High Cholesterol

Clinical Trial Finder

Many patients with high cholesterol are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Safety and Efficacy of Evolocumab in Addition to Optimal Stable Background Statin Therapy in Chinese Subjects With Primary Hypercholesterolemia and Mixed Dyslipidemia

Conditions:   Primary Hypercholesterolemia;   Mixed Dyslipidemia
Interventions:   Drug: Evolocumab 140 mg SC Q2W;   Drug: Evolocumab 420 mg SC QM;   Other: Placebo SC Q2W;   Other: Placebo SC QM
Sponsor:   Amgen
Active, not recruiting

A Study of Inclisiran in Participants With Homozygous Familial Hypercholesterolemia (HoFH)

Condition:   Homozygous Familial Hypercholesterolemia
Interventions:   Drug: Inclisiran for injection;   Drug: Placebos
Sponsor:   The Medicines Company
Active, not recruiting

A Study of ALN-PCSSC in Participants With Homozygous Familial Hypercholesterolemia (HoFH)

Condition:   Homozygous Familial Hypercholesterolemia
Interventions:   Drug: ALN-PCSSC;   Drug: Standard of Care
Sponsor:   The Medicines Company
Completed

An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia

Condition:   Hypercholesterolaemia
Interventions:   Drug: Alirocumab SAR236553 (REGN727);   Drug: Rosuvastatin;   Drug: Atorvastatin;   Drug: Simvastatin;   Drug: Pravastatin;   Drug: Lovastatin;   Drug: Fluvastatin;   Drug: Ezetimibe;   Drug: Cholestyramine;   Drug: Nicotinic acid;   Drug: Fenofibrate;   Drug: Omega-3 fatty acids;   Drug: Placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting

Oil Consumption and Cholesterol

Condition:   Hypercholesterolemia
Interventions:   Dietary Supplement: Cottonseed Oil;   Dietary Supplement: Olive Oil
Sponsors:   University of Georgia;   National Cottonseed Products Association;   Cotton Incorporated
Recruiting

Evolocumab Plus Ezetimibe in High Risk Haemodialized Statin Intolerant Patients

Conditions:   Hypercholesterolemia;   Chronic Kidney Disease Requiring Chronic Dialysis
Interventions:   Drug: Evolocumab;   Drug: Placebo;   Drug: Ezetimibe
Sponsors:   Policlinico Casilino ASL RMB;   IRCCS San Raffaele
Recruiting

Long Term Safety Study of PRALUENT

Conditions:   Heterozygous Familial Hypercholesterolemia;   Non-familial Hypercholesterolemia
Intervention:   Drug: Praluent
Sponsors:   Regeneron Pharmaceuticals;   Sanofi
Terminated

Chart Review of Repatha® in Subjects With Hyperlipidaemia

Condition:   Hypercholesterolaemia
Intervention:  
Sponsor:   Amgen
Recruiting

The Genetic, Protein, and Lipid Basis of Variation in Cholesterol Efflux

Condition:   Lipid Metabolism Disorders
Intervention:  
Sponsors:   University of Texas Southwestern Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Suspended

To Evaluate Safety and Effectiveness of RovatitanTab.

Conditions:   Hypertension;   Hyperlipidemias
Intervention:   Drug: Rosuvastatin/Valsartan
Sponsor:   LG Chem
Not yet recruiting

Efficacy and Safety of Pitavastatin in a Real-world Setting

Condition:   Hypercholesterolemia
Intervention:   Drug: Pitavastatin
Sponsor:   JW Pharmaceutical
Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD8233 in Healthy Male Subjects With Increased Elevated LDL-C Levels.

Condition:   Hypercholesterolemia
Intervention:   Drug: AZD8233
Sponsors:   AstraZeneca;   Parexel
Active, not recruiting

Causes and Natural History of Dyslipidemias

Conditions:   Hypercholesterolemia;   Atherosclerosis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Pentoxifylline, Atorvastatin, and Vitamin E in Treating Patients With Erectile Dysfunction After Radiation Therapy for Prostate Cancer

Conditions:   Male Erectile Disorder;   Prostate Adenocarcinoma;   Erectile Dysfunction, CTCAE;   Impotence
Interventions:   Drug: Atorvastatin;   Drug: Pentoxifylline;   Dietary Supplement: Vitamin E Compound
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Recruiting

Aging, Aged Garlic, Vascular Function and Muscle Oxygenation

Conditions:   Aging;   Hypertension;   Dyslipidemias;   Abdominal Obesity
Interventions:   Dietary Supplement: Aged Garlic Extract;   Other: Placebo
Sponsor:   Universidade Federal do Rio de Janeiro
Completed

Pediatric Reporting of Adult-Onset Genomic Results

Conditions:   Hereditary Breast and Ovarian Cancer Syndrome;   Lynch Syndrome;   Familial Hypercholesterolemia
Interventions:   Genetic: Receive an adult-onset result;   Genetic: Receive a pediatric-onset result;   Genetic: Control - No Result
Sponsors:   Geisinger Clinic;   National Human Genome Research Institute (NHGRI)
Recruiting

Genetics of Obesity, Diabetes, and Heart Disease in African Diaspora Populations

Conditions:   Diabetes;   Cardiovascular Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Enrolling by invitation

Open-Label Study To Evaluate MN-001 on HDL & Triglyceride in NASH & NAFLD Subjects

Conditions:   Non-alcoholic Steatohepatitis;   Hypertriglyceridemia;   Non-alcoholic Fatty Liver Disease;   Hypercholesterolemia
Intervention:   Drug: MN-001
Sponsor:   MediciNova
Completed

Optimizing Statin Tratment in People Living With Diabetes

Condition:   Diabetes
Intervention:  
Sponsor:   University Hospital, Montpellier
Completed

Health and Cardiovascular Risk Factors in Slums.

Conditions:   Cardiovascular Risk Factor;   Cardiovascular Diseases
Intervention:   Other: None intervention is planned.
Sponsors:   Fundacion GESICA;   Escuela de Psicología Social Pichon Riviere;   Corriente Salvador Maza
Recruiting

Electronic Medical Records and Genomics (eMERGE) Phase III

Conditions:   Cardiac Disease;   Cancer;   Hypercholesterolemia;   Diabetes;   Kidney Diseases;   Neuromuscular Diseases
Intervention:  
Sponsor:   Vanderbilt University Medical Center
Completed

Analysis of Metabolic State in Normal-weight and Overweight-obese After Lifestyle Improvement and/or Weight Loss

Condition:   Overweight and Obesity
Intervention:   Other: Dietary and physical activity intervention
Sponsor:   University of the Balearic Islands
Recruiting

Hypertriglyceridaemia - Cause and Effects

Condition:   Hypertriglyceridaemia
Intervention:  
Sponsor:   Manchester University NHS Foundation Trust
Recruiting

Efficacy and Safety of Angelica Gigas Nakai and Allium Cepa L.Extract Mixtures on the Improvement of Blood Flow

Condition:   Blood Flow
Interventions:   Dietary Supplement: Angelica Gigas Nakai and Allium Cepa L.Extract Mixtures;   Dietary Supplement: Placebo
Sponsor:   Chonbuk National University Hospital
Recruiting