Mitral Valve Regurgitation

Clinical Trial Finder

Many patients with mitral valve regurgitation are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Mechanisms of Non-Invasive Neuromodulation Interventions: Influence on Human Neurochemistry and Functional Connectivity

Condition:   Repetitive Transcranial Magnetic Stimulation (rTMS)
Interventions:   Device: Inhibitory rTMS (1 Hz);   Device: Excitatory rTMS (5 Hz)
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Not yet recruiting - verified February 2016

Evaluation of the Minimally Invasive VenTouch System in the Treatment of Functional Mitral Regurgitation (FMR)

Condition:   Functional Mitral Regurgitation
Intervention:   Device: VenTouch System Implant
Sponsor:   Mardil Medical
Recruiting - verified January 2016

European Registry on the ACE Reperfusion Catheters and the Penumbra System in the Treatment of Acute Ischemic Stroke

Condition:   Ischemic Stroke
Intervention:   Device: Penumbra Aspiration System
Sponsor:   Penumbra Inc.
Not yet recruiting - verified February 2016

The Fluid Therapy Strategy of the Non-dehydrated Patients With Acute Ischemic Stroke.

Conditions:   Stroke;   Dehydration
Intervention:   Dietary Supplement: water
Sponsor:   Chang Gung Memorial Hospital
Recruiting - verified January 2016

Prognostic Observation of Posterior Reversible Encephalopathy Syndrome

Condition:   Posterior Reversible Encephalopathy Syndrome
Sponsors:   Yantai Yuhuangding Hospital;   University of Southern California
Not yet recruiting - verified February 2016

Expiratory Flow Limitation and Mechanical Ventilation During Cardiopulmonary Bypass in Cardiac Surgery

Conditions:   Mitral Regurgitation;   Aortic Regurgitation
Interventions:   Procedure: No ventilation during CPB;   Procedure: Ventilation with CPAP during CPB;   Procedure: Ventilation with low tidal volume during CPB
Sponsor:   Ospedale San Raffaele
Not yet recruiting - verified February 2016

GLP-1 and Hyperoxia for Organ Protection in Heart Surgery

Conditions:   Coronary Disease;   Shock, Cardiogenic;   Renal Failure;   Stroke;   Brain Injury;   Aortic Valve Disease
Interventions:   Drug: Byetta (Lilly, Exenatide);   Drug: Conoxia (AGA, oxygen);   Drug: 20% Human Albumin
Sponsor:   Rigshospitalet, Denmark
Not yet recruiting - verified February 2016

A Double-Blinded Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986020 Versus Placebo in Diffuse Cutaneous Systemic Sclerosis (dcSSc)

Condition:   Scleroderma
Interventions:   Drug: BMS-986020;   Other: Placebo
Sponsor:   Bristol-Myers Squibb
Not yet recruiting - verified December 2015

A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis

Condition:   Scleroderma, Systemic
Interventions:   Drug: Nintedanib;   Drug: Placebo
Sponsor:   Boehringer Ingelheim
Recruiting - verified February 2016

Proof-of-concept Trial of IVA337 in Diffuse Cutaneous Systemic Sclerosis

Conditions:   Scleroderma, Diffuse;   Diffuse Cutaneous Systemic Sclerosis
Interventions:   Drug: IVA337;   Drug: Placebo
Sponsor:   Inventiva Pharma
Recruiting - verified February 2016

Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia

Condition:   Brain Hypoxia
Intervention:   Device: Mild Hypoxia
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Active, not recruiting - verified February 2016

Quality of Life After Stroke Using a Telemedicine-based Stroke Network

Condition:   Stroke
Intervention:   Drug: Alteplase
Sponsors:   Thomas Jefferson University;   Genentech, Inc.
Recruiting - verified February 2016

Safety and Early Feasibility Study of the Harpoon Medical Device

Conditions:   Mitral Valve Regurgitation;   Mitral Valve Prolapse;   Mitral Valve Insufficiency
Intervention:   Device: Mitral Valve Repair
Sponsor:   Harpoon Medical
Recruiting - verified February 2016

Rehabilitation Training After Stroke

Condition:   Stroke
Intervention:   Other: Rehabilitation
Sponsors:   NIHR Exeter Clinical Research Facility;   The Stroke Association, United Kingdom;   University of Exeter
Active, not recruiting - verified February 2016

CARILLON Mitral Contour System® for Reducing Functional Mitral Regurgitation

Conditions:   Mitral Valve Insufficiency;   Heart Failure
Intervention:   Device: CARILLON Mitral Contour System
Sponsors:   Cardiac Dimensions Pty Ltd;   Menzies Institute for Medical Research
Recruiting - verified February 2016

Metabolic Anomolies Associated With the 6 Month Clinical Evolution of Patients Suffering From Motor Conversion Disorder

Condition:   Conversion Disorder
Intervention:   Device: PET CT 18 FDG
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Recruiting - verified February 2016

Exenatide Compared With Insulin Glargine to Change Liver Fat Content in Type 2 Diabetes

Conditions:   Diabetes Mellitus, Type 2;   Non-alcoholic Fatty Liver Disease
Interventions:   Drug: Exenatide;   Drug: insulin glargine
Sponsors:   Fudan University;   Huadong Hospital;   Shanghai Minhang Central Hospital;   Shanghai 6th People's Hospital;   Shanghai Changzheng Hospital
Recruiting - verified November 2015

PKU Kuvan Imaging Study

Condition:   Phenylketonuria
Sponsors:   Children's Hospital Boston;   Beth Israel Deaconess Medical Center;   Brigham and Women's Hospital
Recruiting - verified February 2016

Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System

Condition:   Mitral Valve Regurgitation
Intervention:   Device: Mitral valve replacement
Sponsor:   Neovasc Inc.
Recruiting - verified January 2016

Ambulatory Electrocardiographic Monitoring for the Detection of High-Degree Atrio-Ventricular Block in Patients With New-onset PeRsistent LEft Bundle Branch Block After Transcatheter Aortic Valve Implantation. The "MARE" Study

Conditions:   Aortic Valve Disease;   Conduction Disturbances
Intervention:   Device: Implantable loop recorders system Reveal ICM LINQ®,
Sponsor:   Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Recruiting - verified February 2016

Trevo and Medical Management Versus Medical Management Alone in Wake Up and Late Presenting Strokes

Condition:   Ischemic Stroke
Interventions:   Device: Trevo Thrombectomy Procedure;   Other: Medical Management
Sponsor:   Stryker Neurovascular
Recruiting - verified February 2016

The Role of Dopaminergic and Glutamatergic Neurotransmission for Dysfunctional Learning in Alcohol Use Disorders

Condition:   Alcohol Use Disorder
Intervention:   Other: Alcohol detoxification
Sponsors:   Technische Universität Dresden;   Charite University, Berlin, Germany
Enrolling by invitation - verified February 2016

A Study of the Efficacy and Safety of Activase (Alteplase) in Patients With Mild Stroke (PRISMS)

Condition:   Brain Ischemia
Interventions:   Drug: alteplase [Activase];   Drug: alteplase placebo;   Drug: aspirin;   Drug: aspirin placebo
Sponsor:   Genentech, Inc.
Recruiting - verified February 2016

Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection - TREAT-CAD

Condition:   Cervical Artery Dissection
Interventions:   Drug: Acetylsalicylic acid;   Drug: vitamin K-antagonist
Sponsors:   University Hospital, Basel, Switzerland;   University Hospital Inselspital, Berne;   University of Lausanne Hospitals
Recruiting - verified February 2016

Treatment Differences Between Canagliflozin and Placebo in Insulin Secretion in Subjects With Type 2 Diabetes Mellitus (T2DM)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Canagliflozin, 100 mg;   Drug: Canagliflozin, 300 mg;   Drug: Placebo
Sponsor:   Janssen Research & Development, LLC
Recruiting - verified January 2016

Finding the Optimal Cooling tempeRature After Out-of-HoSpiTal Cardiac Arrest

Condition:   Out-Of-Hospital Cardiac Arrest.
Interventions:   Device: Target Temperature Management of 34°C;   Device: Target Temperature Management of 32°C;   Device: Target Temperature Management of 33°C
Sponsors:   ZOLL Circulation, Inc., USA;   Instituto de Investigación Hospital Universitario La Paz
Recruiting - verified February 2016

A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome

Condition:   Li-Fraumeni Syndrome
Intervention:   Drug: Metformin
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified June 2015

Proton MR Spectroscopy and 18F-Fluorocholine PET for Breast Cancer Diagnosis

Conditions:   Breast Cancer Diagnosis;   Positron Emission Tomography;   Magnetic Resonance Imaging
Interventions:   Drug: 18F-FCH;   Drug: Magnevist
Sponsor:   National Taiwan University Hospital
Active, not recruiting - verified February 2016

Testosterone Replacement in Non-alcoholic Steatohepatitis (TEREPINS)

Conditions:   Nonalcoholic Steatohepatitis;   Hypogonadism
Intervention:   Drug: testosterone undecanoate
Sponsors:   Sheffield Teaching Hospitals NHS Foundation Trust;   Bayer
Recruiting - verified January 2016

Lactate Imaging as a Tumour Biomarker

Condition:   Cancer
Intervention:   Device: Magnetic Resonance Imaging (MRI)
Sponsors:   Institute of Cancer Research, United Kingdom;   Cancer Research UK
Recruiting - verified February 2016

Study of the Prevalence and Associated Factors With Hypogonadism in HIV + Men

Conditions:   Hypogonadism;   HIV
Sponsor:   Tourcoing Hospital
Recruiting - verified January 2016

The Study of Breast MRI Screening and Proton Magnetic Resonance Spectroscopy

Condition:   Breast Diseases
Intervention:   Procedure: proton magnetic resonance spectroscopy
Sponsor:   National Taiwan University Hospital
Completed - verified February 2016

A Study to Evaluate the Effect of Aleglitazar on Cardiac Energetics and Function in Patients With Type 2 Diabetes Mellitus and no History of Coronary Artery Disease

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: aleglitazar;   Drug: placebo
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

Attenuation of Corticosteroid Induced Hippocampal Changes

Condition:   Organic Memory Impairment
Interventions:   Drug: Memantine;   Drug: Placebo
Sponsors:   University of Texas Southwestern Medical Center;   National Institute on Drug Abuse (NIDA)
Recruiting - verified February 2016

Cardioband Adjustable Annuloplasty System for Minimally Invasive Mitral Valve Repair

Condition:   Mitral Valve Insufficiency
Intervention:   Device: Cardioband adjustable band
Sponsor:   Valtech Cardio Ltd
Recruiting - verified January 2016

A Study of RoActemra/Actemra (Tocilizumab) Versus Placebo in Patients With Systemic Sclerosis

Condition:   Sclerosis, Systemic
Interventions:   Drug: Placebo;   Drug: tocilizumab [RoActemra/Actemra];   Drug: tocilizumab [RoActemra/Actemra]
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

Nicotine Withdrawal Symptoms and Smoking Relapse

Condition:   Nicotine Dependence
Sponsor:   National Institute on Drug Abuse (NIDA)
Recruiting - verified July 2015

Endophenotyping With Functional Magnetic Resonance Imaging (fMRI)

Condition:   Alcohol Dependence
Sponsors:   Charite University, Berlin, Germany;   Central Institute of Mental Health, Mannheim;   University Hospital, Bonn
Completed - verified January 2016

A Study of RO5093151 in Patients With Non-Alcoholic Fatty Liver Disease

Condition:   Fatty Liver, Non-alcoholic Fatty Liver Disease, NAFLD
Interventions:   Drug: Placebo;   Drug: RO5093151
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

Vagus Nerve Stimulation Clinical Outcomes Measured Prospectively in Patients Stimulated

Condition:   Epilepsy
Sponsor:   Cyberonics, Inc.
Recruiting - verified February 2016

EARLYdrain - Outcome After Early Lumbar CSF-drainage in Aneurysmal SAH

Condition:   Aneurysmal Subarachnoid Hemorrhage
Intervention:   Procedure: Insertion of a lumbar drain
Sponsor:   Charite University, Berlin, Germany
Active, not recruiting - verified January 2016

EASE MITRAL Expertise-based Assessment Study on Clinical Efficacy of Profile 3D in MITRAL Valve Annuloplasty

Condition:   Mitral Valve Insufficiency
Sponsor:   Medtronic Bakken Research Center
Active, not recruiting - verified February 2016

A Test of Nutritional Interventions to Enhance Weight Loss Maintenance

Conditions:   Overweight;   Obesity;   Weight Loss Maintenance
Interventions:   Behavioral: Behavior Therapy;   Dietary Supplement: Meal Replacements;   Behavioral: Nutritrol
Sponsors:   Drexel University;   University of Pennsylvania
Active, not recruiting - verified February 2016

Intermittent Theta Burst Stimulation (iTBS) for the Treatment of Negative Symptoms in Schizophrenia

Condition:   Schizophrenia
Interventions:   Procedure: active iTBS;   Procedure: sham iTBS
Sponsor:   Hôpital le Vinatier
Completed - verified January 2016

Magna® Mitral Pericardial Bioprostheses Post-Approval Study Protocol

Conditions:   Coronary Artery Disease;   Mitral Valve Regurgitation;   Mitral Valve Incompetence;   Heart Failure
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified February 2016

The Effect of Plasma Osmolality on Brain Glutamate

Condition:   Schizophrenia
Intervention:   Drug: furosemide, Na supplements
Sponsor:   Yale University
Completed - verified August 2012