Mitral Valve Regurgitation

Clinical Trial Finder

Many patients with mitral valve regurgitation are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

A Trial of Maraviroc +/- Metformin for Hepatic Steatosis in Chronic HIV-1 Infection

Conditions:   Hepatic Steatosis;   HIV-1-infection
Interventions:   Drug: Maraviroc;   Drug: Metformin
Sponsor:   MRC [ycm]
Not yet recruiting - verified April 2017

PROphylactic triCuspID Annuloplasty in Patients With Dilated Tricuspid Annulus

Condition:   Tricuspid (Valve) Insufficiency (Rheumatic)
Interventions:   Procedure: Mitral valve surgery;   Procedure: Tricuspid valve annuloplasty
Sponsor:   Ettore Sansavini Health Science Foundation
Not yet recruiting - verified April 2017

Technique of Per-Operative Radiotherapy (RPO) by Papillon +TM in Localized Breast Cancer

Condition:   Localized Breast Cancer
Intervention:   Device: Papillon +TM
Sponsor:   Centre Antoine Lacassagne
Not yet recruiting - verified April 2017

High Intensity Focused Ultrasound Guided by MRI as Thermic Destruction in Primitive Small Size Breast Cancer

Condition:   Breast Cancer
Intervention:   Procedure: HIGH INTENSITY FOCUSED ULTRASOUND
Sponsor:   Centre Antoine Lacassagne
Not yet recruiting - verified April 2017

Study of Treatment of Unruptured Intracranial Aneurysms in China

Condition:   Un-ruptured Intracranial Aneurysm,Interventional Therapy,Craniotomy
Intervention:  
Sponsors:   Zhujiang Hospital;   Xuanwu hospital center image interpretation laboratory;   National center for cardiovascular disease, department of medical statistics
Not yet recruiting - verified April 2017

Managing Aftercare for Stroke (MAS): MAS-II - A Longitudinal Complex-interventional Study in Post-rehabilitation Stroke Patients

Condition:   Stroke
Intervention:   Other: comprehensive multidisciplinary stroke care
Sponsors:   Charite University, Berlin, Germany;   Center for Stroke Research Berlin;   Hebrew University of Jerusalem;   NeuroCure Clinical Research Center
Recruiting - verified April 2017

Effect of External Counter Pulsation on Ischemic Stroke

Condition:   Ischemic Stroke
Intervention:   Device: External counter pulsation (ECP)
Sponsors:   Eighth Affiliated Hospital, Sun Yat-sen University;   Shenzhen Research Institute, The Chinese University Hong Kong;   Second Affiliated Hospital of Xi'an Jiaotong University;   The Second Affiliated Hospital of Zhengzhou University
Not yet recruiting - verified April 2017

Molecular-Functional Imaging of Hypoxia in Childhood Sarcomas

Conditions:   Rhabdomyosarcoma;   Non-Rhabdo. Soft Tissue Sarcoma
Interventions:   Drug: 18F-FAZA (F18-Fluoroazomycin Arabinoside);   Diagnostic Test: Blood Oxygen Level Dependent [BOLD] MRI;   Diagnostic Test: Diffusion-Weighted [DW] MRI;   Diagnostic Test: Magnetic Resonance Spectroscopy [MRS]
Sponsor:   The Hospital for Sick Children
Enrolling by invitation - verified February 2017

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

Condition:   Mitral Valve Failure
Interventions:   Device: Edwards SAPIEN 3 transcatheter heart valve;   Device: ASHI INTECC Astato XS 20
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified January 3, 2017

Alkalinization by Urologists & Nephrologists

Conditions:   Metabolic Acidosis;   Nephrolithiasis;   Extracellular Alteration;   Blood Pressure;   Body Weight
Intervention:   Drug: Alkali
Sponsor:   Jean-Philippe Bertocchio
Recruiting - verified April 2017

NOACs for Stroke Prevention in Patients With Atrial Fibrillation and Previous ICH

Conditions:   Atrial Fibrillation;   Intracerebral Hemorrhage
Interventions:   Drug: NOAC;   Drug: Acetylsalicylic Acid
Sponsor:   Population Health Research Institute
Recruiting - verified April 2017

Effectiveness and Safety of SAR156597 in Treating Diffuse Systemic Sclerosis

Condition:   Systemic Sclerosis
Interventions:   Drug: SAR156597 (ACT14604);   Drug: Placebo
Sponsor:   Sanofi
Recruiting - verified April 2017

Effects of Riluzole on CNS Glutamate and Fatigue in Breast Cancer Survivors With High Inflammation

Conditions:   Inflammation;   Fatigue
Interventions:   Drug: Riluzole;   Drug: Placebo
Sponsor:   Emory University
Recruiting - verified April 2017

Neuroform Atlas Stent for Intracranial Aneurysm Treatment

Condition:   Intracranial Aneurysm
Intervention:  
Sponsor:   Stryker Neurovascular
Recruiting - verified April 2017

Edwards Lifesciences CardiAQ™ Transcatheter Mitral Valve Replacement (TMVR) Early Feasibility Study

Condition:   Mitral Valve Regurgitation (Degenerative or Functional)
Intervention:   Device: Transcatheter Mitral Valve Replacement (TMVR)
Sponsor:   Edwards Lifesciences
Recruiting - verified April 2017

Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3

Conditions:   Stroke, Acute;   Cerebral Infarction
Interventions:   Procedure: Endovascular Thrombectomy;   Device: Trevo Retriever;   Device: Solitaire™ FR Revascularization Device;   Device: Penumbra thrombectomy system;   Device: Covidien MindFrame Capture Revascularization Device
Sponsors:   Gregory W Albers;   National Institute of Neurological Disorders and Stroke (NINDS);   University of Cincinnati;   Medical University of South Carolina;   NINDS Stroke Trials Network (StrokeNet)
Recruiting - verified April 2017

A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis

Condition:   Scleroderma, Systemic
Interventions:   Drug: Nintedanib;   Drug: Placebo
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2017

Intermittent Calorie Restriction, Insulin Resistance, and Biomarkers of Brain Function

Conditions:   Alzheimer's Disease;   Obesity;   Diabetes Mellitus
Interventions:   Dietary Supplement: Boost A;   Behavioral: Healthy Living Diet
Sponsor:   National Institute on Aging (NIA)
Recruiting - verified February 8, 2017

Using Telmisartan With ART During Acute HIV Infection to Reduce the CNS Reservoirs of HIV and Lymph Node Fibrosis

Conditions:   Acute HIV Infection;   HIV CNS Involvement
Interventions:   Drug: TDF/3TC/EFV + Telmisartan;   Drug: TDF/3TC/EFV only
Sponsors:   South East Asia Research Collaboration with Hawaii;   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified April 2017

Study of Modified Stem Cells (SB623) in Patients With Chronic Motor Deficit From Ischemic Stroke

Condition:   Chronic Ischemic Stroke
Interventions:   Biological: SB623 Implant (2.5M);   Biological: SB623 Implant (5.0M);   Procedure: Sham surgery
Sponsors:   SanBio, Inc.;   Sunovion
Recruiting - verified February 2017

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, or Hypermutated Brain Tumors

Conditions:   Diffuse Intrinsic Pontine Glioma;   Lynch Syndrome;   Malignant Glioma;   Mismatch Repair Gene Inactivation;   Recurrent Childhood Brain Neoplasm;   Refractory Brain Neoplasm
Interventions:   Procedure: Diffusion Tensor Imaging;   Procedure: Diffusion Weighted Imaging;   Procedure: Dynamic Contrast-Enhanced Magnetic Resonance Imaging;   Procedure: Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging;   Other: Laboratory Biomarker Analysis;   Procedure: Magnetic Resonance Spectroscopic Imaging;   Biological: Pembrolizumab;   Procedure: Perfusion Magnetic Resonance Imaging
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified March 2017

Repetitive Transcranial Magnetic Stimulation Equipment Testing and Pilot Study

Condition:   Healthy Volunteer
Intervention:   Device: TMS
Sponsor:   National Institute on Drug Abuse (NIDA)
Recruiting - verified April 3, 2017

Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma

Conditions:   Malignant Glioma;   Refractory Brain Neoplasm;   Recurrent Brain Neoplasm;   Glioblastoma
Interventions:   Biological: IL13Rα2-specific, hinge-optimized, 41BB-costimulatory CAR/truncated CD19-expressing Autologous T lymphocytes;   Other: laboratory biomarker analysis;   Other: quality-of-life assessment;   Procedure: Magnetic Resonance Imaging;   Procedure: Magnetic Resonance Spectroscopic Imaging;   Biological: IL13Rα2-specific, hinge-optimized, 41BB-costimulatory CAR/truncated CD19-expressing Autologous T lymphocytes
Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI)
Recruiting - verified April 2017

Clinical Biomarkers in Alpha-mannosidosis

Condition:   Alpha-Mannosidosis
Intervention:  
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified February 17, 2017

The Neurophysiological Effects of Intravenous Alcohol as Potential Biomarkers of Ketamine's Rapid Antidepressant Effects in Major Depressive Disorder

Conditions:   Magnetic Resonance Imaging;   Major Depression;   Alcoholism
Interventions:   Drug: Ketamine;   Other: Alcohol Infusion
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting - verified November 22, 2016

PERIGON Pivotal Trial

Condition:   Aortic Stenosis
Intervention:   Device: Model 400 aortic valve bioprosthesis
Sponsors:   Medtronic Cardiovascular;   Medtronic
Recruiting - verified April 2017

High-field Brain Magnetic Resonance Spectroscopy

Condition:   Healthy
Intervention:  
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Active, not recruiting - verified April 2017

Study to Determine if Enhancing Glutamate Transporter Function Produces Antidepressant Effects in People With Major Depressive Disorder

Condition:   Depression
Interventions:   Drug: Diazoxide;   Drug: Placebo
Sponsor:   National Institute of Mental Health (NIMH)
Terminated - verified July 21, 2016

A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome

Condition:   Li-Fraumeni Syndrome
Intervention:   Drug: Metformin
Sponsor:   National Cancer Institute (NCI)
Completed - verified April 21, 2017

Functional Brain Imaging in Healthy Volunteers to Study Cognitive Functions

Condition:   Healthy Volunteers
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 11, 2016

Testosterone Replacement in Non-alcoholic Steatohepatitis (TEREPINS)

Conditions:   Nonalcoholic Steatohepatitis;   Hypogonadism
Intervention:   Drug: testosterone undecanoate
Sponsors:   Sheffield Teaching Hospitals NHS Foundation Trust;   Bayer
Completed - verified April 2017

THE IMPACT- 24Bt Post rtPA TRIAL (IMPlant Augmenting Cerebral Blood Flow Trial 24 Hours From Stroke Onset, Post IV-rtPA)

Condition:   Ischemic Stroke
Interventions:   Device: The Ischemic Stroke System;   Device: Sham control
Sponsor:   BrainsGate
Recruiting - verified April 2017

Skeletal Muscle Biomarkers in People With Fragile Sarcolemmal Muscular Dystrophy

Condition:   Genetic Disorder
Intervention:  
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institutes of Health Clinical Center (CC);   University of Massachusetts, Worcester
Recruiting - verified March 22, 2017

Early and Longitudinal Assessment of Neurodegeneration in the Brain and Spinal Cord in Friedreich's Ataxia

Condition:   Friedreich Ataxia
Intervention:  
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Bob Allison Ataxia Research Center;   Friedreich's Ataxia Research Alliance
Enrolling by invitation - verified April 2017

Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders

Conditions:   Schizo-affective Disorder;   Bipolar Disorder
Interventions:   Drug: Glycine;   Drug: placebo
Sponsors:   Mclean Hospital;   National Institute of Mental Health (NIMH)
Active, not recruiting - verified April 2017

The STem Cell Application Researches and Trials In NeuroloGy-2 (STARTING-2) Study

Condition:   Stroke, Ischemic
Intervention:   Other: Mesenchymal stem cell
Sponsors:   Samsung Medical Center;   Pharmicell Co., Ltd.
Recruiting - verified April 2017

Safety & Efficacy Study of the Medtronic CoreValve® System-Treatment of Symptomatic Severe Aortic Stenosis With Significant Comorbidities in Extreme Risk Subjects Who Need Aortic Valve Replacement

Condition:   Severe Aortic Stenosis
Intervention:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting - verified April 2017

Nicotine Withdrawal Symptoms and Smoking Relapse

Condition:   Nicotine Dependence
Intervention:  
Sponsor:   National Institute on Drug Abuse (NIDA)
Recruiting - verified April 3, 2017

Measuring Effects of Alcohol on Brain Chemistry

Condition:   Healthy Volunteers
Intervention:  
Sponsor:   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Terminated - verified February 24, 2015

Metformin in Obese Children and Adolescents

Conditions:   Obesity;   Insulin Resistance
Interventions:   Drug: Metformin;   Behavioral: Lifestyle intervention
Sponsors:   St. Antonius Hospital;   Jeroen Bosch Ziekenhuis
Completed - verified April 2017

Effect of Ischemic Strokes on Recovery From Intracerebral Hemorrhages

Conditions:   Hemorrhage; Intracerebral, Nontraumatic;   Ischemic Strokes;   Diffusion Weighted Imaging Lesions
Intervention:  
Sponsors:   Rush University Medical Center;   American Heart Association;   Rush University
Recruiting - verified April 2017

Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle

Conditions:   Brain Mapping;   Healthy Volunteer
Intervention:  
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting - verified February 27, 2017

A Pilot Clinical Trial of Exendin-4 in Alzheimer's Disease

Conditions:   Alzheimer's Disease;   Mild Cognitive Impairment
Intervention:   Drug: Exendin-4 (Exenatide)
Sponsor:   National Institute on Aging (NIA)
Completed - verified February 27, 2017

EASE MITRAL Expertise-based Assessment Study on Clinical Efficacy of Profile 3D in MITRAL Valve Annuloplasty

Condition:   Mitral Valve Insufficiency
Intervention:  
Sponsor:   Medtronic Bakken Research Center
Active, not recruiting - verified April 2017

Cardiovascular Radiologic and Metabolic Assessment in HIV: An Investigation of Pathophysiology

Conditions:   HIV;   Cardiovascular Disease
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Completed - verified August 7, 2015

New Techniques to Evaluate Mitral Regurgitation

Condition:   Mitral Valve Regurgitation
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified June 13, 2016

A Magnetic Resonance Spectroscopic Examination of Children and Adolescents Taking Riluzole for Obsessive-Compulsive Disorder

Conditions:   Childhood Obsessive-Compulsive Disorder;   Autism Spectrum Disorders
Intervention:  
Sponsor:   National Institute of Mental Health (NIMH)
Terminated - verified September 20, 2012

GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Depression;   Depressive Disorder, Major
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 2, 2013

Effect of Reward on Learning in Motor Cortex

Condition:   Healthy
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   United States Department of Defense;   National Institutes of Health Clinical Center (CC);   Center for Neuroscience and Regenerative Medicine (CNRM)
Completed - verified January 22, 2013

Implant for Augmentation of Cerebral Blood Flow Trial, Effectiveness and Safety in a 24 Hour Window

Condition:   Ischemic Stroke
Interventions:   Device: The Ischemic Stroke System;   Device: Sham control
Sponsor:   BrainsGate
Recruiting - verified April 2017

Non-Invasive Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy Techniques (MRS) for Assessing Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer

Condition:   Breast Cancer
Interventions:   Procedure: Magnetic Resonance Imaging (MRI);   Procedure: Magnetic Resonance Spectroscopy (MRS)
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Active, not recruiting - verified April 2017

Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome

Condition:   Li-Fraumeni Syndrome
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 4, 2017

The Role of Cytokine-Serotonin Interactions in Post-Stroke Depression

Condition:   Depression
Intervention:   Drug: Citalopram
Sponsor:   Sunnybrook Health Sciences Centre
Completed - verified April 2017

Phase I Study of Intensity Modulated Radiation Therapy for Prostate Cancer

Condition:   Prostate Cancer
Intervention:   Radiation: Radiation
Sponsor:   National Cancer Institute (NCI)
Completed - verified September 26, 2016

MRS Measurement of Glutamate and GABA Metabolism in Brain

Condition:   Healthy
Intervention:   Procedure: Magnetic Resonance Spectroscopy
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting - verified June 30, 2016

Central Nervous System Disease in HIV-infected Children on HAART

Conditions:   HIV Infections;   Central Nervous System Diseases
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Completed - verified September 9, 2014

Comparison of PET and Proton MRS Imaging to Evaluate Pediatric Brain Tumor Activity

Condition:   Brain Tumors
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified September 23, 2016

Magnetic Resonance Spectroscopy to Evaluate Tourette s Syndrome

Condition:   Tourette Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified February 3, 2015

Comparing Magnetic Resonance Imaging/Spectroscopy Techniques

Condition:   MRI Scans
Intervention:  
Sponsor:   National Institutes of Health Clinical Center (CC)
Enrolling by invitation - verified April 10, 2017

Study of New Magnetic Resonance Methods

Condition:   Healthy
Intervention:  
Sponsor:   National Institutes of Health Clinical Center (CC)
Terminated - verified September 7, 2012