Coronary Artery Disease

Clinical Trial Finder

Many patients with coronary artery disease are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Vortioxetine in Patients With Major Depressive Disorder and Coronary Artery Disease

Conditions:   Major Depressive Disorder;   Coronary Artery Disease
Intervention:   Drug: Vortioxetine
Sponsors:   Thomas Jefferson University;   Takeda
Not yet recruiting - verified May 2015

HemoSonics-UVA HemoSonics-UVA Cardiac Surgery Clinical Study Protocol

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   University of Virginia;   Hemosonics, LLC
Recruiting - verified May 2015

Acute Vascular Response to Exercise in Women With Nonobstructive Coronary Artery Disease

Condition:   Nonobstructive Coronary Artery Disease
Intervention:   Other: Slow-paced walking
Sponsor:   University of Florida
Not yet recruiting - verified May 2015

Cardiovascular Epidemiology in Russian Federation

Conditions:   Hypertension;   Coronary Artery Disease;   Diabetes;   Heart Failure;   Smoking;   Lifestyle
Intervention:  
Sponsors:   Federal North-West Medical Research Centre;   National Research Center for Preventive Medicine;   Russian Cardiology Research and Production Center
Recruiting - verified May 2015

A Prospective, Single-Blinded, Multi-Center, Randomized, Controlled, Registered Clinical Trial on the Efficacy and Safety of Sirolimus-Eluting Stent (MiStent® System) in the Treatment of Patients With Coronary Heart Disease

Condition:   Coronary Heart Disease
Interventions:   Device: MiStentTM;   Device: TIVOLI
Sponsors:   Micell Technologies;   Hefei Life Science Medical Instruments Co. Ltd.;   Giant Med-Pharma Services Inc.;   CCRF Consulting Co., Ltd.
Not yet recruiting - verified May 2015

DESolve® X-Pand Global Post Market Registry

Condition:   Coronary Artery Stenosis
Intervention:   Device: PTCA - Desolve Scaffold
Sponsors:   Elixir Medical Corporation;   European Cardiovascular Research  Center
Recruiting - verified May 2015

Natural History of Atherosclerosis in Real-World Patients Underwent Computed Tomography Angiography

Conditions:   Coronary Atherosclerosis;   Coronary Artery Disease;   Radiocontrast-induced Thyroid Dysfunction;   Contrast-induced Nephropathy
Interventions:   Radiation: Coronary computed tomography angiography;   Radiation: Quantitative coronary angiography
Sponsors:   Ural State Medical Academy;   Ural Institute of Cardiology;   De Haar Research Foundation
Enrolling by invitation - verified May 2015

Ultrasound-guided Intermediate Cervical Plexus Block for Carotid Surgery

Condition:   Carotid Artery Stenosis
Intervention:   Procedure: Ultrasound-guided intermediate cervical plexus block
Sponsor:   Institut Mutualiste Montsouris
Completed - verified May 2015

Plasma and Platelet microRNAs in Clopidogrel Low Response Patients

Condition:   Coronary Artery Disease
Interventions:   Drug: Clopidogrel;   Drug: acetylsalicylic acid (ASA)
Sponsors:   The First Hospital of Nanjing Medical University;   National Natural Science Foundation of China
Not yet recruiting - verified May 2015

A Phase I Study to Assess Ebola Vaccines cAd3-EBO Z and MVA-EBO Z

Condition:   Ebola Virus Disease
Interventions:   Biological: MVA-EBO Z;   Biological: ChAd3-EBO Z
Sponsor:   University of Oxford
Recruiting - verified May 2015

Fenofibrate Treatment in SCI

Conditions:   Spinal Cord Injury;   Dyslipidemia
Interventions:   Drug: Fenofibrate;   Other: No intervention
Sponsor:   Department of Veterans Affairs
Active, not recruiting - verified May 2015

Factors Associated With Perioperative Outcomes in Non-emergency Surgery

Conditions:   Stroke;   Acute Coronary Syndrome;   Pneumonia
Intervention:   Other: stroke or myocardial infarction or pneumonia
Sponsors:   University of Nottingham;   University of Wisconsin, Madison
Completed - verified May 2015

Acute Safety, Deliverability and Efficacy of the Medtronic Resolute Integrity™ Zotarolimus-Eluting Coronary Stent System in the Treatment of Suitable Patients According to Indication for Use (CHINA RESOLUTE INTEGRITY STUDY)

Conditions:   Ischemic Heart Disease;   Cardiovascular Diseases;   Arteriosclerosis;   Coronary Artery Disease
Intervention:   Device: Resolute Integrity™ Zotarolimus-Eluting Coronary Stent System
Sponsor:   Medtronic Vascular
Not yet recruiting - verified May 2015

Drug Coated Balloon Compared to Bare Metal Stent for de Novo Coronary Artery Lesions

Conditions:   Stable Angina;   Unstable Angina
Interventions:   Device: Drug Coated Balloon;   Device: Bare Metal Stent
Sponsors:   Ulsan University Hospital;   Seoul National University Hospital
Recruiting - verified May 2015

High-Sensitivity Troponin T Plasma Levels in Patients With Aortic Stenosis (Tyrolean Aortic Stenosis Study-2)

Conditions:   Aortic Stenosis;   Heart Failure;   Syncope;   Angina Pectoris
Intervention:   Procedure: Aortic Valve Intervention (surgical or transcatheter)
Sponsor:   Medical University Innsbruck
Not yet recruiting - verified May 2015

Effects of Nicorandil on Cardiac Infarct Size in Patients With ST-segment Elevation Acute Myocardial Infarction

Condition:   Myocardial Infarction
Intervention:   Drug: Nicorandil
Sponsors:   Pusan National University Hospital;   JW Pharmaceutical
Recruiting - verified May 2015

Verapamil vs Heparin in Transradial Procedures

Condition:   Heart Disease, Ischemic
Interventions:   Drug: Heparin;   Drug: Verapamil
Sponsor:   University Hospital of Ferrara
Recruiting - verified May 2015

The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome

Conditions:   Depression;   Acute Coronary Syndrome
Interventions:   Drug: Melatonin (N-acetyl-5-methoxytryptamine);   Drug: Placebo
Sponsors:   Roskilde County Hospital;   Psychiatric Research Unit, Region Zealand, Denmark;   University of Copenhagen;   Pharma Nord
Not yet recruiting - verified May 2015

Efficacy and Safety of BiomatrixTM Stent and 5mg-Maintenance Dose of Prasugrel in Patients With Acute Coronary Syndrome

Conditions:   Cardiac Death;   Hemorrhage;   Cerebrovascular Accident;   Myocardial Infarction
Interventions:   Device: BES (biodegradable polymer biolimus-eluting stent);   Drug: Prasugel;   Drug: Clopidogrel
Sponsor:   Chonnam National University Hospital
Recruiting - verified May 2015

Brilinta Taiwan Post Approval Safety Study

Condition:   Non ST-elevation Myocardial Infarction
Intervention:   Drug: Ticagrelor 180mg loading dose taken orally, followed by 90mg twice daily (bd)
Sponsor:   AstraZeneca
Recruiting - verified May 2015

High Inspiratory Oxygen Fraction on Endothelial Function in Healthy Volunteers

Condition:   Endothelial Dysfunction
Interventions:   Other: 80% oxygen;   Other: 30% oxygen
Sponsor:   University Hospital Koge
Completed - verified May 2015

The Use of Texting Messaging to Improve the Hospital-to-community Transition Period in Cardiovascular Disease Patients

Conditions:   Cardiovascular Disease;   Acute Coronary Syndrome
Intervention:   Behavioral: Txt2Prevent
Sponsors:   Simon Fraser University;   Providence Health & Services;   University of British Columbia;   McMaster University;   Canadian Institutes of Health Research  (CIHR)
Not yet recruiting - verified May 2015

Mechanistic Study of Bleeding Risk in Coronary Patients With Cerebrovascular Disease

Conditions:   Coronary Artery Disease;   Cerebral Stroke;   TIA (Transient Ischemic Attack)
Intervention:  
Sponsors:   University of Sao Paulo General Hospital;   Fundação de Amparo à Pesquisa do Estado de São Paulo
Recruiting - verified June 2014

Evaluation of Myocardial Perfusion Heterogeneity Imaging in Diabetes Patients (EVADIAB)

Condition:   Type 2 Diabetes
Intervention:   Device: MPHI
Sponsor:   University Hospital, Grenoble
Completed - verified May 2015

Liraglutide to Improve corONary Haemodynamics During Exercise streSS

Conditions:   Ischaemic Heart Disease;   Coronary Heart Disease;   Chronic Stable Angina
Interventions:   Drug: Liraglutide;   Other: Placebo
Sponsors:   King's College London;   Guy's and St Thomas' NHS Foundation Trust
Completed - verified May 2015

Palliative Care for Patients With Advanced Heart Disease

Conditions:   Acute Coronary Syndrome;   Congestive Cardiac Failure;   Palliative Care
Intervention:   Other: Palliative Care Intervention
Sponsor:   University of Edinburgh
Recruiting - verified May 2015

Is Glucagon-like Peptide-1 Insufficiency a Residual Risk in Coronary Artery Disease?

Condition:   Coronary Artery Disease
Intervention:   Other: Determination of plasma GLP-1 level
Sponsors:   Sapporo Medical University;   Merck Sharp & Dohme Corp.
Recruiting - verified May 2015

A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Acetylsalicylic acid;   Drug: Rivaroxaban;   Drug: Clopidogrel;   Drug: Ticagrelor
Sponsors:   Janssen Research & Development, LLC;   Bayer;   Duke Clinical Research Institute;   Harvard Medical School
Recruiting - verified May 2015

RuSsian RegisTry of Acute CoronaRy SyndromE TreAtMent and Approach in Dual Antiplatelet Therapy

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified May 2015

HI-VISION Pilot Study

Condition:   Postoperative Hypoxia
Intervention:   Other: ECG, blood pressure and oximetry
Sponsor:   McMaster University
Recruiting - verified May 2015

Prediction of Recurrent Events With 18F-Fluoride

Conditions:   Coronary Artery Disease;   Myocardial Infarction
Intervention:  
Sponsors:   University of Edinburgh;   NHS Lothian;   Oxford University Hospitals NHS Trust;   Central Manchester University Hospitals NHS Foundation Trust;   NHS Grampian;   Wellcome Trust
Not yet recruiting - verified May 2015

Rapid Assessment of Potential Ischaemic Heart Disease With CTCA

Condition:   Acute Coronary Syndrome
Intervention:   Radiation: CT Coronary Angiogram
Sponsors:   University of Edinburgh;   NHS Lothian
Recruiting - verified May 2015

Extension (OLE) Study to Assess Safety and Efficacy of Evolocumab

Condition:   Hypercholesterolemia
Intervention:   Biological: Evolocumab
Sponsor:   Amgen
Enrolling by invitation - verified May 2015

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified May 2015

Real Life Long-term Adherence to Ticagrelor After PCI for Acute Coronary Syndromes

Condition:   Acute Coronary Syndrome (ACS)
Intervention:   Drug: Ticagrelor
Sponsor:   IHF GmbH - Institut für Herzinfarktforschung
Active, not recruiting - verified May 2015

Eliminate Coronary Artery Disease

Condition:   Coronary Artery Disease
Intervention:   Drug: Atorvastatin
Sponsors:   University Health Network, Toronto;   Advanced Medical Research Institute of Canada
Recruiting - verified May 2015

Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

Conditions:   Stroke;   Secondary Prevention
Interventions:   Drug: optional ASA as comedication;   Drug: placebo to ASA;   Drug: placebo to optional ASA as comedication;   Drug: placebo to dabigatran etexilate;   Drug: ASA 100 mg;   Drug: dabigatran etexilate
Sponsor:   Boehringer Ingelheim
Recruiting - verified May 2015

PARACHUTE China Approval Trial

Condition:   Ischemic Heart Failure
Intervention:   Device: Parachute Implant
Sponsors:   CardioKinetix, Inc;   Guangzhou Chuangsi Medical Technology Co., Ltd.;   Peking University
Active, not recruiting - verified May 2015

MetfoRmin and Its Effects on Left Ventricular Hypertrophy in Normotensive Patients With Coronary Artery Disease

Conditions:   Left Ventricular Hypertrophy;   Insulin Resistance;   Coronary Artery Disease
Interventions:   Drug: Metformin XL;   Drug: Placebo
Sponsor:   University of Dundee
Recruiting - verified May 2015

Clinical Impact of Cytokine in Cardiac Surgery

Condition:   Coronary Disease
Intervention:  
Sponsor:   University Hospital of Cologne
Recruiting - verified May 2015

Study Of Costs Realized After Percutaneous Coronary intervenTion Employing Same Day Discharge

Condition:   Coronary Artery Disease
Intervention:   Procedure: Same day discharge
Sponsors:   Saint Joseph Mercy Health System;   Michigan Heart;   Blue Cross Blue Shield of Michigan Foundation
Suspended - verified May 2015

CONTRAST (Can cONTrast Injection Better Approximate FFR compAred to Pure reSTing Physiology?)

Condition:   Coronary Artery Disease
Interventions:   Drug: Adenosine;   Drug: Contrast Media;   Drug: Resting conditions
Sponsors:   The University of Texas Health Science Center, Houston;   St. Jude Medical
Completed - verified May 2015

Increasing Cardiac Rehabilitation Participation Among Medicaid Enrollees

Condition:   Coronary Artery Disease
Intervention:   Behavioral: Financial incentives
Sponsors:   University of Vermont;   National Institute of General Medical Sciences (NIGMS)
Recruiting - verified May 2015

PROSPECT II & PROSPECT ABSORB - an Integrated Natural History Study and Randomized Trial.

Condition:   Acute Coronary Syndrome (ACS)
Interventions:   Device: sham;   Device: ABSORB BVS
Sponsors:   Uppsala University;   Abbott Vascular;   Infraredx Inc;   The Medicines Company
Recruiting - verified May 2015

PET CT in Suspected CIED Infection, a Pilot Study - PET Guidance I

Conditions:   Complications;   Infective Endocarditis;   Implant Site Pocket Infection;   Fever of Unknown Origin
Intervention:   Other: PET CT
Sponsor:   Institute of Cardiology, Warsaw, Poland
Recruiting - verified May 2015

TandemHeart to Reduce Infarct Size (TRIS Trial)

Condition:   Acute Myocardial Infarction
Interventions:   Device: TandemHeart System;   Procedure: Percutaneous coronary intervention
Sponsor:   CardiacAssist, Inc.
Recruiting - verified May 2015

Prospective Observational Study of Trimetazidine Influence on Mitochondrial Metabolism in Human Heart Ventricle

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   University of Split, School of Medicine
Completed - verified May 2015

DLBS1033 for Acute NSTEMI Without Early Coronary Revascularization

Condition:   Acute Non-ST Elevation Myocardial Infarction
Interventions:   Drug: DLBS1033;   Drug: Placebo
Sponsor:   Dexa Medica Group
Not yet recruiting - verified May 2015

Evaluation of iFR vs FFR in Stable Angina or Acute Coronary Syndrome

Conditions:   Angina Pectoris;   Acute Myocardial Infarction
Interventions:   Device: iFR;   Device: FFR
Sponsor:   Uppsala University
Recruiting - verified May 2015

Progression of Coronary Atherosclerosis in Asymptomatic Diabetic Subjects

Conditions:   Type 2 Diabetes;   Coronary Artery Disease
Intervention:  
Sponsors:   British Cardiac Research Trust;   Royal Free Hospital NHS Foundation Trust;   London North West Healthcare NHS Trust;   Barnet and Chase Farm Hospitals NHS Trust;   Diabetes and Obesity Research Network;   Lund University;   Health Diagnostic Laboratory, Inc.
Recruiting - verified May 2015

Observational Prospective Study OPTIMA II - Follow-up

Condition:   Major Adverse Cardiovascular and Cerebrovascular Events (MACCE)
Intervention:  
Sponsor:   AstraZeneca
Completed - verified May 2015

Comprehensive Lifestyle Modification for Patients With Hypertension and Metabolic Syndrome: a Multicenter Randomized Controlled Trial

Conditions:   Hypertension;   Metabolic Syndrome
Interventions:   Behavioral: Comprehensive Lifestyle Modification;   Behavioral: DASH
Sponsors:   Universität Duisburg-Essen;   Kliniken Essen-Mitte;   Immanuel Hospital Berlin, Berlin, Germany;   Charité University Medical Center, Berlin, Germany;   University of Witten/Herdecke
Active, not recruiting - verified May 2015

A Phase 2b Study of CSL112 in Subjects With Acute Myocardial Infarction.

Condition:   Acute Myocardial Infarction
Interventions:   Biological: CSL112;   Biological: Placebo
Sponsor:   CSL Behring
Recruiting - verified May 2015

Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in Europe

Conditions:   Coronary Artery Disease;   Myocardial Infarction;   Dilated Cardiomyopathy;   Implantable Defibrillator User
Intervention:  
Sponsor:   University Medical Center Goettingen
Recruiting - verified May 2015

Impact of Continuous Positive Airway Pressure (CPAP) Therapy on Outcomes in Patients Undergoing Coronary Revascularization

Conditions:   Obstructive Sleep Apnea;   Ischaemic Heart Desease
Intervention:   Device: CPAP
Sponsor:   Beijing Anzhen Hospital
Recruiting - verified March 2014

Cologne Register of Wearable Defibrillator (CRWD)

Conditions:   Myocardial Infarction;   Ventricular Dysfunction;   Myocarditis
Intervention:  
Sponsors:   University of Cologne;   Zoll Medical Corporation
Recruiting - verified May 2015

Autologous Bone Marrow Mononuclear Cells in the Combined Treatment of Coronary Heart Disease

Condition:   Ischemic Heart Disease
Intervention:   Procedure: coronary artery bypass grafting with administration of autologous bone marrow stem cells
Sponsor:   St. Petersburg State Pavlov Medical University
Recruiting - verified September 2014

Swedish Drug-elution Trial in Peripheral Arterial Disease

Conditions:   Peripheral Arterial Disease;   Critical Limb Ischemia;   Intermittent Claudication
Interventions:   Procedure: Revascularization with drug-eluting technology;   Procedure: Revascularization without drug-eluting technology;   Device: drug-coated balloons and/or drug-eluting stents
Sponsors:   Sahlgrenska University Hospital, Sweden;   The Swedish Research Council;   Swedish Heart Lung Foundation;   Uppsala University;   The Swedish National Registry for Vascular Surgery
Recruiting - verified May 2015

Vascular Inflammation Imaging Using Somatostatin Receptor Positron Emission Tomography

Conditions:   Atherosclerosis;   Stroke;   Transient Ischemic Attack;   Chronic Stable Angina;   Acute Coronary Syndrome
Intervention:  
Sponsor:   University of Cambridge
Recruiting - verified May 2015

Compare Efficacy and Safety of Clopidogrel vs Ticagrelor in Stabilized Patients With Acute Myocardial Infarction After Percutaneous Coronary Intervention; TicAgrelor Versus CLOpidogrel in Stabilized Patients With Acute Myocardial Infarction: TALOS-AMI

Condition:   Acute Myocardial Infarction
Interventions:   Drug: Ticagrelor;   Drug: Clopidogrel
Sponsors:   Ki-Bae Seung;   Chonnam National University Hospital
Recruiting - verified May 2015

A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Ticagrelor 90 mg;   Drug: Ticagrelor placebo
Sponsor:   AstraZeneca
Recruiting - verified May 2015

Genotype Guided Versus Conventional Approach in Selection of Oral P2Y12 Receptor Blocker in Chinese Patients Suffering From Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Clopidogrel;   Drug: Ticagrelor
Sponsor:   The University of Hong Kong
Recruiting - verified May 2015

To Study the Safety and Clinical Outcomes of the Absorb Bioresorbable Vascular Scaffold (BVS) System in Patients With de Novo Lesions in Previously Untreated Vessels

Conditions:   Coronary Disease;   Coronary Artery Disease;   Coronary Restenosis
Intervention:   Device: Absorb BVS
Sponsor:   Abbott Vascular
Recruiting - verified May 2015

Effect of Garlic Tablet Some Indicators Related to Atherosclerosis

Condition:   Coronary Artery Disease
Intervention:   Dietary Supplement: Garlic
Sponsor:   Shahid Beheshti University
Completed - verified September 2013

Exenatide for Myocardial Protection During Reperfusion Study

Condition:   Myocardial Infarction
Interventions:   Drug: Exenatide;   Drug: Placebo
Sponsors:   University Health Network, Toronto;   AstraZeneca
Recruiting - verified May 2015

Prevention of Cardiovascular Events by Antiplatelet Agents After Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified May 2015

A Clinical Evaluation of Absorb™ Bioresorbable Vascular Scaffold (Absorb™ BVS) System in Chinese Population ~ ABSORB CHINA Randomized Controlled Trial (RCT)

Conditions:   Coronary Artery Disease;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Stenosis
Interventions:   Device: XIENCE V EECSS;   Device: ABSORB BVS System
Sponsor:   Abbott Vascular
Active, not recruiting - verified May 2015

A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure

Conditions:   Heart Failure;   Coronary Artery Disease
Interventions:   Drug: Rivaroxaban;   Drug: Placebo;   Other: Standard of care for heart failure and coronary artery disease
Sponsors:   Janssen Research & Development, LLC;   Bayer
Recruiting - verified May 2015

Effects of N-acetyl Cysteine During Primary Percutaneous Coronary Intervention

Condition:   Acute ST Segment Elevation Myocardial Infarction
Interventions:   Drug: NAC;   Drug: Saline
Sponsor:   Suleyman Demirel University
Recruiting - verified October 2014

Cangrelor Prasugrel Transition Study

Condition:   Coronary Artery Disease
Interventions:   Drug: Cangrelor;   Drug: Prasugrel
Sponsor:   The Medicines Company
Completed - verified May 2015

Portuguese Study on The Evaluation of FFR Guided Treatment of Coronary Disease

Condition:   Coronary Artery Disease
Intervention:   Device: Fractional flow reserve (St. Jude Medical pressure-wire)
Sponsors:   Portuguese Society of Cardiology;   Portuguese Association of Interventional Cardiology;   St. Jude Medical
Completed - verified May 2015

CRAGS (Coronary aRtery diseAse in younG adultS)

Conditions:   Coronary Artery Disease;   Acute Coronary Syndromes;   Young Patient;   Percutaneous Coronary Intervention;   Coronary Artery Bypass Grafting
Intervention:  
Sponsors:   University of Turku;   Finnish Foundation for Cardiovascular Research
Active, not recruiting - verified May 2015

Effects of N-acetyl Cysteine During Percutaneous Coronary Intervention

Condition:   Coronary Artery Disease
Interventions:   Drug: N-acetyl cysteine;   Drug: Saline
Sponsor:   Suleyman Demirel University
Recruiting - verified October 2014

Validation of Myocardial Perfusion Imaging

Condition:   Coronary Artery Disease
Intervention:   Procedure: coronary angiography
Sponsor:   University Hospital, Grenoble
Completed - verified May 2015

Angina Prevalence and Provider Evaluation of Angina Relief

Condition:   Stable Coronary Artery Disease (CAD).
Intervention:  
Sponsors:   Saint Luke's Health System;   Gilead Sciences
Enrolling by invitation - verified May 2015

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab SAR236553 (REGN727)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Other: placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified May 2015

Phase III Trial of Dantonic® (T89) Capsule to Prevent and Treat Stable Angina

Condition:   Angina Pectoris
Interventions:   Drug: T89 high dose;   Drug: T89 Low dose;   Drug: Sanqi+Bingpian;   Drug: Placebo
Sponsor:   Tasly Pharmaceuticals, Inc.
Recruiting - verified May 2015

Efficacy of Physical Exercise in Cardiac Rehabilitation

Conditions:   Coronary Heart Disease;   Heart Failure;   Ischemic Heart Diseases
Interventions:   Other: Supervised physical exercise training x3 weekly for 12 weeks;   Other: Supervised physical exercise training x2 weekly for 8 weeks
Sponsors:   Aarhus University Hospital Skejby;   Institute for Clinical and Experimental Medicine
Completed - verified May 2015

A Pivotal Trial to Establish the Efficacy and Long-term Safety of the Parachute Implant System

Conditions:   Congestive Heart Failure;   Left Ventricular (LV) Systolic Dysfunction
Intervention:   Device: CardioKinetix Parachute Implant and All Appropriate Medical Therapy (AAMT)
Sponsor:   CardioKinetix, Inc
Recruiting - verified May 2015

Meta-analyses of Fructose-containing Sugars and Incident Cardiometabolic Disease

Conditions:   Overweight;   Obesity;   Dyslipidemia;   Hyperlipidemia;   Diabetes;   Prediabetes;   Dysglycemia;   Gout;   Hypertension;   Metabolic Syndrome;   Coronary Heart Disease;   Cardiovascular Disease
Intervention:  
Sponsors:   John Sievenpiper;   Calorie Control Council;   Canada Research Chairs Endowment of the Federal Government of Canada;   Canadian Institutes of Health Research  (CIHR)
Active, not recruiting - verified May 2015

A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Brilinta

Condition:   Acute Coronary Syndromes
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified May 2015

Basel Stent Kosten Effektivitäts Trial Drug Eluting Balloons vs. Drug Eluting Stents in Small Vessel Interventions

Condition:   Coronary Heart Disease
Interventions:   Device: Drug eluting balloon;   Device: Drug eluting stent
Sponsors:   University Hospital, Basel, Switzerland;   Clinical Trial Unit, University Hospital Basel, Switzerland
Recruiting - verified May 2015

Natural History of Carotid Atherosclerosis

Conditions:   Carotid Artery Disease;   Stroke;   Myocardial Infarction;   Angina Pectoris
Intervention:  
Sponsor:   University of Athens
Recruiting - verified May 2015

Evaluating Cardiovascular Phenotypes Using Induced Pluripotent Stem Cells

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   Scripps Translational Science Institute
Enrolling by invitation - verified May 2015

Antazoline in Rapid Cardioversion of Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Interventions:   Drug: antazoline;   Drug: 0.9% saline
Sponsor:   Institute of Cardiology, Warsaw, Poland
Completed - verified May 2015

Efficacy and Safety of Targeted Intramyocardial Delivery of Auto CD34+ Stem Cells for Improving Exercise Capacity in Subjects With Refractory Angina

Conditions:   Chronic Myocardial Ischemia;   Refractory Angina Pectoris;   (Advanced) Coronary Heart Disease
Interventions:   Biological: Auto-CD34+ cells;   Biological: Placebo: Diluent used to suspend Auto-CD34+ cells;   Other: Standard of care
Sponsor:   Baxter Healthcare Corporation
Active, not recruiting - verified May 2015

Cyclosporine and Prognosis in Acute Myocardial Infarction (MI) Patients

Condition:   ST Elevation Acute Myocardial Infarction
Interventions:   Drug: Injection of Cyclosporin;   Drug: Placebo;   Procedure: Echocardiography
Sponsor:   Hospices Civils de Lyon
Active, not recruiting - verified April 2015

Efficacy of LCQ908 on Cardiovascular Risk

Conditions:   Coronary Artery Disease;   Hypertriglyceridemia
Interventions:   Drug: LCQ908;   Drug: Placebo
Sponsor:   Novartis Pharmaceuticals
Terminated - verified May 2015

Allopurinol in Acute Coronary Syndrome

Condition:   Chronic Stable Angina
Interventions:   Drug: Allopurinol;   Drug: Allopurinol;   Drug: Placebo
Sponsors:   Stephen McSwiggan;   British Heart Foundation
Terminated - verified May 2015

Plasmonic Photothermal and Stem Cell Therapy of Atherosclerosis Versus Stenting

Conditions:   Coronary Artery Disease;   Atherosclerosis
Interventions:   Other: Stenting and micro-infusion of NP;   Device: Implantation of everolimus-eluting stent
Sponsors:   Ural State Medical Academy;   Ural Institute of Cardiology;   De Haar Research Foundation;   Ural Federal University
Terminated - verified May 2015

Intramyocardial Multiple Precision Injection of Bone Marrow Mononuclear Cells in Myocardial Ischemia

Condition:   Heart Failure
Interventions:   Procedure: NOGA XP Cardiac Navigation System;   Procedure: NOGA XP Cardiac Navigation System
Sponsor:   Federal North-West Medical Research Centre
Recruiting - verified January 2014

Trial of an Internet-based Platform for Managing Chronic Diseases at a Distance

Conditions:   Ischemic Heart Disease;   Heart Failure;   Chronic Kidney Disease;   Diabetes;   Chronic Obstructive Pulmonary Disease
Intervention:   Behavioral: iCDM
Sponsors:   Simon Fraser University;   Canadian Institutes of Health Research  (CIHR);   Michael Smith Foundation for Health Research
Active, not recruiting - verified May 2015

Ranibizumab and the Risk of Arterial Thromboembolic Events

Conditions:   Age-related Macular Degeneration;   Coronary Artery Disease;   Cerebrovascular Disorders
Interventions:   Drug: 0.5 mg of ranibizumab;   Procedure: 0.5 mg of ranibizumab + photodynamic therapy;   Other: Sham injection
Sponsors:   Ural State Medical Academy;   Ural Institute of Cardiology;   De Haar Research Foundation
Terminated - verified May 2015

Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)

Condition:   Atherosclerosis
Interventions:   Drug: Canakinumab;   Drug: Placebo
Sponsor:   Novartis Pharmaceuticals
Active, not recruiting - verified May 2015

"Reversibility of Cardiovascular Injury With CPAP Use: Mechanisms Involved"

Conditions:   Sleep Apnea, Obstructive;   Hypoxia;   Hypercapnia;   Sleep Disorders;   Obesity;   Hypertension;   Coronary Artery Vasospasm;   Right Ventricular Overload;   Left Ventricular Function Systolic Dysfunction;   Ventricular Hypertrophy
Intervention:   Other: Clinically prescribed CPAP therapy
Sponsor:   University of Wisconsin, Madison
Completed - verified May 2015

Investigate Effect on Mean IMT of Probucol And/or CilosTazol in Patients With Coronary Heart dIsease Taking HMGCoA Reductase Inhibitor Therapy

Condition:   Hyperlipidemias
Interventions:   Drug: HMGCoA reductase inhibitor;   Drug: HMGCoA reductase inhibitor + probucol;   Drug: HMGCA reductase inhibitor + probucol + cilostazol
Sponsors:   Seoul National University Hospital;   Korea Otsuka Pharmaceutical Co.,Ltd.
Active, not recruiting - verified May 2015

International Survey of Acute Coronary Syndromes in Transitional Countries

Conditions:   Acute Coronary Syndrome;   Unstable Angina Pectoris;   Myocardial Infarction;   Coronary Disease
Intervention:  
Sponsor:   University of Bologna
Recruiting - verified May 2015

Invasive Revascularization or Not in Intermittent Claudication

Condition:   Intermittent Claudication
Interventions:   Procedure: INVASIVE (INV) treatment;   Other: Best medical treatment (BMT)
Sponsors:   Sahlgrenska University Hospital, Sweden;   Göteborg University
Active, not recruiting - verified May 2015

Boston Puerto Rican Health Study

Condition:   Cardiovascular Risk Factor
Intervention:  
Sponsors:   University of Massachusetts, Lowell;   National Heart, Lung, and Blood Institute (NHLBI);   National Institute on Aging (NIA);   Tufts University;   Northeastern University
Active, not recruiting - verified May 2015

Registry of Acute Coronary Syndromes in the Lazio Region of Italy

Condition:   Acute Coronary Syndromes
Intervention:  
Sponsors:   San Filippo Neri General Hospital;   Associazione Nazionale Medici Cardiologi Ospedalieri
Recruiting - verified May 2015

PROspective Multicenter Imaging Study for Evaluation of Chest Pain

Condition:   Chest Pain
Interventions:   Device: Coronary Angiography;   Device: Stress Echocardiogram;   Device: Nuclear Stress Test;   Device: Exercise Electrocardiogram
Sponsors:   Duke University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified March 2015

The Use of a Community-based Organization to Change Lifestyle Characteristics Related to Non Communicable Diseases

Conditions:   Diabetes;   Hypertension;   Stroke;   Ischemic Heart Disease
Intervention:   Behavioral: lifestyle modification
Sponsor:   University of Kelaniya
Completed - verified May 2015

16 Year Follow-up of the Erlangen Fitness and Prevention Study.

Conditions:   Osteoporosis;   Osteopenia;   Early Postmenopause
Intervention:   Procedure: physical exercise
Sponsors:   University of Erlangen-Nürnberg Medical School;   Behinderten und Rehabilitations-Sportverband Bayern;   Netzwerk Knochengesundheit e.V.
Active, not recruiting - verified May 2015

Detecting Heart Disease Using First Pass Imaging With Gated SPECT Perfusion

Condition:   Ischemic Heart Disease
Intervention:  
Sponsors:   Yale University;   Astellas Pharma US, Inc.
Completed - verified May 2015

FAME II - Fractional Flow Reserve (FFR) Guided Percutaneous Coronary Intervention (PCI) Plus Optimal Medical Treatment (OMT) Verses OMT

Condition:   Coronary Artery Disease
Interventions:   Other: Stenting plus OMT;   Other: Standard of care
Sponsor:   St. Jude Medical
Active, not recruiting - verified May 2015

Improving the Results of Heart Bypass Surgery Using New Approaches to Surgery and Medication

Condition:   Coronary Artery Disease
Interventions:   Procedure: No-touch SVG harvest vs conventional SVG harvest technique;   Dietary Supplement: Fish oil supplementation vs placebo
Sponsors:   Sunnybrook Health Sciences Centre;   Hamilton Health Sciences Corporation
Active, not recruiting - verified November 2011

The Healthy Elderly Longevity Cohort

Condition:   Healthy
Intervention:  
Sponsor:   Scripps Translational Science Institute
Recruiting - verified May 2015

Molecular and Morphologic Characterization of Circulating Endothelial Cells

Condition:   Acute Myocardial Infarction
Intervention:  
Sponsor:   Scripps Translational Science Institute
Recruiting - verified May 2015

Fibrinogen and Bleeding After Cardiac Surgery

Conditions:   Complications;   Bleeding;   Coronary Artery Disease
Intervention:   Drug: Fibrinogen
Sponsor:   Sahlgrenska University Hospital, Sweden
Completed - verified May 2015

Comparison of Individual Computer Aided Design/Manufactured (CAD/CAM) - Based Implants Consisting on Hydroxylapatite and Titanium to be Used in Cranioplasty

Conditions:   Skull Defects;   Cranioplasty
Interventions:   Device: Titanium implant (CranioConstruct™);   Device: Hydroxylapatite (CustomBone)
Sponsors:   University of Leipzig;   Klinik für Neurochirurgie Universitatsklinikum Leipzig AöR
Terminated - verified May 2015

Prochymal® (Human Adult Stem Cells) Intravenous Infusion Following Acute Myocardial Infarction (AMI)

Condition:   Myocardial Infarction
Interventions:   Drug: Prochymal®;   Drug: Placebo
Sponsor:   Mesoblast International Sàrl
Active, not recruiting - verified May 2015

A Clinical Evaluation of Everolimus Eluting Coronary Stents in the Treatment of Patients With ST-segment Elevation Myocardial Infarction: EXAMINATION Study

Condition:   Myocardial Infarction
Interventions:   Drug: Everolimus Eluting Coronary Stent System;   Device: cobalt chromium balloon expandable stent ( non drug eluting stent Arm)
Sponsor:   Spanish Society of Cardiology
Completed - verified May 2015

Trial of a Cardiac Rehabilitation Program Delivered Remotely Through the Internet

Condition:   Cardiovascular Disease
Intervention:   Behavioral: vCRP
Sponsors:   Simon Fraser University;   Heart and Stroke Foundation of Canada
Completed - verified May 2015

Effect of Exercise and Phytoestrogen on Bone, Metabolic Syndrome Criteria and Complaints of the Early Menopause

Conditions:   Bone Diseases;   Metabolic Syndrome X;   Coronary Disease
Interventions:   Behavioral: exercise;   Behavioral: exercise + cimicifuga racemosa;   Behavioral: wellness control, placebo
Sponsors:   University of Erlangen-Nürnberg Medical School;   Siemens-Betriebskrankenkasse
Terminated - verified May 2015

Insulin Resistance and Atherosclerosis in Women With Lupus

Conditions:   Systemic Lupus Erythematosus;   Insulin Resistance;   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Completed - verified May 2015

Understanding the Genetic Basis of Atherosclerosis and Peripheral Arterial Disease

Condition:   Peripheral Vascular Diseases
Intervention:  
Sponsors:   Stanford University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified May 2015

Post Conditioning in PCI for Acute ST Elevation Myocardial Infarction

Condition:   Myocardial Infarction
Intervention:   Procedure: Post conditioning
Sponsors:   University of Calgary;   Foothills Interventional Cardiology Research Group
Completed - verified May 2015

Safety Outcomes of Lower Immunosuppression Versus Traditional Immunosuppression in Heart Transplant Recipients

Condition:   Immunosuppression
Interventions:   Drug: Tacrolimus;   Drug: combination therapy
Sponsors:   Newark Beth Israel Medical Center;   Astellas Pharma Inc
Completed - verified May 2015

A Study Comparing the Efficacy and Safety of Abciximab, an Anti-Platelet Therapy, in Combination With Two Different Heparin Regimens in Patients Undergoing Percutaneous Coronary Intervention.

Condition:   Angioplasty, Transluminal, Percutaneous Coronary
Interventions:   Drug: Placebo;   Drug: Heparin;   Drug: Abciximab
Sponsor:   Centocor, Inc.
Completed - verified May 2015

Cardiovascular Risk Factor Management in HIV Infection

Conditions:   Coronary Heart Disease;   Dyslipidemia;   Diabetes Mellitus, Non-Insulin-Dependent;   HIV Infection
Interventions:   Behavioral: Updated CHD risk profiles;   Behavioral: Guidelines
Sponsors:   University Hospital, Basel, Switzerland;   Swiss National Science Foundation;   Bristol-Myers Squibb
Completed - verified May 2015

A Study Evaluating the Efficacy and Safety of Abciximab, an Anti-Platelet Therapy, in Patients With Unstable Angina Not Responding to Standard Medical Therapy Who Are Eligible for Coronary Angioplasty

Conditions:   Angina, Unstable;   Angioplasty, Transluminal, Percutaneous Coronary
Interventions:   Drug: Abciximab;   Drug: Placebo
Sponsor:   Centocor, Inc.
Completed - verified May 2015

Investigation of Leukocyte Trafficking Into Skin Blisters During Cardiopulmonary Bypass

Conditions:   Ischemic Heart Disease;   Angina Pectoris
Intervention:   Drug: Aprotinin
Sponsors:   Imperial College London;   British Heart Foundation
Completed - verified August 2005

Study to Examine the Safety and Effectiveness of Implanted Skeletal Muscle Cells (Cells Removed From the Thigh Muscle) Into Scarred Areas of Heart Muscle After Heart Attack.

Conditions:   Ischemic Heart Failure;   Ischemic Heart Disease;   Ischemic Cardiomyopathy
Intervention:   Drug: Cellular Therapy (Cultured Autologous Skeletal Myoblast Transplantation)
Sponsor:   Genzyme, a Sanofi Company
Terminated - verified May 2015

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