High Cholesterol

Clinical Trial Finder

Many patients with high cholesterol are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Atherosclerosis in Familial Hypercholesterolemia

Condition:   Familial Hypercholesterolemia
Intervention:   Other: CT coronary angiogram and carotid ultrasound
Sponsor:   University College, London
Recruiting - verified July 2015

Safety, Tolerability, and Effect of Alirocumab in High Cardiovascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With Conventional Lipid-modifying Therapies

Condition:   Hypercholesterolemia
Interventions:   Drug: ALIROCUMAB SAR236553 (REGN727);   Drug: placebo (for injection training only)
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified June 2015

The Combined Portfolio Diet and Exercise Study

Conditions:   Cardiovascular Diseases;   Hypercholesterolemia;   Type 2 Diabetes;   Metabolic Syndrome
Interventions:   Behavioral: Portfolio Plus Diet;   Behavioral: DASH-like (high fiber) Diet
Sponsors:   St. Michael's Hospital, Toronto;   Canadian Institutes of Health Research  (CIHR);   University of Toronto;   Laval University;   University of Manitoba;   University of British Columbia
Not yet recruiting - verified June 2015

Efficacy, Safety, Tolerability And Actual Use Study Of Bococizumab And An Autoinjector (Pre-Filled Pen) In Subjects With Hyperlipidemia Or Dyslipidemia

Condition:   Hyperlipidemia
Interventions:   Biological: Bococizumab 150mg;   Biological: Bococizumab 75mg;   Biological: Bococizumab 150mg placebo;   Biological: Bococizumab 75mg placebo
Sponsor:   Pfizer
Recruiting - verified June 2015

Trial Assessing Efficacy, Safety and Tolerability of PCSK9 Inhibition in Paediatric Subjects With Genetic LDL Disorders

Condition:   Heterozygous Familial Hypercholesterolemia
Interventions:   Drug: Evolocumab;   Drug: Placebo
Sponsor:   Amgen
Not yet recruiting - verified June 2015

Patient and Provider Assessment of Lipid Management Registry

Conditions:   Hyperlipidemia;   Hypercholesterolemia;   Cardiovascular Disease;   Diabetes;   Chronic Kidney Disease (CKD);   Hypertension;   Smoking;   Myocardial Infarction (MI);   Unstable Angina;   Angina;   Coronary Artery Disease (CAD);   Stroke;   Transient Ischemic Attack (TIA);   Carotid Stenosis;   Peripheral Arterial Disease;   Atherosclerosis;   Claudication
Intervention:  
Sponsors:   Duke University;   Regeneron Pharmaceuticals;   Sanofi
Recruiting - verified June 2015

A Study of Evacetrapib (LY2484595) in Participants With High Cholesterol

Condition:   Hyperlipidemia
Interventions:   Drug: Evacetrapib;   Drug: Atorvastatin;   Drug: Ezetimibe;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Recruiting - verified June 2015

CEntralized Pan-Russian Survey of tHE Undertreatment of hypercholeSterolemia II (CEPHEUS II)

Condition:   Dyslipidaemia
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified June 2015

Evaluating PCSK9 Binding antiBody Influence oN coGnitive HeAlth in High cardiovascUlar Risk Subjects

Condition:   Dyslipidemia
Interventions:   Biological: Evolocumab (AMG 145);   Other: Placebo;   Drug: Effective statin therapy
Sponsor:   Amgen
Recruiting - verified June 2015

Open Label Study of Long Term Safety Evaluation of Alirocumab

Condition:   Hypercholesterolemia
Intervention:   Drug: Alirocumab SAR236553 (REGN727)
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified June 2015

Effects of Colesevelam

Condition:   Sitosterolemia
Interventions:   Drug: Colesevelam;   Other: Placebo
Sponsor:   University of Manitoba
Not yet recruiting - verified February 2015

A Study of the Safety and Efficacy of Anacetrapib (MK-0859) Among Participants With Hypercholesterolemia When Added to Ongoing Statin Therapy (MK-0859-022)

Condition:   Hypercholesterolemia
Interventions:   Drug: Anacetrapib;   Drug: Placebo
Sponsor:   Merck Sharp & Dohme Corp.
Active, not recruiting - verified June 2015

Open Label Study of Long Term Evaluation Against LDL-C Trial-2

Condition:   Hyperlipidemia and Mixed Dyslipidemia
Interventions:   Biological: evolocumab (AMG 145) and standard of care;   Other: Standard of care
Sponsor:   Amgen
Recruiting - verified June 2015

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk

Condition:   Dyslipidemia
Interventions:   Biological: Evolocumab (AMG 145);   Other: Placebo;   Drug: Effective statin therapy
Sponsor:   Amgen
Active, not recruiting - verified June 2015

Trial Assessing Long Term USe of PCSK9 Inhibition in Subjects With Genetic LDL Disorders

Condition:   Severe Familial Hypercholesterolemia
Interventions:   Biological: Evolocumab (AMG145);   Biological: Evolocumab (AMG145)
Sponsor:   Amgen
Active, not recruiting - verified June 2015

Open-Label Extension of Study R727-CL-1003 to Evaluate the Long-Term Safety and Efficacy of REGN727 (SAR236553) in Patients With Hypercholesterolemia

Condition:   Hypercholesterolemia
Intervention:   Drug: REGN727 (SAR236553)
Sponsors:   Regeneron Pharmaceuticals;   Sanofi
Active, not recruiting - verified June 2015

Study to Assess the Tolerability and Efficacy of Anacetrapib Co-administered With Statin in Participants With Heterozygous Familial Hypercholesterolemia (MK-0859-020)

Conditions:   Hyperlipoproteinemia Type II;   Heterozygous Familial Hypercholesterolemia
Interventions:   Drug: Anacetrapib;   Drug: Placebo for Anacetrapib
Sponsor:   Merck Sharp & Dohme Corp.
Active, not recruiting - verified June 2015

Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression

Conditions:   Atherosclerosis;   Hypercholesterolemia
Interventions:   Drug: Statin Drugs;   Other: HMG-CoA Reductase Inhibitors
Sponsor:   National Institutes of Health Clinical Center (CC)
Active, not recruiting - verified April 2015

Use of Simvastatin for the Prevention of Vasospasm in Aneurysmal Subarachnoid Hemorrhage

Conditions:   Aneurysmal Subarachnoid Hemorrhage;   Cerebral Vasospasm
Interventions:   Drug: Simvastatin;   Drug: Placebo
Sponsor:   University of Illinois at Chicago
Terminated - verified June 2015

Effectiveness of Nigella Sativa (Kalonji) Seed in Dyslipidemia

Conditions:   Hypercholesterolemia;   Hypertension;   Diabetes Mellitus;   Metabolic Syndrome X
Intervention:   Drug: Nigella sativa seed
Sponsor:   Aga Khan University
Completed - verified April 2007

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