Mitral Valve Regurgitation

Clinical Trial Finder

Many patients with mitral valve regurgitation are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Evaluation of Outcomes of CRT and MitraClip for Treatment of Low Ejection Fraction and Functional Mitral Regurgitation in HF

Conditions:   Functional Mitral Regurgitation;   Heart Failure
Interventions:   Device: MitraClip;   Drug: Optimal Medical Therapy;   Device: CRT-D
Sponsor:   Montreal Heart Institute
Not yet recruiting - verified December 2016

HighLife™ Transcatheter Mitral Valve Replacement System Study

Conditions:   Mitral Valve Regurgitation;   Mitral Valve Insufficiency
Intervention:   Device: Transcatheter Mitral Valve Replacement
Sponsors:   HighLife SAS;   Meditrial Europe Ltd.;   Action, France
Not yet recruiting - verified November 2016

TRI-REPAIR: TrIcuspid Regurgitation RePAIr With CaRdioband Transcatheter System

Conditions:   Tricuspid Valve Insufficiency;   Tricuspid Regurgitation;   Tricuspid Valve Regurgitation;   Cardiovascular Diseases;   Heart Valve Diseases;   Heart Diseases;   Cardiac Valve Annuloplasty
Intervention:   Device: Cardioband Tricuspid
Sponsor:   Valtech Cardio Ltd
Recruiting - verified November 2016

ADMSCs for the Treatment of Systemic Sclerosis

Condition:   Systemic Sclerosis
Intervention:   Biological: injection of autologous stromal vascular fraction
Sponsors:   The Catholic University of Korea;   Seoul St. Mary's Hospital
Recruiting - verified November 2016

Safety and Efficacy of NA-1 in Subjects Undergoing Endovascular Thrombectomy for Stroke (ESCAPE-NA1)

Condition:   Stroke, Acute
Interventions:   Drug: NA-1, 2.6 mg/kg;   Drug: Placebo
Sponsors:   NoNO Inc.;   University of Calgary
Not yet recruiting - verified December 2016

Effectiveness and Safety of SAR156597 in Treating Diffuse Systemic Sclerosis

Condition:   Systemic Sclerosis
Interventions:   Drug: SAR156597 (ACT14604);   Drug: Placebo
Sponsor:   Sanofi
Recruiting - verified December 2016

Efficacy and Safety Study of CNTO 2476 in Participants With Visual Acuity Impairment Associated With Geographic Atrophy (GA) Secondary to Age Related Macular Degeneration (AMD)

Conditions:   Visual Acuity;   Geographic Atrophy;   Macular Degeneration
Interventions:   Drug: CNTO 2476 (6.0 x 10^4 cells);   Drug: CNTO 2476 (3.0 x 10^5 cells)
Sponsor:   Janssen Pharmaceutical K.K.
Not yet recruiting - verified November 2016

A Study to Evaluate the Efficacy and Safety of TF0023 Spray on Subjects With Ischemic Strokes

Condition:   Ischemic Stroke
Intervention:   Drug: TF0023
Sponsor:   Techfields Inc
Recruiting - verified November 2016

CardiAQ-Edwards™ Transcatheter Mitral Valve Replacement (TMVR) Study

Condition:   Mitral Valve Regurgitation
Intervention:   Device: Transcatheter Mitral Valve Re-placement (TMVR) with the CardiAQ-Edwards™ Transcatheter Mitral Valve
Sponsor:   Edwards Lifesciences
Recruiting - verified December 2016

Edwards Lifesciences CardiAQ™ Transcatheter Mitral Valve Replacement (TMVR) Early Feasibility Study

Condition:   Mitral Valve Regurgitation (Degenerative or Functional)
Intervention:   Device: Transcatheter Mitral Valve Replacement (TMVR)
Sponsor:   Edwards Lifesciences
Recruiting - verified December 2016

INVEST: Minimally Invasive Endoscopic Surgery vs. Medical Management in Supratentorial Intraparenchymal Hemorrhage

Condition:   Intracranial Hemorrhage
Interventions:   Device: Apollo MIES;   Other: Medical Management
Sponsor:   J. Mocco
Not yet recruiting - verified December 2016

Trial of Oxaloacetate in Alzheimer's Disease (TOAD)

Condition:   Alzheimer's Disease (AD)
Intervention:   Drug: Oxaloacetate (OAA)
Sponsor:   Russell Swerdlow, MD
Recruiting - verified November 2016

A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis

Condition:   Scleroderma, Systemic
Interventions:   Drug: Nintedanib;   Drug: Placebo
Sponsor:   Boehringer Ingelheim
Recruiting - verified December 2016

Prospective Record Of the Use of Dabigatran in Patients With Acute Stroke or TIA

Conditions:   Brain Ischemia With Non-valvular Atrial Fibrillation;   Transient Ischemic Attack With Non-valvular Atrial Fibrillation
Sponsor:   University Hospital, Essen
Recruiting - verified November 2016

Study of Compound Edaravone Injection for Treatment of Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke
Interventions:   Drug: Compound Edaravone Injection;   Drug: Edaravone Injection
Sponsor:   Jiangsu Simcere Pharmaceutical Co., Ltd.
Active, not recruiting - verified April 2016

Evaluating Therapeutic Response to Novo-TTF

Condition:   Glioblastoma Multiforme
Intervention:   Device: Novo-TTF
Sponsor:   University of Pennsylvania
Recruiting - verified December 2016

Treatment of Heart Failure and Associated Functional Mitral Valve Regurgitation

Condition:   Mitral Valve Regurgitation
Intervention:   Device: ARTO System
Sponsor:   Mvrx, Inc.
Recruiting - verified November 2016

PKU Kuvan Imaging Study

Condition:   Phenylketonuria
Sponsors:   Boston Children’s Hospital;   Beth Israel Deaconess Medical Center;   Brigham and Women's Hospital
Recruiting - verified November 2016

The Role of Endogenous Lactate in Brain Preservation and Counterregulatory Defenses Against Hypoglycemia

Conditions:   Type 1 Diabetes Mellitus;   Hypoglycemia Unawareness
Interventions:   Behavioral: High intensity exercise;   Behavioral: Lay down comfortably
Sponsors:   Radboud University;   Dutch Diabetes Research Foundation;   European Foundation for the Study of Diabetes
Completed - verified April 2016

Repetitive Transcranial Magnetic Stimulation Equipment Testing and Pilot Study

Condition:   Healthy Volunteer
Intervention:   Device: TMS
Sponsor:   National Institute on Drug Abuse (NIDA)
Recruiting - verified November 2016

Assessment of Cardiopulmonary Function in Duchenne Muscular Dystrophy

Condition:   Muscular Dystrophy, Duchenne
Interventions:   Other: Magnetic Resonance Imaging (MRI);   Other: Pulmonary Function Testing (PFT);   Other: Metabolic Exercise Testing using stationary bicycle;   Other: Echocardiogram
Sponsor:   University of Florida
Recruiting - verified November 2016

Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma

Conditions:   Malignant Glioma;   Refractory Brain Neoplasm;   Recurrent Brain Neoplasm;   Glioblastoma
Interventions:   Biological: IL13Rα2-specific, hinge-optimized, 41BB-costimulatory CAR/truncated CD19-expressing T lymphocytes;   Other: laboratory biomarker analysis;   Other: quality-of-life assessment;   Procedure: Magnetic Resonance Imaging;   Procedure: Magnetic Resonance Spectroscopic Imaging;   Biological: IL13Rα2-specific, hinge-optimized, 41BB-costimulatory CAR/truncated CD19-expressing T lymphocytes
Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI)
Recruiting - verified December 2016

Glutamate, Brain Connectivity and Duration of Untreated Psychosis

Conditions:   Schizophrenia;   Psychosis;   Schizoaffective Disorder
Intervention:   Drug: Risperidone
Sponsor:   University of Alabama at Birmingham
Recruiting - verified November 2016

Testosterone Replacement in Non-alcoholic Steatohepatitis (TEREPINS)

Conditions:   Nonalcoholic Steatohepatitis;   Hypogonadism
Intervention:   Drug: testosterone undecanoate
Sponsors:   Sheffield Teaching Hospitals NHS Foundation Trust;   Bayer
Recruiting - verified December 2016

Skeletal Muscle Biomarkers in People With Fragile Sarcolemmal Muscular Dystrophy

Condition:   Genetic Disorder
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institutes of Health Clinical Center (CC);   University of Massachusetts, Worcester
Recruiting - verified December 2016

Study of Pomalidomide (CC-4047) to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effectiveness for Subjects With Systemic Sclerosis With Interstitial Lung Disease

Conditions:   Scleroderma, Systemic;   Sclerosis, Systemic;   Systemic Scleroderma;   Systemic Sclerosis
Interventions:   Drug: Pomalidomide (CC-4047);   Drug: Placebo
Sponsor:   Celgene Corporation
Active, not recruiting - verified November 2016

A Pilot Clinical Trial of Exendin-4 in Alzheimer's Disease

Conditions:   Alzheimer's Disease;   Mild Cognitive Impairment
Intervention:   Drug: Exendin-4 (Exenatide)
Sponsor:   National Institute on Aging (NIA)
Completed - verified November 2016

Nicotine and Brain Imaging Research Study

Condition:   Nicotine
Sponsor:   University of Pennsylvania
Active, not recruiting - verified December 2016

Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis

Condition:   Sinus Thrombosis, Intracranial
Interventions:   Drug: Endovascular thrombolysis;   Drug: Heparin
Sponsors:   Jan Stam, MD, PhD;   Dutch Heart Foundation
Recruiting - verified November 2016

A Clinical Study to Assess the Safety, Tolerability and Pharmacokinetics of Oral SRT2104 Capsules Administered to Healthy Elderly Subjects for 28 Days

Condition:   Atrophy, Muscular
Interventions:   Drug: Placebo;   Drug: SRT2104
Sponsor:   GlaxoSmithKline
Completed - verified November 2016

The Role of GABA and Neurosteroids in Premenstrual Dysphoric Disorder

Conditions:   Premenstrual Dysphoric Disorder;   Premenstrual Syndrome
Intervention:   Drug: fluoxetine
Sponsors:   University of Pennsylvania;   National Institute of Mental Health (NIMH)
Completed - verified December 2016

Impact of GABA-Enhancing Agents on Cortical GABA Concentrations Across the Menstrual Cycle in Women

Condition:   Healthy
Interventions:   Drug: Fluoxetine;   Drug: Zolpidem;   Drug: Progesterone
Sponsor:   University of Pennsylvania
Completed - verified December 2016

Brain Imaging Study in Menopausal Women With and Without Major Depressive Disorder

Conditions:   Menopause;   Depression
Interventions:   Drug: estrogen alone;   Drug: fluoxetine alone;   Drug: estrogen and fluoxetine together
Sponsor:   University of Pennsylvania
Completed - verified December 2016

Comparison of PET and Proton MRS Imaging to Evaluate Pediatric Brain Tumor Activity

Condition:   Brain Tumors
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified September 2016