Mitral Valve Regurgitation Also called: Mitral Regurgitation (MR)

Clinical Trial Finder

Many patients with mitral valve regurgitation are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Epicardial Mitral Touch System for Mitral Insufficiency

Conditions:   Ischemic Mitral Regurgitation;   Functional Mitral Regurgitation
Intervention:   Device: Implant an epicardial device to reshape the mitral valve annulus
Sponsor:   Mitre Medical Corp.
Not yet recruiting

Left Chamber Function in Mitral Regurgitation and Predicting Outcome After Replacement and Targeting for Early Surgery

Condition:   Mitral Regurgitation
Interventions:   Procedure: Mitral valve replacement;   Device: Speckle tracking echocardiography
Sponsor:   Assiut University
Not yet recruiting

The CARILLON Trial - Assessment of the Carillon® Mitral Contour System® in Treating Functional Mitral Regurgitation Associated With Heart Failure

Conditions:   Functional Mitral Regurgitation;   Heart Failure;   Mitral Valve Insufficiency;   Heart Diseases;   Cardiovascular Diseases;   Heart Valve Diseases
Interventions:   Device: Carillon Mitral Contour System;   Other: Guideline Directed Heart Failure Medication
Sponsor:   Cardiac Dimensions, Inc.
Active, not recruiting

Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Conditions:   Mitral Regurgitation;   Mitral Insufficiency;   Mitral Valve Insufficiency;   Cardiovascular Diseases;   Valve Disease, Heart;   Heart Valve Diseases;   Functional Mitral Regurgitation;   Degenerative Mitral Valve Disease
Interventions:   Device: Tendyne Mitral Valve System;   Device: MitraClip System
Sponsor:   Abbott Medical Devices
Recruiting

Percutaneous Mitral Valve Repair in Cardiogenic Shock: Mitra-Shock Study

Condition:   Mitral Regurgitation Functional
Intervention:   Device: MitraClip implantation
Sponsor:   IRCCS San Raffaele
Recruiting

Functional Effects of Botox on the Brain Using MRS and fMRI

Condition:   Healthy
Intervention:   Drug: onabotulinumtoxinA
Sponsors:   University of California, Irvine;   Allergan
Completed

Pharmaco-Magnetic Resonance Spectroscopy (MRS) Study of Clavulanic Acid

Condition:   Cocaine Dependence
Interventions:   Drug: Clavulanic Acid Only Product;   Other: Placebo
Sponsors:   Temple University;   Beth Israel Deaconess Medical Center;   University of Pennsylvania Perelman School of Medicine
Not yet recruiting

A Phase 3 Study of KHK4827 in Patients With Systemic Sclerosis

Condition:   Moderate to Severe Systemic Sclerosis
Interventions:   Drug: KHK4827;   Drug: Placebo
Sponsor:   Kyowa Kirin Co., Ltd.
Active, not recruiting

Establishment and Evaluation of Multimodal Image Recognition System of Glioma Based on Deep Learning

Condition:   Glioma
Intervention:   Device: PET/CT, H-MRS and MRI
Sponsor:   Tao Xin
Not yet recruiting

Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke

Condition:   Stroke
Interventions:   Device: Remote Ischemic Conditioning treatment;   Drug: Guideline-based therapy
Sponsor:   General Hospital of Shenyang Military Region
Recruiting

Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle

Conditions:   Brain Mapping;   Healthy Volunteer
Interventions:   Device: MAGNETOM 7 Tesla scanner;   Device: 1Tx32Rx head coil;   Device: Phosphorous (31P) surface coils
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting

Long-term Follow-up After Stroke (The LAST-long Trial)

Condition:   Stroke
Interventions:   Behavioral: Intervention;   Behavioral: Control
Sponsors:   Norwegian University of Science and Technology;   St. Olavs Hospital;   University Hospital, Akershus
Recruiting

ASSIST Registry Studying Various Operator Techniques

Condition:   Ischemic Stroke
Intervention:   Device: Mechanical Thrombectomy
Sponsor:   Stryker Neurovascular
Recruiting

SC IL-1Ra in SAH - Phase III Trial (SCIL)

Condition:   Subarachnoid Hemorrhage
Interventions:   Drug: IL-1Ra;   Drug: IL-1Ra Placebo
Sponsors:   University of Manchester;   National Institute for Health Research, United Kingdom;   Manchester Academic Health Science Centre;   Salford Royal NHS Foundation Trust
Active, not recruiting

Multi-center Trial of ValveClamp

Condition:   Evaluate the Safety and Efficacy of the ValveClamp
Intervention:   Device: ValveClamp
Sponsor:   Shanghai Zhongshan Hospital
Recruiting

Comparison of PET and Proton MRS Imaging to Evaluate Pediatric Brain Tumor Activity

Condition:   Brain Tumors
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Completed

SAHaRA: A Randomized Controlled Trial

Condition:   Subarachnoid Hemorrhage, Aneurysmal
Interventions:   Other: Liberal RBC Transfusion Strategy;   Other: Restrictive RBC Transfusion Strategy
Sponsors:   Ottawa Hospital Research Institute;   Canadian Institutes of Health Research (CIHR)
Recruiting

5-HTP and Creatine for Depression

Condition:   Major Depressive Disorder
Interventions:   Drug: 5-Hydroxytryptophan 100 MG;   Drug: Creatine monohydrate;   Drug: placebo matched to 5-HTP
Sponsor:   University of Utah
Not yet recruiting

Study of Hepatic Function in Patients With Spinal and Bulbar Muscular Atrophy

Conditions:   Spinal and Bulbar Muscular Atrophy;   Motor Neuron Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy

Condition:   Duchenne Muscular Dystrophy
Intervention:  
Sponsors:   University of Florida;   University of Pennsylvania;   Oregon Health and Science University;   Children's Hospital of Philadelphia;   Shriners Hospitals for Children;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Active, not recruiting

Disorder-tailored Transcranial Direct Current Stimulation (tDCS) of the Prefrontal Cortex

Conditions:   Major Depressive Disorder;   Schizophrenia
Intervention:   Device: Transcranial direct current stimulation (tDCS)
Sponsor:   Ludwig-Maximilians - University of Munich
Recruiting

Early Treatment of Post-stroke Spasticity With Botulinum Toxin

Condition:   Stroke
Intervention:   Other: Normal clinical practice
Sponsor:   Universita di Verona
Completed

Sodium-glucose Co Transporter 2 (sGLT2) Inhibitor and Endogenous Ketone Production

Conditions:   Empaglifozin;   Physiological Effects of Drugs;   Hypoglycemic Agents;   Sodium-Glucose Transporter 2 Inhibitors
Intervention:   Drug: Jardiance 25 mg
Sponsor:   National Institute on Aging (NIA)
Recruiting

The Early and Late Contribution of Fasting and Postprandial Triglycerides on Newborn Subcutaneous and Intrahepatic Fat in Pregnancy

Condition:   Pregnancy
Intervention:  
Sponsors:   University of Colorado, Denver;   American Diabetes Association
Not yet recruiting

Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes

Conditions:   Murmur, Heart;   Aortic Valve Stenosis;   Tricuspid Regurgitation;   Mitral Regurgitation;   Innocent Murmurs;   Heart Murmurs
Intervention:   Device: Use of Eko CORE and Eko DUO electronic stethoscopes
Sponsor:   Eko Devices, Inc.
Not yet recruiting

Bridging Thrombolysis Versus Direct Mechanical Thrombectomy in Acute Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Device: Stent-retriever thrombectomy with revascularization device of the Solitaire™ type;   Drug: Intravenous thrombolysis with recombinant tissue-type plasminogen activator (IV t-PA)
Sponsors:   University Hospital Inselspital, Berne;   Medtronic
Recruiting

The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

Conditions:   Mitral Annular Calcification;   Mitral Stenosis;   Mitral Regurgitation;   Mitral Valve Disease
Intervention:   Device: Transseptal ViMAC
Sponsor:   Mayra Guerrero
Not yet recruiting

Treatment of Brain AVMs (TOBAS) Study

Conditions:   Unruptured Brain Arteriovenous Malformation;   Ruptured Brain Arteriovenous Malformation;   Arteriovenous Malformations;   AVM;   BAVM
Interventions:   Procedure: Neurosurgery;   Radiation: Radiation therapy;   Procedure: Embolization
Sponsors:   Centre hospitalier de l'Université de Montréal (CHUM);   Centre Hospitalier Régional et Universitaire de Brest
Recruiting

Enhancing Community Participation for Stroke Survivors With Cognitive Impairments

Conditions:   Stroke;   Cognitive Impairment
Intervention:   Behavioral: Strategy Training
Sponsor:   Taipei Medical University
Recruiting

Endovascular Treatment in Ischemic Stroke Follow-up Evaluation

Condition:   Stroke, Acute
Intervention:  
Sponsor:   Hopital Foch
Recruiting

Structural Heart and Valve Network PROSPECTIVE Registry

Conditions:   Mitral Valve Regurgitation;   Heart Failure;   Heart Valve Disease;   Tricuspid Valve Regurgitation;   Aortic Valve Stenosis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

Endovascular Acute Stroke Intervention Trial - the EASI Trial

Condition:   Stroke, Acute
Interventions:   Procedure: mechanical thrombectomy;   Drug: Best standard treatment
Sponsor:   Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting

Uncovering Neural and Immune Mechanisms of Chronic Pain in Post Treatment Lyme Syndrome

Conditions:   Post Treatment Lyme Syndrome (PTLS);   Chronic Pain
Intervention:   Drug: Milnacipran and D-cycloserine
Sponsor:   New York State Psychiatric Institute
Terminated

Ketogenic Diet (KD) in Alcoholism

Condition:   Alcoholism
Intervention:   Other: 1. Ketogenic Diet (KD) / Standard American (SA) Meals and Sh
Sponsor:   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting

Intensive Care Associated Complications and Outcome of Acute Respiratory Distress Syndrome Due to COVID-19

Conditions:   COVID;   Corona Virus Infection;   Sars-CoV2
Intervention:   Procedure: Study Arm
Sponsor:   University Hospital Inselspital, Berne
Recruiting

Imaging Biomarkers in Parkinson s Disease

Condition:   Parkinson Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

A Study to Investigate the Effect of MEDI0382 on Hepatic Glycogen Metabolism in Overweight and Obese Subjects With Type 2 Diabetes Mellitus.

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: MEDI0382;   Drug: Placebo;   Drug: Liraglutide
Sponsor:   MedImmune LLC
Active, not recruiting

Brain Amyloid- Retention During Wakefulness and Following Emergence From Sleep in Healthy People

Condition:   Normal Physiology
Intervention:   Other: [18F]florbetaben
Sponsor:   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Completed

Cohort Study for Severe Ischaemic Stroke

Conditions:   Severe Ischaemic Stroke;   Malignant Ischaemic Stroke
Intervention:   Other: routine medical care
Sponsors:   West China Hospital;   Sichuan Academy of Medical Sciences &Sichuan Provincial People’s Hospital;   The Affiliated Hospital Of Southwest Medical University;   Affiliated Hospital of North Sichuan Medical College;   Chengdu University of Traditional Chinese Medicine;   Mianyang Central Hospital;   People’s Hospital of Deyang City;   The First People’s Hospital of Ziyang;   Jiangyou People’s Hospital;   Science & Technology Department of Sichuan Province;   National Natural Science Foundation of China
Active, not recruiting

SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease

Conditions:   Non-Alcoholic Fatty Liver Disease;   NAFLD;   Pediatric NAFLD
Interventions:   Drug: Empagliflozin 10 MG;   Drug: Placebo Oral Tablet
Sponsor:   University of Minnesota
Enrolling by invitation

Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System

Condition:   Healthy
Interventions:   Diagnostic Test: MRI;   Diagnostic Test: fMRI;   Diagnostic Test: MRS;   Diagnostic Test: MEG;   Diagnostic Test: EEG
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Skeletal Muscle Biomarkers in People With Fragile Sarcolemmal Muscular Dystrophy

Condition:   Genetic Disorder
Intervention:  
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institutes of Health Clinical Center (CC);   University of Massachusetts, Worcester
Active, not recruiting

Right Ventricular Metabolism in Pulmonary Arterial Hypertension

Conditions:   Pulmonary Arterial Hypertension;   Healthy
Intervention:  
Sponsor:   Vanderbilt University Medical Center
Completed

Mitral Implantation of TRAnscatheter vaLves

Condition:   Mitral Valve Disease
Intervention:   Device: Transcatheter Mitral Valve Replacement
Sponsors:   Mayra Guerrero;   Henry Ford Hospital
Active, not recruiting

18F-Fluciclovine PET and Multiparametric MR Imaging

Condition:   Brain Tumor, Recurrent, Adult
Intervention:   Drug: PET/CT with F-Fluciclovine (Axumin)
Sponsors:   Loma Linda University;   Blue Earth Diagnostics
Recruiting

Early Percutaneous Mitral Intervention in Asymptomatic Moderate Mitral Stenosis

Condition:   Moderate Mitral Stenosis
Intervention:   Procedure: Percutaneous Mitral Commissurotomy
Sponsor:   Asan Medical Center
Completed

Intracavitary Injection of hUMSCs in Acute Basal Ganglia Hematoma After Stereotactic Aspiration

Condition:   Basal Ganglia Hematoma
Interventions:   Procedure: stereotactic surgery;   Biological: hUMSCs;   Biological: placebo
Sponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   The First Affiliated Hospital, University of Science and Technology of China;   Huzhou Hospital, School of Medicine, Zhejiang University;   First Affiliated Hospital of Fujian Medical University;   Jinhua Hospital, School of Medicine, Zhejiang University;   Taizhou Hospital
Recruiting

EndoVascular Treatment of Acutely Ruptured Shallow Intradural Aneurysms Not Amenable To Clipping And coilinG With the Pipeline™ Vantage Embolization Device (VANTAGE)

Conditions:   Intracranial Aneurysm;   Ruptured Aneurysm
Intervention:   Device: Pipeline™ Vantage Embolization Device with Shield Technology™
Sponsor:   Medtronic Neurovascular Clinical Affairs
Not yet recruiting

Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome

Conditions:   Mitochondrial Disorders;   Li-Fraumeni Syndrome;   Carriers of p53 Mutation
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation

Reliability of the Human Brain Connectome

Condition:   Normal Physiology
Interventions:   Drug: F-18FDG;   Device: MRI
Sponsor:   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting

Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders

Conditions:   Mood Disorders;   Anxiety Disorders
Intervention:  
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting

FIrst-Pass Reperfusion With the NeVa Stent-Retriever Trial

Condition:   Acute Ischemic Stroke
Interventions:   Device: NeVa Stent Retrievers;   Device: Solitaire Stent Retrievers
Sponsor:   Vesalio
Withdrawn

The Role of Dysmyelination in Cognitive Impairment of Psychotic Spectrum Disorders

Conditions:   Schizophrenia;   Bipolar Disorder
Intervention:   Diagnostic Test: Cognitive Function Assessments
Sponsor:   NYU Langone Health
Active, not recruiting

Intranasal Ketamine With Dexmedetomidine for the Treatment of Children With Autism Spectrum Disorder

Condition:   Autism Spectrum Disorder
Interventions:   Drug: ketamine and dexmedetomidine;   Drug: ketamine;   Drug: Saline
Sponsor:   Guangzhou Women and Children's Medical Center
Recruiting

Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging

Conditions:   Drug Abuse;   Nicotine Dependence
Intervention:  
Sponsor:   National Institute on Drug Abuse (NIDA)
Recruiting

Based on the "Brain-gut -Lung" Axis, the Mechanism of Treating Stroke-associated Pneumonia by Tong-Fu-Xing-Shen Capsules

Conditions:   Stroke;   Complication
Interventions:   Drug: Tongfu capsules;   Drug: The Placebo of Tongfu capsules
Sponsors:   Guangzhou University of Traditional Chinese Medicine;   Ganzhou People's Hospital Affiliated to Nanchang University;   Lianjiang Hospital of Traditional Chinese Medicine;   Yangjiang Hospital of Traditional Chinese Medicine;   Liaoning Tumor Hospital & Institute
Recruiting

Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

Condition:   CAD
Interventions:   Device: MRI scan x 1 Healthy Volunteer;   Device: MRI scan x 2 Healthy Volunteer;   Device: MRI scan x 2 - CAD patients;   Device: MRI scan x 2- non CAD patients
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

A Study to Evaluate the Efficacy and Safety of BIIB093 in Participants With Brain Contusion

Condition:   Brain Contusion
Interventions:   Drug: BIIB093;   Drug: Placebo
Sponsor:   Biogen
Recruiting

The Carotid and Middle Cerebral Artery Occlusion Surgery Study

Conditions:   Carotid Artery Occlusion;   Middle Cerebral Artery Occlusion;   Stroke
Interventions:   Procedure: bypass surgery;   Drug: Aspirin;   Drug: Clopidogrel
Sponsor:   Xuanwu Hospital, Beijing
Active, not recruiting

Efficacy and Safety of IgPro10 in Adults With Systemic Sclerosis (SSc)

Condition:   Diffuse Cutaneous Systemic Sclerosis
Interventions:   Biological: IgPro10;   Biological: Placebo
Sponsor:   CSL Behring
Active, not recruiting

Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction

Condition:   Normal Physiology
Interventions:   Other: MRI;   Other: Neurometer CPT/C
Sponsor:   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting

Cardiac Arrest Incidence and Outcome Among Patients With COVID-19 in French ICUs

Conditions:   Sars-CoV2;   Covid-19
Interventions:   Other: Cardiopulmonary resuscitation;   Other: Modified Rankin score
Sponsor:   Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Recruiting

New Heart Imaging Techniques to Evaluate Possible Heart Disease

Conditions:   Healthy;   Obesity;   Diabetes;   Arteriosclerosis;   Healthy Volunteers
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Combined Use of Contact Aspiration and the Stent Retriever Technique Versus Stent Retriever Alone for Recanalisation in Acute Cerebral Infarction

Condition:   Acute Ischemic Stroke
Interventions:   Combination Product: Combined contact aspiration/Stent Retriever Technique;   Device: Stent retriever technique
Sponsor:   Hopital Foch
Completed

: Vascular Function in Health and Disease

Conditions:   Chronic Obstructive Pulmonary Disease;   Pulmonary Artery Hypertension;   Heart Failure;   Hypertension
Interventions:   Other: Maximum Exercise Tests;   Drug: BH4, L-NMMA, Vitamin C, Vitamin E, α-Lipoic Acid and L-Ascorbate;   Drug: BQ-123;   Drug: Fexofenadine, Ranitidine;   Other: Angiotensin-II, Valsartan;   Drug: Acetylcholine, Sodium Nitroprusside, Angiotensin-II, Norepinephrine, Phentolamine;   Drug: BQ-123, MitoQ, BH4
Sponsor:   Russell Richardson
Recruiting

Thrombectomy In TANdem Occlusion

Conditions:   Carotid Artery Diseases;   Thrombectomy;   Tandem Occlusion;   Stroke
Interventions:   Device: Carotid Stenting;   Drug: Procedural Aspirin;   Drug: Dual dual antiplatelet therapy after 24-hours imaging follow-up;   Procedure: Intracranial thrombectomy
Sponsor:   Central Hospital, Nancy, France
Recruiting

Transvenous Approach for the Treatment of Cerebral Arteriovenous Malformations

Conditions:   Arteriovenous Malformations, Cerebral;   Unruptured Brain Arteriovenous Malformation;   Ruptured Brain Arteriovenous Malformation
Interventions:   Procedure: Standard Trans-Arterial Embolization (TAE);   Procedure: Trans-Venous Embolization (TVE)
Sponsor:   Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting

HIRREM Hot Flashes Study

Conditions:   Vasomotor Symptoms;   Hot Flashes;   Menopause
Interventions:   Device: HIRREM;   Other: Continued Current Care
Sponsor:   Wake Forest University Health Sciences
Recruiting

CB-839 With Radiation Therapy and Temozolomide in Treating Participants With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma

Conditions:   Anaplastic Astrocytoma, IDH-Mutant;   Diffuse Astrocytoma, IDH-Mutant
Interventions:   Other: Questionnaire Administration;   Radiation: Radiation Therapy;   Drug: Telaglenastat Hydrochloride;   Drug: Temozolomide
Sponsor:   National Cancer Institute (NCI)
Recruiting

Effect of High Caloric Diet on Brain Insulin Sensitivity and Inflammation

Conditions:   Obesity;   Diabetes Mellitus, Type 2
Intervention:   Other: High caloric diet
Sponsor:   University Hospital Tuebingen
Completed

Primary Ovarian Insufficiency: Phenotype and Optimal Treatment

Condition:   Primary Ovarian Insufficiency
Intervention:   Drug: Transdermal Estrogen
Sponsors:   Children's Hospital Medical Center, Cincinnati;   Patty Brisben Foundation For Women's Sexual Health
Recruiting

Early Versus Late Initiation of Direct Oral Anticoagulants in Post-ischaemic Stroke Patients With Atrial fibrillatioN (ELAN): an International, Multicentre, Randomised-controlled, Two-arm, Assessor-blinded Trial

Condition:   Ischaemic Stroke
Interventions:   Drug: Early treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®);   Drug: Late treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®)
Sponsor:   University Hospital Inselspital, Berne
Recruiting

Inflammatory faCtors AfteR acUte Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Diagnostic Test: [18F]-GE-180 PET;   Diagnostic Test: 3T MRI;   Diagnostic Test: immune cell profiling in blood
Sponsors:   Martin Dichgans;   Universitätsklinikum Hamburg-Eppendorf;   University Hospital Muenster
Not yet recruiting

Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations

Conditions:   Advanced Malignant Solid Neoplasm;   Glioblastoma;   Recurrent Cholangiocarcinoma;   Recurrent Glioma;   Recurrent Malignant Solid Neoplasm;   WHO Grade II Glioma;   WHO Grade III Glioma
Intervention:   Drug: Olaparib
Sponsor:   National Cancer Institute (NCI)
Recruiting

IRIS Alfa Clinical Trial

Condition:   Vitrectomy
Intervention:   Device: IRIS
Sponsor:   Universitaire Ziekenhuizen Leuven
Not yet recruiting

Apnea, Stroke and Incident Cardiovascular Events

Conditions:   Stroke;   Sleep-disordered Breathing;   Sleep Apnea Syndromes;   Sleep Apnea, Obstructive;   Sleep Apnea, Central;   Fragmentation, Sleep
Intervention:   Device: Treatment according to standard care recommandation
Sponsor:   University Hospital, Grenoble
Not yet recruiting

Embolization of the Middle Meningeal Artery With ONYX™ Liquid Embolic System for Subacute and Chronic Subdural Hematoma

Condition:   Subdural Hematoma
Interventions:   Procedure: Surgical Management;   Device: Surgical Management + Treatment;   Other: No Treatment;   Device: Treatment
Sponsor:   Medtronic Neurovascular Clinical Affairs
Not yet recruiting

A Prospective Multicenter Study on Patients'Satisfaction With Angeliq® Micro in Real Clinical Practice Conducted in Russia

Condition:   Menopause
Intervention:   Drug: BAY86-4891
Sponsor:   Bayer
Active, not recruiting

Pipeline™ Vantage Embolization Device With Shield Technology™ for Wide-Necked Intracranial Aneurysms (ADVANCE)

Condition:   Intracranial Aneurysm
Intervention:   Device: Pipeline™ Vantage Embolization Device with Shield Technology™
Sponsor:   Medtronic Neurovascular Clinical Affairs
Recruiting

Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal and Pararenal Aortic Aneurysms

Condition:   Thoracoabdominal Aortic Aneurysm
Intervention:   Device: GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis
Sponsor:   W.L.Gore & Associates
Recruiting

Patient-Centered NeuroRehabilitation (PCN)

Condition:   Cognitive Deficit
Interventions:   Device: Active tDCS;   Device: Sham tDCS;   Behavioral: Cognitively based intervention;   Device: Active tACS;   Device: Sham tACS;   Device: Active tRNS;   Device: Sham tRNS
Sponsor:   University of Michigan
Suspended

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

Conditions:   Constitutional Mismatch Repair Deficiency Syndrome;   Lynch Syndrome;   Malignant Glioma;   Recurrent Brain Neoplasm;   Recurrent Childhood Ependymoma;   Recurrent Diffuse Intrinsic Pontine Glioma;   Recurrent Medulloblastoma;   Refractory Brain Neoplasm;   Refractory Diffuse Intrinsic Pontine Glioma;   Refractory Ependymoma;   Refractory Medulloblastoma
Interventions:   Procedure: Diffusion Tensor Imaging;   Procedure: Diffusion Weighted Imaging;   Procedure: Dynamic Contrast-Enhanced Magnetic Resonance Imaging;   Procedure: Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging;   Other: Laboratory Biomarker Analysis;   Procedure: Magnetic Resonance Spectroscopic Imaging;   Biological: Pembrolizumab;   Procedure: Perfusion Magnetic Resonance Imaging
Sponsor:   National Cancer Institute (NCI)
Recruiting