Heart Failure

Clinical Trial Finder

Many patients with heart failure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Heart Failure Precision Medicine Study

Condition:   Heart Failure
Intervention:   Device: Telemonitoring devices
Sponsor:   University of California, Davis
Recruiting

Changes in the T-wave Alternans in Patients With Heart Failure Treated Wih Sacubitril-Valsartan

Condition:   Heart Failure
Intervention:   Drug: Sacubitril-Valsartan
Sponsors:   Fundación Pública Andaluza para la gestión de la Investigación en Sevilla;   Agencia Sanitaria Bajo Guadalquivir
Recruiting

Interest of the Smartphone Application "MonCœur" in the Follow-up of Patients With Heart Failure

Conditions:   Heart Failure;   Heart Decompensation
Intervention:   Device: APPLI
Sponsor:   French Cardiology Society
Not yet recruiting

PACIFIC-PRESERVED : PhenomApping, ClassIFication, and Innovation for Cardiac Dysfunction - HF With PRESERVED LVEF Study

Conditions:   Heart Failure;   Heart Failure With Preserved Ejection Fraction
Intervention:   Other: Extensive phenotyping
Sponsors:   Assistance Publique - Hôpitaux de Paris;   BPIfrance;   Sanofi;   Institut de Recherches Internationales Servier;   Institut National de la Santé Et de la Recherche Médicale, France;   BioSerenity;   Casis;   Firalis SA;   Fealinx;   Centre National de la Recherche Scientifique, France;   ESPCI Paris;   University of Paris 5 - Rene Descartes;   Sorbonne Université
Not yet recruiting

The Transition From Hypertension to Hypertensive Heart Disease and Heart Failure, the PREFERS Hypertension Study

Conditions:   Hypertension;   Heart Failure;   Hypertensive Heart Disease;   Diastolic Dysfunction
Intervention:  
Sponsor:   Karolinska Institutet
Enrolling by invitation

Short-term Effects of Dapagliflozin on Peak VO2 in HFrEF

Conditions:   Heart Failure With Reduced Ejection Fraction;   Type 2 Diabetes
Interventions:   Diagnostic Test: Maximal functional capacity by cardiopulmonary exercise testing;   Diagnostic Test: Echocardiography;   Behavioral: Evaluation of quality of life health related;   Diagnostic Test: Submáximal functional capacity assesment by 6 minutes walk test
Sponsor:   Fundación para la Investigación del Hospital Clínico de Valencia
Recruiting

Evaluating Mobile Health Tool Use for Capturing Patient-centered Outcomes Measures in HF Patients

Condition:   Heart Failure
Intervention:  
Sponsors:   Biofourmis Singapore Pte Ltd.;   Food and Drug Administration (FDA);   Mayo Clinic
Not yet recruiting

The Persistence of Autoantibody Neutralisation by BC 007 in Patients With Chronic HFrEF and Autoantibodies Against the Beta1-Adrenergic Receptor

Conditions:   Cardiomyopathy, Dilated;   Heart Failure;   Autoantibodies
Intervention:   Drug: BC 007
Sponsor:   Berlin Cures GmbH
Recruiting

Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study

Condition:   Stage D Heart Failure
Interventions:   Drug: Sacubitril-Valsartan;   Drug: Usual care (standard-of-care) arm
Sponsor:   The Cleveland Clinic
Recruiting

The Effects of Exercise Therapy for Craniocervical and Cervicothoracic Muscles on Non-specific Neck Pain.

Conditions:   Neck Pain;   Chronic Pain
Intervention:   Other: Neck extensors training versus deep cervical flexors training, compared to a control group.
Sponsor:   University of Jaén
Recruiting

Cardiovascular Outcomes SGLT-2 Inhibitors Versus GLP-1 Receptor Agonists

Condition:   Type 2 Diabetes
Interventions:   Drug: SGLT2 inhibitor;   Drug: GLP-1 receptor agonist
Sponsor:   University of Padova
Completed

A Post Market Surveillance Study of the Hemovent Extracorporeal Cardiopulmonary Support System of Cardiac and Respiratory Support: The MOBYBOX Trial

Conditions:   Cardiac Failure;   Respiratory Failure;   Cardio-Respiratory Failure
Intervention:   Device: MOBYBOX System
Sponsors:   Hemovent GmbH;   MAXIS Medical, LLC
Not yet recruiting

RV Systolic and Diastolic Function and Contractile Reserve Under Acute Exercise and in Response to Chronic Exercise-based Rehabilitation

Conditions:   Pulmonary Hypertension;   Right Heart Failure;   Heart Failure;   Contractility;   RV-arterial Coupling
Intervention:   Other: Exercise
Sponsor:   University of Giessen
Not yet recruiting

Re-Energize Fontan

Condition:   Single-ventricle
Interventions:   Other: Live-Video-Supervised Exercise Intervention;   Other: Usual Care then Live-Video Supervised Exercise Intervention
Sponsors:   Stanford University;   The Methodist Hospital System
Not yet recruiting

China Q Cohort Study

Conditions:   End Stage Renal Disease on Dialysis;   Peritoneal Dialysis;   Hemodialysis
Intervention:   Other: Dialysis modality
Sponsor:   Sun Yat-sen University
Not yet recruiting

Effects of empagliFlozin on myocardIal metabOlic Rate of glucosE Estimated Through 18FDG PET (FIORE Study)

Conditions:   Type 2 Diabetes;   Cardiovascular Risk Factor
Interventions:   Drug: Empagliflozin 10 MG;   Drug: Glimepiride 2 mg
Sponsor:   University of Catanzaro
Recruiting

Pulsed Field Ablation to Irreversibly Electroporate Tissue and Treat AF

Condition:   Atrial Fibrillation
Intervention:   Device: Medtronic Pulsed Field Ablation (PFA) System
Sponsor:   Medtronic Cardiac Rhythm and Heart Failure
Not yet recruiting

Effect of Sacubitril/Valsartan on Reduced Right Ventricular Ejection Fraction in Patients With CTD

Conditions:   Myocardial Injury;   Connective Tissue Diseases
Intervention:   Drug: Sacubitril / Valsartan Oral Tablet
Sponsor:   RenJi Hospital
Not yet recruiting

Impact of the Transpulmonary Pressure on Right Ventricle Function in Acute Respiratory Distress Syndrome

Condition:   Acute Respiratory Distress Syndrome
Interventions:   Other: Pneumotachograph;   Other: Esophageal catheter;   Other: Transthoracic and / or transesophageal cardiac ultrasound
Sponsor:   Assistance Publique - Hôpitaux de Paris
Not yet recruiting

Diuretics and Volume Overload in Early CKD

Condition:   Chronic Kidney Disease
Intervention:   Drug: Diuretic initiation or augmentation
Sponsor:   VA Office of Research and Development
Not yet recruiting

Tonometry(1) and Duplex Ultrasound(2) to Predict CV Events in to be Treated Patients With an AAA

Conditions:   Abdominal Aortic Aneurysm;   Cardiovascular Events
Interventions:   Diagnostic Test: Carotid Artery Reactivity test (CAR test);   Diagnostic Test: Arterial Stiffness
Sponsors:   Rijnstate Hospital;   Radboud University;   Canisius-Wilhelmina Hospital
Not yet recruiting

Medical-economic Evaluation Comparing Intensive Outpatient Monitoring of Neuro-cardiovascular Diseases by Nurses, Doctors and Hospital and Private-sector Pharmacists, Compared to Usual Monitoring.

Conditions:   Cerebrovascular Accidents;   Myocardial Infarction
Interventions:   Other: Usual follow-up;   Other: Intensive follow-up
Sponsor:   Centre Hospitalier Universitaire Dijon
Not yet recruiting

Apple Heart & Movement Study

Condition:   Prevention
Intervention:   Diagnostic Test: Predictors of events
Sponsors:   Brigham and Women's Hospital;   Apple Inc.;   American Heart Association
Recruiting

Adherence to Drug Therapy in Patients With HFrEF During Inpatient Rehabilitation and After at 3 and 6-months.

Condition:   Adherence to Drug Therapy in Patients With HFrEF
Intervention:  
Sponsors:   Paracelsus Harz Clinic Bad Suderode.;   KKS Netzwerk
Recruiting

Efficacy and Safety Of Alirocumab to Prevent Early Cardiac Allograft Vasculopathy in Recent Heart Transplant Recipients

Condition:   Cardiac Allograft Vasculopathy
Interventions:   Drug: Alirocumab;   Other: Placebo
Sponsors:   Institute for Clinical and Experimental Medicine;   St. Anne's University Hospital Brno, Czech Republic;   Centre of Cardiovascular and Transplantation Surgery, Czech Republic
Recruiting

Comparison of Radial and Ulnar Artery Intervention in Patients With ST Elevated Myocardial Infarction

Condition:   ST Elevated Myocardial Infarction
Intervention:   Procedure: primary percutaneous coronary intervention
Sponsors:   Sakarya University;   Cosansu, Kahraman, M.D.
Recruiting

Feasibility Study of a Non-invasive Device to Quickly, Easily and Accurately Measure Respiration in a Clinical Setting

Condition:   COPD
Intervention:   Device: Device
Sponsors:   Changi General Hospital;   Agency for Science, Technology and Research
Recruiting

Signature of the Risk Profile of Mortality in a Hospital Cohort of Patients With Metabolic Diseases

Condition:   Metabolic Disease
Intervention:  
Sponsor:   University Hospital, Lille
Not yet recruiting

Assessment of ECMO in Acute Myocardial Infarction Cardiogenic Shock

Conditions:   Acute Myocardial Infarction;   Cardiogenic Shock
Intervention:   Device: VA-ECMO
Sponsor:   Assistance Publique - Hôpitaux de Paris
Not yet recruiting

Myocardial Infarction With Non-Obstructive Coronary Arteries in the Greek Population

Conditions:   Acute Myocardial Infarction;   Non-Obstructive Coronary Atherosclerosis;   Ischemic Heart Disease;   Angina Pectoris;   Coronary Microvascular Disease
Interventions:   Other: MINOCA registry;   Diagnostic Test: CCTA Phenotypes
Sponsor:   AHEPA University Hospital
Not yet recruiting

Multi-center Application of Bivalirudin in Left Atrial Appendage Occlusion

Condition:   Evaluate the Safety and Efficacy of Bivalirudin in Decreasing Bleeding Risk
Interventions:   Drug: Bivalirudin;   Drug: Heparin
Sponsor:   Shanghai Zhongshan Hospital
Not yet recruiting

Characterizing Chemo-Radiotherapy Treatment-Related Cardiac Changes in Non-metastatic, Non-recurrent Lung and Esophageal Cancer Patients

Conditions:   Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8;   Clinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8;   Clinical Stage I Esophageal Adenocarcinoma AJCC v8;   Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8;   Clinical Stage II Esophageal Adenocarcinoma AJCC v8;   Clinical Stage II Esophageal Squamous Cell Carcinoma AJCC v8;   Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8;   Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8;   Clinical Stage III Esophageal Adenocarcinoma AJCC v8;   Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8;   Non-Metastatic Lung Carcinoma;   Pathologic Stage 0 Esophageal Adenocarcinoma AJCC v8;   Pathologic Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8;   Pathologic Stage I Esophageal Adenocarcinoma AJCC v8;   Pathologic Stage I Esophageal Squamous Cell Carcinoma AJCC v8;   Pathologic Stage IA Esophageal Adenocarcinoma AJCC v8;   Pathologic Stage IA Esophageal Squamous Cell Carcinoma AJCC v8;   Pathologic Stage IB Esophageal Adenocarcinoma AJCC v8;   Pathologic Stage IB Esophageal Squamous Cell Carcinoma AJCC v8;   Pathologic Stage IC Esophageal Adenocarcinoma AJCC v8;   Pathologic Stage II Esophageal Adenocarcinoma AJCC v8;   Pathologic Stage II Esophageal Squamous Cell Carcinoma AJCC v8;   Pathologic Stage IIA Esophageal Adenocarcinoma AJCC v8;   Pathologic Stage IIA Esophageal Squamous Cell Carcinoma AJCC v8;   Pathologic Stage IIB Esophageal Adenocarcinoma AJCC v8;   Pathologic Stage IIB Esophageal Squamous Cell Carcinoma AJCC v8;   Pathologic Stage III Esophageal Adenocarcinoma AJCC v8;   Pathologic Stage III Esophageal Squamous Cell Carcinoma AJCC v8;   Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC v8;   Pathologic Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8;   Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8;   Pathologic Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8;   Postneoadjuvant Therapy Stage I Esophageal Adenocarcinoma AJCC v8;   Postneoadjuvant Therapy Stage I Esophageal Squamous Cell Carcinoma AJCC v8;   Postneoadjuvant Therapy Stage II Esophageal Adenocarcinoma AJCC v8;   Postneoadjuvant Therapy Stage II Esophageal Squamous Cell Carcinoma AJCC v8;   Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC v8;   Postneoadjuvant Therapy Stage III Esophageal Squamous Cell Carcinoma AJCC v8;   Postneoadjuvant Therapy Stage IIIA Esophageal Adenocarcinoma AJCC v8;   Postneoadjuvant Therapy Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8;   Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC v8;   Postneoadjuvant Therapy Stage IIIB Esophageal Squamous Cell Carcinoma AJCC v8;   Stage 0 Lung Cancer AJCC v8;   Stage I Lung Cancer AJCC v8;   Stage IA1 Lung Cancer AJCC v8;   Stage IA2 Lung Cancer AJCC v8;   Stage IA3 Lung Cancer AJCC v8;   Stage IB Lung Cancer AJCC v8;   Stage II Lung Cancer AJCC v8;   Stage IIA Lung Cancer AJCC v8;   Stage IIB Lung Cancer AJCC v8;   Stage III Lung Cancer AJCC v8;   Stage IIIA Lung Cancer AJCC v8;   Stage IIIB Lung Cancer AJCC v8;   Stage IIIC Lung Cancer AJCC v8
Interventions:   Procedure: Biospecimen Collection;   Device: Cardiac Event Monitor;   Other: Chemoradiotherapy;   Radiation: Radiation Therapy
Sponsors:   Mayo Clinic;   National Cancer Institute (NCI)
Recruiting

The Elixir Bioadaptor vs. The Onyx Stent in De Novo Native Coronary Arteries

Condition:   Coronary Artery Disease
Intervention:   Device: stenting
Sponsor:   Elixir Medical Corporation
Not yet recruiting

Extended Care in High-Risk Surgical Patient (EXCARE) Pathway in High-risk Surgical Population

Conditions:   Postoperative Complications;   Patient Care Team
Interventions:   Behavioral: Postoperative Monitoring;   Diagnostic Test: High-sensitivity cardiac troponin testing
Sponsor:   Hospital de Clinicas de Porto Alegre
Recruiting

Right Ventricular Pacing in Pulmonary Arterial Hypertension

Conditions:   Pulmonary Artery Hypertension;   Right Ventricular Dysfunction
Intervention:   Procedure: Temporary right ventricular pacing
Sponsor:   University of California, San Francisco
Not yet recruiting

Team Clinic: Expansion of an Innovative Multi-Disciplinary Care Model for Adolescents With Type 1 Diabetes

Condition:   Type1 Diabetes
Intervention:   Other: Team Clinic
Sponsors:   Children's Hospital Los Angeles;   University of Colorado Denver School of Medicine Barbara Davis Center;   Cedars-Sinai Medical Center
Not yet recruiting