Coronary Artery Disease

Clinical Trial Finder

Many patients with coronary artery disease are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Progression of Coronary Atherosclerosis in Asymptomatic Diabetic Subjects

Conditions:   Type 2 Diabetes;   Coronary Artery Disease
Intervention:  
Sponsors:   British Cardiac Research Trust;   Royal Free Hospital NHS Foundation Trust;   North West London Hospitals NHS Trust;   Barnet and Chase Farm Hospitals NHS Trust;   Diabetes and Obesity Research Network;   Lund University;   Health Diagnostic Laboratory, Inc.
Recruiting - verified April 2014

DIAMOND - Dual Antiplatelet Therapy to Reduce Myocardial Injury

Condition:   Coronary Artery Disease
Interventions:   Drug: Ticagrelor;   Drug: Placebo
Sponsors:   University of Edinburgh;   AstraZeneca
Not yet recruiting - verified April 2014

EARly Prevention of aTHeroma Progression

Condition:   Coronary Arteriosclerosis
Interventions:   Behavioral: Standard Therapy;   Drug: Rosuvastatin
Sponsors:   Asan Medical Center;   CHEOL WHAN LEE, M.D., Ph.D;   AstraZeneca
Not yet recruiting - verified April 2014

Evaluation of a New Design of Crowns in the Posterior Teeth

Conditions:   Broken Down Molars;   IPS-emmax Crowns
Intervention:   Other: IPS.emmax endocrown
Sponsor:   Damascus University
Not yet recruiting - verified March 2014

Motivational Interviewing and Medication Review in Coronary Heart Disease

Condition:   Coronary Heart Disease
Interventions:   Behavioral: Standard Treatment;   Behavioral: MI and Medication review
Sponsors:   Linneaus University;   Göran Petersson;   The Kamprad Family Foundation for Entrepreneurship, Research and Charity
Recruiting - verified April 2014

The ImPact of Trimetazidine on MicrOcirculation After Stenting for Stable Coronary Artery Disease

Conditions:   Coronary Artery Disease;   Microcirculation;   Vascular Resistance
Intervention:   Drug: trimetazidine
Sponsor:   Clinical Hospital Center Zemun
Recruiting - verified April 2014

Aerobic Exercise on Ventilatory Efficiency in CAD Patients

Conditions:   Coronary Artery Disease;   Exercise Addiction;   Complication, Cardio-respiratory
Intervention:   Other: Aerobic exercise training
Sponsor:   Hospital TotalCor
Completed - verified April 2014

Improving Adherence to Medication After Coronary Artery Bypass Surgery (CABG) in Older Adults

Condition:   Coronary Artery Bypass Grafting (CABG) Surgery
Interventions:   Behavioral: Motivational Interviewing (MI;   Behavioral: volitional intervention;   Behavioral: Routine discharge counseling
Sponsor:   Qazvin University Of Medical Sciences
Recruiting - verified April 2014

Effects of Beta-blockade on Cardiopulmonary Exercise Testing

Condition:   Abdominal Aortic Aneurysm Patients Under Surveillance
Intervention:   Drug: Bisoprolol
Sponsors:   Aintree University Hospitals NHS Foundation Trust;   Michelle Mossa
Completed - verified April 2014

Weight Loss as Treatment in Heart Disease

Condition:   Heart Failure
Intervention:   Behavioral: Dietetic group sessions
Sponsors:   University of Copenhagen;   University Hospital, Gentofte, Copenhagen
Completed - verified April 2014

BioMime Vs. Xience Randomised Control Clinical Study

Condition:   Coronary Artery Disease
Interventions:   Device: Sirolimus Eluting Coronary Stent;   Device: Everolimus-eluting Coronary stent
Sponsor:   Meril Life Sciences Pvt. Ltd.
Not yet recruiting - verified April 2014

A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease

Conditions:   Coronary Disease;   Coronary Stenosis
Interventions:   Procedure: FFR guided PCI;   Procedure: CABG
Sponsors:   Stanford University;   Cardiovascular Center Aalst, Belgium;   Catharina Hospital Eindhoven;   Golden Jubilee National Hospital;   University of California, Irvine;   Medtronic;   St. Jude Medical;   Genae
Not yet recruiting - verified April 2014

A Comparison of the Effects of Ketamine and Remifentanil on Serum Cystatin-c Levels in CABG Surgery

Condition:   Coronary Artery Disease
Interventions:   Drug: remifentanil;   Drug: Ketamine
Sponsor:   Turkiye Yuksek Ihtisas Education and Research Hospital
Completed - verified April 2014

Comprehensive Lifestyle Modification for Patients With Hypertension and Metabolic Syndrome: a Multicenter Randomized Controlled Trial

Conditions:   Hypertension;   Metabolic Syndrome
Interventions:   Behavioral: Comprehensive Lifestyle Modification;   Behavioral: DASH
Sponsors:   Universität Duisburg-Essen;   Kliniken Essen-Mitte;   Immanuel Hospital Berlin, Berlin, Germany;   Charité University Medical Center, Berlin, Germany;   University of Witten/Herdecke
Recruiting - verified April 2014

Safety and Efficacy of CMX-2043 for Protection of the Heart and Kidneys in Subjects Undergoing Coronary Angiography

Conditions:   Non STEMI;   Unstable Angina
Intervention:   Drug: CXM-2043
Sponsor:   Ischemix, LLC
Not yet recruiting - verified April 2014

PATient Navigator to rEduce Readmissions

Conditions:   Chronic Obstructive Pulmonary Disease;   Heart Failure;   Sickle Cell Disease;   Myocardial Infarction;   Pneumonia;   Vascular Procedures
Interventions:   Behavioral: Hospital usual care;   Behavioral: Patient Navigator;   Behavioral: Peer-led telephone support line
Sponsors:   University of Illinois at Chicago;   Patient-Centered Outcomes Research Institute (PCORI);   University of Illinois at Urbana-Champaign;   Society of Hospital Medicine;   COPD Foundation;   University of Kentucky;   Mended Hearts;   American Heart Association;   Sickle Cell Disease Association of Illinois;   AcademyHealth;   The National Association of Social Workers Foundation;   Respiratory Health Association of Metropolitan Chicago;   University of Illinois Sickle Cell Patient Council;   National Jewish Health;   Olmsted Medical Center;   Baystate Medical Center;   Department of Veterans Affairs
Not yet recruiting - verified April 2014

A Phase 2b Study of CSL112 in Subjects With Acute Myocardial Infarction.

Condition:   Acute Myocardial Infarction
Interventions:   Biological: CSL112;   Biological: Placebo
Sponsor:   CSL Behring
Not yet recruiting - verified April 2014

Early In-hospital Initiation of Pharmacotherapy for Smoking Cessation, Patients After ACS

Conditions:   Acute Coronary Syndrome;   Smoking Cessation
Interventions:   Drug: Varenicline;   Drug: placebo
Sponsors:   Sheba Medical Center;   Hadassah Medical Organization;   Barzilai Medical Center
Not yet recruiting - verified April 2014

Correlation Between Reticulated Platelets and Major Adverse Cardiac and Cerebrovascular Events After Noncardiac Surgery

Conditions:   Cardiac Death;   Congestive Heart Failure;   Angina Pectoris;   Stroke;   Pulmonary Embolism;   Deep Vein Thrombosis
Intervention:  
Sponsor:   Technische Universität München
Recruiting - verified April 2014

Computed Tomography and Biomarker Analysis in Diagnosing Coronary Artery Disease in Asymptomatic Patients Who Have Undergone Stem Cell Transplant

Conditions:   Cancer Survivor;   Diabetes Mellitus;   Hypertension
Interventions:   Procedure: computed tomography;   Other: cytology specimen collection procedure;   Other: laboratory biomarker analysis;   Other: questionnaire administration
Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI)
Recruiting - verified April 2014

Post-Market Registry of the ACIST CPM System and Navvus Catheter in Clinical Practice

Condition:   Coronary Artery Disease
Intervention:   Device: Navvus Catheter FFR
Sponsor:   Acist Medical Systems
Recruiting - verified April 2014

BIOFLOW III Satellite-ELADIS

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   C.E.M. Biotronik, S.A.
Recruiting - verified February 2014

Omega-3 for Depression and Other Cardiac Risk Factors - 2

Condition:   Depression
Intervention:   Drug: Omega-3 supplement
Sponsors:   Washington University School of Medicine;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 2014

A Randomized Trial of Intracoronary Reopro to Improve Coronary Microvascular Function

Conditions:   Myocardial Infarction;   Coronary Artery Disease
Intervention:   Drug: Abciximab
Sponsor:   University of Melbourne
Active, not recruiting - verified April 2014

Physical Activity Daily - An Internet-Based Walking Program for Patients With Peripheral Arterial Disease

Condition:   Peripheral Arterial Disease
Interventions:   Behavioral: Supervised PAD rehab;   Behavioral: Internet-based walking program
Sponsors:   University of Michigan;   National Institute on Aging (NIA)
Not yet recruiting - verified April 2014

EYESHOT (EmploYEd Antithrombotic Therapies in Patients With Acute Coronary Syndromes HOspitalized in iTalian Coronary Care Units)

Condition:   Acute Coronary Syndromes
Intervention:  
Sponsors:   Heart Care Foundation;   Centro Servizi ANMCO S.r.l.;   AstraZeneca
Completed - verified March 2014

MAGNetic QRS-Fragmentation in Patients With Myocardial InfarcTion and Moderately RedUceD Ejection Fraction

Condition:   Acute Myocardial Infarction
Intervention:  
Sponsors:   Medtronic Bakken Research Center;   Medtronic;   Medtronic Clinical Research Institute
Terminated - verified April 2014

Artifact-Free High-Resolution Myocardial Perfusion MRI in Subjects With Abnormal Nuclear Myocardial Perfusion Studies

Conditions:   Coronary Artery Disease;   CAD
Interventions:   Drug: regadenoson;   Drug: Optimark®;   Device: Myocardial perfusion MRI
Sponsors:   Cedars-Sinai Medical Center;   Daniel S. Berman;   Astellas Pharma US, Inc.
Recruiting - verified April 2014

In-hospital and Long-term Outcomes for Percutaneous Chronic Total Coronary Occlusion Revascularization in a High-volume, Multi-operator Program

Condition:   Ischemic Heart Disease
Intervention:  
Sponsor:   Piedmont Healthcare
Recruiting - verified April 2014

BIOFLOW III Asia Registry

Conditions:   Coronary Artery Disease;   Myocardial Ischemia;   Diabetes Mellitus Type 1 or 2
Intervention:  
Sponsor:   BIOTRONIK Asia Pacific Pte Ltd
Recruiting - verified February 2014

ABSORB STEMI: the TROFI II Study

Condition:   Acute ST Segment Elevation Myocardial Infarction
Intervention:   Device: Percutaneous Coronary Intervention
Sponsors:   ECRI bv;   Abbott Vascular;   Terumo Europe N.V.
Recruiting - verified April 2014

Correlation Between Coronary and Carotid Atherosclerotic Disease and Links With Clinical Outcomes

Condition:   Vascular Disease
Intervention:  
Sponsor:   Montreal Heart Institute
Recruiting - verified April 2014

BIOFLOW-III Israel Satellite Registry

Conditions:   Coronary Artery Disease;   Myocardial Ischemia;   Diabetes Mellitus Type 1 or 2
Intervention:  
Sponsor:   BIOTRONIK Israel
Recruiting - verified July 2013

BIOFLOW-III Hungary Satellite Registry

Conditions:   Coronary Artery Disease;   Myocardial Ischemia
Intervention:  
Sponsor:   Biotronik Hungária Kft.
Recruiting - verified July 2013

Interleukin-1 Blockade With Canakinumab to Improve Exercise Capacity in Patients With Chronic Systolic Heart Failure and Elevated Hs-CRP

Conditions:   Prior Acute Myocardial Infarction;   Evidence of Systemic Inflammation (C Reactive Protein Plasma >2 mg/l);   Reduced Left Ventricle Ejection Fraction (<50%);   Symptoms of Heart Failure (NYHA Class II-III)
Interventions:   Other: Cardiopulmonary exercise test;   Other: Echocardiogram
Sponsors:   Virginia Commonwealth University;   Novartis Pharmaceuticals
Active, not recruiting - verified April 2014

Walnut Consumption, Endothelial Function, and Biomarkers

Conditions:   Coronary Heart Disease;   Type 2 Diabetes
Intervention:   Other: Once ounce per day of walnuts
Sponsor:   Brigham and Women's Hospital
Recruiting - verified April 2014

BIOFLOW-III Canada Satellite Registry

Conditions:   Coronary Artery Disease;   Myocardial Ischemia
Intervention:  
Sponsor:   Biotronik Canada Inc
Not yet recruiting - verified June 2013

A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following Hospitalization for Heart Failure

Conditions:   Heart Failure;   Coronary Artery Disease
Interventions:   Drug: Rivaroxaban;   Drug: Placebo;   Other: Standard of care for heart failure and coronary artery disease
Sponsor:   Janssen Research & Development, LLC
Recruiting - verified April 2014

Application for Self-Monitoring of Cardiovascular Risk

Condition:   Coronary Artery Disease Which Requires Percutaneous Coronary Intervention(Balloon and/or Stent Treatment).
Intervention:   Device: Self Monitoring Software Application
Sponsor:   Mayo Clinic
Recruiting - verified April 2014

Cerebral Oximetry and Perioperative Outcome in Non-Cardiac Surgery

Conditions:   High Risk Non-cardiac Surgery;   Death;   Delirium;   Kidney Injury;   Myocardial Infarction;   Respiratory Failure;   Postoperative Infection
Intervention:   Other: Observational study
Sponsors:   University of Manitoba;   Canadian Anesthesia Research Foundation;   University of Manitoba Department of Anesthesia
Not yet recruiting - verified April 2014

Effects of Linagliptin on Renal Endothelium Function in Patients With Type 2 Diabetes.

Condition:   Type 2-diabetes
Interventions:   Drug: Linagliptin;   Drug: Placebo
Sponsor:   University of Erlangen-Nürnberg Medical School
Completed - verified April 2014

GLobal Assessment of Plaque reGression With a PCSK9 antibOdy as Measured by intraVascular Ultrasound

Condition:   Hypercholesterolemia
Interventions:   Drug: Evolocumab (AMG 145);   Other: Placebo
Sponsor:   Amgen
Recruiting - verified April 2014

Safety Study of PZ-128 in Subjects With Multiple Coronary Artery Disease Risk Factors

Conditions:   Vascular Disease;   Coronary Artery Disease Risk Factors Multiple
Intervention:   Drug: PZ-128
Sponsors:   Tufts Medical Center;   National Heart, Lung, and Blood Institute (NHLBI);   Sinai Hospital of Baltimore
Recruiting - verified April 2014

Intranasal Insulin: A Novel Treatment for Gulf War Multisymptom Illness

Condition:   Chronic Multisymptom Illness in Gulf War Veterans
Intervention:   Device: Intranasal Insulin
Sponsors:   Bronx Veterans Medical Research Foundation, Inc;   VA Boston Healthcare System;   Boston University
Not yet recruiting - verified April 2014

Effect of Prasugrel Versus Clopidogrel on Platelet Function After Bivalirudin Cessation

Condition:   Coronary Artery Disease
Interventions:   Drug: Prasugrel;   Drug: Clopidogrel
Sponsor:   Tufts Medical Center
Recruiting - verified April 2014

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention & Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute
Recruiting - verified April 2014

A Study of Allogeneic Mesenchymal Bone Marrow Cells in Subjects With ST Segment Elevation Myocardial Infarction (STEMI)

Conditions:   ST Segment Elevation Myocardial Infarction (STEMI);   Allogeneic Mesenchymal Bone Marrow Cells
Intervention:   Biological: Stem cells
Sponsors:   Stemedica Cell Technologies, Inc.;   Mercy Gilbert Medical Center at AZ;   Chandler Regional Medical Center at Chandler AZ;   University of California, San Diego
Recruiting - verified April 2014

ABSORB FIRST is a Registry Designed to Evaluate the Safety and Performance of Absorb Bioresorbable Vascular Scaffold (Absorb BVS) Used in Real-world Patients.

Conditions:   Chronic Total Occlusion of Coronary Artery;   Coronary Occlusion;   Coronary Artery Disease;   Coronary Artery Restenosis;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Restenosis
Intervention:   Device: Absorb Bioresorbable Vascular Scaffold
Sponsor:   Abbott Vascular
Recruiting - verified April 2014

Tailored Antiplatelet Therapy Following PCI

Conditions:   Coronary Artery Disease;   Acute Coronary Syndrome;   Stenosis
Interventions:   Drug: Clopidogrel;   Drug: Ticagrelor;   Genetic: Retrospective Genotype testing;   Genetic: Prospective Genotype testing
Sponsors:   Mayo Clinic;   Applied Health Research Centre (AHRC), Toronto, Canada
Recruiting - verified April 2014

Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy

Condition:   Dilated Cardiomyopathy
Interventions:   Biological: ucMSC;   Other: Controls
Sponsor:   Universidad Los Andes
Recruiting - verified April 2014

Copenhagen Study of Obese Patients With Ischemic Heart Disease Undergoing Low Energy Diet or Interval Training

Conditions:   Ischemic Heart Disease;   Obesity
Interventions:   Other: Interval Training;   Other: Weight Loss
Sponsors:   Bispebjerg Hospital;   Eva Prescott;   University of Copenhagen;   Amager Hospital;   Copenhagen University Hospital at Herlev;   Copenhagen University Hospital, Hvidovre;   Rigshospitalet, Denmark;   University of California, Davis;   Texas A&M University;   University of Aarhus
Completed - verified April 2014

A Study to Evaluate the Effect of Aleglitazar on Cardiac Energetics and Function in Patients With Type 2 Diabetes Mellitus and no History of Coronary Artery Disease

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: aleglitazar;   Drug: placebo
Sponsor:   Hoffmann-La Roche
Completed - verified April 2014

BIOFLOW-III Austria Satellite Registry

Conditions:   Coronary Artery Disease;   Myocardial Ischemia
Intervention:  
Sponsor:   Biotronik Vertriebs-GmbH
Recruiting - verified April 2013

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab SAR236553 (REGN727)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Other: placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified April 2014

Study to Evaluate Effect of Nebivolol on Angina in Women With Microvascular Disease

Condition:   Microvascular Angina
Intervention:   Drug: Nebivolol
Sponsors:   Massachusetts General Hospital;   Forest Laboratories
Recruiting - verified April 2014

Exercise and Low-Dose Rapamycin in Older Adults With CAD:Cardiac Rehabilitation And Rapamycin in Elderly (CARE) Trial

Conditions:   Aging;   CAD
Intervention:   Drug: Rapamycin
Sponsor:   Mayo Clinic
Recruiting - verified April 2014

Invasive vs Conservative Strategies in Non-ST-elevation Acute Coronary Syndrome and Comorbidities

Condition:   Acute Coronary Syndrome
Intervention:   Procedure: Coronary angiogram
Sponsors:   University of Valencia;   Instituto de Salud Carlos III
Active, not recruiting - verified April 2014

Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave Therapy

Condition:   Coronary Heart Disease (CHD)
Interventions:   Other: Treatment of CHD risk factors;   Drug: Aspirin, Isosorbide mononitrate, Atenolol, Enalapril.;   Drug: Aspirin, Isosorbide mononitrate, Atenolol, Enalapril.;   Procedure: PCA;   Procedure: CABG;   Device: Cardiospec;   Drug: Aspirin, Isosorbide mononitrate, Atenolol, Enalapril
Sponsor:   City Hospital No 40, Saint Petersburg, Russia
Withdrawn - verified April 2014

Evaluating New Radiation Techniques for Cardiovascular Imaging

Condition:   Coronary Disease
Intervention:  
Sponsors:   National Institutes of Health Clinical Center (CC);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2014

Omacor Plus Standard Therapies In Post Myocardial Infarction (MI) Subjects Evaluation: The OPTIMISE Observational Study

Condition:   Myocardial Infarction (MI)
Intervention:  
Sponsor:   Abbott
Active, not recruiting - verified April 2014

A Pivotal Trial to Establish the Efficacy and Long-term Safety of the Parachute Implant System

Conditions:   Congestive Heart Failure;   Left Ventricular (LV) Systolic Dysfunction
Intervention:   Device: CardioKinetix Parachute Implant and All Appropriate Medical Therapy (AAMT)
Sponsor:   CardioKinetix, Inc
Recruiting - verified March 2014

A Phase II Study of the Safety and Efficacy of MPSK3169A in Patients With Coronary Heart Disease or High Risk of Coronary Heart Disease

Condition:   Coronary Heart Disease
Interventions:   Drug: MPSK3169A;   Drug: Placebo;   Drug: MPSK3169A;   Drug: MPSK3169A;   Drug: MPSK3169A;   Drug: MPSK3169A
Sponsor:   Genentech
Completed - verified April 2014

ProspEctive First Evaluation in Chest Pain Trial

Conditions:   Chest Pain;   Shortness of Breath;   Suspected Acute Coronary Syndrome
Interventions:   Procedure: Coronary CT Angiography;   Procedure: Stress Test
Sponsor:   St. Luke's-Roosevelt Hospital Center
Recruiting - verified May 2012

A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Brilinta

Condition:   Acute Coronary Syndromes
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified April 2014

A Study of Characterizing Cognitive Decline and Functional Cardiac Senescence in Healthy Korean Volunteers

Conditions:   Aging;   Mild Cognitive Impairment;   Angina Pectoris
Intervention:  
Sponsors:   Korea Institute of Oriental Medicine;   Daejeon University
Completed - verified April 2014

Pilot Study of Catheter Ablation for Ventricular Tachycardia in Patients With an Implantable Cardioverter Defibrillator

Condition:   Ventricular Tachycardia
Interventions:   Drug: amiodarone;   Drug: sotalol;   Device: Biosense Webster's NAVI-STAR Thermo-Cool
Sponsors:   Duke University;   Duke Clinical Research Institute
Active, not recruiting - verified January 2014

Hormone Therapy, Radiation Therapy, and Steroid 17alpha-monooxygenase TAK-700 in Treating Patients With High-Risk Prostate Cancer

Condition:   Prostate Cancer
Interventions:   Drug: bicalutamide;   Drug: buserelin;   Drug: flutamide;   Drug: goserelin acetate;   Drug: leuprolide acetate;   Drug: orteronel;   Drug: triptorelin
Sponsors:   Radiation Therapy Oncology Group;   National Cancer Institute (NCI)
Recruiting - verified April 2014

Comparison of Drug Eluting Balloon and Drug Eluting Stent

Conditions:   Coronary Artery Disease;   Stable Angina;   Unstable Angina;   NSTEMI
Interventions:   Device: Drug eluting balloon + Bare metal stent;   Device: drug eluting stent (Zotarolimus-eluting stent)
Sponsor:   Seoul National University Bundang Hospital
Recruiting - verified April 2014

Vitamin K to Attenuate Coronary Artery Calcification in Hemodialysis Patients

Condition:   Endstage Kidney Disease
Interventions:   Drug: Vitamin K1;   Drug: Chrystalline Lactose
Sponsors:   Clinical Evaluation Research Unit at Kingston General Hospital;   Dr. Rachel Holden;   Kingston General Hospital
Recruiting - verified April 2014

Evaluating Cardiovascular Phenotypes Using Induced Pluripotent Stem Cells

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   Scripps Translational Science Institute
Enrolling by invitation - verified April 2014

A Study of Dalcetrapib in Patients With Stable Coronary Heart Disease, With Coronary Heart Disease Risk Equivalents or at Elevated Risk for Cardiovascular Disease

Condition:   Cardiovascular Disease, Coronary Heart Disease, Dyslipidemia, Peripheral Arterial Disease (PAD)
Interventions:   Drug: dalcetrapib;   Drug: Placebo;   Other: Background care
Sponsor:   Hoffmann-La Roche
Completed - verified April 2014

Intracoronary Administration of Levosimendan in Cardiac Surgery Patients

Condition:   Myocardial Stunning
Interventions:   Drug: levosimendan;   Drug: Vitamin B 12
Sponsor:   Tampere University Hospital
Recruiting - verified April 2014

Cyclosporine and Prognosis in Acute Myocardial Infarction (MI) Patients

Condition:   ST Elevation Acute Myocardial Infarction
Interventions:   Drug: Injection of Cyclosporin;   Drug: Placebo;   Procedure: Echocardiography
Sponsor:   Hospices Civils de Lyon
Active, not recruiting - verified March 2014

International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Coronary Artery Disease;   Heart Diseases;   Myocardial Ischemia
Interventions:   Procedure: cardiac catheterization;   Procedure: coronary artery bypass graft surgery;   Procedure: percutaneous coronary intervention;   Behavioral: Lifestyle;   Drug: Medication
Sponsors:   New York University School of Medicine;   New York University;   Stanford University;   National Heart, Lung, and Blood Institute (NHLBI);   Albany Stratton VA Medical Center;   Cedars-Sinai Medical Center;   Columbia University;   Duke University;   East Carolina University;   Emory University;   Harvard University;   Massachusetts General Hospital;   Montreal Heart Institute;   University of British Columbia;   University of Missouri, Kansas City;   Vanderbilt University
Recruiting - verified April 2014

A Study of the Safety and Efficacy of Two Different Regimens of Mipomersen in Patients With Familial Hypercholesterolemia and Inadequately Controlled Low-Density Lipoprotein Cholesterol

Conditions:   Hypercholesterolemia;   Heterozygous Familial
Interventions:   Drug: mipomersen sodium 200 mg;   Drug: Placebo;   Drug: mipomersen sodium 70 mg
Sponsors:   Sanofi;   Genzyme, a Sanofi Company
Active, not recruiting - verified April 2014

Prevention of Serious Adverse Events Following Angiography

Conditions:   Acute Renal Failure;   Kidney Disease;   Coronary Artery Disease
Interventions:   Drug: IV isotonic saline;   Drug: IV isotonic bicarbonate;   Drug: N-acetylcysteine;   Drug: Placebo
Sponsors:   Department of Veterans Affairs;   The George Institute
Recruiting - verified April 2014

A Study to Evaluate Fenofibrate Combination With Statin in Chinese Patients With Dyslipidemic

Conditions:   Dyslipidemias;   Cardiovascular Diseases;   Hypertriglyceridemia
Intervention:   Drug: fenofibrate
Sponsors:   Abbott;   RUNDO International Pharmaceuticals Research & Development Co., Ltd
Completed - verified April 2014

Allogeneic Heart Stem Cells to Achieve Myocardial Regeneration

Condition:   Myocardial Infarction
Intervention:   Biological: CAP-1002 Allogeneic Cardiosphere-Derived Cells
Sponsors:   Capricor Inc.;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 2014

Cardiovascular and Torsades de Pointes Monitoring for Pazopanib

Condition:   Carcinoma, Renal Cell
Interventions:   Drug: Pazopanib;   Drug: Other anti-VEGFs
Sponsor:   GlaxoSmithKline
Active, not recruiting - verified April 2014

EXPERT CTO: Evaluation of the XIENCE PRIME™ LL and XIENCE Nano™ Everolimus Eluting Coronary Stent Coronary Stents, Performance, and Technique in Chronic Total Occlusions

Conditions:   Coronary Artery Disease (CAD);   Chronic Total Occlusion (CTO)
Intervention:   Device: CTO Treatment Device
Sponsor:   Abbott Vascular
Active, not recruiting - verified April 2014

Risk Factors for Coronary Artery Calcification and Left Ventricular Hypertrophy in Hemodialysis Patients

Condition:   End Stage Renal Disease
Intervention:  
Sponsors:   University of Alberta;   Massachusetts General Hospital
Recruiting - verified April 2014

Exploring the Efficacy and Safety of Rivaroxaban to Support Elective Percutaneous Coronary Intervention

Condition:   Cardiovascular Disease, Coronary Artery Disease
Interventions:   Drug: UFH;   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939) and UFH
Sponsor:   Bayer
Completed - verified April 2014

Correlation Between Coronary and Carotid Atherosclerotic Disease (CAD) and Links With Clinical Outcomes

Condition:   Atherosclerosis
Intervention:  
Sponsors:   Canadian Atherosclerosis Imaging Network;   Canadian Institutes of Health Research (CIHR)
Recruiting - verified April 2014

ACToR-study : Angiographic CT of Renal Transplantation Candidate - Study

Conditions:   Renal Transplant Candidate for Right Kidney;   Renal Transplant Candidate for Left Kidney
Intervention:  
Sponsor:   University of Aarhus
Completed - verified February 2014

A Study of Dalcetrapib in Patients Hospitalized For An Acute Coronary Syndrome (Dal-ACUTE)

Condition:   Coronary Heart Disease
Interventions:   Drug: dalcetrapib;   Drug: placebo
Sponsor:   Hoffmann-La Roche
Completed - verified April 2014

Effect of Molsidomine on the Endothelial (Internal Layer of Blood Vessels) Dysfunction in Patients With Angina Pectoris

Conditions:   Stable Angina Pectoris;   Atherosclerosis
Interventions:   Drug: Coruno;   Drug: Placebo
Sponsor:   Therabel Pharma SA/NV
Active, not recruiting - verified April 2014

A Study of RO4905417 in Patients With Non ST-Elevation Myocardial Infarction (Non-STEMI) Undergoing Percutaneous Coronary Intervention

Condition:   Myocardial Infarction
Interventions:   Drug: RO4905417;   Drug: RO4905417;   Drug: placebo;   Procedure: Percutaneous Coronary Intervention (PCI)
Sponsor:   Hoffmann-La Roche
Completed - verified April 2014

Xenon Compared to Sevoflurane and Total Intravenous Anaesthesia for Coronary Artery Bypass Graft Surgery

Conditions:   Coronary Artery Disease;   General Anesthetic Drug Allergy;   Coronary Artery Bypass Graft Surgery
Interventions:   Drug: Xenon;   Drug: Sevoflurane;   Drug: Propofol
Sponsors:   Air Liquide Santé International;   Orion Corporation, Orion Pharma
Completed - verified April 2014

Impact of Intraventricular Electrical Activation in Resynchronization Therapy

Conditions:   Heart Failure;   Cardiomyopathy, Dilated;   Coronary Disease
Intervention:   Device: Invasive mapping with CARTO3 system and Non-Invasive mapping with CardioInsight Atlas EC Mapping system
Sponsor:   University Hospital, Bordeaux
Recruiting - verified April 2014

XIENCE V Everolimus Eluting Coronary Stent System (EECSS) China: Post-Approval, Single-Arm Study

Conditions:   Angioplasty;   Chronic Coronary Occlusion;   Stent Thrombosis;   Vascular Disease;   Myocardial Ischemia;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Artery Disease;   Coronary Restenosis
Intervention:   Device: XIENCE V® Everolimus Eluting Coronary Stent System (EECSS)
Sponsor:   Abbott Vascular
Active, not recruiting - verified April 2014

IK-5001 for the Prevention of Remodeling of the Ventricle and Congestive Heart Failure After Acute Myocardial Infarction

Conditions:   Acute Myocardial Infarction;   Congestive Heart Failure;   ST-Elevation Myocardial Infarction
Interventions:   Device: Sodium Alginate and Calcium Gluconate;   Device: Saline Solution
Sponsors:   Bellerophon;   Bellerophon BCM, LLC
Recruiting - verified April 2014

EXCEL Clinical Trial

Conditions:   Chronic Coronary Occlusion;   Unprotected Left Main Coronary Artery Disease;   Stent Thrombosis;   Vascular Disease;   Myocardial Ischemia;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Artery Disease;   Coronary Restenosis
Interventions:   Device: Percutaneous Coronary Intervention;   Procedure: CABG
Sponsor:   Abbott Vascular
Active, not recruiting - verified April 2014

HBPL Study of the Impact of the NK1 Antagonist Aprepitant

Conditions:   Cocaine;   Alcohol Dependence
Interventions:   Drug: Aprepitant;   Drug: Placebo
Sponsors:   University of Pennsylvania;   National Institute on Drug Abuse (NIDA)
Terminated - verified April 2014

Trial of Atorvastatin on the Persistent Coronary Aneurysm in Children With Kawasaki Disease

Conditions:   Kawasaki Disease;   Aneurysm, Coronary
Intervention:   Drug: Atorvastatin
Sponsors:   National Taiwan University Hospital;   National Science Council, Taiwan
Recruiting - verified April 2014

Rubidium-82 - An Alternative Radiopharmaceutical for Myocardial Imaging(Rb-ARMI)

Condition:   Coronary Artery Disease
Intervention:   Other: Myocardial perfusion imaging using Rb-82 PET or Tc-99m or Tl SPECT
Sponsors:   University of Ottawa Heart Institute;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting - verified April 2014

XIENCE V/PROMUS Everolimus-Eluting Stent System Post-marketing Surveillance Protocol for Japan

Conditions:   Angina;   Chronic Coronary Occlusion;   Stent Thrombosis;   Vascular Disease;   Myocardial Ischemia;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Artery Disease;   Coronary Restenosis
Intervention:   Device: XIENCE V / PROMUS stent placement
Sponsor:   Abbott Vascular
Active, not recruiting - verified April 2014

A Study of the Effect of Dalcetrapib on Artherosclerotic Disease in Patients With Coronary Artery Disease

Condition:   Cardiovascular Disease
Interventions:   Drug: dalcetrapib;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Terminated - verified April 2014

Care Transitions for Complex Patient - Cycle 1 and Cycle 2

Conditions:   Asthma;   Coronary Artery Disease;   Diabetes;   Hypertension;   Congestive Heart Failure
Interventions:   Other: Reports;   Other: Reports and Notices;   Other: Usual care
Sponsors:   Duke University;   Northern Piedmont Carolina Community Care Partners;   North Carolina Division of Medical Assistance
Completed - verified February 2014

AFRICA: Atorvastatin Plus Fenofibric Acid (TriLipix) in the Reduction of Intermediate Coronary Atherosclerosis

Condition:   Coronary Atherosclerosis
Interventions:   Drug: Placebo;   Drug: TriLipix
Sponsor:   Piedmont Healthcare
Terminated - verified April 2014

Molecular and Morphologic Characterization of Circulating Endothelial Cells

Condition:   Acute Myocardial Infarction
Intervention:  
Sponsor:   Scripps Translational Science Institute
Recruiting - verified April 2014

Individualized Comprehensive Atherosclerosis Risk-reduction Evaluation Program

Condition:   Atherosclerosis
Intervention:  
Sponsors:   Piedmont Healthcare;   Abbott
Recruiting - verified April 2014

Determinants of Cognitive Impairment After Acute Coronary Syndrome

Condition:   Coronary Syndrome
Intervention:   Other: Brain MRI and cerebral perfusion scintigraphy
Sponsors:   University Hospital, Bordeaux;   Université Victor Segalen Bordeaux 2
Completed - verified April 2014

Detection of Subclinical Atherosclerosis in Asymptomatic Individuals

Condition:   Coronary Artery Disease
Intervention:   Procedure: Cardiac CT
Sponsor:   Piedmont Healthcare
Recruiting - verified April 2014

ABSORB Clinical Investigation, Cohort B

Conditions:   Coronary Disease;   Coronary Artery Disease;   Coronary Restenosis
Intervention:   Device: Bioabsorbable Everolimus Eluting Coronary Stent
Sponsor:   Abbott Vascular
Active, not recruiting - verified April 2014

Validation of Stenosis Assessment by Coronary Artery Computed Tomography Against Invasive Measurements of Fractional Flow Reserve in Patients With Significant Coronary Artery Stenoses

Condition:   Coronary Artery Stenosis
Intervention:   Procedure: FFR, IVUS, VH, or combination of the three
Sponsor:   Piedmont Healthcare
Completed - verified April 2014

Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation

Conditions:   Mitral Valve Insufficiency;   Coronary Artery Disease
Interventions:   Procedure: Mitral Valve Repair with Annuloplasty;   Procedure: Mitral Valve Replacement
Sponsors:   Mount Sinai School of Medicine;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research (CIHR);   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified April 2014

Comparing the Effectiveness of a Mitral Valve Repair Procedure in Combination With Coronary Artery Bypass Grafting (CABG) Versus CABG Alone in People With Moderate Ischemic Mitral Regurgitation

Conditions:   Mitral Valve Insufficiency;   Coronary Artery Disease
Interventions:   Procedure: Mitral Valve Repair;   Procedure: CABG
Sponsors:   Mount Sinai School of Medicine;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research (CIHR);   National Institute of Neurological Disorders and Stroke (NINDS)
Active, not recruiting - verified April 2014

Choice Of Optimal Strategy For Bifurcation Lesions With Normal Side Branch

Condition:   Coronary Artery Disease
Interventions:   Procedure: kissing balloon;   Procedure: without kissing balloon angioplasty "leave alone"
Sponsors:   CardioVascular Research Foundation, Korea;   Seung-Jung Park
Completed - verified April 2014

Prospective Observational Epidemiologic Study of Maraviroc's Safety

Condition:   Human Immunodeficiency Virus
Interventions:   Drug: Maraviroc along with an optimized background antiretroviral drug regimen;   Drug: Optimized background antiretroviral drug regimen without maraviroc
Sponsors:   ViiV Healthcare;   Pfizer
Active, not recruiting - verified April 2014

A Study of the Effect of RO4607381 on Atherosclerotic Plaque in Patients With Coronary Heart Disease

Condition:   Coronary Heart Disease
Interventions:   Drug: dalcetrapib;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Completed - verified April 2014

A Study Assessing the Effect of RO4607381 on Vascular Function in Patients With Coronary Heart Disease (CHD) or CHD-Risk Equivalent Patients

Condition:   Coronary Heart Disease
Interventions:   Drug: dalcetrapib;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Completed - verified April 2014

Advanced Cardiovascular Imaging Consortium

Conditions:   Chest Pain;   Coronary Occlusion;   Coronary Artery Disease
Intervention:  
Sponsors:   William Beaumont Hospitals;   Blue Cross Blue Shield of Michigan Foundation
Completed - verified April 2014

Prevention of Contrast Nephropathy During Diagnostic Coronary Angiogram or PCI With Hydratation Based on LEVDP

Conditions:   Radiographic Contrast Agent Nephropathy;   Renal Failure;   Coronary Heart Disease
Interventions:   Drug: Normal saline and sodium bicarbonate;   Drug: normal saline;   Drug: Sodium bicarbonate
Sponsor:   Université de Sherbrooke
Recruiting - verified April 2014

Risk Reduction in Coronary Heart Disease

Condition:   Coronary Heart Disease
Interventions:   Behavioral: smoking cessation;   Drug: betablocker, diuretics, ACEI, ARB,;   Drug: statins, ezetimibe;   Behavioral: training;   Biological: influenza vaccine;   Drug: metformin, glimepiride, insulin;   Behavioral: weight reduction
Sponsors:   Sorlandet Hospital HF;   Oslo University Hospital
Recruiting - verified April 2014

A Long Term Extension of Study NC19453 Evaluating Safety and Efficacy of RO4607381

Condition:   Coronary Heart Disease
Interventions:   Drug: dalcetrapib;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Completed - verified April 2014

A Study of RO4607381 in Patients With Coronary Heart Disease (CHD) or a CHD Risk Equivalent.

Condition:   Coronary Heart Disease
Interventions:   Drug: dalcetrapib;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Completed - verified April 2014

Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth

Conditions:   Coronary Artery Disease;   Coronary Artery Stenosis
Intervention:   Device: Coronary stent implantation
Sponsor:   OrbusNeich
Completed - verified April 2014

Cell Repair in Heart Failure

Conditions:   Heart Failure;   Ischemia
Intervention:   Procedure: Retrograde coronary venous delivery of cells.
Sponsor:   Imperial College London
Withdrawn - verified February 2006

Nurses' Health Study (Cardiovascular Component)

Conditions:   Cardiovascular Diseases;   Diabetes Mellitus;   Coronary Disease;   Heart Diseases;   Cerebrovascular Accident;   Pulmonary Embolism;   Angina Pectoris;   Myocardial Infarction;   Menopause;   Postmenopause
Intervention:  
Sponsors:   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2014

Women's Ischemia Syndrome Evaluation (WISE)

Conditions:   Angina Pectoris;   Cardiovascular Diseases;   Coronary Disease;   Heart Diseases;   Myocardial Ischemia
Interventions:   Procedure: Angiography, MRI, Dobutamine-Stress Echocardiography, PET,;   Procedure: Myocardial Contrast Echo, Coronary Flow and Vasomotor Testing
Sponsors:   University of Pittsburgh;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2014

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