Coronary Artery Disease

Clinical Trial Finder

Many patients with coronary artery disease are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Assessment Of Total Coronary Circulation Time Using TIMI Frame Count Method (TCCT-TIMI)

Conditions:   Coronary Angiography;   Coronary Artery Disease;   Coronary Artery Ectasia;   Slow-Flow Phenomenon;   Coronary Heart Disease
Intervention:   Procedure: coronary angiography
Sponsors:   Vascular and Molecular Cardiology;   Private Yenisehir Hospital;   Private Gozde Hospital;   Gulhane Military Medical Academy
Not yet recruiting - verified June 2016

BIOTRONIKS - Safety and Performance in de NOvo Lesion of NatiVE Coronary Arteries With Magmaris- Registry: BIOSOLVE-IV

Condition:   Coronary Artery Disease
Intervention:   Device: Magmaris
Sponsor:   Biotronik AG
Not yet recruiting - verified June 2016

Tolerance of Myocardium to Ischemia Injury

Conditions:   Reperfusion Injury;   Myocardial Ischemia
Interventions:   Procedure: cardiac surgery scheduled in the morning;   Procedure: cardiac surgery scheduled in the afternoon
Sponsor:   University Hospital, Lille
Recruiting - verified June 2016

Role of Podocan and Wnt Pathway Regulatory Molecules in Coronary Artery Disease

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   Bassett Healthcare;   Baylor University
Not yet recruiting - verified June 2016

Study to Evaluate the Effect of Nicotinamide Riboside on Immunity

Conditions:   Atherosclerosis;   Diabetes;   Coronary Artery Disease
Interventions:   Dietary Supplement: Nicotinamide riboside (NR);   Other: Placebo
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified June 2016

Randomized Anticoagulation Trial in Opcab (RATIO)

Condition:   Ischemic Heart Disease
Intervention:   Drug: Heparin
Sponsor:   Azienda Ospedaliera di Lecco
Not yet recruiting - verified June 2016

SYNTAX III REVOLUTION Trial: A Randomized Study Investigating the Use of CT Scan and Angiography of the Heart to Help the Doctors Decide Which Method is the Best to Improve Blood Supply to the Heart in Patients With Complex Coronary Artery Disease

Conditions:   Coronary Artery Diseases;   Multivessel Coronary Artery Disease;   Heart Diseases;   Cardiovascular Diseases
Interventions:   Radiation: Coronary Angiography;   Radiation: Computed Tomography (CT) scan
Sponsors:   ECRI bv;   GE Healthcare;   HeartFlow, Inc.
Not yet recruiting - verified June 2016

Efficacy CompariSon of Pre-stenting Atherectomy Versus Scoring ballooN for calcifieD Coronary Lesions Coronary Lesions

Conditions:   Atherosclerosis;   Coronary Artery Disease
Interventions:   Device: Rotational atherectomy;   Device: Orbital atherectomy;   Device: Scoring balloon system
Sponsor:   North Texas Veterans Healthcare System
Enrolling by invitation - verified June 2016

The Effect of Remote Ischemic Preconditioning on Major Organ Function in Patients With Coronary Artery Disease Undergoing Orthopedic Surgery

Conditions:   Angina Pectoris;   Myocardial Infarction
Interventions:   Procedure: Remote ischemic preconditioning;   Procedure: Sham control
Sponsor:   Seoul National University Hospital
Not yet recruiting - verified June 2016

Machine leArning Based CT angiograpHy derIved FFR: a Multi-ceNtEr, Registry

Conditions:   Coronary Heart Disease;   Coronary Artery Disease
Intervention:  
Sponsors:   Erasmus Medical Center;   Asan Medical Center;   University Hospital, Linkoeping;   Institute of Cardiology, Warsaw, Poland;   Medical University of South Carolina;   Siemens Healthcare Diagnostics Inc
Active, not recruiting - verified June 2016

Liver Injury by Statins in Patients With History of Hepatitis B Virus Infection

Conditions:   Liver Injury;   Hepatitis B Virus Infection History
Intervention:   Other: HBV infection history
Sponsor:   The First Affiliated Hospital with Nanjing Medical University
Not yet recruiting - verified June 2016

Assessment of Coronary Artery Lesion Using Optical Coherence Tomography Versus IntraVascular Ultrasound for BiorEsorbable Vascular Scaffold Implantation

Condition:   Coronary Artery Disease
Interventions:   Other: Optical coherent tomography;   Other: IntraVascular UltraSound
Sponsors:   Young-Hak Kim, MD, PhD;   Abbott Vascular
Not yet recruiting - verified June 2016

Assessment of Myocardial Perfusion by Tomography and Scintigraphy in Patients With Cardiac Stress Test With Ischemia

Condition:   Myocardial Perfusion
Intervention:  
Sponsor:   University of Sao Paulo General Hospital
Not yet recruiting - verified June 2016

Dynamic Stress Perfusion ct for Detection of Inducible Myocardial Ischemia MYOCARDIAL ISCHEMIA

Condition:   Coronary Artery Disease
Intervention:   Other: Diagnostic detection of coronary artery disease
Sponsors:   Erasmus Medical Center;   University Hospital Tuebingen;   Siemens Medical Solutions;   Bayer;   University of Erlangen-Nürnberg;   University Medical Center Groningen;   National Institute for Health Research, United Kingdom;   Mie University;   Kobe University;   Massachusetts General Hospital;   Medical University of South Carolina;   University Hospital, Zürich
Recruiting - verified June 2016

OPTImizing Precision of Hypertension Care to Maximize Blood Pressure Control Pilot (OPTI-BP Pilot)

Condition:   High Blood Pressure
Interventions:   Other: HTN PRA App;   Other: Blood Sample
Sponsors:   University of Florida;   OneFlorida Clinical Research Consortium
Recruiting - verified June 2016

The Application of Multichannel ECG Analytic System in Cardiovascular Diseases

Condition:   Multichannel ECG System
Intervention:  
Sponsor:   National Taiwan University Hospital
Recruiting - verified June 2016

Impact of a Therapeutic Education Program of Patient on the Evolution of the Cardiovascular Chronic Disease

Conditions:   Stroke;   Myocardial Infarction
Interventions:   Other: Optimized conventional therapy alone;   Behavioral: Optimized conventional therapy with therapeutic education
Sponsor:   University Hospital, Bordeaux
Active, not recruiting - verified June 2016

Effect of Aerobic EXercise on MiCroVAscular RarefacTION in Chinese Mild HyperteNsive Patients(EXCAVATION-CHN1)

Condition:   Primary Hypertension
Interventions:   Behavioral: Aerobic Exercise;   Behavioral: Health Education
Sponsor:   First Affiliated Hospital, Sun Yat-Sen University
Recruiting - verified June 2016

Smartphone Delivered In-home Cardiopulmonary Rehabilitation

Conditions:   Cardiovascular Disease;   Coronary Artery Disease
Interventions:   Behavioral: MULTIFIT Cardiac Rehabilitation;   Behavioral: Movn Pulmonary Rehabilitation;   Behavioral: Standard of Care Cardiac Rehabilitation
Sponsor:   Emory University
Recruiting - verified May 2016

Investigation of the Role of Hemodynamics in Re-stenosis of CABG Patients

Conditions:   Coronary Artery Disease;   Stable Angina;   Unstable Angina
Interventions:   Other: Computed Tomography Angiography;   Other: Intra-operative graft flow rate measurement
Sponsor:   National Heart Centre Singapore
Active, not recruiting - verified May 2016

Reducing Acute Coronary Syndrome Patient Delay

Condition:   Acute Coronary Syndrome
Interventions:   Behavioral: Text+Visual BCT-based intervention;   Behavioral: Text-only BCT intervention;   Behavioral: Leaflet information (control)
Sponsors:   Edinburgh Napier University;   University of Stirling;   University of Aberdeen;   University of Dundee;   The University of New South Wales
Not yet recruiting - verified June 2016

Effects of Beta-blockade on Platelet Aggregation in Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Carvedilol;   Drug: Metoprolol
Sponsor:   Federico II University
Recruiting - verified June 2016

Post TAVI Coronary REVASCularisation Guided by Myocardial Perfusion Imaging: a Prospective Open Label Pilot Study: The REVASC-TAVI Study

Conditions:   Severe and Symptomatic Aortic Stenosis;   Stable Coronary Disease
Intervention:   Procedure: TAVI procedure
Sponsor:   University Hospital, Montpellier
Not yet recruiting - verified June 2016

Non-invasive Fractional Flow Reserve CT (FFRCT)Scan for the Study of Coronary Vaso-motion

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   National Heart Centre Singapore
Active, not recruiting - verified May 2016

Global CMR Registry

Condition:   Cardiovascular Diseases
Intervention:   Procedure: Cardiovascular Magnetic Resonance Imaging
Sponsor:   Society for Cardiovascular Magnetic Resonance
Active, not recruiting - verified June 2016

Multi- Level and Integrated Analysis of Mechanisms Underlying Atrial Dysfunction

Condition:   Ischemic Heart Disease
Intervention:   Procedure: Cardiac Bypass Surgery
Sponsors:   National Heart Centre Singapore;   Duke-NUS Graduate Medical School
Recruiting - verified May 2016

Comparison of Prasugrel and Ticagrelor in the Treatment of Acute Myocardial Infarction

Conditions:   Myocardial Infarction;   Angioplasty, Balloon, Coronary;   Platelet Aggregation Inhibitors
Interventions:   Drug: Prasugrel;   Drug: Ticagrelor
Sponsor:   Faculty Hospital Kralovske Vinohrady
Active, not recruiting - verified June 2016

Interest of CARE Rule to Exclude the Hypothesis of an Acute Coronary Syndrome Without Bioassay - ICARE

Condition:   Chest Pain
Intervention:   Other: CARE Rule
Sponsor:   University Hospital, Angers
Not yet recruiting - verified June 2016

APixaban vs. PhenpRocoumon in Patients With ACS and AF: APPROACH-ACS-AF

Conditions:   Acute Coronary Syndrome;   Atrial Fibrillation;   Coronary Artery Disease
Interventions:   Other: Dual Therapy;   Other: Triple Therapy
Sponsors:   Klinikum der Universitaet Muenchen;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK);   Technische Universität München;   Helmholtz Zentrum München;   University of Göttingen;   University of München;   University Medicine Greifswald
Not yet recruiting - verified May 2016

The Influence Cirrhosis of the Liver on the Coronary Re-stenosis (LTX- Stent Study)

Conditions:   Re-stenosis;   Cirrhosis of the Liver
Interventions:   Device: ZES;   Device: BMS
Sponsor:   RWTH Aachen University
Not yet recruiting - verified April 2016

The Impact of Post Stenting Balloon Dilatation on Coronary Microcirculation in STEMI Patients Undergoing PPCI

Condition:   ST-elevation Myocardial Infarction (STEMI)
Intervention:  
Sponsors:   Basildon and Thurrock University Hospitals NHS Foundation Trust;   Anglia Ruskin University
Recruiting - verified June 2016

Trhombus Aspiration in Hyperglycemic ST-elevation myocardiAl InfarcTIon

Condition:   Hyperglycemia
Intervention:   Device: percutaneous coronary intervention
Sponsor:   Second University of Naples
Enrolling by invitation - verified June 2016

Coronary Physiology and Its Relationship to Anatomy in Patients With Diabetes Mellitus

Conditions:   Diabetes Mellitus;   Coronary Artery Disease
Intervention:   Device: Pressure Wire Certus, St. Jude Medical, USA
Sponsor:   Ottawa Heart Institute Research Corporation
Recruiting - verified June 2016

Myocardial Protection With Phosphocreatine in High-RIsk Cardiac SurgEry Patients

Conditions:   Cardiac Surgical Procedures;   Heart Valve Prosthesis Implantation
Interventions:   Drug: Phosphocreatine sodium tetrahydrate after anaesthesia induction;   Drug: 5% Glucose after anaesthesia induction;   Drug: Phosphocreatine sodium tetrahydrate added to cardioplegia;   Drug: 5% Glucose;   Drug: Phosphocreatine sodium tetrahydrate after heart recovery;   Drug: 5% Glucose after heart recovery;   Drug: Phosphocreatine sodium tetrahydrate after ICU admission;   Drug: 5% Glucose after ICU admission
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Not yet recruiting - verified June 2016

Relationship Between Left Ventricular Remodeling, Coronary Endothelial Function and Myocardial Fibrosis Using Positron Emission Tomography in Patients With ST-elevation Myocardial Infarction

Condition:   ST Elevation Myocardial Infarction
Intervention:   Other: (15)-O water positron emission tomography and Biomarkers
Sponsors:   University Hospital, Caen;   Société Française de Cardiologie
Not yet recruiting - verified June 2016

Intraoperative Nasal Insulin Effect on Plasma and CSF Insulin Concentration and Blood Glucose

Conditions:   Ischemic Heart Disease;   Aortic Aneurysm
Interventions:   Drug: Humulin R;   Drug: Normal Saline
Sponsor:   Hiroaki Sato, MD., PhD.
Not yet recruiting - verified June 2016

Safety and Feasibility of Intracoronary Hypothermia in Acute Myocardial Infarction

Condition:   Myocardial Infarction
Intervention:   Other: intracoronary infusion with saline on 22 and 4°C
Sponsor:   Catharina Ziekenhuis Eindhoven
Recruiting - verified June 2016

A Study of CSL112 in Adults With Moderate Renal Impairment and Acute Myocardial Infarction

Condition:   Acute Myocardial Infarction
Interventions:   Biological: CSL_112;   Other: Placebo
Sponsor:   CSL Behring
Not yet recruiting - verified June 2016

Chewing Versus Traditional Oral Administration of Ticagrelor in STEMI Patients

Conditions:   Acute Coronary Syndromes;   ST Elevation Myocardial Infarction
Interventions:   Drug: Chewing Ticagrelor;   Drug: Oral Ticagrelor
Sponsor:   Sheba Medical Center
Recruiting - verified April 2016

Assessing the Efficacy of CARDIOgoniometry (CGM) to Determine Physiologically Significant Stenosis in Patients With Stable Coronary Artery Disease in Comparison to Fractional FLOW Reserve - CARDIOFLOW

Condition:   Coronary Artery Disease
Interventions:   Device: Cardiogoniometry (CGM);   Device: Fractional Flow Reserve (FFR)
Sponsor:   Hull and East Yorkshire Hospitals NHS Trust
Recruiting - verified June 2016

GLP-1 and Hyperoxia for Organ Protection in Heart Surgery

Conditions:   Coronary Disease;   Shock, Cardiogenic;   Renal Failure;   Stroke;   Brain Injury;   Aortic Valve Disease
Interventions:   Drug: Byetta (Lilly, Exenatide);   Drug: Conoxia (AGA, oxygen);   Drug: 20% Human Albumin
Sponsor:   Rigshospitalet, Denmark
Recruiting - verified June 2016

Optimizing Timing of CABG in Patients Presenting With ACS and Treated With Ticagrelor

Condition:   Coronary Artery Disease
Interventions:   Procedure: PRU guided CABG;   Procedure: CABG per standard of care;   Device: VerifyNow assay;   Drug: Ticagrelor
Sponsor:   St. Michael's Hospital, Toronto
Recruiting - verified June 2016

Clinical Performance Evaluation of AQT90 FLEX TnI and TnT

Condition:   Myocardial Infarction
Intervention:  
Sponsor:   Radiometer Medical ApS
Recruiting - verified June 2016

Randomized-controlled Trial of a Combined vs. Conventional Percutaneous Intervention for Near-Infrared Spectroscopy Defined High-Risk Native Coronary Artery Lesions

Conditions:   Arteriosclerosis;   Near-infrared Spectroscopy;   Peri-procedural Myocardial Infarction;   Coronary Artery Disease
Interventions:   Procedure: Combined Intervention;   Procedure: Conventional PCI
Sponsor:   North Texas Veterans Healthcare System
Terminated - verified June 2016

Testing a Community Intervention to Increase Aspirin Use

Conditions:   Myocardial Infarction;   Stroke
Interventions:   Other: Mass Media plus clinic intervention.;   Other: Media
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Recruiting - verified June 2016

Exercise Training in Patients With Atrial Fibrillation (OPPORTUNITY Study)

Condition:   Atrial Fibrillation
Interventions:   Behavioral: moderate-intensity continuous exercise training;   Behavioral: high-intensity interval training
Sponsor:   Ottawa Heart Institute Research Corporation
Recruiting - verified June 2016

"Me and My Heart" Study

Condition:   Acute Coronary Syndrome
Interventions:   Device: Active group with MEMS;   Device: Active group without MEMS;   Device: Control group with MEMS;   Device: Control group without MEMS
Sponsor:   AstraZeneca
Recruiting - verified June 2016

WISE CVD - Continuation (WISE HFpEF)

Conditions:   Microvascular Coronary Dysfunction;   Cardiovascular Disease
Interventions:   Procedure: Coronary Angiography;   Procedure: Coronary Reactivity Testing;   Procedure: Cardiac Magnetic Resonance Imaging;   Procedure: Cardiac Magnetic Resonance Angiography;   Procedure: Computed Coronary Tomographic Angiography;   Procedure: Rest-Stress Millar Testing;   Procedure: Aortic vasorelaxation tests
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified June 2016

Safety of PZ-128 in Subjects Undergoing Non-Emergent Percutaneous Coronary Intervention

Conditions:   Arterial Occlusive Diseases;   Coronary Artery Disease;   Coronary Disease;   Arteriosclerosis;   Heart Diseases;   Myocardial Ischemia;   Vascular Diseases;   Acute Coronary Syndrome
Interventions:   Drug: PZ-128;   Drug: Placebo
Sponsors:   Tufts Medical Center;   National Heart, Lung, and Blood Institute (NHLBI);   RTI International;   Inova Fairfax Hospital;   University of Massachusetts, Worcester
Recruiting - verified June 2016

Epidemiological Study on the Safety of Aspirin in The Health Improvement Network (THIN)

Conditions:   Secondary Prevention;   Stroke;   Ischemic Heart Disease;   Coronary Heart Disease
Interventions:   Drug: Acetylsalicylic Acid (Asprin, BAYE4465);   Drug: Clopidogrel, Oral Anticoagulants, NSAIDs and SSRIs
Sponsor:   Bayer
Recruiting - verified June 2016

Safety and Efficacy of the Combo Bio-engineered Sirolimus-eluting Stent Versus the Nano Polymer-free Sirolimus-eluting Stent in the Treatment of Patients With de Novo Stenotic Lesions

Condition:   Coronary Arteriosclerosis
Interventions:   Device: OrbusNeich Combo stent™;   Device: sirolimus-eluting stent system
Sponsors:   OrbusNeich;   CCRF Inc., Beijing, China;   OrbusNeich Medical (Shenzhen), Co. Ltd.
Active, not recruiting - verified June 2016

Utility of a Smart Phone Application in Assessing Radial Artery Patency - the CAPITAL iRADIAL Study

Condition:   Coronary Heart Disease
Interventions:   Other: Modified Allen Test;   Other: Iphone artery assessment
Sponsor:   Ottawa Heart Institute Research Corporation
Completed - verified June 2016

Prevalence of Chronic Kidney Disease and Its Association With Clinical Outcome in Patients With Coronary Heart Disease

Conditions:   Coronary Heart Disease;   Chronic Kidney Disease
Intervention:  
Sponsors:   Peking University First Hospital;   Pfizer
Recruiting - verified June 2016

Effect of Dalcetrapib vs Placebo on CV Risk in a Genetically Defined Population With a Recent ACS

Condition:   Acute Coronary Syndrome
Interventions:   Drug: dalcetrapib;   Drug: Placebo
Sponsors:   DalCor Pharmaceuticals;   The Montreal Health Innovations Coordinating Center (MHICC);   Medpace, Inc.;   Roche Molecular Systems, Inc
Recruiting - verified June 2016

VEST III PMS Clinical Protocol

Condition:   Coronary Artery Disease
Interventions:   Device: VEST External Support;   Procedure: Coronary Artery Bypass Surgery
Sponsor:   Vascular Graft Solutions Ltd.
Recruiting - verified June 2016

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Recruiting - verified June 2016

Aspirin Twice a Day in Patients With Diabetes and Acute Coronary Syndrome

Conditions:   Diabetes Mellitus;   Acute Coronary Syndrome;   Coronary Artery Disease
Interventions:   Drug: Novel strategy Aspirin;   Drug: Conventional strategy Aspirin
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Bayer
Recruiting - verified June 2016

Stress Ulcer Prophylaxis in the Intensive Care Unit

Conditions:   Gastrointestinal Bleeding;   Stress Ulcers
Interventions:   Drug: Pantoprazole;   Other: Saline (0.9%)
Sponsors:   Dr. Morten Hylander Møller;   Rigshospitalet, Denmark;   Copenhagen Trial Unit, Center for Clinical Intervention Research
Recruiting - verified June 2016

VIDA Mobile Health Cardiovascular Prevention Program

Condition:   Coronary Artery Disease
Intervention:   Behavioral: Mobile Health Application
Sponsors:   Duke University;   Vida Health, Inc.;   Duke Health (Duke Heart Center)
Recruiting - verified June 2016

Verapamil vs Heparin in Transradial Procedures

Condition:   Heart Disease, Ischemic
Interventions:   Drug: Heparin;   Drug: Verapamil
Sponsor:   University Hospital of Ferrara
Active, not recruiting - verified June 2016

A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart

Condition:   Acute Coronary Syndromes
Interventions:   Drug: Apixaban;   Drug: vitamin K antagonist;   Drug: Acetylsalicylic acid;   Other: Acetylsalicylic acid placebo
Sponsors:   Bristol-Myers Squibb;   Pfizer;   Duke Clinical Research Institute
Recruiting - verified May 2016

COMBinAtion Therapy in Myocardial Infarction: The COMBAT-MI Trial

Condition:   ST Elevation Acute Myocardial Infarction
Interventions:   Drug: Exenatide;   Other: Remote Ischemic Conditioning (RIC);   Drug: Placebo
Sponsor:   Hospital Universitari Vall d'Hebron Research Institute
Recruiting - verified March 2016

Frailty in Elderly Patients Receiving Cardiac Interventional Procedures

Condition:   Aged
Intervention:   Other: frailty evaluation
Sponsor:   University Hospital of Ferrara
Recruiting - verified March 2016

High Fidelity Simulation vs Standard Teaching Training of Cardiac Resuscitation

Condition:   Cardiac Arrest
Interventions:   Device: Laerdal®;   Behavioral: huma patient based training;   Behavioral: traditionally teaching
Sponsor:   University of Monastir
Completed - verified June 2016

Benefits of Exercise Training in Women With Ischemic Syndrome

Condition:   Microvascular Coronary Dysfunction
Intervention:   Behavioral: Exercise training
Sponsor:   Cedars-Sinai Medical Center
Not yet recruiting - verified June 2016

Impact of Hyperoxia During Cardiopulmonary

Condition:   Cardiac Complications
Intervention:   Drug: medical oxygen
Sponsor:   Centre Hospitalier Universitaire, Amiens
Recruiting - verified June 2016

Integrated RF and B-mode Deformation Analysis for 4D Stress Echocardiography

Condition:   Coronary Artery Disease
Intervention:   Procedure: Stress Dobutamine Echocardiographic using 4DE System
Sponsor:   Yale University
Not yet recruiting - verified June 2016

A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Acetylsalicylic acid;   Drug: Rivaroxaban;   Drug: Clopidogrel;   Drug: Ticagrelor
Sponsors:   Janssen Research & Development, LLC;   Bayer;   Duke Clinical Research Institute;   Harvard Medical School
Recruiting - verified June 2016

NIRS Ticagrelor Evaluation

Condition:   Coronary Artery Disease
Intervention:   Drug: Ticagrelor
Sponsors:   Medstar Research Institute;   AstraZeneca
Completed - verified June 2016

Extension (OLE) Study to Assess Safety and Efficacy of Evolocumab

Condition:   Hypercholesterolemia
Intervention:   Biological: Evolocumab
Sponsor:   Amgen
Enrolling by invitation - verified June 2016

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified June 2016

Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source (RE-SPECT ESUS)

Conditions:   Stroke;   Secondary Prevention
Interventions:   Drug: optional ASA as comedication;   Drug: placebo to ASA;   Drug: placebo to optional ASA as comedication;   Drug: placebo to dabigatran etexilate;   Drug: ASA 100 mg;   Drug: dabigatran etexilate
Sponsor:   Boehringer Ingelheim
Recruiting - verified June 2016

Multicenter Study to Develop a Risk Model for Early Major Cardiovascular Events

Condition:   Acute Coronary Syndromes
Intervention:  
Sponsor:   Instituto Mexicano del Seguro Social
Recruiting - verified June 2016

Ticagrelor Versus Clopidogrel in Left Ventricular Remodeling After ST-segment Elevation Myocardial Infarction

Condition:   ST Segment Elevation Myocardial Infarction.
Interventions:   Drug: Ticagrelor;   Drug: Clopidogrel
Sponsors:   Gyeongsang National University Hospital;   Chinese PLA General Hospital;   Chungnam National University Hospital;   Pusan National University Yangsan Hospital;   National University Heart Centre, Singapore;   Ulsan University Hospital;   Kyungpook National University;   Samsung Changwon Hospital;   Kyunghee University Medical Center;   Chungbuk National University Hospital;   Chonnam National University Hospital;   Seoul National University Bundang Hospital
Recruiting - verified June 2016

Antiplatelet Therapy After Cardiac Arrest

Conditions:   Cardiac Arrest;   Postresuscitation Syndrome;   Myocardial Infarction (STEMI and NSTEMI)
Interventions:   Drug: Clopidogrel;   Drug: Ticagrelor
Sponsor:   University Medical Centre Ljubljana
Completed - verified June 2016

Arachidonic Acid-induced Platelet Aggregation Rate in Patients With Stable CAD Treated With Ticagrelor Monotherapy

Condition:   Coronary Heart Disease
Interventions:   Drug: ticagrelor;   Drug: Aspirin
Sponsor:   Yong Huo
Completed - verified June 2016

Non Invasive dP/dt to Detect an Acute Ischemic Myocardial Dysfunction in Emergency Department

Condition:   Acute Myocardial Ischemia
Intervention:  
Sponsor:   University of Monastir
Active, not recruiting - verified June 2016

COlchicine Improve EnDothElial Function in Non ST Elevation Myocardial Infarction Patients

Condition:   NSTEMI
Interventions:   Drug: Colchicine;   Drug: Placebo
Sponsors:   Tel-Aviv Sourasky Medical Center;   Tel Aviv Medical Center
Withdrawn - verified June 2016

HARMONEE - Japan-USA Harmonized Assessment by Randomized, Multi-Center Study of OrbusNEich's Combo StEnt

Conditions:   Coronary Arteriosclerosis;   Non ST Segment Elevation Acute Coronary Syndrome
Interventions:   Device: OrbusNeich Combo stent™;   Device: Everolimus Eluting Stent (EES)
Sponsors:   OrbusNeich;   OrbusNeich Medical K.K.;   Duke Clinical Research Institute
Active, not recruiting - verified June 2016

Use of Abbott High Sensitivity Troponin I Assay In Acute Coronary Syndromes

Conditions:   Acute Coronary Syndrome;   Myocardial Infarction;   Troponin
Intervention:  
Sponsors:   Minneapolis Medical Research Foundation;   Abbott Diagnostics Division;   Hennepin County Medical Center, Minneapolis
Active, not recruiting - verified June 2016

A Pharmacodynamic Study of a Personalized Strategy for P2Y12 Inhibition Versus Ticagrelor in Reducing Ischemic and Bleeding Risk

Conditions:   Acute Coronary Syndrome;   Percutaneous Coronary Intervention
Intervention:   Drug: Ticagrelor, Prasugrel, Clopidogrel
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research (CIHR)
Recruiting - verified June 2016

Acute Coronary Syndrome Genetic Study

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsors:   Peking University First Hospital;   Ministry of Science and Technology of the People´s Republic of China
Recruiting - verified June 2016

Effects of Ranolazine and Exercise on Daily Physical Activity Trial

Condition:   Chronic Stable Angina
Interventions:   Drug: Ranolazine;   Behavioral: Aerobic Exercise;   Drug: Placebo
Sponsors:   Duke University;   Gilead Sciences
Active, not recruiting - verified May 2016

Gadobutrol/Gadavist-enhanced Cardiac Magnetic Resonance Imaging (CMRI) to Detect Coronary Artery Disease (CAD)

Condition:   Coronary Artery Disease
Intervention:   Drug: Gadobutrol (Gadovist, BAY86-4875)
Sponsor:   Bayer
Active, not recruiting - verified June 2016

Gadobutrol / Gadavist-enhanced Cardiac Magnetic Resonance Imaging (CMRI) to Detect Coronary Artery Disease (CAD)

Condition:   Coronary Artery Disease
Intervention:   Drug: Gadobutrol (Gadovist, BAY86-4875)
Sponsor:   Bayer
Recruiting - verified June 2016

Genetic Risk and Health Coaching for Type 2 Diabetes and Coronary Heart Disease

Conditions:   Coronary Heart Disease, Susceptibility to, 5;   Prediabetic State
Interventions:   Behavioral: Health coaching;   Genetic: Genetic risk counseling;   Behavioral: Standard risk assessment
Sponsors:   Duke University;   David Grant U.S. Air Force Medical Center
Active, not recruiting - verified June 2016

A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure

Conditions:   Heart Failure;   Coronary Artery Disease
Interventions:   Drug: Rivaroxaban;   Drug: Placebo;   Other: Standard of care for heart failure and coronary artery disease
Sponsors:   Janssen Research & Development, LLC;   Bayer
Recruiting - verified June 2016

Impact of Perivascular Tissue on Endothelial Function in Coronary Artery Bypass Grafting

Condition:   Myocardial Ischemia
Interventions:   Procedure: no-touch;   Procedure: conventional
Sponsors:   Norwegian University of Science and Technology;   St. Olavs Hospital
Recruiting - verified June 2016

Cerebral Oximetry and Perioperative Outcome in Non-Cardiac Surgery

Conditions:   High Risk Non-cardiac Surgery;   Death;   Delirium;   Kidney Injury;   Myocardial Infarction;   Respiratory Failure;   Postoperative Infection
Intervention:   Other: Observational study
Sponsors:   University of Manitoba;   Canadian Anesthesia Research Foundation
Recruiting - verified June 2016

Study Comparing Ticagrelor With Aspirin for Prevention of Vascular Events in Patients Undergoing CABG

Conditions:   Coronary Artery Disease;   Stable Angina;   Acute Coronary Syndrome
Interventions:   Drug: Ticagrelor;   Drug: Aspirin;   Drug: Placebo - Ticagrelor;   Drug: Placebo - Aspirin
Sponsors:   Deutsches Herzzentrum Muenchen;   AstraZeneca
Recruiting - verified June 2016

Tailored Antiplatelet Therapy Following PCI

Conditions:   Coronary Artery Disease;   Acute Coronary Syndrome;   Stenosis
Interventions:   Drug: Clopidogrel;   Drug: Ticagrelor;   Genetic: Retrospective Genotype testing;   Genetic: Prospective Genotype testing
Sponsors:   Mayo Clinic;   Spartan Bioscience Inc.;   Applied Health Research Centre;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified June 2016

Comparison of Rubidium PET and SPECT With CZT Crystals for Detection of Myocardial Ischemia in Overweighed Patients and Women

Condition:   Myocardial Ischemia
Intervention:   Radiation: Rubidium PET
Sponsor:   Assistance Publique - Hôpitaux de Paris
Completed - verified June 2016

The Efficacy and Economics of Exercise Maintenance Post-Cardiac Rehabilitation

Condition:   Coronary Artery Disease
Intervention:   Behavioral: Exercise Facilitator Intervention
Sponsors:   Ottawa Heart Institute Research Corporation;   Heart and Stroke Foundation of Ontario
Recruiting - verified June 2016

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab;   Drug: Placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified June 2016

Phase III Trial of Dantonic® (T89) Capsule to Prevent and Treat Stable Angina

Condition:   Angina Pectoris
Interventions:   Drug: T89 high dose;   Drug: T89 Low dose;   Drug: Sanqi+Bingpian;   Drug: Placebo
Sponsor:   Tasly Pharmaceuticals, Inc.
Recruiting - verified November 2015

Tryptase and Coronary Heart Disease

Conditions:   Acute Coronary Syndrome With ST Elevation on Electrocardiogram;   Acute Coronary Syndrome Without ST Elevation on Electrocardiogram;   Noncritical Coronary Artery Disease With Coronary Stenosis <50%;   Aortic Aneurysms
Intervention:  
Sponsor:   Niguarda Hospital
Recruiting - verified June 2016

Renal Sympathetic Denervation for the Management of Chronic Hypertension

Condition:   Uncontrolled Hypertension
Intervention:   Device: Biosense Webster Celcius Thermacool catheter
Sponsors:   Vivek Reddy;   Biosense Webster, Inc.
Completed - verified June 2016

Stem Cell Injection to Treat Heart Damage During Open Heart Surgery

Conditions:   Heart Disease;   Ischemic Heart Disease;   Coronary Artery Disease;   Coronary Artery Disease (CAD)
Intervention:   Other: Cell Therapy
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   NIH Heart Center at Suburban Hospital
Suspended - verified June 2016

Reducing Radioisotope Dose: the Half-Dose CZT Study

Condition:   Coronary Artery Disease
Intervention:   Other: Half-dose isotope for NuclearStressTest
Sponsor:   The Methodist Hospital System
Recruiting - verified June 2016

The eSVS® Mesh Post-Marketing Trial

Conditions:   Coronary Artery Disease;   Myocardial Ischemia;   Coronary Disease;   Heart Diseases;   Cardiovascular Diseases;   Arteriosclerosis;   Arterial Occlusive Diseases;   Vascular Diseases
Intervention:   Device: eSVS Mesh
Sponsors:   Kips Bay Medical, Inc.;   University Hospital, Basel, Switzerland
Terminated - verified June 2016

Imaging Whole Coronary Artery With Intravascular Ultrasound (Ivus) And Imap For Plaque Tissue Composition In Patients With Acute Myocardial Infarction

Condition:   Acute Coronary Syndrome
Intervention:   Device: iMAP
Sponsors:   Federal University of São Paulo;   Boston Scientific Corporation
Completed - verified June 2016

The IRIS-Resolute Integrity (IRIS-Integrity)

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea;   Medtronic
Active, not recruiting - verified June 2016

Evaluation of Effectiveness and Safety of XIENCE PRIME Stent (IRIS-PRIME)

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea;   Abbott
Active, not recruiting - verified June 2016

Evaluation of Effectiveness and Safety of BIOMATRIX Stent (IRIS-BIOMATRIX)

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea;   Dio
Active, not recruiting - verified June 2016

Evaluation of Effectiveness and Safety of NOBORI Stent

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea;   Terumo Corporation
Active, not recruiting - verified June 2016

Evaluation of Effectiveness and Safety of PROMUS Element Stent (IRIS-ELEMENT )

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea;   Boston Scientific Corporation
Active, not recruiting - verified June 2016

Observational Study for Left Main Disease Treatment

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea
Recruiting - verified June 2016

Autologous Bone Marrow Derived Stem Cells for Acute Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Biological: MNC;   Biological: AC 133;   Biological: Control
Sponsor:   Royan Institute
Completed - verified July 2010

Integrated Dual Exercise and Lexiscan Positron Emission Tomography: IDEALPET

Condition:   Coronary Artery Disease
Interventions:   Drug: Exercise plus Regadenoson (Lexercise);   Drug: Regadenoson (Lexiscan)
Sponsor:   Brigham and Women's Hospital
Recruiting - verified June 2016

Cardiovascular Disease Study

Condition:   Spinal Cord Injury
Interventions:   Procedure: 2 hour Oral Glucose Tolerance Test;   Procedure: Fat Meal Test
Sponsors:   VA Office of Research and Development;   Kessler Foundation
Recruiting - verified June 2016

Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction

Condition:   Cardiovascular Disease
Intervention:   Procedure: Cardiac MRI
Sponsors:   Cedars-Sinai Medical Center;   National Heart, Lung, and Blood Institute (NHLBI);   University of Florida;   University of Pittsburgh
Active, not recruiting - verified June 2016

Evaluating a New Echocardiography Imaging Procedure for Evaluating Heart Function

Conditions:   Ischemia;   Myocardial Infarction;   Ischemic Heart Disease
Intervention:  
Sponsors:   Yale University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified June 2016

Measurement of Matrix Metalloproteinase Activation Post Myocardial Infarction

Condition:   Acute Myocardial Infarction
Intervention:  
Sponsor:   Yale University
Withdrawn - verified June 2016

A Study of RO4607381 in Patients With Coronary Heart Disease (CHD) or a CHD Risk Equivalent.

Condition:   Coronary Heart Disease
Interventions:   Drug: Placebo;   Drug: dalcetrapib
Sponsor:   Hoffmann-La Roche
Completed - verified June 2016

Technical Development of Cardiovascular Magnetic Resonance Imaging

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified June 2016

Trends in Trans-Fatty Acid Intake Between 1980 and 1997

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Heart Diseases
Intervention:  
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified June 2016