Mitral Valve Regurgitation

Clinical Trial Finder

Many patients with mitral valve regurgitation are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Predicting Treatment Response to Memantine in Autism Using Magnetic Resonance Spectroscopy

Condition:   Autism Spectrum Disorder
Interventions:   Drug: Memantine;   Device: Magnetic Resonance Imaging
Sponsor:   University of Missouri-Columbia
Recruiting - verified June 2016

Inositol for Comorbid Anxiety in Children and Adolescents With Bipolar Disorder

Conditions:   Bipolar Disorder;   Anxiety Disorders;   Anxiety
Intervention:   Drug: Inositol
Sponsor:   University of Pittsburgh
Not yet recruiting - verified June 2016

Smart Nitinol Stent System for the Treatment of Severe Atherosclerotic Carotid Stenosis

Condition:   Carotid Artery Stenosis
Interventions:   Device: Smart nitinol stent implantation;   Drug: antiplatelet drug
Sponsor:   Beijing Jishuitan Hospital
Completed - verified June 2016

A Reduction in Time With Electronic Monitoring In Stroke Trial

Conditions:   Acute Ischemic Stroke;   Stroke
Intervention:   Other: real-time visual feedback
Sponsors:   Leiden University Medical Center;   The Dutch Brain Foundation;   Innovation Fund Healthcare Insurers, the Netherlands
Not yet recruiting - verified June 2016

A Study Comparing the Effect of Albiglutide With Exenatide on Regional Brain Activity Related to Nausea in Healthy Subjects

Condition:   Diabetes Mellitus
Interventions:   Drug: Albiglutide 50mg;   Drug: Albiglutide matching placebo;   Drug: Exenatide 10microgram;   Drug: Exenatide placebo (saline)
Sponsors:   GlaxoSmithKline;   The General Hospital Corporation d/b/a Massachusetts General Hospital
Not yet recruiting - verified June 2016

Safety and Efficacy of a Device for Degenerative Mitral Valve Repair

Condition:   Mitral Valve Insufficiency
Interventions:   Device: NeoChord DS1000;   Device: Surgical Mitral Valve Repair
Sponsor:   NeoChord
Not yet recruiting - verified June 2016

Impact of Remote Ischemic Postconditioning on Autonomic Function in Stroke Patients

Condition:   Ischemic Stroke
Interventions:   Procedure: remote ischemic postconditioning;   Procedure: sham remote ischemic postconditioning
Sponsor:   Guangzhou University of Traditional Chinese Medicine
Recruiting - verified June 2016

Safety and Efficacy of Intravenous Natalizumab in Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke
Interventions:   Drug: natalizumab;   Drug: Placebo
Sponsor:   Biogen
Recruiting - verified June 2016

Basilar Artery Occlusion Chinese Endovascular Trial

Conditions:   Basilar Artery Occlusion;   Ischemic Stroke;   Cerebrovascular Disorders
Interventions:   Procedure: Mechanical embolectomy;   Drug: Medical Treatment
Sponsors:   Xuanwu Hospital, Beijing;   Zhangzhou Municipal Hospital of Fujian Province;   The First People's Hospital of Changzhou;   Xinqiao Hospital of Chongqing;   Changhai Hospital;   Baotou Central Hospital;   The 101st Hospital of Chinese People's Liberation Army;   Linyi People's Hospital;   Zhongshan People's Hospital, Guangdong, China;   PLA 264 Hospital, Taiyuan, Shanxi;   Nanjing First People's Hospital;   Tianjin TEDA Hospital;   The First Affiliated Hospital with Nanjing Medical University;   Liaocheng Third People's Hospital;   Luoyang Central Hospital Affiliated to Zhengzhou University;   Subei People's Hospital of Jiangsu Province;   PLA 148 Hospital, Zibo, Shandong;   Hebei General Hospital;   Shengli Oilfield Hospital;   The 306 Hospital of People's Liberation Army;   Shenzhen Bao'an District People's Hospital;   First Hospital of Jilin University;   Henan Provincial Hospital;   Peking University Binhai Hospital;   Beijing Tiantan Hospital;   The Military General Hospital of Beijing, PLA;   The First Affiliated Hospital of Shanxi Medical University;   The Second Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine;   Beijing Luhe Hospital;   Nantong University;   The Affiliated Hospital Of Guizhou Medical University;   Nanning Second People's Hospital;   Chongqing Three Gorges Central Hospital
Not yet recruiting - verified June 2016

Safety and Performance of the Accucinch System

Conditions:   Heart Failure;   Mitral Valve Insufficiency
Intervention:   Device: Accucinch Implant
Sponsor:   Guided Delivery Systems Inc.
Not yet recruiting - verified June 2016

GLP-1 and Hyperoxia for Organ Protection in Heart Surgery

Conditions:   Coronary Disease;   Shock, Cardiogenic;   Renal Failure;   Stroke;   Brain Injury;   Aortic Valve Disease
Interventions:   Drug: Byetta (Lilly, Exenatide);   Drug: Conoxia (AGA, oxygen);   Drug: 20% Human Albumin
Sponsor:   Rigshospitalet, Denmark
Recruiting - verified June 2016

AMENDTM Mitral Valve Repair System, Annuloplasty Ring Applied in a Transcatheter Method

Condition:   Mitral Regurgitation
Intervention:   Device: AMEND Mitral Valve Repair System
Sponsor:   Valcare Medical Ltd.
Recruiting - verified June 2016

Assessing the Impact of Different Compression of the Hand Versus Free Hand on the Implementation of the Precision Grip

Condition:   Burned Hands
Interventions:   Device: made to measure compression gloves;   Device: Compression bandaging;   Other: Free Hands
Sponsor:   Hôpital Léon Bérard
Recruiting - verified January 2016

Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3

Conditions:   Stroke, Acute;   Cerebral Infarction
Interventions:   Procedure: Endovascular Thrombectomy;   Device: Trevo Retriever;   Device: Solitaire™ FR Revascularization Device;   Device: Penumbra thrombectomy system;   Device: Covidien MindFrame Capture Revascularization Device
Sponsors:   Gregory W Albers;   National Institute of Neurological Disorders and Stroke (NINDS);   University of Cincinnati;   Medical University of South Carolina;   NINDS Stroke Trials Network (StrokeNet)
Recruiting - verified June 2016

Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of DS-1040b in Subjects With Acute Ischemic Stroke

Conditions:   Acute Ischemic Stroke;   Thrombotic Disease
Interventions:   Drug: DS-1040b;   Drug: placebo
Sponsor:   Daiichi Sankyo Inc.
Recruiting - verified June 2016

A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis

Condition:   Scleroderma, Systemic
Interventions:   Drug: Nintedanib;   Drug: Placebo
Sponsor:   Boehringer Ingelheim
Recruiting - verified June 2016

Magnetic Resonance Spectroscopy (MRS) in Midlife Depression

Conditions:   Depression;   Depression Bipolar
Sponsor:   Emory University
Not yet recruiting - verified June 2016

Proof-of-concept Trial of IVA337 in Diffuse Cutaneous Systemic Sclerosis

Conditions:   Scleroderma, Diffuse;   Diffuse Cutaneous Systemic Sclerosis
Interventions:   Drug: IVA337;   Drug: Placebo
Sponsor:   Inventiva Pharma
Recruiting - verified June 2016

Study of Modified Stem Cells (SB623) in Patients With Chronic Motor Deficit From Ischemic Stroke

Condition:   Chronic Ischemic Stroke
Interventions:   Biological: SB623 Implant (2.5M);   Biological: SB623 Implant (5.0M);   Procedure: Sham surgery
Sponsors:   SanBio, Inc.;   Sunovion
Recruiting - verified June 2016

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas or Diffuse Intrinsic Pontine Gliomas

Conditions:   Diffuse Intrinsic Pontine Glioma;   Malignant Glioma;   Recurrent Childhood Brain Neoplasm
Interventions:   Procedure: Diffusion Tensor Imaging;   Procedure: Diffusion Weighted Imaging;   Procedure: Dynamic Contrast-Enhanced Magnetic Resonance Imaging;   Procedure: Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging;   Other: Laboratory Biomarker Analysis;   Procedure: Magnetic Resonance Spectroscopic Imaging;   Biological: Pembrolizumab;   Procedure: Perfusion Magnetic Resonance Imaging
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified May 2016

Physiological Effects of Nutritional Support in Patients With Parkinson's Disease

Conditions:   Parkinson Disease;   Idiopathic Parkinson Disease
Intervention:   Dietary Supplement: Intravenous and Oral n—acetyl cysteine
Sponsor:   Thomas Jefferson University
Recruiting - verified June 2016

Sedation Depth in Neurocritical Care

Condition:   Sedation of Cerebrovascular Ventilated Critical Care Patients
Interventions:   Other: Intensive Care Sedation (depth, level);   Drug: Vasopressors to maintain normal blood pressure values, if needed;   Drug: Osmotherapeutics to lowr intracranial pressure, if needed;   Procedure: Endovascular stroke care to treat brain vessel occlusions, if needed;   Procedure: Decompressive neurosurgery, if needed
Sponsor:   Heidelberg University
Not yet recruiting - verified June 2016

Acupuncture for Cerebral Vasospasm After Subarachnoid Hemorrhage

Conditions:   SAH (Subarachnoid Hemorrhage);   Cerebral Vasospasm
Interventions:   Device: acupuncture;   Device: Electroacupuncture;   Device: Intradermal acupuncture;   Device: Mock transcutaneous electrical nerve stimulation;   Device: sham intradermal acupuncture
Sponsor:   Kyung Hee University Hospital at Gangdong
Recruiting - verified June 2016

Glutamate-Glutamine Cycling (VCYC) During Cocaine Abstinence Using 13C-MRS

Condition:   Cocaine Dependence
Interventions:   Drug: N-acetyl cysteine;   Drug: riluzole;   Drug: pentoxifylline;   Drug: 13C MRS;   Behavioral: Continued abstinence
Sponsor:   Yale University
Recruiting - verified June 2016

PERIGON Pivotal Trial

Condition:   Aortic Stenosis
Intervention:   Device: Model 400 aortic valve bioprosthesis
Sponsors:   Medtronic Cardiovascular;   Medtronic
Recruiting - verified June 2016

Phase ⅡStudy of Pinocembrin Injection to Treat Ischemic Stroke

Condition:   Ischemic Stroke
Intervention:   Drug: Pinocembrin for Injection
Sponsor:   CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Suspended - verified October 2015

Functional Brain Imaging in Healthy Volunteers to Study Cognitive Functions

Condition:   Healthy Volunteers
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified June 2016

Percutaneous Left Ventricular Reshaping to Reduce Functional Mitral Regurgitation and Improve LV Function

Condition:   Functional Mitral Regurgitation
Intervention:   Device: GDS Accucinch®
Sponsor:   Guided Delivery Systems Inc.
Completed - verified June 2016

The Effect of Coltect (Selenium, Curcumin and Green Tea) on Irritable Bowel Syndrome

Condition:   Irritable Bowel Syndrome
Interventions:   Dietary Supplement: coltect;   Dietary Supplement: Placebo
Recruiting - verified June 2016

New Techniques to Evaluate Mitral Regurgitation

Condition:   Mitral Valve Regurgitation
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified June 2016

Letrozole in Preventing Breast Cancer in Postmenopausal Women With a BRCA1 or BRCA2 Mutation

Conditions:   brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer;   Hereditary Breast/Ovarian Cancer (brca1, brca2)
Interventions:   Drug: letrozole;   Drug: Placebo
Sponsor:   UNICANCER
Active, not recruiting - verified June 2016