High Cholesterol

Clinical Trial Finder

Many patients with high cholesterol are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Alirocumab in Patients With Acute Myocardial Infarction

Conditions:   Myocardial Infarction;   Hypercholesterolemia
Interventions:   Drug: alirocumab;   Drug: placebo
Sponsors:   Virginia Commonwealth University;   Regeneron Pharmaceuticals;   Sanofi
Not yet recruiting - verified October 2016

Evaluate the Pharmacokinetics and Safety of HCP1306 and Co-administration of HGP0816, HGP1404 in Healthy Male Volunteers

Condition:   Primary Hypercholesterolemia
Interventions:   Drug: HGP0816;   Drug: HGP1404;   Drug: HCP1306
Sponsor:   Hanmi Pharmaceutical Company Limited
Completed - verified January 2015

Safety and Tolerability of VK2809 in Patients With Primary Hypercholesterolemia and Non-Alcoholic Fatty Liver Disease

Conditions:   Hyperlipidemia;   NAFLD
Interventions:   Drug: VK2809;   Drug: Placebo
Sponsor:   Viking Therapeutics, Inc.
Recruiting - verified October 2016

Analysis of Sympathetic Activity in Willis-Ekbom Disease

Conditions:   Willis-Ekbom Disease;   Restless Legs Syndrome
Intervention:   Other: Sympathetic nervous activity measurement
Sponsor:   University Hospital, Montpellier
Not yet recruiting - verified October 2016

An 8-Week Dose-Finding Study to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia

Condition:   Hypercholesterolaemia
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Drug: statins;   Drug: ezetimibe;   Drug: cholestyramine;   Drug: fenofibrate;   Drug: omega-3 fatty acids;   Drug: nicotinic acid
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified October 2016

A Study in Subjects With Type 2 Diabetes Mellitus With Hypercholesterolemia/Mixed Dyslipidemia

Conditions:   Hypercholesterolemia;   Mixed Dyslipidemia;   Type 2 Diabetes
Interventions:   Biological: Evolocumab;   Other: Placebo to Evolocumab
Sponsor:   Amgen
Recruiting - verified October 2016

A Study of the Efficacy and Safety of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-832)

Condition:   Hypercholesterolemia
Interventions:   Drug: Ezetimibe 10 mg;   Drug: Rosuvastatin 2.5 mg;   Drug: Placebo for Ezetimibe;   Drug: Placebo for Rosuvastatin
Sponsor:   Merck Sharp & Dohme Corp.
Active, not recruiting - verified October 2016

Graves' Orbitopathy and Hypercholesterolemia

Conditions:   Graves' Ophthalmopathy;   Hypercholesterolemia
Intervention:   Other: No intervention
Sponsor:   University of Pisa
Completed - verified October 2016

Point-of-Care Adipose-derived Cells for Hair Growth

Condition:   Androgenetic Alopecia
Interventions:   Procedure: Stromal Vascular Fraction Cells (SVF Cells) Injection;   Procedure: Liposuction;   Other: Hair Measurements
Sponsor:   University of Florida
Recruiting - verified October 2016

Efficacy of a LRC™ (L. Reuteri NCIMB 30242) Capsule on Managing Cholesterol in Adults

Condition:   Hypercholesterolemia
Interventions:   Dietary Supplement: LRC™ capsule;   Other: Placebo capsule
Sponsor:   UAS Labs LLC
Recruiting - verified October 2016

Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With Hypercholesterolemia

Condition:   Hypercholesterolemia
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Drug: placebo for alirocumab;   Drug: ezetimibe;   Drug: placebo for ezetimibe;   Drug: atorvastatin;   Drug: rosuvastatin;   Drug: simvastatin
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified October 2016

Pharmacokinetic and Pharmacodynamic Study of Bococizumab Alone and When Combined With Recombinant Human Hyaluronidase

Conditions:   Healthy;   Hypercholesterolemia
Interventions:   Biological: Cohort 1: bococizumab 150 mg + rHuPH20;   Biological: Cohort 2: bococizumab 300 mg;   Biological: Cohort 3: bococizumab 300 mg + rHuPH20;   Biological: Cohort 5: bococizumab 450 mg + rHuPH20;   Biological: Cohort 4: bococizumab 300 mg + rHuPH20
Sponsors:   Pfizer;   Halozyme Therapeutics
Terminated - verified October 2016

A 12-Week, Phase 2 Study Patients With Severe Hypercholesterolemia

Condition:   Hypercholesteremia
Interventions:   Drug: Gemcabene 600 mg;   Drug: Placebo
Sponsor:   Gemphire Therapeutics, Inc.
Not yet recruiting - verified October 2016

Atorvastatin Effectiveness and Safety in Cardiology Patients in Real World Setting

Condition:   Coronary Artery Disease, Hypercholesterolemia, Hypertension
Intervention:   Other: No intervention
Sponsor:   Pfizer
Active, not recruiting - verified October 2016

Acute and Long-term Cardiovascular Toxicity After Modern Radiotherapy for Breast Cancer

Conditions:   Breast Neoplasms;   Cardiovascular Diseases
Sponsors:   St. Olavs Hospital;   Norwegian University of Science and Technology;   Alesund Hospital
Not yet recruiting - verified October 2016

Study Evaluating Novel Biomarkers of AKI (Acute Kidney Injury) in Post-operative Patients

Conditions:   Acute Kidney Injury;   Arterial Hypertension;   Obesity;   Cardio Vascular Disease;   Diabetes Mellitus;   Chronic Liver Disease;   Hypercholesterolemia
Interventions:   Device: Nephro Check Test;   Other: serum creatinine measurement
Sponsor:   Universitair Ziekenhuis Brussel
Recruiting - verified October 2016

Relationship Between Insulin Resistance and Statin Induced Type 2 Diabetes, and Integrative Personal Omics Profiling

Condition:   Hyperlipidemia
Intervention:   Drug: Atorvastatin
Sponsor:   Stanford University
Recruiting - verified October 2016

Trial Assessing Efficacy, Safety and Tolerability of PCSK9 Inhibition in Paediatric Subjects With Genetic LDL Disorders

Condition:   Heterozygous Familial Hypercholesterolemia
Interventions:   Drug: Evolocumab;   Drug: Placebo
Sponsor:   Amgen
Recruiting - verified October 2016

Genetically Guided Statin Therapy

Conditions:   Hypercholesterolemia;   HMG COA Reductase Inhibitor Adverse Reaction
Interventions:   Genetic: Reporting for SLCO1B1*5 allele at randomization;   Genetic: Reporting for SLCO1B1*5 allele at the end;   Genetic: Genetic testing for SLCO1B1*5 allele
Sponsors:   Duke University;   David Grant U.S. Air Force Medical Center
Completed - verified October 2016

Pilot Program to Improve Statin Adherence and Lower Cholesterol in Older Adults

Conditions:   Hypercholesterolemia;   Medication Adherence
Interventions:   Behavioral: Medication adherence intervention;   Behavioral: Attention-control
Sponsor:   University of Missouri-Columbia
Completed - verified October 2016

Study of A3309 in Patients With Dyslipidemia

Condition:   Dyslipidemia
Interventions:   Drug: A3309;   Drug: A3309;   Drug: Placebo
Sponsor:   Albireo
Completed - verified October 2016

Cardiac Magnetic Resonance Imaging (MRI) Normal Reference Control Group Testing

Condition:   Healthy
Intervention:   Other: Cardiac MRI
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified October 2016