Cardiomyopathy

Clinical Trial Finder

Many patients with cardiomyopathy are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Morbidity and Mortality in Patients With Hypertrophic Cardiomyopathy: a CALIBER Study

Condition:   Hypertrophic Cardiomyopathy
Intervention:   Other: No intervention
Sponsors:   University College, London;   Inherited Cardiac Diseases Unit, The Heart Hospital, London
Active, not recruiting - verified April 2015

T1 Mapping of Diffuse Myocardial Fibrosis in Congenital Heart Disease

Condition:   Cardiomyopathy
Intervention:   Other: Cardiac magnetic resonance sequence T1 mapping
Sponsor:   The Hospital for Sick Children
Recruiting - verified April 2015

A Phase 1/2 Study of High-dose Genetically Targeted Enzyme Replacement Therapy for Advanced Heart Failure

Conditions:   Ischemic Cardiomyopathy;   Non-ischemic Cardiomyopathy;   Heart Failure;   Cardiomyopathies
Interventions:   Genetic: MYDICAR Phase 1;   Genetic: MYDICAR Phase 2;   Genetic: Placebo Phase 2 only
Sponsor:   Celladon Corporation
Not yet recruiting - verified April 2015

ENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)

Condition:   Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)
Interventions:   Drug: Revusiran (ALN-TTRSC);   Drug: Sterile Normal Saline (0.9% NaCl)
Sponsor:   Alnylam Pharmaceuticals
Recruiting - verified April 2015

Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: New Insights Into the Pathophysiology

Conditions:   Syndrome X;   Takotsubo Cardiomyopathy
Intervention:   Other: BaroReflex Sensitivity, endothelial function measurement
Sponsor:   Ospedale San Giovanni Bellinzona
Active, not recruiting - verified April 2015

The Vital Amyloidosis Study, a Phase 3, Multicenter Efficacy and Safety Study of NEOD001

Condition:   Primary Systemic (AL) Amyloidosis
Interventions:   Drug: NEOD001;   Other: Placebo
Sponsor:   Prothena Therapeutics Ltd.
Active, not recruiting - verified April 2015

Characterization of the Cardiac Phenotype of Friedreich's Ataxia (FRDA)

Condition:   Friedreich's Ataxia
Interventions:   Procedure: Cardiac magnetic resonance imaging (CMR);   Procedure: Exercise-stress test;   Procedure: Echocardiogram (ECHO);   Procedure: Cardiac-related blood studies
Sponsor:   Weill Medical College of Cornell University
Recruiting - verified April 2015

A Extension Study to Evaluate Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Cardiac Amyloidosis

Condition:   TTR-mediated Amyloidosis
Intervention:   Drug: Revusiran (ALN-TTRSC)
Sponsor:   Alnylam Pharmaceuticals
Recruiting - verified April 2015

Using Ripple Mapping to Guide Substrate Ablation of Scar Related Ventricular Tachycardia.

Conditions:   Monomorphic Ventricular Tachycardia;   Myocardial Infarction;   Dilated Cardiomyopathy
Interventions:   Device: Ripple Mapping guided VT ablation;   Device: Conventional VT ablation
Sponsor:   Imperial College London
Recruiting - verified July 2014

Immunological Profile in Relation to Cardiac Geometry in Hypertension

Condition:   Immune System Profile During Hypertensive Cardiac Remodeling
Intervention:  
Sponsor:   Neuromed IRCCS
Recruiting - verified April 2015

Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Diastolic Cardiomyopathy (Aim3)

Conditions:   Cardiomyopathy;   Renal Impairment
Interventions:   Drug: Tadalafil;   Drug: Placebo
Sponsor:   Mayo Clinic
Recruiting - verified April 2015

Nitrate's Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction

Conditions:   Heart Failure;   Preserved Ejection Fraction
Interventions:   Drug: Isosorbide Mononitrate;   Drug: Placebo
Sponsor:   Duke University
Completed - verified April 2015

Open-Label, Dose-Escalating Study to Assess Safety, Tolerability, Efficacy, PK and PD of RP103 in Children With Inherited Mitochondrial Disease

Condition:   Inherited Mitochondrial Disease, Including Leigh Syndrome
Intervention:   Drug: Cysteamine Bitartrate Delayed-release Capsules (RP103)
Sponsor:   Raptor Pharmaceuticals Inc.
Recruiting - verified April 2015

Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Systolic Cardiomyopathy (Aim2)

Conditions:   Cardiomyopathy;   Renal Impairment
Interventions:   Drug: Tadalafil;   Drug: Placebo
Sponsor:   Mayo Clinic
Recruiting - verified April 2015

Intracoronary Autologous Mesenchymal Stem Cells Implantation in Patients With Ischemic Dilated Cardiomyopathy

Condition:   Ischemic Dilated Cardiomyopathy
Intervention:   Other: BM-MSCs
Sponsors:   National University of Malaysia;   Cytopeutics Sdn Bhd
Active, not recruiting - verified April 2015

Nebivolol for the Prevention of Left Ventricular Systolic Dysfunction in Patients With Duchenne Muscular Dystrophy

Conditions:   Duchenne Muscular Dystrophy;   Cardiomyopathy;   Heart Failure
Interventions:   Drug: Nebivolol;   Drug: Placebo
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Association Française contre les Myopathies (AFM), Paris
Recruiting - verified April 2015

CYCLosporinE A in Reperfused Acute Myocardial Infarction

Condition:   Acute Myocardial Infarction
Intervention:   Drug: Cyclosporine A
Sponsors:   Mario Negri Institute for Pharmacological Research;   Heart Care Foundation
Completed - verified October 2013

Burden of Disease Study In Patients With Transthyretin Familial Amyloidosis Polyneuropathy (TTR-FAP) orTransthyretin Cardiomyopathy (TTR-CM) And Caregivers

Conditions:   Transthyretin Familial Amyloidosis Polyneuropathy (TTR-FAP);   Transthyretin Cardiomyopathy (TTR-CM);   Familial Amyloid Cardiomyopathy;   Senile Systemic Amyloidosis (SSA)
Interventions:   Other: No drug;   Other: No drug
Sponsor:   Pfizer
Active, not recruiting - verified April 2015

Contribution Of Nuclear Magnetic Resonance Imaging In The Study Of Diabetic Cardiomyopathy

Conditions:   Diabetic;   Cardiomyopathy
Interventions:   Other: NUCLEAR MAGNETIC RESONANCE IMAGING;   Other: NUCLEAR MAGNETIC RESONANCE IMAGING
Sponsor:   Assistance Publique Hopitaux De Marseille
Recruiting - verified April 2015

ELEVATE Early LEvosimendan Vs Usual Care in Advanced Chronic hearT failurE

Condition:   Advanced Chronic Heart Failure
Interventions:   Drug: Diuretics;   Drug: Levosimendan
Sponsors:   Niguarda Hospital;   Orion Corporation, Orion Pharma
Recruiting - verified April 2015

Study of the Implantable Cardioverter Defibrillator (ICD) Intracardiac Electrograms

Conditions:   Congestive Heart Failure;   Sudden Cardiac Death;   Arrhythmia;   Cardiomyopathies
Intervention:  
Sponsors:   Johns Hopkins University;   Washington University School of Medicine
Completed - verified April 2015

Registry of Unexplained Cardiac Arrest

Conditions:   Cardiac Arrest;   Long QT Syndrome;   Brugada Syndrome;   Catecholaminergi Polymorphic Ventricular Tachycardia;   Idiopathic VentricularFibrillation;   Early Repolarization Syndrome;   Arrhythmogenic Right Ventricular Cardiomyopathy
Intervention:  
Sponsors:   University of British Columbia;   Heart and Stroke Foundation of Ontario;   Boston Scientific Corporation;   Medtronic
Recruiting - verified April 2015

Study to Compare TWA Test and EPS Test for Predicting Patients at Risk for Life-threatening Heart Rhythms (ABCD Study)

Conditions:   Ischemic Cardiomyopathy;   LV Dysfunction
Intervention:   Device: T-Wave Alternans test
Sponsors:   St. Jude Medical;   Cambridge Heart Inc.;   MetroHealth Medical Center
Completed - verified April 2015

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