Atrial Fibrillation Also called: AF, AFib

Clinical Trial Finder

Many patients with atrial fibrillation are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Evaluation of the Detection of Atrial Fibrillation by a Wearable Dynamic ECG Recorder

Condition:   Atrial Fibrillation
Interventions:   Device: Wearable Dynamic ECG Recorder;   Device: 12-lead ECG recordings
Sponsor:   Huami Corporation
Recruiting

A Clinical Trial Screening for Atrial Fibrillation (AF-CATCH)

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   Shanghai Jiao Tong University School of Medicine
Active, not recruiting

aMAZE Study: LAA Ligation Adjunctive to PVI for Persistent or Longstanding Persistent Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Device: LARIAT + PVI;   Device: Pulmonary Vein Isolation
Sponsor:   AtriCure, Inc.
Active, not recruiting

This Study Uses the SITS Registry to Find Out When Patients With a Heart Rhythm Disorder (Atrial Fibrillation) Start Treatment With Dabigatran After They Had a Stroke

Condition:   Atrial Fibrillation
Intervention:   Drug: Dabigatran
Sponsors:   Boehringer Ingelheim;   SITS international registry, Karolinska University Hospital, Stockholm, Sweden
Completed

Intraoperative Amiodarone to Prevent Atrial Fibrillation in Lung Transplant Patients

Conditions:   Atrial Fibrillation;   Lung Transplant; Complications
Interventions:   Drug: Amiodarone with CoSeal;   Device: CO2 driver
Sponsor:   University of Louisville
Completed

Incidence of Post-operative Atrial Fibrillation Secondary to Abdominal Surgery

Conditions:   Atrial Fibrillation;   Surgery--Complications
Intervention:   Diagnostic Test: Holter monitoring
Sponsor:   Frederiksberg University Hospital
Recruiting

Hybrid Ablation Plus Medical Therapy for Persistent Atrial Fibrillation

Condition:   Persistent Atrial Fibrillation
Intervention:   Device: Insertable Cardiac Monitor
Sponsors:   University of Rochester;   Biotronik, Inc.
Recruiting

Randomized Evaluation of Decision Support Interventions for Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Other: Patient Decision Aid;   Other: Encounter Decision Aid
Sponsors:   University of Utah;   Mayo Clinic;   American Heart Association;   Patient-Centered Outcomes Research Institute
Not yet recruiting

Randomized Evaluation of Redo Ablation Procedures of Atrial Fibrillation With FIRM Guided Procedures

Conditions:   Persistent Atrial Fibrillation;   Paroxysmal Atrial Fibrillation
Interventions:   Procedure: Standard PVI;   Procedure: FIRM-Guided Procedure and PVI
Sponsor:   Abbott Medical Devices
Active, not recruiting

Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation With Heart Failure

Conditions:   Atrial Fibrillation;   Heart Failure;   Cryoballon Ablation
Intervention:   Procedure: Cryoballoon Pulmonary Vein Isolation
Sponsor:   St. Josefs-Hospital Wiesbaden GmbH
Recruiting

Boston Scientific's Cryoballoon in the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation

Condition:   Paroxysmal Atrial Fibrillation
Intervention:   Device: POLARx™ Cardiac Cryoablation System
Sponsor:   Boston Scientific Corporation
Recruiting

Study to Learn More About the Benefits and Side-effects of Drugs Rivaroxaban and Apixaban Compared to the Drug Warfarin for Stroke Prevention in Patients With Rapid and Irregular Heartbeat Which is Not Due to a Heart-valve Fault (Non-valvular Atrial Fibrillation) in the UK Routine Clinical Practice

Condition:   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Apixaban (Eliquis);   Drug: Warfarin
Sponsors:   Bayer;   Janssen, LP
Active, not recruiting

Study Aims to Collect Information in Routine Clinical Practice in Italy About the Number of Patients Suffering From Irregularly Heart Beats Which Are Not Caused by a Heart Valve Problem (Non-valvular Atrial Fibrillation, NVAF) Who Stopped or Changed Rivaroxaban Treatment

Condition:   Non-valvular Atrial Fibrillation
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting

A Study to Investigate if Early Atrial Fibrillation (AF) Diagnosis Reduces Risk of Events Like Stroke in the Real-World

Condition:   Atrial Fibrillation
Interventions:   Device: Heart healthy Engagement Program with the Apple Watch Series 4 or later;   Device: Anti-Coagulation Adherence Module with the Apple Watch Series 5 or later
Sponsors:   Janssen Scientific Affairs, LLC;   Apple Inc.
Recruiting

Early Treatment of Atrial Fibrillation for Stroke Prevention Trial

Conditions:   Atrial Fibrillation;   Stroke
Intervention:   Other: early standardised rhythm control
Sponsors:   Atrial Fibrillation Network;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK);   Sanofi;   Abbott;   Deutsche Herzstiftung e.V.
Completed

CLOSE Versus High Density Mapping Guided Catheter Ablation of Paroxysmal Atrial Fibrillation

Condition:   Pulmonary Vein Isolation
Interventions:   Procedure: Modified CLOSE protocol;   Procedure: High density mapping guided pulmonary vein isolation
Sponsor:   University Medical Centre Ljubljana
Not yet recruiting

Validation Study of the Watch HWA09 and Its Softwares ECG-SW1 and PPG-SW1 for the Detection of Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Arrythmia, Cardiac
Intervention:   Device: AF Detection
Sponsor:   Withings
Recruiting

Burden of Ischemic Stroke and Intake of Oral Anticoagulants in Patients With Atrial Fibrillation in the UK Primary Care

Condition:   Atrial Fibrillation
Intervention:   Drug: Oral anticoagulant
Sponsor:   Bayer
Active, not recruiting

Validation Study of WITHINGS BPM Core for the Detection of Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Arrhythmias, Cardiac;   Cardiovascular Diseases
Intervention:   Diagnostic Test: ECG measurement
Sponsor:   Withings
Recruiting

Inflammation, Fibrosis and Risk of Recurrence After Atrial Fibrillation Ablation

Conditions:   Atrial Fibrillation;   Atrial Inflammation
Interventions:   Diagnostic Test: Cardiac imaging tests;   Diagnostic Test: Venous blood samle collection
Sponsors:   Cardio Med Medical Center;   University of Targu Mures, Romania;   University Hospital of Targu Mures, Romania
Recruiting

Predictive Factors for Response to New Oral Anticoagulants in the Treatment of Non-valvular Atrial Fibrillation..

Condition:   Atrial Fibrillation
Interventions:   Drug: Apixaban;   Drug: Edoxaban;   Drug: Rivaroxaban;   Drug: Dabigatran
Sponsor:   Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Recruiting

Evaluation of Vein of Marshall Ethanol Infusion During Left Atrial Linear Ablation in Patients With Persistent Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Procedure: ALINE + VoM infusion;   Procedure: ALINE only
Sponsor:   AZ Sint-Jan AV
Recruiting

Study to Gather Information About the Safety of Oral Anticoagulation Drugs and How Well These Drugs Work in Real World for Patients With Non-valvular Atrial Fibrillation (Irregularly Heart Beats Which is Not Caused by a Heart Valve Problem)

Condition:   Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto);   Drug: Apixaban;   Drug: Dabigatran;   Drug: Warfarin
Sponsors:   Bayer;   Janssen, LP
Active, not recruiting

Reaching the Frail Elderly for the Management of Atrial Fibrillation

Condition:   Atrial Fibrillation
Intervention:  
Sponsor:   University Hospital Bispebjerg and Frederiksberg
Recruiting

Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

Conditions:   Atrial Fibrillation;   Stroke;   Bleeding
Interventions:   Drug: Antiplatelet-only strategy;   Drug: Oral Anticoagulant plus background antiplatelet therapy
Sponsors:   Icahn School of Medicine at Mount Sinai;   National Heart, Lung, and Blood Institute (NHLBI);   Vanderbilt University Medical Center
Recruiting

EdoxabaN or Warfarin Therapy In Device Procedures in Patients With Non-Valvular Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Drug: Edoxaban;   Drug: Warfarin
Sponsors:   Electrophysiology Research Foundation;   Axio Research Corporation
Terminated

Xarelto on Prevention of Stroke and Non-Central Nervous Systemic Embolism in Renally Impaired Korean Patients With Non-valvular Atrial Fibrillation

Condition:   Non-valvular Atrial Fibrillation (NVAF)
Intervention:   Drug: Rivaroxaban(Xarelto,BAY 59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting

Cardiovascular Registry of Atrial Fibrillation

Conditions:   Atrial Fibrillation;   Atrial Flutter
Intervention:   Other: Patient Registry Data
Sponsor:   Brazilian Clinical Research Institute
Not yet recruiting

Study to Gather Information on the Kidney Function of Patients With Non-valvular Atrial Fibrillation (Irregularly Heart Beats Which is Not Caused by a Heart Valve Problem) Treated With Rivaroxaban or Vitamin K Antagonists

Condition:   Non-Valvular Atrial Fibrillation
Interventions:   Drug: Rivaroxaban (Xarelto, BAY-597939);   Drug: VKAs
Sponsors:   Bayer;   Janssen Research & Development, LLC
Active, not recruiting

Optimal Anticoagulation for Higher Risk Patients Post-Catheter Ablation for Atrial Fibrillation Trial

Conditions:   Atrial Fibrillation;   Stroke
Interventions:   Drug: Rivaroxaban;   Drug: Acetylsalicylic acid
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research (CIHR);   Bayer;   Biotronik Canada Inc
Recruiting

RF Power, LSI and Oesophageal Temperature Alerts During AF Ablation (PiLOT-AF Study)

Condition:   Atrial Fibrillation
Interventions:   Procedure: Combination 1 of radiofrequency (RF) power and Lesion Size Index (LSI) on left atrial (LA) posterior wall;   Procedure: Combination 2 of radiofrequency (RF) power and Lesion Size Index (LSI) on left atrial (LA) posterior wall;   Procedure: Combination 3 of radiofrequency (RF) power and Lesion Size Index (LSI) on left atrial (LA) posterior wall;   Procedure: Combination 4 of radiofrequency (RF) power and Lesion Size Index (LSI) on left atrial (LA) posterior wall
Sponsor:   Oxford University Hospitals NHS Trust
Completed

Prospective Database for Prediction of Atrial Fibrillation in Pacemaker and ICD Patients

Conditions:   Atrial Fibrillation;   Pacemaker Ddd;   ICD
Intervention:   Diagnostic Test: 24 hour Holter ECG Monitoring
Sponsor:   Medical University of Graz
Recruiting

High-Density (HD) Wave Mapping in Subjects With Atrial Fibrillation as a Predictor of Recurrence After a Single Ablation Procedure Using a PVI-Only Strategy

Conditions:   Paroxysmal Atrial Fibrillation;   Persistent Atrial Fibrillation;   Cardiac Arrhythmia
Intervention:   Procedure: A specific electrophysiology mapping protocol is applicable with the GRID catheter.
Sponsor:   Abbott Medical Devices
Recruiting

Intensive Rhythm Monitoring to Decrease Ischemic Stroke and Systemic Embolism - the Find-AF 2 Study

Conditions:   Ischemic Stroke;   Atrial Fibrillation
Interventions:   Other: 7-day Holter ECG;   Other: Implantable cardiac monitor;   Other: Standard of care
Sponsors:   University of Leipzig;   Johannes Gutenberg University Mainz
Recruiting

A Study to Evaluate the Safety and Effectiveness of Rivaroxaban (Xarelto) for Prevention of Stroke and Systemic Embolism in Indian Patients With Non-valvular Atrial Fibrillation (NVAF)

Condition:   Non-valvular Atrial Fibrillation (NVAF)
Intervention:   Drug: Rivaroxaban (Xarelto,Bay 59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting

Early Versus Late Initiation of Direct Oral Anticoagulants in Post-ischaemic Stroke Patients With Atrial fibrillatioN (ELAN): an International, Multicentre, Randomised-controlled, Two-arm, Assessor-blinded Trial

Condition:   Ischaemic Stroke
Interventions:   Drug: Early treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®);   Drug: Late treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®)
Sponsor:   University Hospital Inselspital, Berne
Recruiting

Autoimmunity in the Pathogenesis of AF

Condition:   Atrial Fibrillation
Intervention:   Other: Peripheral Blood Sample
Sponsors:   Mayo Clinic;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

CLOSE to CURE Study

Condition:   Atrial Fibrillation
Intervention:   Procedure: Pulmonary vein isolation
Sponsor:   AZ Sint-Jan AV
Active, not recruiting

Comparison of LAA-Closure vs Oral Anticoagulation in Patients With NVAF and Status Post Intracranial Bleeding.

Conditions:   Atrial Fibrillation (AF);   Intracranial Bleed
Intervention:   Device: Percutaneous closure of the LAA (Watchman / Watchman FLX)
Sponsor:   Jena University Hospital
Recruiting

Left Atrial Appendage Occlusion Registry (LAAO Registry)

Condition:   Atrial Fibrillation
Intervention:   Procedure: Left Atrial Appendage Occlusion
Sponsor:   American College of Cardiology
Recruiting

Safety of Terminating the Prescription of Aspirin After Left Atrial Appendage Closure

Conditions:   Atrial Fibrillation;   Stroke;   Bleeding
Interventions:   Drug: Aspirin Tablet;   Drug: Placebo
Sponsor:   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Recruiting

Prospective Study to Validate Ablation Parameters With MRI Based Scar for Left Atrial Ablation

Condition:   Atrial Fibrillation
Interventions:   Device: AF Ablation;   Device: MRI
Sponsors:   Ravi Ranjan;   Biosense Webster, Inc.
Recruiting

POLARx Cardiac Cryoablation System Study

Condition:   Atrial Fibrillation
Intervention:   Device: Boston Scientific Cardiac Cryoablation System
Sponsor:   Boston Scientific Corporation
Not yet recruiting

Incidence of Silent Atrial Fibrillation in Patients With Clinically Silent Brain Ischemic Lesions

Conditions:   Silent Stroke;   Silent Cerebral Infarct;   Fibrillation
Intervention:  
Sponsor:   University Hospital Inselspital, Berne
Not yet recruiting

AMPLATZER™ Cardiac Plug Observational Post-Approval Study (ACP PAS China)

Condition:   Non-valvular Atrial Fibrillation (NVAF)
Intervention:   Device: AMPLATZER™ Cardiac Plug
Sponsor:   Abbott Medical Devices
Enrolling by invitation

AMPLATZER™ LAA Occluder Post Approval Study (PAS)

Conditions:   Atrial Fibrillation;   Thromboembolism;   Stroke
Intervention:   Device: AMPLATZER™ LAA Occluder
Sponsor:   Abbott Medical Devices
Recruiting

LSI (Lesion Index) Workflow Observational Study

Condition:   Paroxysmal Atrial Fibrillation
Intervention:   Device: Radiofrequency Ablation
Sponsor:   Abbott Medical Devices
Active, not recruiting

Pulsed Field Ablation to Irreversibly Electroporate Tissue and Treat AF

Condition:   Atrial Fibrillation
Intervention:   Device: Medtronic Pulsed Field Ablation (PFA) System
Sponsor:   Medtronic Cardiac Rhythm and Heart Failure
Recruiting

Amplatzer Amulet LAAO vs. NOAC

Conditions:   Atrial Fibrillation;   Stroke;   Bleeding
Interventions:   Device: Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder);   Drug: Non-Vitamin K Oral Antagonists
Sponsor:   Abbott Medical Devices
Not yet recruiting

Austrian Left Atrial Appendage Closure Registry

Conditions:   Atrial Fibrillation;   Left Atrial Appendage Closure
Intervention:   Device: LAAC
Sponsor:   Medical University of Graz
Recruiting

FIRE AND ICE II Trial Pilot

Conditions:   Persistent Atrial Fibrillation;   Atrial Arrhythmia
Interventions:   Device: Cryoballoon (Arctic Front Advance Cryoballoon);   Device: Radiofrequency Catheter (ThermoCool Smarttouch)
Sponsors:   Medtronic Cardiac Rhythm and Heart Failure;   genae associates (CRO), Antwerp, Belgium;   King's College London;   Deutsches Herzzentrum Muenchen
Recruiting

Ischemia Care Biomarkers of Acute Stroke Etiology (BASE)

Conditions:   Ischemic Stroke;   Atrial Fibrillation;   Transient Ischemic Attacks;   Transient Cerebrovascular Events;   Thrombotic Stroke;   Stroke of Basilar Artery;   Cardioembolic Stroke
Intervention:   Other: Biomarker blood draw
Sponsor:   Ischemia Care LLC
Completed

Study of DU-176b Aged 80 Years or Older

Condition:   Atrial Fibrillation
Interventions:   Drug: Du-176b;   Drug: placebo
Sponsor:   Daiichi Sankyo Co., Ltd.
Completed

Brain MRI in Stroke Patients With Intracardiac Thrombus

Conditions:   Stroke;   Intracardiac Thrombus
Intervention:   Other: No intervention,
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Recruiting

CLOSE-guided Pulmonary Vein Isolation Using High Power and Stable RF Applications

Condition:   Atrial Fibrillation
Interventions:   Procedure: High power CLOSE-guided PVI ablation;   Procedure: Standard CLOSE-guided PVI ablation
Sponsor:   AZ Sint-Jan AV
Completed

Watchman FLX Left Atrial Appendage Closure Device Post Approval Study ( Europe Only)

Condition:   Non-valvular Atrial Fibrillation
Intervention:   Device: Watchman FLX
Sponsors:   Boston Scientific Corporation;   Premier Research Group plc;   Iqvia Pty Ltd
Recruiting

Assessment of the WATCHMAN™ Device in Patients Unsuitable for Oral Anticoagulation

Condition:   Stroke
Interventions:   Device: WATCHMAN LAAC Device Implant;   Drug: Single Antiplatelet Therapy or No Therapy (Control)
Sponsor:   Boston Scientific Corporation
Recruiting

Study of Myocardial Deformation Parameters in Patients With Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Intervention:  
Sponsor:   AHEPA University Hospital
Active, not recruiting

Advisor HD Grid Observational Study

Conditions:   Persistent Atrial Fibrillation;   Ventricular Tachycardia
Intervention:   Device: Advisor HD Grid Mapping Catheter, Sensor Enabled
Sponsor:   Abbott Medical Devices
Active, not recruiting

Biomarkers of Acute Stroke in Clinic

Conditions:   Ischemic Stroke;   Ischemia;   Atrial Fibrillation;   Transient Ischemic Attack;   Transient Cerebrovascular Events;   Thrombotic Stroke;   Stroke;   Stroke, Acute;   Stroke, Ischemic;   Stroke, Complication;   Stroke of Basilar Artery;   Atherosclerosis;   Atheroma;   Cardioembolic Stroke;   Cardiomyopathies;   Cardiovascular Stroke;   Thromboembolism
Intervention:   Diagnostic Test: ISCDX blood test
Sponsor:   Ischemia Care LLC
Recruiting

I Can sEe Left Atrial Appendage (ICELAA) Clinical Study

Conditions:   Efficacy, Self;   Safety Issues
Intervention:   Device: intra-procedural intracardiac echocardiography
Sponsor:   Boston Scientific Corporation
Not yet recruiting

MidregiOn Proatrial Natriuretic Peptide to Guide SEconadry Stroke Prevention

Condition:   Stroke, Ischemic
Interventions:   Drug: Rivaroxaban;   Drug: Dabigatran;   Drug: Apixaban;   Drug: Edoxaban;   Drug: Aspirin;   Drug: Clopidogrel
Sponsor:   University of Zurich
Recruiting

ConfirmRxTM: Posture and Activity

Conditions:   Syncope;   Cryptogenic Stroke
Intervention:   Device: ConfirmRx (Insertable Cardiac Monitor)
Sponsor:   Abbott Medical Devices
Recruiting

Pharmacological Reduction of Right Ventricular Enlargement

Conditions:   Tricuspid Regurgitation;   Right Ventricular Dilatation
Interventions:   Drug: Carvedilol+Empagliflozin;   Drug: Carvedilol;   Drug: Empagliflozin;   Drug: Placebo
Sponsors:   Asan Medical Center;   Chong Kun Dang Pharmaceutical Company
Not yet recruiting

Gut Microbiome and Ventricular Arrhythmias

Conditions:   Ventricular Tachycardia;   Ventricular Fibrillation;   Gut Microbiome
Intervention:   Diagnostic Test: Stool test for microbial analysis
Sponsor:   North Florida Foundation for Research and Education
Not yet recruiting

Stress Test on the Prediction of Cardiovascular Events in a High-risk Firefighter Population

Conditions:   High Cardiovascular Risk;   Firefighter
Intervention:   Other: stress test
Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
Not yet recruiting

Moderato System in Patients With Hypertension

Conditions:   Hypertension, Resistant to Conventional Therapy;   Atrioventricular Block
Interventions:   Device: BackBeat Moderato System;   Device: BackBeat Moderato Sytsem
Sponsors:   BackBeat Medical Inc;   Massachusetts General Hospital;   MLM Medical Labs GmbH;   nabios GmbH
Active, not recruiting

TROPOnin FRAGMentation in Myocardial Injury Study

Conditions:   Acute Myocardial Infarction Type 1;   Myocardial Injury
Intervention:   Diagnostic Test: troponin T fragmentation test
Sponsor:   University of Turku
Recruiting

SMART Watch Facilitated Early Discharge in Patients Undergoing Transcatheter Aortic Valve Replacement

Conditions:   Aortic Stenosis;   Valvular Heart Disease;   Transcatheter Aortic Valve Replacement
Intervention:   Device: HUAWEI watch
Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University
Recruiting

Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry

Conditions:   Congestive Heart Failure;   Left Ventricular Systolic Dysfunction
Intervention:  
Sponsor:   ResMed
Completed

RHEIA (Randomized researcH in womEn All Comers With Aortic Stenosis)

Conditions:   Aortic Valve Stenosis;   Heart Valve Diseases
Intervention:   Procedure: Transcatheter aortic valve replacement
Sponsors:   SSS International Clinical Research GmbH;   Edwards Lifesciences
Recruiting

Evaluating the Benefit of Concurrent Tricuspid Valve Repair During Mitral Surgery

Conditions:   Mild Tricuspid Regurgitation;   Moderate Tricuspid Regurgitation;   Tricuspid Regurgitation
Interventions:   Procedure: TV Annuloplasty;   Procedure: MVS
Sponsors:   Icahn School of Medicine at Mount Sinai;   National Heart, Lung, and Blood Institute (NHLBI);   Canadian Institutes of Health Research (CIHR);   German Society for Thoracic and Cardiovascular Surgery;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)
Active, not recruiting

Aclidinium Bromide Post-Authorisation Safety Study to Evaluate the Risk of Cardiovascular Endpoints

Condition:   Pulmonary Disease, Chronic Obstructive
Interventions:   Drug: Aclidinium bromide;   Drug: Other COPD medication
Sponsors:   AstraZeneca;   RTI Health Solutions
Recruiting

Sodium Deposition in Soft Tissues of Patients With Kidney Disease

Condition:   Haemodialysis Complication
Intervention:   Other: Measuring sodium content
Sponsor:   Chris McIntyre
Recruiting

Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI).

Condition:   Severe Aortic Stenosis
Interventions:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI);   Procedure: Surgical Aortic Valve Replacement (SAVR);   Device: Medtronic CoreValve® Evolut R System Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting

Effects of SGLT2 Inhibitor on Type 2 Diabetic Patients Undergoing Cardiac Surgery

Conditions:   Diabetes Mellitus, Type 2;   Cardiac Surgery
Interventions:   Drug: Dapagliflozin 10 MG;   Drug: Placebos
Sponsor:   Hongchang Guo
Recruiting

Inhaled Sedation in COVID-19-related Acute Respiratory Distress Syndrome (ISCA): an International Research Data Study in the Recent Context of Widespread Disease Resulting From the 2019 (SARS-CoV2) Coronavirus Pandemics (COVID-19)

Conditions:   Critically Illness;   Sedation;   Invasive Mechanical Ventilation;   Acute Respiratory Distress Syndrome
Interventions:   Drug: Intravenous sedation;   Drug: Inhaled sedation
Sponsors:   University Hospital, Clermont-Ferrand;   Hospital Clínico Universitario de Valencia;   University of Schleswig-Holstein;   Groupe Hospitalier Pitie-Salpetriere
Recruiting

Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

Conditions:   Cardiac Arrest, Out-Of-Hospital;   Hypothermia, Induced;   Hypoxia-Ischemia, Brain
Intervention:   Device: Therapeutic Hypothermia
Sponsors:   University of Michigan;   Johns Hopkins University;   Medical University of South Carolina;   National Institutes of Health (NIH);   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting

Post Discharge After Surgery Virtual Care With Remote Automated Monitoring Technology (PVC-RAM) Trial

Conditions:   Surgery;   Perioperative Complication;   COVID
Intervention:   Other: Virtual Care and Remote Automated Monitoring
Sponsors:   Population Health Research Institute;   Hamilton Health Sciences Corporation;   McMaster University
Recruiting