Mitral Valve Regurgitation

Clinical Trial Finder

Many patients with mitral valve regurgitation are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Belgian Mitraclip Registry

Condition:   Mitral Valve Insufficiency
Intervention:   Device: mitraclip
Sponsor:   Universiteit Antwerpen
Recruiting - verified July 2015

Evaluation of Safety and Efficacy of Electrochemotherapy in the Treatment of Pancreatic Adenocarcinoma

Condition:   Pancreatic Adenocarcinoma
Interventions:   Device: Electroporation;   Drug: gemcitabine;   Drug: nab-paclitaxel
Sponsor:   The University of Texas Health Science Center, Houston
Not yet recruiting - verified July 2015

NAFLD in Adolescents and Young Adults With PCOS

Conditions:   Polycystic Ovary Syndrome;   Non-Alcoholic Fatty Liver Disease;   Metabolic Syndrome
Intervention:   Other: There is no intervention
Sponsor:   Columbia University
Recruiting - verified July 2015

Prospective Record Of the Use of Dabigatran in Patients With Acute Stroke or TIA

Conditions:   Brain Ischemia With Non-valvular Atrial Fibrillation;   Transient Ischemic Attack With Non-valvular Atrial Fibrillation
Sponsor:   University Hospital, Essen
Recruiting - verified July 2015

Selenium and Ischemic Stroke Outcome

Condition:   Ischemic Stroke
Interventions:   Drug: Selenium;   Drug: normal saline
Sponsor:   Mazandaran University of Medical Sciences
Not yet recruiting - verified July 2015

Proof-of-concept Trial of IVA337 in Diffuse Cutaneous Systemic Sclerosis

Conditions:   Scleroderma, Diffuse;   Diffuse Cutaneous Systemic Sclerosis
Interventions:   Drug: IVA337;   Drug: Placebo
Sponsor:   Inventiva Pharma
Not yet recruiting - verified July 2015

A Clinical Study of the CardiAQ™ TMVI System (Transapical DS)

Conditions:   Mitral Insufficiency;   Heart Valve Disease;   Cardiovascular Disease;   Heart Disease
Intervention:   Device: CardiAQ TMVI System (Transapical DS)
Sponsor:   CardiAQ Valve Technologies, Inc.
Recruiting - verified July 2015

A Study of the Efficacy and Safety of Tocilizumab in Participants With Systemic Sclerosis (SSc) [focuSSced]

Condition:   Sclerosis, Systemic
Interventions:   Drug: Placebo;   Drug: Tocilizumab
Sponsor:   Hoffmann-La Roche
Not yet recruiting - verified July 2015

Safety and Feasibility Study of the Harpoon Medical Device

Conditions:   Mitral Valve Regurgitation;   Mitral Valve Prolapse;   Mitral Valve Insufficiency
Intervention:   Device: Mitral Valve Repair
Sponsor:   Harpoon Medical
Recruiting - verified April 2015

Canadian Study of the MicroVention Flow Re-Direction (FRED) Endoluminal Device Stent System in the Treatment of Intracranial Aneurysms

Condition:   Intracranial Aneurysms
Intervention:   Device: FRED
Sponsor:   Centre hospitalier de l'Université de Montréal (CHUM)
Withdrawn - verified July 2015

Efficacy and Safety of Riociguat in Patients With Systemic Sclerosis

Condition:   Scleroderma, Systemic
Interventions:   Drug: Riociguat (Adempas, BAY63-2521);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified July 2015

Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System

Condition:   Mitral Valve Regurgitation
Intervention:   Device: Mitral valve replacement
Sponsor:   Neovasc Inc.
Recruiting - verified July 2015

Investigating the Role of the Polyol Pathway in the Central Nervous System

Condition:   Hyperglycemia
Interventions:   Other: Brain MRS during hyperglycemic clamp;   Other: Analysis of Metabolites in cerebrospinal fluid
Sponsor:   Yale University
Recruiting - verified July 2015

Ledipasvir/Sofosbuvir Fixed-Dose Combination on Cerebral Metabolism and Neurocognition in Treatment-Naive and Treatment-Experienced Participants With Chronic Genotype 1 HCV Infection

Condition:   Hepatitis C Virus Infection
Interventions:   Drug: LDV/SOF;   Drug: Placebo to match LDV/SOF
Sponsor:   Gilead Sciences
Active, not recruiting - verified July 2015

Intracerebral Hemorrhage Deferoxamine Trial - iDEF Ttrial

Condition:   Intracerebral Hemorrhage
Interventions:   Drug: Deferoxamine Mesylate;   Drug: Placebo (for Deferoxamine Mesylate)
Sponsors:   Beth Israel Deaconess Medical Center;   Medical University of South Carolina;   National Institute of Neurological Disorders and Stroke (NINDS);   Massachusetts General Hospital;   Tufts Medical Center;   University of Massachusetts, Worcester;   University of Pennsylvania;   Johns Hopkins University;   University of Maryland;   Duke University;   University of North Carolina;   University of Florida;   Henry Ford Hospital;   Ohio State University;   St. Joseph's Hospital and Medical Center, Phoenix;   University of California, San Francisco;   Oregon Health and Science University;   Yale New Haven Health System Center for Healthcare Solutions;   University of Iowa;   Hartford Hospital;   The University of Texas Health Science Center, Houston;   Rhode Island Hospital;   Stanford University;   University of Washington;   University of Calgary, Foothills Hospital;   CHU de Québec - Hôpital de l'Enfant-Jésus;   University of Alberta;   Dalhousie University;   Rush University Medical Center;   University Hospital Case Medical Center;   Columbia University;   Weill Medical College of Cornell University;   New York University Langone Medical Center;   Mount Sinai Hospital, New York
Recruiting - verified July 2015

A Study of the Efficacy and Safety of Activase (Alteplase) in Patients With Mild Stroke (PRISMS)

Condition:   Brain Ischemia
Interventions:   Drug: alteplase [Activase];   Drug: alteplase placebo;   Drug: aspirin;   Drug: aspirin placebo
Sponsor:   Genentech, Inc.
Recruiting - verified July 2015

Efficacy and Safety of Sage Tablets Compared to Placebo in Menopausal Patients With Hot Flushes and Sweating

Condition:   Menopausal Hot Flushes
Intervention:   Drug: Sage extract, 3400 mg , DER 1:17
Sponsor:   Bioforce AG
Terminated - verified July 2015

Pacing in First-degree AV-block

Conditions:   First-degree AV-block;   Pacing
Intervention:   Other: Pacing
Sponsors:   Duke University;   Medtronic
Not yet recruiting - verified February 2015

Lactate Imaging as a Tumour Biomarker

Condition:   Cancer
Intervention:   Device: Magnetic Resonance Imaging (MRI)
Sponsors:   Institute of Cancer Research, United Kingdom;   Cancer Research UK
Recruiting - verified July 2015

International Subarachnoid Aneurysm Trial II

Condition:   Intracranial Hemorrhage Ruptured Aneurysm
Interventions:   Procedure: surgical management;   Procedure: Endovascular management
Sponsor:   Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting - verified July 2015

EASE MITRAL Expertise-based Assessment Study on Clinical Efficacy of Profile 3D in MITRAL Valve Annuloplasty

Condition:   Mitral Valve Insufficiency
Sponsor:   Medtronic Bakken Research Center
Active, not recruiting - verified July 2015

University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial)

Conditions:   Nonalcoholic Steatohepatitis;   Nonalcoholic Fatty Liver Disease;   Type 2 Diabetes Mellitus
Interventions:   Drug: Pioglitazone;   Drug: Placebo;   Drug: Pioglitazone;   Drug: Placebo
Sponsors:   University of Florida;   The University of Texas at San Antonio
Completed - verified July 2015

Skeletal Muscle Properties and the Metabolic Cost of Walking Post-stroke

Condition:   Stroke
Interventions:   Behavioral: Treadmill walking;   Other: Magnetic resonance spectroscopy
Sponsors:   Department of Veterans Affairs;   Medical University of South Carolina
Completed - verified July 2015

Impact of GABA-Enhancing Agents on Cortical GABA Concentrations Across the Menstrual Cycle in Women

Condition:   Healthy
Interventions:   Drug: Fluoxetine;   Drug: Zolpidem;   Drug: Progesterone
Sponsor:   Yale University
Completed - verified July 2015

Dynamic Contrast Enhanced MRI (DCE-MRI) Diffusion Weighted MRI (DW-MRI) and Magnetic Resonance Spectroscopy (MRS) of Head and Neck Tumors

Condition:   Head and Neck Cancer
Intervention:   Radiation: DCE-MRI,  DW-MRI and MRS
Sponsors:   Memorial Sloan Kettering Cancer Center;   National Institutes of Health (NIH)
Recruiting - verified July 2015

Diagnostic Procedures in Women With Locally Advanced Breast Cancer Who Are Receiving Chemotherapy Before Breast Cancer Surgery

Condition:   Breast Cancer
Interventions:   Procedure: biopsy;   Procedure: magnetic resonance imaging;   Procedure: radiomammography;   Procedure: ultrasound imaging;   Radiation: gadopentetate dimeglumine;   Drug: chemotherapy
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Active, not recruiting - verified July 2015

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