High Cholesterol

Clinical Trial Finder

Many patients with high cholesterol are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk

Conditions:   Hypercholesterolemia;   Atherosclerotic Cardiovascular Diseases
Interventions:   Drug: ETC-1002;   Drug: Placebo
Sponsor:   Esperion Therapeutics
Recruiting - verified January 2016

Measuring the Impact of Dietary Supplementation With a New Baking Product on Gut Microbiota and Cholesterol Metabolism

Condition:   Hypercholesterolemia
Interventions:   Dietary Supplement: PreBIOil;   Dietary Supplement: Control
Sponsors:   Fondazione Edmund Mach;   Casa di Cura Eremo di Arco (TN) Italy;   OlioCRU Consorzio srl Arco (TN) Italy
Recruiting - verified January 2016

Pharmacokinetic and Pharmacodynamic Study of Bococizumab Alone and When Combined With Recombinant Human Hyaluronidase

Conditions:   Hypercholesterolemia;   Healthy
Interventions:   Biological: Cohort 1: bococizumab 150 mg + rHuPH20;   Biological: Cohort 2: bococizumab 300 mg;   Biological: Cohort 3: bococizumab 300 mg + rHuPH20;   Biological: Cohort 4: bococizumab 300 mg + rHuPH20;   Biological: Cohort 5: bococizumab 450 mg + rHuPH20
Sponsors:   Pfizer;   Halozyme Therapeutics
Not yet recruiting - verified January 2016

Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects-4

Condition:   Hypercholesterolemia
Interventions:   Biological: Evolocumab;   Drug: Ezetimibe;   Biological: Evolocumab;   Drug: Ezetimibe
Sponsors:   Amgen;   Data Monitoring Committee (DMC)
Not yet recruiting - verified February 2016

Single Dose Study of PF-06815345 in Healthy Subjects

Condition:   Hypercholesterolemia
Interventions:   Drug: PF-06815345;   Other: Placebo;   Drug: PF-06815345
Sponsor:   Pfizer
Recruiting - verified February 2016

Efficacy and Safety of Alirocumab in Patients With Hypercholesterolemia Not Adequately Controlled With Non-statin Lipid Modifying Therapy or the Lowest Strength of Statin

Condition:   Hypercholesterolaemia
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Drug: placebo;   Drug: atorvastatin;   Drug: fenofibrate;   Drug: bezafibrate;   Drug: ezetimibe
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified February 2016

Study Assessing Safety, Immunogenicity and LDLc -Lowering Activity of 2 PCSK9 Targeting AFFITOPE Vaccines in Healthy Subjects

Condition:   Hypercholesterolemia
Interventions:   Biological: AFFITOPE® AT04A+adjuvant;   Biological: AFFITOPE® AT06A+adjuvant;   Biological: Adjuvant without active component
Sponsors:   Affiris AG;   Medical University of Vienna
Active, not recruiting - verified February 2016

Clinical Trial to Evaluate the Efficacy and Safety of CKD-391

Condition:   Hyperlipidemia
Interventions:   Drug: Atorvastatin10mg, Ezetimibe10mg;   Drug: Atorvastatin10mg, Ezetimibe placebo;   Drug: Atorvastatin20mg, Ezetimibe10mg;   Drug: Atorvastatin20mg, Ezetimibe placebo;   Drug: Atorvastatin40mg, Ezetimibe10mg;   Drug: Atorvastatin40mg, Ezetimibe placebo
Sponsor:   Chong Kun Dang Pharmaceutical
Completed - verified January 2016

Efficacy, Safety, Tolerability And Actual Use Study Of Bococizumab And An Autoinjector (Pre-Filled Pen) In Subjects With Hyperlipidemia Or Dyslipidemia

Condition:   Hyperlipidemia
Interventions:   Biological: Bococizumab 150mg;   Biological: Bococizumab 75mg;   Biological: Bococizumab 150mg placebo;   Biological: Bococizumab 75mg placebo
Sponsor:   Pfizer
Active, not recruiting - verified February 2016

Extension (OLE) Study to Assess Safety and Efficacy of Evolocumab

Condition:   Hypercholesterolemia
Intervention:   Biological: Evolocumab
Sponsor:   Amgen
Enrolling by invitation - verified February 2016

Peripheral Arterial Insufficiency Associated With HIV/AIDS

Conditions:   Arterial Insufficiency;   Acquired Immunodeficiency Syndrome;   HIV
Intervention:   Procedure: Ankle-Brachial index
Sponsor:   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Completed - verified January 2016

Hypertriglyceridaemia - Cause and Effects

Condition:   Hypertriglyceridaemia
Intervention:  
Sponsor:   Central Manchester University Hospitals NHS Foundation Trust
Recruiting - verified January 2016

Use of Decision Aids in Clinical Encounters

Condition:   Diabetes, Depression, Cardiovascular Disease,Hypercholesterolemia, Osteoporosis
Interventions:   Other: Active Implementation of ShareEBM Toolkit;   Other: Passive Dissemination of Share EBM
Sponsor:   Mayo Clinic
Enrolling by invitation - verified February 2016

Replacement of Saturated Fat in Dairy on Total Cholesterol

Condition:   Hypercholesterolemia
Interventions:   Dietary Supplement: MUFA-rich dairy products (UHT milk, cheese and butter);   Dietary Supplement: Conventional dairy products (UHT milk, cheese, butter)
Sponsors:   University of Reading;   Medical Research Council
Active, not recruiting - verified February 2016

Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer

Conditions:   Breast Cancer;   Breast Tumors;   Cancer of Breast
Interventions:   Drug: Metformin;   Drug: Atorvastatin;   Procedure: Breast surgery
Sponsor:   Columbia University
Recruiting - verified February 2016

A 52 Week Study To Assess The Use Of Bococizumab (PF-04950615; RN316) In Subjects With Heterozygous Familial Hypercholesterolemia

Condition:   Heterozygous Familial Hypercholesterolemia
Interventions:   Drug: Bococizumab (PF-04950615;RN316);   Other: Placebo
Sponsor:   Pfizer
Active, not recruiting - verified February 2016

Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Hyperlipidemia or Mixed Dyslipidemia at Risk of Cardiovascular Events

Condition:   Hyperlipidemia
Interventions:   Drug: Bococizumab (PF-04950615; RN316);   Other: Placebo
Sponsor:   Pfizer
Recruiting - verified January 2016

Randomized Clinical Trial Of Bococizumab (PF-04950615; RN316) In Subjects With Hyperlipidemia Or Mixed Dyslipidemia At Risk Of Cardiovascular Events

Condition:   Hyperlipidemia
Interventions:   Drug: Bococizumab (PF-04950615;RN316);   Other: Placebo
Sponsor:   Pfizer
Active, not recruiting - verified February 2016

Effect of Plant Sterol Enriched Milk on Plasma Lipid Levels of Humans Breast-fed During Infancy

Conditions:   Hypercholesterolemia;   CVD
Interventions:   Other: Plant Sterols;   Other: High cholesterol;   Other: Placebo
Sponsor:   University of Manitoba
Active, not recruiting - verified March 2013

Effect of HAART Vs. Statin Treatment on Endothelial Function and Inflammation/Coagulation

Condition:   HIV-1 Infection
Interventions:   Drug: Pravastatin sodium;   Drug: Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate;   Drug: Pravastatin sodium
Sponsors:   AIDS Clinical Trials Group;   National Institute of Allergy and Infectious Diseases (NIAID)
Withdrawn - verified January 2016

Open Label Study of Long Term Evaluation Against LDL-C Trial

Condition:   Hypercholesterolemia
Interventions:   Biological: Evolocumab (AMG 145) and standard of care;   Other: Standard of care
Sponsor:   Amgen
Active, not recruiting - verified January 2016

Abdominal Obesity and Cardiovascular Risk Factors in Women Who Survived Cancer or a Related Illness Following Total Body Irradiation and Stem Cell Transplant

Conditions:   Leukemia;   Hodgkin's Lymphoma;   Non-Hodgkin's Lymphoma;   Myelodysplastic Syndrome
Intervention:   Other: Questionnaires, Laboratory tests, Abdominal MRI
Sponsors:   Memorial Sloan Kettering Cancer Center;   Queen's University, Kingston, Ontario;   Weill Medical College of Cornell University
Active, not recruiting - verified February 2016

Postprandial Lipemia and Endothelial Function in ACCORD- Ancillary to ACCORD

Conditions:   Atherosclerosis;   Cardiovascular Diseases;   Hypercholesterolemia;   Heart Diseases
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008