Mitral Valve Regurgitation

Clinical Trial Finder

Many patients with mitral valve regurgitation are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

High and Intermediate Risk Degenerative Mitral Regurgitation Treatment: A Trial Comparing MitraClip® to Surgical Therapy

Condition:   Mitral Valve Insufficiency
Interventions:   Device: MitraClip®;   Procedure: Mitral valve Surgery
Sponsor:   University of Zurich
Recruiting - verified August 2015

Early Feasibility Study of the CardiAQ™ TMVI System (Transfemoral and Transapical DS)

Conditions:   Mitral Insufficiency;   Heart Valve Disease;   Cardiovascular Disease;   Heart Disease
Intervention:   Device: CardiAQ TMVI System (Transapical & Transfemoral DS)
Sponsor:   CardiAQ Valve Technologies, Inc.
Recruiting - verified August 2015

A Safety and Effective Study of Ginkgolides Diterpene Lactone Meglumine Injection in the Treatment of Ischemic Stroke.

Condition:   Ischemic Stroke
Interventions:   Drug: Ginkgo diterpene lactone meglumine injection;   Drug: Ginkgo diterpene lactone meglumine injection simulation
Sponsors:   Ministry of Science and Technology of the People´s Republic of China;   Beijing Bionovo Medicine Development Co., Ltd.
Recruiting - verified August 2015

MRI and Metabolomics Biomarkers for Uterine Malignancy

Condition:   Uterine Neoplasms
Sponsor:   Chang Gung Memorial Hospital
Not yet recruiting - verified August 2015

A Study of the Efficacy and Safety of Tocilizumab in Participants With Systemic Sclerosis (SSc) [focuSSced]

Condition:   Sclerosis, Systemic
Interventions:   Drug: Placebo;   Drug: Tocilizumab
Sponsor:   Hoffmann-La Roche
Not yet recruiting - verified August 2015

Treatment of Refractory Auditory Verbal Hallucinations With tDCS in Schizophrenia

Condition:   Schizophrenia
Intervention:   Device: tDCS
Sponsor:   Seoul National University Hospital
Not yet recruiting - verified April 2015

MRSI Guided Dose Escalated Radiation in Glioblastoma

Condition:   Glioblastoma
Interventions:   Radiation: Intensity Modulated Radiation Therapy;   Drug: Temozolomide;   Device: Three Dimensional Volumetric MRS Imaging;   Behavioral: FACT-BR Questionnaire;   Radiation: Stereotactic Radiosurgery Boost;   Radiation: Simultaneous Integrated Boost;   Device: MRI
Sponsor:   University of Miami
Recruiting - verified August 2015

Efficacy and Safety of Riociguat in Patients With Systemic Sclerosis

Condition:   Scleroderma, Systemic
Interventions:   Drug: Riociguat (Adempas, BAY63-2521);   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified August 2015

ATP in Alzheimer Disease

Condition:   Alzheimer's Disease
Interventions:   Drug: ADENOSINE TRIPHOSPHATE;   Drug: PLACEBO
Sponsor:   Sara Varea
Recruiting - verified August 2015

Ledipasvir/Sofosbuvir Fixed-Dose Combination on Cerebral Metabolism and Neurocognition in Treatment-Naive and Treatment-Experienced Participants With Chronic Genotype 1 HCV Infection

Condition:   Hepatitis C Virus Infection
Interventions:   Drug: LDV/SOF;   Drug: Placebo to match LDV/SOF
Sponsor:   Gilead Sciences
Active, not recruiting - verified August 2015

A Study of the Efficacy and Safety of Activase (Alteplase) in Patients With Mild Stroke (PRISMS)

Condition:   Brain Ischemia
Interventions:   Drug: alteplase [Activase];   Drug: alteplase placebo;   Drug: aspirin;   Drug: aspirin placebo
Sponsor:   Genentech, Inc.
Recruiting - verified August 2015

Treatment of Hepatic Encephalopathy With Flumazenil and Change in Cortical GABA Levels in MRS

Conditions:   Hepatic Encephalopathy;   Liver Cirrhosis
Interventions:   Drug: Flumazenil;   Drug: Placebo
Sponsor:   Yale University
Recruiting - verified August 2015

Pilot Study Efficacy and Tolerance Fish Oil Emulsion Daunorubicin and Cytarabine Treatment of AML Younger Patients

Condition:   Acute Myeloid Leukemia (AML)
Interventions:   Drug: OMEGAVEN;   Drug: Daunorubicin;   Drug: Cytarabine
Sponsors:   Groupe Ouest Est d'Etude des Leucémies et Autres Maladies du Sang GOELAMS;   Fresenius Kabi
Recruiting - verified August 2015

Development of Novel Therapies for NIDDM

Condition:   Metabolism
Interventions:   Other: 3 Tesla;   Other: 7 Tesla
Sponsors:   Duke University;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   University of Texas Southwestern Medical Center
Recruiting - verified August 2015

JAK2 Inhibitors RUXOLITINIB in Patients With Myelofibrosis

Condition:   Myelofibrosis
Intervention:   Drug: Ruxolotinib
Sponsor:   Groupe Ouest Est d'Etude des Leucémies et Autres Maladies du Sang GOELAMS
Recruiting - verified August 2015

A Study to Evaluate the Effect of Aleglitazar on Cardiac Energetics and Function in Patients With Type 2 Diabetes Mellitus and no History of Coronary Artery Disease

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: aleglitazar;   Drug: placebo
Sponsor:   Hoffmann-La Roche
Completed - verified August 2015

DaTSCAN Imaging in Aging and Neurodegenerative Disease

Conditions:   Dementia;   Parkinsonism;   Mild Cognitive Impairment;   REM Sleep Behavior Disorder
Interventions:   Drug: I-123 Ioflupane solution injection prior to SPECT scan (DaTscan);   Device: Single photon emission computed tomography (SPECT) scan
Sponsor:   Mayo Clinic
Enrolling by invitation - verified August 2015

Prospective, Randomised Study: Metabolic and Functional Effects of Bariatric Surgery Accessed Using Positron Emission Tomography (PET) and MRI.

Condition:   Morbid Obesity
Intervention:   Procedure: Bariatric surgery
Sponsor:   Turku University Hospital
Recruiting - verified May 2015

CArdiac Desynchronization In Obstructive HCM, CARDIO-HCM

Condition:   Hypertrophic Obstructive Cardiomyopathy (HOCM)
Interventions:   Device: Biventricular pacing;   Device: No Pacing
Sponsor:   Hospital Clinic of Barcelona
Recruiting - verified August 2015

A Study of RO5093151 in Patients With Non-Alcoholic Fatty Liver Disease

Condition:   Fatty Liver, Non-alcoholic Fatty Liver Disease, NAFLD
Interventions:   Drug: Placebo;   Drug: RO5093151
Sponsor:   Hoffmann-La Roche
Completed - verified August 2015

A Pilot Clinical Trial of Exendin-4 in Alzheimer's Disease

Conditions:   Alzheimer's Disease;   Mild Cognitive Impairment
Intervention:   Drug: Exendin-4 (Exenatide)
Sponsor:   National Institute on Aging (NIA)
Recruiting - verified August 2014

Efficacy and Safety of Asenapine Treatment for Pediatric Bipolar Disorder (P06107 Has an Extension [P05898; NCT01349907])(P06107)

Condition:   Bipolar Disorder, Pediatric
Interventions:   Drug: asenapine;   Drug: Placebo to match asenapine;   Drug: Rescue medication
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified August 2015

Efficacy and Safety Study of GM602 in Patients With Acute Middle Cerebral Artery Ischemic Stroke Within 18 Hours

Condition:   Stroke
Interventions:   Drug: GM602;   Drug: Matching Placebo (Bacteriostatic Saline) for GM602
Sponsors:   Genervon Biopharmaceuticals, LLC;   University of California, Los Angeles;   Huntington Hospital;   Hoag Memorial Hospital Presbyterian;   Columbia University;   California Pacific Medical Center Research Institute;   University Hospital Erlangen;   Sarasota Memorial Hospital;   University of Louisville
Recruiting - verified August 2015

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