Heart Attack

Clinical Trial Finder

Many patients with heart disease are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

MiSaver® Stem Cell Treatment for Heart Attack (Acute Myocardial Infarction)

Condition:   Myocardial Infarction
Intervention:   Biological: MiSaver®
Sponsors:   Honya Medical Inc;   Chung Shan Medical University
Recruiting

French Registry of Acute ST-elevation or Non-ST-elevation Myocardial Infarction 2015

Condition:   Myocardial Infarction
Intervention:  
Sponsors:   French Cardiology Society;   Assistance Publique - Hôpitaux de Paris
Active, not recruiting

French Cohort of Myocardial Infarction Evaluation

Condition:   Acute Myocardial Infarction
Intervention:  
Sponsors:   Assistance Publique - Hôpitaux de Paris;   National Research Agency, France
Recruiting

Prospective Outpatient Registry of Myocardial Infarction Patients

Condition:   Myocardial Infarction
Intervention:  
Sponsor:   National Research Center for Preventive Medicine
Active, not recruiting

Efficacy and Safety of Adjunctive Cilostazol in Acute Myocardial Infarction Patients

Condition:   Acute Myocardial Infarction
Intervention:   Drug: antiplatelet therapy
Sponsor:   Korea University Guro Hospital
Recruiting

Hs-cTn - Optimizing the Diagnosis of Acute Myocardial Infarction/Injury in Women

Conditions:   Myocardial Infarction;   Sex Differences;   High Sensitivity Troponin
Intervention:   Diagnostic Test: Introduction of a lower female hs-cTn cut-point
Sponsors:   BC Centre for Improved Cardiovascular Health;   Canadian Institutes of Health Research (CIHR)
Not yet recruiting

Clinical Presentation and Outcomes in Patients at Risk of Type II Myocardial InfarctioN in the emerGency Department.

Conditions:   Myocardial Oxygenation Imbalance;   Myocardial Infarction
Intervention:   Other: Follow-up
Sponsor:   Hospices Civils de Lyon
Recruiting

Myocardial Infarction, COmbined-device, Recovery Enhancement Study

Conditions:   Acute Myocardial Infarction;   Coronary Artery Disease;   Acute Coronary Syndrome;   Myocardial Infarction
Intervention:   Device: Corrie Digital Health platform
Sponsors:   Johns Hopkins University;   Apple Inc.;   iHealth
Active, not recruiting

Impact of Peripheral Vascular Stiffness Assessment on Risk Prediction in Patients With Myocardial Infarction

Conditions:   Myocardial Infarction;   Vascular Stiffness;   Heart Failure
Intervention:   Other: Imaging evaluation for vascular assessment
Sponsors:   University Hospital, Lille;   Fédération Française de Cardiologie;   Merck Sharp & Dohme Corp.
Not yet recruiting

Coronary Angiography in Critically Ill Patients With Type II Myocardial Infarction

Conditions:   Type 2 Myocardial Infarction;   Coronary Artery Disease;   Percutaneous Coronary Intervention;   Critical Illness
Intervention:   Procedure: percutaneous coronary intervention (stenting)
Sponsor:   University Medical Centre Ljubljana
Not yet recruiting

Evaluate the Safety and Explore Efficacy of Umbilical Cord Mesenchymal Stem Cells in Acute Myocardial Infarction

Condition:   Acute Myocardial Infarction
Intervention:   Biological: Allogeneic umbilical cord mesenchymal stem cells
Sponsor:   Ever Supreme Bio Technology Co., Ltd.
Recruiting

Long-term Clinical Outcomes of intraVascular Ultrasound-guided vs Angiography-guided Primary pErcutaneous Intervention in Patients With Acute ST Segment Elevated Myocardial Infarction

Condition:   ST Elevation Myocardial Infarction
Interventions:   Procedure: IVUS-guided PCI;   Procedure: Angiography-guided PCI
Sponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Ningbo No. 1 Hospital
Not yet recruiting

Effect of Vitamin D on Ventricular Remodeling in Patients With Acute Myocardial Infarction (VITDAMI)

Condition:   Myocardial Infarction
Interventions:   Drug: Calcifediol;   Drug: Placebo
Sponsors:   Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz;   Fondo de Investigacion Sanitaria;   Spanish Society of Cardiology
Recruiting

Prokinecitine in Acute Myocardial Infarction

Condition:   ST Elevatation Myocardial Infarction (STEMI)
Intervention:  
Sponsor:   University Hospital, Strasbourg, France
Terminated

A Study to Evaluate the Safety and Efficacy of MEDI6012 in Acute ST Elevation Myocardial Infarction

Condition:   ST Elevation Myocardial Infarction
Interventions:   Biological: MEDI6012;   Other: Placebo
Sponsors:   MedImmune LLC;   Thrombolysis in Myocardial Infarction (TIMI) Study Group
Recruiting

Smartphone Twelve Lead Electrocardiogram Utility In ST Elevation Myocardial Infarction

Condition:   ST Elevated Myocardial Infarction
Intervention:   Device: Alivecor Heart Monitor
Sponsor:   INTEGRIS Baptist Medical Center
Completed

Complete Lesion Versus Culprit Lesion Revascularization

Condition:   Myocardial Infarction
Interventions:   Procedure: complete revascularization;   Procedure: Culprit revasularization
Sponsor:   Korea University Guro Hospital
Temporarily not available

Impact of Morphine Treatment on Platelet Inhibition in Acute Myocardial Infarction

Condition:   Acute Myocardial Infarction
Interventions:   Drug: Morphinhydrochloricum;   Drug: Metoclopramide;   Drug: Ticagrelor;   Drug: Isotonic sodium chloride
Sponsor:   University of Luebeck
Completed

A Medical Research Study to Evaluate the Effects of ACT-246475 in Adults With Heart Attack

Condition:   Acute Myocardial Infarction
Intervention:   Drug: ACT-246475
Sponsor:   Idorsia Pharmaceuticals Ltd.
Completed

MULTivessel Immediate Versus STAged RevaScularization in Acute Myocardial Infarction -The MULTISTARS AMI Trial

Conditions:   ST-elevation Myocardial Infarction;   Multivessel Coronary Disease
Interventions:   Procedure: Staged complete PCI;   Procedure: Immediate complete PCI;   Device: Synergy™ stent
Sponsor:   University of Zurich
Recruiting

A Trial Evaluating Vitamin D Normalization on Major Adverse Cardiovascular-Related Events Among Myocardial Infarction Patients

Conditions:   Death;   Myocardial Infarction;   Cerebral Vascular Accident;   Heart Failure Hospitalization
Intervention:   Biological: Vitamin D3
Sponsor:   Intermountain Health Care, Inc.
Recruiting

The Effect of Glucocorticoid Therapy on Left Ventricular Remodelling in Acute Myocardial Infarction (RECONSIDER)

Conditions:   ST-segment Elevation Myocardial Infarction;   Left Ventricular Remodeling
Interventions:   Drug: Hydrocortisone;   Drug: Placebo
Sponsors:   Iuliu Hatieganu University of Medicine and Pharmacy;   Romanian Governmental Funding (UEFISCDI)
Recruiting

Mechanical Complications of Acute Myocardial Infarction

Conditions:   Post-Infarction Heart Rupture;   Post-Infarction Ventricular Septal Defect;   Post-Infarction Mitral Papillary Muscle Rupture
Intervention:   Procedure: Surgery for mechanical complications of acute myocardial infarction
Sponsor:   Maastricht University Medical Center
Recruiting

Adherence to Prescribed Medication: Elucidating the Gap Between Guideline Recommendation and Real Life in Myocardial Infarction

Conditions:   Myocardial Infarction;   Adherence, Medication
Intervention:   Other: Investigating Adherence to Standard of Care Medication and Cardiac Rehabilitation
Sponsor:   Medical University of Vienna
Recruiting

Study of Dutogliptin in Combination With Filgrastim in Post-Myocardial Infarction

Conditions:   Acute Myocardial Infarction;   Acute Myocardial Ischemia;   STEMI - ST Elevation Myocardial Infarction
Interventions:   Drug: Dutogliptin Tartrate;   Drug: Filgrastim Injectable Product;   Drug: Placebos
Sponsor:   Recardio, Inc.
Enrolling by invitation

Predicting Ventricular Tachyarrhythmias Following Acute ST Elevation Myocardial Infarction

Condition:   Risk Stratification
Intervention:   Other: Diagnostic
Sponsor:   Clinical Centre of Serbia
Recruiting

Functional Assessment in Elderly MI Patients With Multivessel Disease

Condition:   Myocardial Infarction
Interventions:   Other: Culprit-only revascularization;   Other: Complete functionally-guided revascularization
Sponsor:   Consorzio Futuro in Ricerca
Recruiting

Aerobic Interval Training v/s Resistance Interval Training On Ejection Fraction In Stable Post MI Patients

Condition:   Myocardial Infarction
Interventions:   Other: Aerobic Interval Training;   Other: Aerobic + Resistive Interval Training
Sponsor:   Riphah International University
Completed

IdeNtifying High riSk Patients Post Myocardial Infarction With REduced Left Ventricular Function Using External Loop Recorders (INSPIRE-ELR Study)

Condition:   Post MI Left Ventricular Dysfunction
Intervention:   Device: External Loop Recorder
Sponsors:   Medtronic BRC;   Medtronic
Completed

Strut Coverage With SYNERGY Stents and Bioresorbable Vascular Scaffold in Acute Myocardial Infarction

Condition:   Acute Coronary Syndrome
Interventions:   Device: SYNERGY stent;   Device: ABSORB (Everolimus-eluting Bioresorbable Vascular Scaffold)
Sponsors:   University Hospital, Toulouse;   Boston Scientific Corporation
Completed

Sleep Disordered Breathing (SDB) Prevalence and Cardiovascular Outcomes of Myocardial Infarction (MI) Survivors

Conditions:   Acute Myocardial Infarction;   Sleep Apnea
Intervention:   Diagnostic Test: Polygraphy
Sponsors:   Assistance Publique - Hôpitaux de Paris;   National Research Agency, France
Recruiting

Shortened Aggrastat® Versus Integrilin in Percutaneous Coronary Intervention

Conditions:   Myocardial Infarction;   Acute Coronary Syndromes;   Unstable Angina
Interventions:   Drug: Short Tirofiban;   Drug: Eptifibatide;   Drug: Long Tirofiban
Sponsors:   Medicure;   SCRI Development Innovations, LLC
Completed

Post Infarction Exercise Effects on Myocardial Function Assessed by 2D Strain Ultrasound

Condition:   Myocardial Infarction
Intervention:   Other: Cardiac training program
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Active, not recruiting

French Registry of Acute Coronary Syndrome With or Without ST Elevation 2010

Conditions:   Myocardial Infarction;   Acute Coronary Syndrome
Intervention:  
Sponsor:   French Cardiology Society
Active, not recruiting

Monitoring Glucose Levels in Patients With Myocardial Infarction

Conditions:   Acute Coronary Syndromes;   Hyperglycemia;   Hypoglycemia
Intervention:   Device: OptiScanner®
Sponsors:   Lars Ryden;   Karolinska Institutet;   Swedish Heart Lung Foundation
Terminated

Feasibility of the "Heart-track" Rehabilitative Device Prototype

Conditions:   Cardiac Infarct;   Cardiac Event
Intervention:   Device: Heart Track
Sponsor:   Tan Tock Seng Hospital
Completed

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk

Condition:   Dyslipidemia
Interventions:   Biological: Evolocumab;   Drug: Placebo
Sponsor:   Amgen
Completed

ACCESS to the Cardiac Cath Lab in Patients Without STEMI Resuscitated From Out-of-hospital VT/VF Cardiac Arrest

Conditions:   Cardiac Arrest Due to Underlying Cardiac Condition;   Ventricular Fibrillation;   Cardiopulmonary Arrest With Successful Resuscitation
Interventions:   Procedure: Initial CCL admission;   Diagnostic Test: Initial ICU admission
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Active, not recruiting

ACS Registry - A Non-interventional Study to Estimate the Rates of Outcomes in ACS Patients in Moscow

Conditions:   Heart Attack;   Stroke;   Cardiovascular Death
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Transfusion Trigger After Operations in High Cardiac Risk Patients

Conditions:   Myocardial Infarction;   Coronary Revascularization;   Acute Renal Failure
Intervention:   Procedure: Blood Transfusion
Sponsor:   VA Office of Research and Development
Recruiting

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention & Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Population Health Research Institute;   Janssen Research & Development, LLC
Active, not recruiting

Implantable Cardiac Monitors in High-Risk Post-Infarction Patients With Cardiac Autonomic Dysfunction

Conditions:   Myocardial Infarction;   Autonomic Nervous System Diseases
Intervention:   Device: Medtronic Reveal LINQ implantable cardiac monitor
Sponsors:   Klinikum der Universitaet Muenchen;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK);   Medtronic Bakken Research Center
Recruiting

Brilinta Clinical Experience Investigation

Condition:   Acute Coronary Syndrome, Old Myocardial Infarction
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI

Condition:   Acute Myocardial Infarction
Interventions:   Drug: LCZ696 (sacubitril/valsartan);   Drug: Ramipril;   Drug: Placebo of LCZ696;   Drug: Placebo of ramipril;   Drug: Valsartan;   Drug: Placebo of valsartan
Sponsor:   Novartis Pharmaceuticals
Recruiting

Prolonged Enoxaparin in Primary Percutaneous Coronary Intervention

Condition:   Myocardial Infarction
Intervention:   Drug: Enoxaparin
Sponsors:   Sheffield Teaching Hospitals NHS Foundation Trust;   Medical Research Council
Recruiting

Quantitative Flow Ratio (QFR) Guided Revascularization Strategy for Patients Undergoing Primary Valve Surgery With Comorbid Coronary Artery Disease

Conditions:   Primary Valvular Heart Disease With Comorbid Coronary Artery Disease;   Planned to Undergo Elective On-pump Valve Surgery Due to Primary Mitral and/or Aortic Valvular Heart Disease
Interventions:   Device: QFR-guided strategy;   Other: CAG-guided strategy
Sponsors:   Ruijin Hospital;   Med-X Research Institute, Shanghai Jiao Tong University
Recruiting

French Observatory Syndromes Tako-Tsubo

Conditions:   Myocardial Necrosis;   Tako Tsubo Syndromes
Intervention:  
Sponsor:   French Cardiology Society
Completed

BedMed-Frail: Does the Potential Benefit of Bedtime Antihypertensive Prescribing Extend to Frail Populations?

Conditions:   Hypertension;   Dementia
Intervention:   Other: Bedtime administration of the participant's pre-existing antihypertensive medications
Sponsors:   University of Alberta;   Alberta Innovates Health Solutions;   Canadian Institutes of Health Research (CIHR);   EnACt
Not yet recruiting

Major Outcomes With Personalized Dialysate TEMPerature

Conditions:   Kidney Diseases;   End-Stage Kidney Disease;   Hemodialysis
Intervention:   Other: Personalized Dialysate Temperature
Sponsors:   Lawson Health Research Institute;   Population Health Research Institute;   Ottawa Hospital Research Institute;   Dialysis Clinic, Inc.;   Cancer Care Ontario;   Institute for Clinical Evaluative Sciences;   The Kidney Foundation of Canada;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting

Pharmacogenomics of Anti-platelet Intervention-2 (PAPI-2) Study

Conditions:   Cardiovascular Diseases;   Acute Coronary Syndrome
Interventions:   Drug: clopidogrel;   Drug: prasugrel
Sponsors:   University of Maryland, Baltimore;   National Heart, Lung, and Blood Institute (NHLBI)
Terminated

A Study to Assess All-Cause Mortality and Cardiovascular Morbidity in Participants With Chronic Kidney Disease (CKD) on Dialysis and Those Not on Renal Replacement Therapy Receiving Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) or Reference Erythropoietin Stimulating Agents (ESAs)

Condition:   Chronic Renal Anemia
Interventions:   Drug: Darbepoetin Alfa;   Drug: Epoetin Alfa;   Drug: Epoetin Beta;   Drug: methoxy polyethylene glycol-epoetin beta
Sponsor:   Hoffmann-La Roche
Completed

Disrupt CAD III With the Shockwave Coronary IVL System

Conditions:   Coronary Artery Disease;   Myocardial Infarction
Intervention:   Device: Lithotripsy
Sponsor:   Shockwave Medical, Inc.
Recruiting

Higher vs. Lower Dose Heparin for PCI

Conditions:   Cardiovascular Diseases;   Percutaneous Coronary Intervention
Interventions:   Drug: Higher Dose UFH;   Drug: Lower Dose UFH
Sponsor:   Population Health Research Institute
Not yet recruiting

Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The ECLIPSE Trial

Conditions:   Coronary Artery Disease;   Ischemic Heart Disease;   Non ST Segment Elevation Myocardial Infarction
Interventions:   Device: Orbital Atherectomy;   Device: Balloon
Sponsors:   Cardiovascular Systems Inc;   Cardiovascular Research Foundation, New York
Recruiting

Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk

Conditions:   Type 2 Diabetes Mellitus;   Chronic Kidney Diseases
Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: Placebo
Sponsor:   Sanofi
Recruiting

Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease

Condition:   Coronary Artery Disease
Interventions:   Procedure: Computed tomography angiography (cardiac CT);   Procedure: Invasive coronary angiography (ICA)
Sponsor:   Charite University, Berlin, Germany
Recruiting

International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Coronary Artery Disease;   Heart Diseases;   Myocardial Ischemia
Interventions:   Procedure: cardiac catheterization;   Procedure: coronary artery bypass graft surgery;   Procedure: percutaneous coronary intervention;   Behavioral: Lifestyle;   Drug: Medication
Sponsors:   NYU Langone Health;   New York University;   Stanford University;   National Heart, Lung, and Blood Institute (NHLBI);   Albany Stratton VA Medical Center;   Cedars-Sinai Medical Center;   Columbia University;   Duke University;   East Carolina University;   Emory University;   Harvard University;   Massachusetts General Hospital;   Montreal Heart Institute;   University of British Columbia;   University of Missouri, Kansas City;   Vanderbilt University
Active, not recruiting

Metformin And Cardiovascular Effectiveness vs SGLT2 (MACES)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: SGLT2;   Drug: Metformin
Sponsor:   Brigham and Women's Hospital
Active, not recruiting

A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Completed

CardiAMP™ Heart Failure Trial

Condition:   Heart Failure
Interventions:   Biological: Autologous cell therapy;   Other: Sham
Sponsor:   BioCardia, Inc.
Recruiting

Ticagrelor Compared to Clopidogrel in Acute Coronary Syndromes

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Ticagrelor 90mg;   Drug: Clopidogrel 75mg;   Drug: acetylsalicylic acid (ASA) 81mg
Sponsors:   McGill University Health Center;   Canadian Institutes of Health Research (CIHR)
Recruiting

Genetic Factors in Atherosclerosis

Condition:   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Completed

Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD

Condition:   Coronary Artery Disease
Interventions:   Drug: High dose potent statin;   Drug: ACE-I (lisinopril) or ARB (losartan);   Drug: Aspirin;   Behavioral: Lifestyle Counseling;   Behavioral: Quality of Life Questionnaires
Sponsors:   University of Florida;   United States Department of Defense
Recruiting

Effectiveness of a Proactive Cardiovascular Primary Prevention Strategy, With or Without the Use of Coronary Calcium Screening, in Preventing Future Major Adverse Cardiac Events

Condition:   Cardiovascular Primary Prevention Strategy
Interventions:   Combination Product: Coronary Artery Calcium Screening and Statin Treatment;   Other: Standard Treatment
Sponsor:   Intermountain Health Care, Inc.
Recruiting

Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Biological: Apolipoprotein A-I [human] (apoA-I);   Other: Placebo
Sponsor:   CSL Behring
Recruiting

PRedictOrs, PHEnotypes and Timing of Obstructive Sleep Apnea in Acute Coronary Syndrome

Conditions:   ST Elevated Myocardial Infarction;   Sleep-Disordered Breathing;   Sleep;   NSTEMI - Non-ST Segment Elevation MI
Intervention:   Diagnostic Test: Polygraphy
Sponsor:   Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Recruiting

Cardiac Rehabilitation for TIA Patients

Condition:   TIA (Transient Ischemic Attack)
Intervention:   Behavioral: Comprehensive Cardiac Rehabilitation (CR)
Sponsors:   Lawson Health Research Institute;   Heart and Stroke Foundation of Ontario
Completed

Diuretic Comparison Project

Condition:   Hypertension
Interventions:   Drug: Hydrochlorothiazide (HCTZ);   Drug: Chlorthalidone
Sponsor:   VA Office of Research and Development
Recruiting

Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity

Conditions:   Overweight;   Obesity
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Active, not recruiting

A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo
Sponsor:   Novo Nordisk A/S
Recruiting

The Heartflow Coronary Disease Progression Evaluation Study

Condition:   Coronary Artery Disease
Intervention:   Diagnostic Test: Coronary computed tomography angiography
Sponsor:   Erasmus Medical Center
Recruiting

Providing Patient Information and CT Examination Results

Conditions:   Chest Pain;   Nonmalignant Condition
Intervention:   Other: Extended information
Sponsor:   Haukeland University Hospital
Active, not recruiting

Cardiac Magnetic Resonance Imaging Strategy for the Management of Patients With Acute Chest Pain and Detectable to Elevated Troponin

Conditions:   Acute Coronary Syndrome;   Chest Pain
Interventions:   Procedure: Cardiac MRI;   Other: ACC/AHA Guideline adherent care
Sponsors:   Wake Forest University Health Sciences;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Prognosis of Patients With Acute Coronary Syndrome Complicated With Renal Insufficiency(PACS-RI)

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   Henan Institute of Cardiovascular Epidemiology
Recruiting

Hepatitis C Treatment and Atherosclerosis

Conditions:   Chronic Hepatitis C;   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Metabolic Causes of Thrombosis in Type 2 Diabetes Mellitus

Condition:   Type 2 Diabetes
Interventions:   Procedure: euinsulinemic euglycemic glucose clamp;   Procedure: euinsulinemic hyperglycemic glucose clamp;   Procedure: Hyperinsulinemic euglycemic glucose clamp;   Procedure: Hyperinsulinemic hyperglycemic glucose clamp
Sponsors:   University of Maryland, Baltimore;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Condition:   Hypertension
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

Impact of Early Diagnosis and Treatment of OSA on Hospital Readmission in Hospitalized Cardiac Patients

Conditions:   OSA;   Heart Failure;   Myocardial Infarction;   Arrhythmia, Cardiac
Intervention:   Device: Continuous Positive Airway Pressure
Sponsor:   Kaiser Permanente
Suspended

Internet-based Cognitive Behavioural Therapy for Cardiac Patients

Conditions:   Depression;   Cardiovascular Diseases
Intervention:   Behavioral: internet-based cognitive behavioural therapy
Sponsor:   University of British Columbia
Not yet recruiting

Minor Troponin Elevations in Patients With Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Myocardial Ischemia
Intervention:   Diagnostic Test: No intervention
Sponsor:   University of Turku
Active, not recruiting

Pre-hospital ECG in Acute Coronary Syndromes

Conditions:   Acute Coronary Syndrome;   STEMI;   Non STEMI
Intervention:   Other: No interventions
Sponsors:   Kingston University;   Swansea University;   University of Leeds;   London Ambulance Service;   West Midlands Ambulance Service NHS Foundation Trust;   South West Ambulance Service NHS Foundation Trust
Recruiting

Clopidogrel Pharmacogenetics (PGX) Bench to Bedside

Condition:   Metabolism of Clopidogrel
Interventions:   Drug: Clopidogrel;   Drug: Omeprazole/Clopidogrel
Sponsors:   University of Maryland, Baltimore;   Food and Drug Administration (FDA);   National Cancer Institute (NCI);   National Institute of General Medical Sciences (NIGMS);   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Observational Trial of Cardiotoxicity in Patients Undergoing Chemotherapy.

Conditions:   Cardiotoxicity;   Heart Failure;   Dilated Cardiomyopathy
Interventions:   Diagnostic Test: Echocardiography with speckle tracking analysis.;   Diagnostic Test: 48-hour ECG monitoring.;   Diagnostic Test: Blood samples analysis.
Sponsor:   Moscow State University of Medicine and Dentistry
Recruiting

A Randomized Comparison of CLOpidogrel Monotherapy Versus Extended Dual-antiplatelet Therapy Beyond 12 Months After Implantation of Drug-eluting StEnts in High-risk Lesions or Patients; A-CLOSE Trial

Conditions:   Coronary Artery Disease;   DES
Interventions:   Drug: Clopidogrel mono-therapy;   Drug: Dual-antiplatelet therapy
Sponsor:   Yonsei University
Recruiting

Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID)-2.0

Condition:   Hypertension
Intervention:  
Sponsors:   National Human Genome Research Institute (NHGRI);   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Angiotensin-(1-7) in Peripheral Arterial Disease

Condition:   Peripheral Arterial Disease
Interventions:   Drug: Angiotensin 1-7;   Drug: Saline
Sponsor:   Milton S. Hershey Medical Center
Recruiting

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Clinical Efficacy of Telmisartan in Reducing Cardiac Remodeling Among Obese Patients With Hypertension

Condition:   Hypertension
Interventions:   Drug: telmisartan;   Drug: amlodipine
Sponsor:   First Affiliated Hospital Xi'an Jiaotong University
Recruiting

Early Psychological Intervention to Prevent Cardiovascular Event-Induced PTSD (REACH Sub-study)

Conditions:   Acute Coronary Syndrome;   TIA;   Stroke;   Cardiac Arrest;   PTSD
Intervention:   Behavioral: Written Exposure Therapy
Sponsors:   Columbia University;   National Center for PTSD
Active, not recruiting

Study of the Relationship Between Body Composition, Insulin Resistance and HDL Levels

Conditions:   Obesity;   Insulin Resistance
Intervention:   Drug: Heparin
Sponsors:   University of California, Davis;   Dialysis Clinic, Inc.
Terminated

Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome

Condition:   Antiphospholipid Syndrome
Intervention:  
Sponsor:   Duke University
Recruiting

Atherosclerosis in Rheumatoid Arthritis and Lupus: Restoring Cholesterol Balance

Condition:   Rheumatoid Arthritis
Intervention:  
Sponsors:   Winthrop University Hospital;   Arthritis Foundation
Recruiting

Evaluation of the Pharmacokinetics, Safety and Effects of NutriterraTM in Healthy Adults

Condition:   Healthy
Interventions:   Dietary Supplement: NutriterraTM;   Dietary Supplement: Placebo
Sponsors:   Nuseed Americas Inc.;   Nutrasource Diagnostics Inc.
Active, not recruiting

Efficacy and Safety of Implantable Cardioverter-Defibrillator (ICD) Implantation in the Elderly

Conditions:   Cardiomyopathy;   Coronary Artery Disease;   Congestive Heart Failure;   Myocardial Infarction
Interventions:   Device: Implantable Cardioverter Defibrillator;   Other: Optimal Medical Therapy
Sponsor:   VA Office of Research and Development
Recruiting

EXCEL Clinical Trial

Conditions:   Chronic Coronary Occlusion;   Unprotected Left Main Coronary Artery Disease;   Stent Thrombosis;   Vascular Disease;   Myocardial Ischemia;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Artery Disease;   Coronary Restenosis
Interventions:   Device: Percutaneous Coronary Intervention;   Procedure: CABG
Sponsor:   Abbott Medical Devices
Completed

Unruptured Intracranial Aneurysm Aspirin Trial (UIAAT).

Conditions:   Intracranial Aneurysm;   Inflammation
Intervention:   Drug: Aspirin
Sponsor:   University Hospital Southampton NHS Foundation Trust
Not yet recruiting

Causes and Natural History of Dyslipidemias

Conditions:   Hypercholesterolemia;   Atherosclerosis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

PIONEER III Trial to Assess Safety and Efficacy of the BuMA Supreme™ Drug Coated Coronary Stent in Patients With Coronary Disease

Condition:   Coronary Artery Disease
Interventions:   Device: BuMA Supreme DES;   Device: Xience or Promus DES
Sponsors:   Sino Medical Sciences Technology Inc.;   Nova Vascular LLC
Active, not recruiting

Clinical Study Comparing Single Long BioMimeTM Morph Coronary Stent System vs. Two Overlapping Xience Family Coronary Stent Systems in the Treatment of Patients With Long de Novo Lesions.

Condition:   Coronary Artery Disease
Interventions:   Device: BioMime™ Morph - Sirolimus Eluting Coronary Stent System;   Device: Xience family Everolimus Coronary Stent Systems
Sponsor:   Meril Life Sciences Pvt. Ltd.
Not yet recruiting

Evaluation of Hemodynamic Parameters Following Transjugular Intrahepatic Portosystemic Shunt (TIPS)

Condition:   Refractory Ascites
Interventions:   Procedure: Study - Transjugular Intrahepatic Portosystemic Shunt (TIPS);   Procedure: Control - Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Sponsors:   Medical College of Wisconsin;   Radiological Society of North America
Not yet recruiting

ISCHEMIA-Chronic Kidney Disease Trial

Conditions:   Cardiovascular Diseases;   Coronary Artery Disease;   Heart Diseases;   Myocardial Ischemia;   Kidney Disease;   End Stage Renal Failure on Dialysis
Interventions:   Procedure: Cardiac Catheterization;   Procedure: Coronary Artery Bypass Graft Surgery;   Procedure: Percutaneous Coronary Intervention;   Behavioral: Lifestyle;   Drug: Medication
Sponsors:   NYU Langone Health;   New York University;   National Heart, Lung, and Blood Institute (NHLBI);   Duke University;   Stanford University;   Columbia University
Active, not recruiting

Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation

Condition:   Coronary Artery Disease
Interventions:   Device: iFR;   Device: FFR
Sponsor:   Imperial College London
Active, not recruiting

Evolocumab in Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Evolocumab;   Drug: Placebo
Sponsors:   Johns Hopkins University;   Washington University School of Medicine
Recruiting

The Value of CT-FFR Compared to CCTA or CCTA and Stress MPI in Low to Intermediate Risk ED Patients With Toshiba CT-FFR

Conditions:   Coronary Artery Disease;   Chest Pain;   Acute Coronary Syndrome;   Acute Myocardial Infarction
Intervention:   Device: Toshiba CT-FFR
Sponsors:   Northwell Health;   Toshiba America Medical Systems, Inc.
Enrolling by invitation

Effect of Simvastatin Withdrawal on Ocular Endothelial Function

Condition:   Healthy
Interventions:   Device: Dynamic Vessel Analyzer (DVA);   Device: Laser Doppler Velocimetry (LDV);   Drug: Simvastatin;   Other: Placebo
Sponsor:   Medical University of Vienna
Not yet recruiting

Investigating Idiopathic Pulmonary Fibrosis in Greece (INDULGE IPF)

Condition:   Idiopathic Pulmonary Fibrosis
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Management of Antiplatelet Regimen During Surgical Procedures

Conditions:   Cardiac Surgery;   Surgery;   Percutaneous Coronary Intervention;   Surgery--Complications
Intervention:  
Sponsors:   University of Texas Southwestern Medical Center;   Chiesi Farmaceutici S.p.A.
Recruiting

Effects of Empagliflozin on Diuresis and Renal Function in Patients With Acute Decompensated Heart Failure

Condition:   Acute Decompensated Heart Failure
Interventions:   Drug: Empagliflozin 25 mg;   Drug: Placebo
Sponsors:   Christian Schulze;   Boehringer Ingelheim;   Zentrum für Klinische Studien Jena
Not yet recruiting

The Norwegian Tenecteplase Stroke Trial 2

Conditions:   Stroke, Acute;   Cerebrovascular Disorders;   Ischemic Stroke
Interventions:   Drug: Tenecteplase;   Drug: Alteplase
Sponsor:   Haukeland University Hospital
Not yet recruiting

Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery

Conditions:   Acute Kidney Injury;   Post-Operative Delirium;   Icu Delirium;   Acute Renal Failure;   Delirium
Interventions:   Drug: atorvastatin;   Drug: placebo
Sponsor:   Vanderbilt University Medical Center
Completed

Coronary Artery Disease Management Using Multislice Computed Tomography and Magnetic Resonance Imaging

Condition:   Coronary Artery Disease
Interventions:   Procedure: CT/MR;   Procedure: Catheterization
Sponsors:   Charite University, Berlin, Germany;   University Hospital Muenster;   Charite University, Berlin, Eva Schönenberger, MD;   University of Freiburg
Completed

EUROASPIRE V Survey on Cardiovascular Disease Prevention and Diabetes

Conditions:   Cardiovascular Diseases;   Coronary Heart Disease
Intervention:   Other: There is no intervention
Sponsors:   Imperial College London;   European Society of Cardiology
Completed

Elixir Medical Evaluation of the DESolve® Novolimus Eluting Bioresorbable Coronary Scaffold System - Cx Registry

Condition:   Coronary Artery Disease
Intervention:   Device: DESolve Cx drug eluting coronary scaffold system
Sponsor:   Elixir Medical Corporation
Active, not recruiting

Comparison of Pd/Pa Versus FFR in Intermediate Coronary Stenoses

Conditions:   Coronary Artery Disease;   Coronary Artery Stenoses
Interventions:   Diagnostic Test: measurement of FFR;   Diagnostic Test: measurement of Pd/Pa
Sponsors:   Leipzig Heart Institute GmbH;   Heart Center Leipzig - University Hospital
Not yet recruiting

Study to Learn More About the Benefits and Side-effects of Drugs Rivaroxaban and Apixaban Compared to the Drug Warfarin for Stroke Prevention in Patients With Rapid and Irregular Heartbeat Which is Not Due to a Heart-valve Fault (Non-valvular Atrial Fibrillation) in the UK Routine Clinical Practice

Condition:   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Apixaban (Eliquis);   Drug: Warfarin
Sponsors:   Bayer;   Janssen, LP
Active, not recruiting

Genotyping GUided Antiplatelet theRapy in pAtieNts Treated With Drug Eluting stEnts (GUARANTEE)

Conditions:   Angina, Stable;   Acute Coronary Syndrome;   Drug-Eluting Stents;   Genotype
Intervention:   Genetic: CYP2C19 genotype testing
Sponsor:   Beijing Anzhen Hospital
Recruiting

Effect of Efpeglenatide on Cardiovascular Outcomes

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Efpeglenatide (SAR439977);   Drug: Placebo
Sponsor:   Sanofi
Active, not recruiting

Safety and Effectiveness of Agent Paclitaxel-Coated PTCA Balloon Catheter. (AGENT Japan SV)

Condition:   Coronary Artery Disease
Interventions:   Device: Device: Paclitaxel-Coated PTCA Balloon Catheter;   Device: SeQuent Please Drug Eluting Balloon Catheter with Paclitaxel
Sponsor:   Boston Scientific Corporation
Not yet recruiting

BeSingCardioRehab: CR in Belgium Versus Singapore

Condition:   Ischemic Heart Disease
Intervention:   Other: Cardiac Rehabilitation
Sponsors:   Hasselt University;   Jessa Hospital
Recruiting

Naloxegol US PMR CV Safety.

Condition:   Opioid Induced Constipation
Interventions:   Drug: naloxegol;   Drug: non-PAMORA
Sponsor:   AstraZeneca
Recruiting

INAS-FOCUS (International Active Surveillance Study - Folate in Oral Contraceptives Utilization Study)

Condition:   Contraception
Intervention:  
Sponsors:   Center for Epidemiology and Health Research, Germany;   Bayer
Active, not recruiting

Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia

Condition:   Eligible Men or Women Considered High Risk for Atherosclerotic Cardiovascular Disease (CVD)
Interventions:   Drug: Epanova® (omega-3 carboxylic acids);   Drug: corn oil control
Sponsors:   AstraZeneca;   The Cleveland Clinic;   Quintiles, Inc.
Active, not recruiting

Clinical Evaluation of a Modular Extracorporeal Circulation Circuit

Conditions:   Coronary Artery Disease;   Aortic Valve Disease;   Mitral Valve Disease;   Aortic Aneurysm
Intervention:   Device: Modular Cardiopulmonary Bypass Circuit
Sponsor:   AHEPA University Hospital
Recruiting

Motion and IntraCoronary Ecg Ischemia Development Study (MICE)

Condition:   Ischaemic Heart Disease
Intervention:   Procedure: Percutaneous coronary intervention with FFR measurement and intracoronary ECG registration
Sponsor:   University National Heart Hospital
Recruiting

Blinded Randomized Trial of Anticoagulation to Prevent Ischemic Stroke and Neurocognitive Impairment in AF

Condition:   ATRIAL FIBRILLATION
Interventions:   Drug: Rivaroxaban;   Other: standard of care
Sponsors:   Montreal Heart Institute;   Canadian Stroke Prevention Intervention Network;   The Montreal Health Innovations Coordinating Center (MHICC);   Bayer Healthcare Pharmaceuticals, Inc./Bayer Schering Pharma;   Montreal Heart Institute Foundation
Recruiting

Comparative Effectiveness of Empagliflozin in the US

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Empagliflozin;   Drug: DPP-4 inhibitor
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting

A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men ( TRAVERSE )

Conditions:   Hypogonadism;   Cardiovascular Diseases
Interventions:   Drug: Testosterone;   Drug: Placebo
Sponsors:   AbbVie;   Acerus Pharmaceuticals Corporation;   Allergan Sales, LLC;   Endo Pharmaceuticals;   Upsher-Smith Laboratories
Recruiting

Ticagrelor Versus Clopidogrel in Carotid Artery Stenting

Condition:   Carotid Artery Stenosis
Interventions:   Drug: Ticagrelor;   Drug: Clopidogrel;   Drug: Aspirin
Sponsor:   University Hospital, Basel, Switzerland
Recruiting

ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair.

Conditions:   Abdominal Aortic Aneurysm;   Surgery;   Arterial Disease
Intervention:   Drug: ACT guided heparinization
Sponsors:   Westfriesgasthuis;   ZonMw: The Netherlands Organisation for Health Research and Development;   VU University Medical Center;   AIDS Malignancy Consortium
Not yet recruiting

NOACs for Stroke Prevention in Patients With Atrial Fibrillation and Previous ICH

Conditions:   Atrial Fibrillation;   Intracerebral Hemorrhage
Interventions:   Drug: NOAC;   Drug: Acetylsalicylic Acid
Sponsor:   Population Health Research Institute
Active, not recruiting

French Observatory Evaluating the Use of Intracoronary Prosthesis ABSORB BVS

Condition:   Intracoronary Angioplasty
Intervention:  
Sponsor:   French Cardiology Society
Active, not recruiting

Cardiac Magnetic Resonance for Asymptomatic Type 2 Diabetics With Cardiovascular High Risk (CATCH) - Pilot Study

Conditions:   Diabetes Mellitus, Type 2;   Coronary Artery Disease
Intervention:   Diagnostic Test: Cardiac Magnetic Resonance
Sponsors:   The University of Hong Kong;   Radiological Society of North America
Completed

Efficacy and Safety of Selonsertib in Participants With Moderate to Advanced Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: SEL;   Drug: Placebo
Sponsor:   Gilead Sciences
Recruiting

Correlation of Artherosclerotic Plaque Volume and Intima Media Thickness With Soluble P-selectin

Conditions:   Cardiovascular Risk Factors;   Coronary Artery Disease;   Cerebrovascular Disease;   Peripheral Artery Disease
Intervention:  
Sponsor:   Medical University Innsbruck
Active, not recruiting

EVAS2 IDE Prospective, Multicenter, Single Arm Safety and Effectiveness Confirmatory Study

Condition:   Abdominal Aortic Aneurysm Without Rupture
Intervention:   Device: Nellix® System
Sponsor:   Endologix
Recruiting

Treatment of Heart Failure and Associated Functional Mitral Valve Regurgitation

Condition:   Mitral Valve Regurgitation
Intervention:   Device: ARTO System
Sponsor:   Mvrx, Inc.
Recruiting

Multicentre Study of MITRACLIP® Transcatheter Mitral Valve Repair in Patients With Severe Primary Mitral Regurgitation Eligible for High-risk Surgery

Condition:   Mitral Regurgitation
Interventions:   Device: percutaneous mitral valve repair with MITRACLIP NT;   Procedure: cardiac surgery
Sponsors:   Nantes University Hospital;   Ministère de la Santé;   Abbott
Recruiting

Study of Transcatheter Tricuspid Annular Repair

Condition:   Tricuspid Regurgitation
Interventions:   Device: MIA, Minimally Invasive Annuloplasty Device - Surgical;   Device: MIA, Minimally Invasive Annuloplasty Device - Percutaneous
Sponsor:   Micro Interventional Devices
Recruiting

Assessment of Patients With suspeCted Coronary Artery Disease by Coronary calciUm fiRst strATegy vErsus Usual Care Approach.

Condition:   Coronary Artery Disease
Interventions:   Diagnostic Test: PET Stress Test;   Other: Non-PET Medical Management
Sponsor:   Intermountain Health Care, Inc.
Not yet recruiting

Aortic Replacement Using Individualised Regenerative Allografts - ARISE (the "Surveillance")

Condition:   Heart Valve Disease
Intervention:   Other: Decellularized human heart valves
Sponsors:   corlife;   Hannover Medical School;   Leiden University Medical Center;   Azienda Ospedaliera di Padova;   Hospital Clinic of Barcelona;   Royal Brompton & Harefield NHS Foundation Trust;   Universitaire Ziekenhuizen Leuven;   Heinrich-Heine University, Duesseldorf;   Vienna General Hospital
Completed

MBCT Delivered Via Group Videoconferencing for ACS Patients With Elevated Depression Symptoms

Conditions:   Acute Coronary Syndrome;   Depression;   Myocardial Infarction;   Unstable Angina;   STEMI;   NSTEMI - Non-ST Segment Elevation MI
Interventions:   Other: Focus Group;   Other: Individual Interview
Sponsors:   Massachusetts General Hospital;   National Center for Complementary and Integrative Health (NCCIH)
Recruiting

Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery

Condition:   Atrial Fibrillation
Interventions:   Drug: Amiodarone;   Drug: Minocycline
Sponsor:   Baystate Medical Center
Not yet recruiting

Diabetes Prevention Program Outcomes Study

Conditions:   Diabetes Mellitus;   Cancer;   CVD
Interventions:   Behavioral: DPPOS Group Lifestyle;   Drug: Metformin;   Behavioral: DPPOS Boost Lifestyle;   Behavioral: Intensive Lifestyle Group Session
Sponsors:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute on Aging (NIA);   National Institute on Minority Health and Health Disparities (NIMHD);   National Heart, Lung, and Blood Institute (NHLBI);   National Cancer Institute (NCI);   National Eye Institute (NEI);   National Center for Research Resources (NCRR);   Office of Research on Women's Health (ORWH);   Centers for Disease Control and Prevention;   American Diabetes Association;   Indian Health Service;   General Clinical Research Program;   US Department of Veterans Affairs
Active, not recruiting

TactiSense IDE Trial of TactiCath SE for Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Intervention:   Device: TactiCath SE
Sponsor:   Abbott Medical Devices
Active, not recruiting

Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

Condition:   CAD
Interventions:   Device: MRI scan x 1- Healthy volunteer;   Device: MRI scan x 2- Healthy volunteer;   Device: MRI scan x 2- cardiac disease patients;   Device: MRI scan x 2- patients with non-cardiac disease
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Diet and Exercise Frailty Intervention in Cardiac Device Patients

Conditions:   Frailty;   Cardiovascular Diseases
Intervention:   Other: Exercise and Nutritional Supplement
Sponsor:   Population Health Research Institute
Not yet recruiting

A Nationwide Observational Study Looking at Effectiveness and Bleeding Complications of NOACs vs. VKA in Non-valvular Atrial Fibrillation Patients.

Condition:   Non-valvular Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Apixaban (Eliquis);   Drug: Dabigatran etexilate (Pradaxa);   Drug: Warfarin (Marevan)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

Effect of Liraglutide on the Metabolic Profile in Patients With Type 2 Diabetes and Cardiovascular Disease

Conditions:   Type 2 Diabetes;   Cardiovascular Diseases
Interventions:   Drug: Liraglutide Pen Injector [Victoza];   Drug: Placebo
Sponsors:   RWTH Aachen University;   Novo Nordisk A/S
Not yet recruiting

FFR vs. icECG in Coronary Bifurcations

Condition:   Coronary Artery Disease
Intervention:   Procedure: Intracoronary ECG
Sponsor:   University National Heart Hospital
Recruiting

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Conditions:   Acute Coronary Syndrome;   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting

Real-life Clinical Outcomes of Direct Oral Anticoagulants (MACACOD)

Conditions:   Atrial Fibrillation;   Recurrent Venous Thromboembolism
Intervention:   Drug: dabigatran, rivaroxaban, apixaban or edoxaban
Sponsors:   Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau;   Daiichi Sankyo, Inc.
Recruiting

Association of PeriOPerative Aspirin-ResisTance and CardioVascular Outcome

Condition:   Vascular Surgery
Intervention:  
Sponsor:   University Hospital Heidelberg
Not yet recruiting

The Value of Screening for HPR in Patients Undergoing Lower Extremity Arterial Endovascular Interventions

Conditions:   Peripheral Artery Disease;   Clopidogrel, Poor Metabolism of;   Peripheral Vascular Disease;   Artery Disease;   Peripheral Arterial Occlusive Disease
Interventions:   Diagnostic Test: Point of care screening for HPR;   Drug: Ticagrelor 90mg
Sponsor:   Kyle Markel
Recruiting

MyoVasc Study on the Development and Progression of Heart Failure

Condition:   Heart Failure
Intervention:  
Sponsor:   Johannes Gutenberg University Mainz
Active, not recruiting

Smarter Care Virginia

Conditions:   Chronic Kidney Diseases;   Eye Diseases;   Cardiac Disease;   Surgery
Intervention:   Behavioral: Multicomponent Physician Performance Peer-Comparison Feedback Intervention
Sponsor:   University of California, Los Angeles
Active, not recruiting

LOwer Maintenance Dose TICagrelor in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention

Conditions:   Antiplatelet Therapy;   Coronary Artery Disease;   Percutaneous Coronary Intervention
Interventions:   Drug: Ticagrelor 90mg;   Drug: Ticagrelor 90mg/60mg;   Drug: Clopidogrel 75mg
Sponsor:   Beijing Anzhen Hospital
Not yet recruiting

HighLife™ Transcatheter Mitral Valve Replacement System Study

Conditions:   Mitral Valve Regurgitation;   Mitral Valve Insufficiency
Intervention:   Device: Transcatheter Mitral Valve Replacement
Sponsors:   HighLife SAS;   Meditrial Europe Ltd.;   Action, France
Active, not recruiting

Comparison of Minimal Versus Conventional Extracorporeal Circulation in Coronary Surgery

Condition:   Coronary Artery Bypass
Interventions:   Procedure: Coronary artery bypass grafting with the use of minimal invasive extracorporeal circulation;   Procedure: Coronary artery bypass grafting under conventional extracorporeal circulation
Sponsor:   AHEPA University Hospital
Active, not recruiting

Effect of Anesthesia Technique on Early Outcome in Diabetic Patients Undergoing Lower Extremity Amputation

Condition:   Diabetic Foot
Interventions:   Drug: General anesthesia;   Drug: Peripheral nerve block
Sponsor:   Yonsei University
Not yet recruiting

Study to Develop a Prediction Model to Understand the Effect of Low-dose Aspirin on Cancer That Develops in the Colon and/or the Rectum, Diseases That Affects the Heart or Blood Vessels and Safety Outcomes in European Countries. The Study is Also Called PEACOS Model EU

Conditions:   Colorectal Cancer;   Cardiovascular Disease;   Bleeding
Intervention:   Drug: Acetylsalicylic Acid (Aspirin, BAYE4465)
Sponsor:   Bayer
Active, not recruiting

Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study

Condition:   Bicuspid Aortic Valve
Intervention:   Device: Medtronic TAVR Systems
Sponsor:   Medtronic Cardiovascular
Recruiting

Comparison of Aortic Stenosis Subtypes After Balloon Aortic Valvuloplasty

Condition:   Aortic Valve Stenosis
Interventions:   Procedure: BAV;   Procedure: BAV + TAVR
Sponsor:   Heinrich-Heine University, Duesseldorf
Active, not recruiting

Primary Aldosteronism: Prospective Screening Registry in China

Condition:   Primary Aldosteronism
Intervention:   Other: NO Intervention
Sponsor:   Shanghai Jiao Tong University School of Medicine
Not yet recruiting

Cardiology Biobank Registry

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   Emory University
Recruiting

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Efficacy and Safety of AMG0001 in Subjects With Critical Limb Ischemia

Condition:   Critical Limb Ischemia
Interventions:   Biological: HGF Plasmid (AMG0001);   Biological: Matching Placebo
Sponsor:   AnGes USA, Inc.
Terminated

European Active Surveillance Study Comparing Regimens of Administration in Combined Hormonal Contraception

Condition:   Contraception
Intervention:  
Sponsors:   Center for Epidemiology and Health Research, Germany;   Gedeon Richter Plc.
Terminated

Registration of Idarucizumab for Patients With IntraCranial Hemorrhage

Condition:   Intracranial Hemorrhage
Interventions:   Drug: Dabigatran Etexilate Oral Capsule [Pradaxa];   Drug: Idarucizumab 2.5 GM/50 ML Intravenous Solution [PRAXBIND];   Drug: Vitamin K antagonist
Sponsor:   University Hospital, Essen
Not yet recruiting

Role of On-site CT-derived FFR in the Management of Suspect CAD Patients

Condition:   Coronary Artery Disease
Intervention:   Diagnostic Test: CT-FFR
Sponsors:   Chinese PLA General Hospital;   Anzhen Hospital, Capital Medical University, Beijing;   First Affiliated Hospital of Xinjiang Medical University;   Qilu Hospital of Shandong University;   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Tongji Hospital
Recruiting

Rest Ventilatory Parameters Predict Morbidity and Mortality in Thoracic Surgery

Conditions:   Pulmonary Complication;   Cardiovascular Complication
Intervention:   Procedure: Thoracic surgery
Sponsor:   St. Anne's University Hospital Brno, Czech Republic
Recruiting

Metabolomic Analysis of Systemic Sclerosis

Conditions:   Scleroderma (Limited and Diffuse);   Undifferentiated Connective Tissue Disease;   Raynaud Disease;   Vascular Disease;   Healthy Control Subjects
Intervention:   Procedure: - Skin biopsy - Urine sample - Blood sample
Sponsor:   University Hospital, Strasbourg, France
Recruiting

Different Antiplatelet Therapy Strategy After Coronary Artery Bypass Graft Surgery

Conditions:   Coronary Artery Bypass;   Antiplatelet Agents
Interventions:   Drug: Aspirin;   Drug: Ticagrelor
Sponsor:   Ruijin Hospital
Completed

HeAlth-data Register sTudies of Risk and Outcomes in Cardiac Surgery

Conditions:   Cardiovascular Diseases;   Kidney Diseases;   Depression;   Diabetes Mellitus
Interventions:   Procedure: Coronary artery bypass surgery;   Procedure: Heart valve surgery
Sponsors:   Ulrik Sartipy, MD, PhD;   Karolinska Institutet
Active, not recruiting

EMPRA (EMPagliflozin and RAs in Kidney Disease)

Conditions:   Diabetic Kidney Disease;   Diabetes Mellitus, Type 2;   Chronic Kidney Disease stage3;   Chronic Kidney Disease stage4
Interventions:   Drug: Empagliflozin 10 MG [Jardiance];   Drug: Placebo Oral Tablet
Sponsors:   Medical University of Vienna;   Attoquant Diagnostics
Completed

Thoraflex™ Hybrid IDE Study

Conditions:   Aortic Aneurysm;   Aortic Dissection;   Aortic Rupture
Intervention:   Device: Thoraflex™ Hybrid Device
Sponsors:   Bolton Medical;   Vascutek Ltd.
Active, not recruiting

Transpacific TAVR Registry

Conditions:   Heart Valve Diseases;   Aortic Valve Insufficiency
Intervention:   Procedure: TAVR
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea
Recruiting

[Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients]

Conditions:   Vasoplegic Syndrome;   Liver Transplant; Complications
Interventions:   Drug: Hydroxocobalamin;   Drug: Methylene Blue
Sponsor:   Mayo Clinic
Not yet recruiting

Frail Status of Elderly Patients After Repair and Anesthesia Guided by the bispectraL Index

Conditions:   Anesthesia, General;   Aged, 70 and Over
Interventions:   Other: Toolbox: Automated group;   Other: Manual group
Sponsor:   Hopital Foch
Suspended

Management and Clinical Outcomes of Patients With Severe Mitral Valve Disease Not Suitable for Surgery

Condition:   Mitral Valve Disease
Intervention:  
Sponsor:   French Cardiology Society
Recruiting

STOP-AUST: The Spot Sign and Tranexamic Acid On Preventing ICH Growth - AUStralasia Trial

Conditions:   Intracerebral Haemorrhage;   Stroke
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsor:   Neuroscience Trials Australia
Active, not recruiting

S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer

Conditions:   Cardiotoxicity;   HER2/Neu Positive;   Metastatic Malignant Neoplasm in the Brain;   Recurrent Breast Carcinoma;   Stage IV Breast Cancer AJCC v6 and v7
Interventions:   Drug: Carvedilol;   Other: Laboratory Biomarker Analysis;   Other: Patient Observation
Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
Recruiting

A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

Study on Safety and Performance of Medtentia Mitral Valve Repair System in Surgical Repair of Mitral Regurgitation

Conditions:   Mitral Regurgitation;   Mitral Insufficiency
Intervention:   Device: Mitral valve repair using the Medtentia Annuloplasty Ring (MAR)
Sponsor:   Medtentia International Ltd Oy
Terminated

Oral Factor XIa Inhibitor for the Prevention of New Ischemic Stroke in Patients Receiving Aspirin and Clopidogrel Following Acute Ischemic Stroke or Transient Ischemic Attack (TIA)

Conditions:   Acute Ischemic Stroke;   Transient Ischemic Attack (TIA)
Interventions:   Drug: BMS-986177;   Other: BMS-986177 Placebo;   Drug: Clopidogrel;   Drug: Aspirin
Sponsors:   Bristol-Myers Squibb;   Janssen, LP
Recruiting

Safety of Terminating the Use of Aspirin After Left Atrial Appendage Closure

Conditions:   Atrial Fibrillation;   Stroke;   Left Atrial Appendage Thrombosis
Intervention:   Drug: Termination of aspirin
Sponsor:   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Recruiting

Efficacy of Subintimal vs Intraluminal Approach for Atherosclerotic Chronic Occlusive Femoropopliteal Arterial Disease

Conditions:   Peripheral Arterial Disease;   Atherosclerosis
Interventions:   Procedure: Intentional intraluminal approach;   Procedure: Intentional subintimal approach
Sponsor:   Korea University Guro Hospital
Recruiting

An Evaluation of a Physiology-guided PCI Optimisation Strategy

Conditions:   Coronary Artery Disease;   Coronary Stenosis
Interventions:   Procedure: P.I.O.S.;   Diagnostic Test: Pre and post-PCI coronary physiology measurements
Sponsor:   NHS National Waiting Times Centre Board
Recruiting

Comparison of Oral Anticoagulants for Extended VEnous Thromboembolism

Condition:   Venous Thromboembolism
Interventions:   Drug: Warfarin;   Drug: Apixaban 2.5 MG;   Drug: Rivaroxaban 10 MG
Sponsors:   Duke University;   Patient-Centered Outcomes Research Institute
Terminated

French Observatory on the Management of Cardiogenic Shock in 2016

Condition:   Shock, Cardiogenic
Intervention:  
Sponsor:   French Cardiology Society
Completed

ExtraCorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock

Condition:   Cardiogenic Shock
Interventions:   Device: Veno-arterial extracorporeal membrane oxygenation (ECMO);   Other: Early conservative therapy according to standard practice
Sponsors:   Na Homolce Hospital;   General University Hospital, Prague;   University Hospital Pilsen
Recruiting

Efficacy Study of Cilostazol and Aspirin on Cerebral Small Vessel Disease

Condition:   Cerebral Small Vessel Disease
Interventions:   Drug: aspirin;   Drug: cilostazol
Sponsors:   Inha University Hospital;   Otsuka Pharmaceutical Development & Commercialization, Inc.
Active, not recruiting

A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunction

Conditions:   Hypertension, Pulmonary;   Ventricular Dysfunction, Left
Interventions:   Drug: Riociguat (Adempas, BAY63-2521);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Renal Stent Placement for the Treatment of Renal Artery Stenosis in Patients With Resistant Hypertension

Conditions:   Renal Artery Stenosis;   Hypertension, Renovascular
Intervention:   Device: iCAST™ Rx Stent System
Sponsor:   Atrium Medical Corporation
Active, not recruiting

In the Management of Coronary Artery Disease, Does Routine Pressure Wire Assessment at the Time of Coronary Angiography Affect Management Strategy, Hospital Costs and Outcomes?

Conditions:   Chest Pain;   Stable Angina;   Acute Coronary Syndrome;   Non ST Segment Elevation Acute Coronary Syndrome
Intervention:   Device: Routine Measurement of FFR
Sponsors:   University Hospital Southampton NHS Foundation Trust;   Liverpool Heart and Chest Hospital NHS Foundation Trust
Active, not recruiting

STOP-MSU: Stopping Haemorrhage With Tranexamic Acid for Hyperacute Onset Presentation Including Mobile Stroke Units

Condition:   Intracerebral Haemorrhage
Interventions:   Drug: Tranexamic Acid;   Drug: Normal saline
Sponsors:   Neuroscience Trials Australia;   The Florey Institute of Neuroscience and Mental Health
Recruiting

Endovascular Treatment Key Technique and Emergency Work Flow Improvement of Acute Ischemic Stroke

Condition:   Intracranial Artery Occlusion With Infarction (Disorder)
Intervention:  
Sponsor:   Beijing Tiantan Hospital
Completed

Anemia Studies in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat in Non-Dialysis Subjects Evaluating Hemoglobin (Hgb) and Quality of Life (ASCEND-NHQ)

Condition:   Anaemia
Interventions:   Drug: Daprodustat (GSK1278863);   Drug: Placebo;   Drug: Iron therapy
Sponsor:   GlaxoSmithKline
Recruiting

Safety and Efficacy of the SurVeil™ Drug-Coated Balloon

Conditions:   Peripheral Arterial Disease;   Peripheral Vascular Disease;   Artery Disease, Peripheral;   Femoropopliteal Artery Occlusion
Interventions:   Device: Surmodics SurVeil DCB;   Device: Medtronic IN.PACT Admiral DCB
Sponsor:   SurModics, Inc.
Recruiting

Nutrition Therapy in Improving Immune System in Patients With Bladder Cancer That Can Be Removed by Surgery

Condition:   Bladder Carcinoma
Interventions:   Other: Laboratory Biomarker Analysis;   Dietary Supplement: Nutritional Intervention;   Other: Placebo;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
Recruiting

A Two-Arm Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Administration of the Fixed-Dose Combination of Pertuzumab and Trastuzumab in Combination With Chemotherapy in Chinese Participants With HER2-Positive Early Breast Cancer

Condition:   HER2-positive Early Breast Cancer
Interventions:   Drug: Pertuzumab IV;   Drug: Trastuzumab IV;   Drug: FDC of Pertuzumab and Trastuzumab SC;   Drug: Doxorubicin;   Drug: Cyclophosphamide;   Drug: Docetaxel;   Procedure: Surgery;   Radiation: Post-Operative Radiotherapy;   Drug: Hormone Therapy
Sponsor:   Hoffmann-La Roche
Not yet recruiting

Personalized Activity Intervention in Rehabilitation After Cardiac Operations (the PACO Trial)

Conditions:   Coronary Artery Disease;   Aortic Valve Stenosis;   Mitral Valve Insufficiency
Interventions:   Behavioral: PACO intervention for CABG patients;   Behavioral: PACO intervention for AVR patients;   Behavioral: PACO intervention for MVR patients
Sponsors:   Kuopio University Hospital;   UKK Institute;   Turku University Hospital
Recruiting

The De-novo Use of Eculizumab in Presensitized Patients Receiving Cardiac Transplantation

Conditions:   Antibody-mediated Rejection;   Hyperacute Rejection of Cardiac Transplant;   Left Ventricular Dysfunction;   Cardiac Allograft Vasculopathy;   Heart Graft Dysfunction
Intervention:   Drug: Eculizumab
Sponsors:   Cedars-Sinai Medical Center;   Alexion Pharmaceuticals
Active, not recruiting

Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics

Conditions:   Osteomyelitis;   Diabetes;   Amputation
Interventions:   Drug: Rifampin;   Drug: Riboflavin Placebo
Sponsor:   VA Office of Research and Development
Recruiting

Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.

Condition:   Acute Kidney Injury
Interventions:   Drug: Nitric Oxide;   Other: Placebo
Sponsors:   Massachusetts General Hospital;   Ichinose, Fumito, M.D., Ph.D., Massachusetts General Hospital;   Kenneth, Shelton, M.D., Massachusetts General Hospital;   Kacmarek, Robert M., Ph.D., Massachusetts General Hospital;   Sundt, Thoralf M., M.D., Massachusetts General Hospital;   Villavicencio-Theoduloz, Mauricio A., M.D., Massachusetts General Hospital;   Thompson, Boyd Taylor, M.D., Massachusetts General Hospital;   Bonventre, Joseph V., M.D., Brigham Women Hospital;   Shann, Kenneth G., Massachusetts General Hospital;   Zapol, Warren M., M.D.;   Marrazzo, Francesco, M.D., Massachusetts General Hospital;   Spina, Stefano, M.D., Massachusetts General Hospital;   Zadek, Francesco, M.D., Massachusetts General Hospital;   Rezoagli, Emanuele, M.D., Massachusetts General Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Program Using a Mobile Application Versus Telephone Advice on Patients at Risk of Coronary Heart Disease : a Pilot RCT

Condition:   Coronary Heart Disease
Intervention:   Device: App support Programme (ASP) group
Sponsors:   The Hong Kong Polytechnic University;   Tuen Mun Hospital
Recruiting

OCT vs IVUS vs QCA to Guide Moderate-to-severe Calcified Lesion Stent Implantation

Conditions:   Optical Coherence Tomography;   Intravascular Ultrasound;   Angiography
Interventions:   Device: OCT guidance;   Device: IVUS guidance;   Device: QCA
Sponsor:   Shanghai MicroPort Medical (Group) Co., Ltd.
Not yet recruiting

Impact of Self-monitoring of Blood Pressure and Self-titration of Medication in the Control of Hypertension (ADAMPA)

Conditions:   Hypertension;   Adjustment;   Adherence, Medication
Intervention:   Other: Self-monitoring/Self-titration
Sponsors:   Fundación para la Investigación del Hospital Clínico de Valencia;   Spanish Clinical Research Network - CAIBER;   Carlos III Health Institute
Active, not recruiting

Safety and Efficacy Study of Lotus Valve for Transcatheter Aortic Valve Replacement (REPRISE Japan)

Condition:   Aortic Stenosis
Intervention:   Device: Lotus Valve System
Sponsor:   Boston Scientific Corporation
Active, not recruiting

EVOlocumab for Early Reduction of LDL-cholesterol Levels in Patients With Acute Coronary Syndromes (EVOPACS)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Evolocumab 140 mg/mL;   Drug: Placebo
Sponsors:   University Hospital Inselspital, Berne;   Amgen;   University of Bern
Completed

Pathophysiology of Acute Pain in Patients With Sickle Cell Disease

Condition:   Sickle Cell Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Carotid Plaque Imaging in Acute Stroke

Conditions:   Stroke;   Ischemic Attack, Transient
Intervention:  
Sponsors:   Ludwig-Maximilians - University of Munich;   Technische Universität München
Active, not recruiting

Stem Cell Transplantation and T-Cell Add-Back to Treat Bone Marrow Malignances

Conditions:   Immunosuppression;   Leukemia
Intervention:   Device: SOLEX 300i Stem Cell Selection
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed