Mitral Valve Regurgitation

Clinical Trial Finder

Many patients with mitral valve regurgitation are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Non-invasive Clinical Imaging of Cerebral Metabolism Following Brain Injury Using 13C Magnetic Resonance Spectroscopy.

Condition:   Traumatic Brain Injury
Intervention:   Device: magnetic resoance imaging
Sponsor:   Loma Linda University
Enrolling by invitation - verified April 2016

Abituzumab in SSc-ILD

Condition:   Systemic Sclerosis-associated Interstitial Lung Disease (SSc-ILD)
Interventions:   Drug: Abituzumab 1500 mg;   Drug: Abituzumab 500 mg;   Drug: Placebo
Sponsors:   EMD Serono Research & Development Institute, Inc.;   Merck KGaA
Not yet recruiting - verified April 2016

An fMRI Study of the Efficacy and Safety of Jianpi Yishen Huatan Granules for Cognitive Impairment After Acute Cerebral Infarction

Condition:   Cognitive Impairment
Interventions:   Drug: Jianpi Yishen Huatan Granules;   Other: basic treatment
Sponsor:   Dongfang Hospital Affiliated to Beijing University of Chinese Medicine
Recruiting - verified April 2016

Development and Validation of Multi-nuclear Magnetic Resonance Imaging and Spectroscopy for Whole Body Human Applications

Conditions:   Human Body Composition;   Human Body Function
Intervention:   Other: To evaluate the reproducibility of acquiring multi-nuclear data on a new 3T Philips Magnet
Sponsor:   Translational Research Institute for Metabolism and Diabetes, Florida
Recruiting - verified April 2016

Magnetic Seizure Therapy for Schizophrenia

Condition:   Schizophrenia
Interventions:   Procedure: magnetic seizure therapy;   Procedure: electroconvulsive therapy
Sponsor:   Shanghai Mental Health Center
Recruiting - verified April 2016

The Impact of NBP on the Collateral Circulation in ICA/M1 Occlusion

Conditions:   Cerebrovascular Occlusion;   Collateral Blood Circulation;   Anterior Cerebral Circulation Infarction
Intervention:   Drug: NBP
Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University
Enrolling by invitation - verified April 2016

A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis

Condition:   Scleroderma, Systemic
Interventions:   Drug: Nintedanib;   Drug: Placebo
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2016

Magnetic Resonance Spectroscopy (MRS) in Midlife Depression

Conditions:   Depression;   Depression Bipolar
Sponsor:   Emory University
Not yet recruiting - verified April 2016

High and Intermediate Risk Degenerative Mitral Regurgitation Treatment: A Trial Comparing MitraClip® to Surgical Therapy

Condition:   Mitral Valve Insufficiency
Interventions:   Device: MitraClip®;   Procedure: Mitral valve Surgery
Sponsor:   University of Zurich
Recruiting - verified April 2016

NAFLD in Adolescents and Young Adults With PCOS

Conditions:   Polycystic Ovary Syndrome;   Non-Alcoholic Fatty Liver Disease;   Metabolic Syndrome
Sponsor:   Columbia University
Recruiting - verified April 2016

Prospective Record Of the Use of Dabigatran in Patients With Acute Stroke or TIA

Conditions:   Brain Ischemia With Non-valvular Atrial Fibrillation;   Transient Ischemic Attack With Non-valvular Atrial Fibrillation
Sponsor:   University Hospital, Essen
Recruiting - verified April 2016

Metformin for Ectopic Fat Deposition and Metabolic Markers in Polycystic Ovary Syndrome (PCOS)

Conditions:   Polycystic Ovary Syndrome;   Non-Alcoholic Fatty Liver Disease;   Metabolic Syndrome
Interventions:   Drug: Metformin;   Drug: Placebo
Sponsor:   Columbia University
Recruiting - verified April 2016

Assessment of the HIV CNS Reservoir, Neurological and Neuro-cognitive Effects, and Source of Rebound HIV in CNS

Conditions:   Acute HIV Infection;   HIV CNS Involvement
Sponsors:   South East Asia Research Collaboration with Hawaii;   US NIH Research Project Grant Program
Completed - verified March 2016

Using Telmisartan With ART During Acute HIV Infection to Reduce the CNS Reservoirs of HIV and Lymph Node Fibrosis

Conditions:   Acute HIV Infection;   HIV CNS Involvement
Interventions:   Drug: TDF/3TC/EFV + Telmisartan;   Drug: TDF/3TC/EFV only
Sponsors:   South East Asia Research Collaboration with Hawaii;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2016

The Safety and Efficacy Study of High Dose Atorvastatin After Thrombolytic Treatment in Acute Ischemic Stroke

Condition:   Stroke
Intervention:   Device: atorvastatin
Sponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   First Hospital of Jilin University
Recruiting - verified April 2016

Study of Modified Stem Cells (SB623) in Patients With Chronic Motor Deficit From Ischemic Stroke

Condition:   Chronic Ischemic Stroke
Interventions:   Biological: SB623 Implant (2.5M);   Biological: SB623 Implant (5.0M);   Procedure: Sham surgery
Sponsors:   SanBio, Inc.;   Sunovion
Recruiting - verified April 2016

Study of Compound Edaravone Injection for Treatment of Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke
Interventions:   Drug: Compound Edaravone Injection;   Drug: Edaravone Injection
Sponsor:   Jiangsu Simcere Pharmaceutical Co., Ltd.
Active, not recruiting - verified April 2016

BestFIT: a Personalized Weight Loss Program

Condition:   Obesity
Interventions:   Behavioral: Behavioral weight loss therapy;   Behavioral: Meal replacements;   Behavioral: Enhanced behavioral weight loss therapy
Sponsors:   HealthPartners Institute;   Drexel University;   University of Michigan;   University of Minnesota - Clinical and Translational Science Institute;   University of Washington
Recruiting - verified December 2015

Exercise Intervention to Prevent Gestational Diabetes

Condition:   Gestational Diabetes Mellitus
Intervention:   Behavioral: Stationary bike
Sponsor:   Peking University First Hospital
Active, not recruiting - verified April 2016

Measuring of Neuro-visual Functionality With Ocusweep

Condition:   Visual Impairment
Intervention:   Device: Ocusweep
Sponsor:   Ocuspecto Oy
Recruiting - verified April 2016

Glutamate Probes in Adolescent Depression

Conditions:   Major Depressive Disorder;   Major Depressive Disorder, Recurrent;   Major Depressive Disorder, Remitted
Sponsor:   Mayo Clinic
Recruiting - verified April 2016

Ledipasvir/Sofosbuvir Fixed-Dose Combination on Cerebral Metabolism and Neurocognition in Treatment-Naive and Treatment-Experienced Participants With Chronic Genotype 1 HCV Infection

Condition:   Hepatitis C Virus Infection
Interventions:   Drug: LDV/SOF;   Drug: Placebo to match LDV/SOF
Sponsor:   Gilead Sciences
Completed - verified April 2016

Neuroprotection of Pioglitazone in Acute Ischemic Stroke

Condition:   Stroke
Interventions:   Drug: Pioglitazone;   Drug: Placebo
Sponsor:   Taipei Medical University Shuang Ho Hospital
Recruiting - verified April 2016

Role of DbXell in the Treatment of Subjects With Mildly Uncontrolled Type 2 Diabetes Mellitus

Condition:   Type 2 Diabetes Mellitus
Interventions:   Dietary Supplement: DbXell;   Dietary Supplement: Placebo
Sponsors:   Laniado Hospital;   K.G.S Research & Entrepreneurship, Israel
Recruiting - verified April 2016

Finding the Optimal Cooling tempeRature After Out-of-HoSpiTal Cardiac Arrest

Condition:   Out-Of-Hospital Cardiac Arrest.
Interventions:   Device: Target Temperature Management of 34°C;   Device: Target Temperature Management of 32°C;   Device: Target Temperature Management of 33°C
Sponsors:   ZOLL Circulation, Inc., USA;   Instituto de Investigación Hospital Universitario La Paz
Completed - verified April 2016

Preoperative Staging and Dose Escalated Radiotherapy of Prostate Carcinoma With PET and MRI

Condition:   Prostate Carcinoma
Intervention:   Device: PET/CT, PET/MRI, mpMRI
Sponsors:   Turku University Hospital;   GE Healthcare
Active, not recruiting - verified April 2016

Advanced Neuroimaging Evaluation of the Central Nervous System Biological Changes Associated With Efavirenz Therapy Switch to an Raltegravir-based Regimen

Conditions:   HIV;   HIV-associated Neurocognitive Disorder;   Neurotoxicity
Intervention:   Drug: switch efavirenz (EFV) to raltegravir (RAL)
Sponsors:   Massachusetts General Hospital;   Merck Sharp & Dohme Corp.
Active, not recruiting - verified April 2016

Cortical Excitability and Inhibition in MDD

Conditions:   Major Depressive Disorder, Recurrent, Mild;   Depressive Disorder, Major
Interventions:   Device: Transcranial Magnetic Stimulation (TMS);   Device: Magnetic Resonance Spectroscopy and Imaging
Sponsor:   Mayo Clinic
Active, not recruiting - verified April 2016

Safety & Efficacy Study of the Medtronic CoreValve® System-Treatment of Symptomatic Severe Aortic Stenosis With Significant Comorbidities in Very High Risk Subjects Who Need Aortic Valve Replacement

Condition:   Severe Aortic Stenosis
Intervention:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting - verified April 2016

Pilot Study Effect of Sulfasalazine on Glutamate Levels by(Magnetic Resonance Spectroscopy)MRS in Patients With Glioma

Condition:   Brain Tumor
Intervention:   Drug: Sulfasalazine
Sponsor:   University of Alabama at Birmingham
Completed - verified April 2016

Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial

Conditions:   Acute Ischemic Stroke;   Diabetes;   Hyperglycemia
Interventions:   Drug: IV insulin to maintain target glucose concentration of 80-130 mg/dL;   Drug: Standard Care control - sliding scale insulin to keep glucose less than 180 mg/dL
Sponsors:   University of Virginia;   Neurological Emergencies Treatment Trials Network (NETT);   Medical University of South Carolina;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 2014

Non-Invasive Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy Techniques (MRS) for Assessing Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer

Condition:   Breast Cancer
Interventions:   Procedure: Magnetic Resonance Imaging (MRI);   Procedure: Magnetic Resonance Spectroscopy (MRS)
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Active, not recruiting - verified April 2016

Genotype - Phenotype Correlations of LINCL

Conditions:   Batten Disease;   Late Infantile Neuronal Lipofuscinosis
Sponsors:   Weill Medical College of Cornell University;   Nathan's Battle Foundation
Completed - verified April 2016

Study of New Magnetic Resonance Methods

Condition:   Healthy
Sponsor:   National Institutes of Health Clinical Center (CC)
Terminated - verified September 2012

Comparing Magnetic Resonance Imaging/Spectroscopy Techniques

Condition:   MRI Scans
Sponsor:   National Institutes of Health Clinical Center (CC)
Recruiting - verified May 2015