Heart Attack

Clinical Trial Finder

Many patients with heart disease are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Prospective Outpatient Registry of Myocardial Infarction Patients

Condition:   Myocardial Infarction
Intervention:  
Sponsor:   National Research Center for Preventive Medicine
Active, not recruiting

Optimal Coronary Flow After PCI for Myocardial Infarction - a Pilot Study

Condition:   ST-segment Elevation Myocardial Infarction
Interventions:   Drug: alteplase;   Drug: Placebo
Sponsor:   Vastra Gotaland Region
Recruiting

Troponin POCT in the Diagnosis of an Acute Myocardial Infarction

Conditions:   Acute Myocardial Infarction;   Troponin
Intervention:   Diagnostic Test: Blood analysis
Sponsor:   Ziekenhuis Oost-Limburg
Completed

A Study to Evaluate the Safety and Efficacy of MEDI6012 in Acute ST Elevation Myocardial Infarction

Condition:   ST Elevation Myocardial Infarction
Interventions:   Biological: MEDI6012;   Other: Placebo
Sponsors:   MedImmune LLC;   Thrombolysis in Myocardial Infarction (TIMI) Study Group
Recruiting

Early Initiation of Low Dose Tirofiban for PPCI in STEMI Patients.

Condition:   ST Elevation Myocardial Infarction
Interventions:   Drug: Tirofiban;   Drug: Normal saline
Sponsor:   Shanghai Zhongshan Hospital
Recruiting

COlchicine for Left VEntricular Remodeling Treatment in Acute Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Drug: Colchicine group (experimental arm);   Drug: Placebo group (control arm)
Sponsor:   Hospices Civils de Lyon
Recruiting

Impact of Daylight on Patients With Acute Myocardial Infarction

Conditions:   Coronary Arteriosclerosis;   Myocardial Infarction
Interventions:   Other: Day Light;   Other: Room Light
Sponsor:   University of Colorado, Denver
Recruiting

Rehabilitation in the Home Setting for Older Adults In the Early Period After Myocardial Infarction

Condition:   Acute Myocardial Infarction (AMI)
Interventions:   Behavioral: Home-based physical therapy;   Behavioral: Usual Care
Sponsor:   NYU Langone Health
Completed

The Harefield Acute Myocardial Infarction Cohort

Condition:   Acute Coronary Syndrome
Intervention:   Other: 60mls of blood donated for research analysis
Sponsor:   Royal Brompton & Harefield NHS Foundation Trust
Recruiting

SONOthrombolysis in Patients With an ST-segment Elevation Myocardial Infarction With fibrinoLYSIS (SONOSTEMI-LYSIS) Trial

Condition:   ST Elevation Myocardial Infarction
Intervention:   Drug: Definity® with High Mechanical Index Ultrasound
Sponsors:   University of Alberta;   Canadian VIGOUR Centre
Not yet recruiting

Randomized, Single Center Study About the Impact of an E-learning Dedicated to Myocardial Infarction Patient

Condition:   Acute Myocardial Infarction
Intervention:   Other: E-learning
Sponsor:   University of Lausanne Hospitals
Active, not recruiting

Automated Hovering to Improve Medication Adherence Among Myocardial Infarction Patients (Heartstrong)

Condition:   Patients With Principal or Secondary Diagnosis Code of Intrntl Classification of Diseases, 9th Revision, (ICD-9-CM) 410 (Except When 5th Digit Was 2)
Intervention:   Behavioral: Electronic Pill Bottle, Incentives, Social Influence
Sponsor:   University of Pennsylvania
Completed

Two- Dimensional Speckle Tracking Echocardiography After Primary Percutaneous Coronary Intervention

Condition:   Myocardial Infarction
Intervention:   Procedure: 2D speckle tracking echocardiography
Sponsor:   Assiut University
Not yet recruiting

iFR-guided Revascularization in STEMI

Condition:   ST Segment Elevation Myocardial Infarction
Intervention:  
Sponsor:   Azienda Ospedaliera San Camillo Forlanini
Recruiting

Technical Development of Cardiovascular Magnetic Resonance Imaging

Conditions:   Cardiomyopathy;   Congenital Heart Disease;   Cardiovascular Disease;   Cardiac Magnetic Resonance Imaging;   Acute Myocardial Infarction
Intervention:   Device: Siemens MRI scanner
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Suspended

Phase II Clinical Trial of Percutaneous Ventricular Restoration Using Heartech® Device Preventing Heart Failure Post Myocardial Infarction (The Partical Study)

Condition:   Efficacy, Safty, Device
Intervention:   Device: percutaneous ventricular restoration using heartech® device
Sponsor:   Shanghai Jiao Tong University School of Medicine
Recruiting

ECG Methods for the Prompt Identification of Coronary Events

Conditions:   Chest Pain;   Myocardial Infarction;   Myocardial Ischemia;   Acute Coronary Syndrome
Intervention:  
Sponsors:   University of Pittsburgh;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Diagnostic Accuracy of Electrocardiogram for Acute Coronary Occlusion Resulting in Myocardial Infarction

Conditions:   Myocardial Infarction;   Acute Coronary Syndrome;   Coronary Artery Disease
Intervention:   Radiation: Coronary angiogram
Sponsors:   Yeditepe University;   Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital
Recruiting

ACS Registry - A Non-interventional Study to Estimate the Rates of Outcomes in ACS Patients in Moscow

Conditions:   Heart Attack;   Stroke;   Cardiovascular Death
Intervention:  
Sponsor:   AstraZeneca
Recruiting

SP16 Inflammatory Response Inhibition Trial

Conditions:   Myocardial Infarction;   Inflammation
Intervention:   Drug: SP16
Sponsors:   Virginia Commonwealth University;   Serpin Pharma, LLC
Not yet recruiting

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention & Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Population Health Research Institute;   Janssen Research & Development, LLC
Active, not recruiting

Inflammation and Cardiovascular Health in Women

Conditions:   HIV/AIDS;   Myocardial Infarction
Interventions:   Radiation: Cardiac PET;   Radiation: 99mTc-tilmanocept SPECT/CT;   Radiation: Contrast Enhanced Coronary and Aortic Computed Tomography Angiography
Sponsors:   Massachusetts General Hospital;   National Institutes of Health (NIH)
Recruiting

Multicenter Registry for Angiography-Derived Quantitative Flow Ratio

Condition:   Ischemic Heart Disease
Intervention:   Diagnostic Test: QFR assessment
Sponsors:   Samsung Medical Center;   Seoul National University Hospital;   Inje University;   Dongsan Medical Center;   Chosun University Hospital
Active, not recruiting

Brilinta Clinical Experience Investigation

Condition:   Acute Coronary Syndrome, Old Myocardial Infarction
Intervention:  
Sponsor:   AstraZeneca
Recruiting

The British Heart Foundation SENIOR-RITA Trial

Condition:   NSTEMI - Non-ST Segment Elevation MI
Interventions:   Procedure: Coronary Angiography;   Procedure: Coronary revascularisation;   Other: Optimal Medical Therapy
Sponsors:   Newcastle-upon-Tyne Hospitals NHS Trust;   British Heart Foundation;   Newcastle University
Recruiting

Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)

Condition:   Atherosclerosis
Interventions:   Drug: Canakinumab;   Drug: Placebo;   Drug: Standard of care
Sponsor:   Novartis Pharmaceuticals
Completed

Improve SCA Bridge Study

Conditions:   Sudden Cardiac Arrest;   Acute Myocardial Infarction
Interventions:   Behavioral: EP referred group;   Behavioral: Non-Referred group
Sponsor:   Medtronic Cardiac Rhythm and Heart Failure
Recruiting

Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors and Risk of Cardiovascular Events

Conditions:   Type2 Diabetes;   Myocardial Infarction;   Ischemic Stroke;   Cardiovascular Death;   Heart Failure;   All-Cause Mortality
Interventions:   Drug: Sodium-glucose cotransporter 2 (SGLT2) inhibitors;   Drug: Dipeptidyl peptidase-4 (DPP-4) inhibitors
Sponsors:   Canadian Network for Observational Drug Effect Studies, CNODES;   Drug Safety and Effectiveness Network, Canada;   Canadian Institutes of Health Research (CIHR)
Completed

Disrupt CAD IV With the Shockwave Coronary IVL System

Conditions:   Coronary Artery Disease;   Myocardial Infarction
Intervention:   Device: Lithotripsy
Sponsor:   Shockwave Medical, Inc.
Recruiting

PeriOperative ISchemic Evaluation-3 Trial

Conditions:   Perioperative Bleeding;   Venous Thrombosis;   Arterial Thrombosis
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo (Saline);   Other: Perioperative hypotension-avoidance strategy;   Other: Perioperative hypertension-avoidance strategy
Sponsor:   Population Health Research Institute
Recruiting

The MICHI NEUROPROTECTION SYSTEM: Evaluation of Performance in Carotid Artery Stent Procedures (The LOTUS Study)

Conditions:   Carotid Stenosis;   Carotid Artery Disease
Intervention:   Device: MICHI Neuroprotection System
Sponsor:   Silk Road Medical
Completed

Testing a Community Intervention to Increase Aspirin Use

Conditions:   Myocardial Infarction;   Stroke
Interventions:   Other: Mass Media plus clinic intervention.;   Other: Media
Sponsor:   University of Minnesota
Recruiting

The Cardiovascular Multi-dimensional Observational Investigation of the Use of PCSK9 Inhibitors (cvMOBIUS)

Condition:   ASCVD
Intervention:  
Sponsors:   Amgen;   Duke Clinical Research Institute
Recruiting

Personalized Vs. Standard Duration of Dual Antiplatelet Therapy and New-generation Polymer-Free vs- Biodegradable-Polymer DES

Conditions:   Coronary Artery Disease;   Acute Coronary Syndrome;   Chronic Coronary Syndrome;   Myocardial Infarction
Interventions:   Device: Percutaneous coronary intervention with implantation of amphilimus-eluting stents for coronary artery disease.;   Device: Percutaneous coronary intervention with implantation of everolimus-eluting stents for coronary artery disease.;   Drug: Personalized DAPT duration;   Drug: Standard DAPT duration
Sponsors:   Federico II University;   AdvicePharma Group
Recruiting

Systematic Assessment and Targeted Improvement of Services Following Yearlong Surgical Outcomes Surveys

Conditions:   Heart Attack;   Cardiac Arrest;   Congestive Heart Failure;   Atrial Fibrillation;   Angina;   Deep Vein Thrombosis;   Pulmonary Embolism;   Respiratory Arrest;   Respiratory Failure;   Pneumonia;   Gastrointestinal Bleed;   Stomach Ulcer;   Delirium;   Stroke;   Nerve Injury;   Surgical Wound Infection
Intervention:  
Sponsor:   Washington University School of Medicine
Active, not recruiting

The Bern Heart and Brain Interaction Study - Interaction Between Brain and Heart in Acute Ischemic Stroke

Condition:   Acute Stroke
Interventions:   Procedure: Short cardiovascular MRI (CMR);   Procedure: Adenosine-perfusion cardiovascular MRI (CMR);   Procedure: Blood draw;   Procedure: Urine (collection over 24h)
Sponsor:   University Hospital Inselspital, Berne
Recruiting

Identification of Genomic Predictors of Adverse Events After Cardiac Surgery

Conditions:   Heart; Dysfunction Postoperative, Cardiac Surgery;   Genetic Predisposition to Disease;   Atrial Fibrillation;   Myocardial Infarction;   Heart Failure
Intervention:  
Sponsors:   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI);   Texas Heart Institute;   University of Texas Southwestern Medical Center
Recruiting

Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD

Condition:   Coronary Artery Disease
Interventions:   Drug: High dose potent statin;   Drug: ACE-I (lisinopril) or ARB (losartan);   Drug: Aspirin;   Behavioral: Lifestyle Counseling;   Behavioral: Quality of Life Questionnaires
Sponsors:   University of Florida;   United States Department of Defense
Recruiting

Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Biological: Apolipoprotein A-I [human] (apoA-I);   Other: Placebo
Sponsor:   CSL Behring
Recruiting

Evaluation of the First, Second, and New Drug-Eluting Stents in Routine Clinical Practice

Conditions:   Coronary Artery Disease;   Percutaneous Transluminal Coronary Angioplasty
Intervention:  
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea
Recruiting

Prehospital Risk Stratification in Acute Coronary Syndromes

Conditions:   Acute Coronary Syndrome;   Non-ST Elevation Myocardial Infarction (nSTEMI)
Interventions:   Diagnostic Test: Ultrasound;   Diagnostic Test: Troponin- T quick test
Sponsors:   Sorlandet Hospital HF;   Norwegian Air Ambulance Foundation
Completed

Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity

Conditions:   Overweight;   Obesity
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

Ischemic Conditioning in STEMI Patients

Condition:   Cardiac Arrest
Intervention:   Procedure: Remote post-ischemic conditioning
Sponsor:   Beth Israel Deaconess Medical Center
Active, not recruiting

Cardiovascular Outcomes Following Ertugliflozin Treatment in Type 2 Diabetes Mellitus Participants With Vascular Disease, The VERTIS CV Study (MK-8835-004)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Ertugliflozin;   Drug: Placebo
Sponsors:   Merck Sharp & Dohme Corp.;   Pfizer
Completed

XIENCE 28 Global Study

Conditions:   Bleeding Disorder;   Stroke, Ischemic;   Stroke Hemorrhagic;   Hematological Disease;   Thrombocytopenia;   Coagulation Disorder;   Anemia;   Renal Insufficiency;   Coronary Artery Disease
Interventions:   Device: XIENCE;   Drug: DAPT
Sponsor:   Abbott Medical Devices
Active, not recruiting

Stepwise Approach To sUbstrate Modification for Ventricular Tachycardia

Conditions:   Ventricular Tachycardia;   Catheter Ablation;   Tachycardia, Ventricular
Intervention:   Procedure: catheter-based ablation
Sponsors:   Vivek Reddy;   Biosense Webster, Inc.
Terminated

Non-Interventional Study on Effectiveness of Elxaban Tab. in Patients With Non-valvular Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Yonsei University
Recruiting

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Condition:   Hypertension
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

Comparison of Saphenous Vein Harvesting by Endoscopic Versus Open Conventional Methods

Condition:   Coronary Artery Disease
Interventions:   Device: Endoscopic vein harvest;   Other: Open vein harvest
Sponsor:   Sheba Medical Center
Recruiting

The Effect of GRAVITY on Physiological Measurements During Invasive Coronary Angiography and Intervention

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   Basildon and Thurrock University Hospitals NHS Foundation Trust;   Anglia Ruskin University
Completed

Yorkshire Enhanced Stop Smoking Study

Conditions:   Cancer, Lung;   Respiratory Disease;   Heart Diseases
Interventions:   Other: Intervention;   Other: Usual Care
Sponsors:   University of Nottingham;   The Leeds Teaching Hospitals NHS Trust;   University of Leeds;   Cardiff University;   University of Manchester;   University College, London;   University of York;   Yorkshire Cancer Research
Recruiting

XIENCE 28 USA Study

Conditions:   Bleeding Disorder;   Ischemic Stroke;   Hemorrhagic Stroke;   Hematological Diseases;   Thrombocytopenia;   Coagulation Disorder;   Anemia;   Renal Insufficiency;   Coronary Artery Disease
Interventions:   Device: XIENCE;   Drug: DAPT (aspirin and/or P2Y12 receptor inhibitor)
Sponsor:   Abbott Medical Devices
Recruiting

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Global Study Comparing a rivAroxaban-based Antithrombotic Strategy to an antipLatelet-based Strategy After Transcatheter aortIc vaLve rEplacement to Optimize Clinical Outcomes

Condition:   Transcatheter Aortic Valve Replacement
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Acetylsalicylic Acid (ASA);   Drug: Clopidogrel;   Drug: Vitamin K antagonist (VKA)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Terminated

Safety of Inhaled Hydrogen Gas Mixtures in Healthy Volunteers

Condition:   Healthy
Intervention:   Drug: Hydrogen
Sponsor:   Boston Children’s Hospital
Not yet recruiting

Understanding the Exercise-Hypertension Paradox

Condition:   Hypertension
Interventions:   Dietary Supplement: Oral Antioxidant;   Other: Exercise rehabilitation
Sponsor:   VA Office of Research and Development
Recruiting

Role of PPAR-y Agonists in Immunomodulation and Vascular Prevention in SLE (PPAR-SLE)

Condition:   Systemic Lupus Erthematosus
Interventions:   Radiation: PET/CT;   Drug: Pioglitazone
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Active, not recruiting

Efficacy and Safety of Implantable Cardioverter-Defibrillator (ICD) Implantation in the Elderly

Conditions:   Cardiomyopathy;   Coronary Artery Disease;   Congestive Heart Failure;   Myocardial Infarction
Interventions:   Device: Implantable Cardioverter Defibrillator;   Other: Optimal Medical Therapy
Sponsor:   VA Office of Research and Development
Active, not recruiting

Cardiovascular Evaluation of Patients With High Cholesterol and Normal Volunteers

Condition:   Homozygous Familial Hypercholesterolemic
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

The Impact of Medicaid Health Homes on Patients With Diabetes

Condition:   Type 2 Diabetes Mellitus
Intervention:  
Sponsors:   Icahn School of Medicine at Mount Sinai;   Patient-Centered Outcomes Research Institute;   New York City Clinical Data Research Network;   Weill Medical College of Cornell University;   The New York Academy of Medicine
Recruiting

Identification of Genes Expressed in Atherosclerotic Plaque

Condition:   Atherosclerosis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Evaluating the Use of Pitavastatin to Reduce the Risk of Cardiovascular Disease in HIV-Infected Adults

Conditions:   HIV Infections;   Cardiovascular Diseases
Interventions:   Drug: Pitavastatin;   Drug: Placebo
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   National Heart, Lung, and Blood Institute (NHLBI);   Kowa Pharmaceuticals America, Inc.;   Gilead Sciences;   Massachusetts General Hospital (MGH);   NEAT ID
Active, not recruiting

RESOLUTE ONYX Post-Approval Study (Bifurcation Cohort)

Condition:   Coronary Artery Disease
Intervention:   Device: Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System
Sponsor:   Medtronic Vascular
Active, not recruiting

HYbrid CoronAry Revascularization in DiabeticS

Conditions:   Diabetes;   Heart Disease
Interventions:   Procedure: Treatment;   Procedure: Control
Sponsor:   Ottawa Heart Institute Research Corporation
Completed

Registry of Secondary Revascularization

Conditions:   Coronary Artery Disease Progression;   Coronary Artery Disease of Significant Bypass Graft;   Stent Stenosis;   Stent Restenosis;   Coronary Arteriosclerosis
Intervention:  
Sponsors:   Hospital San Carlos, Madrid;   Laboratorios Farmacéuticos Rovi, S.A.;   S&H MEDICAL SCIENCE SERVICE, S.L.
Active, not recruiting

Study of Major Cardiovascular Events in Patients With Nonvalvular Atrial Fibrillation Treated With Rivaroxaban

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

Comparative Effectiveness of Cardiovascular Outcomes in New Users of SGLT-2 Inhibitors

Condition:   Diabetes Mellitus Type 2
Intervention:  
Sponsor:   AstraZeneca
Completed

Bingo Drug-Coated Balloon in Real World

Conditions:   Coronary Stenosis;   Drug-coated Balloon;   De Novo Stenosis;   Coronary Artery Disease in Transplanted Heart Accelerated
Intervention:  
Sponsor:   Yinyi(Liaoning) Biotech Co., Ltd.
Recruiting

Phase III Study Comparing Two Methods of Cardioplegia in Aortic Valve Surgery Custodiol-N Versus Custodiol

Conditions:   Aortic Valve Disease;   Coronary Artery Disease (CAD)
Interventions:   Drug: Custodiol-N;   Drug: Custodiol
Sponsor:   Dr. F. Köhler Chemie GmbH
Completed

ABILITY Diabetes Global

Conditions:   Diabetes;   Coronary Artery Disease;   Acute Coronary Syndrome
Interventions:   Device: Abluminus DES+ Sirolimus Eluting Stent System (SES);   Device: XIENCE Everolimus Eluting Coronary Stent System (XIENCE family)
Sponsor:   Concept Medical Inc.
Not yet recruiting

Single Dose Tranexamic Acid in Reducing Blood Loss During Cytoreductive Surgery and HIPEC

Condition:   Cytoreductive Surgery
Interventions:   Drug: tranexamic Acid infusion;   Drug: saline infusion
Sponsor:   Assiut University
Recruiting

Effect of a Multi-component Education Program on Salt Reduction in Adults

Conditions:   Blood Pressure;   Hypertension
Interventions:   Behavioral: Salt reduction program;   Behavioral: Healthy lifestyle program
Sponsors:   Academia Cuf Descobertas;   CUF Academic and Research Medical Center;   José de Mello Saúde;   Pingo Doce;   NOVA Medical School
Completed

PsA T2T Statin Trial on Carotid and Coronary Atherosclerosis

Conditions:   Psoriatic Arthritis;   Atherosclerosis
Interventions:   Drug: Rosuvastatin;   Other: Treat-to-target strategy
Sponsor:   Chinese University of Hong Kong
Not yet recruiting

A Randomized Clinical Trial of Resuming Direct Oral Anticoagulant Therapy Following Major Hemorrhage

Conditions:   Hemorrhage;   Intracranial Hemorrhages;   CVA; Hemorrhagic;   Bleeding
Intervention:   Drug: Anticoagulants
Sponsor:   University of Texas at Austin
Not yet recruiting

Optimal Hemostasis Duration for Percutaneous Coronary Intervention Via Snuffbox Approach

Conditions:   Bleeding;   Artery Injury
Intervention:   Procedure: Percutaneous coronary intervention via snuffbox approach
Sponsors:   Chonnam National University Hospital;   Wakayama Medical University;   The Catholic University of Korea
Active, not recruiting

Evaluation of the Efficacy and Safety of Single Dose Tranexamic Acid in Reducing Blood Loss During Colorectal Cancer Surgery

Condition:   Colorectal Surgery
Interventions:   Drug: Tranexamic Acid Injection;   Drug: placebo injection
Sponsor:   Assiut University
Recruiting

AOP2014 vs. BAT in Patients With Polycythemia Vera Who Previously Participated in the PROUD-PV Study.

Condition:   Polycythemia Vera
Interventions:   Drug: Pegylated-Proline-interferon alpha-2b;   Drug: Best available therapy (BAT)
Sponsors:   AOP Orphan Pharmaceuticals AG;   PharmaEssentia (Co-Sponsor for USA)
Active, not recruiting

OPtimized Stenting Using Intravascular Ultrasound(IVUS) in Long lEsion: Rationale for Simplified criteriA

Conditions:   Coronary Heart Disease;   Diabetes;   Vascular Lesions;   Chronic Total Occlusion of Coronary Artery;   Restenosis
Intervention:   Device: TAXUS™ Element long stent
Sponsors:   Centre Chirurgical Marie Lannelongue;   Hôpital Cochin;   Centre Hospitalier de La Rochelle;   University Hospital, Limoges;   Hôpital de la Timone;   Centre Hospitalier Universitaire de Nice;   Centre Hospitalier de PAU;   Rangueil Hospital;   Versailles Hospital
Completed

Hamburg AoRtic Valve cOhoRt

Condition:   Aortic Valve Stenosis
Intervention:  
Sponsor:   Universitätsklinikum Hamburg-Eppendorf
Recruiting

Study to Learn More About the Benefits and Side-effects of Drugs Rivaroxaban and Apixaban Compared to the Drug Warfarin for Stroke Prevention in Patients With Rapid and Irregular Heartbeat Which is Not Due to a Heart-valve Fault (Non-valvular Atrial Fibrillation) in the UK Routine Clinical Practice

Condition:   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Apixaban (Eliquis);   Drug: Warfarin
Sponsors:   Bayer;   Janssen, LP
Active, not recruiting

Major Adverse Cardiac Events After Carotid Endarterectomy

Conditions:   Carotid Stenosis;   Carotid Endarterectomy;   Adverse Cardiac Events
Intervention:  
Sponsor:   Mahidol University
Completed

Safety, Efficacy, Longitudinal Costs and Patient-Centered Outcomes Using a TAAA Debranching Device

Condition:   Thoracoabdominal Aortic Aneurysm
Interventions:   Device: Visceral Manifold and Thoracic Bifurcation;   Device: Unitary Manifold;   Device: TAAA Debranching Stent Graft System
Sponsor:   Johns Hopkins University
Enrolling by invitation

A Study to Evaluate the Safety and Effectiveness of Rivaroxaban (Xarelto) for Prevention of Stroke and Systemic Embolism in Indian Patients With Non-valvular Atrial Fibrillation (NVAF)

Condition:   Non-valvular Atrial Fibrillation (NVAF)
Intervention:   Drug: Rivaroxaban (Xarelto,Bay 59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting

Safety and Effectiveness of the Orsiro Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions

Conditions:   Coronary Artery Disease;   Atherosclerosis, Coronary;   Myocardial Ischemia;   Ischemic Heart Disease;   Acute Coronary Syndrome;   Angina Pectoris
Intervention:   Device: Orsiro DES
Sponsor:   Biotronik, Inc.
Not yet recruiting

Study to Gather Information to What Extent Patients Follow the Treatment Regimen of Low-dose Aspirin for Primary and Secondary Prevention of Diseases of the Heart and Blood Vessels

Conditions:   Myocardial Infarction;   Stroke (Including Ischaemic Stroke and Transient Ischaemic Attack);   Unstable Angina;   Angina;   Ischaemic Heart Disease
Intervention:   Drug: Acetylsalicylic Acid (Aspirin, BAYE4465)
Sponsor:   Bayer
Active, not recruiting

Safety and Effectiveness of Agent Paclitaxel-Coated PTCA Balloon Catheter. (AGENT Japan SV)

Condition:   Coronary Artery Disease
Interventions:   Device: Device: Paclitaxel-Coated PTCA Balloon Catheter;   Device: SeQuent Please Drug Eluting Balloon Catheter with Paclitaxel
Sponsor:   Boston Scientific Corporation
Recruiting

Naloxegol US PMR CV Safety.

Condition:   Opioid Induced Constipation
Interventions:   Drug: naloxegol;   Drug: non-PAMORA
Sponsor:   AstraZeneca
Recruiting

Replication of the PLATO Antiplatelet Trial in Healthcare Claims Data

Condition:   Antiplatelet
Interventions:   Drug: Ticagrelor 90mg;   Drug: Clopidogrel 75mg
Sponsor:   Brigham and Women's Hospital
Active, not recruiting

Replication of the TRITON-TIMI Antiplatelet Trial in Healthcare Claims Data

Condition:   Antiplatelet
Interventions:   Drug: Prasugrel 10mg;   Drug: Clopidogrel 75mg
Sponsor:   Brigham and Women's Hospital
Active, not recruiting

An "All-Comers" Study of the AgentTM MONORAILTM Paclitaxel-Coated PTCA Balloon Catheter Used in Real-World Clinical Practice in Chinese Patients

Condition:   Chinese Patients Treated With Agent DCB
Intervention:   Device: AgentTM MONORAILTM Paclitaxel-Coated PTCA Balloon Catheter
Sponsor:   Boston Scientific Corporation
Recruiting

Moderato System: A Double-Blind Randomized Trial Ver 1.1

Conditions:   Hypertension Resistant to Conventional Therapy;   Bradycardia;   Atrioventricular Block
Interventions:   Device: PHC ON;   Device: PHC OFF
Sponsors:   BackBeat Medical Inc;   Massachusetts General Hospital;   MLM Medical Labs GmbH;   nabios GmbH
Active, not recruiting

Evaluating New Radiation Techniques for Cardiovascular Imaging

Condition:   Coronary Disease
Intervention:   Device: The Toshiba Aquilion ONE CT system
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Suspended

Zenith® TXD Post-market Surveillance in Japan

Condition:   Aortic Dissection
Intervention:   Device: Zenith® TXD
Sponsor:   Cook Group Incorporated
Active, not recruiting

IU Health Krannert Personalized Medicine Study

Condition:   Coronary Artery Disease
Intervention:   Genetic: CYP2C19 genotyping
Sponsor:   Indiana University
Terminated

Comparative Effectiveness of Empagliflozin in the US

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Empagliflozin;   Drug: DPP-4 inhibitor
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting

Aclidinium Bromide Post-Authorisation Safety Study to Evaluate the Risk of Cardiovascular Endpoints

Condition:   Pulmonary Disease, Chronic Obstructive
Interventions:   Drug: Aclidinium bromide;   Drug: Other COPD medication
Sponsors:   AstraZeneca;   RTI Health Solutions
Recruiting

An Observational Registry to Evaluate the Incidence of and Risk Factors for Vascular Occlusive Events Associated With ICLUSIG®

Condition:   Myeloid Leukemia, Chronic-Phase, Accelerated-Phase, Blast-Phase, Ph+ALL
Intervention:  
Sponsors:   Ariad Pharmaceuticals;   United BioSource Corporation
Recruiting

A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men

Conditions:   Hypogonadism;   Cardiovascular Diseases
Interventions:   Drug: Testosterone;   Drug: Placebo
Sponsors:   AbbVie;   Acerus Pharmaceuticals Corporation;   Allergan Sales, LLC;   Endo Pharmaceuticals;   Upsher-Smith Laboratories
Recruiting

Outcomes After Hypotensive Neuraxial Anesthesia in Total Hip Arthroplasty

Conditions:   Total Hip Arthroplasty;   Primary Total Hip Arthroplasty;   Hypotension;   Database
Intervention:   Other: Chart Review
Sponsor:   Hospital for Special Surgery, New York
Completed

Endurant CHevAr New Indication Trial: ENCHANT

Condition:   AAA - Abdominal Aortic Aneurysm
Intervention:   Device: Endurant Chimney Graft Technique
Sponsor:   Medtronic Endovascular
Recruiting

Avr Thrombosis OutcoMe Study

Condition:   Aortic Stenosis
Intervention:   Diagnostic Test: Blood test
Sponsors:   East and North Hertfordshire NHS Trust;   Royal Brompton & Harefield NHS Foundation Trust
Not yet recruiting

Geriatric Fracture Centers - Evaluation of a Geriatric Co-management Program

Condition:   Hip Fractures
Intervention:  
Sponsor:   AO Clinical Investigation and Documentation
Active, not recruiting

ACURATE TF™ Transfemoral Aortic Bioprosthesis for Implantation in Patients With Severe Aortic Stenosis (2011-03)

Condition:   Aortic Stenosis Symptomatic
Intervention:   Device: ACURATE TF™ Aortic Valve System
Sponsor:   Symetis SA
Active, not recruiting

A Study Based on Data From German Registries That Looks at Characteristics of People Who Take the Medicine Empagliflozin for Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Intervention:   Drug: Empagliflozin
Sponsor:   Boehringer Ingelheim
Completed

Chinese Chronic Renal Insufficiency Study: Based on Smartphone Platform

Condition:   Chronic Kidney Diseases
Intervention:  
Sponsors:   Limeng Chen;   First Hospital of China Medical University;   People's Hospital of Xinjiang Autonomous Region;   Fujian Provincial Hospital;   Shandong Provincial Qianfoshan Hospital;   First Affiliated Hospital Xi'an Jiaotong University;   Seventh Affiliated Hospital of Sun Yat-sen University;   People's Hospital of Ningxia Hui Autonomous Region
Not yet recruiting

Pre-market Study of the DREAMS 2G Drug Eluting Absorbable Metal Scaffold (BIOSOLVE-III)

Conditions:   Coronary Artery Disease;   Coronary Artery Stenosis
Intervention:   Device: Percutaneous Coronary Intervention
Sponsor:   Biotronik AG
Completed

Active Detection of the Extension of Atherothrombosis in High Risk Coronary Patients

Condition:   Coronary Artery Disease
Interventions:   Other: Arterial doppler for screening asymptomatic and significant extracoronary arterial stenoses in all arterial beds;   Other: Conservative arm
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Institut de l'Atherothrombose
Completed

MBCT Delivered Via Group Videoconferencing for ACS Syndrome Patients With Depressive Symptoms

Conditions:   Acute Coronary Syndrome;   Depression;   Myocardial Infarction;   Unstable Angina;   STEMI;   NSTEMI - Non-ST Segment Elevation MI
Intervention:   Other: MBCT intervention for ACS patients
Sponsor:   Massachusetts General Hospital
Not yet recruiting

Zenith® Dissection Clinical Trial

Condition:   Aortic Dissection
Intervention:   Device: Endovascular Treatment (Zenith)
Sponsor:   Cook Research Incorporated
Active, not recruiting

IDE Trial for Boston Scientific's Cryoballoon in the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Intervention:   Device: POLARx™ Cardiac Cryoablation System
Sponsor:   Boston Scientific Corporation
Not yet recruiting

Cephea Transseptal Mitral Valve System FIH

Condition:   Mitral Regurgitation
Intervention:   Device: Transcatheter Mitral Valve Replacement via Transseptal Access
Sponsor:   Cephea Valve Technologies
Completed

Correlation Between MLR and Risk of Death and Cardiovascular Events in PD Patients.

Conditions:   Peritoneal Dialysis;   Inflammation
Intervention:   Other: monocyte / lymphocyte ratio
Sponsor:   Zhujiang Hospital
Not yet recruiting

Effectiveness and Safety of Mitral Valve Repair With the NeoChord DS1000 Artificial Chordae Delivery System Versus Conventional Surgery in Patients With Severe Primary Mitral Regurgitation Due to Isolated Leaflet Prolapse

Condition:   Cardiovascular Diseases
Interventions:   Device: NeoChord beating heart mitral valve implantation;   Procedure: Control
Sponsor:   Hospices Civils de Lyon
Withdrawn

Re-hospitalized Patients With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   Cardiovascular Academy Society, Turkey
Completed

Canadian Alliance for Healthy Hearts and Minds

Condition:   Cardiovascular Diseases
Intervention:   Other: MRI
Sponsor:   Montreal Heart Institute
Completed

Telemetry for Chest Pain of Low Risk for Acute Coronary Syndrome Pts

Conditions:   Chest Pain;   Telemetry;   Acute Coronary Syndrome;   Health Care Resource Utilization
Interventions:   Other: No Telemetry Monitoring;   Device: Telemetry Monitoring
Sponsors:   Carilion Clinic;   Johns Hopkins University;   University of Maryland, College Park;   Virginia Commonwealth University;   Medstar Health Research Institute;   Virginia Tech Carilion School of Medicine and Research Institute
Withdrawn

Cardiomyocyte Injury Following Acute Ischemic Stroke

Conditions:   Stroke, Ischemic;   Cardiac Complication
Intervention:  
Sponsor:   Charite University, Berlin, Germany
Recruiting

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Conditions:   Acute Coronary Syndrome;   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Active, not recruiting

Intracoronary Infusion of Mononuclear Cells Autologous Bone Marrow in Patients With Chronic Coronary Occlusion and Ventricular Dysfunction, Previously Revascularized.

Condition:   Coronary Atherosclerosis and Other Heart Disease
Interventions:   Other: Mononuclear cells from autologous bone marrow;   Drug: Conventional medical treatment
Sponsors:   Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud;   Iniciativa Andaluza en Terapias Avanzadas
Recruiting

Diagnostic Accuracy of On-line Quantitative Flow Ratio (QFR). FAVOR II Europe-Japan

Condition:   Coronary Artery Disease
Intervention:   Other: QFR (observational)
Sponsor:   Aarhus University Hospital Skejby
Completed

GLORIA-AF Registry Program - Second and Third Phases

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Cardiovascular Events in Chronic Obstructive Pulmonary Disease Patients Initiating Olodaterol or Other Long-acting beta2 Agonists

Condition:   Pulmonary Disease, Chronic Obstructive
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Surgical Implantation of TRAnscatheter vaLve in Native Mitral Annular Calcification (SITRAL) Study

Condition:   Mitral Annular Calcification
Intervention:   Device: Mitral Valve Replacement with Sapien3
Sponsors:   Baylor Research Institute;   Edwards Lifesciences
Recruiting

HighLife™ Transcatheter Mitral Valve Replacement System Study

Conditions:   Mitral Valve Regurgitation;   Mitral Valve Insufficiency
Intervention:   Device: Transcatheter Mitral Valve Replacement
Sponsors:   HighLife SAS;   MedPass International
Active, not recruiting

Sleep Apnea and Atrial Fibrillation Recurrence

Conditions:   Sleep Apnea Syndrome;   Atrial Fibrillation
Intervention:   Other: Intervention group
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Germany)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsors:   Bayer;   Janssen Research & Development, LLC
Completed

Study to Develop a Prediction Model to Understand the Effect of Low-dose Aspirin on Cancer That Develops in the Colon and/or the Rectum, Diseases That Affects the Heart or Blood Vessels and Safety Outcomes in European Countries. The Study is Also Called PEACOS Model EU

Conditions:   Colorectal Cancer;   Cardiovascular Disease;   Bleeding
Intervention:   Drug: Acetylsalicylic Acid (Aspirin, BAYE4465)
Sponsor:   Bayer
Active, not recruiting

Efficacy and Safety of Apixaban in Reducing Restenosis and Limb Loss in PAD Patients.

Condition:   Critical Limb Ischemia
Interventions:   Drug: Apixaban;   Drug: ASA;   Drug: Clopidogrel 75mg
Sponsors:   Science Valley Research Institute;   Wyeth is now a wholly owned subsidiary of Pfizer
Recruiting

Effect of Pre-op NRT on Peri-operative Complications and Long-term Abstinence: A Pilot Trial in Patients Undergoing CABG Surgery

Condition:   Smoking Cessation
Intervention:   Drug: Nicoderm Patch
Sponsor:   Ottawa Heart Institute Research Corporation
Recruiting

Bariatric Surgery for the Reduction of cArdioVascular Events Feasibility Trial

Conditions:   Obesity, Morbid;   Cardiovascular Diseases
Intervention:   Procedure: Bariatric surgery
Sponsors:   Hamilton Health Sciences Corporation;   Population Health Research Institute;   St. Joseph's Healthcare Hamilton
Not yet recruiting

Antiplatelet Therapy in Acute Mild-Moderate Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: clopidogrel;   Drug: Aspirin
Sponsor:   General Hospital of Shenyang Military Region
Recruiting

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

TReAtmeNt of Small Coronary Vessels: MagicTouch Sirolimus Coated Balloon

Condition:   Coronary Artery Disease
Interventions:   Device: sirolimus drug coated balloon (SCB);   Device: paclitaxel releasing coronary balloon catheter
Sponsor:   Concept Medicals BV
Not yet recruiting

Cangrelor in Comatose Survivors of OHCA Undergoing Primary PCI

Conditions:   Out-Of-Hospital Cardiac Arrest;   Acute Coronary Syndrome
Intervention:   Drug: Cangrelor 50 MG
Sponsors:   University Medical Centre Ljubljana;   Chiesi Slovenija, d.o.o.
Recruiting

TherApy in stabLe Coronary Artery dIsease Patients According to Clinical GuideliNes (ALIGN)

Condition:   Stable Ischemic Heart Disease
Intervention:   Behavioral: Patients with documented IHD
Sponsor:   National Research Center for Preventive Medicine
Active, not recruiting

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Warfarin;   Drug: Antiplatelet drugs
Sponsors:   Bayer;   Janssen Research & Development, LLC
Completed

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxoban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Completed

Trends in the Epidemiology and Treatment of Atopic Dermatitis in the United Kingdom (UK)

Conditions:   Atopic Dermatitis Eczema;   Atopic Dermatitis;   Eczema
Intervention:   Other: No intervention
Sponsors:   Momentum Data;   Pfizer;   Royal College of General Practitioners Research and Surveillance Centre
Active, not recruiting

Finding Atrial Fibrillation in Stroke - Evaluation of Enhanced and Prolonged Holter Monitoring

Condition:   Stroke
Interventions:   Other: prolonged ECG monitoring;   Other: standard care
Sponsor:   Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH
Completed

Strategies for the Management of Atrial Fibrillation in patiEnts Receiving HemoDialysis

Conditions:   Atrial Fibrillation;   End Stage Renal Failure on Dialysis
Interventions:   Drug: Warfarin;   Drug: Apixaban;   Other: No oral anticoagulation
Sponsors:   St. Michael's Hospital, Toronto;   Canadian Institutes of Health Research (CIHR)
Recruiting

Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass

Conditions:   Cardiac Disease;   Bleeding Postoperative
Interventions:   Other: Fresh Autologous whole Blood;   Other: Standard of Care Expectant management of bleeding
Sponsor:   University of Colorado, Denver
Not yet recruiting

Anemia Studies in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat in Non-Dialysis Subjects Evaluating Hemoglobin (Hgb) and Quality of Life (ASCEND-NHQ)

Condition:   Anaemia
Interventions:   Drug: Daprodustat (GSK1278863);   Drug: Placebo;   Drug: Iron therapy
Sponsor:   GlaxoSmithKline
Recruiting

Cardiovascular Risk and Chronic Obstructive Pulmonary Disease

Condition:   Chronic Obstructive Pulmonary Disease
Intervention:  
Sponsor:   University Hospital, Grenoble
Recruiting

A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel

Conditions:   Acute Ischemic Stroke;   Transient Ischemic Attack (TIA)
Interventions:   Drug: BMS-986177;   Other: Placebo;   Drug: Clopidogrel;   Drug: Aspirin
Sponsors:   Bristol-Myers Squibb;   Janssen, LP
Recruiting

A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

First in Man Study of the DREAMS 2nd Generation Drug Eluting Absorbable Metal Scaffold (BIOSOLVE-II)

Conditions:   Coronary Artery Disease;   Coronary Artery Stenosis
Intervention:   Device: Percutaneous Coronary Intervention (DREAMS) stenting
Sponsor:   Biotronik AG
Active, not recruiting

Montelukast for Patients With Obstructive Sleep Apnea Syndrome

Condition:   Sleep Apnea, Obstructive
Interventions:   Drug: Montelukast 10mg;   Drug: Placebo
Sponsors:   University Hospital, Grenoble;   Act For Chronic Diseases;   Direction Générale de l'Offre de Soins
Recruiting

This Study Looks at the Effects of Idarucizumab in Patients Who Take Dabigatran and Need Emergency Surgery or Are Bleeding

Condition:   Atrial Fibrillation
Intervention:   Drug: Idarucizumab
Sponsor:   Boehringer Ingelheim
Recruiting

Preventing pAIn With NMDA Antagonists - Steroids in Thoracoscopic lObectomy Procedures (PAIN-STOP) Pilot Trial

Condition:   Pain, Postoperative
Interventions:   Drug: NMDA active;   Drug: Steroid active;   Drug: NMDA placebo;   Drug: Steroid placebo
Sponsor:   Population Health Research Institute
Terminated

OPTIMAl Endovascular Exclusion of Consecutive Patient High-risk Carotid Plaque Using the MicroNet Covered Stent

Condition:   Carotid Artery Diseases
Intervention:   Diagnostic Test: Intravascular Utrasound (IVUS) of Carotid Artery after implantation of CGuard stent
Sponsors:   John Paul II Hospital, Krakow;   InspireMD
Not yet recruiting

REVERSE-AKI Randomized Controlled Pilot Trial

Conditions:   Acute Kidney Injury;   Critical Illness
Intervention:   Other: Restrictive fluid management
Sponsors:   Helsinki University Central Hospital;   Austin Hospital, Melbourne Australia;   Guy's and St Thomas' NHS Foundation Trust;   University Hospital, Ghent;   Medical University Innsbruck;   Lausanne University Hospital
Recruiting

OCT vs IVUS vs QCA to Guide Moderate-to-severe Calcified Lesion Stent Implantation

Conditions:   Optical Coherence Tomography;   Intravascular Ultrasound;   Angiography
Interventions:   Device: OCT guidance;   Device: IVUS guidance;   Device: QCA
Sponsor:   Shanghai MicroPort Medical (Group) Co., Ltd.
Recruiting

COlchicine in Cardiac Surgery

Conditions:   Colchicine Adverse Reaction;   Atrial Fibrillation New Onset
Interventions:   Drug: Colchicine;   Drug: Placebo
Sponsor:   Bakulev Scientific Center of Cardiovascular Surgery
Recruiting

Community Health Assessment Program in the Philippines (CHAP-P)

Conditions:   Diabetes Mellitus, Type 2;   Hypertension
Intervention:   Other: CHAP-P Sessions
Sponsors:   McMaster University;   Ateneo de Zamboanga University;   Université de Montréal;   Global Alliance for Chronic Diseases (GACD);   Canadian Institutes of Health Research (CIHR);   International Development Research Centre, Canada
Active, not recruiting

Risk Communication About Post-operative Delirium (POD) and Post-operative Cognitive Dysfunction (POCD)

Conditions:   Post-operative Delirium;   Post-operative Cognitive Dysfunction
Intervention:  
Sponsor:   Charite University, Berlin, Germany
Not yet recruiting

Aspirin Use for Gastric Cancer Prevention in the Early Gastric Cancer Patients

Conditions:   Aspirin;   Gastric Cancer
Interventions:   Drug: Aspirin 100mg;   Drug: Placebo oral tablet
Sponsors:   National Cancer Center, Korea;   Incheon St.Mary's Hospital/The Catholic University;   Kosin University Gospel Hospital;   Pusan National University Hospital;   SMG-SNU Boramae Medical Center;   Chonnam National University Hospital;   Chung-Ang University Hosptial, Chung-Ang University College of Medicine;   Chilgok Kyungpook National University;   Hallym University Medical Center
Not yet recruiting

Effects of Shift Work on Nurse Staff Health

Conditions:   Shift Work Type Circadian Rhythm Sleep Disorder;   Chronobiology Disorders;   Mood Swing;   Physical Activity;   Cardiovascular Diseases
Intervention:   Other: Shifts working hours with different schedules
Sponsor:   Istituto Ortopedico Galeazzi
Completed

Nitric Oxide in Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO)

Conditions:   Extracorporeal Membrane Oxygenation;   Nitric Oxide;   Shock, Cardiogenic
Intervention:   Drug: Inhaled nitric oxide
Sponsors:   Filio Billia;   Peter Munk Cardiac Center;   Heart and Stroke Foundation of Canada;   University of Toronto
Recruiting

Desflurane,Brain Natriuretic Peptide and Cardiac Surgery

Conditions:   Brain Natriuretic Peptide;   Coronary Artery Bypass Graft Surgery;   Cardiac Surgery;   Cardiopulmonary Bypass;   Desflurane;   Outcome
Intervention:   Drug: Desflurane Inhalational agent
Sponsors:   Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital;   Trakya University Faculty of Medicine Hospital
Completed

PPCM Observational Study (Peripartum Cardiomyopathy)

Conditions:   Peripartum Cardiomyopathy;   Cardiogenic Shock
Intervention:   Device: Clinical placement of a temporary IMPELLA® mechanical circulatory support device.
Sponsors:   Medical College of Wisconsin;   Abiomed Inc.;   Mayo Clinic;   University of Pennsylvania
Not yet recruiting

The Impact of Medicare Bundled Payments

Condition:   Arthroplasty, Replacement
Intervention:   Other: Bundled payments for knee and hip replacement
Sponsors:   Amy Finkelstein;   Harvard University;   University of Chicago;   Dartmouth College
Enrolling by invitation

Postoperative Replacement of Intraoperative Iron Losses

Condition:   Blood Loss Anemia
Interventions:   Drug: Ferric carboxymaltose;   Drug: Crystalloid
Sponsor:   Kepler University Hospital
Recruiting

Belimumab With Rituximab for Primary Membranous Nephropathy

Conditions:   Membranous Nephropathy;   MN
Interventions:   Drug: Belimumab;   Drug: Placebo for Belimumab;   Drug: Rituximab
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Immune Tolerance Network (ITN);   GlaxoSmithKline
Recruiting

ZEnith AlPHa for AneurYsm Repair

Condition:   Aneurysm
Intervention:   Procedure: Zenith Alpha Abdominal stentgraft
Sponsors:   Philippe Cuypers;   Syntactx
Active, not recruiting

A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease

Conditions:   Coronary Disease;   Coronary Stenosis
Interventions:   Procedure: FFR guided PCI;   Procedure: CABG
Sponsors:   Stanford University;   VZW Cardiovascular Research Center Aalst;   Catharina Ziekenhuis Eindhoven;   Golden Jubilee National Hospital;   University of California, Irvine;   Medtronic;   Abbott Medical Devices;   Genae;   King's College Hospital, London;   Houston Methodist DeBakey Heart and Vascular Center, Houston
Active, not recruiting

Pegylated Interferon Alfa-2b Versus Interferon Alfa Therapy in the Treatment of Childhood Essential Thrombocythemia

Condition:   Essential Thrombocytopenia
Interventions:   Drug: Recombinant Interferon Alpha;   Drug: Pegylated interferon alfa-2b
Sponsor:   Institute of Hematology & Blood Diseases Hospital
Recruiting

Robotic-assisted Esophagectomy vs. Video-Assisted Thoracoscopic Esophagectomy(REVATE) Trial

Condition:   Esophageal Squamous Cell Carcinoma
Intervention:   Device: Robot esophagectomy (RE)
Sponsor:   Chang Gung Memorial Hospital
Recruiting

Parenteral Antibiotics Compared to Combination of Oral and Parenteral Antibiotics in Colorectal Surgery Prophylaxis

Condition:   Surgical Wound Infection
Interventions:   Drug: Extra dosage - cefuroxime (750mg) I.V;   Procedure: Colorectal Surgery;   Drug: Ciprofloxacin 750 mg oral;   Drug: Metronidazole 250 mg oral;   Drug: Cefuroxime 1.5 g Intravenous;   Drug: Metronidazole 1 g Intravenous
Sponsor:   Hospital Universitari Vall d'Hebron Research Institute
Completed

A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Non-Hospitalized Participants With Influenza A Infection Who Are at Risk of Developing Complications

Condition:   Influenza A
Interventions:   Drug: Pimodivir 600 mg;   Drug: Placebo;   Other: SOC Treatment
Sponsor:   Janssen Research & Development, LLC
Recruiting

A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Hospitalized Participants With Influenza A Infection

Condition:   Influenza A
Interventions:   Drug: Pimodivir 600 mg;   Drug: Placebo;   Other: SOC Treatment
Sponsor:   Janssen Research & Development, LLC
Recruiting

Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

Conditions:   Obstructive Sleep Apnea of Adult;   Preeclampsia;   Obstetrical Complications
Interventions:   Device: Continuous Positive Airway Pressure;   Other: Sleep Hygiene Control
Sponsors:   The George Washington University Biostatistics Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Prevalence of Subclinical Atrial Fibrillation in Heart Failure Patients and Its Relationship With Hospital Readmission

Conditions:   Heart Failure;   Atrial Fibrillation
Intervention:   Device: ECG Patch, pocket ECG monitor
Sponsors:   Population Health Research Institute;   Heart and Stroke Foundation of Canada;   Canadian Cardiovascular Society
Recruiting

CCC Project - Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:  
Sponsors:   Beijing Institute of Heart, Lung and Blood Vessel Diseases;   American Heart Association;   Chinese Society of Cardiology
Recruiting

The Left Ventricular Assist Device(LVAD) Off or On Pump Implantation Study

Conditions:   Heart Failure;   LVAD
Interventions:   Device: Off-Pump;   Device: On-Pump
Sponsor:   The University of Texas Health Science Center, Houston
Not yet recruiting