Cardio-Oncology: Fluoropyrimidine Chemotherapy Treatment with 5-fluorouracil (5FU) or capecitabine

Fluoropyrimidine Chemotherapy

Cancer Types Treated


Many cancer types are treated with chemotherapy using fluoropyrimidine including:

  • Gastrointestinal cancers, including colorectal cancer, anal cancer, some stomach cancers
  • Breast cancer 
  • Lung cancer 
  • Esophageal cancer 
  • Head and neck cancer 

Other cancers also receive this treatment:

  • Hepatobiliary cancers (liver or gallbladder)
  • Ovarian, fallopian tube, or peritoneal cancers 
  • Neuroendocrine (islet cell tumors)
  • Pancreatic cancer

Chemotherapy may be given through a tube placed in a vein as an intravenous (IV) medication or with a pill taken by mouth. The IV form, 5-flourouracil, is given either continuously over hours or as one dose over minutes. The pill, capecitabine, may be taken twice a day.

< Back Next >

Published: January 2019
Authors: Suparna Clasen, MD; Rupal O’Quinn, MD, FACC; Joseph R. Carver, MD, FACC
Medical Reviewers: Deb Sundloff, DO, FACC; Bonnie Ky, MD, MSCE, FACC

These modules were developed in collaboration with the Eastern Cooperative Group—American College of Radiology Imaging Network (ECOG-ACRIN) Cardiotoxicity Working Group and Patient Advocacy Group.

Welcome to CardioSmart

Learn how to make the most of trusted heart health information, incentive programs, health tracking tools and mobile resources available at CardioSmart.org.

Patient Resource