Heart Attack

Clinical Trial Finder

Many patients with heart disease are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Short-Term Application of Tocilizumab Following Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Drug: Tocilizumab;   Drug: Placebo
Sponsor:   Keesler Air Force Base Medical Center
Recruiting - verified April 2015

Study Apixaban to Vitamin K Antagonist for the Prevention of Stroke or Systemic Embolism and Bleeding in Patients With Non-valvular Atrial Fibrillation and Acute Coronary Syndrome/Percutaneous Coronary Intervention

Condition:   Acute Coronary Syndromes
Interventions:   Drug: Apixaban;   Drug: vitamin K antagonist;   Drug: Acetylsalicylic acid;   Other: Acetylsalicylic acid placebo
Sponsors:   Bristol-Myers Squibb;   Pfizer;   Duke Clinical Research Institute
Not yet recruiting - verified April 2015

Medtronic Resolute Onyx Core (2.25 mm - 4.0 mm) Clinical Study

Condition:   Coronary Artery Disease
Intervention:   Device: Resolute Onyx Stent - 2.25 mm - 4.0 mm
Sponsor:   Medtronic Vascular
Not yet recruiting - verified April 2015

Prospective, Interventional Study Evaluating the Feasibility and Safety of the Esophageal Cooling Device

Condition:   Traumatic Brain Injury
Intervention:   Device: Esophageal Cooling Device (ECD), manufactured by Advanced Cooling Therapy, Inc.
Sponsors:   Advanced Cooling Therapy, LLC;   Dnipropetrovsk State Medical Academy
Not yet recruiting - verified April 2015

Therapeutic Use of Ultrasound in Acute Coronary Artery Disease

Condition:   Acute Myocardial Infarction
Interventions:   Procedure: Therapeutic ultrasound with 20 usec;   Procedure: Repeated diagnostic high mechanical index
Sponsors:   University of Sao Paulo General Hospital;   University of Nebraska
Recruiting - verified April 2015

Researches of Retinal Artery Lesions and Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   Capital Medical University
Active, not recruiting - verified April 2015

Identification of the Blood Microbiota in Patient Suffering From Myocardial Infraction

Conditions:   Coronary Disease;   Myocardial Infarction
Intervention:  
Sponsor:   University Hospital, Toulouse
Recruiting - verified April 2015

Test Efficacy With Bioresorbable Polymer Coating Versus Bioresorbable Polymer Backbone (ISAR-RESORB)

Condition:   Coronary Stenosis
Interventions:   Device: SYNERGY EES;   Device: ABSORB [BVS]
Sponsor:   Deutsches Herzzentrum Muenchen
Not yet recruiting - verified April 2015

Medtronic Resolute Onyx 2.0 mm Clinical Study

Condition:   Coronary Artery Disease
Intervention:   Device: Resolute Onyx Stent - 2.0 mm
Sponsor:   Medtronic Vascular
Not yet recruiting - verified April 2015

Brilinta Taiwan Post Approval Safety Study

Condition:   Non ST-elevation Myocardial Infarction
Intervention:   Drug: Ticagrelor 180mg loading dose taken orally, followed by 90mg twice daily (bd)
Sponsor:   AstraZeneca
Not yet recruiting - verified April 2015

Safety and Efficacy of Low-Dose Ticagrelor in Chinese Patients With NSTE-ACS

Condition:   Non ST Segment Elevation Acute Coronary Syndrome
Interventions:   Drug: low-dose ticagrelor;   Drug: conventional-dose ticagrelor;   Drug: Clopidogrel
Sponsor:   First Affiliated Hospital of Harbin Medical University
Recruiting - verified December 2014

Open Label Study of Single Agent Oral RG7388 in Patients With Polycythemia Vera and Essential Thrombocythemia

Conditions:   Polycythemia Vera;   Essential Thrombocythemia
Interventions:   Drug: RG7388;   Drug: Pegasys
Sponsors:   John Mascarenhas;   Genentech, Inc.;   Roche Pharma AG
Recruiting - verified April 2015

Immediate Versus Delayed Invasive Intervention for Non-STEMI Patients

Condition:   Myocardial Infarction
Interventions:   Procedure: Immediate invasive intervention;   Procedure: Delayed invasive intervention;   Device: Coronary artery stenting
Sponsor:   Clinical Centre of Serbia
Active, not recruiting - verified April 2015

CardiOvascular Risk and idEntificAtion of Potential High-risk Population in Acute Myocardial Infarction

Conditions:   Long-term Major Cardiovascular Events;   Myocardial Infarction;   Percutaneous Coronary Intervention
Interventions:   Device: Percutaneous coronary intervention;   Device: Percutaneous coronary intervention
Sponsors:   Kiyuk Chang;   The Catholic University of Korea;   Chonnam National University
Completed - verified April 2015

SONOlysis in Prevention of Brain InfaRctions During Internal Carotid Endarterectomy

Condition:   Internal Carotid Artery Stenosis
Intervention:   Device: sonolysis
Sponsors:   University Hospital Ostrava;   Military University Hospital, Prague;   Vitkovice Hospital, Ostrava;   Masaryk Hospital, Usti nad Labem;   České Budějovice Hospital;   University Hospital Hradec Kralove;   University Hospital Plzen, Plzen;   County Hospital Liberec, Liberec
Not yet recruiting - verified April 2015

The Development and Evaluation of a Brief CFT Intervention for Trauma

Conditions:   Trauma;   PTSD
Intervention:   Other: Compassion Focused Therapy (self-practice)
Sponsors:   University of Lincoln;   University of Nottingham
Recruiting - verified April 2015

Evaluating the Use of Pitavastatin to Reduce the Risk of Cardiovascular Disease in HIV-Infected Adults

Conditions:   HIV Infections;   Cardiovascular Diseases
Interventions:   Drug: Pitavastatin;   Drug: Placebo
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   National Heart, Lung, and Blood Institute (NHLBI);   Kowa Pharmaceuticals America, Inc.
Recruiting - verified April 2015

Weight Loss Referral for Healthier Survivorship in Obese Stage I-II Endometrial Cancer Survivors or Atypical Hyperplasia

Conditions:   Complex Endometrial Hyperplasia With Atypia;   Stage IA Uterine Corpus Cancer;   Stage IB Uterine Corpus Cancer;   Stage II Uterine Corpus Cancer
Interventions:   Behavioral: Weight Loss Specialist;   Other: Quality-of-Life Assessment;   Other: Medical Chart Review
Sponsors:   Case Comprehensive Cancer Center;   National Cancer Institute (NCI)
Recruiting - verified April 2015

Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

Conditions:   Myelodysplastic Syndrome;   Hodgkin's Lymphoma;   Non-Hodgkin's Lymphoma;   Acute Leukemia;   Multiple Myeloma
Interventions:   Biological: Rituximab;   Drug: Conditioning Chemotherapy;   Drug: TMS;   Drug: FLAG;   Drug: EPOCH-F;   Procedure: Hematopoietic Stem Cell Transplant;   Drug: Palifermin
Sponsor:   National Cancer Institute (NCI)
Not yet recruiting - verified January 2015

Jakarta Acute Coronary Syndrome Registry

Condition:   Acute Coronary Syndrome
Intervention:   Other: JAC Registry
Sponsor:   National Cardiovascular Center Harapan Kita Hospital Indonesia
Recruiting - verified April 2015

A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Acetylsalicylic acid;   Drug: Rivaroxaban;   Drug: Clopidogrel;   Drug: Ticagrelor
Sponsors:   Janssen Research & Development, LLC;   Bayer;   Duke Clinical Research Institute;   Harvard Medical School
Not yet recruiting - verified April 2015

RuSsian RegisTry of Acute CoronaRy SyndromE TreAtMent and Approach in Dual Antiplatelet Therapy

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   AstraZeneca
Not yet recruiting - verified April 2015

Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System

Condition:   Mitral Valve Regurgitation
Intervention:   Device: Mitral valve replacement
Sponsor:   Neovasc Inc.
Recruiting - verified March 2015

Pilot Study to Examine the Use of Rivaroxaban After Angioplasty for Critical Limb Ischemia

Condition:   Critical Limb Ischemia
Interventions:   Drug: rivaroxaban plus aspirin;   Drug: clopidogrel plus aspirin
Sponsors:   Ottawa Hospital Research Institute;   The Ottawa Hospital
Recruiting - verified April 2015

Brain fMRT In Takotsubo Cardiomyopathy

Condition:   Takotsubo Cardiomyopathy
Intervention:  
Sponsor:   Wolfgang Dichtl
Recruiting - verified April 2015

Influence of Morphine on Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients With Acute Myocardial Infarction

Conditions:   ST-segment Elevation Myocardial Infarction;   Non-ST-segment Elevation Myocardial Infarction;   VA Drug Interactions [VA Drug Interaction]
Interventions:   Drug: Morphine;   Drug: Placebo;   Drug: Ticagrelor
Sponsor:   Collegium Medicum w Bydgoszczy
Recruiting - verified April 2015

Canadian Alliance for Healthy Hearts and Minds

Condition:   Cardiovascular Diseases
Intervention:   Other: MRI
Sponsor:   Montreal Heart Institute
Recruiting - verified April 2015

Using Ripple Mapping to Guide Substrate Ablation of Scar Related Ventricular Tachycardia.

Conditions:   Monomorphic Ventricular Tachycardia;   Myocardial Infarction;   Dilated Cardiomyopathy
Interventions:   Device: Ripple Mapping guided VT ablation;   Device: Conventional VT ablation
Sponsor:   Imperial College London
Recruiting - verified July 2014

AOP2014 in Patients With Polycythemia Vera Who Previously Participated in the PROUD-PV Study.

Condition:   Polycythemia Vera
Intervention:   Drug: Pegylated-Proline-interferon alpha-2b
Sponsors:   AOP Orphan Pharmaceuticals AG;   PharmaEssentia (Co-Sponsor for USA)
Recruiting - verified April 2015

Intravascular Ultrasound Guided Drug Eluting Stent Implantation in "All-comers" Coronary Lesions

Condition:   Coronary Artery Disease
Interventions:   Procedure: Angiography;   Procedure: IVUS;   Procedure: DES implantation
Sponsor:   The First Hospital of Nanjing Medical University
Recruiting - verified April 2015

Influence of Renal Function on the Circadian Variation of Cardiac Troponin

Condition:   Chronic Kidney Diseases
Intervention:  
Sponsor:   Maastricht University Medical Center
Recruiting - verified April 2015

Cardiovascular Patient Outcomes and Research Team Primary PCI Registry

Condition:   ST Elevation Myocardial Infarction
Intervention:  
Sponsor:   Johns Hopkins University
Recruiting - verified April 2015

Active Surveillance Research Program for the Assessment of the Safety and the Effectiveness of Linagliptin

Condition:   Diabetes Mellitus, Type 2
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage (The PATCH Study)

Conditions:   Wounds and Injuries;   Acute Coagulopathy
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsors:   National Trauma Research Institute;   National Health and Medical Research Council, Australia
Recruiting - verified April 2015

HealthMap: an Interactive Health Plan Randomised Trial to Prevent Cardiovascular Disease in People With HIV

Conditions:   HIV;   Cardiovascular Disease
Intervention:   Other: Integrated self management support
Sponsors:   Karen Klassen;   Alfred Health;   Monash University;   Australasian Society for HIV Medicine;   National Association for People with HIV Australia;   National Health and Medical Research Council, Australia;   Victorian AIDS Council;   Department of Health, Victoria;   Flinders University;   Living Positive Victoria;   New South Wales Ministry of Health;   University of Melbourne;   Deakin University
Recruiting - verified April 2015

Immunological Profile in Relation to Cardiac Geometry in Hypertension

Condition:   Immune System Profile During Hypertensive Cardiac Remodeling
Intervention:  
Sponsor:   Neuromed IRCCS
Recruiting - verified April 2015

Post-Stroke Disease Management - Stroke Card

Conditions:   Stroke;   Ischemic Attack, Transient;   Secondary Prevention;   Disease Management;   Cost-Benefit Analysis
Interventions:   Behavioral: Active Comparator: Extended Standard Care (Stroke Card);   Behavioral: Active Comparator: Standard Care
Sponsors:   Medical University Innsbruck;   Center of Excellence in Medicine and IT (CEMIT);   Tiroler Landeskrankenanstalten GmbH (TILAK);   Tiroler Gebietskrankenkasse (TGKK);   Tiroler Gesundheitsfonds (TGF);   Private Universität für Gesundheitswissenschaften, Medizinische Informatik und Technik (UMIT)
Recruiting - verified April 2015

Ascertainment of EMR-based Clinical Covariates Among Patients Receiving Oral and Non-insulin Injected Hypoglycemic Therapy

Condition:   Diabetes Mellitus, Type 2
Intervention:  
Sponsor:   Boehringer Ingelheim
Completed - verified April 2015

A Phase 2b Study of CSL112 in Subjects With Acute Myocardial Infarction.

Condition:   Acute Myocardial Infarction
Interventions:   Biological: CSL112;   Biological: Placebo
Sponsor:   CSL Behring
Recruiting - verified April 2015

Combined Bronchodilators in Chronic Obstructive Pulmonary Disease and the Risk of Adverse Cardio-pulmonary Events

Condition:   Pulmonary Disease, Chronic Obstructive
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting - verified April 2015

Registry of Non-primary Angioplasty at Hospitals Without Surgery On-site

Conditions:   Coronary Artery Disease;   Heart Attack;   Angina
Intervention:  
Sponsor:   Johns Hopkins University
Recruiting - verified April 2015

Sequential Expansion of Comparative Effectiveness of Anticoagulants

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

Angioshield First-In-Human Study to Demonstrate the Preliminary Safety and Efficacy

Condition:   Coronary Artery Disease
Intervention:   Device: Angioshield
Sponsor:   Neograft Technologies, Incorporated
Active, not recruiting - verified April 2015

HIP Fracture Accelerated Surgical TreaTment And Care tracK (HIP ATTACK) Trial

Condition:   Hip Fractures
Intervention:   Other: Accelerated medical clearance and surgery
Sponsors:   Population Health Research Institute;   McMaster University
Recruiting - verified April 2015

Reduction in Infarct Size by Remote Per-postconditioning in Patients With ST-elevation Myocardial Infarction

Conditions:   Coronary Artery Disease;   Myocardial Infarction
Intervention:   Procedure: Primary Percutaneous Coronary Intervention
Sponsor:   John Pernow
Recruiting - verified April 2015

Nelfinavir in Systemic Lupus Erythematosus

Condition:   Systemic Lupus Erythematosus
Intervention:   Drug: Nelfinavir
Sponsors:   North Shore Long Island Jewish Health System;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified April 2015

Verification of the Safety of Early Discharge in Patients After Acute ST-segment Myocardial Infarction

Conditions:   Coronary Artery Disease;   Acute Myocardial Infarction With ST-segment Elevation;   Primary Percutaneous Coronary Intervention;   Early Discharge
Interventions:   Other: Early discharge;   Other: Standard discharge
Sponsor:   Kamil Novobílský
Recruiting - verified April 2015

Cardiovascular Outcomes Following Treatment With Ertugliflozin in Participants With Type 2 Diabetes Mellitus and Established Vascular Disease (MK-8835-004)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Ertugliflozin;   Drug: Placebo
Sponsors:   Merck Sharp & Dohme Corp.;   Pfizer
Recruiting - verified April 2015

Single Session Percutaneous Mechanical Thrombectomy for the Treatment of Ilio-femoral Deep Vein Thrombosis: A Preliminary Evaluation

Conditions:   Deep Vein Thrombosis;   Venous Thromboembolism
Intervention:   Device: Thrombectomy
Sponsor:   Ottawa Hospital Research Institute
Terminated - verified April 2015

The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified April 2015

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified April 2015

Post Acute Coronary Event Smoking Study

Conditions:   Smoking Cessation;   Acute Coronary Syndrome
Interventions:   Behavioral: Behavioral Activation (BA);   Behavioral: Standard Smoking Cessation Counseling;   Drug: Nicotine patch;   Other: Printed Self-help materials for Smoking Cessation
Sponsor:   The Miriam Hospital
Active, not recruiting - verified April 2015

A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Events

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: insulin degludec;   Drug: insulin glargine
Sponsor:   Novo Nordisk A/S
Active, not recruiting - verified April 2015

Colchicine in ST-elevation Myocardial Infarction

Condition:   Acute Myocardial Infarction
Interventions:   Drug: Colchicine 2 mg loading dose; 0.5 mg bid for 5 days;   Drug: Placebo
Sponsor:   G.Gennimatas General Hospital
Recruiting - verified April 2015

GLORIA-AF Registry Program (Phase II/III)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

Study of GSK1278863 to Reduce Ischemic Events in Patients Undergoing Thoracic Aortic Aneurysm Repair

Condition:   Surgical Procedures
Interventions:   Drug: GSK1278863;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Completed - verified April 2015

PWV for Cardiovascular Complication After Cardiac Surgery

Condition:   C.Surgical Procedure; Cardiac
Intervention:  
Sponsors:   Seoul National University Hospital;   SMG-SNU Boramae Medical Center
Completed - verified April 2015

ENDOvascular Interventions With AngioMAX: The ENDOMAX Trial

Condition:   Peripheral Endovascular Interventions
Intervention:   Drug: Bivalirudin
Sponsor:   The Medicines Company
Recruiting - verified July 2014

A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure

Conditions:   Heart Failure;   Coronary Artery Disease
Interventions:   Drug: Rivaroxaban;   Drug: Placebo;   Other: Standard of care for heart failure and coronary artery disease
Sponsors:   Janssen Research & Development, LLC;   Bayer
Recruiting - verified April 2015

Non-interventional Local Study on Prescription Behavior of Anticoagulation Therapy in Secondary Stroke Prevention in Atrial Fibrillation Patients

Conditions:   Stroke,;   Embolism
Intervention:   Other: Rivaroxaban ( Xarelto, BAY59-7939)
Sponsor:   Bayer
Recruiting - verified April 2015

Preventing Stem Cell Transplant Complications With a Blood Separator Machine

Conditions:   MDS (Myelodysplastic Syndrome);   Myeloproliferative Disorder;   Lymphoma, Non-Hodgkin;   ALL (Acute B-Lymphoblastic Leukemia);   AML (Acute Meylogenous Leukemia
Intervention:   Device: Graft Manipulation (CD34+ Selection)
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 2015

Antibody Treatment for Advanced Celiac Disease

Conditions:   Celiac Disease;   Celiac Sprue;   Gluten Enteropathy;   Gluten-Sensitive Enteropathy
Intervention:   Biological: Hu-Mik- Beta-1
Sponsors:   National Cancer Institute (NCI);   Mayo Clinic
Recruiting - verified March 2015

Incremental Value of Point of Care H-FABP Testing in Primary Care Patients Suspected of Acute Coronary Syndrome

Conditions:   Acute Coronary Syndrome;   Angina Pectoris, Unstable;   Angina Pectoris, Stable;   Thoracic Diseases
Intervention:   Device: heart type fatty acid binding protein testing
Sponsors:   Maastricht University Medical Center;   FABPulous B.V.
Recruiting - verified April 2015

Sirolimus Eluting ORSIRO Stent Versus Biolimus-eluting NOBORI Stent

Conditions:   Coronary Artery Disease;   Ischemic Heart Disease
Intervention:   Device: Drug-eluting stent
Sponsor:   Odense University Hospital
Active, not recruiting - verified April 2015

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention & Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute
Recruiting - verified April 2015

Safety and Feasibility of Using a Single Transradial Guiding Catheter for Primary PCI

Condition:   Myocardial Infarction
Interventions:   Procedure: guiding catheter;   Procedure: diagnostic catheter
Sponsor:   Beijing Luhe Hospital
Active, not recruiting - verified April 2015

Homebased Training With Telemonitoring Guidance in Low to Moderate Risk Patients Entering Cardiac Rehabilitation

Conditions:   Acute Coronary Syndrome;   Myocardial Infarction
Interventions:   Behavioral: Home-based training;   Behavioral: Centre-based training
Sponsor:   Maxima Medical Center
Active, not recruiting - verified April 2015

Intracoronary Autologous Mesenchymal Stem Cells Implantation in Patients With Ischemic Dilated Cardiomyopathy

Condition:   Ischemic Dilated Cardiomyopathy
Intervention:   Other: BM-MSCs
Sponsors:   National University of Malaysia;   Cytopeutics Sdn Bhd
Active, not recruiting - verified April 2015

STOP-AUST: The Spot Sign and Tranexamic Acid On Preventing ICH Growth - AUStralasia Trial

Conditions:   Intracerebral Haemorrhage;   Stroke
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsor:   Neuroscience Trials Australia
Recruiting - verified September 2014

Long-term Clinical Outcome in Patients Undergoing Remote Ischemic Conditioning Before Primary Percutaneous Coronary Intervention for ST-elevation Myocardial Infarction: a Follow-up Study

Condition:   ST-elevation Myocardial Infarction (STEMI)
Intervention:   Procedure: Remote ischemic perconditioning
Sponsors:   University of Aarhus;   Aarhus University Hospital;   Oxford University Hospitals NHS Trust;   The Hospital for Sick Children
Active, not recruiting - verified August 2013

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

CYCLosporinE A in Reperfused Acute Myocardial Infarction

Condition:   Acute Myocardial Infarction
Intervention:   Drug: Cyclosporine A
Sponsors:   Mario Negri Institute for Pharmacological Research;   Heart Care Foundation
Completed - verified October 2013

Adverse Effects of Systemic Hypoglycemia Exposure on Endothelial Function in Humans

Condition:   Type 2 Diabetes
Intervention:   Other: Glycemic clamping
Sponsor:   Medical College of Wisconsin
Terminated - verified April 2015

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab SAR236553 (REGN727)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Other: placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified April 2015

The Supplementary Role of Non-invasive Imaging to Routine Clinical Practice in Suspected Non-ST-elevation Myocardial Infarction

Conditions:   Chest Pain;   Myocardial Infarction;   Acute Coronary Syndrome;   Coronary Artery Disease;   Myocardial Ischemia
Interventions:   Other: Cardiovascular Magnetic Resonance Imaging;   Other: Computed Tomography Angiography
Sponsors:   Maastricht University Medical Center;   Dutch Heart Foundation
Recruiting - verified April 2015

Shortened Aggrastat® Versus Integrilin in Percutaneous Coronary Intervention

Conditions:   Myocardial Infarction;   Acute Coronary Syndromes;   Unstable Angina
Interventions:   Drug: Short Tirofiban;   Drug: Eptifibatide;   Drug: Long Tirofiban
Sponsors:   Medicure;   SCRI Development Innovations, LLC
Recruiting - verified April 2015

Cyclosporine and Prognosis in Acute Myocardial Infarction (MI) Patients

Condition:   ST Elevation Acute Myocardial Infarction
Interventions:   Drug: Injection of Cyclosporin;   Drug: Placebo;   Procedure: Echocardiography
Sponsor:   Hospices Civils de Lyon
Active, not recruiting - verified April 2015

Step Monitoring to Improve ARTERial Health

Conditions:   Type 2 Diabetes;   Hypertension
Interventions:   Behavioral: Step count prescription;   Behavioral: Usual care
Sponsors:   McGill University Health Center;   Canadian Institutes of Health Research  (CIHR)
Active, not recruiting - verified April 2015

GLORIA-AF Registry Program - Second and Third Phases

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting - verified April 2015

Randomized, Open Label Trial of 6 Months Versus 12 Months DAPT After Drug-Eluting Stent in STEMI

Conditions:   Myocardial Infarction;   Cardiovascular Disease
Interventions:   Other: 6 months DAPT;   Other: 12 months DAPT
Sponsors:   Maasstad Hospital;   Medtronic
Recruiting - verified April 2015

A Open-Label Study Of CP-690,550 As Long-Term Therapy (48 Weeks) In Subjects With Crohn's Disease

Condition:   Crohn's Disease
Interventions:   Drug: CP-690,550;   Drug: CP-690,550
Sponsor:   Pfizer
Recruiting - verified April 2015

Vest Prevention of Early Sudden Death Trial and VEST Registry

Conditions:   Myocardial Infarction;   Ventricular Dysfunction;   Sudden Death;   Ventricular Tachycardia;   Ventricular Fibrillation
Intervention:   Device: wearable defibrillator
Sponsors:   University of California, San Francisco;   Zoll Medical Corporation
Recruiting - verified April 2015

The "Virtual" Multicenter Spontaneous Coronary Artery Dissection (SCAD) Registry

Conditions:   Spontaneous Coronary Artery Dissection;   SCAD
Intervention:  
Sponsor:   Mayo Clinic
Recruiting - verified April 2015

ABSORB II Randomized Controlled Trial

Condition:   Coronary Artery Disease
Interventions:   Device: Abbott Vascular XIENCE Everolimus Eluting Coronary Stent System;   Device: Abbott Vascular ABSORB Everolimus Eluting Bioresorbable Vascular Scaffold System
Sponsor:   Abbott Vascular
Active, not recruiting - verified April 2015

Hyper-CVAD and Ponatinib in Ph-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia (ALL)

Condition:   Leukemia
Interventions:   Drug: Cyclophosphamide;   Drug: Mesna;   Drug: Doxorubicin;   Drug: Vincristine;   Drug: Dexamethasone;   Drug: Ponatinib;   Drug: G-CSF  (Filgrastim);   Drug: Rituximab;   Drug: Methotrexate;   Drug: Cytarabine;   Drug: Solu-medrol ( Methyl Prednisolone);   Drug: Citrovorum (Leucovorin);   Drug: Prednisone;   Drug: Pegfilgrastim (Neulasta)
Sponsors:   M.D. Anderson Cancer Center;   Ariad Pharmaceuticals
Recruiting - verified April 2015

Fondaparinux EU-RMP (Adherence)

Conditions:   ST-elevation Myocardial Infarction;   Unstable Angina;   Non ST Segment Elevation Myocardial Infarction;   Acute Coronary Syndrome
Intervention:   Drug: fondaparinux
Sponsor:   GlaxoSmithKline
Completed - verified April 2015

Comparison Between FFR Guided Revascularization Versus Conventional Strategy in Acute STEMI Patients With MVD.

Conditions:   Myocardial Infarction;   Multivessel Coronary Artery Disease
Interventions:   Procedure: FFR-guided revascularisation strategy;   Procedure: randomised to guidelines group
Sponsors:   Maasstad Hospital;   Abbott Vascular;   St. Jude Medical
Recruiting - verified April 2015

Clearance Of Mucus In Stents

Conditions:   Lung Neoplasms;   Respiratory Failure;   Pneumonia;   Acute Coronary Syndromes;   Unstable Angina;   Myocardial Infarction;   Cardiac Arrhythmia;   Thromboembolic Disease
Interventions:   Other: Normal Saline;   Other: Sodium Bicarbonate
Sponsor:   M.D. Anderson Cancer Center
Recruiting - verified April 2015

Stress Echocardiography and Heart Computed Tomography (CT) Scan in Emergency Department Patients With Chest Pain

Conditions:   Chest Pain;   Angina;   Angina Pectoris;   Coronary Artery Disease
Interventions:   Procedure: Stress Echocardiography;   Procedure: Coronary CT Angiography
Sponsors:   Montefiore Medical Center;   American Heart Association
Recruiting - verified April 2015

Drug Drug Interactions of Aspirin and P2Y12-inhibitors

Conditions:   VA Drug Interactions [VA Drug Interaction];   Myocardial Infarction
Interventions:   Drug: Morphine;   Drug: Placebo
Sponsor:   Medical University of Vienna
Completed - verified April 2015

Survival After First Myocardial Infarction in Patients With and Without Chronic Obstructive Pulmonary Disease

Conditions:   Myocardial Infarction;   Chronic Obstructive Pulmonary Disease
Intervention:  
Sponsors:   London School of Hygiene and Tropical Medicine;   British Medical Research Council;   University College, London
Completed - verified April 2015

Resolute Zotarolimus-Eluting Stent Versus the Taxus Liberte Paclitaxel-Eluting Stent for Percutaneous Coronary Intervention in China

Conditions:   Ischemic Heart Disease;   Stenotic Coronary Lesion;   Cardiovascular Diseases;   Arteriosclerosis;   Coronary Artery Disease
Interventions:   Device: Taxus Liberte Paclitaxel-Eluting Coronary Stent System;   Device: Resolute Zotarolimus-Eluting Coronary Stent System
Sponsor:   Medtronic Vascular
Active, not recruiting - verified April 2015

Aggrastat Truncated Length Against Standard Therapies in Percutaneous Coronary Intervention

Conditions:   Myocardial Infarction;   Acute Coronary Syndromes;   Unstable Angina;   Percutaneous Coronary Intervention
Interventions:   Drug: Tirofiban (Aggrastat);   Drug: Placebo
Sponsors:   Medicure;   SCRI Development Innovations, LLC
Suspended - verified April 2015

Evaluation of the Endeavor Resolute Zotarolimus-Eluting Coronary Stent System in a Real-World Patient Population in China

Conditions:   Ischemic Heart Disease;   Stenotic Coronary Lesion;   Cardiovascular Diseases;   Arteriosclerosis;   Coronary Artery Disease
Intervention:  
Sponsor:   Medtronic Vascular
Active, not recruiting - verified April 2015

Study to Develop a Non-invasive Marker for Monitoring Myocardial Fibrosis

Conditions:   Hypertrophic Cardiomyopathy;   Acute Coronary Syndrome
Intervention:   Radiation: 99mTc-NC100692
Sponsor:   Ottawa Heart Institute Research Corporation
Active, not recruiting - verified April 2015

EXCEL Clinical Trial

Conditions:   Chronic Coronary Occlusion;   Unprotected Left Main Coronary Artery Disease;   Stent Thrombosis;   Vascular Disease;   Myocardial Ischemia;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Artery Disease;   Coronary Restenosis
Interventions:   Device: Percutaneous Coronary Intervention;   Procedure: CABG
Sponsor:   Abbott Vascular
Active, not recruiting - verified April 2015

A Pilot Study of CPAP Adherence Promotion by Peer Buddies With Sleep Apnea

Condition:   Sleep Apnea
Interventions:   Behavioral: Peer-driven intervention;   Other: Usual Care
Sponsor:   Department of Veterans Affairs
Completed - verified February 2013

RESOLUTE Asia: Evaluation of the Endeavor Resolute Zotarolimus-Eluting Stent System in a Patient Population With Long Lesion(s) and/or Dual Vessels in Asia

Conditions:   Ischemic Heart Disease;   Stenotic Coronary Lesion;   Cardiovascular Diseases;   Arteriosclerosis;   Coronary Artery Disease
Intervention:   Device: Drug eluting stent treatment
Sponsor:   Medtronic Vascular
Active, not recruiting - verified April 2015

Drug-Eluting Stents vs. Bare Metal Stents In Saphenous Vein Graft Angioplasty

Condition:   Saphenous Vein Graft Atherosclerosis
Interventions:   Device: Bare Metal Stent;   Device: Drug-Eluting Stent;   Drug: Blinded clopidogrel;   Drug: Placebo;   Drug: Thienopyridine (open-label)
Sponsor:   Department of Veterans Affairs
Recruiting - verified April 2015

Study Comparing CT Scan and Stress Test in Patients With Known Coronary Artery Disease Hospitalized for Chest Pain

Conditions:   Coronary Artery Disease;   Angina Pectoris;   Unstable Angina;   Acute Coronary Syndrome
Interventions:   Procedure: Coronary CT angiography;   Procedure: Myocardial perfusion imaging
Sponsors:   Montefiore Medical Center;   Albert Einstein College of Medicine of Yeshiva University
Terminated - verified April 2015

Troponin T as Risk Stratification Tool in Peripheral Arterial Occlusive Disease

Condition:   Peripheral Arterial Occlusive Disease
Intervention:  
Sponsors:   Heart Center Bad Krozingen;   Johann Wolfgang Goethe University Hospitals
Completed - verified April 2015

PeriOperative ISchemic Evaluation-2 Trial

Condition:   Cardiovascular Disease
Interventions:   Drug: Active Clonidine;   Drug: Placebo Clonidine;   Drug: Active ASA;   Drug: Placebo ASA
Sponsors:   Hamilton Health Sciences Corporation;   McMaster University
Completed - verified April 2015

Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial

Condition:   Ischemic Attack, Transient
Interventions:   Drug: Clopidogrel;   Drug: placebo
Sponsors:   University of California, San Francisco;   Neurological Emergencies Treatment Trials Network (NETT);   Medical University of South Carolina;   The EMMES Corporation
Recruiting - verified April 2015

Angiotensin-converting-enzyme (ACE) Inhibitors in Hemodialysis

Conditions:   Left Ventricular Hypertrophy;   Hypertension
Interventions:   Drug: ACE inhibitor Ramipril;   Drug: non-RAS inhibitor antihypertensive therapy
Sponsors:   Mario Negri Institute for Pharmacological Research;   Agenzia Italiana del Farmaco
Active, not recruiting - verified April 2015

A Randomized, Placebo-Controlled, Double-Blind Pilot Study of Pioglitazone Hydrochloride in Severe, Refractory Asthma

Conditions:   Severe, Refractory Asthma;   Airway Inflammation;   Airflow Obstruction
Intervention:   Drug: Pioglitazone
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2015

Efficacy and Cost-Effectiveness of Cost-free Pharmacotherapy for Smoking Cessation for High-risk Smokers With Cerebrovascular Disease

Conditions:   Cerebrovascular Disorders;   Smoking Cessation
Interventions:   Drug: Cost-Free Pharmacotherapy Group;   Other: Prescription Only Group
Sponsors:   Ottawa Heart Institute Research Corporation;   Heart and Stroke Foundation of Ontario
Completed - verified April 2015

Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation

Conditions:   Mitral Valve Insufficiency;   Coronary Artery Disease
Interventions:   Procedure: Mitral Valve Repair with Annuloplasty;   Procedure: Mitral Valve Replacement
Sponsors:   Mount Sinai School of Medicine;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research  (CIHR);   National Institute of Neurological Disorders and Stroke (NINDS)
Completed - verified April 2015

Evaluation of Varenicline (Champix) in Smoking Cessation for Patients Post-Acute Coronary Syndrome (EVITA) Trial

Condition:   Acute Coronary Syndrome
Interventions:   Drug: varenicline;   Other: placebo
Sponsors:   Mark Eisenberg;   St. Michael's Hospital, Toronto;   Sunnybrook Health Sciences Centre;   Queen Elizabeth II Health Sciences Centre
Active, not recruiting - verified April 2015

Study Comparing CT Scan and Stress Test in Diagnosing Coronary Artery Disease in Patients Hospitalized for Chest Pain

Conditions:   Coronary Artery Disease;   Angina Pectoris;   Unstable Angina;   Acute Coronary Syndrome
Interventions:   Procedure: Coronary Computed Tomography Angiography;   Procedure: Stress Nuclear Myocardial Perfusion Imaging
Sponsors:   Montefiore Medical Center;   American Heart Association;   Albert Einstein College of Medicine of Yeshiva University
Completed - verified April 2015

Natural Killer Cells and Bortezomib to Treat Cancer

Conditions:   Lung or Prostatic Neoplasms;   Colorectal or Kidney Neoplasms;   Pancreatic Neoplasms;   Leukemia, Myelogenous, Chronic Lymphocytic Leukemia, BCR-ABL Positive;   Melanoma;   CLL
Intervention:   Drug: NK cells +CliniMACs CD3 and CD56 systems
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2015

Montelukast to Treat Bronchiolitis Obliterans

Conditions:   Bronchiolitis Obliterans;   Chronic Graft Versus Host Disease;   Leukotriene;   Montelukast;   Stem Cell Transplant
Intervention:   Drug: Singular (Montelukast Sodium)
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting - verified March 2015

Vascular Events In Noncardiac Surgery Patients Cohort Evaluation Study (VISION)

Conditions:   Vascular Death;   Myocardial Infarction;   Cardiac Arrest;   Stroke
Intervention:  
Sponsors:   Hamilton Health Sciences Corporation;   Roche Diagnostic Ltd.;   Heart and Stroke Foundation of Ontario;   Population Health Research Institute;   Ontario Ministry of Research and Innovation;   McMaster University;   CLARITY Group
Completed - verified April 2015

Preventing ESRD in Overt Nephropathy of Type 2 Diabetes

Condition:   Diabetes
Interventions:   Drug: Benazepril;   Drug: Valsartan;   Drug: Benazepril/Valsartan
Sponsors:   Mario Negri Institute for Pharmacological Research;   Agenzia Italiana del Farmaco
Active, not recruiting - verified April 2015

Heart Outcomes Prevention Evaluation-3

Conditions:   Cardiovascular Disease;   Stroke
Interventions:   Drug: Candesartan/HCT;   Drug: Rosuvastatin
Sponsor:   Population Health Research Institute
Active, not recruiting - verified April 2015

Effects Of Atorvastatin On Macrophage Activity And Plaque Inflammation Using Magnetic Resonance Imaging

Conditions:   Atherosclerotic Carotid Disease;   Atheroma;   Atherosclerosis
Intervention:   Drug: atorvastatin
Sponsor:   GlaxoSmithKline
Completed - verified April 2015

Causes and Natural History of Dyslipidemias

Condition:   Dyslipidemias
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2015

Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen

Condition:   Arthritis, Rheumatoid
Interventions:   Drug: celecoxib;   Drug: Ibuprofen;   Drug: Naproxen
Sponsors:   Pfizer;   The Cleveland Clinic
Active, not recruiting - verified April 2015

Scleroderma: Cyclophosphamide or Transplantation (SCOT)

Conditions:   Scleroderma, Systemic;   Sclerosis;   Autoimmune Disease
Interventions:   Procedure: Autologous stem cell transplantation;   Drug: Cyclophosphamide;   Drug: Antithymocyte globulin, equine;   Drug: Methylprednisolone;   Drug: Growth colony stimulating factor (G-CSF);   Radiation: Total body irradiation (TBI)
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Active, not recruiting - verified April 2015

Evaluation of Lipoproteins

Conditions:   Hyperlipidemia;   Hyperlipoproteinemia;   Hypolipoproteinemia
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2015

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