Heart Attack

Clinical Trial Finder

Many patients with heart disease are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Functional Assessment in Elderly MI Patients With Multivessel Disease

Condition:   Myocardial Infarction
Interventions:   Other: Culprit-only revascularization;   Other: Complete functionally-guided revascularization
Sponsor:   Consorzio Futuro in Ricerca
Not yet recruiting

The Effect of Education and Telephone Follow-up Intervention

Condition:   Myocardial Infarction
Intervention:   Other: Education and telephone follow-up intervention
Sponsor:   Akdeniz University
Completed

Multicentre REtrospective StuDy of Treatment and OUtComes in STEMI Patients in Fujian Province

Condition:   ST-segment Elevation Myocardial Infarction
Intervention:   Other: treatment and outcome
Sponsors:   Yan-song Guo;   Longyan City First Hospital;   The Affiliated Hospital of Putian University;   The Second Affiliated Hospital of Fujian Medical University;   The MinDong Hospital of Ningde City
Recruiting

Myocardial Infarction, COmbined-device, Recovery Enhancement Study

Conditions:   Acute Myocardial Infarction;   Coronary Artery Disease;   Acute Coronary Syndrome;   Myocardial Infarction
Intervention:   Device: Corrie Digital Health platform
Sponsors:   Johns Hopkins University;   Apple Inc.;   iHealth
Recruiting

Treatment of Post-STEMI Left Ventricular Thrombus With Optimized Anticoagulant

Conditions:   ST Segment Elevation Myocardial Infarction;   Left Ventricular Thrombus
Interventions:   Drug: Rivaroxaban;   Drug: Vitamin K Antagonist
Sponsor:   RenJi Hospital
Not yet recruiting

IVUS-guided DK Crush Stenting Technique for Patients With Complex Bifurcation Lesions

Condition:   Coronary Artery Disease
Intervention:   Procedure: Stenting
Sponsor:   Nanjing First Hospital, Nanjing Medical University
Not yet recruiting

Registry Study of Cardiac Multi-modality Imaging Overview for Patients With STEMI

Conditions:   STEMI;   Reperfusion Injury, Myocardial;   Arrhythmias, Cardiac;   Heart Failure
Intervention:   Device: PCI
Sponsor:   RenJi Hospital
Recruiting

Method of Clopidogrel Pre-treatment Undergoing Conventional Coronary Angiogram in Angina Patients

Condition:   Angina, Stable
Interventions:   Drug: clopidogrel 75mg;   Drug: Clopidogrel 300 mg;   Drug: clopidogrel 600mg
Sponsor:   Korea University Anam Hospital
Completed

Aspirin Withdrawal and Clinical Outcome in Patients With Moderate to High Cardiovascular Risk But Without Cardiovascular Disease

Condition:   Healthy Participants With Moderate and High Cardiovascular Risk
Intervention:   Other: Withdrawal of aspirin
Sponsor:   Yonsei University
Not yet recruiting

Short Interval Resveratrol Trial in Cardiovascular Surgery

Conditions:   Diabetes Mellitus, Type 2;   Coronary Artery Disease
Interventions:   Dietary Supplement: Trans-resveratrol;   Dietary Supplement: Placebo
Sponsors:   Maine Medical Center;   American Heart Association
Recruiting

Concordance Between FFR and iFR for the Assessment of Intermediate Lesions in the Left Main Coronary Artery. A Prospective Validation of a Default Value for iFR

Conditions:   Coronary Artery Disease;   Left Main Coronary Artery Stenosis;   Left Main Coronary Artery Disease;   Restenosis, Coronary
Intervention:   Other: Indication of revascularization
Sponsor:   Fundación EPIC
Not yet recruiting

Cerebral Perfusion During Induction of General Anesthesia

Conditions:   Radiography;   Interventional
Intervention:   Procedure: All monitoring
Sponsors:   Assistance Publique - Hôpitaux de Paris;   INSERM UMR-942, Paris, France;   Department of Anesthesiology, Hopital Foch, Suresnes, France.;   LMS Polytechnique and M3DISIM, Inria, Université Paris-Saclay;   Ouctomes Research Consortium, Cleveland Clinic, Ohio, USA
Completed

Antegrade and Retrograde Dissection and Re-entry Approach for CTO

Condition:   Chronic Total Occlusion of Coronary Artery
Intervention:   Device: chronic total occlusion
Sponsor:   Xijing Hospital
Not yet recruiting

The Randomized OPTIMAL-ACT Trial

Conditions:   Coronary Artery Disease;   Ischemic Heart Disease;   Anticoagulant-induced Bleeding;   Coronary Syndrome
Intervention:   Drug: Unfractionated heparin
Sponsor:   Mayo Clinic
Not yet recruiting

The Effect of Simvastatin Combined With Ezetimibe in Patients With Stable Angina and Diabetes

Condition:   Coronary Heart Disease
Interventions:   Drug: Ezetimibe with simvastatin;   Drug: Simvastatin
Sponsor:   Chinese PLA General Hospital
Recruiting

Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial

Conditions:   Intravenous Alteplase Thrombolysis;   Neurological Improving
Intervention:   Drug: ginkgolide
Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University
Recruiting

Low- and Moderate-intensity Statin and Clinical Outcome of Primary Prevention in Individuals Aged >75 Years: the SCOPE-75 RCT Study

Condition:   Healthy Elderly Individuals With High LDL-cholesterol or Risk of Cardiovascular Disease
Interventions:   Drug: Low intensity statin;   Drug: Moderate intensity statin
Sponsor:   Yonsei University
Not yet recruiting

Scoreflex NC - Scoring PTCA Catheter

Conditions:   Coronary Artery Disease;   Coronary Disease;   Myocardial Ischemia;   Heart Diseases;   Arteriosclerosis;   Cardiovascular Diseases
Intervention:   Device: Scoreflex NC Scoring PTCA catheter
Sponsors:   OrbusNeich;   ClinLogix. LLC
Not yet recruiting

Graft Patency of QFR-guided Versus Angio-guided Coronary Artery Bypass Grafting

Conditions:   Coronary Artery Disease;   Ischemic Heart Disease
Interventions:   Procedure: QFR-guided CABG;   Procedure: Angio-guided CABG
Sponsors:   Beijing Anzhen Hospital;   Beijing Municipal Science & Technology Commission
Recruiting

Incentives and Case Management to Improve Cardiac Care: Healthy Lifestyle Program

Condition:   Cardiac Rehabilitation
Interventions:   Behavioral: Incentives;   Behavioral: Case Management
Sponsors:   University of Vermont;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Natural History of GACI With or Without ARHR2 or PXE

Conditions:   Generalized Arterial Calcification in Infancy;   Autosomal Recessive Hypophosphatemic Rickets;   Pseudoxanthoma Elasticum
Intervention:   Other: No intervention
Sponsors:   Westfälische Wilhelms-Universität Münster;   ICON plc
Recruiting

New Ischemic Cerebral Lesions After Endarterectomy vs. Stenting for the Treatment of Symptomatic Carotid Stenosis

Conditions:   Carotid Artery Stenosis;   Carotid Atherosclerosis;   Stroke, Ischemic
Interventions:   Procedure: Carotid Artery Stenting;   Procedure: Endarterectomy carotid artery
Sponsor:   Jagiellonian University
Terminated

Moderato System in Patients With Hypertension

Conditions:   Hypertension, Resistant to Conventional Therapy;   Atrioventricular Block
Interventions:   Device: BackBeat Moderato System;   Device: BackBeat Moderato Sytsem
Sponsors:   BackBeat Medical Inc;   MGH Echo Core Lab;   MLM Medical Labs GmbH;   nabios GmbH
Recruiting

Total Arterial Revascularization (TAR)

Conditions:   Coronary Artery Disease;   Coronary Artery Bypass Grafting
Interventions:   Procedure: Y-Graft;   Procedure: In-Situ
Sponsors:   Meshalkin Research Institute of Pathology of Circulation;   Kemerovo Cardiology Center
Recruiting

The Influence of Gene Polymorphism on Clinical Outcomes in Patients Undergoing PCI

Conditions:   Antiplatelet Therapy;   CYP2C19 Polymorphism
Intervention:   Genetic: CYP2C19
Sponsor:   Beijing Anzhen Hospital
Not yet recruiting

Evaluation of Safety and Effectiveness on Oral Anticoagulants

Condition:   Atrial Fibrillation
Intervention:   Other: Non-Interventional
Sponsors:   Bristol-Myers Squibb;   Pfizer
Active, not recruiting

Oral Factor XIa Inhibitor for the Prevention of New Ischemic Stroke in Patients Receiving Aspirin and Clopidogrel Following Acute Ischemic Stroke or Transient Ischemic Attack (TIA)

Conditions:   Acute Ischemic Stroke;   Transient Ischemic Attack (TIA)
Interventions:   Drug: BMS-986177;   Other: BMS-986177 Placebo;   Drug: Clopidogrel;   Drug: Aspirin
Sponsors:   Bristol-Myers Squibb;   Janssen, LP
Not yet recruiting

ABC-Scores for Reduction of Stroke and Mortality in Atrial Fibrillation - The ABC-AF Study

Condition:   Atrial Fibrillation
Interventions:   Other: ABC score guided therapy;   Other: Standard care
Sponsors:   Uppsala University;   Swedish Foundation for Strategic Research;   Swedish Heart Lung Foundation;   Roche Diagnostics
Recruiting

Treating Heart Failure With hPSC-CMs

Condition:   Heart Failure
Intervention:   Biological: hPSC-CM therapy
Sponsors:   Help Therapeutics;   The First Affiliated Hospital with Nanjing Medical University;   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School;   The First Affiliated Hospital of Dalian Medical University
Recruiting

Risk of Major Adverse Cardiovascular Events for Naldemedine and Other Medications for Opioid Induced Constipation in Adults With Chronic Non-Cancer Pain

Condition:   Opioid-induced Constipation
Interventions:   Drug: Naldemedine;   Drug: Lubiprostone;   Drug: Naloxegol
Sponsor:   Shionogi
Not yet recruiting

Renal Sympathetic Denervation From the Adventitia on Resistant Hypertension(RSDARH)

Condition:   Resistant Hypertension
Intervention:   Device: Radiofrequency ablation instruments
Sponsor:   Henan Institute of Cardiovascular Epidemiology
Recruiting

Stroke Imaging Package Study of Intracranial Atherosclerosis ( SIPS-ICAS )

Conditions:   Acute Ischemic Stroke AIS;   Intracranial Atherosclerosis ICAS
Intervention:   Drug: aggressive medical management
Sponsors:   Wei-Hai Xu;   Peking Union Medical College Hospital;   General Hospital of Chinese Armed Police Forces;   General Hospital of Shenyang Military Region;   Subei People's Hospital of Jiangsu Province;   Fujian Medical University Union Hospital;   Tangshan Gongren Hospital;   Third Affiliated Hospital, Sun Yat-Sen University;   Qingdao Municipal Hospital;   West China Hospital;   Shanghai Tong Ren Hospital;   Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine;   The First Affiliated Hospital of University of South China;   JiNing NO.1 People Hospital;   Tongji Hospital;   The University of HongKong-Shenzhen Hospital;   Beijing Anzhen Hospital;   Beijing Hospital;   Peking University International Hospital;   Beijing Tongren Hospital;   China-Japan Friendship Hospital;   Peking University First Hospital;   Beijing Friendship Hospital;   Beijing Chao Yang Hospital;   Qilu Hospital of Shandong University (Qingdao)
Recruiting

Can Continuous Cardiac Output Monitoring Before General Anesthesia Predict Hypotension After Induction?

Conditions:   Anesthesia, General;   Hypotension;   Cardiac Output
Intervention:  
Sponsor:   National Taiwan University Hospital
Not yet recruiting

Central Venous Pressure (CVP) Changes do Not Predict Preload Unresponsiveness

Condition:   Cardiovascular Shock
Intervention:   Diagnostic Test: preload responsiveness
Sponsor:   Hopital Antoine Beclere
Recruiting

Nutrition Therapy in Improving Immune System in Patients With Bladder Cancer That Can Be Removed by Surgery

Condition:   Bladder Carcinoma
Interventions:   Other: Laboratory Biomarker Analysis;   Dietary Supplement: Nutritional Intervention;   Other: Placebo;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
Not yet recruiting

Delirium Reduction by Volatile Anesthesia in Cardiac Surgery

Condition:   Delirium
Interventions:   Drug: Volatile agent;   Drug: Propofol
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Not yet recruiting

Left Atrial Appendage Ligation Using the Atriclip Device

Condition:   Left Atrial Appendage Ligation
Intervention:   Device: exclusion of the left atrial appendage
Sponsors:   St. Helena Hospital Coon Joint Replacement Institute;   AtriCure, Inc.;   Adventist Heart and Vascular Institute
Completed

Pulsewatch: Smartwatch Monitoring for Atrial Fibrillation After Stroke

Conditions:   Stroke;   Atrial Fibrillation
Interventions:   Device: Testing Devices;   Device: CardioKey device by Biotel
Sponsors:   University of Massachusetts, Worcester;   University of Connecticut;   Northeastern University;   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

INcreasing Statin Prescribing in HIV Behavioral Economics REsearch

Conditions:   HIV;   Cardiovascular Diseases
Interventions:   Behavioral: Knowledge assessment;   Behavioral: Education Intervention;   Behavioral: Provider Feedback
Sponsors:   University of California, Los Angeles;   RAND;   Olive View-UCLA Education & Research Institute
Not yet recruiting

Effect of Exercise on Cardiometabolic Profile in Women With Polycystic Ovary Syndrome

Condition:   Polycystic Ovary Syndrome
Interventions:   Behavioral: Exercise Intervention;   Behavioral: Lifestyle Physical Activity
Sponsors:   Sheffield Hallam University;   Sheffield Teaching Hospitals NHS Foundation Trust
Recruiting

Rapid Use of High-sensitive Cardiac Troponin I for ruling-in and Ruling-out of Acute Myocardial Infarction

Conditions:   Myocardial Infarction;   Chest Pain
Intervention:  
Sponsors:   Aarhus University Hospital;   Randers Regional Hospital
Recruiting

Unruptured Intracranial Aneurysm Aspirin Trial (UIAAT).

Conditions:   Intracranial Aneurysm;   Inflammation
Intervention:   Drug: Aspirin
Sponsor:   University Hospital Southampton NHS Foundation Trust
Not yet recruiting

Caisson Transcatheter Mitral Valve Replacement (TMVR)

Conditions:   Mitral Regurgitation;   Mitral Valve Disease;   Mitral Valve Failure;   Mitral Disease;   Valve Heart Disease;   Valve Disease, Heart
Intervention:   Device: Transcatheter Mitral Valve Replacement
Sponsor:   Caisson Interventional LLC
Active, not recruiting

Wireless Assessment of Respiratory and Circulatory Distress in Chronic Obstructive Pulmonary Disease - an Observational Study

Condition:   Chronic Obstructive Pulmonary Disease
Intervention:   Device: Continuous monitoring system
Sponsors:   University Hospital Bispebjerg and Frederiksberg;   Technical University of Denmark;   Herlev and Gentofte Hospital
Recruiting

The FAVOR III China Study

Conditions:   Coronary Artery Disease;   Myocardial Ischaemia;   Coronary Circulation;   Coronary Stenosis;   Percutaneous Coronary Intervention
Interventions:   Diagnostic Test: QFR;   Diagnostic Test: Angiography
Sponsors:   China National Center for Cardiovascular Diseases;   Shanghai Jiao Tong University -Pulse Medical Imaging Technology Joint Lab
Not yet recruiting

Treatment of In-Stent Restenosis 2 Study

Condition:   Coronary Restenosis
Interventions:   Device: sirolimus-eluting balloon (SEB) MagicTouch;   Device: paclitaxel-eluting balloon (PEB) Sequent Please
Sponsor:   University Hospital Ostrava
Recruiting

Prasugrel Switching Study in Patients With Acute Coronary Syndrome (ACS) Who Underwent Percutaneous Coronary Intervention (PCI)

Condition:   Acute Coronary Syndrome (ACS)
Intervention:   Drug: Prasugrel
Sponsor:   Daiichi Sankyo Taiwan Ltd., a Daiichi Sankyo Company
Recruiting

The Box 2.0: Using Smart Technology for Early Diagnosis of Complications After Cardiovascular Surgery

Conditions:   Rehabilitation After Cardiovascular Surgery;   Mobile Health
Intervention:   Other: The Box 2.0
Sponsor:   Leiden University Medical Center
Recruiting

The Long Term Effect of Low Dose Aspirin on Uric Acid in Chinese Patients With Coronary Artery Disease(AURORA)

Conditions:   Coronary Artery Disease;   Hyperuricemia
Interventions:   Drug: Aspirin 100 mg;   Drug: Clopidogrel 75mg
Sponsor:   Shanghai Zhongshan Hospital
Recruiting

SOLARIS Endoprosthesis in Iliac Occlusive Disease

Condition:   Peripheral Arterial Disease
Intervention:   Device: Endoprosthesis implantation
Sponsor:   Scitech Produtos Medicos Ltda
Not yet recruiting

Impact of Real-time Angiographic Co-registered OCT on PCI Results - the OPTICO-integration II Study

Condition:   Ischaemic Heart Disease
Interventions:   Procedure: Angio-PCI;   Procedure: OCT-PCI;   Procedure: ACR-PCI
Sponsor:   Charite University, Berlin, Germany
Active, not recruiting

Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity

Conditions:   Overweight;   Obesity
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

Low-dose Dexmedetomidine and Postoperative Delirium After Cardiac Surgery

Conditions:   Cardiac Surgery;   Cardiopulmonary Bypass;   Dexmedetomidine;   Delirium;   Survival
Interventions:   Drug: Dexmedetomidine;   Drug: Placebo
Sponsors:   Dong-Xin Wang;   Fu Wai Hospital, Beijing, China
Not yet recruiting

PRediction of Acute Coronary Syndrome in Acute Ischemic StrokE

Conditions:   Stroke, Ischemic;   Acute Coronary Syndrome
Intervention:   Diagnostic Test: Coronary angiography
Sponsors:   Charite University, Berlin, Germany;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK);   German Center for Neurodegenerative Diseases (DZNE)
Recruiting

Feasibility Study on the Medical and Economic Consequences of Outpatient Management of TIAs and Minor Strokes

Condition:   Transient Ischemic Attack
Intervention:  
Sponsor:   University Hospital, Toulouse
Not yet recruiting

New-Onset Atrial Fibrillation Complicating Myocardial Infarction in ShangHai

Conditions:   Atrial Fibrillation;   Myocardial Infarction
Intervention:   Device: cardiac monitoring
Sponsor:   Shanghai 10th People's Hospital
Recruiting

Medtronic Terminate AF Study

Conditions:   Persistent Atrial Fibrillation;   Longstanding Persistent Atrial Fibrillation
Interventions:   Procedure: Surgical Ablation;   Device: Cardioblate and Cryoflex hand held devices
Sponsor:   Medtronic Cardiovascular
Recruiting

Spironolactone and Perioperative Atrial Fibrillation Occurrence in Cardiac Surgery Patients.

Conditions:   Cardiac Surgery;   Atrial Fibrillation;   Aldosterone Blockade
Interventions:   Drug: Spironolactone 25mg;   Drug: Placebo oral capsule
Sponsors:   University Hospital, Caen;   Ministry of Health, France
Recruiting

A Medical Research Study to Evaluate the Effects of ACT-246475 in Adults With Heart Attack

Condition:   Acute Myocardial Infarction
Intervention:   Drug: ACT-246475
Sponsor:   Idorsia Pharmaceuticals Ltd.
Completed

Study of Dutogliptin in Combination With Filgrastim in Post-Myocardial Infarction

Conditions:   Acute Myocardial Infarction;   Acute Myocardial Ischemia;   STEMI - ST Elevation Myocardial Infarction
Interventions:   Drug: Dutogliptin Tartrate;   Drug: Filgrastim Injectable Product;   Drug: Placebos
Sponsor:   Recardio, Inc.
Recruiting

BIO REsponse Adapted Combination Therapy Pilot Study

Condition:   Peripheral Arterial Disease
Interventions:   Diagnostic Test: Duplex Ultrasound (DUS);   Diagnostic Test: Intraarterial pressure measurement (IAP);   Diagnostic Test: Intraarterial pressure measurement (IAP) with IVUS
Sponsor:   Biotronik AG
Recruiting

POLish Bifurcation Optimal Treatment Strategy Study for Left Main Bifurcation Percutaneous Coronary Intervention (PCI)

Condition:   Coronary Stenosis
Intervention:   Device: BiOSS LIM C
Sponsors:   ECRI bv;   Cardialysis BV;   Balton Sp.zo.o.
Recruiting

Evaluation of Speckle Tracking Parameters as Predictors of Successful VA SPECKLE ECMO

Condition:   Cardiogenic Shock
Intervention:   Other: not applicable, it is an observational study
Sponsor:   Royal Brompton & Harefield NHS Foundation Trust
Recruiting

Effect of Efpeglenatide on Cardiovascular Outcomes

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Efpeglenatide (SAR439977);   Drug: Placebo
Sponsor:   Sanofi
Recruiting

VitamIn and oXygen Interventions and Cardiovascular Events

Condition:   Postoperative Cardiac Complication
Interventions:   Drug: Oxygen;   Drug: Antioxidants
Sponsor:   University Hospital Bispebjerg and Frederiksberg
Recruiting

Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Biological: Apolipoprotein A-I [human] (apoA-I);   Other: Placebo
Sponsor:   CSL Behring
Recruiting

EUROpean Intracoronary Cooling Evaluation in Patients With ST-elevation Myocardial Infarction.

Conditions:   Acute Myocardial Infarction;   Reperfusion Injury
Interventions:   Other: Selective intracoronary hypothermia + PPCI;   Other: Standard PPCI
Sponsors:   Catharina Ziekenhuis Eindhoven;   Abbott;   Golden Jubilee National Hospital;   Onze Lieve Vrouwziekenhuis Aalst;   Rigshospitalet, Denmark;   Örebro University;   Hungarian Institute of Cardiology
Not yet recruiting

Latin America Real World Study With Inspiron Drug Eluting Stent - INSPIRON LATITUDE

Condition:   Coronary Artery Disease
Intervention:   Device: Angioplasty
Sponsor:   Scitech Produtos Medicos Ltda
Recruiting

Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD

Condition:   Coronary Artery Disease
Interventions:   Drug: High dose potent statin;   Drug: ACE-I (lisinopril) or ARB (losartan);   Drug: Aspirin;   Behavioral: Lifestyle Counseling;   Behavioral: Quality of Life Questionnaires
Sponsors:   University of Florida;   United States Department of Defense
Recruiting

World Maternal Antifibrinolytic Trial_2

Condition:   Intrapartum - Moderate and Severe Anaemia
Interventions:   Drug: Tranexamic Acid;   Other: Placebo
Sponsors:   London School of Hygiene and Tropical Medicine;   Wellcome Trust;   Bill and Melinda Gates Foundation
Not yet recruiting

Cooking for Health Optimization With Patients

Conditions:   Cardiovascular Diseases;   Cardiovascular Risk Factor;   Nutrition Disorders;   Diabetes;   Hypertension;   Cancer;   Depression;   Obesity;   Physical Activity
Intervention:   Behavioral: Treatment
Sponsor:   Tulane University
Recruiting

Xarelto for Real Life Anticoagulation in Pulmonary Embolism (PE) in China

Condition:   Pulmonary Embolism
Intervention:   Drug: Rivaroxaban(Xarelto, BAY 59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting

Safety and Efficacy of LMWH Versus Rivaroxaban in Chinese Patients Hospitalized With Acute Coronary Syndrome

Conditions:   Acute Coronary Syndrome;   Myocardial Infarction;   Myocardial Ischemia;   Unstable Angina
Interventions:   Drug: Rivaroxaban 2.5 mg;   Drug: Rivaroxaban 5 mg;   Drug: Enoxaparin
Sponsor:   Second Xiangya Hospital of Central South University
Recruiting

Impact of Renin-Angiotensin System Inhibitors Continuation on Outcome After Major Surgery

Conditions:   Renin Angiotensin System;   Surgery
Interventions:   Procedure: continuation of the RAS-inhibitors;   Procedure: discontinuation of the RAS-inhibitors
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting

XIENCE 28 Global Study

Conditions:   Bleeding Disorder;   Stroke, Ischemic;   Stroke Hemorrhagic;   Hematological Disease;   Thrombocytopenia;   Coagulation Disorder;   Anemia;   Renal Insufficiency;   Coronary Artery Disease
Interventions:   Device: XIENCE;   Drug: DAPT
Sponsor:   Abbott Medical Devices
Recruiting

Comparative Effectiveness of Empagliflozin in the US

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Empagliflozin;   Drug: DPP-4 inhibitor
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting

Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean

Conditions:   Obstetrical Complications;   Hemorrhage;   Labor and Delivery
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsors:   The George Washington University Biostatistics Center;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Hospitalized Participants With Influenza A Infection

Condition:   Influenza A
Interventions:   Drug: Pimodivir 600 mg;   Drug: Placebo;   Other: SOC Treatment
Sponsor:   Janssen Research & Development, LLC
Recruiting

Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk

Conditions:   Type 2 Diabetes Mellitus;   Chronic Kidney Diseases
Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: Placebo
Sponsor:   Sanofi
Recruiting

Low Voltage-Directed Catheter Ablation for Atrial Fibrillation

Condition:   Atrial Fibrillation - Symptomatic
Intervention:   Procedure: Radiofrequency ablation
Sponsors:   Ohad Ziv;   Biosense Webster, Inc.
Recruiting

This Study Looks at the Effects of Idarucizumab in Patients Who Take Dabigatran and Need Emergency Surgery or Are Bleeding

Condition:   Atrial Fibrillation
Intervention:   Drug: Idarucizumab
Sponsor:   Boehringer Ingelheim
Recruiting

HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

Condition:   Kidney Cancer
Intervention:   Biological: cell infusion
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   Loyola University Medical Center (LUMC)
Recruiting

Comparison of CLSB With Sedation Versus General Endotracheal Anesthesia on Postoperative Outcomes in Elderly Patients Undergoing Hip Fracture Surgery

Conditions:   Anesthesia Morbidity;   Anesthesia; Adverse Effect
Intervention:   Procedure: anesthesia
Sponsor:   Xiaofeng WANG
Recruiting

XIENCE 90: A Safety Evaluation of 3-month DAPT After XIENCE Implantation for HBR Patients.

Condition:   Coronary Artery Lesions
Interventions:   Device: XIENCE;   Drug: DAPT
Sponsor:   Abbott Medical Devices
Recruiting

Early Management Strategies of Acute Heart Failure for Patients With NSTEMI

Conditions:   Early Management;   Acute Heart Failure;   NSTEMI - Non-ST Segment Elevation MI
Intervention:   Drug: Regular management+Levosimendan
Sponsor:   Qilu Hospital of Shandong University
Enrolling by invitation

Safety and Efficacy of the SurVeil™ Drug-Coated Balloon

Conditions:   Peripheral Arterial Disease;   Peripheral Vascular Disease;   Artery Disease, Peripheral;   Femoropopliteal Artery Occlusion
Interventions:   Device: Surmodics SurVeil DCB;   Device: Medtronic IN.PACT Admiral DCB
Sponsor:   SurModics, Inc.
Recruiting

A Phase 4 Safety and Efficacy Study to Evaluate Lesinurad 200 mg in Participants With Gout and Renal Impairment

Conditions:   Gout;   Chronic Kidney Disease (CKD)
Interventions:   Drug: Lesinurad;   Drug: XOI;   Drug: Placebo
Sponsors:   Ironwood Pharmaceuticals, Inc.;   Medpace, Inc.
Recruiting

Patent Foramen Ovale (PFO) Closure at the Time of Endovascular Cardiac Electronic Device Implantation

Condition:   Foramen Ovale, Patent
Interventions:   Drug: Aspirin;   Device: Cardiovascular Implantable Device (CIED);   Device: Gore Cardioform Septal Occluder
Sponsor:   Mayo Clinic
Not yet recruiting

Prospective, Non-interventional Study to Evaluate the Safety and Effectiveness of Obizur in Real-life Practice

Condition:   Acquired Hemophilia A
Intervention:   Biological: OBIZUR
Sponsors:   Baxalta now part of Shire;   Baxalta Innovations GmbH, now part of Shire
Recruiting

Safety and Efficacy of Low Dosage of Terazosin in Subjects Undergoing Carotid Artery Stenting

Condition:   Carotid Artery Stenosis
Interventions:   Drug: Terazosin;   Procedure: Carotid artery stenting
Sponsors:   Capital Medical University;   The Luhe Teaching Hospital of the Capital Medical University;   Beijing Anzhen Hospital
Recruiting

Real-world Use and Prognosis of Beta Blocker in Patients With Acute Coronary Syndrome in the Central China

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   Henan Institute of Cardiovascular Epidemiology
Recruiting

Safety of Accelerated Rule-out Protocols in Patients Admitted With Chest Pain to a Crowded Chest Pain Unit (CPU)

Conditions:   Acute Coronary Syndrome;   NSTEMI - Non-ST Segment Elevation MI
Intervention:   Diagnostic Test: NSTEMI Rule-Out according to hs-TnT
Sponsor:   University Hospital Heidelberg
Completed

Effect of Remote Ischemic Post-conditioning on Out-of-hospital Cardiac Arrest

Condition:   Out-Of-Hospital Cardiac Arrest
Intervention:   Procedure: Remote ischemic post-conditioning
Sponsor:   Chonnam National University Hospital
Active, not recruiting

Investigating Idiopathic Pulmonary Fibrosis in Greece (INDULGE IPF)

Condition:   Idiopathic Pulmonary Fibrosis
Intervention:  
Sponsor:   Boehringer Ingelheim
Recruiting

Smartphone Twelve Lead Electrocardiogram Utility In ST-Elevation Myocardial Infarction

Condition:   STEMI
Interventions:   Device: Smartphone ECG;   Device: Standard 12-lead ECG
Sponsors:   Mayo Clinic;   AliveCor
Completed

The Box: Using Smart Technology to Improve One-year Outcome of Myocardial Infarction Patients

Condition:   Myocardial Infarction
Intervention:   Other: The Box
Sponsor:   Leiden University Medical Center
Completed

Comparative Effectiveness of Cardiovascular Outcomes in New Users of SGLT-2 Inhibitors

Condition:   Diabetes Mellitus Type 2
Intervention:  
Sponsor:   AstraZeneca
Recruiting

ACURATE TF™ Transfemoral Aortic Bioprosthesis for Implantation in Patients With Severe Aortic Stenosis:CE-approval Cohort

Condition:   Symptomatic Aortic Stenosis
Intervention:   Device: ACURATE TF™
Sponsor:   Symetis SA
Completed

Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics

Conditions:   Osteomyelitis;   Diabetes;   Amputation
Interventions:   Drug: Rifampin;   Drug: Riboflavin Placebo
Sponsor:   VA Office of Research and Development
Recruiting

Erythrocyte Transfusion Based on the Measurement of Central Venous Oxygen Saturation in Postoperative Cardiac Surgery

Condition:   Cardiac Surgery
Intervention:   Other: SVO2 group / control group
Sponsor:   Centre Hospitalier Universitaire, Amiens
Recruiting

Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI

Condition:   Acute Myocardial Infarction
Interventions:   Drug: LCZ696 (sacubitril/valsartan);   Drug: Ramipril;   Drug: Placebo of LCZ696;   Drug: Placebo of ramipril;   Drug: Valsartan;   Drug: Placebo of valsartan
Sponsor:   Novartis Pharmaceuticals
Recruiting

Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

Conditions:   Prediabetic State;   Atherosclerosis;   Metformin
Interventions:   Drug: Metformin XR;   Drug: Placebo
Sponsor:   VA Office of Research and Development
Not yet recruiting

Aspirin in Preventing Recurrence of Cancer in Patients With HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy

Condition:   Node Positive HER2 Negative Breast Cancer
Interventions:   Other: Placebo;   Drug: Aspirin
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   United States Department of Defense;   Bayer;   Canadian Cancer Trials Group
Recruiting

Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Subjects With Dialysis-dependent Chronic Kidney Disease (DD-CKD)

Condition:   Anemia in Subjects With DD-CKD
Interventions:   Drug: vadadustat;   Drug: darbepoetin alfa
Sponsor:   Akebia Therapeutics
Recruiting

Thin Strut Sirolimus-eluting Stent in All Comers Population vs Everolimus-eluting Stent

Condition:   Coronary Stenosis
Interventions:   Device: SUPRAFLEX;   Device: XIENCE
Sponsors:   ECRI bv;   Sahajanand Medical Technologies Pvt. Ltd.
Active, not recruiting

Efficacy and Safety Study to Evaluate Vadadustat for the Correction or Maintenance Treatment of Anemia in Subjects With Incident Dialysis-dependent Chronic Kidney Disease (DD-CKD)

Conditions:   Anemia;   Dialysis-dependent Chronic Kidney Disease
Interventions:   Drug: vadadustat;   Drug: Darbepoetin alfa
Sponsor:   Akebia Therapeutics
Recruiting

Edoxaban Treatment Versus Vitamin K Antagonist in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention

Condition:   Atrial Fibrillation
Interventions:   Drug: Edoxaban;   Drug: Clopidogrel;   Drug: Prasugrel;   Drug: ticagrelor
Sponsor:   Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Active, not recruiting

Antiplatelet Therapy in Acute Mild-Moderate Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: clopidogrel;   Drug: Aspirin
Sponsor:   General Hospital of Shenyang Military Region
Recruiting

Effect of Testosterone Replacement on Exercise Capacity in Hypogonadal Men After a Recent Myocardial Infarction

Conditions:   Hypogonadism;   Acute Myocardial Infarction: Rehabilitation Phase
Interventions:   Drug: Testosterone;   Drug: Normal Saline
Sponsor:   Texas Tech University Health Sciences Center
Recruiting

Randomised Evaluation of Sodium Dialysate Levels on Vascular Events

Condition:   End-Stage Kidney Disease
Interventions:   Other: Default dialysate sodium concentration of 137mmol/l;   Other: Default dialysate sodium concentration of 140mmol/l
Sponsors:   The George Institute;   Australasian Kidney Trials Network
Recruiting

Scandinavian Multicenter Study to Advance Risk Stratification in Heart Disease- Ventricular Arrhythmias

Conditions:   Ventricular Arrhythmias;   Implantable Defibrillator User;   Biological Markers;   Heart Disease
Intervention:  
Sponsors:   University Hospital, Akershus;   Helse Stavanger HF;   University of Oslo
Recruiting

Multicenter Automatic Defibrillator Implantation Trial With Subcutaneous Implantable Cardioverter Defibrillator

Conditions:   Tachycardia;   Diabetes Mellitus;   Cardiovascular Disease
Intervention:   Device: Subcutaneous Implantable Cardioverter Defibrillator
Sponsors:   Boston Scientific Corporation;   University of Rochester
Active, not recruiting

Prognosis of Coronary Stenosis Based on Intracoronary Imaging; A Multicenter, Prospective Observational Study

Condition:   Coronary Artery Disease
Intervention:   Other: 5-year Follow-up
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea
Recruiting

Caisson Transcatheter Mitral Valve Replacement (TMVR) System Early Feasibility Study

Condition:   Mitral Valve Regurgitation
Intervention:   Device: Caisson TMVR System
Sponsor:   Caisson Interventional LLC
Active, not recruiting

Cardiogoniometry for Detecting Coronary Artery Disease by CT Angiography

Conditions:   Coronary Heart Disease;   Coronary Artery Disease;   Ischemic Heart Disease
Intervention:   Device: Explorer
Sponsors:   Johns Hopkins University;   Enverdis Corp.
Recruiting

Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Subjects With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)

Conditions:   Anemia;   Non-dialysis-dependent Chronic Kidney Disease
Interventions:   Drug: vadadustat;   Drug: darbepoetin alfa
Sponsor:   Akebia Therapeutics
Recruiting

Efficacy and Safety Study to Evaluate Vadadustat for the Correction of Anemia in Subjects With Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD)

Conditions:   Anemia;   Non-dialysis-dependent Chronic Kidney Disease
Interventions:   Drug: vadadustat;   Drug: darbepoetin alfa
Sponsor:   Akebia Therapeutics
Recruiting

Aiming Towards Evidence Based Interpretation of Cardiac Biomarkers in Patients Presenting With Chest Pain

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsors:   Haukeland University Hospital;   Helse Stavanger HF;   The Royal Norwegian Ministry of Health
Recruiting

Randomized Trial of COBRA PzF Stenting to Reduce Duration of Triple Therapy

Conditions:   Angina, Stable;   Angina, Unstable;   Anticoagulants
Interventions:   Device: COBRA PzF;   Device: Drug Eluting Stent
Sponsor:   CeloNova BioSciences, Inc.
Recruiting

Feasibility Study of a Left Atrial Appendage Closure Device in Patients With Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Device: Aegis Sierra Ligation System
Sponsors:   Aegis Medical Innovations;   Applied Health Research Centre
Recruiting

Vorapaxar as an Add-On Antiplatelet Therapy in Patients With and Without Diabetes Mellitus

Conditions:   Myocardial Infarction;   Diabetes Mellitus;   Peripheral Arterial Disease
Interventions:   Drug: Vorapaxar;   Drug: Clopidogrel;   Drug: Aspirin
Sponsors:   University of Florida;   Merck Sharp & Dohme Corp.
Recruiting

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Apixaban After Anticoagulation-associated Intracerebral Haemorrhage in Patients With Atrial Fibrillation

Conditions:   Cerebral Hemorrhage;   Atrial Fibrillation
Interventions:   Drug: Apixaban;   Drug: Aspirin;   Drug: Carbasalate calcium;   Drug: Clopidogrel;   Drug: Dipyridamole;   Other: No antithrombotic treatment
Sponsors:   UMC Utrecht;   Dutch Heart Foundation;   ZonMw: The Netherlands Organisation for Health Research and Development
Recruiting

Phase I Safety and Feasibility Study of Intracoronary Delivery of Autologous Bone Marrow Derived Mononuclear Cells

Condition:   Congenital Heart Disease
Intervention:   Biological: Autologous Bone Marrow-derived Mononuclear Cells
Sponsor:   Timothy J. Nelson
Active, not recruiting

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Active, not recruiting

Prospective Record Of the Use of Dabigatran in Patients With Acute Stroke or TIA

Conditions:   Brain Ischemia With Non-valvular Atrial Fibrillation;   Transient Ischemic Attack With Non-valvular Atrial Fibrillation
Intervention:  
Sponsor:   University Hospital, Essen
Recruiting

A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart

Condition:   Acute Coronary Syndromes
Interventions:   Drug: Apixaban;   Drug: vitamin K antagonist;   Drug: Acetylsalicylic acid;   Other: Acetylsalicylic acid placebo
Sponsors:   Bristol-Myers Squibb;   Pfizer;   Duke Clinical Research Institute
Completed

Medtronic RESOLUTE ONYX Core (2.25 mm - 4.0 mm) Clinical Study

Condition:   Coronary Artery Disease
Intervention:   Device: Resolute Onyx Stent - 2.25 mm - 4.0 mm
Sponsor:   Medtronic Vascular
Active, not recruiting

MagicTouch Sirolimus Drug Coated Balloon Catheter for the Treatment of Coronary Lesions

Condition:   Coronary Artery Disease
Intervention:   Device: MAGIC-TOUCH Drug-eluting Balloon
Sponsor:   Scitech Produtos Medicos Ltda
Active, not recruiting

Heterotopic Implantation Of the Edwards-Sapien Transcatheter Aortic Valve in the Inferior VEna Cava for the Treatment of Severe Tricuspid Regurgitation (HOVER)

Condition:   Tricuspid Regurgitation
Intervention:   Device: Heterotopic Implantation Of the Edwards-Sapien XT Transcatheter Valve in the Inferior VEna Cava
Sponsor:   Temple University
Recruiting

Chronic Hypertension and Pregnancy (CHAP) Project

Condition:   Hypertension
Interventions:   Drug: Anti-hypertensive therapy;   Other: No anti-hypertensive therapy (unless BP is severe)
Sponsors:   University of Alabama at Birmingham;   Columbia University;   Drexel University College of Medicine;   Rutgers, The State University of New Jersey;   Lehigh Valley Hospital;   Saint Peters University Hospital;   Christiana Care Health Services;   Washington University School of Medicine;   Duke University;   University of Texas Southwestern Medical Center;   The University of Texas Health Science Center, Houston;   Stanford University;   University of Pennsylvania;   The University of Texas Medical Branch, Galveston;   University of Utah;   Intermountain Health Care, Inc.;   University of California, San Francisco;   Johns Hopkins University;   University of Pittsburgh;   Ochsner Health System;   University of North Carolina, Chapel Hill;   National Heart, Lung, and Blood Institute (NHLBI);   WakeMed Health and Hospitals;   San Francisco General Hospital;   McKay-Dee Hospital;   Winthrop University Hospital;   New York Hospital Queens;   Latter Day Saints Hospital;   Lyndon B Johnson General Hospital;   Virtua Medical Group;   Bayview Medical Center;   Duke Regional Hospital;   Utah Valley Regional Medical Center;   Northwestern;   Brown (WIHRI);   Baylor College of Medicine;   Case Western/Metro Health;   Ohio State University;   University of Iowa;   University of California, San Diego;   Indiana University;   Unity Point Health-Meriter Hospital WI;   Weill Medical College of Cornell University;   University of Oklahoma;   Medical University of South Carolina;   Beaumont Hospital;   University of Colorado, Denver;   University of Kansas Medical Center;   Denver Health and Hospital Authority;   Gundersen Health System;   Aurora Health Care;   Oregon Health and Science University;   Medical College of Wisconsin;   Temple University;   New Jersey Medical School;   University of South Alabama;   Vanderbilt University;   University of Arkansas;   Miami Valley Hospital;   Emory University;   St. Luke's Hospital and Health Network, Pennsylvania;   Cleveland Clinic Fairview Hospital;   University of Tennessee Health Science Center;   TriHealth Inc.;   Cleveland Clinic Hillcrest Hospital
Recruiting

Clinical Outcomes and Radiation Safety After Endovascular Repair of Complex AAAs Using Fenestrated- Branched Devices

Condition:   Aortic Aneurysm, Abdominal
Interventions:   Device: Fenestrated CMD;   Device: Type I - III TAAA
Sponsor:   University of Texas Southwestern Medical Center
Recruiting

Early Rheumatoid Arthritis COR Intervention

Conditions:   Rheumatoid Arthritis;   Cardiovascular Diseases
Interventions:   Other: Simvastatin;   Other: Losartan;   Other: Metformin;   Other: Outpatient rheumatology department;   Other: Refered to general practice
Sponsor:   MD, PhD, Annemarie Lyng Svensson
Recruiting

Myocardial Hybrid Revascularization Versus Coronary artERy Bypass GraftING for Complex Triple-vessel Disease

Condition:   Multivessel Coronary Artery Disease
Interventions:   Procedure: Hybrid Revascularization;   Procedure: Conventional Coronary Artery Bypass Surgery
Sponsors:   InCor Heart Institute;   Boston Scientific Corporation
Active, not recruiting

Active Surveillance Research Program for the Assessment of the Safety and the Effectiveness of Linagliptin

Condition:   Diabetes Mellitus, Type 2
Intervention:  
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting

Affect of Health Education on Statins Medication Persistence and ClinicaL Prognosis of Ischemic Stroke Patients (HELP)

Condition:   Ischemic Stroke
Interventions:   Behavioral: multiple health education interventions;   Behavioral: conventional health education
Sponsors:   yongjun wang;   Ministry of Science and Technology of the People´s Republic of China
Completed

Affect of Multiple Health Education on Medication Persistence and Clinical Prognosis of Ischemic Stroke Patients

Conditions:   Ischemic Stroke;   Medication Persistence
Intervention:   Behavioral: multiple health education interventions
Sponsors:   yongjun wang;   Ministry of Science and Technology of the People´s Republic of China
Completed

Safety and Efficacy of Ticagrelor Versus Clopidogrel in Asian/KOREAn Patients With Acute Coronary Syndromes Intended for Invasive Management

Conditions:   Acute Coronary Syndrome;   Myocardial Ischemia;   Heart Diseases;   Cardiovascular Diseases;   Angina Pectoris
Interventions:   Drug: Ticagrelor;   Drug: Clopidogrel
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea
Completed

Platelet Activity in Vascular Surgery and Cardiovascular Events

Conditions:   Cardiovascular Disease;   Peripheral Artery Disease;   Critical Limb Ischemia
Intervention:  
Sponsors:   New York University School of Medicine;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Completed

A Study of the Gore VIABAHN BX for Treatment of Occlusive Disease in the Iliac Arteries.

Condition:   Peripheral Arterial Disease
Intervention:   Device: Stenting of the Common and/or External Iliac Arteries
Sponsor:   W.L.Gore & Associates
Completed

Proteomic Prediction and Renin Angiotensin Aldosterone System Inhibition Prevention Of Early Diabetic nephRopathy In TYpe 2 Diabetic Patients With Normoalbuminuria

Conditions:   Diabetic Nephropathy;   Diabetic Retinopathy
Interventions:   Drug: Spironolactone;   Drug: Placebo;   Drug: Standard care
Sponsors:   Peter Rossing;   Mosaiques Diagnostics GmbH;   University Medical Center Groningen;   University of Glasgow;   Istituto Di Ricerche Farmacologiche Mario Negri;   Univerzita Karlova v Praze;   Geniko Nosokomeio Athinas Ippokrateio;   Institut Klinické a Experimentální Mediciny Praze;   Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz;   Klinikum St. Georg Leipzig;   Cyril and Methodius University in Skopje;   Hannover Clinical Trial Center;   European Commission;   Diabetes Vascular Research Foundation Hoogeveen;   Universitair Ziekenhuis Gent;   Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden;   Stichting VUMC;   Diabetologen Hessen
Completed

Evaluate the Effect of Aclidinium Bromide on Long-term Cardiovascular Safety and Exacerbations in Moderate to Very Severe COPD Patients.

Conditions:   COPD;   Chronic Obstructive Pulmonary Disease;   Moderate to Very Severe COPD
Interventions:   Drug: Aclidinium Bromide;   Drug: Placebo
Sponsor:   AstraZeneca
Completed

Real World Expanded Multicenter Study of the MitraClip® System (REALISM)

Conditions:   Mitral Valve Insufficiency;   Mitral Valve Regurgitation;   Mitral Valve Incompetence;   Mitral Regurgitation;   Mitral Insufficiency
Intervention:   Device: MitraClip® implant
Sponsor:   Abbott Medical Devices
Completed

Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® Induction

Condition:   Renal Transplant
Intervention:   Drug: Arm 1 Everolimus/Reduced dose tacrolimus
Sponsors:   University of Toledo Health Science Campus;   Novartis Pharmaceuticals
Active, not recruiting

Evaluation of the GORE® EXCLUDER® Iliac Branch Endoprosthesis

Conditions:   Common Iliac Artery Aneurysms;   Aorto-iliac Aneurysms
Intervention:   Device: GORE® EXCLUDER® Iliac Branch Endoprosthesis
Sponsor:   W.L.Gore & Associates
Active, not recruiting

An Evaluation of Clinical Pharmacist-led Intervention on Clinical Outcomes in Patients With Ischemic Stroke

Condition:   Stroke
Interventions:   Other: Intervention (CPCRS) Group;   Other: Placebo
Sponsor:   Kaiser Permanente
Completed

ALdosterone Antagonist Chronic HEModialysis Interventional Survival Trial

Condition:   End Stage Renal Failure on Dialysis
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   University Hospital, Brest;   Central Hospital, Nancy, France;   Institut National de la Santé Et de la Recherche Médicale, France
Recruiting

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention & Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Population Health Research Institute;   Janssen Research & Development, LLC
Active, not recruiting

ABSORB III Randomized Controlled Trial (RCT)

Conditions:   Coronary Artery Disease;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Stenosis
Interventions:   Device: Absorb BVS;   Device: XIENCE
Sponsor:   Abbott Medical Devices
Active, not recruiting

ClearWay Rx Readmission Registry

Condition:   Acute Myocardial Infarction
Intervention:   Device: ClearWay™ Rx catheter
Sponsor:   Cardiovascular Institute of the South Clinical Research Corporation
Completed

Haemorrhage Alleviation With Tranexamic Acid- Intestinal System

Condition:   Gastrointestinal Bleeding
Interventions:   Drug: Tranexamic Acid;   Drug: Placebo
Sponsors:   London School of Hygiene and Tropical Medicine;   Global trial which will include about 40 countries and over 200 hospitals
Recruiting

AngioSeal Versus Radial Approach in Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Intervention:   Device: Percutaneous coronary intervention
Sponsor:   Irmandade Santa Casa Misericórdia Marília
Completed

Evaluating New Radiation Techniques for Cardiovascular Imaging

Condition:   Coronary Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Left Atrial Appendage Occlusion Study III

Conditions:   Cardiac Surgery With Cardiopulmonary Bypass;   Atrial Fibrillation
Intervention:   Other: Left Atrial Appendage Occlusion
Sponsor:   Population Health Research Institute
Active, not recruiting

GLORIA-AF Registry Program - Second and Third Phases

Conditions:   Stroke;   Atrial Fibrillation
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting

A Study of Pertuzumab in Addition to Chemotherapy and Trastuzumab as Adjuvant Therapy in Participants With Human Epidermal Growth Receptor 2 (HER2)-Positive Primary Breast Cancer

Condition:   Breast Cancer
Interventions:   Drug: 5-Fluorouracil;   Drug: Carboplatin;   Drug: Cyclophosphamide;   Drug: Docetaxel;   Drug: Doxorubicin;   Drug: Epirubicin;   Drug: Paclitaxel;   Drug: Pertuzumab;   Drug: Placebo;   Drug: Trastuzumab
Sponsors:   Hoffmann-La Roche;   Genentech, Inc.;   Breast International Group
Active, not recruiting

Research Study of ATG and Rituximab in Renal Transplantation

Condition:   Renal Transplant Recipients
Interventions:   Drug: ATG;   Drug: Rituximab;   Drug: Tacrolimus;   Drug: Sirolimus;   Drug: MMF
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Immune Tolerance Network (ITN)
Terminated

Warfarin - How Good Are we at Maintaining Target Range ?

Condition:   Atrial Fibrillation
Intervention:  
Sponsors:   University of Dundee;   NHS Tayside
Completed

CANVAS - CANagliflozin cardioVascular Assessment Study

Conditions:   Diabetes Mellitus, Type 2;   Cardiovascular Diseases;   Risk Factors
Interventions:   Drug: Placebo;   Drug: Canagliflozin (JNJ-28431754) 100 mg;   Drug: Canagliflozin (JNJ-28431754) 300 mg
Sponsors:   Janssen Research & Development, LLC;   The George Institute for Global Health, Australia
Completed

Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial

Condition:   Ischemic Attack, Transient
Interventions:   Drug: Clopidogrel;   Drug: placebo
Sponsors:   University of California, San Francisco;   Neurological Emergencies Treatment Trials Network (NETT);   Medical University of South Carolina;   The EMMES Corporation
Terminated

Imaging Modalities in Detection of Coronary Artery Disease in End-stage Renal Disease Patients

Conditions:   Coronary Artery Disease;   Myocardial Infarction;   Stroke;   Death
Intervention:  
Sponsor:   University of Nebraska
Completed

Insulin Resistance and Atherosclerosis in Women With Lupus

Conditions:   Systemic Lupus Erythematosus;   Insulin Resistance;   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Completed

Effect of Diet on Vascular Disease in Pre-Menopausal Women

Conditions:   Cardiovascular Diseases;   Vascular Disease;   Inflammation;   Insulin;   Triglycerides
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Genetic Factors in Atherosclerosis

Condition:   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Completed

Stem Cell Transplantation and T-Cell Add-Back to Treat Bone Marrow Malignances

Conditions:   Immunosuppression;   Leukemia
Intervention:   Device: SOLEX 300i Stem Cell Selection
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Aspirin Dose and Atherosclerosis in Patients With Heart Disease

Conditions:   Cardiovascular Diseases;   Atherosclerosis;   Myocardial Infarction
Intervention:   Drug: Aspirin
Sponsors:   Florida Atlantic University;   Bayer
Completed

Aspirin Dose and Atherosclerosis in Patients With Metabolic Syndrome

Conditions:   Cardiovascular Diseases;   Metabolic Syndrome X;   Atherosclerosis
Intervention:   Drug: Aspirin
Sponsors:   Florida Atlantic University;   Bayer
Completed

Angiomax in Patients With HIT/HITTS Type II Undergoing Off-Pump Coronary Artery Bypass Grafting (CABG) (CHOOSE)

Conditions:   Thrombocytopenia;   Thrombosis;   Cardiac Disease;   Coronary Artery Bypass Surgery
Intervention:   Drug: Angiomax (bivalirudin) anticoagulant
Sponsor:   The Medicines Company
Completed

Technical Development of Cardiovascular Magnetic Resonance Imaging

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Suspended