High Cholesterol

Clinical Trial Finder

Many patients with high cholesterol are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk

Conditions:   Hypercholesterolemia;   Atherosclerotic Cardiovascular Diseases
Interventions:   Drug: ETC-1002;   Drug: Placebo
Sponsor:   Esperion Therapeutics
Recruiting - verified January 2016

Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects-4

Condition:   Hypercholesterolemia
Interventions:   Biological: Evolocumab;   Drug: Ezetimibe;   Biological: Evolocumab;   Drug: Ezetimibe
Sponsors:   Amgen;   Data Monitoring Committee (DMC)
Not yet recruiting - verified February 2016

Single Dose Study of PF-06815345 in Healthy Subjects

Condition:   Hypercholesterolemia
Interventions:   Drug: PF-06815345;   Other: Placebo;   Drug: PF-06815345
Sponsor:   Pfizer
Recruiting - verified February 2016

Efficacy and Safety of Alirocumab in Patients With Hypercholesterolemia Not Adequately Controlled With Non-statin Lipid Modifying Therapy or the Lowest Strength of Statin

Condition:   Hypercholesterolaemia
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Drug: placebo;   Drug: atorvastatin;   Drug: fenofibrate;   Drug: bezafibrate;   Drug: ezetimibe
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified February 2016

Trial Assessing Evolocumab(AMG145) Compared to LDL-C Apheresis in Subjects Receiving LDL-C Apheresis Prior to Study Enrollment

Condition:   Hypercholesterolemia
Interventions:   Biological: evolocumab (AMG 145);   Other: Low Density Lipoprotein Cholesterol (LDL-C) Apheresis
Sponsor:   Amgen
Recruiting - verified February 2016

Study Assessing Safety, Immunogenicity and LDLc -Lowering Activity of 2 PCSK9 Targeting AFFITOPE Vaccines in Healthy Subjects

Condition:   Hypercholesterolemia
Interventions:   Biological: AFFITOPE® AT04A+adjuvant;   Biological: AFFITOPE® AT06A+adjuvant;   Biological: Adjuvant without active component
Sponsors:   Affiris AG;   Medical University of Vienna
Active, not recruiting - verified February 2016

Efficacy, Safety, Tolerability And Actual Use Study Of Bococizumab And An Autoinjector (Pre-Filled Pen) In Subjects With Hyperlipidemia Or Dyslipidemia

Condition:   Hyperlipidemia
Interventions:   Biological: Bococizumab 150mg;   Biological: Bococizumab 75mg;   Biological: Bococizumab 150mg placebo;   Biological: Bococizumab 75mg placebo
Sponsor:   Pfizer
Active, not recruiting - verified February 2016

Physical Exercise Prescription With PEdometeR in General Practice for Patients With Cardiovascular Risk Factors - The PEPPER Pragmatic Trial

Conditions:   Sedentary Lifestyle;   Cardiovascular Diseases;   Hypertension;   Hypercholesterolemia;   Diabetes Mellitus, Type 2
Interventions:   Behavioral: Intervention PPIL;   Behavioral: Control OR
Sponsor:   University Hospital, Angers
Recruiting - verified February 2016

Extension (OLE) Study to Assess Safety and Efficacy of Evolocumab

Condition:   Hypercholesterolemia
Intervention:   Biological: Evolocumab
Sponsor:   Amgen
Enrolling by invitation - verified February 2016

Use of Decision Aids in Clinical Encounters

Condition:   Diabetes, Depression, Cardiovascular Disease,Hypercholesterolemia, Osteoporosis
Interventions:   Other: Active Implementation of ShareEBM Toolkit;   Other: Passive Dissemination of Share EBM
Sponsor:   Mayo Clinic
Enrolling by invitation - verified February 2016

Replacement of Saturated Fat in Dairy on Total Cholesterol

Condition:   Hypercholesterolemia
Interventions:   Dietary Supplement: MUFA-rich dairy products (UHT milk, cheese and butter);   Dietary Supplement: Conventional dairy products (UHT milk, cheese, butter)
Sponsors:   University of Reading;   Medical Research Council
Active, not recruiting - verified February 2016

Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer

Conditions:   Breast Cancer;   Breast Tumors;   Cancer of Breast
Interventions:   Drug: Metformin;   Drug: Atorvastatin;   Procedure: Breast surgery
Sponsor:   Columbia University
Recruiting - verified February 2016

A 52 Week Study To Assess The Use Of Bococizumab (PF-04950615; RN316) In Subjects With Heterozygous Familial Hypercholesterolemia

Condition:   Heterozygous Familial Hypercholesterolemia
Interventions:   Drug: Bococizumab (PF-04950615;RN316);   Other: Placebo
Sponsor:   Pfizer
Active, not recruiting - verified February 2016

Randomized Clinical Trial Of Bococizumab (PF-04950615; RN316) In Subjects With Hyperlipidemia Or Mixed Dyslipidemia At Risk Of Cardiovascular Events

Condition:   Hyperlipidemia
Interventions:   Drug: Bococizumab (PF-04950615;RN316);   Other: Placebo
Sponsor:   Pfizer
Active, not recruiting - verified February 2016

Effect of Plant Sterol Enriched Milk on Plasma Lipid Levels of Humans Breast-fed During Infancy

Conditions:   Hypercholesterolemia;   CVD
Interventions:   Other: Plant Sterols;   Other: High cholesterol;   Other: Placebo
Sponsor:   University of Manitoba
Active, not recruiting - verified March 2013

Effect of HAART Vs. Statin Treatment on Endothelial Function and Inflammation/Coagulation

Condition:   HIV-1 Infection
Interventions:   Drug: Pravastatin sodium;   Drug: Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate;   Drug: Pravastatin sodium
Sponsors:   AIDS Clinical Trials Group;   National Institute of Allergy and Infectious Diseases (NIAID)
Withdrawn - verified January 2016

Open Label Study of Long Term Evaluation Against LDL-C Trial

Condition:   Hypercholesterolemia
Interventions:   Biological: Evolocumab (AMG 145) and standard of care;   Other: Standard of care
Sponsor:   Amgen
Active, not recruiting - verified January 2016

Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care

Conditions:   Infection;   Hypertension;   Pain;   Reflux;   Edema;   Hyperlipidemia;   Hypotension;   Hypercholesterolemia;   Sedation;   Anxiolysis;   Benzodiazepine Withdrawal;   Bipolar Disorder;   Autistic Disorder;   Schizophrenia;   Influenza Treatment or Prophylaxis;   Acute Decompensated Heart Failure;   Stable Angina;   Life-threatening Fungal Infections;   Nosocomial Pneumonia;   Community Acquired Pneumonia;   Acute Bacterial Exacerbation of Chronic Bronchitis;   Complicated Skin and Skin Structure Infections;   Uncomplicated Skin and Skin Structure Infections;   Chronic Bacterial Prostatitis;   Complicated Urinary Tract Infections;   Acute Pyelonephritis;   Uncomplicated Urinary Tract Infections;   Inhalational Anthrax (Post-Exposure);   Infantile Hemangioma;   Withdrawal;   Inflammation;   Bacterial Septicemia;   Cytomegalovirus Retinitis;   Herpes Simplex Virus;   Adenovirus;   Brain Swelling;   Airway Swelling;   Adrenal Insufficiency;   Anxiety;   Nausea;   Vomiting;   Convulsions;   Muscle Spasms;   Seizures;   Epilepsy;   Bartonellosis;   Brucellosis;   Cholera;   Plague;   Psittacosis;   Q Fever;   Relapsing Fever;   Rocky Mountain Spotted Fever;   Trachoma;   Tularemia;   Typhus Fever;   Bronchospasm;   Cardiac Arrest;   Hypersensitivity Reaction;   Cyanide Poisoning;   Acute Bacterial Sinusitis;   Bacterial Meningitis;   Sepsis;   Gastroparesis;   Opioid Addiction;   Migraines;   Headaches
Intervention:   Drug: The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
Sponsors:   Daniel Benjamin;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   The EMMES Corporation;   OpAns, LLC
Recruiting - verified February 2016

The Rogosin Institute Homozygous Familial Hypercholesterolemia Repository

Condition:   Homozygous Familial Hypercholesterolemia
Intervention:  
Sponsor:   The Rogosin Institute
Recruiting - verified February 2016

Serum Lipid Levels and Other Biomarkers of Cardiovascular Disease in Patients With Psoriasis

Conditions:   Psoriasis;   Cardiovascular Diseases;   Dyslipidemia
Intervention:  
Sponsor:   George Washington University
Recruiting - verified February 2016

A Case Control Study Evaluating the Prevalence of Non-Alcoholic Fatty Liver Disease Among Patients With Psoriasis

Conditions:   Psoriasis;   Nonalcoholic Fatty Liver Disease
Intervention:  
Sponsor:   George Washington University
Recruiting - verified February 2016

Abdominal Obesity and Cardiovascular Risk Factors in Women Who Survived Cancer or a Related Illness Following Total Body Irradiation and Stem Cell Transplant

Conditions:   Leukemia;   Hodgkin's Lymphoma;   Non-Hodgkin's Lymphoma;   Myelodysplastic Syndrome
Intervention:   Other: Questionnaires, Laboratory tests, Abdominal MRI
Sponsors:   Memorial Sloan Kettering Cancer Center;   Queen's University, Kingston, Ontario;   Weill Medical College of Cornell University
Active, not recruiting - verified February 2016

Postprandial Lipemia and Endothelial Function in ACCORD- Ancillary to ACCORD

Conditions:   Atherosclerosis;   Cardiovascular Diseases;   Hypercholesterolemia;   Heart Diseases
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

Genetics of Low Density Lipoprotein Subclasses in Hypercholesterolemia

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Hypercholesterolemia
Intervention:  
Sponsors:   University of Washington;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified August 2004

Dietary Treatment of Hyperlipidemia in Women vs. Men

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Hypercholesterolemia
Intervention:  
Sponsors:   University of Washington;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2000

Population-Based Modeling of Cholesterol Lowering in the United States

Conditions:   Cardiovascular Diseases;   Coronary Heart Disease Risk Reduction;   Heart Diseases;   Coronary Disease;   Hypercholesterolemia
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified September 2002

Evaluation of Childhood Blood Pressure and Lipid Screening

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Hypercholesterolemia;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified May 2000

Hyperapo B and Coronary Heart Disease

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Heart Diseases;   Diabetes Mellitus;   Obesity;   Hypercholesterolemia, Familial
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified May 2000

Cholesterol Reduction in Seniors Program (CRISP)

Conditions:   Atherosclerosis;   Cardiovascular Diseases;   Coronary Disease;   Heart Diseases;   Hypercholesterolemia;   Myocardial Ischemia
Intervention:   Drug: lovastatin
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified June 1992