High Cholesterol

Clinical Trial Finder

Many patients with high cholesterol are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Study of Awareness and Detection of Familial Hypercholesterolemia

Condition:   Hypercholesterolemia
Intervention:  
Sponsors:   The Familial Hypercholesterolemia Foundation;   Duke Clinical Research Institute
Recruiting

Safety and Efficacy of Evolocumab in Addition to Optimal Stable Background Statin Therapy in Chinese Subjects With Primary Hypercholesterolemia and Mixed Dyslipidemia

Conditions:   Primary Hypercholesterolemia;   Mixed Dyslipidemia
Interventions:   Drug: Evolocumab 140 mg SC Q2W;   Drug: Evolocumab 420 mg SC QM;   Other: Placebo SC Q2W;   Other: Placebo SC QM
Sponsor:   Amgen
Recruiting

A Research Study Investigating How NNC0385-0434 is Tolerated in People With or Without High Cholesterol Levels

Conditions:   Healthy Volunteers;   Hypercholesterolaemia
Interventions:   Drug: NNC0385-0434;   Drug: Placebo (NNC0385-0434)
Sponsor:   Novo Nordisk A/S
Recruiting

An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia

Condition:   Hypercholesterolaemia
Interventions:   Drug: Alirocumab SAR236553 (REGN727);   Drug: Rosuvastatin;   Drug: Atorvastatin;   Drug: Simvastatin;   Drug: Pravastatin;   Drug: Lovastatin;   Drug: Fluvastatin;   Drug: Ezetimibe;   Drug: Cholestyramine;   Drug: Nicotinic acid;   Drug: Fenofibrate;   Drug: Omega-3 fatty acids;   Drug: Placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting

Effect of Dietary Intervention on LDL-C and Lipoprotein Subclasses Distribution in Patients With Hypercholesterolemia

Conditions:   Hypercholesterolemia;   Disease;   Dyslipidemias
Interventions:   Dietary Supplement: Placebo;   Dietary Supplement: Dietary portfolio
Sponsor:   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Completed

Evaluating the Efficacy and Safety of Co-administrated Rosuvastatin/Ezetimibe and Telmisartan/Amlodipine

Conditions:   Hypercholesterolemia;   Hypertension
Interventions:   Drug: Ezetimibe/Rosuvastatin;   Drug: Telmisartan;   Drug: Telmisartan/Amlodipine 80 Mg-5 Mg ORAL TABLET
Sponsor:   Addpharma Inc.
Not yet recruiting

Chart Review of Repatha® in Subjects With Hyperlipidaemia

Condition:   Hypercholesterolaemia
Intervention:  
Sponsor:   Amgen
Recruiting

A Study to Evaluate the Safety and Efficacy of the PCSK9 Inhibitor AK102 in Patients With HoFH

Condition:   Homozygous Familial Hypercholesterolemia
Interventions:   Drug: AK102;   Drug: Statins;   Drug: Ezetimibe
Sponsors:   Akeso;   AD Pharmaceuticals Co., Ltd. (Guangzhou)
Recruiting

Phase 3 Study to Evaluate the Efficacy and Safety of LIB003 With Evolocumab in HoFH

Condition:   Homozygous Familial Hypercholesterolemia
Interventions:   Drug: LIB003;   Drug: evolocumab
Sponsor:   LIB Therapeutics LLC
Enrolling by invitation

Phase 2a Study to Assess CIVI 007 in Patients on a Background of Statin Therapy

Condition:   Hypercholesterolemia
Intervention:   Drug: CIVI 007
Sponsor:   Civi Biopharma, Inc.
Not yet recruiting

A Study of PCSK9 Inhibitor AK102 in Healthy Subjects

Condition:   Hypercholesterolaemia
Interventions:   Drug: AK102;   Drug: Placebo
Sponsors:   Akeso;   AD Pharmaceuticals Co., Ltd. (Guangzhou)
Completed

Open-Label Extension to Evaluate the Longer Term Efficacy and Safety of LIB003

Condition:   Hypercholesterolemia
Intervention:   Drug: LIB003
Sponsor:   LIB Therapeutics LLC
Active, not recruiting

Ezetimibe (EZ)/Atorvastatin (Ator) (MK-0653C) vs. Ator in Chinese Hypercholesterolemic Participants (MK-0653C-439)

Condition:   Hypercholesterolemia
Interventions:   Combination Product: EZ 10 mg/Ator 10 mg;   Combination Product: EZ 10 mg/Ator 20 mg;   Drug: Atorvastatin;   Drug: Placebo for FDC EZ/Ator;   Drug: Placebo for atorvastatin
Sponsor:   Merck Sharp & Dohme Corp.
Recruiting

Plant Sterol INtervention for Cancer Prevention (PINC)

Conditions:   Hypercholesterolemia;   Breast Cancer;   Obesity
Interventions:   Dietary Supplement: Cholesterol Reducing Strawberry Yogurt Drink (Tesco Ltd);   Dietary Supplement: Low Fat Strawberry Yogurt Drinks (Morrisons Ltd)
Sponsors:   University of Leeds;   The Leeds Teaching Hospitals NHS Trust;   University of Oslo
Not yet recruiting

Return of First-phase Insulin Secretion in Type 2 Diabetes is Associated With Depletion of Pancreas Lipid

Condition:   Type 2 Diabetes Mellitus
Interventions:   Other: Low Glycemic Diet;   Other: Control Diet
Sponsor:   University of Alabama at Birmingham
Recruiting

Supplementation of Oil Palm Phenolics to Healthy Participants

Conditions:   Cardiovascular Diseases;   Hyperlipidemias;   Hypercholesterolemia
Interventions:   Drug: Placebos;   Dietary Supplement: Oil Palm Phenolics
Sponsors:   National University of Malaysia;   Malaysia Palm Oil Board
Not yet recruiting

Genetics of Obesity, Diabetes, and Heart Disease in African Diaspora Populations

Conditions:   Diabetes;   Cardiovascular Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Enrolling by invitation

Impact of Statin Therapy on Adaptations to Aerobic Exercise

Condition:   Cardiovascular Diseases
Interventions:   Drug: Lipitor 20Mg Tablet;   Drug: Lipitor 80Mg Tablet;   Drug: Placebo;   Behavioral: Exercise Program
Sponsors:   University of Kansas Medical Center;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting

Treatment for Non-Alcoholic Fatty Liver With Different Doses of Vitamin E

Condition:   Fatty Liver
Interventions:   Drug: Vitamin E 200 IU/d;   Drug: Vitamin E 400 IU/d;   Drug: Vitamin E 800 IU/d;   Behavioral: Diet and Exercise
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins

Conditions:   Hypolipoproteinemia;   Hypercholesterolemia;   Dyslipidemia;   Hyperlipidemia
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome

Conditions:   Cancer;   Skin Fibroblasts;   Muscle Weakness
Intervention:   Dietary Supplement: Niagen
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Arts & Health Education to Improve Health, Resilience, and Well-Being

Conditions:   Hypertension;   Diabetes;   Obesity;   COPD;   CHF;   High Cholesterol;   Asthma;   Chronic Pain;   Multiple Sclerosis;   Depression;   Anxiety;   Heart Diseases;   Stroke
Interventions:   Behavioral: HeRe We Arts;   Behavioral: HeRe We Ed
Sponsors:   The Cleveland Clinic;   National Endowment for the Arts;   Cuyahoga Arts and Culture
Recruiting

A Study of People With Type 2 Diabetes Who Have Diseases That Affect the Heart and Blood Vessels. The Study Will Also Look at the Treatment of a Group of These People in Hospitals in Portugal

Condition:   Diabetes Mellitus, Type 2
Intervention:   Other: No treatment given
Sponsor:   Novo Nordisk A/S
Completed

DISCOVER Global Registry

Condition:   Type 2 Diabetes
Intervention:  
Sponsor:   AstraZeneca
Recruiting