Cardiomyopathy

Clinical Trial Finder

Many patients with cardiomyopathy are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

A Phase 2 Open-label Pilot Study to Evaluate Efficacy, Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction

Condition:   Cardiomyopathy, Hypertrophic Obstructive
Intervention:   Drug: MYK-461
Sponsor:   MyoKardia, Inc.
Not yet recruiting - verified July 2016

A Study to Characterize the Cardiac Phenotype of Individuals With Friedreich's Ataxia (CARFA Study)

Condition:   Friedreich's Ataxia
Interventions:   Procedure: Cardiac magnetic resonance imaging (CMR);   Procedure: Exercise-stress test;   Procedure: Echocardiography (ECHO);   Procedure: Cardiac-related blood studies
Sponsors:   Annapurna Therapeutics;   Adverum Biotechnologies;   Weill Medical College of Cornell University
Recruiting - verified July 2016

Cognitive Behavioral Therapy for Insomnia in Stable Heart Failure

Conditions:   Heart Failure;   Insomnia;   Cardiomyopathy
Interventions:   Behavioral: Cognitive Behavioral Therapy for Insomnia (CBT-I);   Behavioral: Heart Failure Self-Management Education
Sponsor:   Yale University
Completed - verified July 2016

Employing End Tidal Capnography in Continuous Flow Ventricular Assist Device Patients

Conditions:   Cardiomyopathy;   Cardiovascular Disease;   Heart Disease
Interventions:   Device: Respiratory Depression Monitoring with End Tidal Carbon Dioxide Nasal Cannula (ETCO2- NC);   Other: Standard Non-invasive Respiratory Depression Monitoring
Sponsor:   Emory University
Recruiting - verified July 2016

Recovery of Hibernating Myocardium in End Stage Heart Failure

Conditions:   Myocardial Function After LVAD Implant;   Ischemic Cardiomyopathy
Intervention:  
Sponsors:   Intermountain Health Care, Inc.;   Intermountain Research and Medical Foundation
Recruiting - verified June 2016

Doxorubicin With Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma

Conditions:   Sarcoma, Soft Tissue;   Soft Tissue Sarcoma;   Undifferentiated Pleomorphic Sarcoma;   Leiomyosarcoma;   Liposarcoma;   Synovial Sarcoma;   Myxofibrosarcoma;   Angiosarcoma;   Fibrosarcoma;   Malignant Peripheral Nerve Sheath Tumor;   Epithelioid Sarcoma
Interventions:   Drug: Dexrazoxane;   Drug: Doxorubicin
Sponsor:   Washington University School of Medicine
Recruiting - verified July 2016

A Rollover Study of ARRY-371797 in Patients With LMNA-Related Dilated Cardiomyopathy

Condition:   LMNA-Related Dilated Cardiomyopathy
Intervention:   Drug: ARRY-371797, p38 inhibitor, oral
Sponsor:   Array BioPharma
Recruiting - verified July 2016

Rhode Island Diastolic Dysfunction - Heart Failure

Conditions:   Heart Failure;   Cardiovascular Disease
Intervention:   Drug: Kuvan
Sponsors:   Providence VA Medical Center;   BioMarin Pharmaceutical;   Lifespan
Recruiting - verified July 2016

Effect of Eleclazine (GS-6615) on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Interventions:   Drug: Eleclazine;   Drug: Placebo
Sponsor:   Gilead Sciences
Recruiting - verified July 2016

A Extension Study to Evaluate Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Cardiac Amyloidosis

Condition:   TTR-mediated Amyloidosis
Intervention:   Drug: Revusiran (ALN-TTRSC)
Sponsor:   Alnylam Pharmaceuticals
Active, not recruiting - verified July 2016

DISCOVERY: A Study Examining the Prevalence of TTR Mutations in Subjects Suspected of Having Cardiac Amyloidosis

Condition:   Familial Amyloidotic Cardiomyopathy (FAC)
Intervention:  
Sponsor:   Alnylam Pharmaceuticals
Completed - verified July 2016

Multicenter Automatic Defibrillator Implantation Trial - Chemotherapy-Induced Cardiomyopathy

Condition:   Cardiomyopathy
Intervention:   Device: Three-lead CRT-D (Defibrillator)
Sponsors:   University of Rochester;   Boston Scientific Corporation
Recruiting - verified July 2016

Safety and Efficacy of Tafamidis in Patients With Transthyretin Cardiomyopathy

Condition:   Transthyretin (TTR) Amyloid Cardiomyopathy
Interventions:   Drug: Tafamidis;   Drug: Tafamidis;   Drug: Placebo
Sponsor:   Pfizer
Active, not recruiting - verified July 2016

Study of Efficacy and Safety of Percutaneous Coronary Intervention to Improve Survival in Heart Failure

Condition:   Ischemic Cardiomyopathy
Interventions:   Procedure: Percutaneous Coronary Intervention;   Drug: Drug Therapy for Heart Failure;   Device: Device Therapy for Heart Failure
Sponsors:   King's College London;   National Institute for Health Research, United Kingdom;   London School of Hygiene and Tropical Medicine (Clinical Trials Unit);   University of York;   Guy's and St Thomas' NHS Foundation Trust
Recruiting - verified July 2016

Prospective Registry of Patients With Isolated Severe Tricuspid Regurgitation

Condition:   Tricuspid Regurgitation
Intervention:  
Sponsor:   Asan Medical Center
Recruiting - verified July 2016

PercutaneOus StEm Cell Injection Delivery Effects On Neomyogenesis in Dilated CardioMyopathy (The POSEIDON-DCM Study)

Condition:   Non-ischemic Dilated Cardiomyopathy
Interventions:   Procedure: Transendocardial injection;   Biological: Autologous hMSCs;   Biological: Allogeneic hMSCs
Sponsors:   Joshua M Hare;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified July 2016

ACAM2000® Myopericarditis Registry

Conditions:   Myocarditis;   Pericarditis
Intervention:  
Sponsor:   Sanofi Pasteur, a Sanofi Company
Active, not recruiting - verified July 2016

Transthyretin-Associated Amyloidoses Outcome Survey (THAOS)

Conditions:   Transthyretin Mutations;   Transthyretin Amyloidosis
Intervention:   Other: None. Observational Study.
Sponsor:   Pfizer
Recruiting - verified July 2016

Chagas Disease as an Undiagnosed Type of Cardiomyopathy in the United States

Conditions:   Heart Diseases;   Myocardial Diseases;   Chagas Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified November 2001

Enalapril After Anthracycline Cardiotoxicity

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Heart Failure;   Myocardial Diseases
Intervention:   Drug: enalapril
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified December 2005