High Cholesterol

Clinical Trial Finder

Many patients with high cholesterol are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Study in Participants ≥12 Years of Age With Homozygous Familial Hypercholesterolemia (hoFH)

Condition:   Homozygous Familial Hypercholesterolemia
Interventions:   Drug: Alirocumab;   Drug: Placebo
Sponsors:   Regeneron Pharmaceuticals;   Sanofi
Not yet recruiting - verified May 2017

A Registration Study for Familial Hypercholesterolemia in Taiwan

Condition:   Familial Hypercholesterolemia
Intervention:  
Sponsor:   National Taiwan University Hospital
Recruiting - verified September 2016

Greek Registry - Familial Hypercholesterolaemia

Condition:   Familial Hypercholesterolemia
Intervention:  
Sponsor:   Hellenic College of Treatment of Atherosclerosis
Recruiting - verified May 2017

Digital Ankle Brachial Index (ABI) as a Screening Tool in Detecting Peripheral Arterial Disease

Conditions:   Peripheral Artery Disease;   Amputation;   Smoking;   Diabetes;   Hypercholesterolemia;   Hypertension
Intervention:   Device: ABI using QuantaFlo™
Sponsor:   St. Louis University
Recruiting - verified May 2017

Pharmacist CVD Intervention for Patients With Inflammatory Arthritis

Conditions:   Inflammatory Arthritis;   Cardiovascular Risk Factor;   Rheumatoid Arthritis;   Ankylosing Spondylitis;   Psoriatic Arthritis
Intervention:   Other: CV risk assessment and modification of global risk
Sponsor:   Epidemiology Coordinating and Research Centre, Canada
Not yet recruiting - verified May 2017

Effects of a 4-week Raw, Plant-based Diet on Anthropometric and Cardiovascular Risk Factors

Conditions:   Hypertension;   Elevated Cholesterol;   Overweight and Obesity
Intervention:   Other: Dietary Intervention
Sponsors:   Texas Woman's University;   Montgomery Heart & Wellness
Completed - verified May 2017

Vestibular Stimulation to Trigger Adipose Loss Clinical Trial

Conditions:   Obesity;   Obesity, Abdominal;   Metabolic Syndrome;   Weight Loss
Interventions:   Device: Vestibular nerve stimulator;   Device: Control
Sponsors:   University of California, San Diego;   Neurovalens Ltd
Recruiting - verified May 2017

Vascular Effects of Alirocumab in Acute MI-Patients

Conditions:   Coronary Vessel;   Coronary Circulation;   Atheroma; Myocardial
Interventions:   Drug: Alirocumab 150 MG/ML;   Drug: Placebo
Sponsors:   University Hospital Inselspital, Berne;   Regeneron Pharmaceuticals
Recruiting - verified May 2017

Effects of Two Herbal Dietary Supplements on Lipid Metabolism in Moderate Hypercholesterolemia and Hypertriglyceridemia

Conditions:   Hypercholesterolemia;   Hypertriglyceridemia
Interventions:   Dietary Supplement: VAL070-A;   Dietary Supplement: VAL070-B;   Dietary Supplement: Placebo
Sponsors:   Valbiotis;   BioFortis
Recruiting - verified May 2017

Evaluation of Coronary Artery Plaque Volume Progression/Regression and Safety of Alirocumab in Japanese Patients Hospitalized for Acute Coronary Syndrome With Hypercholesterolemia

Conditions:   Hypercholesterolemia;   Acute Coronary Syndrome
Interventions:   Drug: alirocumab SAR236553;   Drug: atorvastatin;   Drug: rosuvastatin;   Drug: fenofibrate;   Drug: bezafibrate;   Drug: ezetimibe;   Drug: antiplatelets;   Drug: anticoagulants
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified May 2017

The Effect of Olive Leaf Extract Administration on Cardiovascular Health

Conditions:   Overweight and Obesity;   Elevated Cholesterol
Interventions:   Dietary Supplement: OLECOL;   Dietary Supplement: Placebo
Sponsor:   Maastricht University Medical Center
Completed - verified May 2017

A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous (SC) Administered Alirocumab in Healthy Chinese Subjects

Condition:   Hypercholesterolemia
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Drug: placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified May 2017

A Study of ALN-PCSSC in Participants With Homozygous Familial Hypercholesterolemia

Condition:   Homozygous Familial Hypercholesterolemia
Interventions:   Drug: ALN-PCSSC;   Drug: Standard of Care
Sponsor:   The Medicines Company
Recruiting - verified May 2017

Evaluating Effect of the Study Drug Praluent (Alirocumab) on Neurocognitive Function When Compared to Placebo

Condition:   Hypercholesterolemia
Interventions:   Drug: Praluent (Alirocumab);   Drug: Placebo
Sponsors:   Regeneron Pharmaceuticals;   Sanofi
Recruiting - verified May 2017

An 8-Week Dose-Finding Study to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia

Condition:   Hypercholesterolaemia
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Drug: statins;   Drug: ezetimibe;   Drug: cholestyramine;   Drug: fenofibrate;   Drug: omega-3 fatty acids;   Drug: nicotinic acid
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified May 2017

Study to Evaluate the Safety of Repatha® in Pregnancy

Conditions:   Hypercholesterolaemia;   Pregnancy
Intervention:  
Sponsor:   Amgen
Recruiting - verified May 2017

Efficacy of a LRC™ (L. Reuteri NCIMB 30242) Capsule on Managing Cholesterol in Adults

Condition:   Hypercholesterolemia
Interventions:   Dietary Supplement: LRC™ capsule;   Other: Placebo capsule
Sponsor:   UAS Labs LLC
Recruiting - verified May 2017

Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With Hypercholesterolemia

Condition:   Hypercholesterolemia
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Drug: placebo for alirocumab;   Drug: ezetimibe;   Drug: placebo for ezetimibe;   Drug: atorvastatin;   Drug: rosuvastatin;   Drug: simvastatin
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified May 2017

Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects-4

Condition:   Hypercholesterolemia
Interventions:   Biological: Evolocumab;   Drug: Ezetimibe;   Biological: Evolocumab;   Drug: Ezetimibe
Sponsors:   Amgen;   Data Monitoring Committee (DMC)
Recruiting - verified May 2017

Atorvastatin Effectiveness and Safety in Cardiology Patients in Real World Setting

Condition:   Coronary Artery Disease, Hypercholesterolemia, Hypertension
Intervention:   Other: No intervention
Sponsor:   Pfizer
Recruiting - verified May 2017

Effect of Simvastatin Withdrawal on Ocular Endothelial Function

Condition:   Healthy
Interventions:   Device: Dynamic Vessel Analyzer (DVA);   Device: Laser Doppler Velocimetry (LDV);   Drug: Simvastatin;   Other: Placebo
Sponsor:   Medical University of Vienna
Not yet recruiting - verified May 2017

Trial Assessing Efficacy, Safety and Tolerability of PCSK9 Inhibition in Paediatric Subjects With Genetic LDL Disorders

Condition:   Heterozygous Familial Hypercholesterolemia
Interventions:   Drug: Evolocumab;   Drug: Placebo
Sponsor:   Amgen
Recruiting - verified May 2017

Effect of Rice Bran and Cooked Navy Beans on Cholesterol Levels in Healthy Children

Condition:   Hyperlipidemias
Interventions:   Dietary Supplement: Bean powder;   Dietary Supplement: Rice bran;   Dietary Supplement: Control arm;   Dietary Supplement: Bean powder and rice bran
Sponsors:   Poudre Valley Health System;   Colorado State University
Completed - verified May 2017

Treatment for Non-Alcoholic Fatty Liver With Different Doses of Vitamin E

Condition:   Fatty Liver
Interventions:   Drug: Vitamin E 200 IU/d;   Drug: Vitamin E 400 IU/d;   Drug: Vitamin E 800 IU/d;   Behavioral: Diet and Exercise
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified November 7, 2016

Ezetimibe Plus Atorvastatin Versus Atorvastatin in Untreated Subjects With High Cholesterol (P03434)

Conditions:   Hypercholesterolemia;   Atherosclerosis
Interventions:   Drug: Ezetimibe + Atorvastatin;   Drug: Atorvastatin
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified May 2017

Ezetimibe Plus Simvastatin Versus Simvastatin in Untreated Subjects With High Cholesterol (P03435)

Conditions:   Hypercholesterolaemia;   Atherosclerosis
Interventions:   Drug: Ezetimibe + Simvastatin;   Drug: Simvastatin
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified May 2017

Comparison of Ezetimibe Plus Simvastatin Versus Ezetimibe or Simvastatin Alone in Subjects With Primary Hypercholesterolemia (Study P03757)(COMPLETED)

Condition:   Hypercholesterolemia
Interventions:   Drug: Ezetimibe + Simvastatin;   Drug: Simvastatin;   Drug: Ezetimibe
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified May 2017

Effect of Ezetimibe Plus Simvastatin on Flow-Mediated Brachial Artery Vasoactivity in Subjects With Primary Hypercholesterolemia (Study P03336)

Conditions:   Hypercholesterolemia;   Atherosclerosis
Interventions:   Drug: Ezetimibe + Simvastatin;   Drug: Simvastatin;   Drug: Placebo
Sponsor:   Merck Sharp & Dohme Corp.
Terminated - verified May 2017

Ezetimibe Plus Simvastatin Versus Simvastatin Alone in African-American Subjects With Primary Hypercholesterolemia (P03377)

Conditions:   Hypercholesterolemia;   Atherosclerosis
Interventions:   Drug: Ezetimibe + Simvastatin;   Drug: Simvastatin
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified May 2017

Comparison of Co-administration of Ezetimibe Plus Simvastatin Versus Simvastatin Alone in Primary Hypercholesterolemia (P03476)

Conditions:   Atherosclerosis;   Hypercholesterolemia;   Coronary Heart Disease
Interventions:   Drug: Ezetimibe;   Drug: Placebo
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified May 2017

Switching to Rosuvastatin Versus Adding Ezetimibe to Atorvastatin Versus Doubling the Dose of Atorvastatin in Patients With Hypercholesterolemia and Risk Factors (P03708)

Conditions:   Hypercholesterolemia;   Atherosclerosis;   Coronary Artery Disease
Interventions:   Drug: Rosuvastatin;   Drug: Ezetimibe + Atorvastatin;   Drug: Double Atorvastatin
Sponsor:   Merck Sharp & Dohme Corp.
Terminated - verified May 2017

Effect of Ezetimibe Plus Simvastatin Versus Simvastatin Alone on Atherosclerosis in the Carotid Artery (ENHANCE)(P02578)

Conditions:   Atherosclerosis;   Hypercholesterolemia;   Hyperlipoproteinemia Type II
Interventions:   Drug: ezetimibe (plus simvastatin);   Drug: placebo (plus simvastatin)
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified May 2017

Fluvastatin in Adults With Dislipidemia With History of Muscle Problems

Condition:   Dyslipidemia
Intervention:   Drug: Fluvastatin
Sponsor:   Novartis
Completed - verified May 2017