Mitral Valve Regurgitation

Clinical Trial Finder

Many patients with mitral valve regurgitation are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Inflammation-Induced CNS Glutamate During Breast Cancer Treatment

Condition:   Breast Cancer
Intervention:  
Sponsor:   Emory University
Not yet recruiting - verified April 2015

Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: Tenecteplase;   Drug: Tissue Plasminogen Activator
Sponsors:   Neuroscience Trials Australia;   The Florey Institute of Neuroscience and Mental Health
Recruiting - verified April 2015

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas or Diffuse Intrinsic Pontine Gliomas

Conditions:   Diffuse Intrinsic Pontine Glioma;   Malignant Glioma;   Recurrent Childhood Brain Neoplasm
Interventions:   Procedure: Diffusion Tensor Imaging;   Procedure: Diffusion Weighted Imaging;   Procedure: Dynamic Contrast-Enhanced Magnetic Resonance Imaging;   Procedure: Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging;   Other: Laboratory Biomarker Analysis;   Procedure: Magnetic Resonance Spectroscopic Imaging;   Biological: Pembrolizumab;   Procedure: Perfusion Magnetic Resonance Imaging
Sponsor:   National Cancer Institute (NCI)
Not yet recruiting - verified February 2015

Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism (RESCUE)-Japan Registry 2

Condition:   Ischemic Stroke
Intervention:   Procedure: endovascular treatment
Sponsor:   Hyogo College of Medicine
Recruiting - verified April 2015

Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism (RESCUE)-Japan RCT

Condition:   Ischemic Stroke
Interventions:   Procedure: Rescue endovascular therapy;   Procedure: No endovascular therapy
Sponsor:   Shinichi Yoshimura
Recruiting - verified April 2015

Early Feasibility Study of the Tendyne Mitral Valve System

Condition:   Mitral Valve Regurgitation
Intervention:   Device: Tendyne Mitral Valve System
Sponsor:   Tendyne Holdings, LLC
Recruiting - verified April 2015

PKU Kuvan Imaging Study

Condition:   Phenylketonuria
Intervention:  
Sponsors:   Children's Hospital Boston;   Beth Israel Deaconess Medical Center;   Brigham and Women's Hospital
Recruiting - verified April 2015

Critical Periods After Stroke Study (CPASS)

Conditions:   Stroke;   Brain Infarction;   Brain Ischemia;   Cerebral Infarction;   Cerebrovascular Disorders
Interventions:   Behavioral: Early Intensive upper extremity motor training;   Behavioral: Sub-acute intensive upper extremity motor training;   Behavioral: Chronic intensive upper extremity motor training
Sponsors:   MedStar National Rehabilitation Network;   Georgetown University;   University of Wisconsin, Madison;   The Catholic University of America;   Medstar Research Institute
Recruiting - verified April 2015

Trevo® Retriever Registry Post Market Surveillance

Condition:   Ischemic Stroke
Intervention:  
Sponsor:   Stryker Neurovascular
Recruiting - verified April 2015

Treatment Differences Between Canagliflozin and Placebo in Insulin Secretion in Subjects With Type 2 Diabetes Mellitus (T2DM)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Canagliflozin, 100 mg;   Drug: Canagliflozin, 300 mg;   Drug: Placebo
Sponsor:   Janssen Research & Development, LLC
Recruiting - verified April 2015

A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome

Condition:   Li-Fraumeni Syndrome
Intervention:   Drug: Metformin
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified July 2014

A Clinical Trial to Evaluate the HeartWare® Ventricular Assist System (ENDURANCE SUPPLEMENTAL TRIAL)

Condition:   Chronic Heart Failure
Interventions:   Device: HeartWare® VAS;   Device: Control LVAD
Sponsor:   HeartWare, Inc.
Recruiting - verified April 2015

NeoChord TACT Post-Market Surveillance Registry

Conditions:   Mitral Valve Insufficiency;   Heart Valve Diseases;   Heart Diseases;   Cardiovascular Diseases
Intervention:  
Sponsor:   NeoChord
Recruiting - verified April 2015

STOP-AUST: The Spot Sign and Tranexamic Acid On Preventing ICH Growth - AUStralasia Trial

Conditions:   Intracerebral Haemorrhage;   Stroke
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsor:   Neuroscience Trials Australia
Recruiting - verified September 2014

Danhong Injection in the Treatment of Acute Ischemic Stroke

Condition:   Acute Stroke
Interventions:   Drug: Danhong injection;   Procedure: Standard medical care;   Drug: placebo
Sponsors:   China  Academy of Chinese Medical Sciences;   China: State Food and Drug Administration
Recruiting - verified April 2015

Clinical Outcome Study for Dysferlinopathy

Conditions:   Dysferlinopathy;   LGMD2B;   Miyoshi Myopathy
Intervention:  
Sponsors:   Newcastle-upon-Tyne Hospitals NHS Trust;   Jain Foundation 
Active, not recruiting - verified October 2012

EXTEND (International): Extending the Time for Thrombolysis in Emergency Neurological Deficits (International)

Condition:   Stroke
Interventions:   Drug: Tissue Plasminogen Activator (Alteplase);   Drug: Placebo
Sponsors:   Neuroscience Trials Australia;   China Medical University Hospital
Recruiting - verified September 2014

Study of Pomalidomide (CC-4047) to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effectiveness for Subjects With Systemic Sclerosis With Interstitial Lung Disease

Conditions:   Scleroderma, Systemic;   Sclerosis, Systemic;   Systemic Scleroderma;   Systemic Sclerosis
Interventions:   Drug: Pomalidomide (CC-4047);   Drug: Placebo
Sponsor:   Celgene Corporation
Active, not recruiting - verified April 2015

Extending the Time for Thrombolysis in Emergency Neurological Deficits - Intra-Arterial

Condition:   Ischemic Stroke
Interventions:   Device: Intra-arterial Clot Retrieval with Solitaire device;   Genetic: intravenous tissue plasminogen activator (tPA)
Sponsor:   Neuroscience Trials Australia
Terminated - verified December 2014

Effect of Azithromycin on Oesophageal Hypomotility

Condition:   Esophageal Motility Disorders
Interventions:   Drug: Azithromycin;   Drug: Placebo
Sponsor:   JAFAR JAFARI
Completed - verified April 2015

Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH-II)

Condition:   Intracerebral Hemorrhage
Intervention:   Drug: Nicardipine hydrochloride
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Medical University of South Carolina;   National Institute of Neurological Disorders and Stroke (NINDS);   Johns Hopkins University;   University of Michigan
Recruiting - verified April 2015

Effects of Wellnara on Climacteric Symptoms

Condition:   Postmenopause
Intervention:   Drug: E2/LNG oral (Wellnara, BAY86-5029)
Sponsor:   Bayer
Completed - verified April 2015

Extending the Time for Thrombolysis in Emergency Neurological Deficits

Condition:   Stroke
Interventions:   Drug: Tissue Plasminogen Activator (Alteplase);   Drug: Placebo
Sponsors:   Neuroscience Trials Australia;   Commonwealth Scientific & Industry Research Organisation;   Brain Research Institute;   University of Melbourne;   Melbourne Health
Recruiting - verified September 2014

Development of Indices Predicting Response to Pre-operative Chemotherapy in Osteosarcoma Patients

Condition:   Osteosarcoma
Intervention:  
Sponsor:   National Cancer Center, Korea
Active, not recruiting - verified April 2015

Non-Invasive Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy Techniques (MRS) for Assessing Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer

Condition:   Breast Cancer
Interventions:   Procedure: Magnetic Resonance Imaging (MRI);   Procedure: Magnetic Resonance Spectroscopy (MRS)
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Active, not recruiting - verified April 2015

Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome

Condition:   Li-Fraumeni Syndrome
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2015

MR Assessment of Brain Function Altered by Lead Exposure

Condition:   Lead Exposure
Intervention:  
Sponsor:   National Institute of Environmental Health Sciences (NIEHS)
Completed - verified April 2015

Genotype - Phenotype Correlations of LINCL

Conditions:   Batten Disease;   Late Infantile Neuronal Lipofuscinosis
Intervention:  
Sponsors:   Weill Medical College of Cornell University;   Nathan's Battle Foundation
Completed - verified April 2015

Phase I Study of Intensity Modulated Radiation Therapy for Prostate Cancer

Condition:   Prostate Cancer
Intervention:   Radiation: Radiation
Sponsor:   National Cancer Institute (NCI)
Completed - verified July 2014

Scleroderma: Cyclophosphamide or Transplantation (SCOT)

Conditions:   Scleroderma, Systemic;   Sclerosis;   Autoimmune Disease
Interventions:   Procedure: Autologous stem cell transplantation;   Drug: Cyclophosphamide;   Drug: Antithymocyte globulin, equine;   Drug: Methylprednisolone;   Drug: Growth colony stimulating factor (G-CSF);   Radiation: Total body irradiation (TBI)
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Active, not recruiting - verified April 2015

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