High Cholesterol

Clinical Trial Finder

Many patients with high cholesterol are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg When Added to PCSK9 Inhibitor Therapy

Condition:   Hypercholesterolemia
Interventions:   Drug: bempedoic acid 180mg;   Other: placebo
Sponsor:   Esperion Therapeutics
Recruiting - verified June 2017

Influence of Dietary Nitrate on Skin Inflammation

Conditions:   Cardiovascular Diseases;   Inflammation;   Inflammation; Skin;   Inflammatory Response;   Nitric Oxide
Interventions:   Dietary Supplement: Nitrate-rich Beetroot Juice;   Dietary Supplement: Nitrate-deplete Beetroot Juice
Sponsor:   Queen Mary University of London
Recruiting - verified May 2017

An 8-Week Dose-Finding Study to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia

Condition:   Hypercholesterolaemia
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Drug: statins;   Drug: ezetimibe;   Drug: cholestyramine;   Drug: fenofibrate;   Drug: omega-3 fatty acids;   Drug: nicotinic acid
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified June 2017

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk Open-label Extension

Condition:   Dyslipidemia
Intervention:   Biological: Evolocumab
Sponsor:   Amgen
Active, not recruiting - verified June 2017

Chart Review of Repatha® in Subjects With Hyperlipidaemia

Condition:   Hypercholesterolaemia
Intervention:  
Sponsor:   Amgen
Recruiting - verified June 2017

Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With Hypercholesterolemia

Condition:   Hypercholesterolemia
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Drug: placebo for alirocumab;   Drug: ezetimibe;   Drug: placebo for ezetimibe;   Drug: atorvastatin;   Drug: rosuvastatin;   Drug: simvastatin
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified June 2017

A Study to Assess the Safety and Efficacy of CAT-2054 in Combination With Atorvastatin in Patients With Hypercholesterolemia

Condition:   Hypercholesterolemia
Interventions:   Drug: CAT-2054;   Drug: Placebo;   Drug: Atorvastatin
Sponsor:   Catabasis Pharmaceuticals
Completed - verified June 2017

Trial Assessing Efficacy, Safety and Tolerability of PCSK9 Inhibition in Paediatric Subjects With Genetic LDL Disorders

Condition:   Heterozygous Familial Hypercholesterolemia
Interventions:   Drug: Evolocumab;   Drug: Placebo
Sponsor:   Amgen
Recruiting - verified June 2017

Extension (OLE) Study to Assess Safety and Efficacy of Evolocumab

Condition:   Hypercholesterolemia
Intervention:   Biological: Evolocumab
Sponsor:   Amgen
Active, not recruiting - verified June 2017

Evaluating PCSK9 Binding antiBody Influence oN coGnitive HeAlth in High cardiovascUlar Risk Subjects

Condition:   Dyslipidemia
Interventions:   Biological: Evolocumab (AMG 145);   Other: Placebo;   Drug: Effective statin therapy
Sponsor:   Amgen
Completed - verified June 2017

Vascular Inflammation in Psoriasis-Ustekinumab (VIP-U)

Conditions:   Psoriasis;   Cardiovascular Disease
Interventions:   Drug: Ustekinumab;   Drug: Placebo
Sponsors:   University of Pennsylvania;   Janssen Scientific Affairs, LLC
Active, not recruiting - verified June 2017

Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism

Conditions:   Subclinical Hypercortisolism;   Cushing Syndrome;   Adrenal Neoplasm
Interventions:   Procedure: Adrenalectomy;   Other: Observation
Sponsors:   National Cancer Institute (NCI);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   CC-OADRIS
Active, not recruiting - verified June 7, 2017

Open Label Study of Long Term Evaluation Against LDL-C Trial-2

Condition:   Hyperlipidemia and Mixed Dyslipidemia
Interventions:   Biological: evolocumab (AMG 145) and standard of care;   Other: Standard of care
Sponsor:   Amgen
Active, not recruiting - verified June 2017

GLobal Assessment of Plaque reGression With a PCSK9 antibOdy as Measured by intraVascular Ultrasound

Condition:   Hypercholesterolemia
Interventions:   Biological: Evolocumab;   Drug: Placebo
Sponsor:   Amgen
Completed - verified June 2017

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk

Condition:   Dyslipidemia
Interventions:   Biological: Evolocumab (AMG 145);   Other: Placebo;   Drug: Effective statin therapy
Sponsor:   Amgen
Completed - verified June 2017

Rosuvastatin Calcium Bioequivalence Study - Fast

Condition:   Hypercholesterolaemia
Interventions:   Drug: Crestor®;   Drug: rosuvastatin calcium tablets
Sponsor:   GlaxoSmithKline
Completed - verified June 2017

Trial Assessing Long Term USe of PCSK9 Inhibition in Subjects With Genetic LDL Disorders

Condition:   Severe Familial Hypercholesterolemia
Interventions:   Biological: Evolocumab (AMG145);   Biological: Evolocumab (AMG145)
Sponsor:   Amgen
Active, not recruiting - verified June 2017

Acotral® Versus Zetia® Ezetimibe Bioequivalance Study.

Condition:   Hypercholesterolaemia
Interventions:   Drug: 10mg Ezetimibe;   Drug: 10 mg Ezetimibe - wash out period
Sponsor:   GlaxoSmithKline
Completed - verified June 2017

Open Label Study of Long Term Evaluation Against LDL-C Trial

Condition:   Hypercholesterolemia
Interventions:   Biological: Evolocumab (AMG 145) and standard of care;   Other: Standard of care
Sponsor:   Amgen
Active, not recruiting - verified June 2017

Vitamin D and the Health of Blood Vessels in Kidney Disease

Condition:   Chronic Kidney Disease (CKD)
Interventions:   Dietary Supplement: Dietary supplement;   Dietary Supplement: Vitamin D;   Dietary Supplement: Vitamin D
Sponsors:   University of British Columbia;   The Kidney Foundation of Canada;   Pfizer
Completed - verified June 2017

Effect of Crestor on Lipoprotein Metabolism in Humans

Condition:   Hypercholesterolemia
Intervention:   Drug: Rosuvastatin at 5 mg/day and 40 mg/day
Sponsors:   Atlanta Research and Education Foundation;   AstraZeneca
Completed - verified September 2006

Oral Contraceptives in the Metabolic Syndrome

Conditions:   Metabolic Syndrome X;   Insulin Resistance;   Obesity;   Cardiovascular Diseases
Intervention:   Drug: Ortho Tri Cyclen
Sponsor:   Virginia Commonwealth University
Active, not recruiting - verified June 2017