Coronary Artery Disease

Clinical Trial Finder

Many patients with coronary artery disease are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease

Conditions:   Coronary Arteriosclerosis;   Endothelial Function
Intervention:   Drug: Paracetamol
Sponsor:   University of Zurich
Completed

Essen Coronary Artery Disease Registry

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   University Hospital, Essen
Recruiting

Cost-effectiveness and Safety of the CADScorSystem in Patients With Symptoms Suggestive of Stable Coronary Artery Disease.

Condition:   Angina, Stable
Intervention:   Device: CADScor®System
Sponsors:   Bispebjerg Hospital;   Region Hovedstaden;   Larix A/S;   Acarix;   Kai Hansen Foundation;   Kai Houmann Nielsens Fond
Recruiting

AZD5718 Phase IIa Study to Evaluate Efficacy, Safety and Tolerability of Oral AZD5718 in Patients With Coronary Artery Disease (CAD).

Condition:   Coronary Artery Disease
Interventions:   Drug: AZD5718;   Drug: Placebo
Sponsor:   AstraZeneca
Recruiting

A Randomized Controlled Trial in Women With Coronary Artery Disease Investigating the Effects of Aerobic Interval Training Versus Moderate Intensity Continuous Exercise

Condition:   Coronary Artery Disease
Intervention:   Other: AIT Group
Sponsor:   University Health Network, Toronto
Completed

A Multicentre, Pilot Study to Evaluate the Safety and the Feasibility of Planning and Execution of Surgical Revascularization in Patients With Complex Coronary Artery Disease, Based Solely on MSCT Imaging Utilizing GE Healthcare Revolution CT and HeartFlow FFRCT.

Condition:   Multivessel Coronary Artery Disease
Intervention:   Radiation: Multi-sliced computed tomography (MSCT)
Sponsors:   ECRI bv;   GE Healthcare;   HeartFlow, Inc.
Withdrawn

Effects of Tai Chi Cardiac Rehabilitation Program on Safety and Effectiveness for Patients With Coronary Heart Disease

Condition:   Coronary Heart Disease
Interventions:   Behavioral: Control Group :conventional exercise rehabilitation;   Behavioral: Experimental Group :Tai Chi cardiac rehabilitation program
Sponsors:   Chinese PLA General Hospital;   Beijing Normal University
Recruiting

Safety and Potential Bioactivity of CLBS16 in Patients With Coronary Microvascular Dysfunction and Without Obstructive Coronary Artery Disease

Condition:   Coronary Microvascular Dysfunction
Intervention:   Biological: CLBS16
Sponsors:   Caladrius Biosciences, Inc.;   National Heart, Lung, and Blood Institute (NHLBI);   Cedars-Sinai Medical Center;   Mayo Clinic
Active, not recruiting

Effect of Antithrombotic Treatment in Patients With Both Coronary Heart Disease and Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Coronary Heart Disease
Intervention:  
Sponsor:   Henan Institute of Cardiovascular Epidemiology
Recruiting

Coronary Artery Geometry and the Severity of Coronary Atherosclerosis

Conditions:   Coronary Artery Disease;   Atherosclerosis;   Atherosclerotic Plaque;   Stable Angina
Intervention:   Diagnostic Test: CCTA
Sponsor:   Aristotle University Of Thessaloniki
Not yet recruiting

Comparison of the Severity of Coronary Atherosclerosis With Tissue Compliance in Patients Within First Degree Relatives

Condition:   Coronary Artery Disease With Myocardial Infarction
Intervention:   Diagnostic Test: there is not any intervention procedure
Sponsor:   TC Erciyes University
Not yet recruiting

Quantification of NLRP3 (rs4612666) and CARD8 Gene (rs2043211) in Generalized Chronic Periodontitis Subjects

Conditions:   Periodontal Diseases;   Coronary Artery Disease
Intervention:  
Sponsor:   Meenakshi Ammal Dental College and Hospital
Recruiting

Liraglutide Effects on Epicardial Fat Inflammatory Genes

Conditions:   Type2 Diabetes;   Coronary Artery Disease
Interventions:   Drug: Liraglutide Pen Injector [Victoza];   Drug: matching liraglutide-placebo pre-filled pens
Sponsor:   University of Miami
Recruiting

Investigating the Effects of Cardiac Rehabilitation eXercise Modalities on Physical and Mental Health Outcomes

Condition:   Coronary Artery Disease (CAD)
Interventions:   Behavioral: High Intensity Interval Training;   Behavioral: Moderate Intensity Continuous Exercise Training;   Behavioral: Nordic Walking
Sponsors:   Ottawa Heart Institute Research Corporation;   Ontario Ministry of Health and Long Term Care;   Heart and Stroke Foundation of Canada
Active, not recruiting

Prospective International Study of Coronary Subtraction Using 320 Detector Row CT (CorSub)

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Exercise as a Modulator of Immune Risk Factors for Ischemic Heart Disease

Condition:   Heart Diseases
Intervention:   Other: Exercise training
Sponsor:   East Tennessee State University
Completed

Simultaneous Assessment of FFR and SPECT

Condition:   Coronary Artery Disease
Intervention:   Radiation: SPECT imaging
Sponsors:   University of Pittsburgh;   Astellas Pharma US, Inc.
Recruiting

Impact of Chronic Kidney Disease on Clopidogrel Effects in Diabetes Mellitus

Conditions:   Chronic Kidney Disease (CKD);   Type 2 Diabetes Mellitus (T2DM);   Coronary Artery Disease (CAD)
Interventions:   Drug: Clopidogrel;   Drug: Clopidogrel active metabolite
Sponsor:   University of Florida
Recruiting

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

Condition:   Coronary Artery Disease
Interventions:   Other: Nitrous Oxide;   Other: No Nitrous Oxide
Sponsors:   Bayside Health;   National Health and Medical Research Council, Australia
Completed

Machine Learning in Quantitative Stress Echocardiography

Conditions:   Cardiovascular Diseases;   Ischaemic Heart Disease
Intervention:   Other: Analysis
Sponsors:   Hull University Teaching Hospitals NHS Trust;   Barts & The London NHS Trust;   Cardiff and Vale University Health Board
Recruiting

Implementation of CYP2C19 Genotyping to Guide Antiplatelet Therapy

Condition:   Coronary Artery Disease
Intervention:   Device: SpartanRX
Sponsors:   University of Florida;   National Institutes of Health (NIH);   National Human Genome Research Institute (NHGRI)
Active, not recruiting

The Elixir Bioadaptor vs. The Onyx Stent in De Novo Native Coronary Arteries

Condition:   Coronary Artery Disease
Intervention:   Device: stenting
Sponsor:   Elixir Medical Corporation
Not yet recruiting

Multislice Computed Tomography Assessment of PCSK9 Inhibition on Coronary Perfusion

Condition:   Coronary Artery Disease
Intervention:   Biological: Evolocumab
Sponsors:   ECRI bv;   Amgen;   GE Healthcare;   HeartFlow, Inc.
Withdrawn

Registry of Patients With a Bioabsorbable Magnesium Stent Implant MAGMARIS in Usual Clinical Practice

Condition:   Coronary Artery Disease
Intervention:   Device: Magmaris
Sponsor:   Spanish Society of Cardiology
Active, not recruiting

Coronary Flow Reserve (CFR) in Cardiovascular Risk Stratification

Conditions:   Ischemia, Myocardial;   Ischemic Heart Disease
Intervention:   Diagnostic Test: CZT SPECT acquisition
Sponsor:   Centre Hospitalier Régional d'Orléans
Recruiting

Nurses' Health Study (Cardiovascular Component)

Conditions:   Cardiovascular Diseases;   Diabetes Mellitus;   Coronary Disease;   Heart Diseases;   Cerebrovascular Accident;   Pulmonary Embolism;   Angina Pectoris;   Myocardial Infarction;   Menopause;   Postmenopause
Intervention:  
Sponsors:   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Personalized Vs. Standard Duration of Dual Antiplatelet Therapy and New-generation Polymer-Free vs- Biodegradable-Polymer DES

Conditions:   Coronary Artery Disease;   Acute Coronary Syndrome;   Chronic Coronary Syndrome;   Myocardial Infarction
Interventions:   Device: Percutaneous coronary intervention with implantation of amphilimus-eluting stents for coronary artery disease.;   Device: Percutaneous coronary intervention with implantation of everolimus-eluting stents for coronary artery disease.;   Drug: Personalized DAPT duration;   Drug: Standard DAPT duration
Sponsors:   Federico II University;   AdvicePharma Group
Recruiting

ROtational Atherectomy, Lithotripsy or LasER for the Treatment of CAlcified STEnosis

Condition:   Coronary Artery Disease
Intervention:   Device: Percutaneous coronary Intervention
Sponsor:   Hospital Universitario La Paz
Not yet recruiting

DynamX Sirolimus StudySirolimus Eluting Coronary Bioadaptor System

Condition:   Coronary Artery Disease
Intervention:   Device: DynamX Sirolimus-eluting Coronary Bioadaptor System
Sponsor:   Elixir Medical Corporation
Recruiting

RESOLUTE ONYX Post-Approval Study (Bifurcation Cohort)

Condition:   Coronary Artery Disease
Intervention:   Device: Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System
Sponsor:   Medtronic Vascular
Active, not recruiting

Evaluation of a Thin Strut Metallic Stent: DynamX Stent Clinical Study

Condition:   Coronary Artery Disease
Intervention:   Device: Percutaneous Coronary Intervention
Sponsor:   Elixir Medical Corporation
Active, not recruiting

RESOLUTE ONYX Post-Approval Study

Condition:   Coronary Artery Disease
Intervention:   Device: Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System
Sponsor:   Medtronic Vascular
Active, not recruiting

The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9 Level After Coronary Bypass Surgery

Condition:   Coronary Artery Disease
Interventions:   Behavioral: resistance training;   Behavioral: aerobic training
Sponsor:   National Cardiovascular Center Harapan Kita Hospital Indonesia
Completed

Post-Market Registry of the ACIST CPM System and Navvus Catheter in Clinical Practice

Condition:   Coronary Artery Disease
Intervention:   Device: Navvus Catheter FFR
Sponsor:   Acist Medical Systems
Completed

The CHORAL Flow Study

Conditions:   Coronary Artery Disease;   Atherosclerosis;   Hyperlipidemias
Interventions:   Biological: Evolocumab;   Drug: Placebo
Sponsor:   Imperial College London
Recruiting

The Sakakibara Health Integrative Profile of Atherosclerotic-Carcinogenesis Hypothesis (SHIP-AC)

Conditions:   Cancers;   Atheroscleroses, Coronary;   Atherosclerosis of Artery
Intervention:   Other: incidece of cancers
Sponsor:   Sakakibara Heart Institute
Completed

A Clinical Evaluation of Absorb™ Bioresorbable Vascular Scaffold (Absorb™ BVS) System in Chinese Population ~ ABSORB CHINA Randomized Controlled Trial (RCT)

Conditions:   Coronary Artery Disease;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Stenosis
Interventions:   Device: XIENCE V EECSS;   Device: Absorb BVS System
Sponsor:   Abbott Medical Devices
Completed

Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients

Conditions:   Frail Elderly;   Coronary Artery Disease
Interventions:   Procedure: Off-pump coronary-artery bypass grafting;   Procedure: On-pump coronary-artery bypass grafting
Sponsors:   University of Sao Paulo General Hospital;   Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina de São Paulo;   Hospital Alberto Urquiza Wanderley;   Hospital das Clínicas Samuel Libânio;   Hospital Samaritano Paulista;   Beneficência Portuguesa de São Paulo;   Hospital Samaritano Campinas;   Instituto Nacional de Cardiologia de Laranjeiras;   Pronto-Socorro Cardiológico Universitário de Pernambuco;   Mount Sinai Hospital, New York
Recruiting

Percutaneous Coronary Intervention Registry FRIBOURG

Conditions:   Coronary Artery Disease;   Percutaneous Coronary Intervention
Intervention:   Device: Percutaneous coronary intervention, stents
Sponsor:   University of Freiburg
Recruiting

CORonaRy Angiography and intErventions Via Distal vs Proximal aCcess

Conditions:   Coronary Angiography;   Coronary Artery Disease
Intervention:   Procedure: Use of radial artery for access for a coronary angiography or intervention
Sponsors:   Dr. med. Karsten Schenke;   Asklepios proresearch
Not yet recruiting

Study to Gain Insights in Treatment Patterns and Outcomes in Patients With Atherosclerosis Prescribed to Xarelto in Combination With Acetylsalicylic Acid

Condition:   Atherosclerosis
Interventions:   Drug: Rivaroxaban (BAY59-7939, Xarelto);   Drug: Acetylsalicylic acid
Sponsors:   Bayer;   Janssen, LP
Recruiting

Evaluating New Radiation Techniques for Cardiovascular Imaging

Condition:   Coronary Disease
Intervention:   Device: The Toshiba Aquilion ONE CT system
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Suspended

Myocardial Infarction With Non-Obstructive Coronary Arteries in the Greek Population

Conditions:   Acute Myocardial Infarction;   Non-Obstructive Coronary Atherosclerosis;   Ischemic Heart Disease;   Angina Pectoris;   Coronary Microvascular Disease
Interventions:   Other: MINOCA registry;   Diagnostic Test: CCTA Phenotypes
Sponsor:   AHEPA University Hospital
Not yet recruiting

Disrupt CAD IV With the Shockwave Coronary IVL System

Conditions:   Coronary Artery Disease;   Myocardial Infarction
Intervention:   Device: Lithotripsy
Sponsor:   Shockwave Medical, Inc.
Recruiting

Effect of Evolocumab on Coronary Endothelial Function

Conditions:   Human Immunodeficiency Virus;   Coronary Artery Disease
Intervention:   Drug: evolocumab
Sponsors:   Johns Hopkins University;   American Heart Association
Completed

ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study

Conditions:   Healthy Volunteers;   Atherosclerotic Heart Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting

Glycemic Control Using Mobile-based Intervention in Patients With Diabetes Undergoing Coronary Artery Bypass to Promote Self-management

Conditions:   Coronary Artery Disease;   Coronary Artery Bypass;   Diabetes Mellitus
Intervention:   Behavioral: Smartphone Application
Sponsors:   China National Center for Cardiovascular Diseases;   Chinese Academy of Medical Sciences, Fuwai Hospital
Recruiting

Post-Marketing Safety Study in ST-Segment Elevation Myocardial Infarction (STEMI) Participants Undergoing Primary Percutaneous Coronary Intervention (PCI) Procedure With VISIPAQUE® as the Contrast Medium

Conditions:   Coronary Artery Disease;   ST-segment Elevation Myocardial Infarction
Intervention:   Drug: Iodixanol
Sponsor:   GE Healthcare
Recruiting

Prospective Multicenter Registry On Radiation Dose Estimates Of Cardiac CT Angiography in Daily Practice in 2017 (PROTECTION VI)

Conditions:   Coronary Artery Disease;   Coronary Disease;   Myocardial Ischemia;   Arterial Occlusive Diseases;   Arteriosclerosis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Study to Develop a Tool to Estimate the Kidney Function in Databases Without Laboratory Data

Condition:   Renal Function
Intervention:   Other: No Intervention
Sponsor:   Bayer
Completed

Targeting Obesity to Optimize Health in Cardiac Rehab (TOPCARE)

Conditions:   Obesity;   Weight Loss;   CHD - Coronary Heart Disease
Interventions:   Other: Exercise;   Behavioral: Health Education;   Other: Exercise Compliance;   Dietary Supplement: Calorie-Restricted Diet;   Behavioral: Behavioral Modification;   Other: Weight-Loss Compliance;   Other: Dietary Counseling
Sponsors:   Wake Forest University Health Sciences;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Tailored Antiplatelet Therapy Following PCI

Conditions:   Coronary Artery Disease;   Acute Coronary Syndrome;   Stenosis
Interventions:   Drug: Clopidogrel;   Drug: Ticagrelor;   Genetic: Retrospective Genotype testing;   Genetic: Prospective Genotype testing;   Other: Smartphone
Sponsors:   Mayo Clinic;   Spartan Bioscience Inc.;   Applied Health Research Centre;   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation

PANDORA: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients

Conditions:   Delirium in Old Age;   Delirium;   Coronary Artery Disease
Interventions:   Drug: IV acetaminophen;   Other: Placebo
Sponsor:   Beth Israel Deaconess Medical Center
Not yet recruiting

PROMISE Substudy to Assess For Effective Dose of Radiation (PROMISE-SAFER) Specific Aim 3b

Conditions:   Chest Pain;   Coronary Artery Disease;   Angina
Intervention:  
Sponsors:   Kaiser Permanente;   Columbia University
Completed

Clinical Presentations Before AMI Onset and Coronary Atherosclerosis

Condition:   Acute Myocardial Infarction
Intervention:  
Sponsor:   Harbin Medical University
Completed

Effects of empagliFlozin on myocardIal metabOlic Rate of glucosE Estimated Through 18FDG PET (FIORE Study)

Conditions:   Type 2 Diabetes;   Cardiovascular Risk Factor
Interventions:   Drug: Empagliflozin 10 MG;   Drug: Glimepiride 2 mg
Sponsor:   University of Catanzaro
Recruiting

Cardiovascular Events in Chronic Obstructive Pulmonary Disease Patients Initiating Olodaterol or Other Long-acting beta2 Agonists

Condition:   Pulmonary Disease, Chronic Obstructive
Intervention:  
Sponsor:   Boehringer Ingelheim
Active, not recruiting

WAMIF : Young Women Presenting Acute Myocardial Infarction in France

Conditions:   Acute Myocardial Infarction;   Women Over 18 and Under 50 Years of Age
Intervention:   Other: Specific blood sample of women under 50 years with acute MI
Sponsors:   French Cardiology Society;   French Federation of Cardiology;   I.V.S. Institut des Vaisseaux et du Sang;   Biosensors Europe SA;   AstraZeneca;   Boston Scientific Corporation;   Abbott Medical Devices;   Terumo Corporation;   Daiichi Sankyo, Inc.;   Hexacath, France;   Biotronik SE & Co. KG
Recruiting

Insulin Resistance and Atherosclerosis in Women With Lupus

Conditions:   Systemic Lupus Erythematosus;   Insulin Resistance;   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Completed

Vascular Aging: The Link That Bridges Age to Atherosclerosis (The VALIDATE Study)

Conditions:   Atherosclerosis;   Cardiovascular Disease;   Vascular Diseases
Intervention:  
Sponsor:   National Institute on Aging (NIA)
Terminated

The Cardiovascular Multi-dimensional Observational Investigation of the Use of PCSK9 Inhibitors (cvMOBIUS)

Condition:   ASCVD
Intervention:  
Sponsors:   Amgen;   Duke Clinical Research Institute
Recruiting

Trimetazidine as an Adjunct to Enhance Clopidogrel Response.

Condition:   Platelet Dysfunction Due to Drugs
Intervention:   Drug: Trimetazidine
Sponsor:   The University of The West Indies
Completed

Development of a Prognostic Tool for the Stratification of Cardiovascular Risk in Patients With Ischemic Stroke

Conditions:   Stroke, Ischemic;   Cardiovascular Risk Factor;   Cardiovascular Diseases;   Cardiovascular Morbidity
Intervention:  
Sponsor:   University of Thessaly
Completed

A Genome-Wide Scan For Quantitative Trait Loci of Serum Bilirubin - A Framingham Study

Condition:   Genetics
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Virtual Therapy as a Method Supporting the Cardiac Rehabilitation

Conditions:   Cardiovascular Diseases;   Coronary Artery Disease;   Depressive Symptoms;   Mood Disorders;   Anxiety State;   Stress
Interventions:   Behavioral: Cardiac rehabilitation;   Device: Virtual therapeutic support;   Behavioral: Standard therapeutic support
Sponsors:   University School of Physical Education in Wroclaw;   Foundation for Senior Citizen Activation SIWY DYM
Completed

CT COMPARE: CT Coronary Angiography to Measure Plaque Reduction

Condition:   Cardiovascular Disease
Interventions:   Drug: Rosuvastatin;   Drug: Atorvastatin
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Apabetalone for Pulmonary Arterial Hypertension: a Pilot Study

Condition:   Pulmonary Arterial Hypertension
Intervention:   Drug: Apabetalone
Sponsors:   Steeve Provencher;   Resverlogix Corp
Recruiting

Genetic Factors in Atherosclerosis

Condition:   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Completed

Epidemiology: Oxidative Stress and Early Atherosclerosis

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Atherosclerosis;   Coronary Arteriosclerosis
Intervention:  
Sponsors:   University of Minnesota;   Northwestern University;   Kaiser Permanente;   University of Alabama at Birmingham
Active, not recruiting

The Effect of High-Intensity Interval Training on Glucose Variability and Atrial Fibrillation Symptoms

Conditions:   Atrial Fibrillation;   Type 2 Diabetes
Intervention:   Behavioral: High-intensity interval training + standard care
Sponsor:   Ottawa Heart Institute Research Corporation
Not yet recruiting

Effect of Probiotic Supplementation on Endothelial Function II

Condition:   Cardiovascular Disease
Interventions:   Dietary Supplement: Goodbelly first;   Dietary Supplement: observation first
Sponsor:   Medical College of Wisconsin
Recruiting

A New Hormone Replacement Paradigm: Physiologic Restoration Study

Conditions:   Menopause;   Perimenopausal Disorder;   Menopause Related Conditions
Intervention:   Biological: Compounded topical estradiol and compounded topical progesterone in a carrier cream
Sponsor:   Women's Hormone Network
Not yet recruiting

XIENCE 28 USA Study

Conditions:   Bleeding Disorder;   Ischemic Stroke;   Hemorrhagic Stroke;   Hematological Diseases;   Thrombocytopenia;   Coagulation Disorder;   Anemia;   Renal Insufficiency;   Coronary Artery Disease
Interventions:   Device: XIENCE;   Drug: DAPT (aspirin and/or P2Y12 receptor inhibitor)
Sponsor:   Abbott Medical Devices
Recruiting

Comparison of Two Exercise Training Modes on Left Myocardial Regional Function After Myocardial Infarction Evaluated by 2D Strain Ultrasound

Condition:   Ischemic Cardiomyopathy
Intervention:   Other: Intermittent retraining program.
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Not yet recruiting

A Study Based on Data From German Registries That Looks at Characteristics of People Who Take the Medicine Empagliflozin for Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Intervention:   Drug: Empagliflozin
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Patient-centered and Clinical Outcomes After Minimally Invasive Cardiothoracic Surgery

Conditions:   Cardiac Disease;   Surgery
Intervention:   Procedure: Minimally invasive cardiac surgery
Sponsor:   Jessa Hospital
Recruiting

Mechanism and Outcome of Acute Ischemic Stroke in Cancer Patients

Conditions:   Ischemic Stroke;   Cancer
Intervention:   Other: Risk factors
Sponsor:   Mansoura University Hospital
Completed

Effect of Exercise Intervention on Body Composition and Quality of Life in Post-bariatric Surgery Patients

Condition:   Exercise Training
Intervention:   Other: walking exercise
Sponsor:   Chang Gung Memorial Hospital
Not yet recruiting

Efficacy and Safety Of Alirocumab to Prevent Early Cardiac Allograft Vasculopathy in Recent Heart Transplant Recipients

Condition:   Cardiac Allograft Vasculopathy
Interventions:   Drug: Alirocumab;   Other: Placebo
Sponsors:   Institute for Clinical and Experimental Medicine;   St. Anne's University Hospital Brno, Czech Republic;   Centre of Cardiovascular and Transplantation Surgery, Czech Republic
Recruiting

American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)

Conditions:   Diabetes Mellitus;   Chronic Kidney Diseases;   Heart Diseases;   Cardiovascular Diseases
Intervention:  
Sponsors:   University of New Mexico;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)-Phoenix Epidemiology and Clinical Research;   Zuni Pueblo;   Urban Albuquerque Area American Indians seen at First Nations Hospital
Not yet recruiting

Study of Abnormalities of the Nervous System in the Occurrence of Intradialytic Arterial Hypotension

Condition:   Hemodialysis Complication
Intervention:   Diagnostic Test: Cutaneous conductance to chlorine by SUDOSCAN
Sponsor:   Groupe Hospitalier Paris Saint Joseph
Recruiting

Effect of LOW-molecular-weight Heparin in Reducing Radial Artery Occlusion Rate After Transradial Coronary Catheterization

Condition:   Arterial Occlusion
Intervention:   Drug: low molecular weight heparin
Sponsor:   AHEPA University Hospital
Recruiting

Aortic Calcification and Central Blood Pressure in Patients With Chronic Kidney Disease

Conditions:   Arterial Calcification;   Kidney Diseases;   Coronary Artery Disease;   Aortic Calcification;   Stroke;   Vascular Diseases;   Vascular Calcification
Intervention:  
Sponsor:   Central Jutland Regional Hospital
Recruiting

Post-authorization Safety Study on the Long Term Safety of Sonidegib in Patients With Locally Advanced Cell Carcinoma

Condition:   Basal Cell Carcinoma
Intervention:   Drug: sonidegib
Sponsor:   Sun Pharmaceutical Industries Limited
Recruiting

Systemic, Pancoronary and Local Coronary Vulnerability

Conditions:   Coronary Stenosis;   Acute Coronary Syndrome;   Acute Myocardial Infarction;   Atheromatous Plaques;   Atheroscleroses, Coronary;   Non-ST Elevation Myocardial Infarction (nSTEMI)
Interventions:   Diagnostic Test: Cardiac imaging tests;   Diagnostic Test: Venous blood sample collection
Sponsors:   Cardio Med Medical Center;   University of Targu Mures, Romania;   University Hospital of Targu Mures, Romania
Recruiting

Technical Development of Cardiovascular Magnetic Resonance Imaging

Conditions:   Cardiomyopathy;   Congenital Heart Disease;   Cardiovascular Disease;   Cardiac Magnetic Resonance Imaging;   Acute Myocardial Infarction
Intervention:   Device: Siemens MRI scanner
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Suspended

The Role of Concomitant Diseases in Postoperative Complications Risk Stratification.

Conditions:   Coronary Heart Disease;   Anemia;   Bronchial Asthma;   Stroke;   Epilepsy;   Parkinson's Disease;   Heart Rhythm Disorders;   Alzheimer's Disease;   Neuromuscular Diseases;   Diabetes;   Chronic Heart Failure;   Chronic Obstructive Pulmonary Disease;   Chronic Kidney Diseases
Intervention:  
Sponsors:   Russian Federation of Anesthesiologists and Reanimatologists;   Kuban State Medical University
Recruiting

MUscle Side-Effects of Atorvastatin in Coronary Patients

Condition:   Statin Adverse Reaction
Interventions:   Drug: Atorvastatin 40mg;   Drug: Placebo Oral Tablet
Sponsors:   Vestre Viken Hospital Trust;   The Hospital of Vestfold;   Oslo University Hospital;   University of Oslo
Recruiting

Efficacy of Medical Therapy in Women and Men With Angina and Myocardial Bridging

Condition:   Myocardial Bridging
Interventions:   Drug: Nebivolol;   Drug: Diltiazem;   Other: Placebo
Sponsor:   Stanford University
Not yet recruiting

Frailty Assessment in Cardiac Surgery

Condition:   Frailty
Intervention:  
Sponsors:   Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital;   Turkish Society of Cardiovascular Surgery
Not yet recruiting

Anglo-Scandinavian Cardiac Outcomes Trial: Post Trial Follow-Up Study

Conditions:   Hypertension;   Diabetes;   Death From Cardiovascular Disease;   Myocardial Infarction;   Stroke
Intervention:  
Sponsors:   Imperial College London;   Pfizer
Completed

Non-Invasive Assessment of Atherosclerosis in Patients With CGD and Other Disorders of the Immune System

Conditions:   Atherosclerosis;   Chronic Granulomatous Disease (CGD)
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Active, not recruiting

COMBinAtion Therapy in Myocardial Infarction: The COMBAT-MI Trial

Condition:   ST Elevation Acute Myocardial Infarction
Interventions:   Drug: Exenatide;   Other: Remote Ischemic Conditioning (RIC);   Drug: Placebo
Sponsor:   Hospital Universitari Vall d'Hebron Research Institute
Active, not recruiting

Evaluation of Physiological Reactions in Virtual Reality

Conditions:   Pulmonary Disease;   Cardiac Disease
Intervention:   Diagnostic Test: stimulation in virtual reality
Sponsors:   The Opole University of Technology;   IRCCS San Camillo, Venezia, Italy
Recruiting

Perioperative Anticoagulant Use for Surgery Evaluation Emergency Registry

Conditions:   Atrial Fibrillation;   Venous Thromboembolism;   Arterial Vascular Disease
Intervention:  
Sponsors:   McMaster University;   Hamilton Health Sciences Corporation;   St. Joseph's Healthcare Hamilton
Recruiting

SINGaporean Program Performed With an eXPANsion Medical Device (SingXpand)

Condition:   Heart Attack
Intervention:   Combination Product: Protheracytes
Sponsor:   CellProthera
Active, not recruiting

Perioperative Anticoagulant Use for Surgery Evaluation Study Part 2 Pilot

Condition:   Atrial Fibrillation
Interventions:   Other: PAUSE Perioperative DOAC Management;   Other: ASRA Perioperative DOAC Management
Sponsors:   McMaster University;   Hamilton Health Sciences Corporation;   St. Joseph's Healthcare Hamilton
Not yet recruiting

ACS Registry - A Non-interventional Study to Estimate the Rates of Outcomes in ACS Patients in Moscow

Conditions:   Heart Attack;   Stroke;   Cardiovascular Death
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Long-Term Follow-Up and Management Patterns of Patients With Acute Coronary Syndrome in Middle East and Africa

Condition:   Acute Coronary Syndrom
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Active, not recruiting

The OPTIMAL Randomized Controlled Trial

Condition:   Left Main Coronary Artery Stenosis
Interventions:   Device: IVUS guided Percutaneous Coronary Intervention;   Device: QCA guided Percutaneous Coronary Intervention
Sponsors:   ECRI bv;   Philips Healthcare;   Boston Scientific Corporation
Not yet recruiting

Supplemental Study to Evaluate the Safety and Effectiveness of the NovaCross™ Micro-catheter

Condition:   Coronary Occlusion
Intervention:   Device: NovaCross™ Chronic Total Occlusion micro-catheter
Sponsor:   Nitiloop Ltd.
Completed

Heart Failure-USB: Prediction and Progression

Conditions:   Acute Heart Failure;   Acute Coronary Syndrome;   Heart Failure
Interventions:   Other: medical chart review;   Other: data generated by direct IT export
Sponsor:   University Hospital, Basel, Switzerland
Recruiting

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Active, not recruiting

Culotte Versus DK-CRUSH Technique in Non-left Main Coronary Bifurcation Lesions

Conditions:   Coronary Stenosis;   Stent Stenosis
Intervention:   Procedure: Stenting
Sponsor:   University Heart Center Freiburg - Bad Krozingen
Not yet recruiting

OPIOID-FREE ANESTHESIA FOR OPEN CARDIAC SURGERY: A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL

Conditions:   Opioid Use;   Heart; Surgery, Heart, Functional Disturbance as Result;   Anesthesia
Interventions:   Drug: Opioid Anesthetics;   Drug: Non Opioid Analgesics
Sponsors:   Benaroya Research Institute;   Virginia Mason Hospital/Medical Center
Not yet recruiting

Study of Clinical Features and Genetics of Hyperimmunoglobulin E Recurrent Infection

Conditions:   Coronary Aneurysm;   Dermatitis, Atopic;   Immune System Diseases;   STAT3 Transcription Factor;   Job Syndrome
Intervention:  
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Albert Einstein College of Medicine
Recruiting

NAN-101 in Patients With Class III Heart Failure

Conditions:   Congestive Heart Failure;   Heart Failure;   Heart Disease, Ischemic;   Cardiovascular Diseases;   Heart Failure, Systolic;   Heart Failure,Congestive;   Heart Arrhythmia;   Heart Failure, Diastolic;   Heart; Complications
Intervention:   Biological: 3 x 10e13vg NAN-101
Sponsor:   Asklepios Biopharmaceutical, Inc.
Recruiting

Registry Study on Drug Therapy and Clinical Outcomes in Patients With Acute Coronary Syndrome

Conditions:   Drug Therapy;   Acute Coronary Syndrome
Intervention:  
Sponsor:   Beijing Anzhen Hospital
Not yet recruiting

Low Dose of Hydrocortisone and Fludrocortisone in Adult Cardiogenic Shock.

Condition:   Cardiogenic Shock
Interventions:   Combination Product: Hydrocortisone + Flucortac;   Other: Placebo
Sponsor:   CMC Ambroise Paré
Recruiting

Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Biological: Apolipoprotein A-I [human] (apoA-I);   Other: Placebo
Sponsor:   CSL Behring
Recruiting

ADHerence of ticagrelOr in Real World Patients With aCute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Intervention:   Drug: Ticagrelor
Sponsor:   Fondazione per la Ricerca Ospedale Maggiore
Active, not recruiting

The Safety and Efficacy Of Rivaroxaban and Ticagrelor for Patients With Atrial Fibrillation After Percutaneous Coronary Intervention

Conditions:   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Ticagrelor;   Drug: Rivaroxaban
Sponsor:   Ottawa Heart Institute Research Corporation
Recruiting

Extended Care in High-Risk Surgical Patient (EXCARE) Pathway in High-risk Surgical Population

Conditions:   Postoperative Complications;   Patient Care Team
Interventions:   Behavioral: Postoperative Monitoring;   Diagnostic Test: High-sensitivity cardiac troponin testing
Sponsor:   Hospital de Clinicas de Porto Alegre
Recruiting

A Placebo-controlled Trial of Percutaneous Coronary Intervention for the Relief of Stable Angina

Condition:   Stable Angina
Intervention:   Procedure: Percutaneous coronary intervention
Sponsors:   Imperial College London;   Basildon and Thurrock Hospitals NHS FoundationTrust
Recruiting

Cardiac Magnetic Resonance Imaging Strategy for the Management of Patients With Acute Chest Pain and Detectable to Elevated Troponin

Conditions:   Acute Coronary Syndrome;   Chest Pain
Interventions:   Procedure: Cardiac MRI;   Other: ACC/AHA Guideline adherent care
Sponsors:   Wake Forest University Health Sciences;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Medical-economic Evaluation Comparing Intensive Outpatient Monitoring of Neuro-cardiovascular Diseases by Nurses, Doctors and Hospital and Private-sector Pharmacists, Compared to Usual Monitoring.

Conditions:   Cerebrovascular Accidents;   Myocardial Infarction
Interventions:   Other: Usual follow-up;   Other: Intensive follow-up
Sponsor:   Centre Hospitalier Universitaire Dijon
Not yet recruiting

Bivalirudin in Late PCI for Oatients With STEMI

Condition:   STEMI - ST Elevation Myocardial Infarction
Interventions:   Drug: Bivalirudin;   Drug: Heparin
Sponsor:   Second Xiangya Hospital of Central South University
Not yet recruiting

Assessment of ECMO in Acute Myocardial Infarction Cardiogenic Shock

Conditions:   Acute Myocardial Infarction;   Cardiogenic Shock
Intervention:   Device: VA-ECMO
Sponsor:   Assistance Publique - Hôpitaux de Paris
Not yet recruiting

Physical Activity Intervention in ELderly Patients With Myocardial INfarction

Conditions:   Myocardial Infarction;   Aging
Interventions:   Other: Health Education;   Other: Exercise Intervention
Sponsors:   University Hospital of Ferrara;   Azienda Usl di Bologna
Not yet recruiting

Comparison of Radial and Ulnar Artery Intervention in Patients With ST Elevated Myocardial Infarction

Condition:   ST Elevated Myocardial Infarction
Intervention:   Procedure: primary percutaneous coronary intervention
Sponsors:   Sakarya University;   Cosansu, Kahraman, M.D.
Recruiting

Pericardial Matrix With Mesenchymal Stem Cells for the Treatment of Patients With Infarcted Myocardial Tissue

Condition:   Myocardial Infarction
Interventions:   Combination Product: PeriCord: Expanded and cryopreserved allogeneic umbilical cord Wharton´s jelly-derived adult mesenchymal stem cells colonized on human pericardial matrix.;   Procedure: Surgery by sternotomy
Sponsors:   Fundació Institut Germans Trias i Pujol;   Germans Trias i Pujol Hospital
Recruiting

Treatment of Post-STEMI Left Ventricular Thrombus With Optimized Anticoagulant

Conditions:   ST Segment Elevation Myocardial Infarction;   Left Ventricular Thrombus
Interventions:   Drug: Rivaroxaban;   Drug: Vitamin K Antagonist
Sponsor:   RenJi Hospital
Not yet recruiting

Effects of Dried Bilberry, Liquid Oats, or Their Combination After AMI

Condition:   Myocardial Infarction
Interventions:   Dietary Supplement: Bilberry;   Dietary Supplement: Placebo;   Dietary Supplement: Liquid oats;   Dietary Supplement: Combination bilberry/oats
Sponsors:   Ole Frobert, MD, PhD;   Region Västmanland;   Region Skane;   Chalmers University of Technology;   Västerbotten County Council
Not yet recruiting

Brilinta Clinical Experience Investigation

Condition:   Acute Coronary Syndrome, Old Myocardial Infarction
Intervention:  
Sponsor:   AstraZeneca
Recruiting

Milrinone Versus Dobutamine in Critically Ill Patients

Conditions:   Low Cardiac Output Syndrome;   Cardiogenic Shock;   Acute Coronary Syndrome;   Pulmonary Edema
Interventions:   Drug: Milrinone;   Drug: Dobutamine
Sponsor:   Ottawa Heart Institute Research Corporation
Recruiting

Cohort Study - SBRT for VT Radioablation

Conditions:   Ventricular Tachycardia;   Myocardial Infarction;   Heart Disease Structural Disorder
Intervention:   Radiation: Stereotactic Body Radiotherapy (SBRT) ablation of VT
Sponsor:   John Sapp
Not yet recruiting

PPI's and SSRI's Therapy for the Management of NCCP

Condition:   Chest Pain Rule Out Myocardial Infarction
Intervention:   Drug: Citalopram
Sponsor:   Evangelismos Hospital
Terminated

High-Intensity Interval Training Early After Left Ventricular Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Other: HIIT;   Other: MICE
Sponsor:   University Hospital Inselspital, Berne
Recruiting

Vorapaxar in Patients With Prior Myocardial Infarction Treated With Prasugrel and Ticagrelor

Condition:   Myocardial Infarction
Interventions:   Drug: Prasugrel;   Drug: Vorapaxar;   Drug: Aspirin;   Drug: Ticagrelor
Sponsors:   University of Florida;   Merck Sharp & Dohme Corp.
Active, not recruiting

BIO monitorinG in Patients With Preserved Left ventricUlar Function AfteR Diagnosed Myocardial Infarction

Conditions:   Myocardial Infarction;   Myocardial Infarction, Acute;   Myocardial Infarction Old
Intervention:   Device: BioMonitor
Sponsor:   Biotronik SE & Co. KG
Recruiting

A Phase 2 Trial of AMI MultiStem® Therapy in Subjects With Non-ST Elevation Acute Myocardial Infarction

Conditions:   Heart Attack;   NSTEMI
Interventions:   Biological: AMI MultiStem cells;   Other: Sham
Sponsors:   Athersys, Inc;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

A Retrospective Study of CT (Computerized Tomography) for Late Window Large Vessel Occlusion (LVO)

Condition:   Stroke, Cardiovascular
Intervention:  
Sponsors:   Boston Medical Center;   Medtronic
Recruiting

Flublok v. Standard Dose Vaccine Effectiveness Among Kaiser Permanente Northern California Adults 18-64 Years

Conditions:   Influenza;   Pneumonia;   Lower Respiratory Tract Infection;   Acute Myocardial Infarction;   Congestive Heart Failure;   Stroke
Interventions:   Biological: Flublok Quadrivalent;   Biological: Standard Dose Inactivated Influenza Vaccine (SD-IIV)
Sponsors:   Kaiser Permanente;   Sanofi Pasteur, a Sanofi Company
Recruiting

PRediction of Acute Coronary Syndrome in Acute Ischemic StrokE

Conditions:   Stroke, Ischemic;   Acute Coronary Syndrome
Intervention:   Diagnostic Test: Coronary angiography
Sponsors:   Charite University, Berlin, Germany;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK);   German Center for Neurodegenerative Diseases (DZNE)
Recruiting

Impact of EMpagliflozin on Cardiac Function and Biomarkers of Heart Failure in Patients With Acute MYocardial Infarction

Condition:   Acute Myocardial Infarction
Interventions:   Drug: Empagliflozin 10 mg;   Drug: Placebo Oral Tablet
Sponsors:   Medical University of Graz;   United Arab Emirates University;   Medical University of Vienna;   Landeskrankenhaus Feldkirch;   Paracelsus Medical University;   Hospital Rudolfstiftung;   Klinikum Klagenfurt am Wörthersee;   Barmherzige Brüder Eisenstadt;   Kardinal Schwarzenberg Klinikum Schwarzach St. Veit;   Johannes Kepler University of Linz;   Landesklinikum Sankt Polten;   Landeskrankenhaus II Graz West
Recruiting

Mechanisms of Action of Acetaminophen

Conditions:   Myocardial Infarction;   Arthritis
Interventions:   Drug: Aspirin First;   Drug: Aspirin Last;   Drug: Acetaminophen 1000 mg/d;   Drug: Acetaminophen 4000 mg/d;   Drug: Ibuprofen 800 mg/d
Sponsor:   University of Pennsylvania
Completed

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Warfarin;   Drug: Antiplatelet drugs
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxoban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Active, not recruiting

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Germany)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

Remote Ischaemic Preconditioning in Transplantation (RIPTRANS)

Condition:   Transplant Dysfunction
Interventions:   Procedure: RIPC;   Procedure: Sham-RIPC
Sponsors:   Helsinki University Central Hospital;   Finska Läkaresällskapet (funding)
Recruiting