Heart Failure

Clinical Trial Finder

Many patients with heart failure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Short and Long Term Prognosis of Patients Admitted to the ED With Acute Heart Failure

Condition:   Acute Heart Failure
Sponsor:   University of Monastir

Sleep Disordered Breathing in Acute Congestive Heart Failure

Conditions:   Obstructive Sleep Apnea;   Decompensated Congestive Heart Failure
Sponsor:   University of California, San Diego
Not yet recruiting

Risk and Benefit Informed MTM Pharmacist Intervention in Heart Failure

Condition:   Heart Failure
Intervention:   Other: Referral to MTM Pharmacist
Sponsor:   Geisinger Clinic
Not yet recruiting

Mapping and Pacing of the His Bundle for Heart Failure Patients With Left Bundle Branch Block

Conditions:   Heart Failure;   Left Bundle-Branch Block
Interventions:   Procedure: Mapping and Pacing the His Bundle;   Procedure: Placing a guidewire in Coronary sinus for measurement of Q-LV during His Bundle pacing or, if needed, for LV pacing
Sponsor:   St. Jude Medical
Not yet recruiting

Effects of Iron Therapy and Exercise Training in Patients With Heart Failure and Iron Deficiency

Conditions:   Heart Failure With Reduced Ejection Fraction;   Exercise Training;   Ferric Carboxymaltose
Interventions:   Behavioral: Initial exercise training;   Drug: Initial FCM;   Drug: Subsequent FCM;   Behavioral: Subsequent exercise training
Sponsor:   Herzzentrum Bremen
Not yet recruiting

A Clinical Follow-up Study of Heart Failure Patients.

Condition:   Heart Failure
Sponsor:   Shanghai Zhongshan Hospital

Interleukin-1 Blockade In Recently Decompensated Heart Failure - 2

Conditions:   Heart Failure, Systolic;   Inflammation
Interventions:   Drug: Anakinra;   Drug: Placebo
Sponsor:   Virginia Commonwealth University

A Study to Assess the Reaction of Body for Four Different Formulations of AZD9977 (Part A) and Influence of Food and Lower Dose of a Selected Formulation (Part B) in Healthy Male Subjects

Condition:   Heart Failure
Interventions:   Drug: Treatment A;   Drug: Treatment B;   Drug: Treatment C;   Drug: Treatment D
Sponsor:   AstraZeneca
Not yet recruiting

A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD9977 in Japanese Healthy Participants With Single and Multiple Ascending Dose Administration

Condition:   Heart Failure
Interventions:   Drug: AZD9977;   Drug: Placebo
Sponsors:   AstraZeneca;   Parexel
Not yet recruiting

Cardiac Strains for Optimization of CRT in Non-Responders

Condition:   Chronic Heart Failure
Interventions:   Device: CRT-D re-programming;   Diagnostic Test: Trans-Thoracic Echocardiography
Sponsor:   University Hospital Ostrava

Effect of Dapagliflozin Plus Low Dose Pioglitazone on Hospitalization Rate in Patients With HF and HFpEF

Condition:   Risk Reduction
Interventions:   Drug: Pioglitazone Plus dapaglifliozin;   Drug: Placebo
Sponsor:   Hamad Medical Corporation
Not yet recruiting

Heart Failure After Heart Transplantation Due to Chronic Rejection

Conditions:   Cardiac Allograft Vasculopathy;   Chronic Rejection of Cardiac Transplant;   Graft Dysfunction
Intervention:   Diagnostic Test: Diagnostic investigations
Sponsor:   Sahlgrenska University Hospital, Sweden

Blood Pressure Control Target in Diabetes

Condition:   Blood Pressure Control Target in Diabetes
Intervention:   Other: Treatment strategy regarding different systolic BP goals
Sponsor:   Shanghai Jiao Tong University School of Medicine
Not yet recruiting

Electrical Muscle Stimulation in Congestive Heart Failure

Conditions:   Congestive Heart Failure;   Electric Muscle Stimulation;   Severe Decondition;   Elderly Person;   Exercise Capacity;   Activities of Daily Living
Intervention:   Device: Electrical muscle devise
Sponsor:   Kantonsspital Olten

Zero Sodium Peritoneal Dialysate Protocol Pilot Study

Conditions:   Potential Applications for Heart Failure;   Volume Overload
Interventions:   Drug: Two-hour dwell with 10% dextrose in sterile water;   Drug: Two-hour dwell with Dianeal Low-Calcium with 4.25% Dextrose
Sponsor:   Yale University

Stem Cell Therapy in Non-IschEmic Non-treatable Dilated CardiomyopathiEs II: a Pilot Study

Condition:   Non-ischemic Dilated Cardiomyopathy
Interventions:   Biological: Allogeneic adipose-derived stromal cells (CSCC_ASC);   Other: Control group
Sponsors:   JKastrup;   University Medical Centre Ljubljana
Not yet recruiting

ARrhythmias in MYocarditis

Conditions:   Myocarditis;   Heart Failure;   Endomyocardial Biopsy;   Arrythmia;   Sudden Cardiac Death;   Biomarker;   Cardiomyopathy
Intervention:   Diagnostic Test: ECG holter monitoring
Sponsor:   Medical University of Warsaw

Safety and Efficacy of the Gastric Reactance (XL) in Patients Post-operated of Elective Cardiac Surgery

Conditions:   Cardiac Failure;   Ventricular Dysfunction;   Valvular Heart Disease
Intervention:   Device: Florence device
Sponsors:   Critical Perfusion Inc.;   Instituto Nacional de Cardiologia Ignacio Chavez;   National Council of Science and Technology, Mexico;   Gerbera Capital;   Alandra Medical SAPI de CV

The EXCEL Study: A Comprehensive Bi- National Registry on the Treatment and Outcomes of Patients Requiring ECMO

Conditions:   Critically Ill;   Acute Respiratory Failure;   Acute Heart Failure;   Cardiac Arrest
Sponsor:   Australian and New Zealand Intensive Care Research Centre
Not yet recruiting

Brief CBT for Patients Undergoing TAVR

Condition:   Depression, Anxiety
Intervention:   Behavioral: Brief Bedside CBT
Sponsor:   Stanford University

Quality IQ Patient Simulation Physician Practice Measurement and Engagement

Conditions:   Diabetes;   Hypertension;   Depression;   Osteoarthritis;   Asthma;   Pain;   Heart Failure
Interventions:   Other: Continuing Medical Education;   Other: Quality IQ Patient Simulations
Sponsors:   Qure Healthcare, LLC;   CE Outcomes

Pericardial Matrix With Mesenchymal Stem Cells for the Treatment of Patients With Infarcted Myocardial Tissue

Condition:   Myocardial Infarction
Interventions:   Combination Product: PeriCord: Expanded and cryopreserved allogeneic umbilical cord Wharton´s jelly-derived adult mesenchymal stem cells colonized on human pericardial matrix.;   Procedure: Surgery by sternotomy
Sponsors:   Fundació Institut Germans Trias i Pujol;   Germans Trias i Pujol Hospital
Not yet recruiting

China Tongxinluo Study for Myocardial Protection in Patients With Acute Myocardial Infarction

Condition:   Acute Myocardial Infarction
Interventions:   Drug: Tongxinluo;   Drug: Placebos
Sponsor:   China National Center for Cardiovascular Diseases

Red Cell Distribution Width Versus Presepsin (Soluble CD14) as a Prognostic Marker in Critically-ill Sepsis Patients

Condition:   Sepsis
Interventions:   Diagnostic Test: Red Cell Distribution Width (RDW);   Diagnostic Test: Presepsin (sCD14-ST)
Sponsor:   Ain Shams University

Impact of OSA on Outcomes in Acute Coronary Syndrome

Conditions:   OSA;   ACS - Acute Coronary Syndrome;   Major Adverse Cardiac Events
Intervention:   Diagnostic Test: ApneaLink Type III portable sleep study
Sponsor:   MetroHealth Medical Center

Physiological Reconditioning Program Administered Remotely in Patients Undergoing Transcatheter Aortic Valve Replacement: A Pilot Study

Conditions:   Frailty;   Transcatheter Aortic Valve Replacement;   Rehabilitation
Intervention:   Other: Remotely administered physiological reconditioning program
Sponsor:   St. Michael's Hospital, Toronto
Not yet recruiting

Multicenter Registry Study of Aortic Valve Stenosis in Zhejiang Elderly(Mrs AVS)

Condition:   Valvular Heart Disease
Intervention:   Other: Our study type is observational
Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University

A Study of People With Type 2 Diabetes Who Have Diseases That Affect the Heart and Blood Vessels. The Study Will Also Look at the Treatment of a Group of These People in Hospitals in Portugal

Condition:   Diabetes Mellitus, Type 2
Intervention:   Other: No treatment given
Sponsor:   Novo Nordisk A/S
Not yet recruiting

Threshold Response of Lumbar Selective Nerve Root Block in Predicting Good Outcome Following Lumbar Foraminotomy

Conditions:   Back Pain;   Radiculopathy Lumbar;   Degenerative Lumbar Spinal Stenosis
Intervention:   Diagnostic Test: Selective Nerve Root Block
Sponsors:   The Cleveland Clinic;   Lumbar Spine Research Society

Reduction of Postoperative Gastrointestinal Dysmotility Following Total Laparoscopic Hysterectomy.

Conditions:   Postoperative Passage of Flatus;   Postoperative Bowel Movement
Interventions:   Drug: Colace 100Mg Capsule;   Drug: Miralax
Sponsors:   The Cleveland Clinic;   Michael Sprague MD;   Pamela Frazzini-Padilla MD;   Katherine Smith MD;   Jennifer Afton Cooper MD

Predicting the Development of Myocardial Depression in Acute Neurological Patients

Conditions:   Myocardial Depression;   Takotsubo Syndrome;   Subarachnoid Hemorrhage;   Acute Ischemic Stroke
Sponsor:   Ohio State University

Stimulation Parameters and Non-motor Symptoms in PD Treated With DBS

Condition:   Parkinson Disease
Intervention:   Procedure: Personalized DBS adjustments
Sponsor:   Darlene Floden

Accuracy of the Apple Watch Series 4 for Detection of Heart Rhythm: A Pilot Study

Conditions:   Heart Rate Fast;   Heart Rate Low
Interventions:   Device: Apple Watch 4 Series Device;   Device: Continuous Telemetry Monitor
Sponsors:   The Cleveland Clinic;   Case Western Reserve University

Incidence and Prognostic Implication of Acute CV Events in Patients Hospitalized for CAP in Internal Medicine Units.

Condition:   Cardiovascular Events
Intervention:   Other: No intervention
Sponsor:   Fadoi Foundation, Italy

Comparison of Dorsal Column Stimulation to Dorsal Root Ganglion Stimulation for Complex Regional Pain Syndrome

Condition:   Complex Regional Pain Syndrome
Interventions:   Device: The Nuvectra Algovita Dorsal Column Spinal Cord Stimulator;   Device: The Axium Neurostimulator System
Sponsor:   The Cleveland Clinic
Not yet recruiting

Improved Prediction of Functional Recovery After Revascularisation Using Combined Assessment of Myocardial Ischaemia and Viability by CMR - Pilot Study

Conditions:   Cardiovascular Diseases;   Ischemic Cardiomyopathy;   Cardiac Ischemia
Interventions:   Device: Research CMR scan;   Device: Research 3D transthoracic echocardiogram;   Other: 6-minute walk test
Sponsor:   King's College London

Effect of ARNI in Patients With Persistent AF and Enlarged Left Atrium After Catheter Ablation

Conditions:   Atrial Fibrillation;   Cardiac Remodeling, Atrial;   Sacubitril/Valsartan
Interventions:   Drug: Sacubitril-Valsartan;   Drug: Valsartan
Sponsor:   The Second Affiliated Hospital of Chongqing Medical University
Not yet recruiting

Long-Term Extension Study of PB1046 in PAH Subjects Having Completed Studies PB1046-PT-CL-0004 or PB1046-PT-CL-0005

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: PB1046 Injection
Sponsor:   PhaseBio Pharmaceuticals Inc.
Not yet recruiting

PeRcutaneous cOronary Intervention of Native Coronary arTery Versus Venous Bypass Graft in Patients With Prior CABG

Condition:   Coronary Artery Disease
Intervention:   Procedure: Percutaneous coronary intervention
Sponsor:   VU University Medical Center
Not yet recruiting

The Distal (SnUffbox) Versus Proximal Radial artERy Access for Coronary Angiography and Interventions Registry (SUPER-Prospective)

Condition:   Coronary Angiography
Intervention:   Procedure: Left heart catheterization
Sponsor:   University of Florida
Not yet recruiting

STUDIIO-Diabetes Pilot: STUdy of Drug Insurance to Improve Outcomes of Diabetes

Conditions:   Type 2 Diabetes Mellitus;   Medication Adherence;   Medication Compliance;   Medication Nonadherence
Intervention:   Other: Drug cards
Sponsors:   Sunnybrook Health Sciences Centre;   Canadian Institutes of Health Research (CIHR)
Not yet recruiting

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