Diabetes and Heart Disease

Clinical Trial Finder

Many patients with type 2 diabetes are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Type 2 Diabetes Mellitus Prevention Ukraine

Condition:   Evaluation of Lifestyle Modification for the Prevention of Type 2 Diabetes
Intervention:   Other: Lifestyle modification
Sponsor:   Komisarenko Institute of Endocrinology and Metobolism
Active, not recruiting

Novel Biomarker for Development of T2D

Condition:   Diabetes Type II
Intervention:  
Sponsors:   Duke University;   Children's Miracle Network;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Elucidating the Mechanism of Remission of Type 2 Diabetes in Morbid Obese Patients After Bariatric Surgery

Conditions:   Morbid Obesity;   Type2 Diabetes
Intervention:   Procedure: Laparoscopic Sleeve Gastrectomy
Sponsors:   Dasman Diabetes Institute;   Kuwait University
Active, not recruiting

Resolution of Type 2 Diabetes Mellitus: Intensive vs. Conventional Glycaemic Control After Obesity Surgery

Conditions:   Type 2 Diabetes Mellitus;   Obesity
Intervention:   Drug: Insulin
Sponsor:   Imperial College London
Completed

Decreasing Stress in Type 2 Diabetes

Conditions:   Stress;   Diabetes Mellitus, Type 2
Interventions:   Behavioral: Mindfulness Based Stress Reduction;   Behavioral: Stress Management Education
Sponsors:   Milton S. Hershey Medical Center;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   National Institutes of Health (NIH);   Penn State University;   Rowan University;   West Chester University of Pennsylvania
Not yet recruiting

Adipose Tissue Expandability and Type 2 Diabetes

Condition:   Type2 Diabetes Mellitus
Intervention:  
Sponsor:   Charles University, Czech Republic
Completed

Evaluation of Intra-Abdominal Fat Extraction Using HydraSolve T2D™ in Obese Subjects With Type 2 Diabetes

Conditions:   Diabetes Mellitus, Type 2;   Insulin Resistance
Intervention:   Device: HydraSolve T2D™
Sponsor:   Medality Medical
Recruiting

Effects of PDE-5 Inhibition on Postprandial Hyperglycemia in Type 2 Diabetes

Condition:   Type 2 Diabetes
Intervention:   Drug: Tadalafil
Sponsor:   Vastra Gotaland Region
Terminated

Early Intermittent Intensive Insulin Therapy as an Effective Treatment of Type 2 Diabetes (RESET-IT Main Trial)

Condition:   Type 2 Diabetes
Interventions:   Drug: Metformin alone;   Drug: Metformin + Intermittent Insulin Therapy
Sponsors:   Mount Sinai Hospital, Canada;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting

Preserving Beta-cell Function in Type 2 Diabetes With Exenatide and Insulin (PREVAIL)

Condition:   Type 2 Diabetes
Interventions:   Drug: Basal insulin and exenatide;   Drug: Basal insulin only;   Drug: Basal insulin and bolus insulin
Sponsors:   Mount Sinai Hospital, Canada;   Canadian Institutes of Health Research (CIHR);   University of Toronto
Recruiting

Effect of Dulaglutide on Liver Fat in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

Conditions:   Non Alcoholic Fatty Liver Disease;   Type2 Diabetes Mellitus
Intervention:   Drug: Dulaglutide
Sponsor:   Medanta, The Medicity, India
Completed

VERIFY:A Study to Compare Combination Regimen With Vildagliptin & Metformin Versus Metformin in Treatment-naïve Patients With Type 2 Diabetes Mellitus

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Placebo of vildagliptin;   Drug: vildagliptin;   Drug: Metformin
Sponsor:   Novartis Pharmaceuticals
Completed

Safety and Efficacy Study of Exenatide Once Weekly in Adolescents With Type 2 Diabetes

Condition:   Children and Adolescent With Type 2 Diabetes
Interventions:   Drug: Exenatide Once Weekly;   Drug: Placebo
Sponsor:   AstraZeneca
Active, not recruiting

Effects of BKR-017 on Insulin Resistance in Type 2 Diabetes Patients

Condition:   Type 2 Diabetes
Intervention:   Dietary Supplement: BKR-017
Sponsor:   BioKier Inc.
Not yet recruiting

Precision Nutrition Counseling in Type 2 Diabetes Patients

Condition:   Type 2 Diabetes
Interventions:   Behavioral: Diet education based on CGMS data;   Behavioral: Conventional diet education
Sponsors:   Seoul National University Hospital;   ChunLab
Recruiting

Metabolic Control Before and After Supplementation With Lactobacillus Reuteri DSM 17938 in Type 2 Diabetes Patients

Conditions:   Type 2 Diabetes;   Insulin Resistance
Intervention:   Dietary Supplement: Lactobacillus reuteri DSM 17938
Sponsor:   Vastra Gotaland Region
Completed

A Study of Tirzepatide (LY3298176) Compared to Dulaglutide in Participants With Type 2 Diabetes

Condition:   Type 2 Diabetes
Interventions:   Drug: Tirzepatide;   Drug: Dulaglutide
Sponsor:   Eli Lilly and Company
Recruiting

A Study of Insulin Glargine (LY2963016) in Adult Participants With Type 2 Diabetes in India

Condition:   Type 2 Diabetes Mellitus
Intervention:   Drug: Insulin Glargine
Sponsor:   Eli Lilly and Company
Recruiting

A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes on Metformin With or Without Sulfonylurea (SURPASS-AP-Combo)

Condition:   Type 2 Diabetes
Interventions:   Drug: Tirzepatide;   Drug: Insulin Glargine
Sponsor:   Eli Lilly and Company
Recruiting

A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Tirzepatide;   Drug: Dulaglutide
Sponsor:   Eli Lilly and Company
Not yet recruiting

The Clinical Study of the Effect of Highland Barley Diet on Blood Glucose in Patients With Type 2 Diabetes Mellitus

Condition:   Type 2 Diabetes Mellitus
Interventions:   Dietary Supplement: Highland Barley Diet;   Dietary Supplement: ADA diet
Sponsor:   Xuefeng Yu
Recruiting

A Psychological-behavioral Intervention to Increase Activity in Type 2 Diabetes

Condition:   Type 2 Diabetes Mellitus
Interventions:   Behavioral: Positive Psychology + Motivational Interviewing;   Behavioral: Diabetes Education
Sponsor:   Massachusetts General Hospital
Completed

A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes

Condition:   Type 2 Diabetes
Interventions:   Drug: Tirzepatide;   Drug: Semaglutide
Sponsor:   Eli Lilly and Company
Recruiting

A Study of LY900014 Compared to Insulin Lispro (Humalog) in Adults With Type 2 Diabetes

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: LY900014;   Drug: Insulin Lispro;   Drug: Insulin Glargine;   Drug: Insulin Degludec
Sponsor:   Eli Lilly and Company
Recruiting

A Long-term Safety Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes

Condition:   Type 2 Diabetes Mellitus
Intervention:   Drug: Tirzepatide
Sponsor:   Eli Lilly and Company
Active, not recruiting

Study to Assess the Efficacy of Liraglutide in Patients With Type 2 Diabetes Mellitus

Condition:   Type 2 Diabetes
Interventions:   Drug: liraglutide;   Drug: placebo
Sponsors:   Lecube, Albert, M.D.;   Dynamic Solutions;   Novo Nordisk A/S
Completed

Prolonged Fasting on Glucose Metabolism and Hormonal Regulation in Healthy, Obese and Subjects With Type 2 Diabetes

Conditions:   Healthy;   Obesity;   Type 2 Diabetes Mellitus;   Type 1 Diabetes
Interventions:   Behavioral: 12h fasting;   Behavioral: 36h fasting
Sponsor:   Medical University of Graz
Recruiting

Glycemic Control and Endothelial Function in Patients With Type 2 Diabetes

Condition:   Type 2 Diabetes Mellitus
Intervention:   Diagnostic Test: serotonin
Sponsor:   Karolinska Institutet
Completed

A Study of Dulaglutide (LY2189265) in Children and Adolescents With Type 2 Diabetes

Condition:   Type 2 Diabetes
Interventions:   Drug: Dulaglutide;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Recruiting

A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Not Controlled With Diet and Exercise Alone

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Tirzepatide;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Active, not recruiting

Motivational Interviewing in the Control of Arterial Hypertension and Type 2 Diabetes Mellitus

Conditions:   Type 2 Diabetes Mellitus;   Systemic Arterial Hypertension
Interventions:   Behavioral: Motivational interviewing;   Behavioral: Nursing Consultation
Sponsor:   Hospital Nossa Senhora da Conceicao
Active, not recruiting

A Study of Tirzepatide (LY3298176) Once a Week Versus Insulin Glargine Once a Day in Participants With Type 2 Diabetes and Increased Cardiovascular Risk

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Tirzepatide;   Drug: Insulin Glargine
Sponsor:   Eli Lilly and Company
Active, not recruiting

Effect of Alirocumab on Postprandial Hyperlipemia in Patients With Type 2 Diabetes

Condition:   Type2 Diabetes
Interventions:   Drug: Alirocumab;   Other: Placebo
Sponsors:   Nantes University Hospital;   Regeneron Pharmaceuticals
Recruiting

The Effects of Glycemic Optimization Before Gastric Bypass Surgery

Condition:   Type 2 Diabetes
Intervention:   Biological: gastric bypass
Sponsor:   Imperial College London
Completed

Multi-center, Single Arm, Observational Study to Evaluate the Safety of Dapagliflozin in Type 2 Diabetes Mellitus Patients in China

Condition:   Type 2 Diabetes Mellitus
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Reducing Emergency Department Visits and Improving Glucose Control in Uncontrolled Type 2 Diabetes Using CGM Sensors at Hospital Discharge

Condition:   Type 2 Diabetes Mellitus
Interventions:   Device: Continuous Glucose Monitoring Sensor;   Other: Diabetes Management Instructions
Sponsor:   Albert Einstein Healthcare Network
Recruiting

Effects of Neuromuscular Electrical Stimulation on Glucose Variability in Patients With Type 2 Diabetes

Condition:   Type2 Diabetes Mellitus
Interventions:   Device: NMES;   Device: NMES-placebo
Sponsor:   Hospital de Clinicas de Porto Alegre
Active, not recruiting

Efficacy and Safety of Efpeglenatide Versus Placebo in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin Alone or in Combination With Sulfonylurea

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Efpeglenatide SAR439977;   Drug: Placebo;   Drug: Metformin;   Drug: Sulfonylurea
Sponsor:   Sanofi
Recruiting

Efficacy and Safety of Efpeglenatide Versus Placebo in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Diet and Exercise

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: efpeglenatide (SAR439977);   Drug: placebo
Sponsor:   Sanofi
Active, not recruiting

Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus on Background of Metformin

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: Placebo;   Drug: Metformin
Sponsors:   Lexicon Pharmaceuticals;   Sanofi
Completed

Efficacy and Bone Safety of Sotagliflozin Dose 1 and Dose 2 Versus Placebo in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: Placebo
Sponsors:   Lexicon Pharmaceuticals;   Sanofi
Active, not recruiting

Efficacy and Safety of Sotagliflozin Versus Placebo in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking Insulin Alone or With Other Oral Antidiabetic Agents

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: sotagliflozin (SAR439954);   Drug: insulin glargine (HOE901);   Drug: Placebo
Sponsors:   Lexicon Pharmaceuticals;   Sanofi
Completed

Efficacy and Safety of Sotagliflozin Versus Glimepiride and Placebo in Subjects With Type 2 Diabetes Mellitus That Are Taking Metformin Monotherapy

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: sotagliflozin (SAR439954);   Drug: glimepiride;   Drug: metformin;   Drug: placebo
Sponsors:   Lexicon Pharmaceuticals;   Sanofi
Completed

Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus Not Currently Treated With Antidiabetic Therapy

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: Placebo
Sponsors:   Lexicon Pharmaceuticals;   Sanofi
Completed

Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus on Background of Sulfonylurea Alone or With Metformin

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: placebo;   Drug: Metformin;   Drug: Sulfonylurea
Sponsors:   Lexicon Pharmaceuticals;   Sanofi
Completed

Effect of Sotagliflozin on Cardiovascular Events in Patients With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF Trial)

Condition:   Heart Failure-Type 2 Diabetes Mellitus
Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: Placebo
Sponsors:   Lexicon Pharmaceuticals;   Sanofi
Recruiting

Efficacy and Safety of Sotagliflozin Versus Placebo and Empagliflozin in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking a DPP4 Inhibitor Alone or With Metformin

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: Empagliflozin;   Drug: Placebo
Sponsors:   Lexicon Pharmaceuticals;   Sanofi
Completed

Safety and Tolerability Study of Cotadutide in Japanese Obese Subjects With Type 2 Diabetes Melitus

Condition:   Type 2 Diabetes
Interventions:   Drug: Placebo;   Drug: Cotadutide
Sponsors:   AstraZeneca;   MedImmune LLC
Recruiting

Safety and Efficacy Study of Sotagliflozin on Glucose Control in Patients With Type 2 Diabetes, Moderate Impairment of Kidney Function, and Inadequate Blood Sugar Control

Condition:   Type 2 Diabetes Mellitus-Chronic Kidney Disease Stage 3
Interventions:   Drug: Placebo;   Drug: Sotagliflozin (SAR439954)
Sponsors:   Lexicon Pharmaceuticals;   Sanofi
Completed

A Study to Evaluate Safety and Effects of Sotagliflozin Dose 1 and Dose 2 on Glucose Control in Patients With Type 2 Diabetes, Severe Impairment of Kidney Function and Inadequate Blood Sugar Control

Condition:   Type 2 Diabetes Mellitus-Chronic Kidney Disease Stage 4
Interventions:   Drug: Placebo;   Drug: Sotagliflozin (SAR439954)
Sponsors:   Lexicon Pharmaceuticals;   Sanofi
Completed

Evaluation of Diabetes and WELLbeing Programme

Conditions:   Type 2 Diabetes;   Type 2 Diabetes Treated With Insulin
Intervention:   Behavioral: DWELL (Diabetes and WELLbeing) Programme
Sponsors:   Canterbury Christ Church University;   Interreg 2 Seas Mers Zeeen;   Medway Community Healthcare;   Blackthorn Trust;   Arteveldehogeschool;   Kinetic Analysis;   Centre Hospitalier Douai
Recruiting

Study to Evaluate Safety and Efficacy of Dapagliflozin and Saxagliptin in Patients With Type 2 Diabetes Mellitus Aged 10 to Below 18 Years Old

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Dapagliflozin;   Drug: Saxagliptin;   Drug: Placebo
Sponsor:   AstraZeneca
Recruiting

Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk

Conditions:   Type 2 Diabetes Mellitus;   Chronic Kidney Diseases
Interventions:   Drug: Sotagliflozin (SAR439954);   Drug: Placebo
Sponsors:   Lexicon Pharmaceuticals;   Sanofi
Active, not recruiting

Lanifibranor in Patients With Type 2 Diabetes & Nonalcoholic Fatty Liver Disease

Conditions:   Nonalcoholic Fatty Liver Disease (NAFLD);   Type 2 Diabetes (T2DM)
Interventions:   Drug: Lanifibranor;   Other: Placebo
Sponsors:   University of Florida;   Inventiva Pharma
Recruiting

A Double-blind Study to Assess 2 Doses of an Investigational Product for 16 Weeks in Participants With Non-alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus

Condition:   Non-alcoholic Steatohepatitis
Interventions:   Drug: Placebo;   Drug: PF-06835919
Sponsor:   Pfizer
Recruiting

Closed-loop in Adults With T2D Requiring Dialysis

Conditions:   Type 2 Diabetes;   End Stage Renal Disease
Interventions:   Device: CamAPS HX Closed-loop;   Other: Multiple Daily Insulin Injections (Control)
Sponsors:   University of Cambridge;   University Hospital Inselspital, Berne
Recruiting

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Resilience-Based Diabetes Self-Management Education (RB-DSME) for African Americans

Condition:   Type 2 Diabetes
Interventions:   Behavioral: Resilience-Based Diabetes Self-Management Education;   Behavioral: Standard Diabetes Self-Management Education
Sponsors:   University of Texas at Austin;   University of Colorado, Aurora
Recruiting

Ertugliflozin Type 2 Diabetes Mellitus (T2DM) Pediatric Study (MK-8835/PF-04971729) (MK-8835-059)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Ertugliflozin 5 mg;   Drug: Ertugliflozin 15 mg;   Drug: Placebo;   Biological: Insulin;   Drug: Metformin
Sponsors:   Merck Sharp & Dohme Corp.;   Pfizer
Recruiting

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Condition:   Diabetic Kidney Disease
Interventions:   Drug: Finerenone (BAY94-8862);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting

Managing DIabetes Remission After Combined Therapy in EarLy Stage of DiabetEs

Condition:   Newly Diagnosed Type 2 Diabetes
Interventions:   Drug: Metformin-Sitagliptin-Empaglifozin-Pioglitazone;   Drug: Standard of care
Sponsor:   Azienda Ospedaliero-Universitaria di Parma
Not yet recruiting

A Clinical Study to Assess the Effect of Vildagliptin on Beta Cell Function in Drug Naive Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: vildagliptin;   Drug: placebo
Sponsor:   Novartis Pharmaceuticals
Completed

Genetic and Epigenetic Risk of T2D in the UAE

Conditions:   Diabetes Mellitus, Type 2;   Obesity
Intervention:  
Sponsor:   Imperial College London Diabetes Centre
Recruiting

Clinical Feasibility and Efficacy of Intermittent Use of a Fasting Mimicking Diet in the Treatment of Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Intervention:   Other: Fasting Mimicking diet
Sponsors:   Leiden University Medical Center;   Dutch Diabetes Research Foundation;   Health Holland;   IFOM, The FIRC Institute of Molecular Oncology;   L-Nutra
Recruiting

Benefits of Insulin Supplementation for Correction of Hyperglycemia in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Insulin glargine;   Drug: Insulin aspart;   Drug: Supplemental insulin aspart
Sponsor:   Emory University
Active, not recruiting

Person-Centered, Occupation Based Therapy for Type 2 Diabetes

Conditions:   Diabetes Mellitus, Type 2;   Occupational Therapy
Intervention:   Behavioral: Person centered, occupation based intervention support with problem solving therapy
Sponsors:   Uskudar University;   Hacettepe University
Completed

Effects of Empagliflozin on Cardiac Microvasculature and Insulin Sensitivity in Subjects With Type 2 Diabetes

Conditions:   Type2 Diabetes;   Insulin Sensitivity
Interventions:   Drug: Empagliflozin 25 MG;   Drug: Placebo oral tablet
Sponsors:   University of Virginia;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

The Study Will Evaluate Average 24-hr Sodium Excretion During Dapagliflozin Treatment in Patients With Type 2 Diabetes Mellitus With Preserved or Impaired Renal Function or Non-diabetics With Impaired Renal Function.

Conditions:   Diabetes Mellitus, Type 2;   Kidney Function Tests
Intervention:   Drug: Dapagliflozin
Sponsor:   AstraZeneca
Recruiting

An Alternative Approach to Improve Hyperglycemia Among Type 2 Diabetes Patients

Condition:   Type2 Diabetes
Interventions:   Dietary Supplement: Bitter melon juice (100 ml);   Behavioral: Exercise
Sponsor:   Arizona State University
Completed

Prebiotics and Metformin Improve Gut and Hormones in Type 2 Diabetes in Youth (MIGHTY-fiber)

Condition:   Diabetes
Interventions:   Dietary Supplement: Biomebliss;   Drug: Metformin;   Dietary Supplement: Placebo
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting

Real-world Health Outcomes in Canadian Patients Using Semaglutide

Condition:   Type 2 Diabetes
Intervention:   Drug: Semaglutide
Sponsor:   LMC Diabetes & Endocrinology Ltd.
Completed

Efficacy and Safety of Vildagliptin Compared to Metformin in Elderly Drug Naive Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Vildagliptin 100 mg qd;   Drug: Metformin 1500 mg daily
Sponsor:   Novartis Pharmaceuticals
Completed

Mechanistic Evaluation of Glucose-lowering Strategies in Patients With Heart Failure

Conditions:   Type 2 Diabetes Mellitus;   Heart Failure
Interventions:   Drug: Saxagliptin;   Drug: Sitagliptin;   Drug: Placebo to match saxagliptin;   Drug: Placebo to match sitagliptin
Sponsor:   AstraZeneca
Completed

Effects of Walking and Heating on Vascular Function in Diabetic Patients

Condition:   Type 2 Diabetes Mellitus
Interventions:   Behavioral: Walking;   Behavioral: Lower body heating
Sponsor:   University of Missouri-Columbia
Recruiting

Benefits of Continuous Glucose Monitoring With GEM Lifestyle Modification for Adults With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Behavioral: GEM lifestyle modification & continuous glucose monitoring;   Other: Routine Care
Sponsors:   University of Virginia;   DexCom, Inc.
Active, not recruiting

Corazon de la Familia (Heart of the Family)

Conditions:   Risk Reduction Behavior;   Diabetes Mellitus, Type 2;   Cardiovascular Diseases
Interventions:   Behavioral: Family-focused intervention arm;   Behavioral: Individual-focused intervention arm
Sponsors:   Gia Mudd;   National Institute of Nursing Research (NINR);   National Institutes of Health (NIH)
Recruiting

Personalised Medicine in Pre-diabetes and Early Type 2 Diabetes

Conditions:   Pre Diabetes;   Type 2 Diabetes Mellitus
Interventions:   Drug: Metformin + Healthy diet;   Drug: Metformin + Personalized diet
Sponsors:   Garvan Institute of Medical Research;   Weizmann Institute of Science
Recruiting

Treatment Adherence Intervention in Patients With Type 2 Diabetes and Comorbid Depression

Conditions:   Diabetes Mellitus, Type 2;   Depression
Intervention:   Behavioral: Telephone Intervention Group
Sponsors:   Instituto de Investigación Sanitaria Aragón;   Universidad de Zaragoza
Active, not recruiting

A Clinical Trial of Overweight/Obesity With Type 2 Diabetes

Conditions:   Diabetes Mellitus, Type 2;   Overweight and Obesity
Interventions:   Dietary Supplement: Light-Fat Rice® combined with Active Peptide®+ lifestyle guidance;   Dietary Supplement: A staple food of comparable energy containing a small amount of dietary fiber combined with a comparable energy maltodextrin + lifestyle guidance
Sponsors:   Peking Union Medical College Hospital;   Hebei Dongfangyun Health Management Co.,Ltd
Recruiting

A Research Study of How Semaglutide Works in People With Disease Affecting the Heart and/or Blood Vessels and Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

Reduced Occupational Sitting in Type 2 Diabetes Using mHealth (Mobile Health)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Behavioral: Patient-centered counselling and written material;   Behavioral: mHealth
Sponsors:   Umeå University;   Norrbottens County Council;   Vastra Gotaland Region;   Region Östergötland;   Stockholm County Council, Sweden;   Region Örebro County
Recruiting

The Effect Effect of Empagliflozin on Oxidative Stress in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Empagliflozin;   Drug: Placebo
Sponsors:   Henrik Enghusen Poulsen;   University Hospital, Gentofte, Copenhagen;   University of Copenhagen
Active, not recruiting

A Research Study, Looking at How Tresiba® Works in People With Type 2 Diabetes in Local Clinical Practice in Saudi Arabia

Condition:   Diabetes Mellitus, Type 2
Intervention:   Drug: Insulin degludec
Sponsor:   Novo Nordisk A/S
Enrolling by invitation

Long Term Daily Use of JARDIANCE® Tablets in Japanese Patients With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Intervention:   Drug: Jardiance
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting

Treating Type 2 Diabetes by Reducing Postprandial Glucose Elevations: A Paradigm Shift in Lifestyle Modification

Condition:   Diabetes Mellitus, Type 2
Interventions:   Behavioral: Weight reduction training;   Behavioral: PPG training;   Behavioral: discrete BG feedback;   Behavioral: continuous BG feedback
Sponsors:   University of Virginia;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

JARDIANCE Regulartory Post Marketing Surveillance in Korean Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: JARDIANCE 10mg;   Drug: JARDIANCE 25mg
Sponsor:   Boehringer Ingelheim
Active, not recruiting

A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Recruiting

A Study of Tirzepatide in Chinese Participants With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Tirzepatide;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Not yet recruiting

A Study of LY3209590 in Japanese Participants With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: LY3209590;   Drug: Insulin Degludec
Sponsor:   Eli Lilly and Company
Not yet recruiting

A Study of Tirzepatide in Participants With Type 2 Diabetes Mellitus

Conditions:   Diabetes Mellitus, Type 2;   Hypoglycemia
Interventions:   Drug: Tirzepatide;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Not yet recruiting

Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes and Moderate Renal Impairment

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Completed

Genetics of Type 2 Diabetes in West Africans

Conditions:   Hypertension;   Diabetes
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

A Study to Test Whether Different Doses of BI 456906 Are Effective in Treating Adults With Type 2 Diabetes.

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: BI 456906;   Drug: Placebo;   Drug: Semaglutide
Sponsor:   Boehringer Ingelheim
Not yet recruiting

Diabetes Type 2 in the Eastern Region of Morocco

Conditions:   Quality of Life;   Diabetes Mellitus, Type 2;   Adherence, Medication;   Diet Habit
Intervention:  
Sponsors:   Universiteit Antwerpen;   Artesis Plantijn University College, Antwerp;   Université Mohammed Premier, Oujda;   Vliruos
Recruiting

Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Diet and Exercise Only

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: placebo
Sponsor:   Novo Nordisk A/S
Completed

A Research Study Comparing a New Medicine Oral Semaglutide to Sitagliptin in People With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Oral semaglutide;   Drug: Sitagliptin;   Drug: Placebo (oral semaglutide);   Drug: Placebo (sitagliptin)
Sponsor:   Novo Nordisk A/S
Recruiting

A Research Study Comparing a New Medicine Oral Semaglutide to Placebo in People With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Oral semaglutide;   Drug: Placebo
Sponsor:   Novo Nordisk A/S
Recruiting

Efficacy and Safety of Oral Semaglutide Using a Flexible Dose Adjustment Based on Clinical Evaluation Versus Sitagliptin in Subjects With Type 2 Diabetes Mellitus.

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: semaglutide;   Drug: sitagliptin
Sponsor:   Novo Nordisk A/S
Completed

A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide, Insulin Degludec and Liraglutide in Japanese Subjects With Type 2 Diabetes Mellitus.

Conditions:   Diabetes;   Diabetes Mellitus, Type 2
Interventions:   Drug: insulin degludec/liraglutide;   Drug: insulin degludec;   Drug: liraglutide
Sponsor:   Novo Nordisk A/S
Completed

Nutritional Strategy for Glycemic Control in Patients With Type 2 Diabetes Mellitus (NUGLIC)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Behavioral: Nutritional Strategy;   Behavioral: Dietary Prescription
Sponsor:   Hospital do Coracao
Recruiting

Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity

Conditions:   Obesity;   Overweight
Interventions:   Drug: Semaglutide 1.0 mg;   Drug: Semaglutide 2.4 mg;   Drug: Placebo I (Semaglutide);   Drug: Placebo II (Semaglutide)
Sponsor:   Novo Nordisk A/S
Active, not recruiting

A Research Study in People With Type 2 Diabetes to Compare Two Types of Insulin: Insulin 287 and Insulin Glargine

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Insulin 287;   Drug: Insulin glargine U100
Sponsor:   Novo Nordisk A/S
Completed

DISCOVER Global Registry

Condition:   Type 2 Diabetes
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Stories for Change: Digital Storytelling for Diabetes Self-Management Among Somali Adults

Condition:   Type2 Diabetes
Intervention:   Behavioral: Digital Storytelling Intervention
Sponsor:   Mayo Clinic
Recruiting

Rosuvastatin/Ezetimibe Versus Rosuvastatin in ASCVD Patients With Type 2 DM

Conditions:   Atherosclerotic Cardiovascular Disease;   Type 2 Diabetes Mellitus
Interventions:   Drug: Rosuvamibe;   Drug: Monorova
Sponsor:   Yuhan Corporation
Recruiting

Substitution of Sulfonylureas With New Generation of Hypoglycemic Drugs for the Treatment of Type 2 Diabetes Mellitus

Conditions:   T2DM (Type 2 Diabetes Mellitus);   Diet, Healthy;   Renal Function Disorder;   Albuminuria
Intervention:   Drug: Sulfa-zero: possible benefits of the treatment of new generation hypoglycaemic drugs compared to sulphonylureas
Sponsor:   University of Milan
Recruiting

Bioenergetics and Metabolism in Pediatric Populations

Conditions:   Obesity;   Type 2 Diabetes Mellitus;   Insulin Resistance
Intervention:  
Sponsors:   Arkansas Children's Hospital Research Institute;   National Institutes of Health (NIH);   National Institute of General Medical Sciences (NIGMS);   University of Arkansas
Active, not recruiting

Regulatory Request NIS in Korea

Condition:   Diabetes Mellitus, Type 2
Intervention:   Drug: JARDIANCE DUO®
Sponsor:   Boehringer Ingelheim
Recruiting

Medical Assistant Health Coaching for Diabetes in Diverse Primary Care Settings

Condition:   Type 2 Diabetes Mellitus (T2DM)
Intervention:   Behavioral: Medical Assistant Health Coaching
Sponsors:   Scripps Whittier Diabetes Institute;   San Diego State University
Active, not recruiting

Fatty Acid Radiotracer Comparison Study in Heart Failure Patients

Conditions:   Heart Failure;   Obesity;   Type 2 Diabetes Mellitus;   Health Normal Volunteer Subjects
Intervention:   Drug: [18F]FluorbetaOx
Sponsor:   Washington University School of Medicine
Completed

The Healthy Eating With APP technologY Study

Conditions:   Type 2 Diabetes Mellitus;   Dietary Habits
Intervention:   Behavioral: App-technology for healthy eating habits
Sponsor:   Karolinska Institutet
Recruiting

A Phase IV Study in Drug-Naive Patients With T2DM in China

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Dapagliflozin;   Drug: Acarbose
Sponsor:   AstraZeneca
Terminated

Cryovagotomy Diabetes Trial

Conditions:   Diabete Type 2;   Diabetes Mellitus;   Obesity
Interventions:   Device: Visual-ICE Cryoablation System;   Behavioral: Lifestyle Intervention
Sponsor:   Emory University
Not yet recruiting

Retinal and Cognitive Dysfunction in Type 2 Diabetes

Conditions:   Retinal Function;   Cognitive Dysfunction;   Microperimetry
Intervention:  
Sponsors:   Hospital Universitari Vall d'Hebron Research Institute;   Queen's University, Belfast;   Association for Innovation and Biomedical Research on Light and Image;   UMC Utrecht;   University of Medical Centre Amsterdam;   University of Rome Tor Vergata;   Ospedale San Raffaele;   University of Milan;   University of Southern Denmark;   Azienda Ospedaliero Universitaria Maggiore della Carita;   Hospital Mutua de Terrassa;   Institut Catala de Salut;   Faculty of Medicine, University of Montenegro;   Clinical Center of Montenegro;   University of Cadiz;   European Infrastructure for Translational Research;   Alzheimer Europe;   IDF Europe;   Anaxomics Biotech;   Oxurion;   Genesis Biomed
Not yet recruiting

Imagine to Remember: Improving Medication Adherence in Pre- and Type 2 Diabetes

Condition:   Medication Adherence
Interventions:   Behavioral: Episodic Future Thinking introduced at 6 weeks;   Behavioral: Episodic Future Thinking introduced at 8 weeks;   Behavioral: Episodic Future Thinking introduced at 10 weeks
Sponsor:   State University of New York at Buffalo
Recruiting

Integration of Education Based-Application and "CARE Coaching Model" in Management of Type 2 Diabetes Mellitus Patients Using Insulin

Condition:   Diabetes Mellitus, Type 2
Interventions:   Other: Mobile Application-Based Diabetes Education;   Other: Health Coaching
Sponsor:   Indonesia University
Active, not recruiting

Liraglutide for HIV-associated Neurocognitive Disorder

Conditions:   HIV Infection;   Diabetes Mellitus Type 2;   Obesity;   Overweight;   Metabolic Syndrome
Intervention:   Drug: Liraglutide
Sponsors:   Temple University;   The Comprehensive NeuroAIDS Center (CNAC) at Temple University
Suspended

Efficacy and Safety of GP40081 Сompared to NovoMix® 30 FlexPen® in Type 2 Diabetes Mellitus Patients

Conditions:   Diabetes Mellitus, Type 2;   Diabetes Mellitus
Interventions:   Drug: GP40081;   Drug: NovoMix 30
Sponsor:   Geropharm
Recruiting

A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Italy, as Part of Local Clinical Practice

Condition:   Diabetes Mellitus, Type 2
Intervention:   Drug: Semaglutide
Sponsor:   Novo Nordisk A/S
Enrolling by invitation

Impact of Empaglifozine on Cardiac Ectopic Fat

Condition:   Type 2 Diabetes
Intervention:   Drug: Empagliflozin 10Mg Tab
Sponsor:   Assistance Publique Hopitaux De Marseille
Completed

Korean Observational Study to Evaluate the Efficacy and Safety of Anagliptin Switching From Other DPP4is in type2 DM

Condition:   Type 2 Diabetes Mellitus
Intervention:   Drug: Anagliptin
Sponsor:   JW Pharmaceutical
Recruiting

Text Messaging and Cardiovascular Health in Diabetes Mellitus

Condition:   Type 2 Diabetes Mellitus
Intervention:   Behavioral: Text messaging
Sponsor:   Nanfang Hospital of Southern Medical University
Recruiting

Dynamically Tailored Behavioral Interventions in Diabetes

Condition:   Type 2 Diabetes
Intervention:   Behavioral: T2.coach
Sponsors:   Columbia University;   Clinical Directors Network;   University of Colorado, Denver;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Investigating the Use of Quercetin on Glucose Absorption in Obesity, and Obesity With Type 2 Diabetes

Conditions:   Obesity;   Diabetes
Interventions:   Other: Quercetin;   Other: Placebo
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Liver and Metabolic Effects of Insulin Pump Therapy in Diabetics Type 2 With Non-alcoholic Hepatic Steatosis

Condition:   Type 2 Diabetes (T2D)
Interventions:   Procedure: Insulin pump therapy;   Procedure: Multi-injection treatment ( MDI ).
Sponsors:   Nantes University Hospital;   University Hospital, Angers
Not yet recruiting

Post-authorization Safety Study in Type 2 Diabetic Patients in Saudi Arabia Treated With Empagliflozin to Assess the Incidence of Ketoacidosis, Severe Complications of Urinary Tract Infection, Volume Depletion, and Dehydration

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Empagliflozin;   Drug: Dipeptidyl-peptidase 4 (DPP-4) inhibitors
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Study of Sulphonylurea Synergy With Incretins

Condition:   Type 2 Diabetes Mellitus
Intervention:   Drug: Gliclazide
Sponsors:   University of Dundee;   NHS Tayside
Completed

A Causative Role for Amylin in Diabetic Peripheral Neuropathy

Conditions:   Type2 Diabetes;   Peripheral Neuropathy
Intervention:  
Sponsor:   John Slevin
Recruiting

Forxiga Tablets Specific Clinical Experience Investigation for Long-term Use

Condition:   Type 2 Diabetes Mellitus
Intervention:  
Sponsor:   AstraZeneca
Completed

Corneal Nerves Function and Structure

Condition:   Diabetic Peripheral Neuropathy
Intervention:   Dietary Supplement: Blackmores Omega Daily (4 1g capsules per day)
Sponsors:   VA Office of Research and Development;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting

Diabetes Study of Linagliptin and Empagliflozin in Children and Adolescents (DINAMO)TM

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Linagliptin;   Drug: Empagliflozin;   Drug: Placebo
Sponsor:   Boehringer Ingelheim
Recruiting

A Study to Evaluate the Efficacy and Safety of Dual add-on Therapy With Gemigliptin 50 mg and Dapagliflozin 10 mg Added to Metformin Who Have Inadequate Glycemic Control on Metformin Alone

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Gemigliptin 50mg;   Drug: Dapagliflozin 10mg
Sponsor:   LG Chem
Not yet recruiting

Urinary Vitamin C Loss in Diabetic Subjects

Conditions:   Diabetes Type 1;   Diabetes Type 2;   Healthy Volunteers
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Effect of Resistance Training Associated With Whole-Body Vibration in Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Other: Resistance training associated with vibration;   Other: Resistance training associated with vibration sham
Sponsor:   Universidade Federal de Pernambuco
Recruiting

New Patient Support Program in Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Intervention:   Other: Follow up
Sponsors:   Farmacia La Regina dott. Rocco Vito;   Federfarma Campania;   Federfarma Salerno;   HTN - Health Telematic Network srl;   BSI - Biochemical Systems International spa;   Next Sight srl
Completed

GA 6: The Blood Glucose-lowering Effect of Glucose-dependent Insulinotropic Polypeptide

Condition:   Type2 Diabetes
Interventions:   Other: Placebo;   Other: GIP receptor antagonist;   Drug: DPP-4 inhibitor;   Other: Placebo tablet
Sponsor:   University Hospital, Gentofte, Copenhagen
Recruiting

Safety and Efficacy of Herbal Tea in Type 2 Diabetics

Conditions:   Type 2 Diabetes;   Herbal Medicine Adverse Reaction
Interventions:   Dietary Supplement: Antidiabetic Herbal Tea;   Dietary Supplement: Herbal Tea
Sponsors:   Josip Juraj Strossmayer University of Osijek;   Dom zdravlja Osijek (Health Centre Osijek);   Osijek University Hospital
Completed

Effect of Intermittent Calorie Restriction on NAFLD Patients With Disorders of Glucose Metabolism

Conditions:   Non-Alcoholic Fatty Liver Disease (NAFLD);   Disorders of Glucose Metabolism;   Type 2 Diabetes;   Impaired Glucose Regulation
Interventions:   Behavioral: Intermittent caloric restriction;   Behavioral: 25kcal/kg/d diet
Sponsor:   Shanghai Zhongshan Hospital
Not yet recruiting

Empaglifozin in Early Diabetic Kidney Disease

Conditions:   Diabetic Kidney Disease;   Diabetes Mellitus Type 2
Interventions:   Drug: Empagliflozin;   Other: Placebo
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Withdrawn

Qatar Diabetes Mobile Application Trial

Condition:   Type2 Diabetes Mellitus
Interventions:   Device: Droobi;   Other: Standard of care
Sponsors:   Hamad Medical Corporation;   Qatar Computing Research Institute (QCRI);   Droobi Health
Recruiting

A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight

Conditions:   Overweight;   Obesity
Interventions:   Drug: Tirzepatide;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Recruiting

Genetics of Obesity, Diabetes, and Heart Disease in African Diaspora Populations

Conditions:   Diabetes;   Cardiovascular Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Enrolling by invitation

Meta-analysis of Low-calorie Sweetened Beverages and Cardiometabolic Outcomes

Conditions:   Adiposity;   Metabolic Syndrome;   Type 2 Diabetes;   Cardiovascular Diseases;   Mortality
Interventions:   Other: Change in LCSBs Intake;   Other: Substitute LCSBs for SSBs or Water
Sponsor:   University of Toronto
Active, not recruiting

A Study of HTD1801 in Adults With Nonalcoholic Steatohepatitis (NASH) and Type 2 Diabetes Mellitus (T2DM)

Conditions:   Fatty Liver, Nonalcoholic;   NAFLD;   Nonalcoholic Fatty Liver Disease;   Nonalcoholic Steatohepatitis;   Digestive System Diseases
Interventions:   Drug: HTD1801;   Drug: Placebo
Sponsor:   HighTide Biopharma Pty Ltd
Active, not recruiting

Toronto Gestational Glucose Tolerance Cohort

Condition:   Type 2 Diabetes, Gestational Diabetes, Pre-diabetes
Intervention:   Other: There is no intervention. An exposure of interest is glucose tolerance status in pregnancy
Sponsors:   Mount Sinai Hospital, Canada;   Canadian Institutes of Health Research (CIHR)
Recruiting

A Study Comparing the Injection Site Pain Experience After the Injection of Semaglutide B and Semaglutide D With 2 Different Injection Pens, a Compound for the Treatment of Type 2 Diabetes and Obesity

Conditions:   Healthy Volunteers Diabetes Mellitus, Type 2;   Healthy Volunteers Overweight;   Healthy Volunteers Obesity
Interventions:   Drug: Semaglutide (administered by DV3396 pen);   Drug: Semaglutide (administered by PDS290 pen)
Sponsor:   Novo Nordisk A/S
Completed

Effectiveness and Implementation of the Assessment of Burden of Chronic Conditions (ABCC)-Tool

Conditions:   Chronic Obstructive Pulmonary Disease;   Asthma;   Diabetes Mellitus, Type 2;   Heart Failure
Intervention:   Device: Assessment of Burden of Chronic Conditions (ABCC)-tool
Sponsors:   Maastricht University;   Netherlands Instititute for Health Services Research;   TNO;   University of Twente
Recruiting

The WISE (Weightloss Intervention Surgical Effects) Brain Study

Conditions:   Diabetes;   Weightloss
Interventions:   Procedure: Bariatric Surgery Candidates;   Other: Non surgical/Community volunteers
Sponsors:   University of Florida;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Starter Kit Study in Insulin naïve Patients

Condition:   Diabetes Mellitus, Type 2
Intervention:   Device: Starter Kit Algorithm
Sponsors:   Signe Schmidt;   Technical University of Denmark;   Novo Nordisk A/S
Completed

DPP-4 Inhibitors and Acute Myocardial Infarction:Effects on Platelet Function

Condition:   Platelet Aggregation During Acute Myocardial Infarction
Interventions:   Drug: sitagliptin OR saxagliptin;   Drug: placebo
Sponsors:   University of Sao Paulo General Hospital;   InCor Heart Institute
Recruiting

Peanuts and Glycemic Control

Conditions:   Type2 Diabetes;   Cardiovascular Diseases
Interventions:   Drug: Peanut;   Drug: High carbohydrate snack
Sponsors:   Penn State University;   The Peanut Institute
Completed

Testosterone Therapy and Bone Quality in Men With Diabetes and Hypogonadism

Conditions:   Type 2 Diabetes Mellitus;   Hypogonadism
Interventions:   Drug: Testosterone gel 1.62%;   Drug: Placebo
Sponsor:   VA Office of Research and Development
Recruiting

Reversibility of Brain Glucose Transport and Metabolism in T2DM: an Intervention Study

Condition:   Diabete Type 2
Intervention:   Behavioral: Intensification of insulin regimen/Nutrition
Sponsor:   Yale University
Not yet recruiting

Natural History of Autoimmune Diabetes and Its Complications

Conditions:   Diabetes Mellitus Type 1;   Diabetes Mellitus Type 2
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Quantitative Assessment of Painful Diabetic Peripheral Neuropathy After High Frequency Spinal Cord Stimulation

Condition:   Painful Diabetic Neuropathy
Intervention:   Device: High Frequency Spinal Cord Stimulator
Sponsor:   Mayo Clinic
Recruiting

DANHEART (H-HeFT and Met-HeFT)

Conditions:   Heart Failure;   Diabetes
Interventions:   Drug: Hydralazine Isosorbide Dinitrate;   Drug: Placebo Oral Tablet;   Drug: Metformin Hydrochloride
Sponsors:   Henrik Wiggers;   Danish Heart Foundation;   Danish Council for Independent Research;   The Danish Regions: Foundation for Medical Research;   The Novo Nordisk Foundation;   The Aase og Ejnar Danielsen Foundation
Recruiting

Fat Cell Size in Insulin Resistance

Condition:   Obesity
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Bariatric Surgeries and Glucose Homeostasis During a Mixed Meal Test

Condition:   Obesity
Interventions:   Procedure: Roux-en-Y-gastric bypass;   Procedure: laparoscopic adjustable gastric banding;   Procedure: laparoscopic sleeve gastrectomy;   Other: diet treatment
Sponsors:   Azienda Ospedaliera Universitaria Integrata Verona;   Universita di Verona
Completed

Cooking for Health

Condition:   Diabetes Mellitus, Type 2
Intervention:   Behavioral: Budgeting, purchasing and cooking educational intervention
Sponsors:   University of Washington;   Medstar Health Research Institute;   Missouri Breaks Industries Research, Inc.;   National Institute on Minority Health and Health Disparities (NIMHD)
Not yet recruiting

Acute Effects of an Oral Fat Load on Skeletal Muscle and Hepatic Insulin Sensitivity

Condition:   Insulin Sensitivity
Intervention:   Biological: fat orally
Sponsors:   German Diabetes Center;   German Center for Diabetes Research
Recruiting

Community Based DPP Program for Hispanic/Latino Females

Conditions:   Pre Diabetes;   Obesity
Intervention:   Behavioral: Diabetes prevention program culturally tailored
Sponsor:   Loyola University
Recruiting

Gene-by-Stress Interactions in Intervention Studies Significance

Condition:   Cardiovascular Diseases
Interventions:   Drug: Ziprasidone;   Drug: Lorcaserin;   Drug: Placebo Oral Tablet
Sponsors:   Duke University;   National Heart, Lung, and Blood Institute (NHLBI)
Terminated

Citrulline Efficacy to Improve Carbohydrate Metabolism Abnormalities in the Patient Treated With High Doses of Statin

Condition:   Atorvastatin
Interventions:   Dietary Supplement: citrulline supplementation;   Dietary Supplement: placebo supplementation;   Procedure: glucose tolerance test
Sponsor:   Hospices Civils de Lyon
Not yet recruiting

Gestational Diabetes

Condition:   Gestational Diabetes
Intervention:  
Sponsors:   University Hospital Tuebingen;   Deutsches Diabeteszentrum (DDZ), Leibniz-Institut Düsseldorf;   Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus, TU Dresden;   Klinik für Diabetologie an der Medizinischen Klinik - Innenstadt, LMU München;   Universitätsklinik Heidelberg, Abteilung Innere Medizin I, Schwerpunkt Endokrinologie und Stoffwechsel;   Universitätsklinikum Leipzig, IFB Adipositas Erkrankungen
Recruiting

Technology Delivered Diabetes-Modified Behavioral Activation Treatment

Condition:   Diabetes Mellitus, Type 2
Interventions:   Behavioral: TECH DM-BAT;   Behavioral: TECH DMBAT Active Comparator;   Behavioral: TECH DMBAT Other
Sponsor:   Medical College of Wisconsin
Terminated

Effect of Exercise on Genes That Control Muscle Function

Condition:   Healthy
Intervention:   Other: Exercise
Sponsors:   Baylor College of Medicine;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   US Department of Veterans Affairs
Recruiting

Low-Carbohydrate Dietary Pattern on Glycemic Outcomes Trial

Conditions:   Diabetes;   PreDiabetes;   Metabolic Disease;   Hyperglycemia;   Diet Modification;   Glucose Intolerance;   Glucose Metabolism Disorders (Including Diabetes Mellitus);   Endocrine System Diseases
Intervention:   Behavioral: Low-Carbohydrate Diet
Sponsors:   Tulane University School of Public Health and Tropical Medicine;   National Institute of General Medical Sciences (NIGMS)
Recruiting

Shared Decision Making in Diabetes Prevention for Women With a History of GDM

Condition:   Gestational Diabetes
Intervention:   Behavioral: Shared decision-making with pharmacists
Sponsor:   University of California, Los Angeles
Completed

Using a Transcutaneous Electrical Auricular Stimulator to Harness the Cholinergic Anti-Inflammatory Pathway

Condition:   Healthy Volunteers
Interventions:   Device: Vagus Nerve Stimulation;   Device: Sham Vagus Nerve Stimulation
Sponsor:   Northwell Health
Recruiting

A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome

Condition:   Li-Fraumeni Syndrome
Intervention:   Drug: Metformin
Sponsor:   National Cancer Institute (NCI)
Completed

A Study of LY900020 in Healthy Chinese Participants

Condition:   Healthy
Interventions:   Drug: LY900020;   Drug: Metformin XR;   Drug: Atorvastatin;   Drug: Valsartan
Sponsor:   Eli Lilly and Company
Active, not recruiting

Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese Women

Conditions:   Diabetes;   Fatty Liver;   Obesity;   Healthy Volunteers
Interventions:   Drug: Alpha Tocopherol Vitamin E;   Other: Vitamin C
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting

Effects of Oral Fruit Concentrate Supplementation on Cardiometabolic Parameters.

Condition:   Metabolic Syndrome
Intervention:   Dietary Supplement: Fruit concentrate - either cherry or blueberry
Sponsor:   University of Central Lancashire
Recruiting

Nutritional Supplementation and Insulin Sensitivity

Conditions:   Nitric Oxide;   Insulin Sensitivity;   Vascular Function;   L-arginine;   Nitrate / Nitrite
Interventions:   Dietary Supplement: L-arginine + Nitrate / Nitrite;   Dietary Supplement: Placebo
Sponsors:   Maastricht University Medical Center;   Nutricia Research
Not yet recruiting

Tolerability and Risk of Adverse Events With a Probiotic Supplement

Condition:   Healthy Individuals
Interventions:   Dietary Supplement: Placebo;   Dietary Supplement: High dose F. prausnitzii and D. piger;   Dietary Supplement: Low dose F. prausnitzii and D. piger
Sponsors:   Sahlgrenska University Hospital, Sweden;   Metabogen AB
Completed

Insulin-sensitive Obesity: Lessons From Longitudinal Data

Conditions:   Insulin Sensitivity/Resistance;   Obesity
Intervention:  
Sponsors:   Garvan Institute of Medical Research;   The University of Hong Kong;   Diabetes Australia;   The University of New South Wales;   University of Sydney;   St Vincent's Hospital, Sydney
Completed

Theophylline Treatment for Pseudohypoparathyroidism

Conditions:   Pseudohypoparathyroidism;   Albright Hereditary Osteodystrophy
Interventions:   Drug: Theophylline;   Drug: Placebos
Sponsors:   Vanderbilt University Medical Center;   Harvard University
Recruiting

Testosterone in Bariatric Patients

Conditions:   Bariatric Surgery Candidate;   Male Hypogonadism;   Muscle Loss
Intervention:   Drug: Testosterone Undecanoate
Sponsor:   Hospital of South West Denmark
Not yet recruiting

The Postprandial Effects of Chick-Pea Consumption on Glucose, Insulin, and Gut Hormone Responses (PEA-POD).

Condition:   Postprandial Period
Intervention:   Dietary Supplement: Chickpea powder
Sponsors:   King's College London;   Quadram Institute Bioscience;   New-Food Innovation;   Biotechnology and Biological Sciences Research Council
Enrolling by invitation

Relationship of Central Blood Pressure and Pulse Wave Velocity With Target Organ Damage

Conditions:   Diabetes;   Cardiovascular Disease
Intervention:  
Sponsor:   Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Completed

Hormonal Mechanisms of Sleep Restriction

Condition:   Insulin Resistance
Interventions:   Drug: Ketoconazole;   Drug: Hydrocortisone;   Drug: Testosterone;   Drug: Placebo for ketoconazole;   Drug: Placebo for hydrocortisone;   Drug: Placebo for testosterone
Sponsor:   Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Active, not recruiting

Altered Tumor Oxygenation by Metformin, a Potential Step in Overcoming Radiotherapy Resistance in LACC

Condition:   Cervical Cancer
Interventions:   Drug: Metformin;   Drug: Cisplatin
Sponsor:   Oslo University Hospital
Not yet recruiting

Metabolic Surgery for Steato-Hepatitis

Conditions:   Non-alcoholic Fatty Liver Disease (NAFLD);   Non-Alcoholic Steato-Hepatitis (NASH)
Interventions:   Procedure: Metabolic/Bariatric surgery;   Other: Lifestyle and Diet
Sponsor:   King's College London
Not yet recruiting

Metabolic Defects in Prediabetic Kuwaiti Arabs and Indians

Conditions:   Pathophysiology;   Metabolic Glucose Disorders
Intervention:  
Sponsor:   Dasman Diabetes Institute
Not yet recruiting

Impacts of Lentils on Metabolism and Inflammation

Conditions:   Hypertriglyceridemia;   Inflammation;   Waist, Hypertriglyceridemic
Interventions:   Behavioral: Dietary Lentil;   Behavioral: Control
Sponsor:   Montana State University
Not yet recruiting

First Research Study to Look at How Two Medicines, NNC0480-0389 and Semaglutide, Work Together in Healthy People, in People With High Body Weight and in People With Diabetes

Conditions:   Healthy Volunteers;   Overweight;   Obesity;   Diabetes Mellitus, Type 2
Interventions:   Drug: NNC0480-0389;   Drug: Semaglutide;   Drug: Placebo (NNC0480-0389);   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S
Not yet recruiting

Effects of Empagliflozin on Clinical Outcomes in Patients With Acute Decompensated Heart Failure

Conditions:   Heart Failure Acute;   Heart Failure,Congestive;   Heart Failure; With Decompensation
Interventions:   Drug: Empagliflozin 10 MG;   Drug: Placebo Oral Tablet
Sponsor:   University Medical Center Groningen
Completed

Effectiveness of Dietitian-led Dietary Approach to Management of Diabetes (DIAM-D)

Condition:   Diabetes
Intervention:   Behavioral: Dietitian-led dietary approach to management of diabetes
Sponsor:   Purbanchal University
Not yet recruiting

Hypoxic Exercise and Glucose Metabolism

Conditions:   Obesity;   Insulin Resistance;   Impaired Glucose Tolerance in Obese
Intervention:   Other: Moderate intensity exercise under mild normobaric hypoxia and normoxia
Sponsor:   Maastricht University Medical Center
Recruiting

Does Insulin Sensitivity Impact the Potential of Metformin to Slow Aging

Conditions:   Aging;   Insulin Sensitivity;   Chronic Disease;   Mitochondria;   Insulin Resistance
Interventions:   Drug: Metformin;   Drug: Placebo oral tablet
Sponsors:   Oklahoma Medical Research Foundation;   National Institute on Aging (NIA);   University of Illinois at Urbana-Champaign;   University of Oklahoma
Recruiting

Financial Incentives and Text Messaging to Improve African American Womens' Glycemic Control

Condition:   Diabetes Mellitus
Intervention:   Behavioral: IM/SMS + Incentive Condition
Sponsor:   University of California, Los Angeles
Recruiting

Scripps Digital Diabetes: Cloud-Based Continuous Glucose Monitoring (CB CGM)

Condition:   Diabetes Mellitus, Type 2
Intervention:   Device: Cloud-Based Continuous Glucose Monitoring
Sponsors:   Scripps Whittier Diabetes Institute;   DexCom, Inc.
Not yet recruiting

Safety Evaluation and Effect of Food Supplement Containing Dietary Fiber From Cassava on the Alterations of Physiological Parameters in Overweight Female Volunteers

Condition:   Overweight
Intervention:   Dietary Supplement: Cassava dietary fiber capsule
Sponsor:   Khon Kaen University
Completed

Online Obesity Treatment in Primary Care (Rhode Island, USA)

Condition:   Overweight and Obesity
Interventions:   Behavioral: Training to Identify Eligible Patients and Direct them to Online Obesity Treatment Program;   Behavioral: Training to Motivate and Support Patients' Weight Loss;   Behavioral: Online Behavioral Weight Loss Intervention;   Behavioral: Control Intervention for Weight Loss Maintenance and Weight Gain Prevention;   Behavioral: Monthly Lessons and Feedback Intervention for Weight Loss Maintenance and Weight Gain Prevention;   Behavioral: Refresher Courses for Weight Loss Maintenance and Weight Gain Prevention
Sponsors:   The Miriam Hospital;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Enrolling by invitation

Hepatic Mitochondrial Function in Youth

Conditions:   Hepatic Steatosis;   Bariatric Surgery Candidate;   Adolescent Obesity;   Obesity
Intervention:  
Sponsor:   University of Colorado, Denver
Recruiting

Blood Pressure and Subclinical Organ Damage

Condition:   Diabetes Mellitus
Intervention:  
Sponsors:   Fundacion para la Investigacion y Formacion en Ciencias de la Salud;   Castilla-León Health Service;   Carlos III Health Institute
Completed

Metabolic and Bone Changes After Adjuvant Cancer Treatments in Early Non-metastatic Breast Cancer

Conditions:   Bone Fracture;   Glucose, High Blood;   Insulin Resistance;   Blood Pressure, High;   Cholesterolemia
Intervention:  
Sponsor:   Rigshospitalet, Denmark
Recruiting

Cost-utility Analysis, Cost-effectiveness Analysis, Budget Impact Analysis

Condition:   Peripheral Arterial Disease
Interventions:   Other: Systematic screening of AOMI by BPI measurement.;   Other: Management of CVRF by a motivationnal interviewing.
Sponsors:   University Hospital, Tours;   Collèges Régionaux de Médecine Générale- CRMG - 42270 ST PRIEST EN JAREZ;   Collèges Régionaux de Médecine Générale- CRMG - 26330 Châteauneuf-de-Galaure;   Collèges Régionaux de Médecine Générale- CRMG - 29238 BREST;   Collèges Régionaux de Médecine Générale- CRMG - 37400 Amboise;   Collèges Régionaux de Médecine Générale- CRMG - 59110 LA MADELEINE;   Collèges Régionaux de Médecine Générale- CRMG - 63 001 CLERMONT FERRAND;   Collèges Régionaux de Médecine Générale- CRMG - 18600 SANCOINS;   Collèges Régionaux de Médecine Générale- CRMG - 35000 Rennes
Not yet recruiting

Effects of Curcumin Supplementation on Gut Barrier Function in Patients With Metabolic Syndrome

Conditions:   Obesity;   High Blood Pressure;   High Cholesterol;   Type2 Diabetes;   Heart Diseases
Intervention:   Dietary Supplement: Curcumin
Sponsor:   Virginia Commonwealth University
Active, not recruiting

Gene Expression Variation and Implant Wound Healing Among Smokers and Diabetics

Conditions:   Smoking;   Diabetes
Intervention:   Procedure: Dental implant surgery
Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Dental and Craniofacial Research (NIDCR);   National Center for Research Resources (NCRR)
Completed

Effect of LIK066 on Reduction of Fatty Content in Livers of Obese Patients

Condition:   Obese Patients With Non-alcoholic Steatohepatitis (NASH)
Interventions:   Drug: LIK066;   Drug: Placebo
Sponsor:   Novartis Pharmaceuticals
Completed

The Effect of Lactation on Insulin Sensitivity and Lipolysis in Women

Conditions:   GDM;   Lactation
Intervention:   Diagnostic Test: Hyperinsulinemic-euglycemic clamp
Sponsors:   Yale University;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Family Investigation of Nephropathy and Diabetes (F.I.N.D.)

Conditions:   Diabetic Nephropathy;   Diabetes Mellitus;   Diabetic Kidney Disease;   Albuminuria
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Suspended

A 5-year Longitudinal Observational Study of Patients With Nonalcoholic Fatty Liver (NAFL) or Nonalcoholic Steatohepatitis (NASH)

Conditions:   Nonalcoholic Fatty Liver;   Nonalcoholic Steatohepatitis
Intervention:  
Sponsor:   Target PharmaSolutions, Inc.
Recruiting

Effects of Whole Food, Plant-Based Nutrition on Chronic Kidney Disease With Proteinuria

Conditions:   Chronic Kidney Disease Stage 3B;   Chronic Kidney Disease, Stage 4;   Proteinuria
Intervention:   Other: whole food, plant-based diet
Sponsor:   University of Rochester
Recruiting

Biological Age Applied at Ubberup

Conditions:   Healthy Aging;   Lifestyle Risk Reduction
Intervention:   Behavioral: Lifestyle intervention
Sponsors:   University of Copenhagen;   Technical University of Denmark
Not yet recruiting

Diet Interventions in Psoriatic Arthritis

Condition:   Psoriatic Arthritis
Interventions:   Other: Diet M;   Other: Diet L
Sponsors:   University of Pennsylvania;   Women's College Hospital;   NYU Langone Health
Not yet recruiting

The Effect of a Perinatal Health Promotion Program on the Different Levels of Gestational Hyperglycemic Women

Condition:   Gestational Diabetes
Intervention:   Behavioral: Perinatal health promotion program and regular prenatal care
Sponsor:   Kaohsiung Medical University Chung-Ho Memorial Hospital
Recruiting

Vestibular Stimulation to Trigger Adipose Loss (VeSTAL) Clinical Trial

Condition:   Obesity
Intervention:   Device: VeSTAL
Sponsors:   Neurovalens Ltd.;   University of California, San Diego;   University of Ulster;   Exploristics;   Compliance Solutions
Recruiting