Cardiomyopathy

Clinical Trial Finder

Many patients with cardiomyopathy are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Stem Cell Injection in Cancer Survivors

Condition:   Cardiomyopathy Due to Anthracyclines
Interventions:   Biological: Allo-MSCs;   Biological: Placebo
Sponsors:   The University of Texas Health Science Center, Houston;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified July 2015

European Sleep Apnea and Sudden CArdiac Death ProjEct

Conditions:   Sleep Apnea;   Sudden Cardiac Death;   Heart Failure;   Ischemic Cardiomyopathy
Intervention:   Device: Positive Airway Pressure Therapy
Sponsors:   University Hospital Olomouc;   Mayo Clinic
Not yet recruiting - verified July 2015

Combination of Mesenchymal and C-kit+ Cardiac Stem Cells as Regenerative Therapy for Heart Failure

Condition:   Ischemic Cardiomyopathy
Interventions:   Biological: Mesenchymal Stem Cells (MSC);   Biological: Cardiac Stem Cells (CSC);   Biological: Placebo (Plasmalyte A)
Sponsors:   The University of Texas Health Science Center, Houston;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified July 2015

Myocardial Deformation in Real-time 3D Ultrasound. Normal Values in Adults and Validation Against the Tagged MRI

Condition:   Myocardial Infarction
Interventions:   Other: MRI;   Other: 3D cardiac ultrasound
Sponsor:   University Hospital, Caen
Recruiting - verified July 2015

Therapy of Preconditioned Autologous BMMSCs for Patients With Ischemic Heart Disease

Conditions:   Myocardial Infarction;   Acute Myocardial Infarction;   Ischemic Cardiomyopathy
Intervention:   Biological: BMMSCs
Sponsors:   Academy Military Medical Science, China;   Sun Yat-sen University
Not yet recruiting - verified July 2015

Comparing the Effects of Spironolactone With Chlortalidone on LV Mass and Arterial Stiffness in Patients With CKD

Conditions:   Renal Insufficiency, Chronic;   Cardio-Renal Syndrome
Interventions:   Drug: Spironolactone;   Drug: chlortalidone;   Device: Ambulatory blood pressure monitor®;   Device: Carotid femoral pulse wave velocity;   Procedure: Cardiac magnetic resonance imaging;   Procedure: Blood tests;   Procedure: Spot urine collection for albumin:creatinine ratio
Sponsors:   University Hospital Birmingham;   Royal Free Hospital NHS Foundation Trust;   University of Edinburgh;   University of Cambridge
Recruiting - verified July 2015

Liver Function Measured by HepQuant-SHUNT in the Prediction of Outcomes in Patients With Heart Disease

Conditions:   Liver Disease;   Cardiovascular Disease
Intervention:   Drug: Cholate testing
Sponsors:   Northwestern University;   University of Colorado, Denver
Enrolling by invitation - verified July 2015

Myocardial Regional Function by Dobutamine Stress Echocardiography in the Metabolic Syndrome and Type 2 Diabetes

Condition:   Diabetes-related Complications
Intervention:   Drug: dobutamine
Sponsor:   University of Avignon
Recruiting - verified July 2015

Evaluation of Breathing, Sleep and the Effects of Continuous Positive Airway Pressure During Wakefulness in Children With Heart Failure

Condition:   Heart Failure
Interventions:   Other: Effect of CPAP on respiratory work and cardiac function indices during wakefulness;   Other: Effect of CPAP on respiratory work and cardiac function indices during wakefulness;   Other: Effect of CPAP on respiratory work and cardiac function indices during wakefulness;   Device: CPAP
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Philips Healthcare
Recruiting - verified July 2015

A Rollover Study of ARRY-371797 in Patients With LMNA-Related Dilated Cardiomyopathy

Condition:   LMNA-Related Dilated Cardiomyopathy
Intervention:   Drug: ARRY-371797, p38 inhibitor, oral
Sponsor:   Array BioPharma
Recruiting - verified July 2015

Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-461

Condition:   Hypertrophic Cardiomyopathy
Intervention:   Drug: MYK-461
Sponsor:   MyoKardia, Inc.
Recruiting - verified July 2015

ENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)

Condition:   Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)
Interventions:   Drug: Revusiran (ALN-TTRSC);   Drug: Sterile Normal Saline (0.9% NaCl)
Sponsor:   Alnylam Pharmaceuticals
Recruiting - verified July 2015

DISCOVERY: A Study Examining the Prevalence of TTR Mutations in Subjects Suspected of Having Cardiac Amyloidosis

Condition:   Familial Amyloidotic Cardiomyopathy (FAC)
Intervention:  
Sponsor:   Alnylam Pharmaceuticals
Recruiting - verified July 2015

A Pilot Study of Transcoronary Myocardial Cooling

Condition:   Acute Myocardial Infarction
Interventions:   Other: Cohort A - Room temperature coronary perfusate;   Other: Cohort B - Cooled coronary perfusate
Sponsor:   Royal Brompton & Harefield NHS Foundation Trust
Completed - verified July 2015

Screening of Fabry Disease in Patients With Left Ventricular Hypertrophy Detected in Echocardiography

Condition:   Left Ventricular Hypertrophy
Intervention:  
Sponsor:   Laurence Gabriel
Recruiting - verified July 2015

Infusion Intracoronary of Mononuclear Autologous Adult no Expanded Stem Cells of Bone Marrow on Functional Recovery in Patients With Idiopathic Dilated Cardiomyopathy and Heart Failure.

Condition:   Idiopathic Dilated Cardiomyopathy
Interventions:   Drug: Infusion of autologous mononuclear bone marrow cells;   Drug: Placebo infusion
Sponsors:   Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud;   Iniciativa Andaluza en Terapias Avanzadas 
Recruiting - verified June 2015

Burden of Disease Study In Patients With Transthyretin Familial Amyloidosis Polyneuropathy (TTR-FAP) orTransthyretin Cardiomyopathy (TTR-CM) And Caregivers

Conditions:   Transthyretin Familial Amyloidosis Polyneuropathy (TTR-FAP);   Transthyretin Cardiomyopathy (TTR-CM);   Familial Amyloid Cardiomyopathy;   Senile Systemic Amyloidosis (SSA)
Interventions:   Other: No drug;   Other: No drug
Sponsor:   Pfizer
Active, not recruiting - verified July 2015

Radial Strain ECHO-Guided Implantation of Cardiac Resynchronization Therapy

Condition:   Ischemic Cardiomyopathy
Intervention:   Procedure: Echo guided implantation group
Sponsors:   Sheba Medical Center;   Tel-Aviv Sourasky Medical Center;   Rabin Medical Center;   Rambam Health Care Campus;   Kaplan Medical Center;   Soroka University Medical Center;   Mayo Clinic
Recruiting - verified July 2015

Palliative Care in Heart Failure

Conditions:   Heart Failure;   Heart Diseases;   Cardiovascular Diseases
Intervention:   Behavioral: Usual heart failure care + interdisciplinary palliative care
Sponsors:   Duke University;   National Institute of Nursing Research (NINR)
Active, not recruiting - verified July 2015

PercutaneOus StEm Cell Injection Delivery Effects On Neomyogenesis in Dilated CardioMyopathy (The POSEIDON-DCM Study)

Condition:   Non-ischemic Dilated Cardiomyopathy
Interventions:   Procedure: Transendocardial injection;   Biological: Autologous hMSCs;   Biological: Allogeneic hMSCs
Sponsors:   Joshua M Hare;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified July 2015

Nonmyeloablative Allo Stem Cell Transplant for Severe Autoimmune Diseases

Conditions:   Systemic Lupus Erythematosus;   Systemic Sclerosis
Intervention:   Procedure: Nonmyeloablative allogeneic stem cell transplant
Sponsor:   Duke University
Terminated - verified July 2015

Transthyretin-Associated Amyloidoses Outcome Survey (THAOS)

Conditions:   Transthyretin Mutations;   Transthyretin Amyloidosis
Intervention:   Other: None. Observational Study.
Sponsor:   Pfizer
Recruiting - verified July 2015

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