High Cholesterol

Clinical Trial Finder

Many patients with high cholesterol are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Cardiovascular Health Promotion Among African-Americans by FAITH!

Conditions:   Cardiovascular Diseases;   Prevention;   Physical Activity;   Diet Modification;   Diabetes;   Hypertension;   High Cholesterol;   Pre Diabetes;   Smoking Cessation;   Obesity
Intervention:   Behavioral: FAITH! App digital intervention
Sponsors:   Mayo Clinic;   Mayo Clinic Clinic Center for Innovation;   Mayo Clinic Center for Clinical and Translational Science (CCaTS)
Active, not recruiting - verified March 2017

A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous (SC) Administered Alirocumab in Healthy Chinese Subjects

Condition:   Hypercholesterolemia
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Drug: placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified March 2017

Evaluating Effect of the Study Drug Praluent (Alirocumab) on Neurocognitive Function When Compared to Placebo

Condition:   Hypercholesterolemia
Interventions:   Drug: Praluent (Alirocumab);   Drug: Placebo
Sponsors:   Regeneron Pharmaceuticals;   Sanofi
Recruiting - verified March 2017

Study to Evaluate the Safety of Repatha® in Pregnancy

Conditions:   Hypercholesterolaemia;   Pregnancy
Intervention:  
Sponsor:   Amgen
Recruiting - verified March 2017

Chart Review of Repatha® in Subjects With Hyperlipidaemia

Condition:   Hypercholesterolaemia
Intervention:  
Sponsor:   Amgen
Recruiting - verified March 2017

Genetic Basis for Prediction of Non-responders to Dietary Plant Sterol Intervention

Conditions:   Hypercholesterolemia;   Cardiovascular Disease
Interventions:   Other: Plant sterols;   Other: Placebo
Sponsors:   University of Manitoba;   Mitacs;   Unilever R&D;   Nutritional Fundamentals for Health
Recruiting - verified March 2017

A Study in Subjects With Type 2 Diabetes Mellitus With Hypercholesterolemia/Mixed Dyslipidemia

Conditions:   Hypercholesterolemia;   Mixed Dyslipidemia;   Type 2 Diabetes
Interventions:   Biological: Evolocumab;   Other: Placebo to Evolocumab
Sponsor:   Amgen
Recruiting - verified March 2017

Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With Hypercholesterolemia

Condition:   Hypercholesterolemia
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Drug: placebo for alirocumab;   Drug: ezetimibe;   Drug: placebo for ezetimibe;   Drug: atorvastatin;   Drug: rosuvastatin;   Drug: simvastatin
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified March 2017

Trial of Antroquinonol in Patients With Hypercholesterolemia and Hyperlipidemia

Condition:   Hyperlipidemias
Interventions:   Drug: Antroquinonol;   Drug: placebo
Sponsor:   Golden Biotechnology Corporation
Recruiting - verified March 2017

Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk (CLEAR Harmony)

Conditions:   Hypercholesterolemia;   Atherosclerotic Cardiovascular Diseases
Interventions:   Drug: ETC-1002;   Drug: Placebo
Sponsor:   Esperion Therapeutics
Active, not recruiting - verified March 2017

A Gene Therapy Study for Homozygous Familial Hypercholesterolemia (HoFH)

Condition:   Homozygous Familial Hypercholesterolemia
Intervention:   Biological: AAV directed hLDLR gene therapy
Sponsor:   University of Pennsylvania
Recruiting - verified March 2017

Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects-4

Condition:   Hypercholesterolemia
Interventions:   Biological: Evolocumab;   Drug: Ezetimibe;   Biological: Evolocumab;   Drug: Ezetimibe
Sponsors:   Amgen;   Data Monitoring Committee (DMC)
Recruiting - verified March 2017

Atorvastatin Effectiveness and Safety in Cardiology Patients in Real World Setting

Condition:   Coronary Artery Disease, Hypercholesterolemia, Hypertension
Intervention:   Other: No intervention
Sponsor:   Pfizer
Recruiting - verified March 2017

Trial Assessing Efficacy, Safety and Tolerability of PCSK9 Inhibition in Paediatric Subjects With Genetic LDL Disorders

Condition:   Heterozygous Familial Hypercholesterolemia
Interventions:   Drug: Evolocumab;   Drug: Placebo
Sponsor:   Amgen
Recruiting - verified March 2017

Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery

Condition:   Preeclampsia
Intervention:   Device: Apheresis using Liposorber LA-15 System
Sponsors:   Massachusetts General Hospital;   Kaneka Pharma America LLC
Completed - verified March 2017

The Effects of Lowering Low-density Lipoprotein Cholesterol Levels to New Targets on Cardiovascular Complications in Peritoneal Dialysis Patients

Condition:   Hypercholesterolemia
Intervention:   Other: LDL-cholesterol
Sponsors:   Clinical Research Center for End Stage Renal Disease, Korea;   Ministry of Health & Welfare, Korea
Completed - verified October 2009

Cardiac Magnetic Resonance Imaging (MRI) Normal Reference Control Group Testing

Condition:   Healthy
Intervention:   Other: Cardiac MRI
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified March 2017

Ezetimibe (+) Simvastatin vs. Atorvastatin Comparative Study in DM or Metabolic Syndrome Patients (0653A-093)

Condition:   Hypercholesterolemia
Interventions:   Drug: simvastatin (+) ezetimibe;   Drug: atorvastatin
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified March 2017