Coronary Artery Disease

Clinical Trial Finder

Many patients with coronary artery disease are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Myocardial Flow Reserve and 99mTc-DTPA Cardiac Dynamic SPECT

Condition:   Coronary Artery Disease
Intervention:   Other: Cardiac SPECT
Sponsor:   University Hospital, Caen
Not yet recruiting - verified July 2016

Influence of Different Forms of Exercise Training in Patients With Coronary Artery Disease

Condition:   Coronary Artery Disease
Interventions:   Other: water-based exercise training;   Other: land-based exercise training
Sponsors:   University Medical Centre Ljubljana;   KRKA
Recruiting - verified July 2016

High Intensity Lipid Lowering Following Acute Coronary Syndromes for Persons Living With HIV

Conditions:   HIV Infection;   Coronary Heart Disease
Interventions:   Drug: Pravastatin;   Drug: Rosuvastatin
Sponsor:   Donald Lloyd-Jones
Not yet recruiting - verified July 2016

Galaxy Rapamycin Drug-Eluting Bioresorbable Coronary Stent System First-in-man Study

Condition:   Heart Diseases
Intervention:   Device: Rapamycin Drug-Eluting Bioresorbable Coronary Stent System
Sponsor:   Shanghai Bio-heart Biological Technology Co., Ltd.
Not yet recruiting - verified July 2016

3-Month Discontinuation of Dual Antiplatelet Therapy After Ultimaster Sirolimus-Eluting Stent Implantation

Condition:   Coronary Artery Disease
Interventions:   Drug: Aspirin;   Drug: Thienopyridine
Sponsor:   Teikyo University
Not yet recruiting - verified July 2016

Long-term Remote Ischemic Preconditioning Improve Long-term Prognosis of Acute Myocardial Infarction Patients Without Emergency Reperfusion Therapy

Condition:   Myocardial Infarction [C14.280.647.500]
Intervention:   Other: reported remote ischemic preconditioning (RIPC)
Sponsor:   Xuanwu Hospital, Beijing
Not yet recruiting - verified July 2016

Reactive Oxygen Species Following Aortic Valve Replacement

Condition:   Aortic Stenosis
Intervention:  
Sponsor:   University Hospital Southampton NHS Foundation Trust.
Recruiting - verified July 2016

Evaluation of Soluble ST2 in Patients Receiving Primary PCI With ST-elevation Myocardial Infarction

Conditions:   Myocardial Infarction;   Shock
Intervention:  
Sponsor:   Wuhan Asia Heart Hospital
Recruiting - verified July 2016

Moderato System: A Double-Blind Randomized Trial

Conditions:   Hypertension Resistant to Conventional Therapy;   Bradycardia;   Atrioventricular Block
Interventions:   Device: BackBeat-PHC ON;   Device: BackBeat-PHC OFF
Sponsor:   BackBeat Medical Inc
Recruiting - verified July 2016

SYNTAX III REVOLUTION Trial: A Randomized Study Investigating the Use of CT Scan and Angiography of the Heart to Help the Doctors Decide Which Method is the Best to Improve Blood Supply to the Heart in Patients With Complex Coronary Artery Disease

Conditions:   Coronary Artery Diseases;   Multivessel Coronary Artery Disease;   Heart Diseases;   Cardiovascular Diseases
Interventions:   Radiation: Coronary Angiography;   Radiation: Computed Tomography (CT) scan
Sponsors:   ECRI bv;   GE Healthcare;   HeartFlow, Inc.
Not yet recruiting - verified July 2016

Retrospective Study of Acute Chest Pain in Extremely Critical Condition for More Than Ten Years

Conditions:   Acute Myocardial Infarction;   Pulmonary Embolism;   Aortic Dissection
Intervention:  
Sponsor:   Qilu Hospital
Recruiting - verified July 2016

Increasing Risk Perception of Physical Activity Using Patient-targeted Feedback.

Conditions:   Hypertension;   Coronary Disease;   Cardiac Diseases
Interventions:   Behavioral: Patient-targeted individual physical-activity-feedback;   Device: Pedometer
Sponsor:   Universitätsklinikum Hamburg-Eppendorf
Not yet recruiting - verified July 2016

Ad-HGF Treatment for Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Drug: Ad-HGF;   Other: 0.9% NaCl
Sponsor:   The First Affiliated Hospital with Nanjing Medical University
Not yet recruiting - verified June 2016

Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension

Condition:   Hypertension Resistant to Conventional Therapy
Interventions:   Drug: Spironolactone;   Drug: Furosemide,;   Drug: Amiloride;   Drug: Ramipril;   Drug: Bisoprolol
Sponsor:   Sao Jose do Rio Preto University
Recruiting - verified July 2016

The Efficacy and Safety of rhTNK-tPA in Comparison With Alteplase(Rt-PA) as Fibrinolytic Therapy of Acute STEMI

Condition:   Acute ST Elevation Myocardial Infarction
Interventions:   Drug: rhTNK-tPA;   Drug: alteplase
Sponsors:   Guangzhou Recomgen Biotech Co., Ltd.;   Chinese Academy of Medical Sciences, Fuwai Hospital;   Peking University
Active, not recruiting - verified July 2016

TIBOHCA: Safety, Tolerability and Pharmacokinetics of 2-Iminobiotin (2-IB) After OHCA

Conditions:   Cardiac Arrest;   Hypoxic Ischemic Brain Injury
Intervention:   Drug: 2-Iminobiotin
Sponsor:   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Recruiting - verified July 2016

Intra-patient Study With Polymer Free Drug Eluting Stent Versus Abluminal Biodegradable Polymer Drug Eluting Stent With Early OCT (Optical Coherence Tomography) Follow up

Condition:   Coronary Artery Disease
Interventions:   Device: Coroflex® ISAR Drug-eluting stent;   Device: Ultimaster® Drug-eluting stent
Sponsors:   Hospital Universitari Vall d'Hebron Research Institute;   B.Braun Surgical SA
Recruiting - verified July 2016

Investigating the Effects of Cardiac Rehabilitation eXercise Modalities on Physical and Mental Health Outcomes

Condition:   Coronary Artery Disease (CAD)
Interventions:   Behavioral: High Intensity Interval Training;   Behavioral: Moderate Intensity Continuous Exercise Training;   Behavioral: Nordic Walking
Sponsors:   Ottawa Heart Institute Research Corporation;   Ontario Ministry of Health and Long Term Care;   Heart and Stroke Foundation of Canada
Recruiting - verified July 2016

Circulating PRCP in STEMI Patients Undergoing Primary PCI

Conditions:   Myocardial Infarction;   Percutaneous Coronary Intervention;   PRCP
Intervention:   Procedure: Primary PCI
Sponsor:   Qilu Hospital
Completed - verified July 2016

Circulatory Oscillations in Post Cardiac Surgery Patients

Condition:   Coronary Disease
Intervention:   Procedure: Heart surgery
Sponsors:   St. Olavs Hospital;   Norwegian University of Science and Technology
Recruiting - verified July 2016

Clinical Study of Medicinal Product Cardionat® Using in Health Athlete Volunteers

Conditions:   Stroke, Not Specified as Hemorrhage or Infarction;   Angina Pectoris
Intervention:   Drug: оral intake of study drug capsules; study drug - Cardionat ® (trimethylhydrazinium propionate dihydrate), oral capsules 250 mg
Sponsor:   Burnasyan Federal Medical Biophysical Center
Recruiting - verified April 2016

A Study of CSL112 in Adults With Moderate Renal Impairment and Acute Myocardial Infarction

Condition:   Acute Myocardial Infarction
Interventions:   Biological: CSL_112;   Other: Placebo
Sponsor:   CSL Behring
Not yet recruiting - verified July 2016

IRIS-BVS AMI Registry

Conditions:   Arterial Occlusive Diseases;   Cardiovascular Diseases;   Coronary Artery Disease
Intervention:   Device: Bioresorbable Vascular Scaffold
Sponsors:   CHEOL WHAN LEE, M.D., Ph.D;   CardioVascular Research Foundation, Korea
Recruiting - verified July 2016

FGF21 Can Help Predicting Arterial Stiffness Measured by Cardio-ankle Vascular Index in Renal Transplant Patients

Condition:   Vascular Stiffness
Intervention:   Other: CAVI and FGF-21
Sponsor:   Bangkok Metropolitan Administration Medical College and Vajira Hospital
Completed - verified July 2016

PARA-HEART Pilot Implementation

Conditions:   Acute Coronary Syndrome;   Chest Pain
Intervention:  
Sponsor:   Wake Forest Baptist Health
Not yet recruiting - verified July 2016

Mental Stress Ischemia: Biofeedback Study

Conditions:   Cardiovascular Disease;   Coronary Artery Disease
Interventions:   Behavioral: Heart Rate Variability (HRV) Biofeedback (BF);   Other: Mental Stress Protocol
Sponsor:   Emory University
Recruiting - verified July 2016

Fractional FLow Reserve And IVUS for Clinical OUtcomes in Patients With InteRmediate Stenosis

Condition:   Stable Angina
Intervention:   Device: Drug-eluting stent
Sponsors:   Seoul National University Hospital;   Ajou University School of Medicine;   Keimyung University Dongsan Medical Center;   Inje University
Recruiting - verified July 2016

Fractional Flow Reserve Versus Angiography for Guiding Selective Percutaneous Coronary Intervention in ST-segment Elevation Myocardial Infarction

Conditions:   Fractional Flow Reserve;   ST-segment Elevation Myocardial Infarction;   Percutaneous Coronary Intervention
Intervention:  
Sponsor:   Nanjing Medical University
Enrolling by invitation - verified January 2016

Comparative Effectiveness of Decision Aids for Stable Chest Discomfort

Conditions:   Coronary Artery Disease;   Stable Angina
Interventions:   Behavioral: Online decision aid;   Behavioral: Video decision aid
Sponsor:   Massachusetts General Hospital
Active, not recruiting - verified July 2016

Remote Ischaemic Conditioning and Coronary Endothelial Function (RIC-COR)

Conditions:   Ischemic Preconditioning;   Coronary Disease
Interventions:   Procedure: Remote ischaemic conditioning;   Procedure: Arm cuff placement, no inflation;
Sponsors:   NHS National Waiting Times Centre Board;   University of Glasgow;   Chest, Heart and Stroke Association Scotland;   Chief Scientist Office of the Scottish Government
Completed - verified July 2016

Short-term Air Pollution Exposure and In-hospital Outcomes in Patients With Acute Myocardial Infraction

Conditions:   Air Pollution;   Acute Myocardial Infarction;   Percutaneous Coronary Intervention
Intervention:  
Sponsors:   Nanjing Medical University;   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Enrolling by invitation - verified July 2016

Vericiguat Drug-drug Interaction With Nitroglycerin in Stable Coronary Artery Disease Patients

Condition:   Coronary Artery Disease
Interventions:   Drug: Vericiguat (BAY1021189);   Drug: Placebo;   Drug: Nitroglycerin
Sponsors:   Bayer;   Merck Sharp & Dohme Corp.
Recruiting - verified July 2016

Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics, of MEDI6012 in Subjects With Stable Coronary Artery Disease

Condition:   Coronary Artery Disease
Interventions:   Biological: MEDI6012;   Biological: Placebo
Sponsor:   MedImmune LLC
Recruiting - verified July 2016

"Me and My Heart" Study

Condition:   Acute Coronary Syndrome
Interventions:   Device: Active group with MEMS;   Device: Active group without MEMS;   Device: Control group with MEMS;   Device: Control group without MEMS
Sponsor:   AstraZeneca
Recruiting - verified July 2016

Effect of RVX000222 on Time to Major Adverse Cardiovascular Events in High-Risk T2DM Subjects With CAD

Conditions:   Diabetes Mellitus, Type 2;   Coronary Artery Disease;   Cardiovascular Diseases
Interventions:   Drug: RVX000222;   Drug: Placebo (for RVX000222);   Drug: atorvastatin;   Drug: rosuvastatin
Sponsors:   Resverlogix Corp;   PPD;   ICON plc;   Medidata Solutions
Recruiting - verified July 2016

Analysis of Surface EKG Signals to Identify Myocardial Dysfunction in Patients at Risk for Coronary Artery Disease

Condition:   Coronary Artery Disease
Interventions:   Device: MyoVista device;   Device: Computed tomographic coronary angiography;   Device: Transthoracic Echocardiography
Sponsors:   Icahn School of Medicine at Mount Sinai;   Heart Test Laboratories Inc.
Recruiting - verified July 2016

Peripheral Chemoreflex/Arterial Baroreflex Interaction in Patients With Electrical Carotid Sinus Stimulation

Condition:   Hypertension, Resistant to Conventional Therapy
Interventions:   Other: Hypoxia without dopamine;   Other: Hypoxia with dopamine;   Other: Hyperoxia without dopamine;   Other: Hyperoxia with dopamine
Sponsors:   Hannover Medical School;   Charite University, Berlin, Germany;   Vanderbilt University School of Medicine;   Mayo Clinic;   University of Bristol
Recruiting - verified October 2015

Treadmill CV Safety Study

Condition:   Stable Angina
Interventions:   Drug: AMG 334;   Drug: Placebo
Sponsor:   Amgen
Recruiting - verified July 2016

Epidemiological Study on the Safety of Aspirin in The Health Improvement Network (THIN)

Conditions:   Secondary Prevention;   Stroke;   Ischemic Heart Disease;   Coronary Heart Disease
Interventions:   Drug: Acetylsalicylic Acid (Asprin, BAYE4465);   Drug: Clopidogrel, Oral Anticoagulants, NSAIDs and SSRIs
Sponsor:   Bayer
Recruiting - verified July 2016

Evaluation of Safety and Efficacy of Lumason/SonoVue in Subjects Undergoing Pharmacologic Stress BR1-142

Condition:   Coronary Artery Disease
Intervention:   Drug: sulphur hexafluoride lipid-type A microspheres
Sponsor:   Bracco Diagnostics, Inc
Recruiting - verified July 2016

ComparisoN of ticAgrelor vs. Clopidogrel in endoTHeliAl Function of COPD patieNts

Conditions:   Coronary Artery Disease;   Chronic Obstructive Pulmonary Disease
Interventions:   Drug: Aspirin 100 mg;   Drug: Ticagrelor;   Drug: Clopidogrel
Sponsor:   University Hospital of Ferrara
Active, not recruiting - verified May 2016

Comparison of a CrossBoss First Versus Standard Wire Escalation Strategy for Crossing Coronary Chronic Total Occlusion: the "CrossBoss First" Trial

Conditions:   Arteriosclerosis;   Coronary Artery Disease;   Myocardial Ischemia;   Coronary Disease
Interventions:   Procedure: CrossBoss Catheter;   Procedure: Antegrade Wire Escalation Strategy
Sponsors:   North Texas Veterans Healthcare System;   Henry Ford Hospital;   Massachusetts General Hospital;   North Central Heart-Avera Sacred Heart Hospital;   Saint Lukes Hospital Mid America Heart Institute;   Missouri Heart Center;   University of Washington
Enrolling by invitation - verified July 2016

Evaluation of Safety and Efficacy of Lumason/SonoVue in Subjects Undergoing Pharmacologic Stress BR1-141

Condition:   Coronary Artery Disease
Intervention:   Drug: sulphur hexafluoride lipid-type A microspheres
Sponsor:   Bracco Diagnostics, Inc
Recruiting - verified July 2016

Exercise and Pharmacotherapy for Anxiety in Cardiac Patients

Conditions:   Anxiety;   Cardiovascular Disease
Interventions:   Drug: Lexapro;   Drug: Placebo;   Behavioral: Supervised Aerboic Exercise
Sponsor:   Duke University
Recruiting - verified July 2016

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Recruiting - verified July 2016

Smartphone Twelve Lead Electrocardiogram Utility In ST-Elevation Myocardial Infarction

Condition:   ST Segment Elevation Myocardial Infarction
Intervention:  
Sponsor:   Intermountain Health Care, Inc.
Recruiting - verified June 2016

Stress Ulcer Prophylaxis in the Intensive Care Unit

Conditions:   Gastrointestinal Bleeding;   Stress Ulcers
Interventions:   Drug: Pantoprazole;   Other: Saline (0.9%)
Sponsors:   Dr. Morten Hylander Møller;   Rigshospitalet, Denmark;   Copenhagen Trial Unit, Center for Clinical Intervention Research
Recruiting - verified July 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsor:   Bayer
Recruiting - verified July 2016

Affordability and Real-world Antiplatelet Treatment Effectiveness After Myocardial Infarction Study

Condition:   Cost Sharing, Acute Coronary Syndrome,
Intervention:   Other: Study voucher card
Sponsors:   AstraZeneca;   Duke Clinical Research Institute
Recruiting - verified July 2016

Safety and Effectiveness of the Orsiro Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions

Conditions:   Coronary Artery Disease;   Atherosclerosis, Coronary;   Myocardial Ischemia;   Ischemic Heart Disease;   Acute Coronary Syndrome;   Angina Pectoris
Interventions:   Device: Orsiro DES;   Device: Xience DES
Sponsors:   Biotronik, Inc.;   Biotronik AG;   Harvard Clinical Research Institute;   Medstar Research Institute
Active, not recruiting - verified July 2016

Validation of Simple Acute Coronary Syndrome (SACS) Score

Conditions:   Chest Pain;   Acute Coronary Syndrome;   Angina;   Myocardial Infarction
Intervention:  
Sponsors:   Bayfront Health St Petersburg;   Bayfront Health Dade City;   Community Health Systems (CHS)
Enrolling by invitation - verified July 2016

The Health Impact of High Intensity Exercise Training With Intervals During Cardiac Rehabilitation

Conditions:   Heart Disease;   Heart Attacks
Interventions:   Other: High intensity interval training (HIIT);   Other: Standard care
Sponsors:   Liverpool Heart and Chest Hospital NHS Foundation Trust;   Edge Hill University
Recruiting - verified July 2016

Statins at the Primary Care Level

Condition:   Dyslipidemia
Intervention:   Other: Educational Intervention
Sponsor:   Institute for Clinical Effectiveness and Health Policy
Active, not recruiting - verified July 2016

China PEACE II: Quality Improvement for Acute Myocardial Infarction

Condition:   Acute Myocardial Infarction
Interventions:   Behavioral: Quality improvement strategies and tools;   Behavioral: Process optimization
Sponsor:   China National Center for Cardiovascular Diseases
Active, not recruiting - verified July 2016

Combined Coronary and Cerebral Angiography and Intervention for Coronary and Cerebrovascular Atherosclerosis

Conditions:   Coronary Stenosis;   Cerebral Stenosis
Interventions:   Other: simultaneous coronary and cerebral intervention;   Other: staged coronary and cerebral intervention
Sponsor:   Capital Medical University
Recruiting - verified July 2016

A High-Resolution Magnetic Resonance Imaging Study to Evaluate the Effect of Rosuvastatin on Carotid Atherosclerotic Plaques

Conditions:   Arteriosclerosis;   Diabetes Mellitus;   Lipid Disorder
Interventions:   Drug: Rosuvastatin 5mg;   Drug: Rosuvastatin 20mg
Sponsor:   Capital Medical University
Recruiting - verified July 2016

Sonolysis in Risk Reduction of Symptomatic and Silent Brain Infarctions During Coronary Stenting

Condition:   Coronary Artery Disease
Interventions:   Device: Sonolysis;   Other: Sham procedure
Sponsor:   University Hospital Ostrava
Recruiting - verified July 2016

ILUMIEN III: OPTIMIZE PCI

Condition:   Coronary Artery Disease
Interventions:   Procedure: Coronary PCI guided by IVUS;   Procedure: Coronary PCI guided by OCT;   Procedure: Coronary PCI guided by Angiography
Sponsors:   St. Jude Medical;   Cardiovascular Research Foundation, New York
Active, not recruiting - verified July 2016

CCC Project- Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsors:   Beijing Institute of Heart, Lung and Blood Vessel Diseases;   American Heart Association;   Chinese Society of Cardiology
Recruiting - verified July 2016

A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Acetylsalicylic acid;   Drug: Rivaroxaban;   Drug: Clopidogrel;   Drug: Ticagrelor
Sponsors:   Janssen Research & Development, LLC;   Bayer;   Duke Clinical Research Institute;   Harvard Medical School
Recruiting - verified July 2016

Safety and Performance Study of the Moderato System

Conditions:   Hypertension Resistant to Conventional Therapy;   Bradycardia;   Atrioventricular Block
Intervention:   Device: The Moderato System
Sponsor:   BackBeat Medical Inc
Active, not recruiting - verified July 2016

REWARDS Premier Taxus-Liberte vs Xience V

Condition:   Coronary Artery Disease
Intervention:   Other: Observational
Sponsor:   Medstar Research Institute
Completed - verified July 2016

Extension (OLE) Study to Assess Safety and Efficacy of Evolocumab

Condition:   Hypercholesterolemia
Intervention:   Biological: Evolocumab
Sponsor:   Amgen
Enrolling by invitation - verified July 2016

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified July 2016

REPARA Study: REgistry of PAtients With bioResorbable Device in Daily Clinical prActice

Condition:   Coronary Artery Lesions With Implantation of Coronary Device
Intervention:  
Sponsor:   Sección Hemodinamica y Cardiologia Intervencionista
Active, not recruiting - verified July 2016

Dexmedetomidine and Outcomes of Cardiac Surgery (DOCS)

Conditions:   Heart Valve Diseases;;   Cardiac Valve Replacement Complication;;   Coronary Artery Disease
Interventions:   Drug: dexmedetomidine;   Drug: placebo
Sponsor:   Xijing Hospital
Recruiting - verified July 2016

Prospective, Single-arm, Multi Centre Observations Ultimaster Des Registry

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   Terumo Europe N.V.
Recruiting - verified July 2016

Vegan vs AHA Diet on Inflammation and Glucometabolic Profile in Patients With CAD

Conditions:   Coronary Artery Disease;   Inflammation
Intervention:   Behavioral: Diet
Sponsor:   New York University School of Medicine
Recruiting - verified July 2016

Research of Resistance to Antiplatelet Agents and Development of Tailored Treatment Model for Patients With Coronary Artery Disease

Conditions:   Cardiovascular Diseases;   Coronary Artery Disease
Intervention:  
Sponsor:   Young-Hak Kim, MD, PhD
Recruiting - verified July 2016

Rubidium Elution System Performance Testing

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   Ottawa Heart Institute Research Corporation;   Jubilant DraxImage Inc.
Recruiting - verified July 2016

Characterization of Changes in Ventricular Mechanics in Response to Lexiscan Stress Using Tagged Cine Cardiac Magnetic Resonance Imaging

Condition:   Coronary Artery Disease
Intervention:   Drug: Regadenoson
Sponsors:   Timothy M. Bateman;   Saint Luke's Health System;   Saint Luke's Cardiovascular Consultants
Recruiting - verified July 2016

Obtain Additional Information on Use of CorMatrix ECM (Extracellular Matrix)

Condition:   Coronary Disease
Intervention:  
Sponsor:   CorMatrix
Enrolling by invitation - verified July 2016

IRIS-PREMIER REGISTRY

Conditions:   Coronary Artery Disease;   Myocardial Ischemia;   Coronary Disease;   Heart Diseases
Intervention:   Device: Promus PREMIER
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea;   Boston Scientific Korea Co. Ltd
Active, not recruiting - verified July 2016

Detection and Significance of Heart Injury in ST Elevation Myocardial Infarction.

Condition:   Acute ST-elevation Myocardial Infarction
Interventions:   Device: Coronary pressure wire;   Other: Magnetic resonance imaging of the heart
Sponsors:   NHS National Waiting Times Centre Board;   Siemens Healthcare Diagnostics Inc;   British Heart Foundation
Active, not recruiting - verified July 2016

Study of Effects of Ticagrelor on Microparticles and Micro-RNA in NSTE-ACS

Condition:   Non ST Segment Elevation Acute Coronary Syndrome
Interventions:   Drug: Ticagrelor;   Drug: Clopidogrel
Sponsor:   Catholic University of the Sacred Heart
Terminated - verified July 2016

Ticagrelor Antiplatelet Therapy to Reduce Graft Events and Thrombosis

Condition:   Saphenous Vein Graft Disease
Interventions:   Drug: Aspirin;   Drug: Ticagrelor
Sponsors:   Boca Raton Regional Hospital;   AstraZeneca;   Ottawa Heart Institute Research Corporation
Recruiting - verified July 2016

Verification of the Safety of Early Discharge in Patients After Acute ST-segment Myocardial Infarction

Conditions:   Coronary Artery Disease;   Acute Myocardial Infarction With ST-segment Elevation;   Primary Percutaneous Coronary Intervention;   Early Discharge
Interventions:   Other: Early discharge;   Other: Standard discharge
Sponsor:   Kamil Novobílský
Recruiting - verified July 2016

STem cElls Mobilization in Acute Myocardial Infarction Outcome Trial

Conditions:   Anterior Acute Myocardial Infarction;   Left Ventricular Systolic Dysfunction
Intervention:   Drug: G-CSF administration
Sponsors:   Heart Care Foundation;   A. Manzoni Hospital;   Centro Cardiologico Monzino
Suspended - verified March 2015

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxoban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsor:   Bayer
Recruiting - verified July 2016

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Germany)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsor:   Bayer
Recruiting - verified July 2016

Study of Efficacy and Safety of Percutaneous Coronary Intervention to Improve Survival in Heart Failure

Condition:   Ischemic Cardiomyopathy
Interventions:   Procedure: Percutaneous Coronary Intervention;   Drug: Drug Therapy for Heart Failure;   Device: Device Therapy for Heart Failure
Sponsors:   King's College London;   National Institute for Health Research, United Kingdom;   London School of Hygiene and Tropical Medicine (Clinical Trials Unit);   University of York;   Guy's and St Thomas' NHS Foundation Trust
Recruiting - verified July 2016

Gadobutrol / Gadavist-enhanced Cardiac Magnetic Resonance Imaging (CMRI) to Detect Coronary Artery Disease (CAD)

Condition:   Coronary Artery Disease
Intervention:   Drug: Gadobutrol (Gadovist, BAY86-4875)
Sponsor:   Bayer
Recruiting - verified July 2016

OPtical Frequency Domain Imaging Versus INtravascular Ultrasound in Percutaneous Coronary InterventiON - OPINION Imaging

Condition:   Coronary Artery Disease
Interventions:   Device: OFDI-guided PCI & IVUS;   Device: IVUS-guided PCI & OFDI
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Wakayama Medical University
Completed - verified July 2016

OPtical Frequency Domain Imaging vs. INtravascular Ultrasound in Percutaneous Coronary InterventiON

Condition:   Coronary Artery Disease
Interventions:   Device: OFDI;   Device: IVUS
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Wakayama Medical University
Completed - verified July 2016

Conservative Non-Invasive Versus Routine Invasive Management in Coronary Artery Bypass Surgery Patients With Non ST Elevation Elevation Acute Coronary Syndrome

Conditions:   Non ST Elevation Myocardial Infarction;   Unstable Angina
Intervention:   Procedure: Invasive management
Sponsors:   NHS National Waiting Times Centre Board;   University of Glasgow
Completed - verified July 2016

Chronic Remote Ischemic Conditioning to Modify Post-MI Remodeling

Condition:   Myocardial Infarction
Intervention:   Device: Auto Remote Ischemic Conditioning (AutoRIC) device
Sponsors:   The Hospital for Sick Children;   University Health Network, Toronto;   Sunnybrook Health Sciences Centre;   St. Michael's Hospital, Toronto
Recruiting - verified July 2016

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention &Amp; Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute
Recruiting - verified July 2016

Fractional Flow Reserve Versus Angiographically Guided Management to Optimise Outcomes in Unstable Coronary Syndromes

Conditions:   Non-ST Elevation Myocardial Infarction.;   Type 1 Myocardial Infarction.
Intervention:   Device: Fractional flow reserve
Sponsors:   NHS National Waiting Times Centre Board;   British Heart Foundation;   St. Jude Medical;   University of Glasgow
Active, not recruiting - verified July 2016

Perfusion CT Registry

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   Young-Hak Kim, MD, PhD
Recruiting - verified July 2016

A Pivotal Trial to Establish the Efficacy and Long-term Safety of the Parachute Implant System

Conditions:   Congestive Heart Failure;   Left Ventricular (LV) Systolic Dysfunction
Intervention:   Device: CardioKinetix Parachute Implant and All Appropriate Medical Therapy (AAMT)
Sponsor:   CardioKinetix, Inc
Recruiting - verified July 2016

The Supplementary Role of Non-invasive Imaging to Routine Clinical Practice in Suspected Non-ST-elevation Myocardial Infarction

Conditions:   Chest Pain;   Myocardial Infarction;   Acute Coronary Syndrome;   Coronary Artery Disease;   Myocardial Ischemia
Interventions:   Other: Cardiovascular Magnetic Resonance Imaging;   Other: Computed Tomography Angiography
Sponsors:   Maastricht University Medical Center;   Dutch Heart Foundation
Active, not recruiting - verified July 2016

Vitamin K to Attenuate Coronary Artery Calcification in Hemodialysis Patients

Condition:   Endstage Kidney Disease
Interventions:   Drug: Vitamin K1;   Drug: Chrystalline Lactose
Sponsors:   Dr. Rachel Holden;   Kingston General Hospital
Recruiting - verified July 2016

Reducing Radioisotope Dose: the Half-Dose CZT Study

Condition:   Coronary Artery Disease
Intervention:   Other: Half-dose isotope for NuclearStressTest
Sponsor:   The Methodist Hospital System
Recruiting - verified July 2016

A Open-Label Study Of CP-690,550 As Long-Term Therapy (48 Weeks) In Subjects With Crohn's Disease

Condition:   Crohn's Disease
Interventions:   Drug: CP-690,550;   Drug: CP-690,550
Sponsor:   Pfizer
Recruiting - verified July 2016

Vest Prevention of Early Sudden Death Trial and VEST Registry

Conditions:   Myocardial Infarction;   Ventricular Dysfunction;   Sudden Death;   Ventricular Tachycardia;   Ventricular Fibrillation
Intervention:   Device: wearable defibrillator
Sponsors:   University of California, San Francisco;   Zoll Medical Corporation
Recruiting - verified July 2016

Identification of Genomic Predictors of Adverse Events After Cardiac Surgery

Conditions:   Heart; Dysfunction Postoperative, Cardiac Surgery;   Genetic Predisposition to Disease;   Atrial Fibrillation;   Myocardial Infarction;   Heart Failure
Intervention:  
Sponsors:   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI);   Texas Heart Institute;   University of Texas Southwestern Medical Center
Recruiting - verified July 2016

EXCEL Clinical Trial

Conditions:   Chronic Coronary Occlusion;   Unprotected Left Main Coronary Artery Disease;   Stent Thrombosis;   Vascular Disease;   Myocardial Ischemia;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Artery Disease;   Coronary Restenosis
Interventions:   Device: Percutaneous Coronary Intervention;   Procedure: CABG
Sponsor:   Abbott Vascular
Active, not recruiting - verified July 2016

Effects of Amino Acids on Regional Lipid Metabolism

Condition:   Hypertriglyceridemia
Interventions:   Dietary Supplement: Amino acids;   Dietary Supplement: Placebo
Sponsors:   University of Arkansas;   National Institute on Aging (NIA)
Recruiting - verified July 2016

IMAGE-HF Project I-A: Cardiac Imaging in Ischemic Heart Failure (AIMI-HF)

Conditions:   Heart Failure;   Coronary Artery Disease;   Ischemic Cardiomyopathy;   Non-ischemic Cardiomyopathy
Interventions:   Other: Advanced cardiac imaging;   Other: Standard Cardiac Imaging
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research (CIHR);   The Finnish Funding Agency for Technology and Innovation (TEKES)
Recruiting - verified July 2016

Rubidium-82 - An Alternative Radiopharmaceutical for Myocardial Imaging(Rb-ARMI)

Condition:   Coronary Artery Disease
Intervention:   Other: Myocardial perfusion imaging using Rb-82 PET or Tc-99m or Tl SPECT
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting - verified July 2016

Clinical Trial for Dose Finding and Safety of RVX000222 in Subjects With Stable Coronary Artery Disease

Conditions:   Atherosclerosis;   Coronary Artery Disease
Interventions:   Drug: RVX000222;   Drug: Placebo
Sponsor:   Resverlogix Corp
Completed - verified July 2016

A Study With Aleglitazar in Patients With a Recent Acute Coronary Syndrome and Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus Type 2
Interventions:   Drug: Aleglitazar;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Completed - verified July 2016

IK-1001 (Sodium Sulfide (Na2S) for Injection) in Subjects With Acute ST-Segment Elevation Myocardial Infarction

Condition:   ST-Segment Elevation Myocardial Infraction
Interventions:   Drug: Sodium Sulfide (Na2S) for Injection;   Drug: Placebo
Sponsor:   Mallinckrodt
Withdrawn - verified July 2016

Associations Between Diabetes Care and Haptoglobin Genotype On outComes

Conditions:   Diabetes;   Cardiovascular Disease;   Myocardial Infarction;   Stroke
Intervention:  
Sponsor:   Clalit Health Services
Active, not recruiting - verified July 2016

Cardiac FDG PET Viability Registry

Conditions:   Heart Failure;   Ischemic Heart Disease;   Myocardial Dysfunction
Intervention:  
Sponsors:   Ottawa Heart Institute Research Corporation;   Ontario Ministry of Health and Long Term Care
Recruiting - verified July 2016

Safety, Pharmacokinetic Study of RVX000222 in Healthy Subjects and Subjects With Low HDL Cholesterol

Conditions:   Dyslipidemia;   Atherosclerosis;   Acute Coronary Syndrome;   Cardiovascular Disease
Interventions:   Drug: RVX000222;   Drug: Placebo
Sponsor:   Resverlogix Corp
Completed - verified July 2016

The Melatonin Adjunct in the Acute myocaRdial Infarction Treated With Angioplasty

Condition:   Acute Myocardial Infarction
Intervention:   Drug: melatonin
Sponsor:   Alberto Domínguez Rodríguez
Terminated - verified July 2016

Relative Risks for Non-fatal Venous Thromboembolism, Ischemic Stroke and Myocardial Infarction in Users of ORTHO EVRA(Norelgestromin and Ethinyl Estradiol Contraceptive Patch) Compared to Levonorgestrel-containing Oral Contraceptives.

Conditions:   Contraception;   Female Contraception;   Fertility Control
Intervention:  
Sponsors:   Johnson & Johnson Pharmaceutical Research & Development, L.L.C.;   Boston Collaborative Drug Surveillance Program
Completed - verified July 2016

PET and Recovery Following Revascularization (PARR 2)

Conditions:   Coronary Artery Disease;   Ventricular Dysfunction, Left
Interventions:   Procedure: Positron emission tomography: FDG viability imaging;   Other: PET imaging
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research (CIHR);   Heart and Stroke Foundation of Ontario
Completed - verified July 2016

Cardiology Biobank Registry

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   Emory University
Recruiting - verified July 2016

A Postmarketing Study of the Risk of Venous Thromboembolism (Blood Clots), Myocardial Infarction (Heart Attacks), and Stroke Among Women Using ORTHO EVRA (Norelgestromin and Ethinyl Estradiol Contraceptive Patch) Compared With Women Who Take Oral Contraceptives for Birth Control

Conditions:   Contraception;   Female Contraception
Interventions:   Drug: Transdermal Contraceptive System;   Drug: Norgestimate-containing oral contraceptives with EE
Sponsor:   Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Completed - verified July 2016

Genetic Factors in Atherosclerosis

Condition:   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Completed - verified March 2013

Non-invasive Diagnosis of Coronary Artery Stenoses by Doppler Echocardiography

Conditions:   Stable Angina Pectoris;   Unstable Angina Pectoris;   Acute Myocardial Infarction
Intervention:   Procedure: Doppler echocardiography
Sponsor:   Norwegian University of Science and Technology
Completed - verified July 2016

Effect of Increased Oxygenation in the Air During Endurance Training in Stable Angina Pectoris Patients

Condition:   Angina Pectoris
Interventions:   Behavioral: Hypoxic interval training;   Behavioral: Normoxic interval training
Sponsors:   Norwegian University of Science and Technology;   Aarhus University Hospital
Completed - verified July 2016

Estrogen Replacement to Reduce Risk of Neurologic Injury After Coronary Artery Bypass Graft Surgery

Conditions:   Coronary Disease;   Cardiovascular Diseases;   Heart Diseases;   Neurologic Manifestations
Interventions:   Drug: Estrogen Replacement Therapy;   Procedure: Surgery
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Terminated - verified December 2007

Logical Analysis of Data and Cardiac Surgery Risk

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Coronary Disease;   Aortic Valve Stenosis;   Mitral Valve Stenosis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

MRI Derived Organ & Tissue Mass Changes With Weight Loss - Ancillary to Look AHEAD

Conditions:   Cardiovascular Diseases;   Atherosclerosis;   Obesity;   Diabetes Mellitus, Non-insulin Dependent;   Heart Diseases;   Myocardial Infarction;   Diabetes Mellitus
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

Heavy Metals, Obesity and Cardiovascular Risk - Ancillary to Look AHEAD

Conditions:   Diabetes Mellitus, Non-insulin Dependent;   Cardiovascular Diseases;   Obesity;   Myocardial Infarction;   Heart Diseases;   Diabetes Mellitus
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Heart Failure, Congestive;   Heart Diseases
Interventions:   Procedure: CABG surgery plus MED;   Drug: Active Medication Alone;   Procedure: CABG plus MED and SVR
Sponsors:   Duke University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified July 2016

Genetics of Coronary Artery Disease in Alaskan Natives (GOCADAN)

Conditions:   Heart Diseases;   Cardiovascular Diseases;   Atherosclerosis;   Hypertension;   Diabetes Mellitus;   Coronary Arteriosclerosis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified May 2009

Multi-Ethnic Study of Atherosclerosis (MESA)

Conditions:   Atherosclerosis;   Cardiovascular Diseases;   Heart Diseases;   Coronary Artery Disease;   Coronary Disease;   Stroke;   Myocardial Infarction;   Heart Failure;   Diabetes Mellitus, Type 2;   Hypertension;   Diabetes Mellitus
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified April 2012

Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Diabetes Mellitus;   Heart Diseases;   Hypercholesterolemia;   Hypertension;   Myocardial Infarction;   Myocardial Ischemia;   Heart Failure
Interventions:   Drug: Inhibitors, ACE;   Drug: amlodipine;   Drug: lisinopril;   Drug: doxazosin;   Drug: chlorthalidone;   Drug: pravastatin;   Behavioral: diet, fat-restricted
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified February 2009