Mitral Valve Regurgitation Also called: Mitral Regurgitation (MR)

Clinical Trial Finder

Many patients with mitral valve regurgitation are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

New Techniques to Evaluate Mitral Regurgitation

Condition:   Mitral Valve Regurgitation
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation

Condition:   Mitral Valve Regurgitation
Interventions:   Device: Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR);   Device: Surgical Mitral Valve Replacement (SMVR)
Sponsor:   Medtronic Cardiovascular
Recruiting

A Feasibility Study of the Millipede Transcatheter Annuloplasty Ring System in Patients With Functional Mitral Regurgitation

Conditions:   Mitral Regurgitation Functional;   Mitral Valve Disease;   Cardiovascular Diseases
Intervention:   Device: Millipede Transcatheter Annuloplasty Ring System (Millipede System)
Sponsor:   Boston Scientific Corporation
Not yet recruiting

MRS to Determine Neuroinflammation and Oxidative Stress in MPS I

Condition:   Mucopolysaccharidosis Type I
Intervention:  
Sponsors:   University of Minnesota;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   Lysosomal Disease Network
Completed

Combination of 68Ga-PSMA PET Data With Magnetic Resonance Spectroscopy Data (MRS) for Evaluating Prostate Cancer

Condition:   Prostate Cancer
Intervention:   Diagnostic Test: PET/MR scan
Sponsor:   Tel-Aviv Sourasky Medical Center
Not yet recruiting

NHLBI DIR Transcatheter Mitral Cerclage Annuloplasty Early Feasibility Study

Condition:   Functional Mitral Regurgitation
Intervention:   Device: Transmural Systems Transcatheter Mitral Cerclage Annuloplasty(TMCA)
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

7T MRS in Parkinson's Disease

Condition:   Parkinson's Disease
Intervention:  
Sponsor:   University of Minnesota
Completed

AltaValve Early Feasibility Study Protocol

Conditions:   Mitral Regurgitation;   Mitral Insufficiency;   Mitral Valve Incompetence;   Mitral Valve Regurgitation;   Mitral Incompetence
Intervention:   Device: AltaValve
Sponsor:   4C Medical Technologies, Inc.
Recruiting

Direct Intra-arterial Thrombectomy in Order to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals

Conditions:   Ischemic Stroke;   Large Vessel Occlusion;   Thrombectomy;   Thrombosis;   Alteplase
Interventions:   Procedure: intra-arterial thrombectomy;   Drug: Intravenous thrombolysis
Sponsors:   Changhai Hospital;   National Health and Family Planning Commission, P.R.China;   Wu Jieping Medical Foundation;   Cardiovascular Chinese Research Center;   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Completed

Percutaneous Mitral Valve Intervention: Predicting Improvements in Left Ventricular Performance

Conditions:   Mitral Regurgitation;   Mitral Valve Insufficiency
Intervention:  
Sponsors:   Guy's and St Thomas' NHS Foundation Trust;   King's College Hospital NHS Trust;   Manchester Metropolitan University
Recruiting

DIRECT-SAFE: A Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis With Endovascular Clot Retrieval

Condition:   Ischemic Stroke
Interventions:   Other: Direct endovascular clot retrieval;   Other: Bridging thrombolysis followed by ECR
Sponsors:   Neuroscience Trials Australia;   The Florey Institute of Neuroscience and Mental Health
Recruiting

Earlier Mobilization Post Acute Thrombolysis

Conditions:   Stroke;   Stroke, Acute;   Stroke, Ischemic
Intervention:   Behavioral: Mobilization
Sponsor:   Brian Silver
Not yet recruiting

Earlier Mobilization Post Acute Thrombectomy

Conditions:   Stroke;   Stroke, Acute;   Stroke, Ischemic
Intervention:   Behavioral: Mobilization
Sponsor:   Brian Silver
Not yet recruiting

GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Depression;   Depressive Disorder, Major
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

The Maraviroc Central Nervous System (CNS) Study

Condition:   HIV Infections
Intervention:   Drug: Maraviroc
Sponsors:   Imperial College London;   Pfizer
Completed

ASSIST Registry Studying Various Operator Techniques

Condition:   Ischemic Stroke
Intervention:   Device: Mechanical Thrombectomy
Sponsor:   Stryker Neurovascular
Recruiting

Mitochondria and Chronic Kidney Disease

Conditions:   Hemodialysis-Induced Symptom;   Mitochondrial Diseases
Interventions:   Drug: Icatibant;   Drug: Placebo
Sponsor:   Vanderbilt University Medical Center
Completed

Comparison of PET and Proton MRS Imaging to Evaluate Pediatric Brain Tumor Activity

Condition:   Brain Tumors
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

Measurement of in Vivo Mitochondrial Capacity in Infants

Condition:   Healthy Infants
Intervention:  
Sponsor:   Pennington Biomedical Research Center
Recruiting

Study of Hepatic Function in Patients With Spinal and Bulbar Muscular Atrophy

Conditions:   Spinal and Bulbar Muscular Atrophy;   Motor Neuron Disease
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

The RISE Trial: A Randomized Trial on Intra-Saccular Endobridge Devices

Conditions:   Intracranial Aneurysm;   Brain Aneurysm;   Unruptured Cerebral Aneurysm;   Ruptured Cerebral Aneurysm;   Cerebral Aneurysm
Interventions:   Procedure: surgical clipping, simple coiling, high-porosity stenting with/ without coiling, intra-arterial flow diversion with/ without coiling;   Device: WEB embolization device
Sponsor:   Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting

Brain Bioenergetics in Parkinson's Disease and Response to Repeated Oral UDCA Treatment

Condition:   Parkinson Disease
Intervention:   Drug: ursodeoxycholic acid
Sponsor:   University of Minnesota
Not yet recruiting

Decompressive Hemicraniectomy in Intracerebral Hemorrhage

Condition:   Cerebral Hemorrhage
Interventions:   Procedure: Decompressive craniectomy (DC) and best medical treatment;   Procedure: Best medical treatment
Sponsor:   University Hospital Inselspital, Berne
Recruiting

PRESERVE-MITRAL Post-Market Registry

Condition:   Mitral Valve Disease
Intervention:   Device: Profile 3D™ and CG Future® annuloplasty system
Sponsor:   Medtronic Cardiovascular
Active, not recruiting

Mitochondrial Capacity in Pregnant Women

Conditions:   Pregnancy Related;   Physical Activity
Interventions:   Behavioral: Active;   Behavioral: Sedentary
Sponsor:   Pennington Biomedical Research Center
Active, not recruiting

A Comparison of Hemorrhagic and Ischemic Strokes Among Blacks and Whites

Conditions:   Ischemic Stroke;   TIA;   Hemorrhage
Intervention:  
Sponsors:   University of Cincinnati;   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting

Regional Strategy for Transfer for Mechanical Thrombectomy

Conditions:   Stroke;   Ischemic;   Large Vessel Occlusion
Intervention:   Other: Mechanical thrombectomy
Sponsor:   University Hospital, Montpellier
Recruiting

CNS Changes Following Stroke

Condition:   Stroke
Intervention:   Diagnostic Test: MRI
Sponsor:   University of Zurich
Not yet recruiting

Comprehensive Aneurysm Management Trial

Conditions:   Saccular Aneurysm;   Intracranial Aneurysm;   Unruptured Cerebral Aneurysm
Intervention:   Device: microsurgery; endovascular interventions
Sponsors:   Centre hospitalier de l'Université de Montréal (CHUM);   University of Alberta
Not yet recruiting

Magnetic Resonance Spectroscopy to Evaluate Tourette s Syndrome

Condition:   Tourette Syndrome
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Completed

Intravenous N-acetylcysteine for the Treatment of Gaucher's Disease and Parkinson's Disease

Conditions:   Parkinson's Disease;   Gaucher's Disease
Intervention:   Drug: N-acetylcysteine
Sponsors:   University of Minnesota;   Rare Diseases Clinical Research Network;   National Center for Advancing Translational Science (NCATS);   National Institute of Neurological Disorders and Stroke (NINDS);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Advanced Reperfusion Strategies for Refractory Cardiac Arrest

Conditions:   Cardiac Arrest;   Extracorporeal Membrane Oxygenation Complication;   Ventricular Fibrillation;   Pulseless Ventricular Tachycardia;   Out-Of-Hospital Cardiac Arrest
Interventions:   Device: Early Extracorporeal Membrane Oxygenation (ECMO) Facilitated Resuscitation;   Device: Standard Advanced Cardiac Life Support (ACLS) Resuscitation
Sponsor:   University of Minnesota
Recruiting

THALES - Acute STroke or Transient IscHaemic Attack Treated With TicAgreLor and ASA for PrEvention of Stroke and Death

Conditions:   Acute Ischaemic Stroke;   Transient Ischaemic Attack
Interventions:   Drug: Ticagrelor;   Drug: Placebo
Sponsor:   AstraZeneca
Active, not recruiting

Measuring Effects of Alcohol on Brain Chemistry

Condition:   Healthy Volunteers
Intervention:  
Sponsor:   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Terminated

Effect of Reward on Learning in Motor Cortex

Condition:   Healthy
Intervention:  
Sponsors:   National Institute of Neurological Disorders and Stroke (NINDS);   United States Department of Defense;   National Institutes of Health Clinical Center (CC);   Center for Neuroscience and Regenerative Medicine (CNRM)
Completed

Determine the Effective Dose 95 of Sevoflurane in Adult Patients

Conditions:   Mitral Stenosis;   Mitral Insufficiency;   Tricuspid Stenosis;   Tricuspid Insufficiency
Intervention:  
Sponsor:   Instituto Dante Pazzanese de Cardiologia
Recruiting

Early and Longitudinal Assessment of Neurodegeneration in the Brain and Spinal Cord in Friedreich's Ataxia

Condition:   Friedreich Ataxia
Intervention:  
Sponsors:   University of Minnesota;   Bob Allison Ataxia Research Center;   Friedreich's Ataxia Research Alliance
Enrolling by invitation

Treatment for Non-Alcoholic Fatty Liver With Different Doses of Vitamin E

Condition:   Fatty Liver
Interventions:   Drug: Vitamin E 200 IU/d;   Drug: Vitamin E 400 IU/d;   Drug: Vitamin E 800 IU/d;   Behavioral: Diet and Exercise
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Oltipraz for Liver Fat Reduction in Patients With Non-alcoholic Fatty Liver Disease Except for Liver Cirrhosis

Condition:   Non-Alcoholic Fatty Liver Disease
Interventions:   Drug: Oltipraz;   Drug: Placebos
Sponsor:   PharmaKing
Not yet recruiting

Exercise Study Testing Enhanced Energetics of Muscle Mitochondria in CKD

Conditions:   Moderate-severe Chronic Kidney Disease Not Treated With Dialysis;   Non-insulin Dependent Diabetic Kidney Disease
Intervention:   Behavioral: Combined Aerobic and Resistance Exercise
Sponsor:   University of California, Davis
Not yet recruiting

Recurrent Hypoglycemia in Type 1 Diabetes (Aim 1)

Condition:   Diabetes Mellitus, Type 1
Intervention:   Other: Experimental hypoglycemia
Sponsor:   University of Minnesota
Recruiting

CT-Perfusion for Neurological Diagnostic Evaluation

Condition:   Neurological Determination of Death
Intervention:   Diagnostic Test: Neurological Diagnostic Evaluation
Sponsors:   Centre hospitalier de l'Université de Montréal (CHUM);   Canadian Institutes of Health Research (CIHR)
Recruiting

Radioiodine-avid Bone Metastases From Thyroid Cancer Without Structural Abnormality

Conditions:   Bone Metastases;   Thyroid Cancer
Interventions:   Other: Administrative data;   Other: Clinical data;   Other: Histological data;   Other: Imaging data;   Other: Biological data;   Other: Further treatment
Sponsor:   Hospices Civils de Lyon
Not yet recruiting

MRI Repository for Acute Stroke Clinical and Research Applications

Condition:   Stroke, Acute
Intervention:  
Sponsor:   Johns Hopkins University
Not yet recruiting

Sodium-glucose Co Transporter 2 (sGLT2) Inhibitor and Endogenous Ketone Production

Conditions:   Aging;   Cognitive;   Ketones;   Blood Sugar
Intervention:   Drug: Jardiance 25 mg
Sponsor:   National Institute on Aging (NIA)
Recruiting

Central Nervous System Disease in HIV-infected Children on HAART

Conditions:   HIV Infections;   Central Nervous System Diseases
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Completed

Progesterone in the Treatment of Acute Hemorrhagic Stroke

Condition:   Stroke
Intervention:   Drug: Progesterone
Sponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Korea University Anam Hospital;   Seoul National University Hospital;   Lishui Country People's Hospital;   Jinhua Central Hospital;   Huzhou Central Hospital;   The Affiliated Hospital of Hangzhou Normal University
Not yet recruiting

Berlin PRehospital Or Usual Delivery of Acute Stroke Care

Condition:   Stroke
Interventions:   Procedure: STEMO;   Procedure: Regular care
Sponsors:   Charite University, Berlin, Germany;   Center for Stroke Research Berlin
Completed

Skeletal Muscle Energetics and Fatiguability in Older Individuals

Conditions:   HIV;   HIV Infections
Intervention:  
Sponsors:   Johns Hopkins University;   National Institute on Aging (NIA)
Recruiting

Essential Acute Stroke Care in Low Resource Settings: a Pilot studY

Condition:   Acute Stroke
Intervention:   Other: Acute stroke care Intervention arm
Sponsors:   The George Institute;   World Heart Federation
Not yet recruiting

Calcium for Out-of-Hospital Cardiac Arrest

Condition:   Heart Arrest, Out-Of-Hospital
Interventions:   Drug: Calcium Chloride;   Drug: Sodium chloride 0.9%
Sponsors:   Lars Wiuff Andersen;   Central Denmark Region;   University of Aarhus
Not yet recruiting

Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome

Conditions:   Mitochondrial Disorders;   Li-Fraumeni Syndrome;   Carriers of p53 Mutation
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation

Reliability of the Human Brain Connectome

Condition:   Normal Physiology
Interventions:   Drug: F-18FDG;   Device: MRI
Sponsor:   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting

A Retrospective Study of CT (Computerized Tomography) for Late Window Large Vessel Occlusion (LVO)

Condition:   Stroke, Cardiovascular
Intervention:  
Sponsors:   Boston Medical Center;   Medtronic
Recruiting

Exercise Intolerance in Heart Failure

Condition:   Heart Failure With Normal Ejection Fraction
Intervention:  
Sponsors:   Johns Hopkins University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Safety & Efficacy Study of the Medtronic CoreValve® System-Treatment of Symptomatic Severe Aortic Stenosis With Significant Comorbidities in Extreme Risk Subjects Who Need Aortic Valve Replacement

Condition:   Severe Aortic Stenosis
Intervention:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting

FIrst-Pass Reperfusion With the NeVa Stent-Retriever Trial

Condition:   Acute Ischemic Stroke
Interventions:   Device: NeVa Stent Retrievers;   Device: Solitaire Stent Retrievers
Sponsor:   Vesalio
Not yet recruiting

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

Condition:   Mitral Valve Failure
Interventions:   Device: Edwards SAPIEN 3 transcatheter heart valve;   Device: ASHI INTECC Astato XS 20
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Augmenting Cerebral Blood Flow to Preserve the Penumbra Trial

Condition:   Ischemic Stroke
Intervention:   Device: SPG stimulation
Sponsor:   BrainsGate
Recruiting

Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging

Conditions:   Drug Abuse;   Nicotine Dependence
Intervention:  
Sponsor:   National Institute on Drug Abuse (NIDA)
Recruiting

Effect of Fibre Products on Appetite and Weight

Condition:   Obesity
Interventions:   Dietary Supplement: Propionate ester;   Dietary Supplement: Inulin;   Dietary Supplement: Cellulose
Sponsor:   Imperial College London
Completed

Helping Stroke Patients With ThermoSuit Cooling

Conditions:   Stroke;   Brain Ischemia
Interventions:   Device: ThermoSuit Cooling Induction;   Drug: Magnesium Sulfate;   Drug: tPA;   Drug: Propofol;   Drug: Etomidate;   Procedure: Neurothrombectomy
Sponsors:   Life Recovery Systems;   Tulane University School of Medicine
Recruiting

COMPLETE: International Acute Ischemic Stroke Registry With the Penumbra System Aspiration Including the 3D Revascularization Device

Condition:   Stroke, Ischemic
Intervention:   Device: Penumbra System
Sponsor:   Penumbra Inc.
Active, not recruiting

Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

Condition:   CAD
Interventions:   Device: MRI scan x 1 Healthy Volunteer;   Device: MRI scan x 2 Healthy Volunteer;   Device: MRI scan x 2 - CAD patients;   Device: MRI scan x 2- non CAD patients
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

LOTUS: Global Acute Stroke Study Utilizing Penumbra System

Condition:   Stroke, Ischemic
Intervention:   Device: Penumbra System
Sponsor:   Penumbra Inc.
Not yet recruiting

A Placebo-Controlled Effectiveness in INPH Shunting (PENS) Trial

Condition:   Idiopathic Normal Pressure Hydrocephalus (INPH)
Intervention:   Device: programmable CSF shunt valve
Sponsors:   Johns Hopkins University;   University of Utah
Recruiting

Destination Therapy Post Approval Study

Condition:   Chronic Heart Failure
Intervention:   Device: HeartWare Ventricular Assist Device
Sponsor:   Medtronic Cardiac Rhythm and Heart Failure
Recruiting

Study of New Magnetic Resonance Methods

Condition:   Healthy
Intervention:  
Sponsor:   National Institutes of Health Clinical Center (CC)
Terminated

Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction

Condition:   Normal Physiology
Interventions:   Other: MRI;   Other: Neurometer CPT/C
Sponsor:   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting

Fimasartan Blood Pressure Lowering After Acute Stroke

Conditions:   Hypertension;   Ischemic Stroke;   Transient Ischemic Attack
Intervention:  
Sponsor:   Boryung Pharmaceutical Co., Ltd
Completed

Clinical Comparative Analysis of Bretschneider and St. Thomas Cardioplegia Solution in Case of Mitral Valve Repair Via Anterolateral Right Thoracotomy

Condition:   Mitral Valve Reconstruction
Interventions:   Other: cardioplegia with HTK-Bretschneider cardioplegic solution;   Other: cardioplegia with St. Thomas cardioplegic solution
Sponsor:   University Hospital, Basel, Switzerland
Completed

Fingolimod as a Treatment of Cerebral Edema After Intracerebral Hemorrhage

Conditions:   Intracerebral Hemorrhage;   Cerebral Edema;   Stroke Hemorrhagic;   Intracerebral Hemorrhage, Hypertensive;   Intracerebral Hemorrhage Intraparenchymal
Interventions:   Drug: Fingolimod 0.5 mg;   Drug: Placebo;   Other: Standard of care
Sponsor:   Wake Forest University Health Sciences
Not yet recruiting

Electrical Activation Mapping Guided Tailor Made Approach for Cardiac Resynchronization Therapy

Condition:   Heart Failure
Intervention:   Procedure: Noninvasive electrical dyssynchrony study
Sponsor:   Chinese University of Hong Kong
Recruiting

Nicotine Withdrawal Symptoms and Smoking Relapse

Condition:   Nicotine Dependence
Intervention:  
Sponsor:   National Institute on Drug Abuse (NIDA)
Recruiting

Effectiveness of TCC Followed by MBCT and Predictive Factors (Genetic, Clinical and Cognitive) Response

Conditions:   Bipolar Disorder;   Anxious Disorder;   Alcohol Dependence
Interventions:   Behavioral: Cognitive and Behavior Therapy (CBT);   Behavioral: Mindfulness Based Cognitive Therapy (MBCT)
Sponsor:   Centre Hospitalier St Anne
Terminated

Effects of Chi Kung to Improve the Symptoms of Menopause

Condition:   Quality of Life and Menopause
Intervention:   Other: Chi Kung group
Sponsor:   University of Jaén
Completed

Efficacy and Safety Study of Satralizumab (SA237) as Monotherapy to Treat Participants With Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD)

Conditions:   Neuromyelitis Optica (NMO);   NMO Spectrum Disorder (NMOSD)
Interventions:   Drug: Satralizumab;   Drug: Placebo
Sponsors:   Hoffmann-La Roche;   Chugai Pharmaceutical
Active, not recruiting

Protective Effects of RIC in Elderly With Acute Ischemic Stroke Complicating Acute Coronary Syndrome

Conditions:   Elderly Patients;   Acute Ischemic Stroke;   Acute Coronary Syndrome
Interventions:   Device: RIC;   Device: sham-RIC
Sponsor:   Capital Medical University
Not yet recruiting

Early Versus Late Initiation of Direct Oral Anticoagulants in Post-ischaemic Stroke Patients With Atrial fibrillatioN (ELAN): an International, Multicentre, Randomised-controlled, Two-arm, Assessor-blinded Trial

Condition:   Ischaemic Stroke
Interventions:   Drug: Early treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®);   Drug: Late treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®)
Sponsor:   University Hospital Inselspital, Berne
Recruiting

Tryptophan MRI in People With Schizophrenia and Healthy Controls

Condition:   Schizophrenia
Interventions:   Drug: Tryptophan;   Drug: Placebo
Sponsors:   University of Maryland, Baltimore;   Mitsubishi Tanabe Pharma Corporation;   National Institute of Mental Health (NIMH)
Active, not recruiting

Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations

Conditions:   Advanced Malignant Solid Neoplasm;   Glioblastoma;   Recurrent Cholangiocarcinoma;   Recurrent Glioma;   Recurrent Malignant Solid Neoplasm;   WHO Grade II Glioma;   WHO Grade III Glioma
Interventions:   Other: Laboratory Biomarker Analysis;   Drug: Olaparib
Sponsor:   National Cancer Institute (NCI)
Recruiting

A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel

Conditions:   Acute Ischemic Stroke;   Transient Ischemic Attack (TIA)
Interventions:   Drug: BMS-986177;   Other: Placebo;   Drug: Clopidogrel;   Drug: Aspirin
Sponsors:   Bristol-Myers Squibb;   Janssen, LP
Recruiting

Treatment of Hamstring Muscle in Patients With Low-back Pain

Condition:   Low Back Pain
Interventions:   Other: Dry needling in hamstring muscle trigger points;   Other: Dry needling in hamstring muscle not trigger points
Sponsor:   University of Alcala
Recruiting

Endovascular Treatment Key Technique and Emergency Work Flow Improvement of Acute Ischemic Stroke (ANGEL-ACT): Phase Two

Condition:   Intracranial Artery Occlusion With Infarction (Disorder)
Intervention:   Behavioral: ANGEL Intervention Package and Toolbox
Sponsor:   Beijing Tiantan Hospital
Recruiting

EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)

Conditions:   Intracranial Hemorrhages;   Atrial Fibrillation
Interventions:   Drug: Edoxaban;   Other: Non-anticoagulant medical therapy
Sponsor:   Population Health Research Institute
Recruiting

Covers to Improve Esthetic Outcome After Surgery for Chronic Subdural Hematoma

Conditions:   Hematoma, Subdural, Chronic;   Hematoma, Subdural, Intracranial;   Haematoma;Subdural;Traumatic
Interventions:   Device: Placement of burr-hole covers;   Other: No placement of burr-hole covers
Sponsors:   University of Zurich;   Stryker European Operations BV
Recruiting

Xingnaojing for Mild-to-severe Acute Ischemic Stroke

Conditions:   Acute Ischemic Stroke;   Stroke, Acute;   Stroke, Ischemic
Interventions:   Drug: Xingnaojing injection;   Drug: Xingnaojing placebo injection;   Other: Standard care
Sponsors:   Dongzhimen Hospital, Beijing;   Peking University Third Hospital;   Beijing Shuyi Hospital;   The Airport Hospital of Shunyi District Beijing;   Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine;   The NO.4 People's Hospital of Hengshui;   The Second Hospital of Hebei Medical University;   The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine;   The Affiliated Hospital of Shaanxi University of Chinese Medicine;   Tianshui Hospital of Traditional Chinese Medicine;   The Affiliated Hospital of Changzhi Academy of TCM;   Zibo Hospital of Traditional Chinese Medicine;   Yantai Yuhuangding Hospital;   Shandong University of Traditional Chinese Medicine;   Zhejiang Provincial Hospital of TCM;   Zhejiang Provincial Tongde Hospital;   Second Affiliated Hospital of Wenzhou Medical University;   People's Hospital of Quzhou;   Longhua Hospital;   The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine;   Taizhou Hospital of Traditional Chinese Medicine;   The First Affiliated Hospital of Guizhou University of TCM;   Guangzhou Hospital of Traditional Chinese Medicine;   The First Affiliated Hospital of Guangxi University of Chinese Medicine;   Liling Hospital of Traditional Chinese Medicine;   Hunan Academy of Traditional Chinese Medicine Affiliated Hospital;   Hubei Hospital of Traditional Chinese Medicine;   First Hospital of Jilin University;   Anshan Central Hospital;   The Affiliated Hospital of Liaoning University of TCM;   The First Hospital of Qiqihar City;   Haikou People's Hospital;   The Second People's Hospital of Anhui Province;   The Third Affiliated Hospital of Shenzhen University;   The third people's Hospital of Hubei Province;   The First Affiliated Hospital of Henan University of Traditional Chinese Medicine;   The Third Hospital of Xi'an City
Not yet recruiting

MRI and PET Imaging in Predicting Treatment Response in Patients With Stage IB-IVA Cervical Cancer

Conditions:   Cervical Adenocarcinoma;   Cervical Adenosquamous Carcinoma;   Cervical Squamous Cell Carcinoma, Not Otherwise Specified;   Cervical Undifferentiated Carcinoma;   Recurrent Cervical Carcinoma;   Stage IB2 Cervical Cancer;   Stage II Cervical Cancer;   Stage IIA Cervical Cancer;   Stage IIB Cervical Cancer;   Stage III Cervical Cancer;   Stage IIIA Cervical Cancer;   Stage IIIB Cervical Cancer;   Stage IVA Cervical Cancer
Interventions:   Procedure: Computed Tomography;   Procedure: Diffusion Weighted Imaging;   Procedure: Dynamic Contrast-Enhanced Magnetic Resonance Imaging;   Radiation: Fludeoxyglucose F-18;   Procedure: Magnetic Resonance Spectroscopic Imaging;   Procedure: Positron Emission Tomography
Sponsors:   University of Washington;   National Cancer Institute (NCI)
Recruiting

Brentuximab Vedotin for Systemic Sclerosis

Conditions:   Diffuse Cutaneous Systemic Sclerosis;   Scleroderma;   dcSSc
Interventions:   Biological: Brentuximab Vedotin;   Biological: Placebo
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Immune Tolerance Network (ITN);   Seattle Genetics, Inc.
Recruiting