Mitral Valve Regurgitation

Clinical Trial Finder

Many patients with mitral valve regurgitation are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Genetic, Metabolic, and Growth Factor Repository for Cerebrovascular Disorders

Conditions:   Cerebrovascular Diseases;   Ischemic Stroke;   Repository
Intervention:  
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified September 2016

Hyperpolarized Xenon Imaging in Patients With Cystic Fibrosis

Condition:   Cystic Fibrosis
Intervention:   Other: Hyperpolarized Xenon MRI
Sponsors:   Papworth Hospital NHS Foundation Trust;   University of Sheffield
Not yet recruiting - verified September 2016

The Effect of Intervention With Potassium and/ or Magnesium-enriched Salt on Neurological Performance of Stroke Patients

Condition:   Stroke
Interventions:   Other: Regular salt;   Other: Potassium-enriched salt;   Other: Potassium and magnesium-enriched salt
Sponsor:   Academia Sinica, Taiwan
Completed - verified September 2016

Pituitary Dysfunction After Aneurysmal Subarachnoid Hemorrhage

Conditions:   Thyroid Disfunction;   Subarachnoid Haemorrhage From Cerebral Aneurism Rupture;   Pituitary Disfunction
Interventions:   Biological: Evaluation of pituitary endocrine function;   Behavioral: Evaluation of clinical outcome;   Behavioral: Evaluation of neuropsychological function
Sponsors:   Dr. Rita Bertuetti;   Cambridge University Hospitals NHS Foundation Trust
Not yet recruiting - verified September 2016

A Study Comparing the Effect of Albiglutide With Exenatide on Regional Brain Activity Related to Nausea in Healthy Subjects

Condition:   Diabetes Mellitus
Interventions:   Drug: Albiglutide 50mg;   Drug: Albiglutide matching placebo;   Drug: Exenatide 10microgram;   Drug: Exenatide placebo (saline)
Sponsors:   GlaxoSmithKline;   The General Hospital Corporation d/b/a Massachusetts General Hospital
Not yet recruiting - verified September 2016

A Study to Evaluate the Efficacy and Safety of TF0023 Spray on Subjects With Ischemic Strokes

Condition:   Ischemic Stroke
Intervention:   Drug: TF0023
Sponsor:   Techfields Inc
Recruiting - verified September 2016

A Clinical Study Investigating the Efficacy, Tolerability, and Safety of Continuous Subcutaneous ND0612 Infusion Given as Adjunct Treatment to Oral Levodopa in Patients With Parkinson's Disease With Motor Fluctuations

Condition:   Parkinson's Disease
Interventions:   Drug: ND0612;   Drug: ND0612 Placebo
Sponsor:   NeuroDerm Ltd.
Recruiting - verified May 2016

Low-frequency Pulsed Electromagnetic Fields (ELF-MF) as Treatment for Acute Ischemic Stroke

Conditions:   Stroke, Acute;   Ischemic Stroke
Interventions:   Device: REAL Pulsed ELF-MF stimulation;   Device: SHAM Pulsed ELF-MF stimulation
Sponsors:   Campus Bio-Medico University;   Nuovo Ospedale Civile S.Agostino Estense;   San Raffaele University Hospital, Italy;   University Hospital of Ferrara
Recruiting - verified September 2016

Use of 31P MRS to Assess Brain NAD+ in Healthy Collegiate Football Players

Condition:   Concussion, Mild
Interventions:   Dietary Supplement: Nicotinamide Riboside;   Other: Matching placebo
Sponsors:   Mayo Clinic;   University of Minnesota - Clinical and Translational Science Institute;   Thorne Research Inc.
Recruiting - verified September 2016

Epigenetic Regulation of Human Adipose Tissue Distribution

Condition:   Obesity
Interventions:   Other: Dual-energy X-ray absorptiometry (DEXA)/ Magnetic resonance imaging (MRI) and Magnetic resonance spectroscopy (MRS);   Procedure: Adipose tissue biopsies;   Other: FSIGTT/ RMR
Sponsors:   Translational Research Institute for Metabolism and Diabetes, Florida;   Sanford-Burnham Medical Research Institute
Recruiting - verified September 2016

Clinical Development of MR Spectroscopy and Imaging in Brain Cancers

Conditions:   Malignant Gliomas;   Astrocytomas;   Oligodendrogliomas
Interventions:   Device: 3 Tesla Scanning;   Device: 7 Tesla Scanning
Sponsors:   University of Texas Southwestern Medical Center;   Cancer Prevention Research Institute of Texas
Recruiting - verified September 2016

Testing Glial Pathways to HAAF in Human Subjects Using Carbon 13 Magnetic Resonance Spectroscopy

Conditions:   Diabetes Complications;   Hypoglycemia
Intervention:   Behavioral: Fasting
Sponsor:   Pennington Biomedical Research Center
Recruiting - verified September 2016

European Registry on the ACE Reperfusion Catheters and the Penumbra System in the Treatment of Acute Ischemic Stroke

Condition:   Ischemic Stroke
Intervention:   Device: Penumbra Aspiration System
Sponsor:   Penumbra Inc.
Recruiting - verified September 2016

Tecfidera and MRI for Brain Energy in MS

Condition:   Multiple Sclerosis
Intervention:   Drug: Dimethyl fumarate
Sponsors:   Oregon Health and Science University;   Biogen
Recruiting - verified September 2016

Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of DS-1040b in Subjects With Acute Ischemic Stroke

Conditions:   Acute Ischemic Stroke;   Thrombotic Disease
Interventions:   Drug: DS-1040b;   Drug: placebo
Sponsor:   Daiichi Sankyo Inc.
Recruiting - verified September 2016

A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis

Condition:   Scleroderma, Systemic
Interventions:   Drug: Nintedanib;   Drug: Placebo
Sponsor:   Boehringer Ingelheim
Recruiting - verified September 2016

Neurobiological Adaptations and Pharmacological Interventions in Cocaine Addiction

Condition:   Cocaine Addiction
Interventions:   Drug: N-Acetylcystein;   Drug: Placebo
Sponsors:   Psychiatric University Hospital, Zurich;   Zurich Center for Integrative Human Physiology;   Swiss Federal Institute of Technology;   Max-Planck-Institut Tübingen
Recruiting - verified September 2016

Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: Tenecteplase;   Drug: Tissue Plasminogen Activator
Sponsors:   Neuroscience Trials Australia;   The Florey Institute of Neuroscience and Mental Health
Recruiting - verified September 2016

Clinical Development of Cancer-Specific MRS Biomarkers in Malignant Gliomas

Conditions:   Malignant Gliomas;   Oligodendrogliomas;   Astrocytomas
Intervention:   Device: 3 Tesla scanning
Sponsors:   University of Texas Southwestern Medical Center;   National Institutes of Health (NIH);   National Cancer Institute (NCI)
Recruiting - verified September 2016

Trial of Topical C-82 in Systemic Sclerosis - A Phase I/II Biomarker and Safety Trial

Condition:   Systemic Scleroderma
Interventions:   Drug: C-82 Topical Gel, 1%;   Drug: C-82 Topical Gel, Placebo
Sponsor:   Prism Pharma Co., Ltd.
Completed - verified September 2016

Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion

Conditions:   Nervous System Disorders;   Cerebral Artery
Interventions:   Drug: rt-PA;   Drug: tenecteplase
Sponsor:   University Hospital Center of Martinique
Not yet recruiting - verified September 2016

Efficacy and Safety of Riociguat in Patients With Systemic Sclerosis

Condition:   Scleroderma, Systemic
Interventions:   Drug: Riociguat (Adempas, BAY63-2521);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified September 2016

Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma

Conditions:   Malignant Glioma;   Refractory Brain Neoplasm;   Recurrent Brain Neoplasm
Interventions:   Biological: IL13Rα2-specific, hinge-optimized, 41BB-costimulatory CAR/truncated CD19-expressing T lymphocytes;   Other: laboratory biomarker analysis;   Other: quality-of-life assessment;   Procedure: Magnetic Resonance Imaging;   Procedure: Magnetic Resonance Spectroscopic Imaging
Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI)
Recruiting - verified September 2016

A Feasibility Placebo-Controlled Study of Creatine in Depressed Meth-Using Females

Conditions:   Depression;   Dual Diagnosis;   Drug Addiction
Intervention:   Drug: Creatine monohydrate
Sponsor:   Perry Renshaw
Recruiting - verified September 2016

Assessment of Changes in Metabolic Activity in Liver & Skeletal Muscle in Patients Suffering From Acromegaly

Condition:   Acromegaly
Interventions:   Other: 1H/31P Magnetic Resonance Spectroscopy;   Other: oral glucose tolerance testing;   Other: Thyroid sonography
Sponsor:   Medical University of Vienna
Recruiting - verified September 2016

A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome

Condition:   Li-Fraumeni Syndrome
Intervention:   Drug: Metformin
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting - verified September 2016

Behavioral and Neural Response to Memantine in Adolescents With Autism Spectrum Disorder

Condition:   Autism Spectrum Disorder
Interventions:   Drug: Memantine;   Drug: Placebo
Sponsors:   Massachusetts General Hospital;   Mclean Hospital
Recruiting - verified September 2016

Pivotal Study of the FRED Stent System in the Treatment of Intracranial Aneurysms

Condition:   Intracranial Aneurysms
Intervention:   Device: Flow Re-Direction Endoluminal Device
Sponsor:   Microvention-Terumo, Inc.
Recruiting - verified September 2016

ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)

Conditions:   Aortic Stenosis;   Mitral Stenosis;   Aortic Valve Insufficiency;   Mitral Valve Insufficiency;   Heart Failure
Intervention:   Device: Edwards Aortic and Mitral Bioprostheses Models 11000A and 11000M
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified September 2016

Safety and Performance of the Penumbra Liberty Stent in the Treatment of Wide-Neck, Saccular, Intracranial Aneurysms

Condition:   Wide Neck Intracranial Aneurysms
Intervention:   Device: Liberty Stent
Sponsor:   Penumbra Inc.
Active, not recruiting - verified September 2016

Postprandial IHL and IMCL Measured With Proton Magnetic Resonance Spectroscopy

Condition:   Postprandial IHL and IMCL Dynamics
Interventions:   Dietary Supplement: High fat breakfast;   Dietary Supplement: HF breakfast with protein
Sponsors:   Maastricht University Medical Center;   Top Institute Food and Nutrition
Completed - verified October 2012

STOP-AUST: The Spot Sign and Tranexamic Acid On Preventing ICH Growth - AUStralasia Trial

Conditions:   Intracerebral Haemorrhage;   Stroke
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsor:   Neuroscience Trials Australia
Recruiting - verified September 2016

The Penumbra Liberty Trial: Safety and Effectiveness in the Treatment of Wide-Neck Intracranial Aneurysms

Condition:   Wide-neck, Saccular Intracranial Aneurysms
Intervention:   Device: Stent assisted coiling with the Liberty Stent
Sponsor:   Penumbra Inc.
Active, not recruiting - verified September 2016

A Randomized, Concurrent Controlled Trial to Assess the Safety and Effectiveness of the Separator 3D as a Component of the Penumbra System in the Revascularization of Large Vessel Occlusion in Acute Ischemic Stroke

Condition:   Acute Ischemic Stroke From Large Vessel Occlusion
Interventions:   Device: Penumbra System with Separator 3D;   Device: Penumbra System alone
Sponsor:   Penumbra Inc.
Active, not recruiting - verified September 2016

EXTEND (International): Extending the Time for Thrombolysis in Emergency Neurological Deficits (International)

Condition:   Stroke
Interventions:   Drug: Tissue Plasminogen Activator (Alteplase);   Drug: Placebo
Sponsors:   Neuroscience Trials Australia;   China Medical University Hospital
Recruiting - verified September 2016

Effects of Acute Exercise on Acetylcarnitine Concentration in Endurance Trained and Untrained Subjects

Condition:   Diabetes Mellitus, Type 2
Intervention:   Other: Cycling
Sponsor:   Maastricht University Medical Center
Completed - verified July 2012

Assess the Penumbra System in the Treatment of Acute Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: intravenous (IV) recombinant human tissue plasminogen activator (rtPA);   Device: Penumbra System
Sponsor:   Penumbra Inc.
Active, not recruiting - verified September 2016

Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial

Conditions:   Acute Ischemic Stroke;   Diabetes;   Hyperglycemia
Interventions:   Drug: IV insulin to maintain target glucose concentration of 80-130 mg/dL;   Drug: Standard Care control - sliding scale insulin to keep glucose less than 180 mg/dL
Sponsors:   University of Virginia;   Neurological Emergencies Treatment Trials Network (NETT);   Medical University of South Carolina;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2016

A Study of Survival and Outcome After Stroke

Condition:   Ischemic Stroke
Intervention:  
Sponsor:   Siu Po Sit
Active, not recruiting - verified September 2016

A Clinical Trial to Assess the Acute Safety and Functional Outcome and Recovery After STROKE: The FIRST Trial

Condition:   Stroke
Intervention:   Other: Current standard of care for acute ischemic stroke other than IV rtPA or other IA therapies
Sponsor:   Penumbra Inc.
Active, not recruiting - verified September 2016

Imaging Guided Patient Selection for Interventional Revascularization Therapy

Condition:   Acute Ischemic Stroke
Intervention:   Device: Penumbra System
Sponsor:   Penumbra Inc.
Completed - verified September 2016

Extending the Time for Thrombolysis in Emergency Neurological Deficits

Condition:   Stroke
Interventions:   Drug: Tissue Plasminogen Activator (Alteplase);   Drug: Placebo
Sponsors:   Neuroscience Trials Australia;   Commonwealth Scientific and Industrial Research Organisation, Australia;   Brain Research Institute;   University of Melbourne;   Melbourne Health
Recruiting - verified September 2016

Magna® Mitral Pericardial Bioprostheses Post-Approval Study Protocol

Conditions:   Coronary Artery Disease;   Mitral Valve Regurgitation;   Mitral Valve Incompetence;   Heart Failure
Intervention:   Device: CEP MAGNA MITRAL PERICARDIAL BIOPROSTHESES
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified September 2016

Phase I Study of Intensity Modulated Radiation Therapy for Prostate Cancer

Condition:   Prostate Cancer
Intervention:   Radiation: Radiation
Sponsor:   National Cancer Institute (NCI)
Completed - verified September 2016

Comparison of PET and Proton MRS Imaging to Evaluate Pediatric Brain Tumor Activity

Condition:   Brain Tumors
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified September 2016