Surgical Treatment of Hypertrophic Obstructive Cardiomyopathy With Severe Mitral Insufficiency.

Condition:   Hypertrophic Obstructive Cardiomyopathy
Interventions:   Procedure: myoectomy;   Procedure: Mitral valve surgery;   Procedure: Mitral valve surgery
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Completed - verified July 2015

Placebo Controlled Study of VS-6063 in Subjects With Malignant Pleural Mesothelioma

Condition:   Malignant Pleural Mesothelioma
Interventions:   Drug: defactinib (VS-6063);   Drug: Placebo
Sponsor:   Verastem, Inc.
Recruiting - verified June 2015

ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)

Conditions:   Aortic Stenosis;   Mitral Stenosis;   Aortic Valve Insufficiency;   Mitral Valve Insufficiency;   Heart Failure
Intervention:   Device: Edwards Aortic and Mitral Bioprostheses Models 11000A and 11000M
Sponsor:   Edwards Lifesciences
Recruiting - verified June 2015

A Study to Evaluate the Effect of Aleglitazar on Cardiac Energetics and Function in Patients With Type 2 Diabetes Mellitus and no History of Coronary Artery Disease

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: aleglitazar;   Drug: placebo
Sponsor:   Hoffmann-La Roche
Completed - verified July 2015

Danhong Injection in the Treatment of Acute Ischemic Stroke

Condition:   Acute Stroke
Interventions:   Drug: Danhong injection;   Procedure: Standard medical care;   Drug: placebo
Sponsors:   China  Academy of Chinese Medical Sciences;   China: State Food and Drug Administration
Recruiting - verified June 2015

Magnetic Resonance Spectroscopy in Autonomic Failure

Conditions:   Pure Autonomic Failure;   Multiple System Atrophy
Intervention:   Procedure: Magnetic Resonance Spectroscopy Imaging
Sponsor:   Vanderbilt University
Recruiting - verified June 2015

A Study of RoActemra/Actemra (Tocilizumab) Versus Placebo in Patients With Systemic Sclerosis

Condition:   Sclerosis, Systemic
Interventions:   Drug: Placebo;   Drug: tocilizumab [RoActemra/Actemra];   Drug: tocilizumab [RoActemra/Actemra]
Sponsor:   Hoffmann-La Roche
Completed - verified July 2015

RYGB and the Gastric Adipose Axis

Condition:   Obesity
Interventions:   Drug: Insulin;   Drug: D-Glucose;   Drug: Human ghrelin;   Procedure: Adipose and muscle biopsies;   Procedure: Adipose tissue microdialysis;   Procedure: MRI;   Procedure: MRS;   Radiation: DXA;   Procedure: Hyperinsulinemic-euglycemic clamp;   Procedure: Blood draws;   Other: Caloric restriction
Sponsors:   Vanderbilt University;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Enrolling by invitation - verified June 2015

Early Percutaneous Mitral Intervention in Asymptomatic Moderate Mitral Stenosis

Condition:   Moderate Mitral Stenosis
Intervention:   Procedure: Percutaneous Mitral Commissurotomy
Sponsor:   Asan Medical Center
Recruiting - verified June 2015

A Study of RO5093151 in Patients With Non-Alcoholic Fatty Liver Disease

Condition:   Fatty Liver, Non-alcoholic Fatty Liver Disease, NAFLD
Interventions:   Drug: Placebo;   Drug: RO5093151
Sponsor:   Hoffmann-La Roche
Completed - verified July 2015

Effects of Metreleptin in Type 1 Diabetes Mellitus

Condition:   Type 1 Diabetes
Intervention:   Drug: Leptin  ( Metreleptin )
Sponsors:   University of Texas Southwestern Medical Center;   Juvenile Diabetes Research Foundation;   Amylin Pharmaceuticals, LLC.
Terminated - verified June 2015

Magna® Mitral Pericardial Bioprostheses Post-Approval Study Protocol

Conditions:   Coronary Artery Disease;   Mitral Valve Regurgitation;   Mitral Valve Incompetence;   Heart Failure
Sponsor:   Edwards Lifesciences
Recruiting - verified July 2015

Phase I Study of Intensity Modulated Radiation Therapy for Prostate Cancer

Condition:   Prostate Cancer
Intervention:   Radiation: Radiation
Sponsor:   National Cancer Institute (NCI)
Completed - verified June 2015

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