Heart Failure

Clinical Trial Finder

Many patients with heart failure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Acute Heart Failure - COngestion Discharge Evaluation

Condition:   Acute Heart Failure
Interventions:   Procedure: Clinical examination centered on congestion;   Procedure: Cardiac, pulmonary, peritoneal, jugular and renal venous Doppler ultrasounds;   Procedure: Blood sample retrieved for biological assessment and biobanking;   Procedure: Telephone follow-up
Sponsor:   Central Hospital, Nancy, France
Not yet recruiting

Korean Heart Failure Registry III

Condition:   Acute Heart Failure
Sponsors:   Seoul National University Bundang Hospital;   Korean Society of Heart Failure

Tolvaptan add-on Therapy to Overcome Loop Diuretic Resistance in Acute Heart Failure With Renal Dysfunction

Condition:   Acute Heart Failure
Intervention:   Drug: Tolvaptan 15 MG
Sponsors:   Gia Dinh People Hospital;   Otsuka Pharmaceutical Vietnam
Not yet recruiting

Study of the Safety of BMS-986259 in Participants With Post-acute Decompensated Heart Failure

Condition:   Acute Decompensated Heart Failure
Interventions:   Drug: BMS-986259;   Other: Placebo
Sponsor:   Bristol-Myers Squibb
Not yet recruiting

Selfcare MAnagement InteRvenTion in Heart Failure II (SMART HF II)

Condition:   Heart Failure
Intervention:   Device: LifePod
Sponsor:   Lund University

Study to Evaluate Sex Differences in the Acute Effects of PL-3994 in Heart Failure Subjects

Condition:   Heart Failure With Preserved Ejection Fraction
Interventions:   Drug: PL-3994 Aqueous Intravenous Solution Dose Ascention;   Drug: PL-3994 Aqueous Intravenous Solution Single Dose
Sponsor:   Palatin Technologies
Not yet recruiting

B-line by Lung US in Patients With Acute Decompensated Heart Failure

Condition:   Heart Failure
Intervention:   Diagnostic Test: Lung ultrasound
Sponsor:   Asan Medical Center

Limitations of Aerobic Capacity in Chronic Heart Failure

Condition:   Chronic Heart Failure
Intervention:   Other: Exercise with and without Codeine
Sponsor:   University of Leeds

Electronic Transmission of Laboratory and Adherence Records of Heart Failure Patients to General Practitioners Screen

Condition:   Heart Failure
Intervention:   Other: Transmission of adherence records
Sponsor:   University Hospital, Basel, Switzerland
Not yet recruiting

Cardiac Resynchronisation Therapy In Patients With Heart Failure: Mechanistic Insights From Cardiac MRI And Electroanatomical Mapping

Condition:   Heart Failure
Interventions:   Procedure: Temporary pacing Study;   Radiation: Thoracic CT;   Diagnostic Test: Acute hemodynamic study;   Diagnostic Test: Non-invasive body surface mapping;   Diagnostic Test: Invasive catheter-based mapping
Sponsors:   Guy's and St Thomas' NHS Foundation Trust;   King's College London

Study of Verinurad in Heart Failure With Preserved Ejection Fraction

Condition:   Heart Failure With Preserved Ejection Fraction (HFpEF)
Interventions:   Drug: Verinurad;   Drug: Allopurinol;   Drug: Placebo for verinurad;   Drug: Placebo for allopurinol
Sponsor:   AstraZeneca
Not yet recruiting

Cardiogenic Shock Integrated PHenotyping for Event Reduction

Condition:   Heart Failure
Intervention:   Diagnostic Test: ELISA
Sponsor:   Niguarda Hospital

CCM Italian Registry

Condition:   Heart Failure
Intervention:   Device: CCM device implantation
Sponsors:   S. Andrea Hospital;   Ospedale Umberto I di Torino;   A.O.U. Città della Salute e della Scienza - Molinette Hospital;   Ospedale Cardinal Massaia;   Azienda Ospedaliero Universitaria Maggiore della Carita;   Azienda Ospedaliera S. Maria della Misericordia;   IRCCS Multimedica;   San Giovanni di Dio Hospital;   Monaldi Hospital;   Ospedale Miulli, Acquaviva delle Fonti;   Ospedale San Bortolo di Vicenza;   The Mediterranean Institute for Transplantation and Advanced Specialized Therapies;   ASST Fatebenefratelli Sacco;   Ospedale Policlinico San Martino;   Azienda Ospedaliera Bolognini di Seriate Bergamo;   Federico II University;   Ospedale Santa Croce-Carle Cuneo;   Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria;   Martini Hospital, Turin, Italy;   Ospedale di Ariano Irpino;   Ospedale di Borgomanero;   ASL Verbano-Cusio-Ossola;   Policlinico Hospital;   Azienda Ospedaliero Universitaria di Cagliari;   Fatebenefratelli Hospital;   Centro Cuore Morgagni, Pedara;   Santa Maria delle Grazie, Pozzuoli;   Ospedale di Gorizia;   ASP Enna;   Ospedale Garibaldi, Catania;   Ospedali Riuniti Anzio-Nettuno;   Ospedale Fracastoro, Soave San Bonifacio;   Ospedale Magalini, Villafranca;   Casa di Cura Pierangeli, Pescara

Radiofrequency (RF) Ablation for Atrial Fibrillation (AF) in Patients With Heart Failure With Preserved Ejection Fraction

Condition:   Heart Failure With Preserved Ejection Fraction
Intervention:   Procedure: RF ablation of AF using CARTO 3 and a Thermocool ST SF ablation catheter
Sponsors:   University of Rochester;   Biosense Webster, Inc.
Not yet recruiting

Multi Point Pacing vs. Conventional STUDY PROTOCOL

Condition:   Compare Two Programming Modalities for CRT Devices in Heart Failure Patients With an Indication for Cardiac Resynchronization Therapy
Interventions:   Device: conventional CRT;   Device: MPP CRT
Sponsor:   CMC Ambroise Paré

The Efficacy and Safety of Zhigancao Tang Granule for HFpEF of Qi-Yin Dificiency

Condition:   Heart Failure With Preserved Ejection Fraction
Interventions:   Drug: Zhigancao Tang granule;   Drug: Zhigancao Tang placebo granule
Sponsor:   Shanghai University of Traditional Chinese Medicine
Not yet recruiting

The Application of the Umbilical Cord Mesenchymal Stem Cells in the Complex Treatment of Chronic Heart Failure of Non-ischemic Etiology

Conditions:   Chronic Heart Failure;   Non-ischemic Cardiomyopathy;   Non-ischemic Dilated Cardiomyopathy
Interventions:   Procedure: Cardiac catheterization;   Biological: Intracoronary administration of the umbilical cord-derived mesenchymal stromal cells
Sponsors:   The Research-Clinical Center for Cardiac Surgery and Transplantology LLP;   State-Financed Health Facility "Samara Regional Medical Center Dinasty"
Enrolling by invitation

Integrated Distance Management Strategy for Patients With Cardiovascular Diseases in the Context of COVID-19

Conditions:   Angina Pectoris;   Acute Coronary Syndrome;   Coronary Syndrome;   Coronary Artery Disease;   Angioplasty;   Stent Restenosis;   Hypertension;   Heart Failure, Systolic;   Depression, Anxiety;   Covid-19;   Isolation, Social
Intervention:   Other: Tele-medicine platform
Sponsors:   Professor Adrian Covic;   Medical Sciences Academy - Romania;   Victor Babes Clinical Hospital of Infectious Diseases - Bucharest

Catheter Ablation for Atrial Fibrillation in Preserved Ejection Fraction

Condition:   Atrial Fibrillation
Intervention:   Other: Catheter Ablation
Sponsors:   University Hospital Heidelberg;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)

The Safety and Efficacy of Istaroxime for Pre-Cardiogenic Shock

Condition:   Cardiogenic Shock
Interventions:   Drug: Istaroxime;   Drug: Placebo
Sponsors:   Windtree Therapeutics;   Momentum Research, Inc.
Not yet recruiting

Effects of Sitagliptin in Individuals With Genetically Decreased DPP4

Conditions:   Genetics Disease;   Type2 Diabetes;   Heart Failure
Interventions:   Drug: Sitagliptin 100mg;   Drug: Placebo Oral Tablet
Sponsor:   University of Pennsylvania

Real Life Study on Iron Isomaltoside 1000 in the Treatment of ID in CKD, Heart Failure, ObGyn, IBD, Cancer and Elective Surgery (Real-CHOICE).

Conditions:   Iron-Deficiency Anemia;   Iron-Deficiency
Intervention:   Drug: Iron isomaltoside 1000
Sponsor:   Pierre Fabre Pharma AG
Not yet recruiting

HIV-HEART Aging Study (15 Year Follow up)

Conditions:   HIV Infections;   Coronary Disease;   Myocardial Infarction;   HIV Encephalopathy;   Aging;   Heart Failure;   Weight Gain
Sponsor:   University Hospital, Essen
Not yet recruiting

Morbidity and Mortality Due to Deferral of Aortic Valve Replacement in Patients With Severe Aortic Stenosis

Condition:   Aortic Valve Stenosis
Intervention:   Device: TAVR or SAVR
Sponsor:   University Hospital Inselspital, Berne

Post-Surgery Extracorporeal Life Support

Conditions:   Cardiogenic Shock;   Extracorporeal Life Support;   Extracorporeal Membrane Oxygenation Complication;   Post Cardiac Arrest Syndrome;   Post-cardiac Surgery
Intervention:   Procedure: ECLS
Sponsors:   University of Florence;   Sandro Gelsomino;   Edvin Prifti;   Francesco Cabrucci;   Marco Bugetti;   Orlando Parise;   Aleksander Dokollari

Remote Physiologic Monitoring to Detect Inflammatory Bowel Disease (IBD) Flares: A Feasibility Study

Condition:   Inflammatory Bowel Diseases
Intervention:   Device: Whoop strap 3.0
Sponsor:   Milton S. Hershey Medical Center
Not yet recruiting

Cell Therapy Using Umbilical Cord-derived Mesenchymal Stromal Cells in SARS-CoV-2-related ARDS

Conditions:   Severe Acute Respiratory Syndrome Coronavirus 2;   Severe Acute Respiratory Distress Syndrome
Interventions:   Biological: Umbilical cord Wharton's jelly-derived human;   Other: NaCl 0.9%
Sponsor:   Assistance Publique - Hôpitaux de Paris
Not yet recruiting

Evaluation of Laser Acupuncture on Health Promotion of Sub-health People

Condition:   Suboptimal Health Status
Intervention:   Device: Low level laser therapy
Sponsor:   Taipei Veterans General Hospital, Taiwan

Influence Of Incomplete Revascularization on Long-Term Outcomes After Primary Percutaneous Coronary Intervention (PPCI)

Condition:   Primary Percutaneous Coronary Intervention
Sponsor:   Amany Edward Ramzy

Levosimendan for Veno-arterial ECMO Weaning

Conditions:   Cardiogenic Shock;   Refractory Shock
Interventions:   Other: Data collection;   Other: Data analysis
Sponsor:   Hospices Civils de Lyon

Addressing Sleep Apnea Post-Stroke/TIA

Conditions:   Ischemic Stroke;   Transient Ischemic Attack (TIA);   Obstructive Sleep Apnea
Intervention:   Other: ASAP Intervention Quality Improvement Protocol
Sponsor:   VA Office of Research and Development
Not yet recruiting

Meta-analysis of Fish Oil Supplementation and Cardiovascular Outcomes in Diabetes

Conditions:   Type2 Diabetes;   Heart Failure;   Myocardial Infarction;   Stroke;   Arrhythmia;   Cardiovascular Diseases
Intervention:   Dietary Supplement: fish oil supplement
Sponsors:   University of Toronto;   Diabetes and Nutrition Study Group (DNSG) of the European Association for the Study of Diabetes (EASD);   Canadian Institutes of Health Research (CIHR);   Diabetes Canada
Active, not recruiting

Safety in Convalescent Plasma Transfusion to COVID-19

Condition:   COVID-19
Intervention:   Biological: Convalescent Plasma
Sponsors:   Hospital San Jose Tec de Monterrey;   Tecnologico de Monterrey
Not yet recruiting

Prognostic Factors Keeping Track for Covid19 Pneumonia

Conditions:   Pneumonia, Viral;   Hypertension;   Diabetes Mellitus;   Obesity;   Cardiovascular Diseases;   Obstructive Lung Disease
Sponsor:   Catholic University of the Sacred Heart

"Post-acute Pickwick Study" (Postacute-Pick-2020)

Conditions:   Acute on Chronic Hypercapnic Respiratory Failure;   Obesity Hypoventilation Syndrome (OHS)
Interventions:   Procedure: "Lifestyle modifications" group (Control);   Procedure: Automatic NIV;   Procedure: CPAP treatment group;   Procedure: NIV treatment groups
Sponsor:   Juan F. Masa
Not yet recruiting

Dolutegravir and Clinical Outcomes Among ART-recipients in Brazil

Conditions:   HIV Infections;   Clinical Outcomes;   Adverse Drug Event;   Effect of Drugs
Intervention:   Other: No intervention
Sponsors:   Fundação Bahiana de Infectologia;   University of New Mexico;   Instituto Infectologia Evandro Chagas, Rio de Janeiro;   Instituto de Infectologia Emilio Ribas, S. Paulo;   Instituto de Medicina Tropical de Manaus;   Hospital da Clinicas de Porto Alegre;   Centro de Referência e Tratamento, CRT, São Paulo, SP;   Universidade Federal de Minas gerais, MG);   EMESCAN, Vitória, Espírito Santo;   Hospital Partenon, Porto Alegre;   Hospital das Clinicas, Recife
Not yet recruiting

ACE Inhibitors or ARBs Discontinuation in Context of SARS-CoV-2 Pandemia

Condition:   History of Cardiovascular Disease Treated With RAS Blockers and With SARS-CoV-2 Infection
Interventions:   Drug: 1: discontinuation of RAS blocker therapy;   Drug: 2: continuation of RAS blocker therapy
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Groupe Hospitalier Pitié-Salpêtrière
Not yet recruiting

Damage and Renal Clearance of Glycocalyx in Cardiac Surgery

Conditions:   Glycocalyx;   Cardio-Renal Syndrome
Sponsors:   Miguel Ayala León;   Instituto Nacional de Cardiologia Ignacio Chavez

cliNIcal sCEnarios and Pathophysiology of Atrial Fibrillation

Condition:   Atrial Fibrillation
Sponsor:   Policlinico Casilino ASL RMB
Not yet recruiting

Effect Levosimendan Administration on Postoperative NT-proBNP in Cardiac Risk Patients

Condition:   Cardiovascular Risk Factor
Interventions:   Drug: Levosimendan;   Drug: Placebo
Sponsor:   Medical University of Vienna
Not yet recruiting

Postmastecomy Internal Mammary Nodal Irradiation for High-risk Breast Cancer Patients

Condition:   Breast Cancer
Interventions:   Radiation: internal mammary nodal irradiation;   Radiation: no internal mammary nodal irradiation
Sponsors:   Chinese Academy of Medical Sciences;   Hebei Medical University Fourth Hospital;   Shanghai Zhongshan Hospital;   Zhejiang Cancer Hospital;   Beijing Hospital;   Liaoning Tumor Hospital & Institute;   Jilin Provincial Tumor Hospital;   Shanxi Province Cancer Hospital;   Tangshan People's Hospital;   China-Japan Union Hospital, Jilin University;   First Hospital of Jilin University;   West China Hospital;   Peking Union Medical College Hospital;   Anyang Tumor Hospital;   Guizhou people's Hospital;   Henan Cancer Hospital;   Wuhan University;   Beijing Cancer Hospital;   Fudan University;   TAIZHOU HOSPITAL OF ZHEJIANG PROVINCE;   Fourth Military Medical University;   Shanxi Dayi Hospital;   First Affiliated Hospital Xi'an Jiaotong University;   Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University;   Fuwai Hospital of Chinese Academy of Medical Sciences

Randomized Controlled Trial Between Auto-titration and Manual Titration of Non-invasive Ventilation in Obesity Hypoventilation Syndrome

Conditions:   Chronic Hypercapnic Respiratory Failure;   Obesity Hypoventilation Syndrome
Interventions:   Device: Manual Non invasive ventilation titration;   Device: Automatic Non invasive ventilation titration
Sponsor:   Sociedad Española de Neumología y Cirugía Torácica