Heart Failure

Clinical Trial Finder

Many patients with heart failure are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Safety and Tolerability of In-hospital Initiation of LCZ696 Compared to Valsartan in HFpEF Patients With Acute Decompensated Heart Failure (ADHF) Who Have Been Stabilized During Hospitalization (PARAGLIDE-HF)

Condition:   Heart Failure With Preserved Ejection Fraction (HFpEF)
Interventions:   Drug: sacubitril/valsartan;   Drug: valsartan
Sponsor:   Novartis Pharmaceuticals
Not yet recruiting

A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart Failure

Condition:   Systolic Heart Failure
Interventions:   Drug: Eplerenone;   Drug: Spironolactone
Sponsors:   Bispebjerg Hospital;   Rigshospitalet, Denmark
Not yet recruiting

Improving Self-care of Heart Failure Caregivers

Condition:   Heart Failure
Intervention:   Behavioral: ViCCY
Sponsor:   University of Pennsylvania
Not yet recruiting

Comparing Diuretic Strategies in Hospitalized Heart Failure

Condition:   Heart Failure
Intervention:   Drug: Loop Diuretics vs. loop + thiazide diuretics
Sponsors:   Stanford University;   American Heart Association
Not yet recruiting

Peritoneal Ultrafiltration in Cardio Renal Syndrome.

Condition:   Congestive Heart Failure
Interventions:   Drug: PolyCore (Polydextrin, L-Carnitine, D-xylitol);   Drug: Medical therapy including loop diuretic (furosemide) daily dose up to 2.5 mg/kg/day,
Sponsor:   CoreQuest, Switzerland
Not yet recruiting

MRI Assessment of Pulmonary Edema in Acute Heart Failure

Conditions:   Acute Heart Failure;   Pulmonary Edema With Heart Failure
Intervention:   Diagnostic Test: MRI
Sponsors:   University of Alberta;   Canadian Institutes of Health Research (CIHR)
Not yet recruiting

Sodium Intake in Failing Heart Patients.

Conditions:   Heart Failure;   Salt; Edema
Intervention:   Other: restricted dietary salt intake
Sponsor:   University of Campania "Luigi Vanvitelli"

The COmPLETE Study

Conditions:   Aging;   Heart Failure
Intervention:   Behavioral: Physical Activity
Sponsor:   Arno Schmidt-Trucksäss

Early Detection of Autoimmune Thyroid Heart Disease Via Urinary Exosomal Proteins

Conditions:   Thyroid Diseases;   Heart Failure
Sponsor:   National Taiwan University Hospital
Not yet recruiting

Influence of Individualized Training on Cardiopulmonary Exercise Capacity in LVAD Patients

Condition:   Heart Failure
Sponsor:   Heart and Diabetes Center North-Rhine Westfalia
Not yet recruiting

A Study AnalyZing a NovEl Wearable SeNsor for Remote PatIent Health Monitoring

Conditions:   Heart Failure;   Chronic Kidney Diseases
Interventions:   Device: CorBand;   Other: Activity Monitor;   Other: Bioimpedance spectrometer;   Other: ECG;   Other: respiratory rate sensor
Sponsors:   ReThink Medical;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation

A Study of Low-dose Intracoronary Thrombolytic Therapy in STEMI (Heart Attack) Patients.

Conditions:   STEMI;   Elevated IMR (>32)
Interventions:   Drug: Tenecteplase;   Other: Sterile water
Sponsor:   University of Sydney

MOMENTUM 3 Pivotal Cohort Extended Follow-up PAS

Condition:   Advanced Refractory Left Ventricular Heart Failure
Intervention:   Device: HM3 LVAS
Sponsor:   Abbott Medical Devices
Enrolling by invitation

HARapan kiTa ECP (External Counter Pulsation) Study HARTEC Study

Conditions:   Cardiac Rehabilitation;   Angiogenesis;   Refractory Angina
Intervention:   Device: External Counter Pulsation (ECP) therapy
Sponsor:   National Cardiovascular Center Harapan Kita Hospital Indonesia
Not yet recruiting

Left Atrial Appendage Occlusion in Patients With Non-valvular Atrial Fibrillation From Shanghai

Conditions:   Atrial Fibrillation;   Left Atrial Appendage Occlusion
Intervention:   Device: left atrial appendage occlusion devices
Sponsor:   Shanghai 10th People's Hospital

Iron in Patients With Cardiovascular Disease

Conditions:   Cardiovascular Diseases;   Anemia, Iron-deficiency;   Acute Myocardial Infarction;   Atrial Fibrillation;   Systolic Heart Failure
Interventions:   Drug: Ferric carboxymaltose;   Drug: Saline
Sponsor:   Dr. med. Mahir Karakas

Prevention of New Onset AF After TAVI (PAF-TAVI Trial)

Condition:   Atrial Fibrillation New Onset
Intervention:   Procedure: transcatheter aortic valve implantation
Sponsor:   Luis Nombela Franco
Not yet recruiting

Tonometry and Duplex Ultrasound to Predict AAA Progression and CV Events in Aneurysm Patients (1-2-3 Trial)

Conditions:   Abdominal Aortic Aneurysm;   Cardiovascular Events
Interventions:   Diagnostic Test: Carotid Artery Reactivity test (CAR test);   Diagnostic Test: Arterial stiffness
Sponsors:   Rijnstate Hospital;   Radboud University;   Canisius-Wilhelmina Hospital
Not yet recruiting

A Study Using Medical Records of Danish People With Type 2 Diabetes Comparing Empagliflozin and Liraglutide in the Occurrence of Serious Cardiovascular Disease

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Empagliflozin;   Drug: Liraglutide
Sponsor:   Boehringer Ingelheim

EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality

Conditions:   Atrial Fibrillation;   Coronary Heart Disease;   Cardiovascular Diseases;   Heart Failure;   Hypertension;   Peripheral Arterial Disease;   Stroke, Ischemic;   Asthma;   Chronic Obstructive Pulmonary Disease;   Obesity;   Cancer;   Chronic Kidney Diseases;   Diabetes Mellitus;   Dementia;   Depression;   Epilepsy;   Mental Health Disorder;   Rheumatoid Arthritis;   Blood Pressure
Sponsor:   Future Genetics Limited
Not yet recruiting

Cardiovascular Magnetic Resonance GUIDEd Insertion of Implantable Cardiac Defibrillator in Dilated CardioMyopathy

Conditions:   Dilated Cardiomyopathy;   Left Ventricular Systolic Dysfunction;   Fibrosis Myocardial
Interventions:   Device: ICD;   Device: ILR
Sponsor:   Flinders University
Not yet recruiting

Efficacy and Safety Evaluation of PC-SOD for Injection in Reducing Myocardial Reperfusion Injury

Condition:   Myocardial Reperfusion Injury
Interventions:   Drug: PC-SOD;   Drug: placebo
Sponsors:   Beijing Tide Pharmaceutical Co., Ltd;   Peking University First Hospital
Not yet recruiting

Research of Burden of Interstititial Lung Diseases in Turkey

Conditions:   Lung Diseases, Interstitial;   Fibrosis Lung
Sponsor:   Karadeniz Technical University
Active, not recruiting

Standard-dose Apixaban AFtEr Very Low-dose ThromboLYSis for Acute Intermediate-high Risk Acute Pulmonary Embolism

Conditions:   Pulmonary Embolism With Acute Cor Pulmonale;   Pulmonary Embolism;   Pulmonary Embolism With Pulmonary Infarction;   Pulmonary Embolism Subacute Massive;   Right Ventricular Dysfunction;   Right Ventricular Failure
Interventions:   Drug: Alteplase;   Drug: Unfractionated heparin;   Drug: Placebo;   Drug: Apixaban
Sponsors:   Victor Tapson, MD;   Bristol-Myers Squibb
Not yet recruiting

Neuromodulation to Regulate Inflammation and Autonomic Imbalance in Sepsis

Condition:   Septic Shock
Intervention:   Device: Low Level Transcutaneous Vagus Nerve Stimulation
Sponsors:   University of Oklahoma;   Oklahoma City VA Medical Center
Not yet recruiting

Comparison of Two Methods for Assessing Cough Capacity in Intensive Care Unit After Cardiac Surgery

Conditions:   Intensive Care Unit;   Cardiac Surgery
Sponsor:   Centre Chirurgical Marie Lannelongue

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