Coronary Artery Disease

Clinical Trial Finder

Many patients with coronary artery disease are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Hybrid Coronary Revascularization Trial

Condition:   Coronary Artery Disease
Interventions:   Procedure: Left Internal Mammary Artery (LIMA) to LAD;   Procedure: PCI with metallic DES of non-LAD vessel(s);   Procedure: Percutaneous Coronary Intervention
Sponsors:   Icahn School of Medicine at Mount Sinai;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified March 2017

Low Intensity Resistance Training With Vascular Occlusion in Coronary Heart Disease Patients

Conditions:   Coronary Disease;   Coronary Artery Disease
Intervention:   Other: Resistance training with vascular occlusion
Sponsors:   University Medical Centre Ljubljana;   University of Ljubljana, Faculty of Sport
Recruiting - verified March 2017

Cardiac and Endothelial Function Response to Early Exercise Training After Coronary Artery Bypass Surgery

Conditions:   Coronary Artery Bypass Grafting;   Coronary Artery Disease;   Cardiac Rehabilitation
Interventions:   Other: Functional Electrical Stimulation (FES);   Other: Ventilatory Muscle Training (TREMVEN);   Other: Aerobic Training (AERO);   Other: Isometric Handgrip Training (ISO)
Sponsor:   Instituto de Cardiologia do Rio Grande do Sul
Not yet recruiting - verified March 2017

Effects of Respiratory Muscle Training on Postoperative Pulmonary Complications of Cardiac Surgery

Conditions:   Heart Diseases;   Coronary Disease;   Cardiovascular Diseases;   Coronary Artery Occlusion
Intervention:   Other: Inspiratory Muscle Training
Sponsor:   University of the State of Santa Catarina
Completed - verified March 2017

Impact of Evolocumab on the Effects of Clopidogrel in Patients With High On-Treatment Platelet Reactivity

Condition:   Atherosclerotic Cardiovascular Disease
Interventions:   Drug: Evolocumab;   Other: Placebo
Sponsors:   University of Florida;   Amgen
Not yet recruiting - verified March 2017

To Evaluate Safety and Efficacy of CGBIO Stent Compared to Biomatrix Flex Stent

Conditions:   Ischemic Heart Disease;   Stable Coronary Artery Disease;   Stable Angina;   Unstable Angina;   NSTEMI - Non-ST Segment Elevation MI
Interventions:   Device: CGBio stent;   Device: Biomatrix flex
Sponsor:   CGBio Inc.
Recruiting - verified March 2017

The Efficacy and Safety of the Xu-Fu-Zhu-Yu Capsule in Treatment of Qi Stagnation and Blood Stasis Syndrome.

Condition:   Qi Stagnation and Blood Stasis Syndrome
Interventions:   Drug: xue-fu-zhu-yu capsule;   Drug: xue-fu-zhu-yu capsule simulated agent
Sponsor:   Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Not yet recruiting - verified March 2017

Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS

Conditions:   Aortic Valve Stenosis;   Hypertrophy, Left Ventricular
Intervention:   Procedure: Aortic valve intervention
Sponsors:   University of Edinburgh;   Sir Jules Thorn Charitable Trust
Not yet recruiting - verified February 2017

Effects of Dexmedetomidine on Patients With Coronary Heart Disease After Percutaneous Coronary Intervention

Condition:   Heart Injuries
Interventions:   Drug: Dexmedetomidine;   Drug: 0.9%NaCl solution
Sponsor:   First Affiliated Hospital Xi'an Jiaotong University
Not yet recruiting - verified February 2017

Low-dose of Ticagrelor and Double Standard-dose Clopidogrel on Platelet Aggregation in Clopidogrel Resistance's Patients With Coronary Heart Disease

Conditions:   Coronary Artery Disease;   Clopidogrel, Poor Metabolism of
Interventions:   Drug: Clopidogrel;   Drug: ticagrelor
Sponsor:   First Affiliated Hospital of Harbin Medical University
Recruiting - verified February 2017

Beijing Hospital Atherosclerosis Study

Conditions:   Atherosclerosis;   Cardiovascular Diseases;   Coronary Artery Disease;   Myocardial Ischemia;   Stroke
Intervention:  
Sponsor:   Beijing Hospital
Recruiting - verified March 2017

Effect of Antithrombotic Treatment in Patients With Both Coronary Heart Disease and Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Coronary Heart Disease
Intervention:  
Sponsor:   Henan Institute of Cardiovascular Epidemiology
Recruiting - verified March 2017

Impact of EMpagliflozin on Cardiac Function and Biomarkers of Heart Failure in Patients With Acute MYocardial Infarction

Condition:   Acute Myocardial Infarction
Interventions:   Drug: Empagliflozin 10 mg;   Drug: Placebo Oral Tablet
Sponsors:   Medical University of Graz;   United Arab Emirates University;   Medical University of Vienna;   Landeskrankenhaus Feldkirch;   Krankenhaus der Barmherzigen Brüder Linz;   Kepler University Hospital;   Paracelsus Medical University
Not yet recruiting - verified March 2017

Sonothrombolysis in Patients With STEMI

Condition:   ST-segment Elevation Myocardial Infarction
Interventions:   Drug: Definity, (Lipid Microspheres) Intravenous Suspension;   Device: Myocardial Contrast Echocardiography;   Procedure: Repurfusion therapy with PPCI
Sponsors:   Harald Becher;   Alberta Health Services;   University of Alberta
Not yet recruiting - verified March 2017

Connecting Periodontal and Coronary Artery Disease Via the Inflammatory State of the Body

Conditions:   Periodontal Diseases;   Cardiovascular Diseases
Intervention:   Other: periodontal probing
Sponsor:   Texas Tech University Health Sciences Center
Not yet recruiting - verified March 2017

Long Term Follow Up for CTSN Mitral Valve Repair Studies

Conditions:   Mitral Valve Insufficiency;   Coronary Artery Disease
Interventions:   Other: MV Repair;   Other: MV Replacement;   Other: CABG
Sponsors:   Icahn School of Medicine at Mount Sinai;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research (CIHR)
Not yet recruiting - verified March 2017

Effect of Amlodipine Versus Amlodipine Combined With Atorvastatin on the Coronary Vasospastic Angina

Condition:   Quality of Life
Interventions:   Drug: Caduet 10Mg-20Mg Tablet;   Drug: NorvasC® 10 mg Tablets
Sponsor:   Kosin University Gospel Hospital
Not yet recruiting - verified March 2017

A Behavioral Economics-Based Telehealth Intervention to Improve Post-MI Medication Adherence

Conditions:   Myocardial Infarction, Acute;   Myocardial Infarction
Intervention:   Behavioral: Financial Incentive and Mobile Phone App
Sponsors:   Wellth Inc.;   University of Pennsylvania
Recruiting - verified March 2017

Metabolomic Profile of Patients Undergoing Myocardial Perfusion SPECT

Condition:   Ischemic Heart Disease
Intervention:   Other: Non intervention
Sponsor:   Hospital Universitari Vall d'Hebron Research Institute
Recruiting - verified March 2017

A Double-blind Study to Investigate Efficacy, Safety and Tolerability of BAY 1142524 in Patients After Acute Myocardial Infarction With Left-ventricular Dysfunction

Condition:   Myocardial Infarction
Interventions:   Drug: BAY1142524;   Drug: Placebo
Sponsor:   Bayer
Recruiting - verified March 2017

Ad5FGF-4 In Patients With Refractory Angina Due to Myocardial Ischemia

Condition:   Angina, Stable
Interventions:   Biological: Ad5FGF-4;   Biological: Placebo
Sponsors:   Angionetics Inc.;   Huapont Life Sciences
Not yet recruiting - verified March 2017

Real Time Myocardial Perfusion Echocardiography for Coronary Allograft Vasculopathy

Condition:   Cardiac Allograft Vasculopathy
Interventions:   Drug: Perflutren Lipid Microsphere;   Procedure: RTMPE
Sponsors:   Mayo Clinic;   University of Calgary
Recruiting - verified March 2017

Exploratory P2 Trial to Evaluate Efficacy and Safety of Clotinab® (Abciximab) in Acute MI Patients

Condition:   Acute Myocardial Infarction
Interventions:   Biological: Abciximab;   Biological: Placebo
Sponsor:   ISU Abxis Co., Ltd.
Active, not recruiting - verified July 2016

Thin Strut Sirolimus-eluting Stent in All Comers Population vs Everolimus-eluting Stent

Condition:   Coronary Stenosis
Interventions:   Device: SUPRAFLEX;   Device: XIENCE
Sponsors:   ECRI bv;   Sahajanand Medical Technologies Pvt. Ltd.
Recruiting - verified March 2017

Quantitative Cardiac Parametric Mapping (Myomapping)

Condition:   Cardiomyopathy, Myocarditis, Ischemic Heart Disease
Intervention:   Other: Cardiac Magnetic Resonance (CMR) imaging techniques
Sponsor:   Medical University of South Carolina
Recruiting - verified March 2017

A Study of Structure and Function of Radial Artery After Transradial Coronary Intervention

Conditions:   Intervention;   Transradial
Intervention:   Procedure: Percutaneous coronary intervention
Sponsor:   The First Hospital of Qinhuangdao
Recruiting - verified July 2016

Study to Evaluate the Effect of Nicotinamide Riboside on Immunity

Conditions:   Atherosclerosis;   Diabetes;   Coronary Artery Disease
Interventions:   Dietary Supplement: Nicotinamide riboside (NR);   Other: Placebo
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 15, 2017

Studying Partial-agonists for Ethanol and Tobacco Elimination in Russians With HIV (St PETER HIV)

Conditions:   HIV Infection;   Alcohol Use;   Smoking
Interventions:   Drug: Varenicline;   Drug: Cytisine;   Drug: Nicotine Replacement Therapy;   Drug: Varenicline Placebo;   Drug: Cytisine Placebo;   Drug: Nicotine Replacement Therapy Placebo
Sponsors:   Boston Medical Center;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Not yet recruiting - verified March 2017

WilL LOWer Dose Aspirin be More Effective Following ACS? (WILLOW - ACS)

Condition:   Acute Coronary Syndrome
Intervention:   Drug: Aspirin
Sponsor:   Sheffield Teaching Hospitals NHS Foundation Trust
Active, not recruiting - verified March 2017

ShenFu Injection for Myocardial Protection in Patients With Acute ST Segment Elevation Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Drug: Shenfu Injection;   Drug: 5% Glucose Injection
Sponsors:   Beijing Anzhen Hospital;   China Resources Sanjiu Medical & Pharmaceutical Co., Ltd.
Recruiting - verified March 2017

Drug Eluting Balloon for Treatment of Unstable Angina

Condition:   Angina, Unstable
Interventions:   Device: drug eluting balloon; cutting balloon;   Device: drug eluting stent
Sponsor:   Yun Dai Chen
Recruiting - verified September 2016

Synchronized Cardiac Assist for Cardiogenic Shock

Conditions:   Shock, Cardiogenic;   High Risk Percutaneous Coronary Interventions
Intervention:   Drug: i-cor Synchronized Cardiac Assist Device
Sponsors:   Xenios AG;   MAXIS Medical
Recruiting - verified March 2017

Feasibility and Outcomes of Complete Coronary Revascularization Using BVS in All-comer Patients With Angina

Condition:   Angina
Intervention:   Device: Bioresorbable vascular scaffold (BVS) implantation
Sponsors:   International Foundation for Development of Medical Science and Education Healthy Heart;   KCRI
Recruiting - verified September 2016

Sirolimus-eluting Stent CALYPSO vs Everolimus-eluting Stent XIENCE

Conditions:   Ischemic Heart Disease;   Coronary Atherosclerosis;   Coronary Artery Disease;   Coronary Artery Stenosis
Interventions:   Device: DES "Calypso";   Device: DES "Xience Prime";   Procedure: Coronary angioplasty
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Recruiting - verified March 2017

Stem Cell Therapy in IschEmic Non-treatable Cardiac Disease

Condition:   Heart Failure
Intervention:   Biological: CSCC_ASC
Sponsors:   JKastrup;   European Union
Recruiting - verified March 2017

Increasing Exercise and Decreasing Sedentary Behavior Among Patients in a Cardiac Rehabilitation Clinic

Conditions:   Acute Coronary Syndrome;   Heart Failure;   Other Cardiac Conditions Among Cardiac Rehabilitation Participants
Interventions:   Other: B-MOBILE-CARDIAC smartphone application;   Behavioral: Cardiac rehabilitation as usual
Sponsor:   The Miriam Hospital
Enrolling by invitation - verified March 2017

EVOLVE Short DAPT Study

Condition:   Coronary Artery Disease
Interventions:   Drug: 3 months of dual antiplatelet therapy (DAPT);   Device: SYNERGY Stent System
Sponsor:   Boston Scientific Corporation
Recruiting - verified March 2017

"Me and My Heart" Study

Condition:   Acute Coronary Syndrome
Interventions:   Device: Active group with MEMS;   Device: Active group without MEMS;   Device: Control group with MEMS;   Device: Control group without MEMS
Sponsor:   AstraZeneca
Recruiting - verified March 2017

SNPs in the DNase 1 Gene Impair Its Activity and Are Increased in a STE-ACS Patient Cohort Compared to Healthy Controls

Condition:   ST Elevation Myocardial Infarction
Intervention:   Other: Blood draw
Sponsor:   Medical University of Vienna
Enrolling by invitation - verified March 2017

WISE CVD - Continuation (WISE HFpEF)

Conditions:   Microvascular Coronary Dysfunction;   Cardiovascular Disease
Interventions:   Procedure: Coronary Angiography;   Procedure: Coronary Reactivity Testing;   Procedure: Cardiac Magnetic Resonance Imaging;   Procedure: Cardiac Magnetic Resonance Angiography;   Procedure: Computed Coronary Tomographic Angiography;   Procedure: Rest-Stress Millar Testing;   Procedure: Aortic vasorelaxation tests
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified March 2017

Implantable Cardiac Monitors in High-Risk Post-Infarction Patients With Cardiac Autonomic Dysfunction

Conditions:   Myocardial Infarction;   Autonomic Nervous System Diseases
Intervention:   Device: Medtronic Reveal LINQ implantable cardiac monitor
Sponsors:   Klinikum der Universitaet Muenchen;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK);   Medtronic Bakken Research Center
Recruiting - verified March 2017

Vulnerable Plaque Imaging in NSTEMI

Conditions:   Myocardial Infarction;   Myocardial Ischemia
Intervention:  
Sponsor:   Maastricht University Medical Center
Not yet recruiting - verified March 2017

Atorvastatin Effectiveness and Safety in Cardiology Patients in Real World Setting

Condition:   Coronary Artery Disease, Hypercholesterolemia, Hypertension
Intervention:   Other: No intervention
Sponsor:   Pfizer
Recruiting - verified March 2017

Study of Multistep Pharmacological and Invasive Management for Cardiogenic Shock

Condition:   Cardiogenic Shock
Intervention:   Drug: adrenaline
Sponsors:   Niguarda Hospital;   Papa Giovanni XXIII Hospital
Recruiting - verified March 2017

Vorapaxar as an Add-On Antiplatelet Therapy in Patients With and Without Diabetes Mellitus

Conditions:   Myocardial Infarction;   Diabetes Mellitus;   Peripheral Arterial Disease
Interventions:   Drug: Vorapaxar;   Drug: Clopidogrel;   Drug: Aspirin
Sponsors:   University of Florida;   Merck Sharp & Dohme Corp.
Recruiting - verified March 2017

Evaluating Increasing Physical Activity After Acute Coronary Syndrome

Conditions:   Physical Activity;   Acute Coronary Syndrome
Interventions:   Behavioral: Financial incentive;   Behavioral: Daily feedback
Sponsor:   University of Pennsylvania
Active, not recruiting - verified March 2017

Allogeneic Stem Cell Therapy in Heart Failure

Condition:   Heart Failure
Interventions:   Biological: Cardiology Stem Cell Centre Adipose Stem Cell (CSCC_ASC);   Biological: Placebo
Sponsor:   JKastrup
Recruiting - verified March 2017

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Recruiting - verified March 2017

Absorb BVS vs. Drug Coated Balloon for Treatment Of ISR

Conditions:   Coronary Artery Disease;   Coronary Restenosis
Interventions:   Device: BVS Absorb implantation.;   Device: DEB Sequent Please inflation.;   Procedure: Control coronary angiography.;   Procedure: OCT visualization.;   Other: Clinical observation.
Sponsor:   SIS Medical AG
Recruiting - verified March 2017

Prospective Registry of Acute Heart Failure

Condition:   Acute Heart Failure
Intervention:   Procedure: blood sample
Sponsor:   Sebastian Carballo
Recruiting - verified March 2017

A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart

Condition:   Acute Coronary Syndromes
Interventions:   Drug: Apixaban;   Drug: vitamin K antagonist;   Drug: Acetylsalicylic acid;   Other: Acetylsalicylic acid placebo
Sponsors:   Bristol-Myers Squibb;   Pfizer;   Duke Clinical Research Institute
Recruiting - verified March 2017

Biomarkers and Cardiac CT

Conditions:   Coronary Artery Disease;   Atherosclerosis
Intervention:   Biological: Venous blood sampling prior to CCTA.
Sponsor:   Maastricht University Medical Center
Recruiting - verified March 2017

Sequential Coronary CT-angiography and Biomarkers

Conditions:   Coronary Artery Disease;   Atherosclerosis
Interventions:   Radiation: Coronary CT-angiography;   Other: Assesment of biomarkers involved in atherothrombosis
Sponsor:   Maastricht University Medical Center
Recruiting - verified March 2017

COMBinAtion Therapy in Myocardial Infarction: The COMBAT-MI Trial

Condition:   ST Elevation Acute Myocardial Infarction
Interventions:   Drug: Exenatide;   Other: Remote Ischemic Conditioning (RIC);   Drug: Placebo
Sponsor:   Hospital Universitari Vall d'Hebron Research Institute
Recruiting - verified March 2017

Optimal Lesion Preparation With Non-compliant Balloons Before Implantation Of Bioresorbable Scaffolds (OPreNBiS)

Conditions:   Coronary Artery Disease;   Angina;   Unstable Angina;   Stable Angina
Interventions:   Device: Predilatation with OPN NC balloon catheter.;   Device: Predilatation with standard compliant balloon.;   Device: Absorb BVS implantation.;   Procedure: Treated segment visualization by OCT.;   Other: Clinical FU at 12 months.
Sponsor:   SIS Medical AG
Recruiting - verified September 2016

Ciclosporin to Reduce Reperfusion Injury in Primary PCI

Condition:   Myocardial Reperfusion Injury
Interventions:   Drug: Ciclosporin;   Drug: Saline
Sponsors:   Newcastle-upon-Tyne Hospitals NHS Trust;   National Institute for Health Research, United Kingdom;   Newcastle University
Active, not recruiting - verified March 2017

Physicians International CT Utilization Registry 2

Condition:   Coronary Artery Disease
Intervention:   Procedure: CCTA
Sponsor:   MDDX LLC
Withdrawn - verified September 2015

Effects of Linagliptin on Endothelial Function

Conditions:   Type 2 Diabetes;   Coronary Artery Disease
Interventions:   Drug: Linagliptin;   Drug: Placebo
Sponsor:   Medical University of Graz
Completed - verified March 2017

Coronary Steal Via Natural Internal Mammary Artery-To-Coronary Artery Bypasses

Conditions:   Coronary Artery Disease;   Ischemia
Intervention:   Other: Coronary Artery Balloon Occlusion for Determination of Collateral Flow Index
Sponsor:   University Hospital Inselspital, Berne
Suspended - verified March 2017

Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease

Condition:   Microvascular Coronary Dysfunction
Interventions:   Other: Handgrip;   Other: Altitude simulation;   Other: Leg exercise
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified March 2017

Effect of Combination of Non-sLip Element Balloon (NSE) and druG-coated bAlloon (DCB) for In-steNT Restenosis Lesions

Condition:   Coronary Restenosis
Interventions:   Device: Non-slip element balloon (NSE);   Device: Balloon
Sponsors:   Mitsui Memorial Hospital;   Teikyo University;   Tokai University
Active, not recruiting - verified March 2017

A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Acetylsalicylic acid;   Drug: Rivaroxaban;   Drug: Clopidogrel;   Drug: Ticagrelor
Sponsors:   Janssen Research & Development, LLC;   Bayer;   Duke Clinical Research Institute;   Harvard Medical School
Completed - verified March 2017

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified March 2017

Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

Conditions:   Stroke;   Secondary Prevention
Interventions:   Drug: optional ASA as comedication;   Drug: placebo to ASA;   Drug: placebo to optional ASA as comedication;   Drug: placebo to dabigatran etexilate;   Drug: ASA 100 mg;   Drug: dabigatran etexilate
Sponsor:   Boehringer Ingelheim
Recruiting - verified March 2017

"Preventing Cardiovascular Ischemic Events and Arresting Their Consequences in Type 2 Diabetic Population

Conditions:   Type2 Diabetes Mellitus;   Microangiopathy;   Non Alcoholic Fatty Liver Disease;   Coronary Artery Disease;   Cerebrovascular Disease;   Acute Coronary Syndrome/ Myocardial Infarction;   Ictus
Intervention:  
Sponsor:   Hospital Universitari Vall d'Hebron Research Institute
Recruiting - verified March 2017

Coronary CT Angiography Using a Novel 3rd Generation Dual-Source CT System

Condition:   Coronary Artery Disease
Interventions:   Procedure: Coronary CT angiography on SOMATOM Force;   Procedure: Previous coronary CT angiography on 2nd generation CT scanner
Sponsor:   U. Joseph Schoepf, MD
Suspended - verified March 2017

Focus On Stiffness Reduction, Endothelial Function and Autonomic Nervous System

Conditions:   Arterial Stiffness;   Endothelial Function;   Autonomic Nervous System;   Acute Coronary Syndrome;   Arterial Hypertension
Intervention:   Other: comprehensive cardiac rehabilitation
Sponsor:   Medical Universtity of Lodz
Completed - verified March 2017

The Gentle Cardiac Rehabilitation Study

Condition:   Secondary Prevention of Coronary Heart Disease
Interventions:   Behavioral: PLUS;   Behavioral: LITE
Sponsors:   The Miriam Hospital;   National Institutes of Health (NIH);   National Center for Complementary and Integrative Health (NCCIH)
Completed - verified March 2016

A Phase 3 Clinical Outcomes Study to Compare the Incidence of Major Adverse Cardiovascular Events in Subjects Presenting With Acute Coronary Syndrome Treated With Losmapimod Compared to Placebo (LATITUDE-TIMI 60)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Losmapimod 7.5 mg twice daily;   Drug: Placebo twice daily;   Drug: Standard therapy
Sponsors:   GlaxoSmithKline;   The TIMI Study Group
Completed - verified March 2017

Carnitine for the Treatment of Atherosclerosis.

Condition:   Metabolic Syndrome
Interventions:   Dietary Supplement: L-carnitine capsules;   Dietary Supplement: Cellulose capsules
Sponsors:   Queen's University;   Heart and Stroke Foundation of Canada
Active, not recruiting - verified March 2017

Early Predictive Factors of Cardiac and Cerebral Involvement in TMA

Conditions:   Thrombotic Microangiopathies;   Thrombotic Thrombocytopenic Purpura
Intervention:   Other: Biological and imaging investigations
Sponsor:   Assistance Publique - Hôpitaux de Paris
Active, not recruiting - verified March 2017

Essential Hypotension and Allostasis Registry

Conditions:   Blood Pressure;   Depression;   Panic Attack;   Fibromyalgia;   POTS;   Inappropriate Sinus Tachycardia;   Coronary Heart Disease;   Acute Coronary Syndrome (ACS);   Acute Myocardial Infarction (AMI);   Cerebrovascular Disease (CVD);   Transient Ischemic Attack (TIA);   Atrial Fibrillation;   Diabetes Mellitus;   Cancer;   Systolic Heart Failure;   Diastolic Heart Failure;   Chronic Fatigue Syndrome;   Syncope;   Vasovagal Syncope
Intervention:  
Sponsor:   CES University
Recruiting - verified March 2017

Study to Assess the Safety and Cardiovascular Effects of Autologous Adipose-Derived Stromal Cells Implantation In Patients During the Acute Recovery Phase of ST-Elevation Myocardial Infarction

Condition:   Acute Myocardial Infarction
Intervention:   Procedure: ASC isolation and implantation
Sponsors:   Ageless Regenerative Institute;   Instituto de Medicina Regenerativa, S.A. de C.V.
Withdrawn - verified March 2017

Study of Tenecteplase Versus Alteplase for Thrombolysis (Clot Dissolving) in Acute Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: Tenecteplase;   Drug: Alteplase
Sponsors:   Lars Thomassen;   The Research Council of Norway
Completed - verified March 2017

Benefit of Elevation of HDL-C in Women

Condition:   Cardiovascular Outcomes
Interventions:   Drug: Niaspan;   Drug: Placebo
Sponsor:   Cedars-Sinai Medical Center
Completed - verified March 2017

Cardiac Magnetic Resonance Imaging Strategy for the Management of Patients With Acute Chest Pain and Detectable to Elevated Troponin

Conditions:   Acute Coronary Syndrome;   Chest Pain
Interventions:   Procedure: Cardiac MRI;   Other: ACC/AHA Guideline adherent care
Sponsors:   Wake Forest University Health Sciences;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2017

Non-isotope Based Imaging Modalities vs Technetium-99m Single-Photon Emission Computed Tomography(99mTcSPECT)

Condition:   Myocardial Ischemia
Intervention:  
Sponsors:   Montreal Heart Institute;   Canadian Institutes of Health Research (CIHR)
Recruiting - verified March 2017

Coronary Computed Tomographic Angiography for Selective Cardiac Catheterization

Condition:   Coronary Artery Disease
Interventions:   Procedure: Cardiac CT;   Procedure: Invasive Coronary Angiography
Sponsors:   MDDX LLC;   GE Healthcare
Completed - verified March 2017

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention &Amp; Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute;   Janssen Research & Development, LLC
Recruiting - verified March 2017

Cooling in Myocardial Infarction

Condition:   ST-elevation Myocardial Infarction
Intervention:   Device: EMCOOLS flex pad; Philips Innercool RTx
Sponsors:   Medical University of Vienna;   Austrian Science Fund (FWF)
Active, not recruiting - verified March 2017

Efficacy Evaluation of the HEART Pathway in Emergency Department Patients With Acute Chest Pain

Conditions:   Acute Coronary Syndrome;   Chest Pain
Intervention:   Other: HEART Pathway
Sponsors:   Wake Forest University Health Sciences;   American Heart Association
Active, not recruiting - verified February 2017

Daily REmote Ischaemic Conditioning Following Acute Myocardial Infarction

Condition:   Post Myocardial Infarction
Interventions:   Procedure: Remote Ischaemic Conditioning administered via the inflation of a blood pressure cuff on the upper arm;   Procedure: Sham conditioning
Sponsors:   University of Leicester;   University Hospitals, Leicester;   Freemasons' Medical Research Funding
Completed - verified August 2012

A Pivotal Trial to Establish the Efficacy and Long-term Safety of the Parachute Implant System

Conditions:   Congestive Heart Failure;   Left Ventricular (LV) Systolic Dysfunction
Intervention:   Device: CardioKinetix Parachute Implant and All Appropriate Medical Therapy (AAMT)
Sponsor:   CardioKinetix, Inc
Recruiting - verified March 2017

Coronary Hybrid Revascularisation Study

Condition:   Significant Coronary Artery Disease
Intervention:   Procedure: Combined CABG and PCI
Sponsor:   Aarhus University Hospital Skejby
Active, not recruiting - verified March 2017

Hybrid Sirolimus-eluting Versus Everolimus-eluting Stents for Total Coronary Occlusions

Conditions:   Coronary Artery Disease;   Coronary Disease;   Coronary Stenosis
Intervention:   Device: Hybrid sirolimus- and everolimus-eluting stents (ORSIRO, XIENCE PRIME)
Sponsors:   R&D Cardiologie;   Biotronik SE & Co. KG
Active, not recruiting - verified March 2017

Evaluation of the Safety and Efficacy of Using Insulin-like Growth Factor-1 in Patients With a Heart Attack

Conditions:   Heart Failure;   Myocardial Infarction
Interventions:   Drug: mecasermin;   Drug: mecasermin;   Drug: 0.9% sodium chloride injection
Sponsor:   University College Cork
Completed - verified March 2017

The "Virtual" Multicenter Spontaneous Coronary Artery Dissection (SCAD) Registry

Conditions:   Spontaneous Coronary Artery Dissection;   SCAD
Intervention:  
Sponsor:   Mayo Clinic
Recruiting - verified March 2017

Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care

Conditions:   Adenovirus;   Adrenal Insufficiency;   Airway Swelling;   Anesthesia;   Anxiety;   Anxiolysis;   Autism;   Autistic Disorder;   Bacterial Meningitis;   Bacterial Septicemia;   Benzodiazepine;   Bipolar Disorder;   Bone and Joint Infections;   Brain Swelling;   Central Nervous System Infections;   Convulsions;   Cytomegalovirus Retinitis;   Early-onset Schizophrenia Spectrum Disorders;   Edema;   Epilepsy;   General Anesthesia;   Gynecologic Infections;   Headaches;   Herpes Simplex Virus;   Hypertension;   Infantile Hemangioma;   Infection;   Inflammation;   Inflammatory Conditions;   Influenza;   Intra-abdominal Infections;   Lower Respiratory Tract Infections;   Migraines;   Pain;   Pneumonia;   Prophylaxis;   Schizophrenia;   Sedation;   Seizures;   Skeletal Muscle Spasms;   Skin and Skin-structure Infections;   Stable Angina;   Thromboprophylaxis;   Thrombosis;   Treatment-resistant Schizophrenia;   Urinary Tract Infection;   Withdrawal
Intervention:   Drug: The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
Sponsors:   Daniel Benjamin;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   The EMMES Corporation;   OpAns, LLC
Recruiting - verified March 2017

Stress Echocardiography and Heart Computed Tomography (CT) Scan in Emergency Department Patients With Chest Pain

Conditions:   Chest Pain;   Angina;   Angina Pectoris;   Coronary Artery Disease
Interventions:   Procedure: Stress Echocardiography;   Procedure: Coronary CT Angiography
Sponsors:   Montefiore Medical Center;   American Heart Association
Completed - verified March 2017

Drug Drug Interactions of Aspirin and P2Y12-inhibitors

Conditions:   Drug Interaction Potentiation;   Myocardial Infarction
Interventions:   Drug: Morphine;   Drug: Placebo
Sponsor:   Medical University of Vienna
Completed - verified March 2017

Nitroglycerin in Non-small Cell Lung Cancer

Condition:   Non Small Cell Lung Cancer (NSCLC)
Intervention:   Drug: Nitroglycerin patch
Sponsors:   Maastricht Radiation Oncology;   Reliable Cancer Therapies;   Anticancer Fund, Belgium
Completed - verified September 2016

Effect of Enhanced External Counterpulsation (EECP) on Subclinical Atherosclerosis

Condition:   Atherosclerosis
Interventions:   Device: Enhanced External Counterpulsation (EECP);   Drug: Simvastatin
Sponsor:   Yan Zhang
Recruiting - verified March 2017

The Effects of Vitamin K2 Supplementation on the Progression of Coronary Artery Calcification

Condition:   Coronary Artery Disease
Interventions:   Dietary Supplement: Menaquinone-7 (Vitamin K2);   Other: Placebo capsules
Sponsors:   Maastricht University Medical Center;   VitaK
Recruiting - verified March 2016

The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Darapladib 160 mg;   Drug: Placebo;   Other: Standard Therapy
Sponsors:   GlaxoSmithKline;   The TIMI Study Group
Completed - verified March 2017

Aerobic Interval Training in Cardiac Rehabilitation

Conditions:   Myocardial Infarction;   Coronary Artery Disease
Intervention:   Other: Exercise training
Sponsors:   Norwegian University of Science and Technology;   St. Olavs Hospital
Completed - verified March 2017

Long-term Evaluation of Patients Receiving Bone Marrow-derived Cell Administration for Heart Disease

Conditions:   Acute Myocardial Infarction;   Ischemic Cardiomyopathy;   Dilated Cardiomyopathy;   Heart Failure
Intervention:   Biological: autologous bone marrow-derived cells
Sponsor:   Johann Wolfgang Goethe University Hospital
Active, not recruiting - verified March 2017

Assessment of Clinical Performance and Costs of the Endeavor Resolute Stent "in Real Life" in Spain.

Condition:   Coronary Artery Disease
Intervention:   Device: Endeavor Resolute Stent
Sponsor:   Medtronic Bakken Research Center
Completed - verified February 2012

Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction

Condition:   Cardiovascular Disease
Intervention:   Procedure: Cardiac MRI
Sponsors:   Cedars-Sinai Medical Center;   National Heart, Lung, and Blood Institute (NHLBI);   University of Florida;   University of Pittsburgh
Active, not recruiting - verified March 2017

The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial

Condition:   Atherosclerosis
Interventions:   Drug: Darapladib;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Completed - verified March 2017

Fondaparinux Trial With Unfractionated Heparin (UFH) During Revascularization in Acute Coronary Syndromes (ACS)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: fondaparinux background and standard dose UFH;   Drug: Fondaparinux background and low dose heparin;   Drug: Open label fondaparinux
Sponsor:   GlaxoSmithKline
Completed - verified March 2017

The Effects of Traditional Acupuncture on Mechanisms of Coronary Heart Disease

Condition:   Coronary Artery Disease
Interventions:   Procedure: Traditional Acupuncture;   Procedure: AA
Sponsors:   Cedars-Sinai Medical Center;   National Center for Complementary and Integrative Health (NCCIH)
Completed - verified March 2017

Cardiac Magnetic Resonance Imaging (MRI) Normal Reference Control Group Testing

Condition:   Healthy
Intervention:   Other: Cardiac MRI
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified March 2017

Heart Disease of the Small Arteries in Women and Men

Condition:   Heart Disease
Intervention:   Procedure: noninvasive tests
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified March 2017

Whole Genome Association Study to Identify and Validate Genes for Restenosis: CardioGene Validation Proposal

Condition:   Coronary Restenosis
Intervention:  
Sponsor:   The Cleveland Clinic
Completed - verified March 2017

Cardiac Stem Cell Infusion in Patients With Ischemic CardiOmyopathy (SCIPIO)

Conditions:   Coronary Artery Disease;   Congestive Heart Failure
Intervention:   Biological: Treatment group
Sponsors:   University of Louisville;   Brigham and Women's Hospital;   Jewish Hospital and St. Mary's Healthcare
Completed - verified March 2017

ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study

Conditions:   Cardiovascular Disease;   Coronary Artery Calcification
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting - verified March 9, 2017

Cell Therapy in Myocardial Infarction

Condition:   Acute Myocardial Infarction
Intervention:   Procedure: Autologous Bone Marrow Mononuclear Cells (ABMMC) Transplantation
Sponsors:   Ministry of Health, Brazil;   Pro-Cardiaco Hospital;   Hospital do Coracao;   Instituto Estadual de Cardiologia Aloysio de Castro;   Hospital Cardiológico Costantini;   Hospital Universitário Regional do Norte do Paraná - FUEL;   Hospital Santa Izabel;   Hospital Santa Izabel de Sergipe;   Hospital Agamenon;   Hospital do Andaraí;   Hospital de Messejana;   Hospital de Clinicas de Porto Alegre;   Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto;   Instituto Nacional de Cardiologia de Laranjeiras;   Instituto de Cardiologia do Rio Grande do Sul;   Hospital São Marcos;   Hospital Universitário Oswaldo Cruz - UPE;   Real Hospital Português de Beneficência;   Hospital Municipal Miguel Couto;   Anis Rassi Hospital, Brazil;   Federal University of São Paulo;   Instituto Dante Pazzanese de Cardiologia;   Universidade Federal do Rio de Janeiro;   Hospital Bandeirantes;   InCor Heart Institute;   Hospital Santa Isabel de Blumenau;   Federal University of Uberlandia;   Hospital TotalCor;   Hospital de Clínicas Mario Lioni;   Hospital de Clínicas de Niteroi
Terminated - verified March 2017

Cell-Wave Study: Combined Extracorporal Shock Wave Therapy and Intracoronary Cell Therapy in Chronic Ischemic Myocardium

Condition:   Congestive Heart Failure
Intervention:   Procedure: intracoronary stem cell therapy
Sponsor:   Johann Wolfgang Goethe University Hospital
Completed - verified March 2017

Rosiglitazone Versus a Sulfonylurea On Progression Of Atherosclerosis In Patients With Heart Disease And Type 2 Diabetes

Condition:   Atherosclerosis
Interventions:   Drug: Glipizide;   Drug: rosiglitazone maleate
Sponsor:   GlaxoSmithKline
Completed - verified March 2017

Technical Development of Cardiovascular Magnetic Resonance Imaging

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 9, 2017

Correlates of Angiographic Changes and Coronary Events

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Coronary Arteriosclerosis;   Heart Diseases
Intervention:  
Sponsors:   University of Southern California;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified March 2017