Cardiomyopathy

Clinical Trial Finder

Many patients with cardiomyopathy are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Edema and Fibrosis CMR Imaging in Cardiomyopathy

Condition:   Cardiomyopathies
Intervention:   Device: 7 T CMR
Sponsor:   University of Pennsylvania
Recruiting

Risk of Pacing-induced Cardiomyopathy

Conditions:   Pacemaker DDD;   Atrioventricular Block;   Pacing-Induced Cardiomyopathy
Intervention:   Device: Right ventricular pacing
Sponsors:   Aalborg University Hospital;   Svend Andersens Foundation;   Peacs;   Aalborg University
Recruiting

First-in-Human Study of NI006 in Patients With Amyloid Transthyretin Cardiomyopathy

Condition:   Amyloid Transthyretin Cardiomyopathy
Interventions:   Drug: NI006;   Drug: Placebo
Sponsor:   Neurimmune AG
Recruiting

Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Interventions:   Behavioral: Lifestyle;   Drug: Sacubitril/Valsartan
Sponsors:   Newcastle University;   Azienda Ospedaliero-Universitaria Careggi;   University Hospital Regensburg;   Institute for Cardiovascular Diseases of Vojvodina;   University of Belgrade
Recruiting

Study of Myocardial Deformation Parameters in Patients With Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Intervention:  
Sponsor:   AHEPA University Hospital
Active, not recruiting

APOLLO-B: A Study to Evaluate Patisiran in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)

Condition:   Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Interventions:   Drug: Placebo;   Drug: Patisiran
Sponsor:   Alnylam Pharmaceuticals
Recruiting

A Biomarker and MRI Study on Troponin Release After Exercise in Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Intervention:  
Sponsor:   Heartcenter, University Medical Center St. Radboud
Completed

Study of Efficacy of Oral Sacubitril/Valsartan in Adult Patients With Non-obstructive Hypertrophic Cardiomyopathy

Condition:   Cardiomyopathy, Hypertrophic
Interventions:   Drug: LCZ696;   Drug: Placebo
Sponsor:   Novartis Pharmaceuticals
Recruiting

HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Condition:   Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Interventions:   Drug: Vutrisiran;   Drug: Sterile Normal Saline (0.9% NaCl)
Sponsor:   Alnylam Pharmaceuticals
Recruiting

A Rollover Study of ARRY-371797 in Patients With LMNA-Related Dilated Cardiomyopathy

Condition:   LMNA-Related Dilated Cardiomyopathy
Intervention:   Drug: ARRY-371797, p38 inhibitor, oral
Sponsor:   Pfizer
Active, not recruiting

Catheter Ablation for Nonsustained Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy

Conditions:   Ventricular Tachycardia;   Ischemic Cardiomyopathy;   Reduced LVEF
Interventions:   Procedure: VT ablation;   Other: medication
Sponsor:   Heinrich-Heine University, Duesseldorf
Recruiting

Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion

Conditions:   Sepsis;   Cardiomyopathies;   Hypoperfusion;   Left Ventricular Systolic Dysfunction
Interventions:   Drug: Placebos;   Drug: Dobutamine
Sponsors:   University Hospital, Limoges;   Centre d’Investigation Clinique 1415
Recruiting

Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Cardiomyopathy

Conditions:   Amyloidosis;   Amyloid Cardiomyopathy;   Transthyretin Amyloidosis;   Cardiomyopathies;   Heart Diseases
Interventions:   Drug: AG10;   Drug: Placebo Oral Tablet
Sponsor:   Eidos Therapeutics
Recruiting

CorCinch-HF Repair System in Patients Who Present With Symptomatic Non-Ischemic or Ischemic Dilated Cardiomyopathy

Conditions:   Heart Failure With Reduced Ejection Fraction (HFrEF);   Dilated Cardiomyopathy
Interventions:   Device: AccuCinch Ventricular Repair System;   Drug: Guideline-Directed Medical Therapy
Sponsor:   Ancora Heart, Inc.
Not yet recruiting

A Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CT-G20 in Subjects With Obstructive Hypertrophic Cardiomyopathy

Condition:   Cardiomyopathy, Hypertrophic Obstructive
Interventions:   Drug: CT-20;   Drug: Placebo
Sponsor:   Celltrion
Recruiting

Epidemiological Analysis for the Hereditary Transthytetin-related Amyloidosis (hATTR)

Conditions:   Transthyretin Amyloidosis;   Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy;   Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy;   Polyneuropathies;   Cardiomyopathies
Intervention:  
Sponsor:   Centogene AG Rostock
Recruiting

Vyndaqel Capsules Special Investigation (ATTR-CM)

Condition:   Transthyretin (TTR) Amyloid Cardiomyopathy
Intervention:   Drug: Treatment for TTR amyloidosis
Sponsor:   Pfizer
Recruiting

A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction Therapy

Condition:   HOCM, Hypertrophic Obstructive Cardiomyopathy
Interventions:   Drug: Mavacamten;   Drug: Placebo
Sponsor:   MyoKardia, Inc.
Not yet recruiting

Analysis of Both Sex and Device Specific Factors on Outcomes in Patients With Non-Ischemic Cardiomyopathy

Conditions:   Cardiomyopathies;   Gender;   Implantable Defibrillator User
Intervention:  
Sponsors:   Biotronik, Inc.;   University of Rochester
Recruiting

REDWOOD-HCM: Randomized Evaluation of Dosing With CK-3773274 in Obstructive Outflow Disease in HCM

Condition:   Obstructive Hypertrophic Cardiomyopathy
Interventions:   Drug: CK-3773274 (5 - 15 mg);   Drug: CK-3773274 (10 - 30 mg);   Drug: Placebo for CK-3773274
Sponsor:   Cytokinetics
Recruiting

The Broken Heart Study II (BHS-II)

Condition:   Takotsubo Cardiomyopathy
Intervention:   Other: Stress reactivity test
Sponsors:   The Miriam Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

Genetic Predictors of Outcome in HCM Patients

Condition:   Hypertrophic Cardiomyopathy
Intervention:  
Sponsor:   University of Pittsburgh
Active, not recruiting

An Early Feasibility Evaluation of the AccuCinch® Ventricular Repair System in Patients With Heart Failure and Reduced Ejection Fraction (HFrEF) - The CorCinch-HFrEF Study

Conditions:   Heart Failure;   Cardiomyopathy, Dilated
Intervention:   Device: AccuCinch® Ventricular Repair
Sponsor:   Ancora Heart, Inc.
Recruiting

The Correlation Between Gut Microbiome-host Interaction and Ventricular Arrhythmias.

Condition:   Gut Microbiome
Intervention:   Diagnostic Test: device interrogation
Sponsor:   North Florida Foundation for Research and Education
Not yet recruiting

Implantable Cardioverter Defibrillator (ICD Registry)

Conditions:   Heart Failure;   Nonischemic Cardiomyopathy;   Ischemic Cardiomyopathy;   Ventricular Arrhythmia;   Complications; Device, Cardiac
Intervention:  
Sponsor:   American College of Cardiology
Recruiting

Genetic Markers of Cardiovascular Disease in Epilepsy

Conditions:   Epilepsy;   Seizures;   Syncope;   Channelopathy;   Cardiomyopathies
Intervention:  
Sponsors:   Mayo Clinic;   American Heart Association
Recruiting

Study of the Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA Damage

Conditions:   HIV-1 Seropositive;   Inflammation;   Cancer;   Cardiomyopathy
Intervention:  
Sponsor:   National Institute of Environmental Health Sciences (NIEHS)
Enrolling by invitation

Efficacy and Safety of Implantable Cardioverter-Defibrillator (ICD) Implantation in the Elderly

Conditions:   Cardiomyopathy;   Coronary Artery Disease;   Congestive Heart Failure;   Myocardial Infarction
Interventions:   Device: Implantable Cardioverter Defibrillator;   Other: Optimal Medical Therapy
Sponsor:   VA Office of Research and Development
Active, not recruiting

HbA1c as an Early Serologic Marker for the Hemodynamic Progression of Stage A Heart Failure

Condition:   Heart Failure, Diastolic
Intervention:   Diagnostic Test: Glycosylated hemoglobin
Sponsor:   Parkview Medical Center
Active, not recruiting

Cardiopulmonary and Right Ventricular Function in Health and Disease

Conditions:   Heart Failure;   Athletes Heart
Intervention:  
Sponsor:   University of Colorado, Denver
Recruiting

Mechanical Dyssynchrony in CRT

Conditions:   Left Ventricular Dyssynchrony;   Heart Failure;   Cardiomyopathy, Dilated;   Cardiac Remodeling, Ventricular
Interventions:   Device: Cardiac resynchronization therapy ON;   Device: Cardiac resynchronization therapy OFF
Sponsor:   Universitaire Ziekenhuizen Leuven
Not yet recruiting

MRI Sequence and Imaging Protocol Development

Conditions:   Cardiomyopathy, Hypertrophic;   Cardiomyopathy, Dilated;   Left Ventricular Hypertrophy;   Ischemic Heart Disease;   Hypertension
Intervention:   Other: Cardiovascular Magnetic Resonance
Sponsor:   National Heart Centre Singapore
Recruiting

Reducing Lung CongestIon Symptoms in Advanced Heart Failure

Condition:   Heart Failure
Interventions:   Device: V-Wave Interatrial Shunt;   Other: Control
Sponsor:   V-Wave Ltd
Recruiting

Evaluation of Myocardial Injury After Anthracycline Chemotherapy in Osteosarcoma Patients Using CMR

Conditions:   Cardiotoxicity;   Osteosarcoma;   Myocardial Injury;   Chemotherapy Induced Systolic Dysfunction;   Doxorubicin Induced Cardiomyopathy
Intervention:   Diagnostic Test: contrast-enhanced cardiac magnetic resonance imaging(MAGNETOM Aera 1.5T)
Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University
Recruiting

Technical Development of Cardiovascular Magnetic Resonance Imaging

Conditions:   Cardiomyopathy;   Congenital Heart Disease;   Cardiovascular Disease;   Cardiac Magnetic Resonance Imaging;   Acute Myocardial Infarction
Intervention:   Device: Siemens MRI scanner
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Suspended

A Study to Evaluate Whether Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease

Condition:   Heart Failure With Preserved Ejection Fraction
Interventions:   Drug: Macitentan;   Drug: Placebo
Sponsor:   Actelion
Active, not recruiting

Early Feasibility Study of the Percutaneous 4Tech TriCinch Coil Tricuspid Valve Repair System

Conditions:   Functional Tricuspid Regurgitation;   Heart Valve Diseases;   Tricuspid Valve Insufficiency
Intervention:   Device: Tricinch Coil System Implantation
Sponsor:   4Tech Cardio Ltd.
Recruiting

A Study to Test the Effect of Empagliflozin in Patients Who Are in Hospital for Acute Heart Failure

Condition:   Heart Failure
Interventions:   Drug: Empagliflozin;   Drug: Placebo to Empagliflozin
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting

Biomarkers of Acute Stroke in Clinic

Conditions:   Ischemic Stroke;   Ischemia;   Atrial Fibrillation;   Transient Ischemic Attack;   Transient Cerebrovascular Events;   Thrombotic Stroke;   Stroke;   Stroke, Acute;   Stroke, Ischemic;   Stroke, Complication;   Stroke of Basilar Artery;   Atherosclerosis;   Atheroma;   Cardioembolic Stroke;   Cardiomyopathies;   Cardiovascular Stroke;   Thromboembolism
Intervention:   Diagnostic Test: ISCDX blood test
Sponsor:   Ischemia Care LLC
Recruiting

MRI of Myocardial Infarction

Conditions:   Myocardial Infarction;   Myocardial Ischemia;   Myocardial Injury;   Myocardial Fibrosis;   Myocardial Reperfusion Injury;   Myocardial Edema;   Myocardial Necrosis;   Heart Failure;   Ischemic Heart Disease;   Ischemic Cardiomyopathy;   Hemorrhage
Intervention:  
Sponsor:   University of Pennsylvania
Recruiting

Study of Itacitinib for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation

Conditions:   Acute Myelogenous Leukemia;   Acute Lymphocytic Leukemia;   Myelodysplastic Syndromes;   Non-Hodgkin Lymphoma;   Hodgkin Disease
Interventions:   Procedure: Stem cell transplantation;   Drug: Itacitinib;   Other: Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT);   Other: Human Activity Profile
Sponsors:   Washington University School of Medicine;   Incyte Corporation;   American Society of Hematology
Recruiting

TRILUMINATE Pivotal Trial

Condition:   Tricuspid Regurgitation
Intervention:   Device: Tricuspid valve repair
Sponsor:   Abbott Medical Devices
Recruiting

SMART Watch Facilitated Early Discharge in Patients Undergoing Transcatheter Aortic Valve Replacement

Conditions:   Aortic Stenosis;   Valvular Heart Disease;   Transcatheter Aortic Valve Replacement
Intervention:   Device: HUAWEI watch
Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University
Recruiting

Evaluating the Benefit of Concurrent Tricuspid Valve Repair During Mitral Surgery

Conditions:   Mild Tricuspid Regurgitation;   Moderate Tricuspid Regurgitation;   Tricuspid Regurgitation
Interventions:   Procedure: TV Annuloplasty;   Procedure: MVS
Sponsors:   Icahn School of Medicine at Mount Sinai;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research (CIHR);   German Society for Thoracic and Cardiovascular Surgery;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)
Active, not recruiting

Clinical Trial Evaluation of the Percutaneous 4Tech TriCinch Coil Tricuspid Valve Repair System

Condition:   Tricuspid Regurgitation
Intervention:   Device: TriCinch Coil System implantation
Sponsor:   4Tech Cardio Ltd.
Recruiting

Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Conditions:   Tricuspid Regurgitation;   Tricuspid Valve Insufficiency;   Tricuspid Valve Disease
Interventions:   Device: Edwards PASCAL System;   Drug: Optimal Medical Therapy
Sponsor:   Edwards Lifesciences
Recruiting

Personalized Treatments for Depressive Symptoms in Patients With Advanced Heart Failure

Conditions:   Depression;   Heart Failure
Interventions:   Behavioral: Behavioral Activation Therapy;   Drug: Medication Management
Sponsors:   Cedars-Sinai Medical Center;   Patient-Centered Outcomes Research Institute
Recruiting

Periprocedural Continuation Versus Interruption of Oral Anticoagulant Therapy and Protamine Use During Transcatheter Aortic Valve Implantation (POPular PAUSE TAVI)

Conditions:   Aortic Valve Disease;   Aortic Valve Stenosis;   Stroke;   Bleeding;   Vascular Complications;   Myocardial Infarction;   Thrombosis Embolism
Interventions:   Drug: Continuation of oral anticoagulants;   Drug: Interruption of oral anticoagulants
Sponsor:   St. Antonius Hospital
Not yet recruiting

REALIsM-HF Pilot Study

Condition:   Heart Failure
Interventions:   Device: VitalPatch Biosensor;   Device: DynaPort Move Monitor
Sponsor:   Bayer
Recruiting

THE TRAVEL TRIAL: Transcatheter Right Atrial-ventricular Valve rEplacement With LuX-Valve

Condition:   Tricuspid Valve Insufficiency
Intervention:   Device: Tricuspid Valve Replacement System
Sponsors:   Changhai Hospital;   Fu Wai Hospital, Beijing, China;   Beijing Anzhen Hospital;   Wuhan Union Hospital, China;   West China Hospital;   Xijing Hospital;   Guangdong Provincial People's Hospital
Recruiting

My Recordable On-Demand Audio Discharge Instructions

Condition:   Heart Failure, Congestive
Intervention:   Other: on-demand audio messages of heart failure education themes
Sponsors:   The Cleveland Clinic;   American Greetings
Active, not recruiting

RHEIA (Randomized researcH in womEn All Comers With Aortic Stenosis)

Conditions:   Aortic Valve Stenosis;   Heart Valve Diseases
Intervention:   Procedure: Transcatheter aortic valve replacement
Sponsors:   SSS International Clinical Research GmbH;   Edwards Lifesciences
Recruiting

The Efficacy and Safety of Pirfenidone in Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction

Condition:   Cardiac Failure
Interventions:   Drug: Pirfenidone;   Drug: Placebo
Sponsors:   Manchester University NHS Foundation Trust;   National Institute for Health Research, United Kingdom;   University of Manchester;   University of Liverpool, Clinical Trials Research Centre;   Hoffmann-La Roche
Completed

MitraClip EXPAND G4 Study

Conditions:   Mitral Valve Regurgitation;   Mitral Regurgitation
Intervention:   Device: MitraClip G4 System
Sponsors:   Abbott Medical Devices;   Abbott
Active, not recruiting