Atrial Fibrillation Also called: AF, AFib

Clinical Trial Finder

Many patients with atrial fibrillation are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Circulating BDNF in Patients With Atrial Fibrillation Undergoing Catheter Ablation or Exercise Training

Condition:   Atrial Fibrillation
Interventions:   Procedure: Catheter ablation;   Behavioral: Exercise training
Sponsor:   Ottawa Heart Institute Research Corporation
Active, not recruiting

Radiofrequency Ablation of Atrial Fibrillation Under Apnea

Condition:   Atrial Fibrillation
Interventions:   Other: Periods of Apnea;   Other: Control Arm - No Periods of Apnea
Sponsors:   Weill Medical College of Cornell University;   Northwell Health;   The Methodist Hospital System
Not yet recruiting

Imaging-based, Non-invasive Diagnosis of Persistent Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Diagnostic Test: Electrocardiography, ecocardiography and MRI.
Sponsor:   County Clinical Emergency Hospital Cluj-Napoca
Suspended

Personalized Atrial Fibrillation Ablation With QDOT

Condition:   Atrial Fibrillation
Interventions:   Device: Atrial fibrillation ablation using the QDOT® catheter;   Procedure: Standard atrial fibrillation ablation
Sponsor:   Antonio Berruezo, MD, PhD
Not yet recruiting

Smartphone Electrocardiogram for Recording Atrial Fibrillation After a Cerebral Ischemic Event

Conditions:   Stroke;   Atrial Fibrillation
Intervention:   Device: Smartphone ECG
Sponsors:   Sarawak Heart Centre;   Ministry of Health, Malaysia
Recruiting

Non - Invasive Evaluation of the Left Atrium Anatomy and Function

Condition:   Atrial Fibrillation
Intervention:   Diagnostic Test: Echocardiography
Sponsor:   Universitair Ziekenhuis Brussel
Completed

Low Voltage-Directed Catheter Ablation for Atrial Fibrillation

Condition:   Atrial Fibrillation - Symptomatic
Intervention:   Procedure: Radiofrequency ablation
Sponsors:   Ohad Ziv;   Biosense Webster, Inc.
Recruiting

Thirty Day Heart Monitoring for Detection of Atrial Fibrillation Among Cryptogenic Stroke Patients

Condition:   Embolic Stroke of Undetermined Source
Intervention:  
Sponsors:   University of British Columbia;   Boehringer Ingelheim
Suspended

Persistent Atrial Fibrillation Ablation and Correlation to Quality of Life

Condition:   Atrial Fibrillation
Intervention:   Procedure: Reveal LINQ ILR implant before AF ablation
Sponsor:   Newmarket Electrophysiology Research Group Inc
Recruiting

Continuous Ambulatory ECG Monitoring for Detection of Postoperative Atrial Fibrillation Following Thoracic Surgery

Conditions:   Lung Cancer;   Atrial Fibrillation
Intervention:  
Sponsor:   University of Manitoba
Not yet recruiting

Hybrid Ablation Plus Medical Therapy for Persistent Atrial Fibrillation

Condition:   Persistent Atrial Fibrillation
Intervention:   Device: Insertable Cardiac Monitor
Sponsors:   University of Rochester;   Biotronik, Inc.
Not yet recruiting

Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Behavioral: standard care + moderate-intensity continuous exercise training;   Behavioral: standard care + high-intensity interval training
Sponsor:   Ottawa Heart Institute Research Corporation
Active, not recruiting

First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Persistent Atrial Fibrillation Treatment (RAAFT-3)

Condition:   Atrial Fibrillation
Interventions:   Drug: Anti Arrhythmics;   Procedure: Pulmonary Vein Isolation performed by Radio Frequency Catheter Ablation
Sponsors:   University of Pennsylvania;   Biosense Webster, Inc.;   Texas Cardiac Arrhythmia Research Foundation
Active, not recruiting

Epicardial Approach in Recurred Atrial Fibrillation

Condition:   Persistent Atrial Fibrillation
Interventions:   Procedure: hybrid approach;   Procedure: conventional endocardial approach
Sponsor:   Korea University Anam Hospital
Active, not recruiting

IDE Trial for Boston Scientific's Cryoballoon in the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Intervention:   Device: POLARx™ Cardiac Cryoablation System
Sponsor:   Boston Scientific Corporation
Not yet recruiting

Study of Major Cardiovascular Events in Patients With Nonvalvular Atrial Fibrillation Treated With Rivaroxaban

Condition:   Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

Botulinum Toxin Type A (AGN-151607) for the Prevention of Post-operative Atrial Fibrillation in Patients Undergoing Open-chest Cardiac Surgery (NOVA)

Condition:   Post-Operative Atrial Fibrillation
Interventions:   Drug: AGN-151607;   Drug: Placebo
Sponsor:   Allergan
Recruiting

Radiofrequency Ablation Versus Balloon Cryoablation in Elderly Patients With Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Procedure: radiofrequency ablation;   Procedure: ballon cryoablation
Sponsor:   Vivantes Netzwerk für Gesundheit GmbH
Recruiting

A Study to Investigate if Early Atrial Fibrillation (AF) Diagnosis Reduces Risk of Events Like Stroke in the Real-World

Condition:   Atrial Fibrillation
Interventions:   Device: Heart healthy Engagement Program with the Apple Watch Series 4 or later;   Device: Anti-Coagulation Adherence Module with the Apple Watch Series 5 or later
Sponsors:   Janssen Scientific Affairs, LLC;   Apple Inc.
Recruiting

The Effect of High-Intensity Interval Training on Glucose Variability and Atrial Fibrillation Symptoms

Conditions:   Atrial Fibrillation;   Type 2 Diabetes
Intervention:   Behavioral: High-intensity interval training + standard care
Sponsor:   Ottawa Heart Institute Research Corporation
Active, not recruiting

The HOLIDAY (HOw ALcohol InDuces Atrial TachYarrhythmias) Study

Conditions:   Atrial Fibrillation;   Alcohol
Interventions:   Drug: Ethanol;   Drug: Placebo
Sponsor:   University of California, San Francisco
Active, not recruiting

Risk of Stroke and Silent Cerebrovascular Thromboembolism After Cardioversion of Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Cardioversion;   Cerebrovascular Stroke
Interventions:   Procedure: Cardioversion;   Drug: Oral Anticoagulant
Sponsor:   Suleyman Demirel University
Active, not recruiting

Mineralocorticoid Antagonism to Stop Progression of Atrial Fibrillation (MONITOR-AF) Study

Condition:   Atrial Fibrillation
Interventions:   Drug: Spironolactone 25mg;   Drug: Placebo oral tablet
Sponsors:   National University Hospital, Singapore;   University of Otago
Recruiting

Study to Gather Information About the Safety of Oral Anticoagulation Drugs and How Well These Drugs Work in Real World for Patients With Non-valvular Atrial Fibrillation (Irregularly Heart Beats Which is Not Caused by a Heart Valve Problem)

Condition:   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto);   Drug: Apixaban;   Drug: Dabigatran;   Drug: Warfarin
Sponsors:   Bayer;   Janssen, LP
Active, not recruiting

Atrial Fibrillation Trial to Evade Recurrence: effectS of Hiit Before electrO-Cardioversion for 3-weeKs

Condition:   Persistent Atrial Fibrillation
Intervention:   Behavioral: High-intensity interval training
Sponsors:   Ottawa Heart Institute Research Corporation;   Cardiac Arrhythmia Network of Canada
Active, not recruiting

Sleep Apnea and Atrial Fibrillation Recurrence

Conditions:   Sleep Apnea Syndrome;   Atrial Fibrillation
Intervention:   Other: Intervention group
Sponsor:   Assistance Publique - Hôpitaux de Paris
Suspended

TIMING of Oral Anticoagulant Therapy in Acute Ischemic Stroke With Atrial Fibrillation

Conditions:   Ischemic Stroke;   Atrial Fibrillation
Interventions:   Other: Early start of NOAC;   Other: Late start of NOAC
Sponsors:   Uppsala University;   The Swedish Stroke Register (Riksstroke)
Recruiting

Study to Gather Information on the Kidney Function of Patients With Non-valvular Atrial Fibrillation (Irregularly Heart Beats Which is Not Caused by a Heart Valve Problem) Treated With Rivaroxaban or Vitamin K Antagonists

Condition:   Non-Valvular Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY-597939);   Drug: VKAs
Sponsors:   Bayer;   Janssen Research & Development, LLC
Not yet recruiting

Oral vs Intravenous Diltiazem for Rapid Atrial Fibrillation/Flutter Trial

Condition:   Atrial Fibrillation and Flutter
Interventions:   Drug: Diltiazem Oral Product;   Drug: Diltiazem Injectable Product
Sponsor:   Virginia Commonwealth University
Active, not recruiting

A Nationwide Observational Study Looking at Effectiveness and Bleeding Complications of NOACs vs. VKA in Non-valvular Atrial Fibrillation Patients.

Condition:   Non-valvular Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Apixaban (Eliquis);   Drug: Dabigatran etexilate (Pradaxa);   Drug: Warfarin (Marevan)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Terminated

Tooth Extraction in Patients With Atrial Fibrillation in Use of New Oral Anticoagulants

Conditions:   Atrial Fibrillation;   Periodontal Disease;   Hemorrhage
Interventions:   Drug: Rivaroxaban;   Drug: Dabigatran and Apixaban;   Drug: Warfarin
Sponsor:   University of Sao Paulo General Hospital
Active, not recruiting

Atrial Fibrillation Force Contact Ablation Study

Condition:   Paroxysmal Atrial Fibrillation
Intervention:  
Sponsor:   Lawson Health Research Institute
Completed

Effect of Targeted Education for Atrial Fibrillation Patients (Application Substudy)

Condition:   Atrial Fibrillation and Flutter
Intervention:   Other: Education
Sponsors:   University Hospital, Antwerp;   Bristol-Myers Squibb;   Universiteit Antwerpen
Recruiting

A Study to Determine if Identification of Undiagnosed Atrial Fibrillation in People at Least 70 Years of Age Reduces the Risk of Stroke

Conditions:   Atrial Fibrillation;   Atrial Flutter
Intervention:   Other: Zio®XT Monitor
Sponsors:   Bristol-Myers Squibb;   Pfizer
Recruiting

A Prospective Study to Examine the Need to Adjust the Dose of Apixaban When Used in Atrial Fibrillation and Obesity

Conditions:   Anticoagulant;   Apixaban;   Obesity
Intervention:   Diagnostic Test: Anti Xa levels
Sponsor:   HaEmek Medical Center, Israel
Completed

Clinical Investigation to Determine the Accuracy and Benefit of Cardioskin™ in Patients With Known Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:   Device: Wearing Cardioskin™ for 14 days
Sponsor:   Institut de Recherches Internationales Servier
Not yet recruiting

Italian Registry In the Setting of AF Ablation With Rivaroxaban (IRIS)

Condition:   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban;   Procedure: Catheter ablation
Sponsors:   Dr Carlo Lavalle;   Istituto Nazionale per le Ricerche Cardiovascolari (INRC)
Not yet recruiting

Meditation and Education That is Nurse Delivered for Symptom Management in PAF

Condition:   Paroxysmal Atrial Fibrillation
Interventions:   Behavioral: Meditation;   Other: AF Education;   Other: Phone Calls
Sponsor:   Stanford University
Recruiting

Sleep-disordered Breathing and Perioperative Atrial Fibrillation in Cardiac Surgery

Conditions:   Elective Coronary Artery Bypass Grafting (CABG) Surgery;   Coronary Artery Disease;   Sleep-disordered Breathing (SDB);   Atrial Fibrillation
Intervention:   Other: Stratification, no intervention
Sponsor:   Michael Arzt
Recruiting

Bariatric Atrial Restoration of Sinus Rhythm

Conditions:   Atrial Fibrillation;   Morbid Obesity
Interventions:   Procedure: Bariatric surgery;   Procedure: Atrial Fibrillation (AF) Catheter Ablation
Sponsor:   Stanford University
Recruiting

Esophageal Cooling for AF Ablation

Condition:   Atrial Fibrillation
Interventions:   Device: Esophageal Cooling;   Device: Control
Sponsors:   University of Pennsylvania;   Attune Medical
Suspended

Resynchronization/Defibrillation for Ambulatory Heart Failure Trial in Patients With Permanent Atrial Fibrillation

Conditions:   Heart Disease;   Congestive Heart Failure;   Atrial Fibrillation
Interventions:   Device: Optimal Medical therapy plus ICD;   Device: Optimal Medical therapy plus CRT/ICD
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting

Atrial Fibrillation After PFO Closure

Condition:   Stroke
Intervention:  
Sponsor:   University Hospital, Montpellier
Recruiting

This Study Observes the Usage of Non-vitamin K Antagonist Oral Anticoagulants (NOACs) in Elderly Patients With a Heart Rhythm Disorder in Spain

Condition:   Atrial Fibrillation
Intervention:   Drug: Non-vitamin K antagonist oral anticoagulant
Sponsor:   Boehringer Ingelheim
Suspended

Observe the Safety and Effectiveness of the WATCHMAN FLX™ for Subjects in Hong Kong

Condition:   Non-valvular Atrial Fibrillation
Intervention:   Device: The WATCHMAN FLX Delivery System
Sponsor:   Boston Scientific Corporation
Not yet recruiting

Evaluation of QDOT MICRO™ Catheter for Pulmonary Vein Isolation in Subjects With Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Intervention:   Device: RF Ablation with QDOT Micro
Sponsor:   Biosense Webster, Inc.
Active, not recruiting

Feasibility Study to Improve AF Outcomes Using a Digital Application for CV Risk Reduction

Condition:   Atrial Fibrillation
Interventions:   Device: AF CARE;   Behavioral: Usual Care
Sponsors:   Stanford University;   American Heart Association;   PatientBond
Recruiting

Early Administration of Edoxaban After Acute Ischemic Stroke in Patients With Non-valvular Atrial Fibrillation

Condition:   Acute Ischemic Stroke
Intervention:   Drug: Edoxaban
Sponsors:   Jong Sung Kim;   Kyung Hee University Hospital;   Soon Chun Hyang University;   Dong-A University Hospital
Recruiting

Assessment of the Utility of BIOMONITOR to Identify Atrial Fibrillation (AF) in Ablation Candidates Using Precise AF Detection

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Biotronik, Inc.
Active, not recruiting

Apple Heart Study: Assessment of Wristwatch-Based Photoplethysmography to Identify Cardiac Arrhythmias

Conditions:   Atrial Fibrillation;   Arrhythmias, Cardiac;   Atrial Flutter
Intervention:   Device: Apple Heart Study App
Sponsors:   Apple Inc.;   Stanford University
Completed

Radiofrequency (RF) Ablation for Atrial Fibrillation (AF) in Patients With Heart Failure With Preserved Ejection Fraction

Condition:   Heart Failure With Preserved Ejection Fraction
Intervention:   Procedure: RF ablation of AF using CARTO 3 and a Thermocool ST SF ablation catheter
Sponsors:   University of Rochester;   Biosense Webster, Inc.
Not yet recruiting

Transcutaneous Autonomic Modulation in Thoracic Surgery

Conditions:   Atrial Fibrillation, Postoperative;   Postoperative Complications;   Inflammation
Interventions:   Device: Transcutaneous Low-Level Vagal Nerve Stimulation (LLVNS);   Device: Sham LLVNS
Sponsor:   Duke University
Terminated

Triple or Dual Antithrombotic Therapy After PCI (TRIDUAL-PCI) Coronary Intervention in Patients With Non-valvular Atrial Fibrillation. Real-world Italian Multicenter Registry (TRIDUAL-PCI)

Conditions:   Atrial Fibrillation;   Myocardial Infarction;   Anticoagulant-induced Bleeding;   Coronary Disease
Intervention:   Drug: Antithrombotic Agent
Sponsor:   Scientific Institute San Raffaele
Recruiting

Optimal Antithrombotic Therapy for ACS Patients Concomitant AF Undergoing New Generation DES Implantation

Conditions:   Acute Coronary Syndrome (ACS);   Non-valvular Atrial Fibrillation (NVAF)
Interventions:   Drug: Triple antithrombotic therapy;   Drug: Dual antithrombotc therapy
Sponsor:   The First Affiliated Hospital with Nanjing Medical University
Recruiting

Russian National Registry of LAAO

Condition:   Atrial Fibrillation
Intervention:   Device: Catheter-based left atrial appendage occlusion
Sponsor:   National Research Center for Preventive Medicine
Completed

Pulsed Field Ablation to Irreversibly Electroporate Tissue and Treat AF

Condition:   Atrial Fibrillation
Intervention:   Device: Medtronic Pulsed Field Ablation (PFA) System
Sponsor:   Medtronic Cardiac Rhythm and Heart Failure
Recruiting

Empowerment and Mobile Technology in the Control of Cardiovascular Risk Factors in Patients With Ischemic Stroke

Conditions:   Ischemic Stroke;   Transient Ischemic Attack;   Atrial Fibrillation;   Hypertension;   Empowerment
Interventions:   Diagnostic Test: ECG monitoring for 3 weeks;   Other: Self-monitoring of BP and self-titration of antihypertensive medication
Sponsor:   Jukka Putaala
Recruiting

The Genomic Medicine at VA Study

Conditions:   Coronary Artery Disease;   Atrial Fibrillation;   Type 2 Diabetes;   Colorectal Cancer;   Breast Cancer;   Prostate Cancer
Intervention:   Diagnostic Test: Polygenic risk score (PRS)
Sponsors:   Harvard Medical School;   VA Boston Healthcare System
Not yet recruiting

Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

Conditions:   Intracerebral Hemorrhage;   Atrial Fibrillation
Interventions:   Drug: Apixaban;   Drug: Aspirin
Sponsors:   Yale University;   National Institute of Neurological Disorders and Stroke (NINDS)
Suspended

Prospective Record Of the Use of Dabigatran in Patients With Acute Stroke or TIA

Conditions:   Brain Ischemia With Non-valvular Atrial Fibrillation;   Transient Ischemic Attack With Non-valvular Atrial Fibrillation
Intervention:  
Sponsor:   University Hospital, Essen
Recruiting

This Study Looks at the Effects of Idarucizumab in Patients Who Take Dabigatran and Need Emergency Surgery or Are Bleeding

Condition:   Atrial Fibrillation
Intervention:   Drug: Idarucizumab
Sponsor:   Boehringer Ingelheim
Suspended

Omega-3 Fatty Acids in Elderly Patients With Acute Myocardial Infarction

Conditions:   Myocardial Infarction;   Heart Failure;   Myocardial Revascularization;   Atrial Fibrillation
Interventions:   Drug: Pikasol;   Other: Corn oil
Sponsors:   Oslo University Hospital;   University Hospital, Akershus;   Asker & Baerum Hospital;   Helse Stavanger HF
Active, not recruiting

Impact of Pharmacists' Training on Oral Anticoagulant Counseling

Conditions:   Deep Vein Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation
Intervention:   Behavioral: Counseling training
Sponsor:   University of Ibadan
Completed

A Genomic Approach to Warfarin Dose Prescription in Admixed Caribbean Hispanics

Conditions:   Atrial Fibrillation;   Deep Vein Thrombosis;   Cardiac Valvular Insufficiency;   Coagulopathies;   Pulmonary Embolism
Interventions:   Genetic: Genotype-guided;   Other: Standard-of-Care
Sponsors:   University of Puerto Rico;   National Institute on Minority Health and Health Disparities (NIMHD);   Genomas, Inc
Active, not recruiting

Risk Stratification Post TAVI Using TEG

Conditions:   Platelet Function Tests;   Predictive Value of Tests;   Thrombelastography;   Cardiovascular Diseases;   Aortic Valve Stenosis;   Thrombosis;   Transcatheter Aortic Valve Replacement
Intervention:  
Sponsor:   Torben Pottgiesser
Not yet recruiting

MAC Project, Monitoring of AntiCoagulant Therapies (MAC)

Condition:   Anticoagulants and Bleeding Disorders
Intervention:   Drug: Anticoagulant drugs
Sponsor:   Quovadis Associazione
Recruiting

Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome

Conditions:   Brain Infarction;   Ischemic Stroke;   Thrombosis;   Foramen Ovale, Patent
Intervention:  
Sponsors:   SECRETO Study Consortium;   Finnish Medical Foundation;   Helsinki University Central Hospital;   Academy of Finland;   Göteborg University
Recruiting

DOAC Versus VKA After Cardiac Surgery

Condition:   Anticoagulant-induced Bleeding
Interventions:   Drug: Warfarin;   Drug: Dabigatran;   Drug: Rivaroxaban;   Drug: Apixaban;   Drug: Edoxaban
Sponsor:   Laval University
Not yet recruiting

Arrhythmia Burden, Risk of Sudden Cardiac Death and Stroke in Patients With Fabry Disease

Condition:   Fabry Disease
Intervention:   Device: Implantable Loop Recorder
Sponsors:   University Hospital Birmingham NHS Foundation Trust;   Royal Free Hospital NHS Foundation Trust;   Salford Royal NHS Foundation Trust;   University of Sydney;   Cambridge University Hospitals NHS Foundation Trust
Recruiting

Prolonged Continuous ECG Monitoring Prior to Transcatheter Aortic Valve Implantation

Conditions:   Aortic Valve Stenosis;   Arrythmia
Intervention:   Device: ECG monitoring
Sponsor:   Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Active, not recruiting

Dexamethasone Compared to Conventional Therapy in the Treatment of Acute Pericarditis

Condition:   Pericarditis Acute
Interventions:   Drug: Dexamethasone therapy;   Drug: Conventional Therapy
Sponsor:   Rabin Medical Center
Not yet recruiting

The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial

Condition:   Coronary Artery Disease
Interventions:   Procedure: MICS CABG;   Procedure: Conventional CABG
Sponsors:   Ottawa Heart Institute Research Corporation;   London Health Sciences Centre;   Heart Center Leipzig - University Hospital;   Fortis Escorts Heart Institute;   The Methodist Hospital System;   Carolinas Medical Center;   Gundersen Lutheran Health System;   Jilin Heart Hospital;   Far Eastern Memorial Hospital;   Medtronic;   Apollo Hospitals;   Ichinomiya-Nishi Hospital;   Fresno Heart and Surgical Hospital
Active, not recruiting

Prospective European Multicenter Study on Aortic Valve Replacement: (E-AVR Registry)

Conditions:   Aortic Valve Stenosis;   Valve Heart Stenosis
Intervention:   Procedure: Aortic valve replacement
Sponsors:   University of Parma;   University of Genova;   University Hospitals, Leicester;   University of Hamburg;   San Camillo Hospital, Rome;   University of Turin, Italy;   Centre Hospitalier Universitaire de Besancon;   University Hospital, Udine, Italy;   Hospital Clinic of Barcelona;   University of Lausanne Hospitals;   Robert Debré Hospital;   Paracelsus Medical University;   University of Campania "Luigi Vanvitelli";   University of Texas, Southwestern Medical Center at Dallas;   Clinique Pasteur;   Cardiocentro Ticino;   Universita di Verona
Recruiting

First in Human Feasibility Study With ADAPT 3D - ALR for Aortic Leaflet Repair

Conditions:   Aortic Stenosis;   Aortic Insufficiency
Intervention:   Device: Implantation of ADAPT 3D ALR
Sponsors:   Admedus Regen Pty Ltd.;   Factory CRO for Medical Devices B.V.
Recruiting

Atrial Cardiomyopathy in Patients With Stroke of Undetected Mechanism

Condition:   Stroke
Intervention:  
Sponsors:   University Hospital Bispebjerg and Frederiksberg;   Rigshospitalet, Denmark;   Lundbeck Foundation
Recruiting

EnSite Precision Observational Study

Condition:   Cardiac Arrhythmia
Intervention:   Procedure: cardiac mapping and radiofrequency ablation procedure
Sponsor:   Abbott Medical Devices
Completed

Reducing Arrhythmia in Dialysis by Adjusting the Rx Electrolytes/Ultrafiltration, Study B

Condition:   End Stage Renal Disease
Interventions:   Other: UFR-restricted dialysis;   Other: UFR-unrestricted dialysis
Sponsors:   NYU Langone Health;   National Institutes of Health (NIH);   Duke University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

"Post-acute Pickwick Study" (Postacute-Pick-2020)

Conditions:   Acute on Chronic Hypercapnic Respiratory Failure;   Obesity Hypoventilation Syndrome (OHS)
Interventions:   Procedure: "Lifestyle modifications" group (Control);   Procedure: Automatic NIV;   Procedure: CPAP treatment group;   Procedure: NIV treatment groups
Sponsor:   Juan F. Masa
Not yet recruiting

Reducing Arrhythmia in Dialysis by Adjusting the Rx Electrolytes/Ultrafiltration, Study A

Condition:   End Stage Renal Disease
Interventions:   Other: Potassium Removal Maximization;   Other: Potassium Gradient Minimization;   Other: Alkalosis Avoidance;   Other: Acidosis avoidance
Sponsors:   NYU Langone Health;   National Heart, Lung, and Blood Institute (NHLBI);   Duke University;   National Institutes of Health (NIH)
Recruiting

Hypoglycaemia and Cardiac Arrhythmias in Type 2 Diabetes

Conditions:   Diabetes Mellitus, Type 2;   Arrhythmia, Cardiac
Interventions:   Other: Combined hyper- and hypoglycaemic clamp;   Device: Loop recorder (Reveal LINQ, Medtronic, Minneapolis, MN, USA);   Device: Continuous glucose monitoring (iPro2, Medtronic, Minneapolis, MN, USA)
Sponsor:   University Hospital, Gentofte, Copenhagen
Enrolling by invitation

Safety and Efficacy Study of Lotus Valve for Transcatheter Aortic Valve Replacement

Condition:   Aortic Stenosis
Interventions:   Device: Lotus Valve System;   Device: CoreValve/Evolut R Transcatheter Aortic Valve Replacement System;   Device: LOTUS Edge Valve System
Sponsor:   Boston Scientific Corporation
Recruiting

Optimal Timing of Transcatheter Aortic Valve Implantation and Percutaneous Coronary Intervention - The TAVI PCI Trial

Conditions:   Aortic Stenosis;   Coronary Artery Disease;   TAVI;   PCI
Interventions:   Procedure: PCI before TAVI;   Procedure: PCI after TAVI
Sponsor:   University of Zurich
Not yet recruiting

Efficacy and Safety of Allogeneic Mesenchymal Precursor Cells (Rexlemestrocel-L) for the Treatment of Heart Failure.

Condition:   Chronic Heart Failure
Interventions:   Biological: Allogeneic Mesenchymal Precursor Cells (MPC);   Other: Sham Comparator
Sponsor:   Mesoblast, Inc.
Active, not recruiting

Randomized Controlled Trial Between Auto-titration and Manual Titration of Non-invasive Ventilation in Obesity Hypoventilation Syndrome

Conditions:   Chronic Hypercapnic Respiratory Failure;   Obesity Hypoventilation Syndrome
Interventions:   Device: Manual Non invasive ventilation titration;   Device: Automatic Non invasive ventilation titration
Sponsor:   Sociedad Española de Neumología y Cirugía Torácica
Recruiting

ATrial Tachycardia PAcing Therapy in Congenital Heart

Conditions:   Atrial Arrhythmia;   Atrial Tachycardia;   Congenital Heart Disease;   Pacemaker Re-Entrant Tachycardia
Intervention:   Device: Medtronic
Sponsors:   Ian Law;   Memorial Healthcare System;   Children's Hospital of Michigan;   Indiana University Health;   Mayo Clinic;   Rainbow Babies and Children's Hospital;   The Hospital for Sick Children;   University of Wisconsin, Madison;   University of California, Los Angeles;   University of Utah;   Norton Healthcare;   University of Michigan;   Vanderbilt University Medical Center;   Children’s Hospital of Orange County
Recruiting