Cardio-Oncology: Fluoropyrimidine Chemotherapy Treatment with 5-fluorouracil (5FU) or capecitabine

Fluoropyrimidine Chemotherapy

Cancer Types Treated

Many cancer types are treated with chemotherapy using fluoropyrimidine including:

  • Gastrointestinal cancers, including colorectal cancer, anal cancer, some stomach cancers
  • Breast cancer 
  • Lung cancer 
  • Esophageal cancer 
  • Head and neck cancer 

Other cancers also receive this treatment:

  • Hepatobiliary cancers (liver or gallbladder)
  • Ovarian, fallopian tube, or peritoneal cancers 
  • Neuroendocrine (islet cell tumors)
  • Pancreatic cancer

Chemotherapy may be given through a tube placed in a vein as an intravenous (IV) medication or with a pill taken by mouth. The IV form, 5-flourouracil, is given either continuously over hours or as one dose over minutes. The pill, capecitabine, may be taken twice a day.

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Published: January 2019
Authors: Suparna Clasen, MD; Rupal O’Quinn, MD, FACC; Joseph R. Carver, MD, FACC
Medical Reviewers: Deb Sundloff, DO, FACC; Bonnie Ky, MD, MSCE, FACC

These modules were developed in collaboration with the Eastern Cooperative Group—American College of Radiology Imaging Network (ECOG-ACRIN) Cardiotoxicity Working Group and Patient Advocacy Group.

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