Coronary Artery Disease

Clinical Trial Finder

Many patients with coronary artery disease are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Identification of the Blood Microbiota in Patient Suffering From Myocardial Infraction

Conditions:   Coronary Disease;   Myocardial Infarction
Intervention:  
Sponsor:   University Hospital, Toulouse
Recruiting - verified March 2015

PRV-based Detection of CAD in Comparison to Standard Methods

Condition:   Coronary Artery Disease
Intervention:   Other: Diagnostic algorithm
Sponsor:   University Medicine Greifswald
Not yet recruiting - verified March 2015

Clinical Utility of an Age, Sex, and Gene Expression Score

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   CardioDx
Completed - verified March 2015

Biomime Stent in All-comers PCI Patients Registry

Condition:   Coronary Artery Disease
Intervention:   Device: percutaneous coronary intervention
Sponsor:   Azienda Ospedaliero Universitaria Maggiore della Carita
Recruiting - verified March 2015

Clinical Cohorts in Coronary Disease Collaboration

Condition:   Coronary Heart Disease
Intervention:  
Sponsors:   University College, London;   Barts & The London NHS Trust;   University of Bristol;   University of York
Completed - verified March 2015

Pericardial Fat and Inflammation in HIV Patients and Controls

Conditions:   Coronary Artery Disease;   Human Immunodeficiency Virus (HIV)
Intervention:  
Sponsor:   University of Cincinnati
Recruiting - verified January 2015

Aerobic Exercise and Oxygen Uptake Efficiency Slope in Coronary Artery Disease

Condition:   Coronary Artery Disease
Intervention:   Other: Aerobic exercise training
Sponsor:   Hospital TotalCor
Completed - verified March 2015

An Assessment of the Glider Balloon in Complex Lesions

Condition:   Coronary Artery Disease
Intervention:   Device: PTCA Balloon Angioplasty
Sponsor:   TriReme Medical, LLC
Recruiting - verified March 2015

MagicTouch Sirolimus Drug Coated Balloon Catheter for the Treatment of Coronary Lesions

Condition:   Coronary Artery Disease
Intervention:   Device: MAGIC-TOUCH Drug-eluting Balloon
Sponsor:   Scitech Produtos Medicos Ltda
Not yet recruiting - verified March 2015

Epigenetic Reprogramming of Monocytes in Patients With Coronary Atherosclerosis

Condition:   Atherosclerosis
Intervention:  
Sponsors:   Radboud University;   Canisius-Wilhelmina Hospital
Recruiting - verified March 2015

4 vs 6 Implants in Totally Edentulous Patient in Maxilla With Ti. Cad-cam Framework

Condition:   Edentulous Maxilla
Intervention:   Device: 4 vs 6 implant treatment in the maxilla
Sponsor:   Institute Franci
Recruiting - verified March 2015

COMBinAtion Therapy in Myocardial Infarction: The COMBAT-MI Trial

Condition:   ST Elevation Acute Myocardial Infarction
Interventions:   Drug: Exenatide;   Other: Remote Ischemic Conditioning (RIC)
Sponsor:   Hospital Universitari Vall d'Hebron Research Institute
Not yet recruiting - verified March 2015

Trial of Supportive Text Messages for Patients With Alcohol Use Disorder and a Co-morbid Depression

Condition:   Dual Diagnosis
Interventions:   Other: Supportive text messages intervention;   Other: Control group
Sponsors:   St Patrick's Hospital, Ireland;   University of Dublin, Trinity College
Not yet recruiting - verified March 2015

Relationship Between Diet, Lifestyle, and the Severity of Coronary Artery Disease

Conditions:   Dietary Habits;   Coronary Artery Disease;   Lifestyle
Intervention:   Behavioral: Survey
Sponsor:   New York University School of Medicine
Recruiting - verified March 2015

Sub Lingual Versus Traditional Oral Administration of Ticagrelor in Acute Coronary Syndrome/Non ST-elevation Myocardial Infarction - A Platelet Reactivity Study

Conditions:   Acute Coronary Syndromes;   Non ST Elevation Myocardial Infarction
Intervention:   Drug: Sub Lingual Ticagrelor
Sponsor:   Sheba Medical Center
Not yet recruiting - verified March 2015

Acute Myocardial Infarction Quality Assurance Project

Conditions:   Myocardial Infarction;   Death;   Heart Failure
Interventions:   Other: Quality Assurance Implementation;   Other: Standard of Care
Sponsor:   Dr. Derek Exner
Recruiting - verified March 2015

Transversus Abdominis Plane Versus Caudal Block for Pediatrics

Condition:   Lower Abdominal Surgery
Interventions:   Other: Transversus abdominis plane block;   Other: Caudal block;   Drug: Bupivacaine
Sponsor:   Mansoura University
Recruiting - verified March 2015

Effect of Family-Centered Empowerment Model

Condition:   Acute Myocardial Infarction: Rehabilitation Phase
Intervention:   Other: Family-centered empowerment model
Sponsors:   Baqiyatallah Medical Sciences University;   Tarbiat Modarres University
Completed - verified March 2015

Myocardial Protection and Anesthetic Agents

Condition:   Myocardial Ischemic Reperfusion Injury
Interventions:   Drug: Remifentanil;   Drug: Dexmedetomidine;   Drug: Sevoflurane
Sponsor:   Cukurova University
Recruiting - verified March 2015

Pd/Pa vs iFR™ in an Unselected Population Referred for Invasive Angiography

Conditions:   Coronary Artery Disease;   Plaque;   Atherosclerosis;   Fractional Flow Reserve
Intervention:  
Sponsor:   Golden Jubilee National Hospital
Recruiting - verified March 2015

A Study to Evaluate the Effects of Azilsartan on Coronary Artery Plaque in Essential Hypertensive Patients With Stable Angina and Dyslipidemia

Condition:   Essential Hypertension With Stable Angina and Dyslipidemia
Intervention:   Drug: Azilsartan
Sponsor:   Takeda
Not yet recruiting - verified March 2015

Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine

Condition:   Coronary Artery Disease
Interventions:   Drug: Methylnaltrexone;   Other: Placebo;   Drug: Morphine;   Drug: Ticagrelor
Sponsor:   University of Florida
Not yet recruiting - verified March 2015

Study Comparing the MiStent SES Versus the XIENCE EES Stent

Condition:   Coronary Stenosis
Interventions:   Device: MiStent;   Device: XIENCE EES
Sponsors:   ECRI bv;   Micell Technologies;   Stentys
Not yet recruiting - verified February 2015

Safety and Efficacy of the CRE8 Stent for the Treatment of De Novo Coronary Artery Lesions

Condition:   Coronary Artery Disease
Interventions:   Device: CRE8 sirolimus-eluting stent;   Device: RESOLUTE zotarolimus-eluting stent
Sponsor:   CID S.p.A.
Recruiting - verified March 2015

Safety and Efficacy of the CRE8 Sirolimus-Eluting Stent for the Treatment of De Novo Coronary Artery Lesions

Condition:   Coronary Artery Disease
Intervention:   Device: CRE8 sirolimus-eluting stent
Sponsor:   CID S.p.A.
Recruiting - verified March 2015

Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease

Condition:   Coronary Artery Disease
Interventions:   Procedure: Computed tomography angiography (cardiac CT);   Procedure: Invasive coronary angiography (ICA)
Sponsor:   Charite University, Berlin, Germany
Not yet recruiting - verified March 2015

Endothelial Function-guided Therapy Compared to Usual Care in Patients With NOCAD

Condition:   Coronary Atherosclerosis
Intervention:  
Sponsor:   Itamar-Medical, Israel
Not yet recruiting - verified March 2015

Mechanisms of Social Inequalities in Post-hospitalization Rehabilitation in Patients With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   Nordsjaellands Hospital
Recruiting - verified March 2015

Eggs as Part of a Healthy Breakfast

Condition:   Cardiovascular Diseases
Interventions:   Other: Eggs - 2 per day for breakfast;   Other: 1 packet of oatmeal per day
Sponsor:   University of Connecticut
Active, not recruiting - verified March 2015

A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Acetylsalicylic acid;   Drug: Rivaroxaban;   Drug: Clopidogrel;   Drug: Ticagrelor
Sponsors:   Janssen Research & Development, LLC;   Bayer;   Duke Clinical Research Institute;   Harvard Medical School
Not yet recruiting - verified March 2015

RuSsian RegisTry of Acute CoronaRy SyndromE TreAtMent and Approach in Dual Antiplatelet Therapy

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   AstraZeneca
Not yet recruiting - verified March 2015

A Clinical Trial on the Candidate Vaccine cAd3-EBOZ in Healthy Adults in Switzerland

Condition:   Ebola Vaccines
Intervention:   Biological: cAd3-EBOZ
Sponsors:   University of Lausanne Hospitals;   Infectious Disease Service, CHUV, Lausanne;   Policlinique Médicale Universitaire;   Clinical Trial Unit, Lausanne University Hospital;   Swiss Tropical & Public Health Institute;   University of Lausanne;   GlaxoSmithKline;   World Health Organization
Active, not recruiting - verified March 2015

Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Pilot Study in Healthy Volunteers

Conditions:   Myocardial Infarction;   Inflammation;   Acute Coronary Syndrome (ACS);   Reperfusion Injury
Interventions:   Biological: Salmonella typhi vaccine (Typhim Vi®);   Drug: Oxygen (Oxymask®);   Drug: Atorvastatin
Sponsors:   Karolinska Institutet;   University Hospital, Linkoeping
Recruiting - verified March 2015

Extension (OLE) Study to Assess Safety and Efficacy of Evolocumab

Condition:   Hypercholesterolemia
Intervention:   Biological: Evolocumab
Sponsor:   Amgen
Enrolling by invitation - verified March 2015

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified March 2015

Pharmacogenomics of Antiplatelet Response

Condition:   Atherosclerosis
Intervention:   Drug: Aspirin
Sponsor:   Johns Hopkins University
Recruiting - verified March 2015

OCT Study of the MGuard Prime Stent in Patients With Heart Attacks

Condition:   ST Segment Elevated Myocardial Infarction
Interventions:   Device: MGuard Prime;   Device: Control BMS DES
Sponsor:   InspireMD
Withdrawn - verified March 2015

Using Ripple Mapping to Guide Substrate Ablation of Scar Related Ventricular Tachycardia.

Conditions:   Monomorphic Ventricular Tachycardia;   Myocardial Infarction;   Dilated Cardiomyopathy
Interventions:   Device: Ripple Mapping guided VT ablation;   Device: Conventional VT ablation
Sponsor:   Imperial College London
Recruiting - verified July 2014

Mainz Intracoronary Database. The Coronary Slow-flow and Microvascular Diseases Registery

Conditions:   Coronary Artery Disease;   Microvascular Dysfunction
Intervention:   Other: observational only- no intervention
Sponsor:   Johannes Gutenberg University Mainz
Recruiting - verified March 2015

Canadian SCAD Study

Condition:   Spontaneous Coronary Artery Dissection
Intervention:  
Sponsors:   Cardiology Research UBC;   Canadian Institutes of Health Research  (CIHR)
Recruiting - verified March 2015

Pharmacokinetics of Everolimus in ABSORB BVS in Patients With Coronary Artery Lesions

Conditions:   Coronary Artery Disease;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Stenosis
Intervention:   Device: Coronary artery stenting: ABSORB BVS
Sponsor:   Abbott Vascular
Active, not recruiting - verified March 2015

Is Efficacy of PLAtelet Aggregation Inhibition by Ticagrelor Mediated P2Y12 Blockade Dependent Upon Endogenous Endothelial Nitric OXide?

Condition:   Acute Coronary Syndome
Interventions:   Other: Blood Test;   Other: EndoPAT - endothelial assessment
Sponsor:   Jennifer Rossington
Not yet recruiting - verified March 2015

Opsens Optowire for Fractional Flow Reserve - The O2 Pilot Study

Conditions:   Stable Angina;   Unstable Angina Pectoris;   Chest Pain;   Ischemia
Intervention:   Device: Fractional flow reserve measurement
Sponsors:   Laval University;   Opsens Medical;   International Chair on Interventional Cardiology and Transradial Approach
Recruiting - verified March 2015

BioFreedom US IDE Feasibility Trial

Conditions:   Ischemic Heart Disease;   Stable Angina;   Unstable Angina;   Silent Ischemia
Intervention:   Device: BioFreedom drug coated coronary stent
Sponsor:   Biosensors Europe SA
Active, not recruiting - verified March 2015

Accuracy of an Echo-Stress Protocol Using Regadenoson With Speckle Tracking

Condition:   Ischemia
Intervention:   Drug: Regadenoson
Sponsors:   M.D. Anderson Cancer Center;   Astellas Scientific & Medical Affairs, Inc.
Recruiting - verified March 2015

Copeptin Testing During Pre-hospital Care in the Treatment of Chest Pain Suggestive of Acute Coronary Syndrome

Condition:   Chest Pain
Interventions:   Biological: Blood work in the ambulance;   Biological: Blood work upon arrival in the emergency room;   Biological: Blood work at 3 hours post-arrival in the emergency room
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Not yet recruiting - verified March 2015

Short-term Dual Anti Platelet Therapy in Patients With ACS Treated With the COMBO Dual-therapy Stent

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Treatment 3 months DAPT;   Drug: Treatment 12 months DAPT
Sponsor:   Diagram B.V.
Recruiting - verified March 2015

A Phase 2b Study of CSL112 in Subjects With Acute Myocardial Infarction.

Condition:   Acute Myocardial Infarction
Interventions:   Biological: CSL112;   Biological: Placebo
Sponsor:   CSL Behring
Recruiting - verified March 2015

Coronary Artery Disease Screening in Kidney Transplant Candidates

Conditions:   End Stage Renal Disease;   Coronary Artery Disease
Intervention:   Other: Selective Screening
Sponsor:   University of British Columbia
Recruiting - verified March 2015

A Phase II Study of Androgen Deprivation Therapy With or Without PD 0332991 in RB-Positive Metastatic Prostate Cancer

Condition:   Prostate Cancer
Interventions:   Drug: PD 0332991;   Drug: Bicalutamide;   Drug: Zoladex;   Drug: Lupron Depot
Sponsors:   University of Michigan Cancer Center;   University of Utah;   Vanderbilt-Ingram Cancer Center;   Dana-Farber Cancer Institute;   Johns Hopkins University;   Thomas Jefferson University
Recruiting - verified March 2015

Transition From Ticagrelor to Clopidogrel Following Acute Coronary Syndrome: To Bolus or Not?

Condition:   Acute Coronary Syndrome
Intervention:   Drug: Clopidogrel
Sponsor:   Ottawa Heart Institute Research Corporation
Completed - verified March 2015

Use of Abbott High Sensitivity Troponin I Assay In Acute Coronary Syndromes

Conditions:   Acute Coronary Syndrome;   Myocardial Infarction;   Troponin
Intervention:  
Sponsors:   Minneapolis Medical Research Foundation;   Abbott Diagnostics Division;   Hennepin County Medical Center, Minneapolis
Active, not recruiting - verified March 2015

A Pharmacodynamic Study of a Personalized Strategy for P2Y12 Inhibition Versus Ticagrelor in Reducing Ischemic and Bleeding Risk

Conditions:   Acute Coronary Syndrome;   Percutaneous Coronary Intervention
Intervention:   Drug: Ticagrelor,  Prasugrel, Clopidogrel
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research  (CIHR)
Recruiting - verified March 2015

Statin and Angiotensin-converting Enzyme Inhibitor on Symptoms in Patients With SCAD

Condition:   Coronary Artery Dissection, Spontaneous
Interventions:   Drug: ramipril;   Drug: rosuvastatin;   Drug: placebo
Sponsor:   Cardiology Research UBC
Recruiting - verified July 2014

Routine Versus Selective Use of FFR to Guide PCI

Conditions:   Acute Coronary Syndrome;   Coronary Atherosclerosis;   Angina, Unstable
Intervention:   Device: Fractional Flow Reserve (FFR)
Sponsors:   Cardiology Research UBC;   Provincial Health Services Authority
Terminated - verified March 2015

Prevalence of Morbidity in Newly Diagnosed type2 Diabetes in Adults

Conditions:   Type2 Diabetes Mellitus;   Complications
Intervention:   Other: no specific treatment
Sponsors:   University of Algiers;   National Institute of public Health, Algeria;   Ain-Taya's hospital, Algiers;   Parnet's teaching Hospital, Algiers;   Mustapha Pacha's teaching hospital, Algiers;   Birtraria's teaching hospital, Algiers;   Bab el Oued's teaching hospital, Algiers
Completed - verified March 2015

The TRansendocardial Stem Cell Injection Delivery Effects on Neomyogenesis STudy (The TRIDENT Study)

Condition:   Chronic Ischemic Left Ventricular Dysfunction Secondary to Myocardial Infarction.
Intervention:   Biological: Allogeneic hMSCs
Sponsors:   Joshua M Hare;   The EMMES Corporation
Active, not recruiting - verified March 2015

A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Ticagrelor 90 mg;   Drug: Ticagrelor placebo
Sponsor:   AstraZeneca
Recruiting - verified March 2015

STem cElls Mobilization in Acute Myocardial Infarction Outcome Trial

Conditions:   Anterior Acute Myocardial Infarction;   Left Ventricular Systolic Dysfunction
Intervention:   Drug: G-CSF administration
Sponsors:   Heart Care Foundation;   A. Manzoni Hospital;   Centro Cardiologico Monzino
Recruiting - verified March 2015

Testing Responsiveness to Platelet Inhibition on Chronic Antiplatelet Treatment For Acute Coronary Syndromes Trial

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Prasugrel;   Drug: Clopidogrel
Sponsor:   Klinikum der Universitaet Muenchen
Recruiting - verified March 2015

Transplantation of Human Embryonic Stem Cell-derived Progenitors in Severe Heart Failure

Condition:   Ischemic Heart Disease
Intervention:   Biological: Human embryonic stem cell-derived CD15+ Isl-1+ progenitors
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting - verified May 2013

Study of Tenecteplase Versus Alteplase for Thrombolysis (Clot Dissolving) in Acute Ischemic Stroke

Condition:   Ischemic Stroke
Interventions:   Drug: Tenecteplase;   Drug: Alteplase
Sponsors:   Lars Thomassen;   The Research Council of Norway
Recruiting - verified March 2015

Prevention of Cardiovascular Events by Antiplatelet Agents After Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified March 2015

Study of GSK1278863 to Reduce Ischemic Events in Patients Undergoing Thoracic Aortic Aneurysm Repair

Condition:   Surgical Procedures
Interventions:   Drug: GSK1278863;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Active, not recruiting - verified March 2015

Application for Self-Monitoring of Cardiovascular Risk

Condition:   Coronary Artery Disease Which Requires Percutaneous Coronary Intervention(Balloon and/or Stent Treatment).
Intervention:   Device: Self Monitoring Software Application
Sponsor:   Mayo Clinic
Active, not recruiting - verified March 2015

Influence of FFR on the Clinical Outcome After Percutaneous Coronary Intervention

Condition:   Coronary Disease
Intervention:  
Sponsors:   Inje University;   Seoul National University Hospital;   Keimyung University Dongsan Medical Center;   Ulsan University Hospital;   Hallym University Medical Center;   Kangdong Sacred Heart Hospital;   Busan Veterans General Hospital;   Myongji Hospital;   Chungbuk National University Hospital;   Hanyang University;   Dong-A University Hospital;   Gyeongsang National University Hospital
Recruiting - verified March 2015

PROMISE Substudy to Assess For Effective Dose of Radiation (PROMISE-SAFER) Specific Aim 3b

Conditions:   Chest Pain;   Coronary Artery Disease;   Angina
Intervention:  
Sponsors:   Kaiser Permanente;   Columbia University
Active, not recruiting - verified March 2015

Effect of Isoflurane on Tissue Doppler Imaging of Mitral Annulus During Cardiac Surgery

Conditions:   Valvular Heart Disease;   Ischemic Heart Disease
Intervention:   Drug: Isoflurane
Sponsor:   Konkuk University Medical Center
Completed - verified March 2015

The Treatment of Coronary Artery Lesions Using the PRO-Kinetic Energy Cobalt-Chromium, Bare-Metal Stent

Condition:   Coronary Artery Disease
Intervention:   Device: PRO-Kinetic Energy Stent
Sponsor:   Biotronik AG
Terminated - verified March 2015

Mainz Registry of Flow-mediated Constriction

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   Johannes Gutenberg University Mainz
Recruiting - verified March 2015

Mindful Hearts Study

Conditions:   Cardiovascular Disease;   Psychological Stress;   Stroke;   Coronary Artery Disease
Interventions:   Behavioral: Mindfulness Based Stress Reduction;   Behavioral: Health Education Program
Sponsor:   Department of Veterans Affairs
Recruiting - verified March 2015

Lipoprotein Apheresis in Refractory Angina Study

Conditions:   Refractory Angina;   Raised Lipoprotein(a)>50mg/dL or >500mg/L
Interventions:   Other: Lipoprotein Apheresis;   Other: Sham Apheresis
Sponsors:   Imperial College London;   National Institute for Health Research, United Kingdom
Active, not recruiting - verified February 2013

An Efficacy and Outcome Study of Supplemental Oxygen Treatment in Patients With Suspected Myocardial Infarction

Conditions:   Acute Coronary Syndrome;   Non-ST Elevation (NSTEMI) Myocardial Infarction;   Acute ST Segment Elevation Myocardial Infarction;   Angina, Unstable
Intervention:   Drug: Oxygen
Sponsors:   Karolinska Institutet;   Swedish Heart Lung Foundation;   Swedish Foundation for Strategic Research;   The Swedish Research Council
Recruiting - verified March 2015

Kinetics of Troponin and BNP in Breast Cancer Chemotherapy With Adriamycin and Trastuzumab

Condition:   Breast Cancer
Intervention:  
Sponsor:   Mayo Clinic
Enrolling by invitation - verified March 2015

Coronary Artery Calcification Score and Risk Factors for Coronary Artery Disease in Persons With Spinal Cord Injury

Condition:   Spinal Cord Injury
Intervention:  
Sponsor:   James J. Peters Veterans Affairs Medical Center
Recruiting - verified March 2015

REgister of Myocardial Infarction Patients Treated by the NOVAra STE-MI Network

Condition:   Acute Myocardial Infarction
Intervention:   Device: Primary PCI
Sponsor:   Azienda Ospedaliero Universitaria Maggiore della Carita
Recruiting - verified March 2015

Complete vs Culprit-only Revascularization to Treat Multi-vessel Disease After Primary PCI for STEMI

Conditions:   Acute Myocardial Infarction;   Coronary Artery Disease;   Percutaneous Coronary Intervention
Intervention:   Procedure: Complete Revascularization Strategy
Sponsor:   Population Health Research Institute
Recruiting - verified March 2015

Does Optical Coherence Tomography Optimise Results of Stenting

Condition:   Acute Coronary Syndromes
Intervention:   Procedure: OCT
Sponsor:   Centre Hospitalier Universitaire de Besancon
Recruiting - verified March 2015

Trial on the Effect of Adalimumab on Vascular Inflammation in Patients With Psoriasis

Conditions:   Psoriasis;   Vascular Inflammation;   Coronary Atherosclerosis
Interventions:   Biological: Adalimumab;   Other: Placebo
Sponsors:   Innovaderm Research Inc.;   Abbott;   Montreal Heart Institute
Active, not recruiting - verified September 2014

Single Long vs Two Short Overlapping Bioabsorbable Polymer DES

Condition:   Coronary Artery Disease
Intervention:   Device: implantation of a bioabsorbable polymer DES
Sponsor:   Azienda Ospedaliero Universitaria Maggiore della Carita
Recruiting - verified March 2015

Ceramic Versus Composite in the Treatment of Posterior Teeth by Inlays or Onlays

Conditions:   Dental Caries;   Inlays
Interventions:   Device: ceramic (Empress CAD, Ivoclar Vivadent);   Device: composite (Lava Ultimate, 3M Espe)
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Ministry of Health, France;   Hôpital Charles Foix;   Hôtel Dieu - Service d'odontologie (Toulouse);   Dental practitionners
Active, not recruiting - verified May 2012

Endothelium, Stenting, and Antiplatelet Therapy (EST) - Clopidogrel, Prasugrel, Ticagrelor Study

Condition:   Coronary Artery Disease
Interventions:   Procedure: Coronary stenting;   Drug: Ticagrelor;   Drug: Clopidogrel;   Drug: Prasugrel
Sponsor:   Johannes Gutenberg University Mainz
Recruiting - verified March 2015

The Impact of Gratitude on Biology and Behavior in Persons With Heart Disease

Conditions:   Myocardial Infarction;   Unstable Angina
Intervention:  
Sponsors:   Massachusetts General Hospital;   University of California, Berkeley
Completed - verified March 2015

Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease-2

Condition:   Coronary Heart Disease
Interventions:   Other: 3T CMR;   Other: SPECT;   Other: CT calcium score;   Other: CT coronary angiography;   Other: X-Ray coronary angiography
Sponsors:   University of Leeds;   University of Leicester;   University of Glasgow;   British Heart Foundation
Active, not recruiting - verified March 2015

Optimal Physiologic Intravascular Ultrasound Imaging Criteria After Drug Eluting Stent Implantation

Condition:   Coronary Disease
Intervention:  
Sponsors:   Inje University;   Seoul National University Hospital
Completed - verified March 2015

HeartTrends Heart Rate Variability (HRV) Algorithm for the Diagnosis of Myocardial Ischemia

Condition:   Ischemic Heart Disease
Intervention:  
Sponsor:   Sheba Medical Center
Completed - verified March 2015

Absolute Quantification of Coronary Flow Reserve by Stress Perfusion MRI

Condition:   Myocardial Ischemia
Interventions:   Drug: Regadenoson;   Drug: gadofoveset trisodium
Sponsors:   Northwestern University;   Astellas Pharma Global Development, Inc.
Completed - verified March 2015

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab SAR236553 (REGN727)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Other: placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified March 2015

SmartTouch Catheter in Ablation of Ventricular Tachycardia

Conditions:   Arrhythmias, Cardiac;   Tachycardia, Ventricular;   Myocardial Infarction;   Cardiomyopathies
Intervention:  
Sponsors:   Hospital Universitario Virgen de la Arrixaca;   Biosense Webster, Inc.
Active, not recruiting - verified March 2015

WEUKBRE5554: IMI PROTECT(Work Package 2): Beta2 Agonists and Acute Myocardial Infarction

Condition:   Asthma
Intervention:   Drug: Inhaled LABA use
Sponsor:   GlaxoSmithKline
Completed - verified March 2015

Invasive vs Conservative Strategies in Non-ST-elevation Acute Coronary Syndrome and Comorbidities

Condition:   Acute Coronary Syndrome
Intervention:   Procedure: Coronary angiogram
Sponsors:   University of Valencia;   Instituto de Salud Carlos III
Completed - verified April 2014

China PEACE-Prospective PCI Study

Condition:   Coronary Heart Disease
Intervention:  
Sponsors:   China National Center for Cardiovascular Diseases;   Ministry of Health, China
Active, not recruiting - verified March 2015

Evaluating New Radiation Techniques for Cardiovascular Imaging

Condition:   Coronary Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2015

Acute Versus Subacute Angioplasty in Patients With NON-ST-Elevation Myocardial Infarction

Condition:   Myocardial Infarction
Intervention:   Procedure: Group I: Primary PCI
Sponsor:   Aarhus University Hospital Skejby
Recruiting - verified March 2015

Antiplatelet Therapy Guided by Thrombelastography in Patients With Acute Coronary Syndromes (TEGCOR Study)

Conditions:   Thrombosis;   Coronary Artery Disease
Interventions:   Drug: Prasugrel;   Drug: Clopidogrel
Sponsor:   Indiana University
Recruiting - verified March 2015

A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Brilinta

Condition:   Acute Coronary Syndromes
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified March 2015

SONOlysis in Risk REduction of Symptomatic and Silent Brain infarCtions dUring Cardiac surgEry

Conditions:   Coronary Artery Bypass Graft Redo;   Heart Valve Diseases
Interventions:   Procedure: sonolysis;   Procedure: cardiac surgery
Sponsors:   University Hospital Ostrava;   Palacky University;   Ministry of Health, Czech Republic
Recruiting - verified March 2015

BIOFLOW-III All-comers Orsiro Safety and Performance Registry

Conditions:   Coronary Artery Disease;   Myocardial Ischemia
Intervention:  
Sponsor:   Biotronik AG
Active, not recruiting - verified March 2015

CorMatrix ECM Study: To Identify Inflammatory Markers Following CABG With/Without ECM

Condition:   Coronary Artery Disease
Intervention:   Device: CorMatrix extra cellular matrix (ECM)
Sponsors:   Inova Health Care Services;   CorMatrix Cardiovascular, Inc.
Active, not recruiting - verified March 2015

Prevalence and Long-term Impact of Non-atherosclerotic CAD

Condition:   Myocardial Infarction
Intervention:  
Sponsors:   Cardiology Research UBC;   University of British Columbia
Recruiting - verified March 2015

Effects of N-acetylcysteine on Low T3 Syndrome

Conditions:   Acute Myocardial Infarction;   Euthyroid Sick Syndrome;   Ischemic Heart Disease
Intervention:   Drug: N-acetylcysteine
Sponsors:   Federal University of Rio Grande do Sul;   Hospital de Clinicas de Porto Alegre;   Programa de pós-graduação em endocrinologia
Completed - verified March 2015

Prevention of Serious Adverse Events Following Angiography

Conditions:   Acute Renal Failure;   Kidney Disease;   Coronary Artery Disease
Interventions:   Drug: IV isotonic saline;   Drug: IV isotonic bicarbonate;   Drug: N-acetylcysteine;   Drug: Placebo
Sponsors:   Department of Veterans Affairs;   The George Institute
Recruiting - verified March 2015

Cardiovascular and Torsades de Pointes Monitoring for Pazopanib

Condition:   Carcinoma, Renal Cell
Interventions:   Drug: Pazopanib;   Drug: Other anti-VEGFs
Sponsor:   GlaxoSmithKline
Completed - verified March 2015

Allogeneic Heart Stem Cells to Achieve Myocardial Regeneration

Condition:   Myocardial Infarction
Intervention:   Biological: CAP-1002 Allogeneic Cardiosphere-Derived Cells
Sponsors:   Capricor Inc.;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2015

VH-IVUS Plaque Composition Analysis By Fractional Flow Reserve

Condition:   Coronary Disease
Intervention:  
Sponsors:   Inje University;   Seoul National University Hospital
Completed - verified March 2015

Diagnostic Performances of Computed TomographIc Coronary Angiography and Intravascular Ultrasound

Condition:   Diagnosis Coronary Artery Disease
Intervention:   Procedure: diagnostic procedures CCTA, CAG, IVUS and FFR
Sponsors:   Seoul National University Hospital;   Inje University
Completed - verified March 2015

Femoral Versus Radial Access for Primary PCI

Condition:   Myocardial Infarction
Intervention:   Procedure: Radial access site vs. Femoral Access site
Sponsor:   Ottawa Heart Institute Research Corporation
Recruiting - verified March 2015

Ticagrelor and Aspirin for the Prevention of Cardiovascular Events After Coronary Artery Bypass Surgery

Condition:   Coronary Artery Disease
Interventions:   Drug: ticagrelor;   Drug: Placebo
Sponsors:   Cardiology Research UBC;   University of British Columbia
Completed - verified March 2013

Validation/Evaluation of Multimodal Imaging Combining 3D Ultrasound and Stress Myocardial Scintigraphy in the Diagnosis of Coronary Artery Disease

Conditions:   Coronary Artery Disease;   Coronary Disease
Interventions:   Procedure: Stress ultrasound;   Procedure: Scintigraphy;   Procedure: Coronary angiography
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Withdrawn - verified March 2015

A Study of the Safety and Efficacy of Injectable Thymosin Beta 4 for Treating Acute Myocardial Infarction

Conditions:   Acute Myocardial Infarction;   ST Elevation Myocardial Infarction;   STEMI
Interventions:   Drug: Drug: Placebo;   Drug: Drug: Injectable Thymosin beta 4
Sponsor:   RegeneRx Biopharmaceuticals, Inc.
Suspended - verified November 2012

XIENCE V Everolimus Eluting Coronary Stent System (EECSS) China: Post-Approval, Single-Arm Study

Conditions:   Angioplasty;   Chronic Coronary Occlusion;   Stent Thrombosis;   Vascular Disease;   Myocardial Ischemia;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Artery Disease;   Coronary Restenosis
Intervention:   Device: XIENCE V® Everolimus Eluting Coronary Stent System (EECSS)
Sponsor:   Abbott Vascular
Active, not recruiting - verified March 2015

Omega 3 Fatty Acid Efficiency for Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting

Conditions:   Ischemic Heart Disease;   Atrial Fibrillation
Interventions:   Drug: Omega-3 fish oil emulsion (Omegaven);   Drug: Intralipid
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Terminated - verified March 2015

Treatment of Coronary Artery Disease (CAD) With Bare Metal Stent (BMS) Followed by Paclitaxel-Coated Balloon Catheter Versus Paclitaxel-Eluting Stent

Condition:   Coronary Artery Disease
Interventions:   Device: Coroflex Blue (BMS) followed by SeQuent Please (DEB);   Device: Coroflex Please (DES)
Sponsor:   Aesculap AG
Active, not recruiting - verified March 2015

Rubidium-82 Position Emission Computed Tomography (PET) Versus Gated, Rest / Stress Technetium 99-m SPECT

Conditions:   Coronary Artery Disease;   Myocardial Ischemia;   Heart Disease
Interventions:   Other: SPECT imaging;   Other: PET imaging
Sponsors:   Hartford Hospital;   Bracco Diagnostics, Inc
Completed - verified July 2012

EArly Discharge After Transradial Stenting of CoronarY Arteries in High-Risk Patients of Bleeding

Condition:   Coronary Artery Disease
Interventions:   Drug: Bivalirudin;   Drug: Heparin
Sponsor:   Laval University
Recruiting - verified March 2015

A Trial of Telmisartan Prevention of Cardiovascular Disease

Condition:   Hypertension
Interventions:   Drug: Non-ARB (standard therapy);   Drug: ARB (Telmisartan)
Sponsors:   Kumamoto University;   Japan Foundation For Aging And Health
Active, not recruiting - verified March 2015

Plaque REgression With Cholesterol Absorption Inhibitor or Synthesis Inhibitor Evaluated by IntraVascular UltraSound

Conditions:   Hypercholesterolemia;   Coronary Artery Disease
Interventions:   Drug: Combination therapy with Lipitor [Atorvastatin] and Zetia [Ezetimibe];   Drug: Lipitor (Atorvastatin) monotherapy
Sponsor:   Kumamoto University
Completed - verified March 2015

A Study to Evaluate 3 Different Dosing Regimens of Mipomersen Administered Via Subcutaneous Injections to Healthy Volunteers

Condition:   Healthy Volunteer
Interventions:   Drug: mipomersen;   Drug: Placebo
Sponsors:   Genzyme, a Sanofi Company;   Isis Pharmaceuticals
Completed - verified March 2015

Frailty as an INstrument for Evaluation of Elderly Patients With Non ST Elevation Myocardial Infarction (NSTEMI)

Conditions:   Non ST Elevation Myocardial Infarction (NSTEMI);   Frailty
Intervention:  
Sponsors:   Linkoeping University;   Medical Research Council
Completed - verified March 2015

Strict or Liberal Insulin Protocol Following Coronary Artery Bypass Graft (CABG) Surgery

Conditions:   Blood Glucose;   Coronary Artery Bypass;   Insulin;   Coronary Disease
Intervention:   Other: LIBERAL
Sponsor:   Inova Health Care Services
Active, not recruiting - verified March 2015

Long-term Evaluation of Patients Receiving Bone Marrow-derived Cell Administration for Heart Disease

Conditions:   Acute Myocardial Infarction;   Ischemic Cardiomyopathy;   Dilated Cardiomyopathy;   Heart Failure
Intervention:   Biological: autologous bone marrow-derived cells
Sponsor:   Johann Wolfgang Goethe University Hospitals
Recruiting - verified March 2015

AngelMed for Early Recognition and Treatment of STEMI

Conditions:   Acute Myocardial Infarction (AMI);   Coronary Occlusion;   Acute Coronary Syndrome
Intervention:   Device: AngelMed Guardian System
Sponsors:   Angel Medical Systems;   Symbios Clinical
Active, not recruiting - verified July 2013

A Phase 1 Safety Study of the Intravenous Administration of Thymosin Beta in Healthy Volunteers

Conditions:   Myocardial Infarction;   Myocardial Ischemia
Interventions:   Drug: thymosin beta 4;   Other: Placebo
Sponsor:   RegeneRx Biopharmaceuticals, Inc.
Completed - verified March 2015

Effects of Intracoronary Progenitor Cell Therapy on Coronary Flow Reserve After Acute MI

Conditions:   Coronary Artery Disease;   Acute Myocardial Infarction
Interventions:   Biological: autologous bone marrow-derived progenitor cells;   Biological: placebo medium
Sponsors:   Johann Wolfgang Goethe University Hospitals;   University of Leipzig
Terminated - verified March 2015

Study to Assess the Tolerability and Efficacy of Anacetrapib in Patients With Coronary Heart Disease (CHD) or CHD Risk-Equivalent Disease (MK-0859-019)

Conditions:   Coronary Heart Disease (CHD);   CHD Risk-Equivalent Disease
Interventions:   Drug: anacetrapib;   Drug: Comparator: placebo
Sponsor:   Merck Sharp & Dohme Corp.
Active, not recruiting - verified March 2015

French Registry of Acute Coronary Syndrome

Condition:   Acute Myocardial Infarction
Intervention:   Other: Blood sample
Sponsors:   Assistance Publique - Hôpitaux de Paris;   French Cardiology Society
Active, not recruiting - verified March 2015

Targeting Inflammation Using Salsalate in CardioVascular Disease

Conditions:   Coronary Artery Disease;   Overweight
Interventions:   Drug: Salsalate;   Drug: Placebo
Sponsors:   Allison Goldfine;   Beth Israel Deaconess Medical Center;   Tufts Medical Center
Active, not recruiting - verified March 2015

Stem Cell Study for Subjects With Congestive Heart Failure

Conditions:   Myocardial Ischemia;   Congestive Heart Failure;   Cardiovascular Disease
Intervention:   Biological: Intramyocardial injection of autologous CD34-positive cells (stem cells)
Sponsor:   Losordo, Douglas, M.D.
Terminated - verified November 2011

A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease

Condition:   Moderate Risk of CVD
Interventions:   Drug: Aspirin (Acetylsalicylic acid, BAYE4465);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting - verified March 2015

Effects of Pioglitazone in Type 2 Diabetes Mellitus and Coronary Heart Disease

Conditions:   Type 2 Diabetes Mellitus;   Cardiovascular Disease
Interventions:   Drug: pioglitazone;   Drug: placebo
Sponsors:   IKFE Institute for Clinical Research and Development;   Takeda;   Johannes Gutenberg University Mainz;   Heidelberg University
Completed - verified May 2007

hsCRP in Japan Statin Treatment Against Recurrent Stroke (J-STARS hsCRP)

Condition:   Ischemic Stroke
Intervention:   Drug: Statin
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Ministry of Health, Labour and Welfare, Japan;   Hiroshima University;   Osaka University
Active, not recruiting - verified March 2015

Cell-Wave Study: Combined Extracorporal Shock Wave Therapy and Intracoronary Cell Therapy in Chronic Ischemic Myocardium

Condition:   Congestive Heart Failure
Intervention:   Procedure: intracoronary stem cell therapy
Sponsor:   Johann Wolfgang Goethe University Hospitals
Completed - verified March 2015

Assessing Myocardial Blood Flow and Blood Flow Reserve by Transoesophageal Echocardiography (TEE)

Condition:   Coronary Artery Disease
Interventions:   Drug: SonoVue;   Drug: Optison
Sponsor:   University Hospital, Basel, Switzerland
Withdrawn - verified March 2015

Cell Repair in Heart Failure

Conditions:   Heart Failure;   Ischemia
Intervention:   Procedure: Retrograde coronary venous delivery of cells.
Sponsor:   Imperial College London
Withdrawn - verified March 2015

Stem Cell Mobilization and VEGF Gene Transfer for Heart Failure

Condition:   Ischemic Congestive Heart Failure (CHF)
Intervention:   Genetic: Vascular Endothelial Growth Factor (VEGF1)
Sponsor:   Losordo, Douglas, M.D.
Withdrawn - verified June 2009

SB-480848 In Subjects With Coronary Heart Disease

Condition:   Atherosclerosis
Intervention:   Drug: SB-480848
Sponsor:   GlaxoSmithKline
Completed - verified March 2015

Vascular Aging: The Link That Bridges Age to Atherosclerosis (The VALIDATE Study)

Conditions:   Atherosclerosis;   Cardiovascular Disease;   Vascular Diseases
Intervention:  
Sponsor:   National Institute on Aging (NIA)
Active, not recruiting - verified July 2014

Testosterone and Myocardial Perfusion in CHD

Condition:   Coronary Heart Disease
Intervention:   Drug: Testosterone undecanoate
Sponsors:   Imperial College London;   Organon
Completed - verified October 2005

Japan Statin Treatment Against Recurrent Stroke (J-STARS)

Condition:   Ischemic Stroke
Intervention:   Drug: Pravastatin
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Ministry of Health, Labour and Welfare, Japan;   Hiroshima University
Active, not recruiting - verified March 2015

Autoimmunity and Coronary Artery Disease - Ancillary to CARDIA

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Heart Diseases
Intervention:  
Sponsors:   Northwestern University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified March 2015

Health Professionals Follow-up Study

Conditions:   Cardiovascular Diseases;   Cerebrovascular Accident;   Coronary Disease;   Peripheral Vascular Diseases;   Heart Diseases;   Myocardial Infarction
Intervention:  
Sponsors:   Harvard School of Public Health;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified March 2013

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