High Cholesterol

Clinical Trial Finder

Many patients with high cholesterol are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Effects of Lomitapide on Carotid and Aortic Atherosclerosis

Condition:   Homozygous Familial Hypercholesterolemia
Intervention:   Drug: Lomitapide
Sponsor:   Aegerion Pharmaceuticals, Inc.
Not yet recruiting - verified March 2015

Atorvastatin Study in Cardiovascular Disease Risk

Conditions:   Hypercholesterolemia;   Dyslipidemia
Intervention:  
Sponsor:   Elpen Pharmaceutical Co. Inc.
Not yet recruiting - verified March 2015

A Study of Evacetrapib (LY2484595) in Combination With Atorvastatin in Japanese Participants With Primary Hypercholesterolemia

Condition:   Hypercholesterolemia
Interventions:   Drug: Evacetrapib;   Drug: Ezetimibe;   Drug: Atorvastatin;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Recruiting - verified March 2015

Extension (OLE) Study to Assess Safety and Efficacy of Evolocumab

Condition:   Hypercholesterolemia
Intervention:   Biological: Evolocumab
Sponsor:   Amgen
Enrolling by invitation - verified March 2015

A Study of Evacetrapib (LY2484595) in Participants With High Cholesterol

Condition:   Hyperlipidemia
Interventions:   Drug: Evacetrapib;   Drug: Atorvastatin;   Drug: Ezetimibe;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Recruiting - verified March 2015

CEntralized Pan-Russian Survey of tHE Undertreatment of hypercholeSterolemia II (CEPHEUS II)

Condition:   Dyslipidaemia
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified March 2015

Efficacy and Safety of Lomitapide in Japanese Patients With HoFH on Concurrent Lipid-Lowering Therapy

Condition:   Familial Hypercholesterolemia - Homozygous
Intervention:   Drug: lomitapide
Sponsor:   Aegerion Pharmaceuticals, Inc.
Active, not recruiting - verified June 2014

Safety Study of AEM-28 to Treat Refractory Hypercholesterolemia

Conditions:   Hypercholesterolemia;   Hyperlipoproteinemia Type II
Interventions:   Drug: AEM-28;   Drug: Normal Saline
Sponsor:   LipimetiX Development, LLC
Completed - verified March 2015

Replacement of Saturated Fat in Dairy on Total Cholesterol

Condition:   Hypercholesterolemia
Interventions:   Dietary Supplement: MUFA-rich dairy products (UHT milk, cheese and butter);   Dietary Supplement: Conventional dairy products (UHT milk, cheese, butter)
Sponsors:   University of Reading;   Medical Research Council
Recruiting - verified March 2015

Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects-3

Condition:   Hyperlipidemia
Interventions:   Drug: Part A, Atorvastatin;   Other: Part A, Placebo (administered orally);   Drug: Part B, Evolocumab;   Other: Part B, Placebo (administered orally);   Drug: Part B, Ezetimibe;   Other: Part B, Placebo (administered subcutaneously);   Drug: Part C, Evolocumab
Sponsor:   Amgen
Active, not recruiting - verified March 2015

A 52 Week Study To Assess The Use Of Bococizumab (PF-04950615; RN316) In Subjects With Heterozygous Familial Hypercholesterolemia

Condition:   Heterozygous Familial Hypercholesterolemia
Interventions:   Drug: Bococizumab (PF-04950615;RN316);   Other: Placebo
Sponsor:   Pfizer
Active, not recruiting - verified March 2015

Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Hyperlipidemia or Mixed Dyslipidemia at Risk of Cardiovascular Events

Condition:   Hyperlipidemia
Interventions:   Drug: Bococizumab (PF-04950615; RN316);   Other: Placebo
Sponsor:   Pfizer
Recruiting - verified March 2015

Randomized Clinical Trial Of Bococizumab (PF-04950615; RN316) In Subjects With Hyperlipidemia Or Mixed Dyslipidemia At Risk Of Cardiovascular Events

Condition:   Hyperlipidemia
Interventions:   Drug: Bococizumab (PF-04950615;RN316);   Other: Placebo
Sponsor:   Pfizer
Active, not recruiting - verified March 2015

Actual Use Trial of Atorvastatin Calcium 10 mg

Condition:   Hypercholesterolemia
Intervention:   Drug: Atorvastatin calcium 10 mg
Sponsor:   Pfizer
Completed - verified March 2015

GLobal Assessment of Plaque reGression With a PCSK9 antibOdy as Measured by intraVascular Ultrasound

Condition:   Hypercholesterolemia
Interventions:   Biological: Evolocumab (AMG 145);   Other: Placebo
Sponsor:   Amgen
Active, not recruiting - verified March 2015

A Study of the Safety and Efficacy of Anacetrapib (MK-0859) When Added to Ongoing Statin Therapy (MK-0859-021)

Condition:   Hypercholesterolemia
Interventions:   Drug: Anacetrapib 100 mg;   Drug: Placebo for anacetrapib 100 mg;   Drug: Anacetrapib 25 mg;   Drug: Placebo for anacetrapib 25 mg
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified March 2015

Trial Assessing Long Term USe of PCSK9 Inhibition in Subjects With Genetic LDL Disorders

Condition:   Severe Familial Hypercholesterolemia
Interventions:   Biological: Evolocumab (AMG145);   Biological: Evolocumab (AMG145)
Sponsor:   Amgen
Recruiting - verified March 2015

Effect of HAART Vs. Statin Treatment on Endothelial Function and Inflammation/Coagulation

Condition:   HIV-1 Infection
Interventions:   Drug: Pravastatin sodium;   Drug: Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate;   Drug: Pravastatin sodium
Sponsors:   AIDS Clinical Trials Group;   National Institute of Allergy and Infectious Diseases (NIAID)
Withdrawn - verified March 2015

A Study to Evaluate 3 Different Dosing Regimens of Mipomersen Administered Via Subcutaneous Injections to Healthy Volunteers

Condition:   Healthy Volunteer
Interventions:   Drug: mipomersen;   Drug: Placebo
Sponsors:   Genzyme, a Sanofi Company;   Isis Pharmaceuticals
Completed - verified March 2015

Long Term, Follow-on Study of Lomitapide in Patients With Homozygous Familial Hypercholesterolemia

Condition:   Familial Hypercholesterolemia
Intervention:   Drug: lomitapide
Sponsor:   Aegerion Pharmaceuticals, Inc.
Completed - verified March 2015

hsCRP in Japan Statin Treatment Against Recurrent Stroke (J-STARS hsCRP)

Condition:   Ischemic Stroke
Intervention:   Drug: Statin
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Ministry of Health, Labour and Welfare, Japan;   Hiroshima University;   Osaka University
Active, not recruiting - verified March 2015

Carotid Intima-media Thickness in Japan Statin Treatment Against Recurrent Stroke(J-STARS Echo)

Condition:   Ischemic Stroke
Intervention:   Drug: Statin
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Ministry of Health, Labour and Welfare, Japan;   Hiroshima University;   National Cerebral and Cardiovascular Center
Active, not recruiting - verified March 2015

Japan Statin Treatment Against Recurrent Stroke (J-STARS)

Condition:   Ischemic Stroke
Intervention:   Drug: Pravastatin
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Ministry of Health, Labour and Welfare, Japan;   Hiroshima University
Active, not recruiting - verified March 2015

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