Heart Attack

Clinical Trial Finder

Many patients with heart disease are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Safety Evaluation of Intracoronary Infusion of Extracellular Vesicles in Patients With AMI

Condition:   Heart Attack
Intervention:   Drug: PEP in Acute Myocardial Infarction
Sponsor:   Paul G. Stalboerger
Not yet recruiting

Examining Heart Attacks in Young Women

Condition:   Acute Myocardial Infarction
Intervention:  
Sponsors:   Yale University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Accelerated Rule Out of Myocardial Infarction

Condition:   Myocardial Infarction
Intervention:   Procedure: Accelerated, combined biomarker rule-out strategy for MI
Sponsor:   Aarhus University Hospital Skejby
Completed

ASV for Sleep Apnea After Myocardial Infarction

Conditions:   Acute Myocardial Infarction;   Sleep Apnea
Intervention:   Device: Adaptive servo-ventilation
Sponsors:   University Hospital Regensburg;   ResMed Foundation
Recruiting

MULTivessel Immediate Versus STAged RevaScularization in Acute Myocardial Infarction -The MULTISTARS AMI Trial

Conditions:   ST-elevation Myocardial Infarction;   Multivessel Coronary Disease
Interventions:   Procedure: Staged complete PCI;   Procedure: Immediate complete PCI;   Device: Synergy™ stent
Sponsor:   University of Zurich
Recruiting

TicAgrelor Versus CLOpidogrel in Stabilized Patients With Acute Myocardial Infarction: TALOS-AMI

Condition:   Acute Myocardial Infarction
Interventions:   Drug: Aspirin+Ticagrelor;   Drug: Aspirin+Clopidogrel
Sponsors:   The Catholic University of Korea;   Chonnam National University Hospital
Completed

Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: The STEMI-DTU Trial

Condition:   ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
Intervention:   Device: Impella CP® placement prior to reperfusion with Primary PCI
Sponsor:   Abiomed Inc.
Recruiting

Prochymal® (Human Adult Stem Cells) Intravenous Infusion Following Acute Myocardial Infarction (AMI)

Condition:   Myocardial Infarction
Interventions:   Drug: Prochymal®;   Drug: Placebo
Sponsor:   Mesoblast, Inc.
Completed

High-Intensity Interval Training Early After Left Ventricular Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Other: HIIT;   Other: MICE
Sponsor:   University Hospital Inselspital, Berne
Active, not recruiting

Fast Radial Pharmaco-invasive Strategy In ST Elevation Myocardial Infarction Trial

Condition:   ST-segment Elevation Myocardial Infarction (STEMI)
Interventions:   Procedure: Cardiac catheterization standard strategy;   Procedure: Cardiac catheterization fast strategy
Sponsor:   University of Sao Paulo General Hospital
Recruiting

Association of Long-term Conditions With Survival Following Heart Attack in England and Wales

Conditions:   Acute Myocardial Infarction;   Diabetes Mellitus;   Peripheral Vascular Disease;   Chronic Heart Failure;   Cerebrovascular Disease;   Chronic Renal Failure;   Chronic Obstructive Pulmonary Disease
Intervention:   Other: long term conditions
Sponsor:   Marlous Hall
Active, not recruiting

HELicobacter Pylori Screening in Patients With Acute Myocardial Infarction Pilot Study

Conditions:   STEMI - ST Elevation Myocardial Infarction;   NSTEMI - Non-ST Segment Elevation MI
Intervention:   Diagnostic Test: Helicobacter Pylori screening by UBT
Sponsor:   Karolinska Institutet
Recruiting

Biomarkers in Acute Cardiac Care

Conditions:   Acute Coronary Syndrome;   Myocardial Infarction;   Chest Pain
Intervention:  
Sponsor:   Universitätsklinikum Hamburg-Eppendorf
Recruiting

Effects of Morphine on Loading-dose Ticagrelor in Patients With ST-segment Elevation Myocardial Infarction

Condition:   ST-segment Elevation Myocardial Infarction
Interventions:   Drug: Morphine;   Drug: metoclopramide;   Drug: saline
Sponsor:   General Hospital of Chinese Armed Police Forces
Recruiting

Early Diagnosis of Acute Myocardial Infarction: Impact of an Educational and Organizational Intervention

Conditions:   STEMI;   Myocardial Infarction;   Nurses;   Education;   Emergency Room
Interventions:   Other: Educational and organizational intervention;   Other: Common Practice
Sponsor:   Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Recruiting

Paroxetine-mediated GRK2 Inhibition to Reduce Cardiac Remodeling After Acute Myocardial Infarction

Conditions:   Cardiac Remodeling;   Myocardial Infarction
Interventions:   Drug: Paroxetine;   Drug: Placebo oral capsule
Sponsor:   University Hospital Inselspital, Berne
Recruiting

DPP-4 Inhibitors and Acute Myocardial Infarction:Effects on Platelet Function

Condition:   Platelet Aggregation During Acute Myocardial Infarction
Interventions:   Drug: sitagliptin OR saxagliptin;   Drug: placebo
Sponsors:   University of Sao Paulo General Hospital;   InCor Heart Institute
Recruiting

Physical Activity Intervention in ELderly Patients With Myocardial INfarction

Conditions:   Myocardial Infarction;   Aging
Interventions:   Other: Health Education;   Other: Exercise Intervention
Sponsors:   University Hospital of Ferrara;   Azienda Usl di Bologna
Recruiting

Intervention in Frailty Versus Usual Care in Frail Patients After an Acute Myocardial Infarction

Condition:   Fragility
Intervention:   Other: Intervention on frailty
Sponsor:   University of Valencia
Completed

Factor XIII and Other Biomarkers in ST Segment Elevation Myocardial Infarction

Conditions:   Factor XIII Deficiency;   ST-Elevation Myocardial Infarction;   Myocardial Haemorrhage;   Coronary Microvascular Disease
Intervention:  
Sponsor:   University of Padova
Active, not recruiting

A Phase 2 Open Label Study to Assess the PK/PD Properties of RUC-4 in Patients With a ST-elevation Myocardial Infarction

Conditions:   Coronary Disease;   Myocardial Infarction;   Heart Diseases;   Vascular Diseases;   STEMI - ST Elevation Myocardial Infarction
Intervention:   Drug: RUC-4 Compound
Sponsors:   CeleCor Therapeutics;   ST. Antonius hospital Nieuwegein;   Diagram B.V.
Not yet recruiting

Facilitating Catheter Guidance to Optimal Site for VT Ablation

Condition:   Post-myocardial Infarction Ventricular Tachycardia
Intervention:   Procedure: Radiofrequency catheter ablation
Sponsors:   University of Exeter;   Medical Research Council;   EPSRC;   University Hospitals Bristol NHS Foundation Trust
Not yet recruiting

Study of Circulating Monocytes in Patients With Ischemic Vascular Disease

Conditions:   Myocardial Infarction;   Stroke, Ischemic;   Ischemia
Intervention:   Other: There is no intervention given to the subjects
Sponsor:   UConn Health
Recruiting

Quantitative Fractional Ratio-guided Revascularization in STEMI Patients With Multi-vessel Disease

Conditions:   ST Elevation Myocardial Infarction;   Multi-Vessel Coronary Artery Stenosis
Intervention:   Procedure: PCI
Sponsors:   Fujian Medical University;   Pulse Medical Imaging Technology (Shanghai) Co., Ltd
Enrolling by invitation

Assessment of the Effects of Atorvastatin Therapy on Myocardial Deformation Characteristics, in Patients With STEMI

Condition:   Myocardial Infarction
Intervention:   Drug: Atorvastatin
Sponsor:   Penza State University
Completed

Cardiac Structure, Function, and Clinical Manifestations in MINOCA

Conditions:   Acute Coronary Syndrome;   Myocardial Infarction
Interventions:   Other: Integrative characterization of MINOCA patients;   Other: Characterization of MI patients with coronary obstruction
Sponsor:   Tomsk National Research Medical Center of the Russian Academy of Sciences
Recruiting

Effects of N-acetyl Cysteine During Percutaneous Coronary Intervention

Condition:   Coronary Artery Disease
Interventions:   Drug: N-acetyl cysteine;   Drug: Saline
Sponsor:   Suleyman Demirel University
Active, not recruiting

Technical Development of Cardiovascular Magnetic Resonance Imaging

Conditions:   Cardiomyopathy;   Congenital Heart Disease;   Cardiovascular Disease;   Cardiac Magnetic Resonance Imaging;   Acute Myocardial Infarction
Intervention:   Device: Siemens MRI scanner
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Suspended

Triple or Dual Antithrombotic Therapy After PCI (TRIDUAL-PCI) Coronary Intervention in Patients With Non-valvular Atrial Fibrillation. Real-world Italian Multicenter Registry (TRIDUAL-PCI)

Conditions:   Atrial Fibrillation;   Myocardial Infarction;   Anticoagulant-induced Bleeding;   Coronary Disease
Intervention:   Drug: Antithrombotic Agent
Sponsor:   Scientific Institute San Raffaele
Recruiting

Acute Coronary Syndrome and Care-Seeking Delay: A Web Based Behavioral Study

Conditions:   Acute Myocardial Infarction;   Heart Attack;   Acute Coronary Syndrome;   Unstable Angina
Intervention:  
Sponsors:   Yale University;   Ohio State University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

SP16 Inflammatory Response Inhibition Trial

Conditions:   Myocardial Infarction;   Inflammation
Intervention:   Drug: SP16
Sponsors:   Virginia Commonwealth University;   Serpin Pharma, LLC
Active, not recruiting

Local Thrombolytics Before Thrombectomy in STEMI

Condition:   Coronary Artery Disease
Interventions:   Drug: Urokinase;   Drug: Saline
Sponsor:   University of Roma La Sapienza
Enrolling by invitation

Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Patients With DIABETES Mellitus (OPTIMAL-DIABETES)

Conditions:   Diabetes Mellitus;   High Blood Pressure;   Cardiovascular Diseases;   Cognitive Impairment
Interventions:   Drug: Intensive Control of Systolic Blood Pressure (SBP);   Drug: Standard control of Systolic Blood Pressure (SBP)
Sponsors:   Hospital Israelita Albert Einstein;   Ministry of Health, Brazil
Recruiting

A Single Arm Trial With Resolute Onyx in ONE-Month DAPT for High-Bleeding Risk Patients Who Are Considered One-Month Clear (Onyx ONE Clear)

Condition:   Coronary Artery Disease
Intervention:   Combination Product: Device: Medtronic Resolute Onyx Zotarolimus-Eluting Coronary Stent System Treatment Followed by one-month DAPT
Sponsor:   Medtronic Vascular
Active, not recruiting

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention & Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Population Health Research Institute;   Janssen Research & Development, LLC
Active, not recruiting

Brilinta Clinical Experience Investigation

Condition:   Acute Coronary Syndrome, Old Myocardial Infarction
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Randomized Endo-Vein Graft Prospective

Condition:   Coronary Artery Bypass Grafting
Intervention:   Procedure: Vein Harvesting Procedures
Sponsor:   VA Office of Research and Development
Active, not recruiting

Mer-TK in Human Cardiac Cells

Conditions:   Myocardial Inflammation;   Myocardial Infarction
Intervention:   Other: Change in Soluble MER Concentration
Sponsor:   Ann & Robert H Lurie Children's Hospital of Chicago
Active, not recruiting

Major Outcomes With Personalized Dialysate TEMPerature

Conditions:   Kidney Diseases;   End-Stage Kidney Disease;   Hemodialysis
Intervention:   Other: Personalized Dialysate Temperature
Sponsors:   Lawson Health Research Institute;   Population Health Research Institute;   Ottawa Hospital Research Institute;   Dialysis Clinic, Inc.;   Cancer Care Ontario;   Institute for Clinical Evaluative Sciences;   The Kidney Foundation of Canada;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting

SGLT2 Inhibitor or Metformin as Standard Treatment of Early Stage Type 2 Diabetes

Condition:   Type 2 Diabetes
Interventions:   Drug: Metformin;   Drug: Dapagliflozin 10 MG
Sponsors:   Uppsala University;   Uppsala University Hospital;   Swedish Healthcare Regions;   Swedish National Board of Health and Welfare;   The Swedish National Diabetes Register
Recruiting

Effects of N-acetyl Cysteine During Primary Percutaneous Coronary Intervention

Condition:   Acute ST Segment Elevation Myocardial Infarction
Interventions:   Drug: NAC;   Drug: Saline
Sponsor:   Suleyman Demirel University
Active, not recruiting

Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The ECLIPSE Trial

Conditions:   Coronary Artery Disease;   Ischemic Heart Disease;   Non ST Segment Elevation Myocardial Infarction
Interventions:   Device: Orbital Atherectomy;   Device: Balloon
Sponsors:   Cardiovascular Systems Inc;   Cardiovascular Research Foundation, New York
Recruiting

The Cardiovascular Multi-dimensional Observational Investigation of the Use of PCSK9 Inhibitors (cvMOBIUS)

Condition:   ASCVD
Intervention:  
Sponsors:   Amgen;   Duke Clinical Research Institute
Recruiting

Partnering Physical and Emotional Fitness: Improving Cardiac Recovery With Training in Emotion Regulation

Conditions:   Cardiac Disease;   Myocardial Infarction
Intervention:   Other: RENEwS
Sponsor:   Case Western Reserve University
Completed

Inova Cardiogenic Shock Registry (INOVA SHOCK)

Condition:   Cardiogenic Shock
Intervention:   Procedure: Cardiogenic Shock team activation
Sponsor:   Inova Health Care Services
Recruiting

Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Biological: Apolipoprotein A-I [human] (apoA-I);   Other: Placebo
Sponsor:   CSL Behring
Active, not recruiting

Optimal Antithrombotic Therapy for ACS Patients Concomitant AF Undergoing New Generation DES Implantation

Conditions:   Acute Coronary Syndrome (ACS);   Non-valvular Atrial Fibrillation (NVAF)
Interventions:   Drug: Triple antithrombotic therapy;   Drug: Dual antithrombotc therapy
Sponsor:   The First Affiliated Hospital with Nanjing Medical University
Recruiting

Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?

Conditions:   Vitamin D Deficiency;   Cardiomyopathies;   Apoptosis;   Inflammation
Interventions:   Drug: Vitamin D;   Drug: Placebo
Sponsor:   Shahid Beheshti University of Medical Sciences
Completed

Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity

Conditions:   Overweight;   Obesity
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

Preventing Cardiac Complication of COVID-19 Disease With Early Acute Coronary Syndrome Therapy: A Randomised Controlled Trial.

Condition:   COVID-19
Interventions:   Drug: Aspirin 75mg;   Drug: Clopidogrel 75mg;   Drug: Rivaroxaban 2.5 MG;   Drug: Atorvastatin 40mg;   Drug: Omeprazole 20mg
Sponsor:   Imperial College London
Not yet recruiting

Prognosis of Patients With Acute Coronary Syndrome Complicated With Renal Insufficiency(PACS-RI)

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   Henan Institute of Cardiovascular Epidemiology
Completed

Biochemical and Electrocardiographic Signatures in the Detection of Exercise-induced Myocardial Ischemia

Conditions:   Coronary Artery Disease;   Angina, Stable;   Exercise Test;   Biological Markers;   SPECT
Intervention:  
Sponsor:   University Hospital, Basel, Switzerland
Active, not recruiting

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)

Condition:   Hypertension
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

SVS VQI TransCarotid Revascularization Surveillance Project

Condition:   Carotid Artery Disease
Interventions:   Procedure: Transcarotid artery revascularization;   Procedure: Carotid endarterectomy
Sponsor:   Society for Vascular Surgery Patient Safety Organization
Recruiting

Bioflow-DAPT Study

Condition:   Coronary Artery Disease
Intervention:   Device: Percutaneous coronary intervention
Sponsor:   Biotronik AG
Recruiting

Evaluating a New Echocardiography Imaging Procedure for Evaluating Heart Function

Conditions:   Ischemia;   Myocardial Infarction;   Ischemic Heart Disease
Intervention:  
Sponsors:   Yale University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

The Effect of Cardiac Educational Program on Level of Knowledge and Satisfaction Among Coronary Artery Disease Patients in North of Jordan

Condition:   Coronary Artery Disease
Intervention:   Other: cardiac educational program
Sponsor:   Jordan University of Science and Technology
Recruiting

Desmopressin for Reversal of Antiplatelet Drugs in Stroke Due to Haemorrhage

Condition:   Stroke, Acute
Interventions:   Drug: Desmopressin Injection;   Drug: Normal saline
Sponsors:   University of Nottingham;   National Institute for Health Research, United Kingdom
Recruiting

Evaluation of PET/MR in Patients Selected for Ablation Therapy

Condition:   Arrhythmias, Cardiac
Intervention:   Drug: 18F-TPP
Sponsor:   Massachusetts General Hospital
Recruiting

Cytisine Compared to Combination NRT in Relapsed Smokers

Conditions:   Smoking Cessation;   Coronary Artery Disease
Interventions:   Drug: Cytisine;   Drug: Nicoderm C-Q Transdermal Product;   Drug: Nicorette Lozenge Product
Sponsor:   Ottawa Heart Institute Research Corporation
Not yet recruiting

Randomized Trial of COBRA PzF Stenting to Reduce Duration of Triple Therapy

Conditions:   Angina, Stable;   Angina, Unstable;   Anticoagulants
Interventions:   Device: COBRA PzF;   Device: Drug Eluting Stent
Sponsor:   CeloNova BioSciences, Inc.
Recruiting

Pilot for a Community Pharmacy Service Model: Impact of a Pharmacist Monitored Patient Blood Pressure Readings

Condition:   Hypertension
Intervention:   Other: Incentivized Care
Sponsor:   Virginia Commonwealth University
Active, not recruiting

Meta-analysis of Fish Oil Supplementation and Cardiovascular Outcomes in Diabetes

Conditions:   Type2 Diabetes;   Heart Failure;   Myocardial Infarction;   Stroke;   Arrhythmia;   Cardiovascular Diseases
Intervention:   Dietary Supplement: fish oil supplement
Sponsors:   University of Toronto;   Diabetes and Nutrition Study Group (DNSG) of the European Association for the Study of Diabetes (EASD);   Canadian Institutes of Health Research (CIHR);   Diabetes Canada
Active, not recruiting

Relatively Healthy Male Veterans Observed Over Time to See What Types of Diseases Develop

Condition:   Healthy
Intervention:  
Sponsor:   VA Office of Research and Development
Active, not recruiting

Angio-based Fractional Flow Reserve to Predict Adverse Events After Stent Implantation

Conditions:   Prognosis;   Stents
Intervention:   Other: angio-based FFR estimation
Sponsor:   University Hospital of Ferrara
Active, not recruiting

Identification of Genes Expressed in Atherosclerotic Plaque

Condition:   Atherosclerosis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Elite Controller and ART-treated HIV+ Statin Versus ASA Treatment Intervention Study

Condition:   Human Immunodeficiency Virus
Interventions:   Drug: Aspirin;   Drug: Lipitor
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Completed

Joint Use of Electrocardiogram and Transthoracic Echocardiography in an Observational Study to Monitor Cardio-vascular Events in Patients Diagnosed With COVID-19

Conditions:   COVID-19;   Myocardial Injury;   Myocarditis
Intervention:   Diagnostic Test: Electrocardiogram and transthoracic echocardiography
Sponsor:   Groupe Hospitalier Pitie-Salpetriere
Recruiting

Evaluation of Hemodynamic Parameters Following Transjugular Intrahepatic Portosystemic Shunt (TIPS)

Condition:   Refractory Ascites
Interventions:   Procedure: Study - Transjugular Intrahepatic Portosystemic Shunt (TIPS);   Procedure: Control - Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Sponsors:   Medical College of Wisconsin;   Radiological Society of North America
Enrolling by invitation

Diagnosis of Pheochromocytoma

Conditions:   Pheochromocytoma;   Endocrine Disease;   Endocrine Diseases
Interventions:   Drug: ([18F]-DOPA);   Drug: [68Ga]-DOTATATE;   Drug: ([18F]-6F-DA)
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Post Market Surveillance of SeQuent Please Neo With Scoring Balloon

Condition:   Coronary Artery Disease (CAD)
Intervention:   Device: Drug Coated Balloon Angioplasty, Scoring Balloon Dilatation
Sponsors:   B. Braun Melsungen AG;   Klinikum Ernst von Bergmann Augenklinik Laserzentrum
Completed

A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Advanced Prostate Cancer and Cardiovascular Disease

Condition:   Prostate Cancer
Interventions:   Drug: Degarelix;   Drug: Leuprolide
Sponsors:   Ferring Pharmaceuticals;   Memorial Sloan Kettering Cancer Center;   Duke Clinical Research Institute
Active, not recruiting

Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in Europe

Conditions:   Coronary Artery Disease;   Myocardial Infarction;   Dilated Cardiomyopathy;   Implantable Defibrillator User
Intervention:  
Sponsor:   University Medical Center Goettingen
Completed

Efficacy of Blanketrol III and Arctic Sun in Cooling Non-shivering Humans

Condition:   Body Temperature Changes
Interventions:   Device: Blanketrol cooling device and water-perfused blankets;   Device: Blanketrol and Kool Kit;   Device: Arctic Sun
Sponsor:   University of Manitoba
Recruiting

Study of Major Cardiovascular Events in Patients With Nonvalvular Atrial Fibrillation Treated With Rivaroxaban

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

The GReek Study in the Effects of Colchicine in Covid-19 cOmplications Prevention

Condition:   Corona Virus Disease 19 (Covid 19)
Interventions:   Drug: Colchicine;   Drug: Standard treatment
Sponsor:   National and Kapodistrian University of Athens
Not yet recruiting

Implementing Precision Medicine Approaches to Guide Anti-platelet Selection

Conditions:   Acute Coronary Syndrome (ACS);   STEMI - ST Elevation Myocardial Infarction (MI);   NSTEMI - Non-ST Segment Elevation MI;   Unstable Angina (UA)
Intervention:   Genetic: CYP2C19 genotyping
Sponsor:   University of Southern California
Active, not recruiting

Quantitative Coronary Angiography Versus Intravascular Ultrasound GUIDancE for Drug-Eluting Stent Implantation

Conditions:   Coronary Disease;   Coronary Stenoses
Interventions:   Device: quantitative coronary angiography guided coronary intervention with sirolimus-eluting Orsiro stent;   Device: intravascular ultrasound guided coronary intervention with sirolimus-eluting Orsiro stent
Sponsors:   CHEOL WHAN LEE, M.D., Ph.D;   Biotronik SE & Co. KG
Recruiting

Prospective Registry of Acute Coronary Syndromes in Ferrara

Condition:   Acute Coronary Syndromes
Intervention:   Other: prospective collection of data and follow-up
Sponsor:   University Hospital of Ferrara
Recruiting

Optimal Timing of Transcatheter Aortic Valve Implantation and Percutaneous Coronary Intervention - The TAVI PCI Trial

Conditions:   Aortic Stenosis;   Coronary Artery Disease;   TAVI;   PCI
Interventions:   Procedure: PCI before TAVI;   Procedure: PCI after TAVI
Sponsor:   University of Zurich
Not yet recruiting

Registry on Left Main Coronary Artery Bifurcation Percutaneous Intervention

Conditions:   Coronary Arteriosclerosis;   Left Main Coronary Artery Disease
Intervention:   Procedure: PCI on left main
Sponsors:   G. d'Annunzio University;   Azienda Sanitaria Locale n. 2 - Lanciano Vasto Chieti;   Hospital Clínico Universitario de Valladolid;   VZW Cardiovascular Research Center Aalst;   Federico II University;   Fondazione Policlinico Universitario Agostino Gemelli IRCCS;   Clinica Mediterranea;   Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland;   San Raffaele University Hospital, Italy;   Instituto Dante Pazzanese de Cardiologia;   University Medical Centre Maribor;   Clinica Di Montevergine;   Clinical Hospital Centre Zagreb;   Clinical Centre of Serbia;   Chiba University;   Université Paris-Sud;   Hospital Universitario Reina Sofia de Cordoba;   Mount Sinai Hospital, New York;   Hospital Pablo Tobón Uribe;   Pauls Stradins Clinical University Hospital;   University Hospital Monastir, Tunis
Not yet recruiting

Pharmacodynamics and Pharmacokinetics of Aspirin Inhalation Powder With Non-Enteric-Coated Chewable Aspirin

Condition:   Platelet Aggregation Inhibitors
Intervention:   Drug: Aspirin
Sponsor:   Inova Health Care Services
Completed

A Genomic Approach for Clopidogrel in Caribbean Hispanics

Conditions:   Cardiovascular Disease (CVD);   Stroke;   Acute Coronary Syndrome;   Peripheral Arterial Disease;   Coronary Artery Disease;   Myocardial Infarction
Interventions:   Genetic: CYP2C19 test;   Diagnostic Test: P2RY12 assay
Sponsors:   University of Puerto Rico;   National Institute on Minority Health and Health Disparities (NIMHD);   Icahn School of Medicine at Mount Sinai
Recruiting

Stroke Imaging Package Study of Intracranial Atherosclerosis ( SIPS-ICAS )

Conditions:   Acute Ischemic Stroke AIS;   Intracranial Atherosclerosis ICAS
Intervention:   Drug: aggressive medical management
Sponsors:   Wei-Hai Xu;   Peking Union Medical College Hospital;   General Hospital of Chinese Armed Police Forces;   General Hospital of Shenyang Military Region;   Subei People's Hospital of Jiangsu Province;   Fujian Medical University Union Hospital;   Tangshan Gongren Hospital;   Third Affiliated Hospital, Sun Yat-Sen University;   Qingdao Municipal Hospital;   West China Hospital;   Shanghai Tong Ren Hospital;   Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine;   The First Affiliated Hospital of University of South China;   JiNing NO.1 People Hospital;   Tongji Hospital;   The University of HongKong-Shenzhen Hospital;   Beijing Anzhen Hospital;   Beijing Hospital;   Peking University International Hospital;   Beijing Tongren Hospital;   China-Japan Friendship Hospital;   Peking University First Hospital;   Beijing Friendship Hospital;   Beijing Chao Yang Hospital;   Qilu Hospital of Shandong University (Qingdao);   Shandong Provincial Hospital;   The Second Hospital of Hebei Medical University;   Hebei General Hospital;   First Affiliated Hospital of Zhejiang University;   China-Japan Union Hospital, Jilin University;   Zhejiang Provincial Tongde Hospital;   People's Hospital of Ningxia Hui Autonomous Region;   Taiyuan Central Hospital of Shanxi Medical University;   Hong Xinglong Central Hospital;   Changzhi People's Hospital;   Weihai Municipal Hospital;   The first hospital affiliated to AMU (Southwest Hospital);   Affiliated Taihe Hospital of Hubei University of Medicine;   Nanshi Hospital of Nanyang
Recruiting

Saxagliptin and Cardiac Structure and Function

Conditions:   Diabetes Mellitus, Non-Insulin-Dependent;   Heart Failure
Interventions:   Drug: Saxagliptin;   Drug: saxagliptin
Sponsor:   St. Michael's Hospital, Toronto
Completed

Sleep-disordered Breathing and Perioperative Atrial Fibrillation in Cardiac Surgery

Conditions:   Elective Coronary Artery Bypass Grafting (CABG) Surgery;   Coronary Artery Disease;   Sleep-disordered Breathing (SDB);   Atrial Fibrillation
Intervention:   Other: Stratification, no intervention
Sponsor:   Michael Arzt
Recruiting

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Conditions:   Cognitive Impairment, Mild;   Dementia;   Cardiovascular Diseases
Interventions:   Drug: Atorvastatin 40 Mg Oral Tablet;   Drug: Placebo oral tablet
Sponsors:   Duke University;   National Institute on Aging (NIA);   National Heart, Lung, and Blood Institute (NHLBI);   Wake Forest University Health Sciences
Not yet recruiting

Undiagnosed Sleep Apnea and Bypass OperaTion

Condition:   Sleep Apnea
Intervention:  
Sponsor:   National University, Singapore
Completed

HIV-HEART Aging Study (15 Year Follow up)

Conditions:   HIV Infections;   Coronary Disease;   Myocardial Infarction;   HIV Encephalopathy;   Aging;   Heart Failure;   Weight Gain
Intervention:  
Sponsor:   University Hospital, Essen
Not yet recruiting

A Clinical Trial to Confirm Safety & Effectiveness of the SYNERGY 4.50 mm and 5.00 mm Stent for Treatment of Atherosclerotic Lesion(s)

Conditions:   Atherosclerosis;   Heart Diseases, Coronary;   Coronary Artery Disease;   Cardiovascular Diseases
Intervention:   Device: SYNERGY 4.50 mm and 5.0 mm Coronary Stent System
Sponsor:   Boston Scientific Corporation
Recruiting

A Clinical Trial to Assess the SYNERGY 48 mm Stent System for the Treatment of Atherosclerotic Lesion(s)

Condition:   Coronary Artery Disease
Intervention:   Device: SYNERGY 48 mm
Sponsor:   Boston Scientific Corporation
Active, not recruiting

Intravascular Balloon Lithotripsy in Left Main Stem Percutaneous Coronary Intervention

Conditions:   Coronary Artery Calcification;   Left Main Coronary Artery Disease
Intervention:   Device: Left main stenting with intravascular lithotripsy
Sponsors:   St George's, University of London;   St George's University Hospitals NHS Foundation Trust;   Shockwave Medical, Inc.
Not yet recruiting

Aclidinium Bromide Post-Authorisation Safety Study to Evaluate the Risk of Cardiovascular Endpoints

Condition:   Pulmonary Disease, Chronic Obstructive
Interventions:   Drug: Aclidinium bromide;   Drug: Other COPD medication
Sponsors:   AstraZeneca;   RTI Health Solutions
Active, not recruiting

SELUTION SLR™ 014 In-stent Restenosis

Condition:   Coronary Restenosis
Interventions:   Device: SELUTION SLR™ DEB;   Device: Control
Sponsors:   M.A. Med Alliance S.A.;   Genae;   Baim Institute for Clinical Research
Not yet recruiting

Early Feasibility Study of the AccuCinch® Ventricular Repair System - The CorCinch-FMR Study

Conditions:   Heart Failure;   Mitral Valve Insufficiency;   Cardiomyopathies
Intervention:   Device: Mitral valve repair
Sponsor:   Ancora Heart, Inc.
Active, not recruiting

ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair.

Conditions:   Abdominal Aortic Aneurysm;   Surgery;   Arterial Disease
Interventions:   Drug: ACT guided heparinization;   Drug: 5 000 IU of heparin
Sponsors:   Dijklander Ziekenhuis;   ZonMw: The Netherlands Organisation for Health Research and Development;   VU University Medical Center;   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Recruiting

VitamIn and oXygen Interventions and Cardiovascular Events

Condition:   Postoperative Cardiac Complication
Interventions:   Drug: Oxygen;   Drug: Antioxidants
Sponsor:   University Hospital Bispebjerg and Frederiksberg
Completed

Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates

Conditions:   Cardiovascular Diseases;   End Stage Renal Disease;   Kidney Transplantation;   Dialysis Related Complication
Interventions:   Other: No screening;   Other: Regular Screening
Sponsors:   University of British Columbia;   University of Sydney
Recruiting

Repetitive Assessement of PRECISE-DAPT Score

Conditions:   Cardiovascular Diseases;   Interventional Cardiology
Intervention:   Diagnostic Test: Repetitive assessment of PRECISE-DAPT score
Sponsor:   University of Roma La Sapienza
Completed

A Randomized Non-inferiority Study of Low-dose and Standard-dose Ticagrelor After Intervention for Acute Coronary Syndrome

Conditions:   Acute Coronary Syndrome;   Coronary Stent Implantation
Interventions:   Drug: Ticagrelor 60mg;   Drug: Ticagrelor 90mg
Sponsors:   Shanghai Tong Ren Hospital;   Shanghai Jiao Tong University School of Medicine;   Fudan University
Recruiting

Addressing Sleep Apnea Post-Stroke/TIA

Conditions:   Ischemic Stroke;   Transient Ischemic Attack (TIA);   Obstructive Sleep Apnea
Intervention:   Other: ASAP Intervention Quality Improvement Protocol
Sponsor:   VA Office of Research and Development
Not yet recruiting

Effect Levosimendan Administration on Postoperative NT-proBNP in Cardiac Risk Patients

Condition:   Cardiovascular Risk Factor
Interventions:   Drug: Levosimendan;   Drug: Placebo
Sponsor:   Medical University of Vienna
Not yet recruiting

IDE Trial for Boston Scientific's Cryoballoon in the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Intervention:   Device: POLARx™ Cardiac Cryoablation System
Sponsor:   Boston Scientific Corporation
Not yet recruiting

Characterization of Cardiovascular Diseases and Risk Factors in Patients With Suspected SARS-CoV2/Covid-19 Infection

Conditions:   Cardiovascular Diseases;   Cardiovascular Risk Factor;   SARS
Intervention:   Diagnostic Test: Assessment of cardiovascular diseases and cardiovascular risk factors
Sponsor:   University Hospital, Essen
Recruiting

Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

Condition:   CAD
Interventions:   Device: MRI scan x 1 Healthy Volunteer;   Device: MRI scan x 2 Healthy Volunteer;   Device: MRI scan x 2 - CAD patients;   Device: MRI scan x 2- non CAD patients
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Empowerment and Mobile Technology in the Control of Cardiovascular Risk Factors in Patients With Ischemic Stroke

Conditions:   Ischemic Stroke;   Transient Ischemic Attack;   Atrial Fibrillation;   Hypertension;   Empowerment
Interventions:   Diagnostic Test: ECG monitoring for 3 weeks;   Other: Self-monitoring of BP and self-titration of antihypertensive medication
Sponsor:   Jukka Putaala
Recruiting

Online Trial Examining Validity and Reliability of the Shared Decision Making Process Survey

Conditions:   High Cholesterol;   High Blood Pressure;   Colorectal Cancer;   Breast Cancer;   Prostate Cancer
Intervention:  
Sponsors:   Massachusetts General Hospital;   Carol Cosenza, Center for Survey Research at University of Massachusetts, Boston
Not yet recruiting

Evaluation of VISITAG SURPOINT™ Module With External Processing Unit (EPU)

Condition:   Paroxysmal Atrial Fibrillation
Intervention:   Device: Catheter ablation with EPU
Sponsor:   Biosense Webster, Inc.
Recruiting

Effect of Smoking Reduction on Endothelial Glucocalyx and Vascular Function

Condition:   Smoking Cessation
Interventions:   Drug: Varenicline;   Drug: nicotine
Sponsor:   University of Athens
Active, not recruiting

A Nationwide Observational Study Looking at Effectiveness and Bleeding Complications of NOACs vs. VKA in Non-valvular Atrial Fibrillation Patients.

Condition:   Non-valvular Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Apixaban (Eliquis);   Drug: Dabigatran etexilate (Pradaxa);   Drug: Warfarin (Marevan)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Terminated

CRT-P or CRT-D in Dilated Cardiomyopathy

Condition:   Cardiomyopathy, Dilated, 3B
Interventions:   Device: CRT-D;   Device: CRT-P
Sponsor:   University Hospital Olomouc
Not yet recruiting

Coroflex ISAR 2000 Extended Registry (ISAR2000 Extended)

Condition:   Coronary Artery Disease (CAD)
Intervention:   Device: stenting with the Coroflex ISAR sirolimus-eluting stent
Sponsors:   B. Braun Melsungen AG;   Charite University, Berlin, Germany
Active, not recruiting

Active Surveillance Research Program for the Assessment of the Safety and the Effectiveness of Linagliptin

Condition:   Diabetes Mellitus, Type 2
Intervention:  
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Completed

Multicenter Study to Evaluate the Procedural Safety and Efficacy of ELCA in CAD

Condition:   Coronary Artery Disease
Intervention:   Device: Excimer Laser Coronary Atherectomy
Sponsors:   Spectranetics Corporation;   CBCC-VIBGYOR Research Pvt. Ltd.
Completed

Singapore Cardiac Longitudinal Outcomes Database

Conditions:   Coronary Artery Disease;   Congestive Heart Failure;   Atrial Fibrillation
Intervention:   Other: Data Collection
Sponsors:   National Heart Centre Singapore;   Ministry of Health, Singapore;   Changi General Hospital;   National University Hospital, Singapore;   Singapore General Hospital;   Tan Tock Seng Hospital;   Khoo Teck Puat Hospital;   SingHealth Polyclinics;   National Healthcare Group, Singapore;   Ng Teng Fong General Hospital;   Sengkang General Hospital;   National University Polyclinics;   Alexandra Hospital, Singapore
Active, not recruiting

Frailty in Elderly Patients Receiving Surgical or Percutaneous Procedures for Valvular Disorders

Conditions:   Age Problem;   Aortic Valve Disease;   Mitral Valve Disease
Intervention:   Other: frailty evaluation
Sponsors:   University Hospital of Ferrara;   Maria Cecilia Hospital
Recruiting

Prospective European Multicenter Study on Aortic Valve Replacement: (E-AVR Registry)

Conditions:   Aortic Valve Stenosis;   Valve Heart Stenosis
Intervention:   Procedure: Aortic valve replacement
Sponsors:   University of Parma;   University of Genova;   University Hospitals, Leicester;   University of Hamburg;   San Camillo Hospital, Rome;   University of Turin, Italy;   Centre Hospitalier Universitaire de Besancon;   University Hospital, Udine, Italy;   Hospital Clinic of Barcelona;   University of Lausanne Hospitals;   Robert Debré Hospital;   Paracelsus Medical University;   University of Campania "Luigi Vanvitelli";   University of Texas, Southwestern Medical Center at Dallas;   Clinique Pasteur;   Cardiocentro Ticino;   Universita di Verona
Recruiting

A Study to Investigate if Early Atrial Fibrillation (AF) Diagnosis Reduces Risk of Events Like Stroke in the Real-World

Condition:   Atrial Fibrillation
Interventions:   Device: Heart healthy Engagement Program with the Apple Watch Series 4 or later;   Device: Anti-Coagulation Adherence Module with the Apple Watch Series 5 or later
Sponsors:   Janssen Scientific Affairs, LLC;   Apple Inc.
Recruiting

Prevention Of Delirium in Elderly With Obstructive Sleep Apnea (PODESA)

Condition:   Sleep Apnea
Intervention:   Other: CPAP treatment
Sponsor:   University Health Network, Toronto
Active, not recruiting

Sleep Apnea and Atrial Fibrillation Recurrence

Conditions:   Sleep Apnea Syndrome;   Atrial Fibrillation
Intervention:   Other: Intervention group
Sponsor:   Assistance Publique - Hôpitaux de Paris
Suspended

Rivaroxaban and Vitamin K Antagonists for the Anticoagulation for the Implantation of Vena Cava Filters

Condition:   Venous Thromboembolism
Interventions:   Drug: Rivaroxaban;   Drug: Warfarin;   Drug: Nadroparin
Sponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Sir Run Run Shaw Hospital;   Huadong Hospital;   Shanghai Zhongshan Hospital;   Shanghai 5th People's Hospital;   Yantai Yuhuangding Hospital;   Anhui Provincial Hospital
Not yet recruiting

Study to Develop a Prediction Model to Understand the Effect of Low-dose Aspirin on Cancer That Develops in the Colon and/or the Rectum, Diseases That Affects the Heart or Blood Vessels and Safety Outcomes in European Countries. The Study is Also Called PEACOS Model EU

Conditions:   Colorectal Cancer;   Cardiovascular Disease;   Bleeding
Intervention:   Drug: Acetylsalicylic Acid (Aspirin, BAYE4465)
Sponsor:   Bayer
Active, not recruiting

Coroflex ISAR NEO "All Comers" Post Market Clinical Follow-up (PMCF)

Condition:   Coronary Artery Disease
Intervention:   Device: Coroflex® ISAR NEO coronary stent system
Sponsor:   B. Braun Melsungen AG
Recruiting

Identification of High-Risk Patients at Admission to an Emergency Department by Non-Invasive Hemodynamics

Conditions:   Emergency Department Triage;   Non-invasive Hemodynamic
Intervention:   Device: Finapres Nova
Sponsors:   University Hospital Bispebjerg and Frederiksberg;   Doctor Sofus Carl Emil Friis and Mrs Olga Doris Friss' Fund
Recruiting

Study to Gain Insights in Treatment Patterns and Outcomes in Patients With Atherosclerosis Prescribed to Xarelto in Combination With Acetylsalicylic Acid

Condition:   Atherosclerosis
Interventions:   Drug: Rivaroxaban (BAY59-7939, Xarelto);   Drug: Acetylsalicylic acid
Sponsors:   Bayer;   Janssen, LP
Recruiting

ACURATE Neo™ AS Aortic Bioprosthesis for Implantation Using the ACURATE neoTM AS TF Transfemoral Delivery System in Patients With Severe Aortic Stenosis

Condition:   Aortic Stenosis
Intervention:   Device: Transcatheter aortic valve replacement
Sponsor:   Symetis SA
Active, not recruiting

Atrial Cardiomyopathy in Patients With Stroke of Undetected Mechanism

Condition:   Stroke
Intervention:  
Sponsors:   University Hospital Bispebjerg and Frederiksberg;   Rigshospitalet, Denmark;   Lundbeck Foundation
Recruiting

Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement

Conditions:   Pulmonary Embolism;   Venous Thrombosis
Interventions:   Drug: Enteric Coated Aspirin;   Drug: Warfarin;   Drug: Rivaroxaban
Sponsors:   Medical University of South Carolina;   Patient-Centered Outcomes Research Institute;   University of Maryland, Baltimore;   Brigham and Women's Hospital;   Northwestern University
Recruiting

Effect of Pre-op NRT on Peri-operative Complications and Long-term Abstinence: A Pilot Trial in Patients Undergoing CABG Surgery

Condition:   Smoking Cessation
Intervention:   Drug: Nicoderm Patch
Sponsor:   Ottawa Heart Institute Research Corporation
Active, not recruiting

"Post-acute Pickwick Study" (Postacute-Pick-2020)

Conditions:   Acute on Chronic Hypercapnic Respiratory Failure;   Obesity Hypoventilation Syndrome (OHS)
Interventions:   Procedure: "Lifestyle modifications" group (Control);   Procedure: Automatic NIV;   Procedure: CPAP treatment group;   Procedure: NIV treatment groups
Sponsor:   Juan F. Masa
Not yet recruiting

Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome

Conditions:   Brain Infarction;   Ischemic Stroke;   Thrombosis;   Foramen Ovale, Patent
Intervention:  
Sponsors:   SECRETO Study Consortium;   Finnish Medical Foundation;   Helsinki University Central Hospital;   Academy of Finland;   Göteborg University
Recruiting

Respiratory Virus Infections in Acutely Hospitalized Adult Patients With Pulmonary and Extrapulmonary Complications

Conditions:   Respiratory Virus Infection;   Stroke;   Lung Disease;   Acute Coronary Syndrome
Intervention:   Diagnostic Test: Respiratory virus testing
Sponsor:   The University of Hong Kong
Recruiting

Statins for Venous Event Reduction in Patients With Venous Thromboembolism

Conditions:   Venous Thromboembolism;   Blood Clot;   Post Thrombotic Syndrome
Interventions:   Drug: Rosuvastatin Calcium;   Drug: Placebo Oral Tablet
Sponsor:   Ottawa Hospital Research Institute
Not yet recruiting

Platelet REACtivity According to TICagrelor Dose After Transcatheter AorticValve Implantation

Condition:   Symptomatic Aortic Stenosis
Intervention:   Drug: Ticagrelor 60mg
Sponsor:   Andres Iñiguez Romo
Not yet recruiting

10-year Risk Prediction Models of Complications and Mortality of DM in Hong Kong

Conditions:   Diabetes Mellitus;   Cardiovascular Diseases;   Mortality;   Primary Health Care
Intervention:  
Sponsor:   The University of Hong Kong
Completed

The Broken Heart Study II (BHS-II)

Condition:   Takotsubo Cardiomyopathy
Intervention:   Other: Stress reactivity test
Sponsors:   The Miriam Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

The Comparison of Strategies to PREPARE Severely CALCified Coronary Lesions Trial (PREPARE-CALC)

Condition:   Coronary Atherosclerosis Due to Severely Calcified Coronary Lesion
Interventions:   Device: Rotational Atherectomy;   Device: Cutting/Scoring Balloon
Sponsor:   Segeberger Kliniken GmbH
Completed

Serum Biomarkers for Aortic Valve Stenosis

Conditions:   Calcific Aortic Valve Disease;   Aortic Valve Stenosis;   Aortic Valve, Calcification of
Interventions:   Diagnostic Test: Echocardiography;   Diagnostic Test: Computerized Tomography Aortic Valve Calcium Score;   Other: Untargeted LC/MS and LC-MS/MS;   Other: Targeted LC/MS and LC-MS/MS;   Diagnostic Test: multiplex ELISA
Sponsors:   National and Kapodistrian University of Athens;   Biomedical Research Foundation of the Academy of Athens;   University of Oxford
Recruiting

Rivaroxaban for the Prevention of Deep Vein Thrombosis in Patients With Left Iliac Vein Compression - The PLICTS Study

Condition:   May-Thurner Syndrome
Interventions:   Drug: Rivaroxaban;   Drug: Warfarin;   Drug: Nadroparin
Sponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Sir Run Run Shaw Hospital;   Huadong Hospital;   Shanghai Zhongshan Hospital;   Shanghai 5th People's Hospital;   Yantai Yuhuangding Hospital;   Anhui Provincial Hospital
Not yet recruiting

Bone Microarchitecture in the Transplant Patient

Condition:   Organ Transplant
Intervention:   Procedure: Tibial cortical density evaluation
Sponsor:   Hospices Civils de Lyon
Active, not recruiting

Helicobacter Eradication Aspirin Trial

Conditions:   Gastrointestinal Ulcer Haemorrhage;   Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Interventions:   Drug: Lansoprazole 30mg, Clarithromycin 500mg, Metronidazole 400mg;   Drug: Placebo lansoprazole 30mg, clarithromycin 500mg, metronidazole 400mg
Sponsors:   University of Nottingham;   Nottingham University Hospitals NHS Trust;   University of Southampton;   University of Durham;   University of Birmingham;   University of Oxford;   Queen's University, Belfast
Active, not recruiting

SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Interventions:   Device: Symplicity Spyral™ multi-electrode renal denervation system;   Procedure: Sham Procedure
Sponsor:   Medtronic Vascular
Active, not recruiting

Strategies for the Management of Atrial Fibrillation in patiEnts Receiving HemoDialysis

Conditions:   Atrial Fibrillation;   End Stage Renal Failure on Dialysis
Interventions:   Drug: Warfarin;   Drug: Apixaban;   Other: No oral anticoagulation
Sponsors:   St. Michael's Hospital, Toronto;   Canadian Institutes of Health Research (CIHR)
Recruiting

SPYRAL DYSTAL Clinical Study

Conditions:   Hypertension;   Vascular Diseases;   Cardiovascular Diseases
Intervention:   Device: Renal Denervation (Symplicity Spyral™)
Sponsor:   Medtronic Vascular
Recruiting

RescueTEE for In-hospital Cardiac Arrest (ReTEECA Trial)

Conditions:   Echocardiography, Transesophageal;   In-hospital Cardiac Arrest;   Cardiac Arrest;   Cardiopulmonary Arrest With Successful Resuscitation;   ACLS;   Image Guided ACLS
Intervention:   Diagnostic Test: Tranesophageal Echocardiography
Sponsor:   University of Pennsylvania
Not yet recruiting

Anemia Studies in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat in Non-Dialysis Subjects Evaluating Hemoglobin (Hgb) and Quality of Life (ASCEND-NHQ)

Condition:   Anaemia
Interventions:   Drug: Daprodustat (GSK1278863);   Drug: Placebo;   Drug: Iron therapy
Sponsor:   GlaxoSmithKline
Active, not recruiting

Efficacy and Safety of Allogeneic Mesenchymal Precursor Cells (Rexlemestrocel-L) for the Treatment of Heart Failure.

Condition:   Chronic Heart Failure
Interventions:   Biological: Allogeneic Mesenchymal Precursor Cells (MPC);   Other: Sham Comparator
Sponsor:   Mesoblast, Inc.
Active, not recruiting

A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel

Conditions:   Acute Ischemic Stroke;   Transient Ischemic Attack (TIA)
Interventions:   Drug: BMS-986177;   Other: Placebo;   Drug: Clopidogrel;   Drug: Aspirin
Sponsors:   Bristol-Myers Squibb;   Janssen, LP
Recruiting

ACE Inhibitors or ARBs Discontinuation in Context of SARS-CoV-2 Pandemia

Condition:   History of Cardiovascular Disease Treated With RAS Blockers and With SARS-CoV-2 Infection
Interventions:   Drug: 1: discontinuation of RAS blocker therapy;   Drug: 2: continuation of RAS blocker therapy
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Groupe Hospitalier Pitié-Salpêtrière
Not yet recruiting

Evaluation of the Potential Impact of Computerized Antimicrobial Stewardship

Conditions:   Antimicrobial Stewardship;   Cardiovascular Surgeries;   Computerized Decision Support System;   Coronary Artery Disease;   Valve Heart Disease
Intervention:   Other: Computer based Antimicrobial stewardship (AMS) intervention system
Sponsor:   China National Center for Cardiovascular Diseases
Not yet recruiting

A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

Epidural Anesthesia Within an Enhanced Recovery Pathway in Reducing Pain in Patients Undergoing Gynecologic Surgery

Conditions:   Intraoperative Complication;   Malignant Female Reproductive System Neoplasm;   Pain
Interventions:   Drug: Epidural analgesia;   Other: Intraoperative Complication Management and Prevention;   Procedure: Pain Therapy
Sponsor:   University of Wisconsin, Madison
Suspended

Campath, Calcineurin Inhibitor Reduction and Chronic Allograft Nephropathy

Condition:   Kidney Transplantation
Interventions:   Drug: Alemtuzumab;   Drug: Basiliximab;   Drug: Sirolimus;   Drug: Tacrolimus
Sponsors:   University of Oxford;   National Health Service, United Kingdom;   Pfizer;   Novartis
Completed

Low Voltage-Directed Catheter Ablation for Atrial Fibrillation

Condition:   Atrial Fibrillation - Symptomatic
Intervention:   Procedure: Radiofrequency ablation
Sponsors:   Ohad Ziv;   Biosense Webster, Inc.
Recruiting

Efficacy of a High-intensity Physical Activity Program on Renal Function in High Risk Patients With Type 2 Diabetes

Conditions:   Type2 Diabetes;   Diabetic Kidney Disease
Interventions:   Other: HIPA;   Other: Counseling PA
Sponsors:   Poitiers University Hospital;   University Hospital, Bordeaux;   University Hospital, Clermont-Ferrand;   Centre Hospitalier Universitaire Dijon;   Centre Hospitalier Universitaire de Besancon;   Hopital Lariboisière;   Bichat Hospital;   Centre Hospitalier Sud Francilien;   University Hospital, Lille;   Centre Hospitalier Universitaire de Nice;   University Hospital, Caen;   University Hospital, Toulouse;   University Hospital, Tours;   Nantes University Hospital;   Groupe Hospitalier Pitie-Salpetriere;   Hospices Civils de Lyon;   University Hospital, Montpellier;   University Hospital, Strasbourg;   Central Hospital, Nancy, France;   HOSPITAL, CHARTRES;   University of Liege
Recruiting

The Safety and Efficacy of Istaroxime for Pre-Cardiogenic Shock

Condition:   Cardiogenic Shock
Interventions:   Drug: Istaroxime;   Drug: Placebo
Sponsors:   Windtree Therapeutics;   Momentum Research, Inc.
Not yet recruiting

Levosimendan for Veno-arterial ECMO Weaning

Conditions:   Cardiogenic Shock;   Refractory Shock
Interventions:   Other: Data collection;   Other: Data analysis
Sponsor:   Hospices Civils de Lyon
Completed

Low Dose of Hydrocortisone and Fludrocortisone in Adult Cardiogenic Shock.

Condition:   Cardiogenic Shock
Interventions:   Combination Product: Hydrocortisone + Flucortac;   Other: Placebo
Sponsor:   CMC Ambroise Paré
Recruiting

Tenecteplase in Wake-up Ischaemic Stroke Trial

Conditions:   Ischemic Stroke;   Stroke, Acute
Interventions:   Drug: Tenecteplase;   Other: Control
Sponsors:   University Hospital of North Norway;   UiT The Arctic University of Norway;   The Royal Norwegian Ministry of Health;   Norwegian Health Association
Recruiting

A Study to Evaluate the Pharmacokinetics, Safety, and Antiviral Activity of JNJ-63623872 in Combination With Oseltamivir in Adult, and Elderly Hospitalized Participants With Influenza A Infection

Condition:   Influenza A Virus
Interventions:   Drug: JNJ-63623872;   Drug: Placebo;   Drug: Oseltamivir
Sponsor:   Janssen Research & Development, LLC
Completed

Improving Diabetes Outcomes for People With Severe Mental Illness (SMI)

Conditions:   Diabetes Mellitus, Type 2;   Severe Mental Disorder
Intervention:  
Sponsors:   University of York;   University of Leeds;   University of Southampton
Completed

A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunction

Conditions:   Hypertension, Pulmonary;   Ventricular Dysfunction, Left
Interventions:   Drug: Riociguat (Adempas, BAY63-2521);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Post-Surgery Extracorporeal Life Support

Conditions:   Cardiogenic Shock;   Extracorporeal Life Support;   Extracorporeal Membrane Oxygenation Complication;   Post Cardiac Arrest Syndrome;   Post-cardiac Surgery
Intervention:   Procedure: ECLS
Sponsors:   University of Florence;   Sandro Gelsomino;   Edvin Prifti;   Francesco Cabrucci;   Marco Bugetti;   Orlando Parise;   Aleksander Dokollari
Recruiting

Cardiogenic Shock Integrated PHenotyping for Event Reduction

Condition:   Heart Failure
Intervention:   Diagnostic Test: ELISA
Sponsor:   Niguarda Hospital
Recruiting

Nutritional Evaluation - NuEva Study

Condition:   Nutritional Evaluation
Intervention:   Dietary Supplement: menu plans
Sponsor:   University of Jena
Active, not recruiting

Identifying Most Effective Treatment Strategies to Control Arterial Hypertension in Sub-Saharan Africa

Condition:   Arterial Hypertension
Interventions:   Other: dual combination;   Other: triple combination;   Other: Standard of care
Sponsors:   University Hospital, Basel, Switzerland;   Swiss National Fund for Scientific Research
Recruiting

Safety and Efficacy Study of Lotus Valve for Transcatheter Aortic Valve Replacement

Condition:   Aortic Stenosis
Interventions:   Device: Lotus Valve System;   Device: CoreValve/Evolut R Transcatheter Aortic Valve Replacement System;   Device: LOTUS Edge Valve System
Sponsor:   Boston Scientific Corporation
Recruiting

Comparison of Abdominal Aortic Aneurysm Growth in Adult Smoking Patients Who Either Switch to IQOS, Continue Smoking, or Quit Smoking.

Conditions:   Smoking;   Abdominal Aortic Aneurysm;   IQOS Use
Interventions:   Other: IQOS;   Other: Cigarette;   Other: Smoking Cessation
Sponsor:   Philip Morris Products S.A.
Recruiting

Complex Large-bore Radial Percutaneous Coronary Intervention (PCI) Trial

Condition:   Complex Coronary Lesions
Interventions:   Procedure: radial artery access for complex PCI;   Procedure: femoral artery access for complex PCI
Sponsors:   Maatschap Cardiologie Zwolle;   Terumo Europe N.V.
Active, not recruiting

CCM Italian Registry

Condition:   Heart Failure
Intervention:   Device: CCM device implantation
Sponsors:   S. Andrea Hospital;   Ospedale Umberto I di Torino;   A.O.U. Città della Salute e della Scienza - Molinette Hospital;   Ospedale Cardinal Massaia;   Azienda Ospedaliero Universitaria Maggiore della Carita;   Azienda Ospedaliera S. Maria della Misericordia;   IRCCS Multimedica;   San Giovanni di Dio Hospital;   Monaldi Hospital;   Ospedale Miulli, Acquaviva delle Fonti;   Ospedale San Bortolo di Vicenza;   The Mediterranean Institute for Transplantation and Advanced Specialized Therapies;   ASST Fatebenefratelli Sacco;   Ospedale Policlinico San Martino;   Azienda Ospedaliera Bolognini di Seriate Bergamo;   Federico II University;   Ospedale Santa Croce-Carle Cuneo;   Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria;   Martini Hospital, Turin, Italy;   Ospedale di Ariano Irpino;   Ospedale di Borgomanero;   ASL Verbano-Cusio-Ossola;   Policlinico Hospital;   Azienda Ospedaliero Universitaria di Cagliari;   Fatebenefratelli Hospital;   Centro Cuore Morgagni, Pedara;   Santa Maria delle Grazie, Pozzuoli;   Ospedale di Gorizia;   ASP Enna;   Ospedale Garibaldi, Catania;   Ospedali Riuniti Anzio-Nettuno;   Ospedale Fracastoro, Soave San Bonifacio;   Ospedale Magalini, Villafranca;   Casa di Cura Pierangeli, Pescara
Recruiting

Metformin in the Diastolic Dysfunction of Metabolic Syndrome

Conditions:   Metabolic Syndrome X;   Diastolic Dysfunction;   Insulin Resistance
Interventions:   Behavioral: Lifestyle Counseling;   Drug: Metformin
Sponsors:   Universidade do Porto;   Centro Hospitalar de Vila Nova de Gaia/Espinho;   Merck Serono International SA
Completed

Postmastecomy Internal Mammary Nodal Irradiation for High-risk Breast Cancer Patients

Condition:   Breast Cancer
Interventions:   Radiation: internal mammary nodal irradiation;   Radiation: no internal mammary nodal irradiation
Sponsors:   Chinese Academy of Medical Sciences;   Hebei Medical University Fourth Hospital;   Shanghai Zhongshan Hospital;   Zhejiang Cancer Hospital;   Beijing Hospital;   Liaoning Tumor Hospital & Institute;   Jilin Provincial Tumor Hospital;   Shanxi Province Cancer Hospital;   Tangshan People's Hospital;   China-Japan Union Hospital, Jilin University;   First Hospital of Jilin University;   West China Hospital;   Peking Union Medical College Hospital;   Anyang Tumor Hospital;   Guizhou people's Hospital;   Henan Cancer Hospital;   Wuhan University;   Beijing Cancer Hospital;   Fudan University;   TAIZHOU HOSPITAL OF ZHEJIANG PROVINCE;   Fourth Military Medical University;   Shanxi Dayi Hospital;   First Affiliated Hospital Xi'an Jiaotong University;   Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University;   Fuwai Hospital of Chinese Academy of Medical Sciences
Recruiting

CHANGE Neo™ TA Registry With ACURATE Neo™ Aortic Bioprosthesis and ACURATE Neo™ TA Transapical Delivery System

Condition:   Aortic Stenosis
Intervention:   Device: ACURATE neo™ Aortic Bioprosthesis
Sponsor:   Symetis SA
Active, not recruiting

Robot-assisted Thoraco-laparoscopic Esophagectomy Versus Open Transthoracic Esophagectomy

Conditions:   Esophageal Carcinoma;   Esophageal Cancer
Intervention:   Procedure: Esophagectomy
Sponsor:   UMC Utrecht
Completed

Randomized Controlled Trial Between Auto-titration and Manual Titration of Non-invasive Ventilation in Obesity Hypoventilation Syndrome

Conditions:   Chronic Hypercapnic Respiratory Failure;   Obesity Hypoventilation Syndrome
Interventions:   Device: Manual Non invasive ventilation titration;   Device: Automatic Non invasive ventilation titration
Sponsor:   Sociedad Española de Neumología y Cirugía Torácica
Recruiting

A Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Administration of the Fixed-Dose Combination of Pertuzumab and Trastuzumab in Combination With Chemotherapy in Participants With HER2-Positive Early Breast Cancer

Condition:   Early Breast Cancer
Interventions:   Drug: Cyclophosphamide;   Drug: Doxorubicin;   Drug: Docetaxel;   Drug: Paclitaxel;   Drug: Pertuzumab IV;   Drug: FDC of Pertuzumab and Trastuzumab SC;   Drug: Trastuzumab IV;   Drug: Trastuzumab SC;   Procedure: Surgery;   Radiation: Post-operative Radiotherapy;   Drug: Hormone Therapy
Sponsor:   Hoffmann-La Roche
Active, not recruiting

Smartphone Electrocardiogram for Recording Atrial Fibrillation After a Cerebral Ischemic Event

Conditions:   Stroke;   Atrial Fibrillation
Intervention:   Device: Smartphone ECG
Sponsors:   Sarawak Heart Centre;   Ministry of Health, Malaysia
Recruiting

The Morehouse-Emory Cardiovascular Center for Health Equity Study: Clinical Intervention Project

Condition:   Cardiovascular Diseases
Interventions:   Behavioral: Health360x;   Behavioral: Health Coach
Sponsors:   Emory University;   American Heart Association
Completed

MitraClip EXPAND G4 Study

Conditions:   Mitral Valve Regurgitation;   Mitral Regurgitation
Intervention:   Device: MitraClip G4 System
Sponsors:   Abbott Medical Devices;   Abbott
Recruiting

European Prevention of Alzheimer's Dementia (EPAD) Longitudinal Cohort Study (LCS)

Condition:   Alzheimer's Dementia
Intervention:  
Sponsors:   University of Edinburgh;   Innovative Medicines Initiative
Terminated