Coronary Artery Disease

Clinical Trial Finder

Many patients with coronary artery disease are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

cPSTA System CADLAD Study

Condition:   Coronary Artery Disease
Intervention:   Device: Phase Signal Recorder
Sponsor:   Analytics For Life
Completed

Functional Assessment of Myocardial Ischemia by Intracoronary Electrocardiogram

Conditions:   Coronary Artery Disease;   Stable Angina;   Coronary Artery Stenosis;   Ischemia
Intervention:   Diagnostic Test: Functional Assessment of Myocardial Ischemia by icECG
Sponsor:   University Hospital Inselspital, Berne
Recruiting

Assessment of Patients With suspeCted Coronary Artery Disease by Coronary calciUm fiRst strATegy vErsus Usual Care Approach.

Condition:   Coronary Artery Disease
Interventions:   Diagnostic Test: PET Stress Test;   Other: Non-PET Medical Management
Sponsor:   Intermountain Health Care, Inc.
Not yet recruiting

Assessing the Efficacy of CARDIOgoniometry (CGM) to Determine Physiologically Significant Stenosis in Patients With Stable Coronary Artery Disease in Comparison to Fractional FLOW Reserve - CARDIOFLOW

Condition:   Coronary Artery Disease
Interventions:   Device: Cardiogoniometry (CGM);   Device: Fractional Flow Reserve (FFR)
Sponsor:   Hull and East Yorkshire Hospitals NHS Trust
Completed

AZD5718 Phase IIa Study to Evaluate Efficacy, Safety and Tolerability of Oral AZD5718 in Patients With Coronary Artery Disease (CAD).

Condition:   Coronary Artery Disease
Interventions:   Drug: AZD5718;   Drug: Placebo
Sponsor:   AstraZeneca
Recruiting

Comparison One vs Six Months of Dual Antiplatelet Therapy After Implanted Firehawk TM Stent in High Bleeding Risk Patients With Coronary Artery Disease

Conditions:   Coronary Disease;   Drug Eluting Stent;   Percutaneous Coronary Intervention;   Dual Antiplatelet Therapy
Interventions:   Drug: 1 month DAPT;   Drug: 6 months DAPT
Sponsor:   Shanghai MicroPort Medical (Group) Co., Ltd.
Recruiting

PRISM-GENOMICS-Smoking Cessation for Patients With Coronary Artery Disease Undergoing Cardiac Catheterization or Having a Heart Attack at Barnes Hospital in St. Louis Mo

Conditions:   Coronary Artery Disease;   Smoking Cessation
Interventions:   Other: genotype-guided therapy;   Drug: Nicotine patch;   Behavioral: Smoking cessation counseling
Sponsor:   Washington University School of Medicine
Recruiting

Quantitative Flow Ratio Guided Revascularization Strategy for Patients Undergoing Primary Valve Surgery With Comorbid Coronary Artery Disease

Conditions:   Primary Valvular Heart Disease With Comorbid Coronary Artery Disease;   Planned to Undergo Elective On-pump Valve Surgery Due to Primary Mitral and/or Aortic Valvular Heart Disease
Interventions:   Device: QFR-guided strategy;   Other: CAG-guided strategy
Sponsors:   Ruijin Hospital;   Med-X Research Institute, Shanghai Jiao Tong University
Not yet recruiting

Supporting Patients Undergoing HIgh-Risk PCI Using a High-Flow PErcutaneous Left Ventricular Support Device (SHIELD II)

Condition:   Coronary Artery Disease
Interventions:   Device: HeartMate PHP;   Device: Any Abiomed Impella® device approved for use in high-risk PCI
Sponsor:   Abbott Medical Devices
Recruiting

How Does Antiretroviral Therapy Affect Coronary Atherosclerosis: A Serial CT Study

Conditions:   Coronary Artery Disease;   Hiv
Intervention:   Drug: Biktarvy
Sponsor:   Professor Saye Khoo MD, FRCP
Not yet recruiting

Edoxaban Versus Edoxaban With antiPlatelet Agent In Patients With Atrial Fibrillation and Chronic Stable Coronary Artery Disease

Conditions:   Atrial Fibrillation;   Coronary Artery Disease;   Stable Angina;   Stable Chronic Angina
Interventions:   Drug: Edoxaban;   Drug: Single Antiplatelet Agents
Sponsors:   Gi-Byoung Nam;   CardioVascular Research Foundation, Korea
Recruiting

Prospective International Study of Coronary Subtraction Using 320 Detector Row CT (CorSub)

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Side Branch FFR After Provisional Stenting

Condition:   Coronary Artery Disease
Interventions:   Device: Rotational atherectomy;   Device: Cutting Balloon Angioplasty
Sponsor:   Icahn School of Medicine at Mount Sinai
Completed

Compare Ticagrelor vs Clopidogrel on the Reduction of Arterial Stiffness and Wave Reflectionsin Patients With CAD.

Condition:   Coronary Artery Disease
Intervention:   Drug: Ticagrelor
Sponsors:   Hellenic Cardiovascular Research Society;   AstraZeneca
Completed

Telerehabilitation in Coronary Heart Disease

Conditions:   Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD));   Myocardial Infarction;   Percutaneous Transluminal Cutting Balloon Angioplasty of Popliteal Vein Using Fluoroscopic Guidance
Interventions:   Behavioral: Center-based cardiac rehabilitation;   Behavioral: Home-based training with telemonitoring guidance
Sponsors:   KU Leuven;   Jessa Hospital;   Hasselt University
Completed

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

Condition:   Coronary Artery Disease
Interventions:   Other: Nitrous Oxide;   Other: No Nitrous Oxide
Sponsors:   Bayside Health;   National Health and Medical Research Council, Australia
Completed

Myocardial Perfusion, Coronary Flow Reserve and Kinetic Analysis During Dobutamine Stress Echocardiography

Condition:   Coronary Disease
Intervention:   Diagnostic Test: Stress echocardiography
Sponsor:   Groupe Hospitalier Paris Saint Joseph
Recruiting

Efficacy and Safety Study of Ezetimibe (SCH 58235, MK-0653) in Addition to Atorvastatin in Participants With Coronary Heart Disease or Multiple Cardiovascular Risk Factors (P00693/MK-0653-030)

Condition:   Hypercholesterolemia
Interventions:   Drug: Atorvastatin;   Drug: Ezetimibe;   Drug: Placebo for Ezetimibe;   Drug: Placebo for Atorvastatin
Sponsor:   Merck Sharp & Dohme Corp.
Completed

A Study of SCH 58235 (Ezetimibe) When Added to Ongoing Therapy With a Statin in Participants With Primary Hypercholesterolemia, Known Coronary Heart Disease, or Multiple Cardiovascular Risk Factors (P02173)

Condition:   Primary Hypercholesterolemia
Interventions:   Drug: Ezetimibe;   Drug: Placebo;   Drug: Simivastatin;   Drug: Statin
Sponsor:   Merck Sharp & Dohme Corp.
Completed

The Wire-free Invasive Functional Imaging (WIFI) Study

Condition:   Coronary Artery Disease
Intervention:   Other: QFR (observational)
Sponsor:   Niels Ramsing Holm
Completed

Comparison of CT Angiography With Conventional Angiography and Intravascular Ultrasound in Heart Transplant Patients

Conditions:   Heart Transplantation;   Coronary Artery Disease
Intervention:  
Sponsors:   University of California, San Francisco;   American Roentgen Ray Society
Completed

Semaglutide Treatment On Coronary Progression

Conditions:   Type 2 Diabetes;   Coronary Artery Disease
Interventions:   Drug: Semaglutide 2 MG/1.5 ML Subcutaneous Solution;   Drug: Placebo
Sponsor:   Los Angeles Biomedical Research Institute
Recruiting

Anti-inflammatory Effects of Colchicine in PCI

Condition:   Coronary Artery Disease
Interventions:   Drug: Colchicine;   Drug: Placebo
Sponsors:   NYU Langone Health;   Takeda
Active, not recruiting

PRESSUREwire Study

Conditions:   Coronary Artery Disease;   Acute Coronary Syndrome
Intervention:   Device: Fractional Flow Reserve
Sponsor:   Abbott Medical Devices
Completed

Effect of Mental Stress on Myocardial Perfusion in Women

Condition:   Non-Obstructive Coronary Atherosclerosis
Intervention:   Diagnostic Test: Mental Stress Test
Sponsor:   Guangdong General Hospital
Not yet recruiting

Computed Tomography Coronary Angiography for the Prevention of Myocardial Infarction (The SCOT-HEART 2 Trial)

Condition:   Cardiovascular Diseases
Interventions:   Diagnostic Test: Computed tomography coronary angiography;   Other: ASSIGN Score
Sponsors:   University of Edinburgh;   British Heart Foundation;   NHS Lothian
Not yet recruiting

Virtual 360°-Tour in Coronary Computed Tomography

Conditions:   Coronary Artery Disease;   Anxiety;   Fear
Interventions:   Other: Virtual tour in coronary computed tomography - 360° counselling environment;   Other: Current practice
Sponsors:   University of Oulu;   Oulu University Hospital
Not yet recruiting

Mono- Versus Dual antiPlatelet Therapy During 6-12 Months After New Generation Drug Eluting Stent Implantation

Conditions:   Gastrointestinal Injury;   Ischemic Heart Disease
Interventions:   Drug: Aspirin + clopidogrel;   Drug: Clopidogrel monotherapy;   Drug: Aspirin monotherapy
Sponsors:   Shenyang Northern Hospital;   Changhai Hospital;   ANKON medical technologies (Shanghai)Co.,LTD
Recruiting

Palmar Arch Insufficiency as a Risk Factor for Radial Artery Occlusion After Transradial Catheterization

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   University Hospital Inselspital, Berne
Recruiting

Shockwave Coronary Lithoplasty® Study (Disrupt CAD II)

Condition:   Coronary Artery Disease
Intervention:   Device: IVL Coronary Lithotripsy System
Sponsor:   Shockwave Medical, Inc.
Completed

The First-In-Man Pilot Study of Firehawk

Condition:   Coronary Heart Disease
Intervention:   Device: Rapamycin target-eluting Coronary Stent System
Sponsor:   Shanghai MicroPort Medical (Group) Co., Ltd.
Completed

EVOLVE Short DAPT Study

Condition:   Coronary Artery Disease
Interventions:   Drug: 3 months of dual antiplatelet therapy (DAPT);   Device: SYNERGY Stent System
Sponsor:   Boston Scientific Corporation
Active, not recruiting

Non-inferiority Study Comparing Firehawk Stent With Abbott Xience Family Stent (TARGET-AC)

Condition:   Coronary Artery Disease
Interventions:   Device: Firehawk™ stent system;   Device: Abbott Xience family Everolimus-Eluting Stent
Sponsor:   Shanghai MicroPort Medical (Group) Co., Ltd.
Recruiting

Increasing Cardiac Rehabilitation Participation Among Medicaid Enrollees

Condition:   Coronary Artery Disease
Intervention:   Behavioral: Financial incentives
Sponsors:   University of Vermont;   National Institute of General Medical Sciences (NIGMS)
Completed

Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients

Conditions:   Frail Elderly;   Coronary Artery Disease
Interventions:   Procedure: Off-pump coronary-artery bypass grafting;   Procedure: On-pump coronary-artery bypass grafting
Sponsors:   University of Sao Paulo General Hospital;   Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina de São Paulo;   Instituto de Cardiologia do Distrito Federal;   Hospital Alberto Urquiza Wanderley;   Hospital das Clínicas Samuel Libânio;   Pontifícia Universidade Católica do Paraná;   Hospital Samaritano Paulista;   Beneficência Portuguesa de São Paulo;   Hospital Samaritano Campinas;   Mount Sinai Hospital, New York
Recruiting

Anatomical sNuffbox for Coronary anGiography and IntervEntions

Conditions:   Coronary Artery Disease;   Vascular Access Complication
Intervention:   Procedure: Coronary angiography +/- percutaneous coronary intervention
Sponsor:   University Hospital of Patras
Recruiting

Basel Stent Kosten Effektivitäts Trial Drug Eluting Balloons vs. Drug Eluting Stents in Small Vessel Interventions

Condition:   Coronary Heart Disease
Interventions:   Device: Drug eluting balloon;   Device: Drug eluting stent
Sponsors:   University Hospital, Basel, Switzerland;   Clinical Trial Unit, University Hospital Basel, Switzerland
Active, not recruiting

Comparison Three vs Twelve Months of Dual Anti-Platelet Therapy After Stent Implantation

Conditions:   Drug-Eluting Stents;   Percutaneous Coronary Intervention
Interventions:   Drug: 3 months DAPT;   Drug: 12 months DAPT
Sponsor:   Shanghai MicroPort Medical (Group) Co., Ltd.
Recruiting

The TransCatheter Valve and Vessels Trial

Conditions:   Aortic Stenosis;   Multi Vessel Coronary Artery Disease;   TAVI;   CABG;   PCI;   Fractional Flow Reserve
Interventions:   Device: FFR-guided PCI and TAVI;   Device: CABG and SAVR
Sponsors:   Maatschap Cardiologie Zwolle;   Medtronic
Recruiting

Disrupt CAD III With the Shockwave Coronary IVL System

Conditions:   Coronary Artery Disease;   Myocardial Infarction
Intervention:   Device: Lithotripsy
Sponsor:   Shockwave Medical, Inc.
Recruiting

PRehabilitiation in Elective Frail and Elderly Cardiac Surgery PaTients

Conditions:   Coronary Artery Disease;   Valvular Heart Disease
Interventions:   Behavioral: PREHAB Workshop;   Behavioral: PREHAB Exercise Program
Sponsor:   Ottawa Heart Institute Research Corporation
Withdrawn

Exercise in Patients With a Total Coronary Occlusion

Condition:   Coronary Occlusion
Intervention:   Other: Symptom limited cardiopulmonary exercise test & Sub-maximal cardiopulmonary exercise test
Sponsors:   University of Hull;   Sheffield Hallam University
Not yet recruiting

Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The ECLIPSE Trial

Conditions:   Coronary Artery Disease;   Ischemic Heart Disease;   Non ST Segment Elevation Myocardial Infarction
Interventions:   Device: Orbital Atherectomy;   Device: Balloon
Sponsors:   Cardiovascular Systems Inc;   Cardiovascular Research Foundation, New York
Recruiting

Aged Garlic Extract Study

Conditions:   Coronary Artery Disease;   Microcirculation;   Biomarkers
Interventions:   Dietary Supplement: Aged Garlic Extract;   Dietary Supplement: Placebo
Sponsor:   Lund University Hospital
Completed

Real Time Myocardial Perfusion Echocardiography for Coronary Allograft Vasculopathy

Condition:   Cardiac Allograft Vasculopathy
Interventions:   Drug: Perflutren Lipid Microsphere;   Procedure: RTMPE
Sponsors:   Mayo Clinic;   University of Calgary
Completed

Peer Support for Women With Heart Disease: Women@Heart

Conditions:   Coronary Heart Disease;   Women's Health
Intervention:   Behavioral: Women@Heart Program
Sponsor:   Ottawa Heart Institute Research Corporation
Recruiting

Clinical Outcomes in Patients Treated With SternaLock Blu

Conditions:   Cardiac Surgical Procedures;   Coronary Artery Disease;   Heart Valve Diseases
Intervention:   Device: SternaLock Blu
Sponsor:   Zimmer Biomet
Recruiting

Factors Affect Outcomes in Cardiovascular Surgery

Conditions:   Coronary Artery Disease;   Valvular Diseases;   Vascular Diseases
Intervention:  
Sponsor:   University of California, Davis
Recruiting

Proenkephalin for Prediction of Contrast-Associated Kidney Events

Conditions:   Contrast-induced Nephropathy;   Acute Kidney Injury;   Coronary Artery Disease
Intervention:   Diagnostic Test: blood-draw for biomarker analyses
Sponsor:   Dr. med. Mahir Karakas
Active, not recruiting

Chronic Total Occlusion Percutaneous Coronary Intervention Study

Conditions:   Chronic Total Occlusion;   Ischemic Heart Disease;   Chronic Total Occlusion of Coronary Artery
Interventions:   Procedure: Chronic Total Occlusion Revascularization;   Device: GuideLiner® V3 catheter, TrapLiner® catheter, Turnpike® catheter
Sponsors:   Vascular Solutions, Inc;   Teleflex;   Bright Research Partners
Not yet recruiting

BioFreedom QCA Study in CAD Patients

Conditions:   Coronary Artery Disease;   Cardiac Death;   Myocardial Infarction
Interventions:   Device: BioFreedom™ CoCr Biolimus A9™ stent;   Device: BioFreedom™ SS Biolimus A9™ stent
Sponsor:   Biosensors Europe SA
Active, not recruiting

Concordance Between FFR and iFR for the Assessment of Intermediate Lesions in the Left Main Coronary Artery. A Prospective Validation of a Default Value for iFR

Conditions:   Coronary Artery Disease;   Left Main Coronary Artery Stenosis;   Left Main Coronary Artery Disease;   Restenosis, Coronary
Intervention:   Other: Indication of revascularization
Sponsor:   Fundación EPIC
Recruiting

PGD2 Formation in Vascular Injury

Conditions:   Coronary Artery Disease;   Acute Coronary Syndrome;   Stable Angina
Interventions:   Drug: No ASA;   Drug: Low dose ASA;   Drug: 325 mg ASA
Sponsor:   University of Pennsylvania
Terminated

Assessing the Efficacy of CardiOGoniometry (CGM) to Localise the Culprit Vessel in Mixed Vessel Disease Non-ST elevatIon Myocardial infarcTION (NSTEMI)

Condition:   Acute Coronary Syndrome
Interventions:   Device: Cardiogoniometry;   Device: 12-lead ECG
Sponsor:   Hull and East Yorkshire Hospitals NHS Trust
Completed

Cardiovascular Events in Chronic Obstructive Pulmonary Disease Patients Initiating Olodaterol or Other Long-acting beta2 Agonists

Condition:   Pulmonary Disease, Chronic Obstructive
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Insulin Resistance and Atherosclerosis in Women With Lupus

Conditions:   Systemic Lupus Erythematosus;   Insulin Resistance;   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Completed

Myocardial Perfusion Imaging in Liver Transplantation Candidates

Conditions:   Myocardial Perfusion Imaging;   Liver Failure
Intervention:   Procedure: Myocardial perfusion imaging
Sponsor:   University Hospital Birmingham NHS Foundation Trust
Completed

Study of Dutogliptin in Combination With Filgrastim in Post-Myocardial Infarction

Conditions:   Acute Myocardial Infarction;   Acute Myocardial Ischemia;   STEMI - ST Elevation Myocardial Infarction
Interventions:   Drug: Dutogliptin Tartrate;   Drug: Filgrastim Injectable Product;   Drug: Placebos
Sponsor:   Recardio, Inc.
Enrolling by invitation

Effectiveness of Ranolazine on Reducing Chest Pain in Patients With Blockage But no Stents

Condition:   Angina
Interventions:   Drug: Ranolazine;   Drug: Sugar pill
Sponsors:   North Florida Foundation for Research and Education;   Gilead Sciences;   University of Florida
Terminated

Prediction and Prevention of Asymptomatic Cardiovascular Insult in Type 1 Diabetic Children: Comparative Effectiveness of Cardioprotective Drugs

Condition:   Diabetes Mellitus, Type 1
Interventions:   Drug: Atorvastatin;   Drug: Captopril;   Drug: L-carnitine
Sponsor:   Tanta University
Completed

Plasmonic Nanophotothermal Therapy of Atherosclerosis

Conditions:   Stable Angina;   Heart Failure;   Atherosclerosis;   Multivessel Coronary Artery Disease
Interventions:   Procedure: Transplantation of nanoparticles;   Procedure: Transplantation of iron-bearing nanoparticles;   Device: Stenting
Sponsors:   Ural Medical University;   Ural Institute of Cardiology;   De Haar Research Task Force;   Ural Federal University;   Transfiguration Clinic
Completed

Impact of Preoperative FFR on Arterial Bypass Graft Functionality

Condition:   Heart Disease
Intervention:   Procedure: Fractional Flow Reserve (FFR)
Sponsor:   Ottawa Heart Institute Research Corporation
Recruiting

Myocardial Infarction, COmbined-device, Recovery Enhancement Study

Conditions:   Acute Myocardial Infarction;   Coronary Artery Disease;   Acute Coronary Syndrome;   Myocardial Infarction
Intervention:   Device: Corrie Digital Health platform
Sponsors:   Johns Hopkins University;   Apple Inc.;   iHealth
Active, not recruiting

Hemodynamic Effects of Methylene Blue vs Hydroxocobalamin in Patients at Risk of Vasoplegia During Cardiac Surgery

Conditions:   Vasoplegia;   Hypotension;   Coronary Artery Disease;   Cardiac Valve Disease
Interventions:   Drug: Hydroxocobalamin;   Drug: Methylene Blue;   Drug: Normal saline
Sponsor:   Dartmouth-Hitchcock Medical Center
Not yet recruiting

Lipa Gene Mutation in PED-LIPIGEN (Pediatric FH Subjects)

Condition:   Lysosomal Acid Lipase Deficiency
Intervention:   Other: Observational study
Sponsor:   Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi)
Recruiting

Genetic Factors in Atherosclerosis

Condition:   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Completed

Switch to Ticagrelor in Critical Limb Ischemia Anti-platelet Study

Condition:   Critical Limb Ischemia
Intervention:   Drug: Ticagrelor
Sponsor:   University of Southern California
Completed

CTO Registry From Insight of IVUS in Fuwai Hospital

Conditions:   Coronary Heart Disease;   Chronic Total Occlusion of Coronary Artery;   Percutaneous Coronary Intervention;   Intravascular Ultrasound
Intervention:  
Sponsor:   China National Center for Cardiovascular Diseases
Recruiting

Genetically Determined Response to Atenolol in Patients With Persistent Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Drug: Atenolol
Sponsor:   Vanderbilt University Medical Center
Completed

Prospective Observational Epidemiologic Study of Maraviroc's Safety

Condition:   Human Immunodeficiency Virus
Interventions:   Drug: Maraviroc along with an optimized background antiretroviral drug regimen;   Drug: Optimized background antiretroviral drug regimen without maraviroc
Sponsors:   ViiV Healthcare;   Pfizer
Completed

Treatment of Erectile Dysfunction With Low-intensity Extracorporeal Shockwave Therapy

Condition:   Erectile Dysfunction Following Radiation Therapy
Intervention:   Device: low energy extracorporeal shockwave therapy
Sponsor:   National Taiwan University
Enrolling by invitation

Long Term Nitric Oxide Bioavailability on Vascular Health in Chronic Obstructive Pulmonary Disease

Condition:   Chronic Obstructive Pulmonary Disease (COPD)
Interventions:   Drug: Tetrahydrobiopterin (BH4);   Dietary Supplement: Antioxidant Cocktail
Sponsor:   Augusta University
Enrolling by invitation

Study of Abnormalities of the Nervous System in the Occurrence of Intradialytic Arterial Hypotension

Condition:   Hemodialysis Complication
Intervention:   Diagnostic Test: Cutaneous conductance to chlorine by SUDOSCAN
Sponsor:   Groupe Hospitalier Paris Saint Joseph
Not yet recruiting

Study to Evaluate Cinacalcet in Children With Chronic Kidney Disease

Conditions:   Chronic Kidney Disease;   Hyperparathyroidism, Secondary;   Secondary Hyperparathyroidism
Intervention:   Drug: Cinacalcet
Sponsor:   Amgen
Completed

Czech Multicentre Research Database of Chronic Obstructive Pulmonary Disease (COPD)

Condition:   Chronic Obstructive Airway Disease
Intervention:  
Sponsor:   Zuzana Zbožínková, M.Sc.
Active, not recruiting

Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

Conditions:   Healthy Volunteers and Subjects With Disease;   CAD
Interventions:   Device: MRI scan x 1- Healthy volunteer;   Device: MRI scan x 2- Healthy volunteer;   Device: MRI scan x 2- cardiac disease patients;   Device: MRI scan x 2- patients with non-cardiac disease
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Heart Function in Patients Assessed for Sleep Apnoea

Conditions:   Heart Failure With Preserved Ejection Fraction;   Sleep Disordered Breathing;   Heart Failure With Normal Ejection Fraction;   Obstructive Sleep Apnea;   Central Sleep Apnea;   Heart Failure
Intervention:  
Sponsors:   Imperial College London;   Royal Brompton & Harefield NHS Foundation Trust
Active, not recruiting

Aspirin in Preventing Recurrence of Cancer in Patients With HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy

Condition:   Node Positive HER2 Negative Breast Cancer
Interventions:   Other: Placebo;   Drug: Aspirin
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI);   United States Department of Defense;   Bayer;   Canadian Cancer Trials Group
Recruiting

Aclidinium Bromide Post-Authorisation Safety Study to Evaluate the Risk of Cardiovascular Endpoints

Condition:   Pulmonary Disease, Chronic Obstructive
Interventions:   Drug: Aclidinium bromide;   Drug: Other COPD medication
Sponsors:   AstraZeneca;   RTI Health Solutions
Recruiting

Technical Development of Cardiovascular Magnetic Resonance Imaging

Conditions:   Cardiomyopathy;   Congenital Heart Disease;   Cardiovascular Disease;   Cardiac Magnetic Resonance Imaging;   Acute Myocardial Infarction
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Suspended

EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality

Conditions:   Atrial Fibrillation;   Coronary Heart Disease;   Cardiovascular Diseases;   Heart Failure;   Hypertension;   Peripheral Arterial Disease;   Stroke, Ischemic;   Asthma;   Chronic Obstructive Pulmonary Disease;   Obesity;   Cancer;   Chronic Kidney Diseases;   Diabetes Mellitus;   Dementia;   Depression;   Epilepsy;   Mental Health Disorder;   Rheumatoid Arthritis;   Blood Pressure
Intervention:  
Sponsor:   Future Genetics Limited
Not yet recruiting

β Blocker Use and Mortality in Hospital Survivors of Acute Myocardial Infarction Without Heart Failure

Condition:   Acute Myocardial Infarction
Intervention:  
Sponsor:   University of Leeds
Completed

Safety of Terminating the Use of Aspirin After Left Atrial Appendage Closure

Condition:   Atrial Fibrillation
Intervention:   Drug: Termination of aspirin
Sponsor:   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Recruiting

Treat Stroke to Target

Conditions:   Ischemic Stroke;   Transient Ischemic Attack;   Atherosclerotic Stenosis
Interventions:   Procedure: Target : 100 mg/dL (+/-10 mg/dL);   Procedure: 70 mg/dL
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Pfizer;   AstraZeneca;   Merck Sharp & Dohme Corp.
Completed

An Observational Study of Natural History of Cardiovascular Diseases

Conditions:   Stroke;   Heart Attack;   TIA;   Cardiovascular Diseases
Intervention:  
Sponsors:   Imperial College London;   University of Oxford;   Clinical Trial Service Unit and Epidemiological Studies Unit
Completed

ACS Registry - A Non-interventional Study to Estimate the Rates of Outcomes in ACS Patients in Moscow

Conditions:   Heart Attack;   Stroke;   Cardiovascular Death
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Active, not recruiting

Research of Burden of Interstititial Lung Diseases in Turkey

Conditions:   Lung Diseases, Interstitial;   Fibrosis Lung
Intervention:  
Sponsor:   Karadeniz Technical University
Active, not recruiting

Singing Groups for Seniors: Well-Being, Cognitive Function and Health

Conditions:   Cognitive Function;   Well-Being;   Physical Function;   Respiratory Function;   Memory;   Biomarker;   Anxiety;   Depression;   Stress;   Quality of Life;   Loneliness;   Social Identification;   Blood Pressure;   Blood Glucose;   Cholesterol;   C-reactive Protein;   Erythrocyte Sedimentation Rate;   Balance;   Sleep;   Pain Perception;   Medication Compliance;   Health Complaint, Subjective;   Body Weight
Interventions:   Other: Singing Group Intervention Program;   Other: Alternative Social and Leisure Activities
Sponsors:   Iolanda Costa Galinha;   Direção Geral das Artes - DGArtes;   CIS-IUL - Centro de Investigação e de Intervenção Social, ISCTE
Enrolling by invitation

Adrecizumab in Cardiogenic Shock

Conditions:   Cardiogenic Shock;   Endothelial Dysfunction
Interventions:   Biological: Adrecizumab;   Drug: Placebo
Sponsor:   Dr. med. Mahir Karakas
Recruiting

Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Biological: Apolipoprotein A-I [human] (apoA-I);   Other: Placebo
Sponsor:   CSL Behring
Recruiting

Stress-Delta Biomarkers for Acute Coronary Syndrome Risk Stratification

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   Duke University
Active, not recruiting

Patients With Acute Myocardial Infarction

Condition:   Cardiovascular Diseases
Intervention:   Other: discharge training
Sponsor:   Celal Bayar University
Completed

Antiplatelet Therapy in Acute Coronary Syndrome(ACS). Safety and Efficacy of Switching Antiplatelet

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   Fundación Pública Andaluza Progreso y Salud
Active, not recruiting

Statins Evaluation in Coronary Procedures and Revascularization Trial

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Atorvastatin;   Drug: Placebo
Sponsors:   Hospital do Coracao;   Ministry of Health, Brazil
Completed

Ultrasound Study of the Diaphragm Evolution Under ECMO

Conditions:   Cardiogenic Shock;   Weaning Failure
Intervention:  
Sponsor:   Association Pro-arte
Completed

North American Acute Coronary Syndrome (ACS) Reflective III Pilot

Conditions:   Dyslipidemias;   Acute Coronary Syndrome
Intervention:   Other: Guideline recommended feedback
Sponsors:   Canadian Heart Research Centre;   Sanofi
Enrolling by invitation

EARLY-MYO-CMR-II Registry

Condition:   Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
Intervention:  
Sponsor:   RenJi Hospital
Recruiting

Physiology & Optical Coherence in STEMI

Condition:   Myocardial Infarction
Intervention:   Procedure: function or imaging guided PCI
Sponsor:   Shenyang Northern Hospital
Not yet recruiting

Efficacy, Safety and Tolerability of ATH3G10 in Patients With ST-elevation Myocardial Infarction

Condition:   ST Elevation Myocardial Infarction
Interventions:   Drug: ATH3G10;   Drug: Placebo
Sponsor:   Athera Biotechnologies AB
Recruiting

The Acute and Chronic Effects of Remote Ischemic Conditioning on Cardiovascular Function

Condition:   Acute Myocardial Infarction
Intervention:   Device: Brachial cuff, in order to achieve ischemic stimuli
Sponsor:   University of Athens
Active, not recruiting

The Predictive Value of eGFR for Adverse Cardiovascular Events in Patients With STEMI

Condition:   ST Elevation Myocardial Infarction
Intervention:  
Sponsor:   Dongying Zhang
Completed

Metformin Continuation Versus Interruption Following Coronary Angiography: a Pilot Randomized Controlled Trial

Conditions:   Acute Coronary Syndrome;   Unstable Angina;   Diabetes Mellitus;   Metformin Adverse Reaction
Intervention:   Drug: Metformin
Sponsor:   University of Saskatchewan
Recruiting

Smart Device-based Cardiac Rehabilitation After Myocardial Intervention

Condition:   Myocardial Infarction
Intervention:   Device: Smart device-based cardiac rehabilitation
Sponsors:   Charles University, Czech Republic;   Institute for Clinical and Experimental Medicine
Recruiting

Early Assessment of QFR in STEMI-II

Condition:   ST Segment Elevation Myocardial Infarction
Intervention:   Diagnostic Test: Computation of quantitative flow ratio
Sponsor:   RenJi Hospital
Recruiting

Bivalirudin With Prolonged Full Dose Infusion Versus Heparin Alone During Emergency PCI

Condition:   ST Elevation Myocardial Infarction
Interventions:   Drug: Bivalirudin;   Drug: unfractionated Heparin
Sponsor:   Shenyang Northern Hospital
Recruiting

EARLY-MYO-CMR Registry

Condition:   ST-segment Elevation Myocardial Infarction (STEMI)
Intervention:  
Sponsor:   RenJi Hospital
Recruiting

Early Alirocumab to Reduce LDL-C in Myocardial Infarction

Conditions:   Myocardial Infarction;   Dyslipidemias
Interventions:   Drug: Alirocumab;   Drug: Atorvastatin 80mg;   Drug: Ezetimibe 10mg
Sponsors:   Imperial College London;   Regeneron Pharmaceuticals;   Baim Institute for Clinical Research
Withdrawn

Firibastat or Ramipril After Acute Myocardial Infarction for Prevention of Left Ventricular Dysfunction

Condition:   Myocardial Infarction
Interventions:   Drug: Ramipril;   Drug: Firibastat
Sponsor:   Quantum Genomics SA
Recruiting

Comparison of Anticoagulation Prolongation vs. no Anticoagulation in STEMI Patients After Primary PCI

Condition:   STEMI - ST Elevation Myocardial Infarction
Interventions:   Drug: Bivalirudin;   Drug: Enoxaparin;   Drug: Unfractionated heparin;   Drug: Bivalirudin placebo;   Drug: Enoxaparin placebo syringe;   Drug: Unfractionated heparin placebo
Sponsors:   Beijing Anzhen Hospital;   Chinese Academy of Medical Sciences, Fuwai Hospital;   ACTION Study Group (Pitié-Salpêtrière Hospital), Paris, France
Recruiting

A Study to Evaluate the Safety and Efficacy of MEDI6012 in Acute ST Elevation Myocardial Infarction

Condition:   ST Elevation Myocardial Infarction
Interventions:   Biological: MEDI6012;   Other: Placebo
Sponsors:   MedImmune LLC;   Thrombolysis in Myocardial Infarction (TIMI) Study Group
Recruiting

Brilinta Clinical Experience Investigation

Condition:   Acute Coronary Syndrome, Old Myocardial Infarction
Intervention:  
Sponsor:   AstraZeneca
Recruiting

The Incidence, Effect and Persistence of Fragmented-QRS, in Patients Presenting With ST-Elevation Myocardial Infarction

Condition:   ST Elevation Myocardial Infarction
Intervention:  
Sponsor:   The Royal Wolverhampton Hospitals NHS Trust
Completed

EROSION II: OCT Guided PPCI in STEMI

Condition:   STEMI - ST Elevation Myocardial Infarction
Intervention:  
Sponsors:   Harbin Medical University;   Shenzhen Salubris Pharmaceuticals Co., Ltd. (Salubris);   CCRF
Recruiting

Quality and Safety of Initial Management for ST-segment Elevation Myocardial Infarction

Condition:   Myocardial Infarction
Intervention:   Other: Daily practice care for patients with suspected of STEMI
Sponsors:   Centre Hospitalier de la Région d'Annecy;   University Hospital, Grenoble
Recruiting

Guideline Recommended Care and Excess Mortality for Non ST-elevation Myocardial Infarction : A National Cohort Study

Condition:   Non ST-elevation Myocardial Infarction
Intervention:  
Sponsor:   University of Leeds
Completed

BIO monitorinG in Patients With Preserved Left ventricUlar Function AfteR Diagnosed Myocardial Infarction

Conditions:   Myocardial Infarction;   Myocardial Infarction, Acute;   Myocardial Infarction Old
Intervention:   Device: BioMonitor
Sponsor:   Biotronik SE & Co. KG
Recruiting

Iron in Patients With Cardiovascular Disease

Conditions:   Cardiovascular Diseases;   Anemia, Iron-deficiency;   Acute Myocardial Infarction;   Atrial Fibrillation;   Systolic Heart Failure
Interventions:   Drug: Ferric carboxymaltose;   Drug: Saline
Sponsor:   Dr. med. Mahir Karakas
Recruiting

Utilising Lifemap to Investigate Malignant Arrhythmia Therapy

Conditions:   Ischemic Cardiomyopathy;   Sudden Cardiac Death;   Implantable Defibrillator User;   Myocardial Infarction;   Arrhythmias, Cardiac
Intervention:  
Sponsors:   University Hospitals, Leicester;   University of Leicester
Recruiting

Efficacy and Safety Evaluation of PC-SOD for Injection in Reducing Myocardial Reperfusion Injury

Condition:   Myocardial Reperfusion Injury
Interventions:   Drug: PC-SOD;   Drug: placebo
Sponsors:   Beijing Tide Pharmaceutical Co., Ltd;   Peking University First Hospital
Not yet recruiting

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Conditions:   Acute Coronary Syndrome;   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting