Atherosclerosis

Clinical Trial Finder

Many patients with atherosclerosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Insulin Resistance and Atherosclerosis in Women With Lupus

Conditions:   Systemic Lupus Erythematosus;   Insulin Resistance;   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Completed

Genetic Factors in Atherosclerosis

Condition:   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Completed

Study to Gain Insights in Treatment Patterns and Outcomes in Patients With Atherosclerosis Prescribed to Xarelto in Combination With Acetylsalicylic Acid

Condition:   Atherosclerosis
Interventions:   Drug: Rivaroxaban (BAY59-7939, Xarelto);   Drug: Acetylsalicylic acid
Sponsors:   Bayer;   Janssen, LP
Recruiting

Hepatitis C Treatment and Atherosclerosis

Conditions:   Chronic Hepatitis C;   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Vascular Aging: The Link That Bridges Age to Atherosclerosis (The VALIDATE Study)

Conditions:   Atherosclerosis;   Cardiovascular Disease;   Vascular Diseases
Intervention:  
Sponsor:   National Institute on Aging (NIA)
Terminated

Study of Intracoronary CD34+ Cell Administration in Patients With Early Coronary Atherosclerosis

Condition:   Atherosclerosis, Coronary
Interventions:   Drug: Autologous CD34+ Cells;   Drug: Granulocyte Colony-Stimulating Factor (G-CSF)
Sponsor:   Mayo Clinic
Recruiting

Non-Invasive Assessment of Atherosclerosis in Patients With CGD and Other Disorders of the Immune System

Condition:   Chronic Granulomatous Disease (CGD)
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Active, not recruiting

Multi-Ethnic Study of Atherosclerosis (MESA)

Conditions:   Atherosclerosis;   Cardiovascular Diseases;   Heart Diseases;   Coronary Artery Disease;   Coronary Disease;   Stroke;   Myocardial Infarction;   Heart Failure;   Diabetes Mellitus, Type 2;   Hypertension;   Diabetes Mellitus
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

11C-PIB PET Study in MESA at Columbia University

Conditions:   Cognitive Impairment;   Vascular Diseases;   Alzheimer Disease;   Atherosclerosis
Intervention:   Drug: 11C-PIB
Sponsors:   José A. Luchsinger;   Wake Forest University;   National Institute on Aging (NIA)
Enrolling by invitation

Individualized Physical Activity and Carotid Plaque Instability

Condition:   Carotid Atherosclerosis
Interventions:   Device: individualized home-based physical activity;   Other: MRI;   Biological: blood sampling;   Other: Questionnaires;   Other: 6-minute walk test
Sponsor:   Hospices Civils de Lyon
Not yet recruiting

Visualization of Asymptomatic Atherosclerotic Disease for Optimum Cardiovascular Prevention

Condition:   Cardiovascular Diseases
Intervention:   Behavioral: Intervention
Sponsors:   Umeå University;   Västerbotten County Council, Sweden
Active, not recruiting

Cardiometabolic Risk Factors Registry

Conditions:   Atherosclerosis;   Metabolic Syndrome;   Diabetes;   Cardiovascular Risk Factor;   Cardiovascular Diseases;   Obesity
Intervention:  
Sponsor:   Austral University, Argentina
Recruiting

Identifying Vulnerable Plaques in Blood Vessels of the Heart Using a New Imaging Technique

Condition:   Coronary Arteriosclerosis
Intervention:   Device: OFDI imaging
Sponsors:   Massachusetts General Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation

Angiotensin-(1-7) in Peripheral Arterial Disease

Condition:   Peripheral Arterial Disease
Interventions:   Drug: Angiotensin 1-7;   Drug: Saline
Sponsor:   Milton S. Hershey Medical Center
Recruiting

Extracellular RNAs in Relation to Cardiometabolic Risk

Conditions:   Subclinical Atherosclerotic Cardiovascular Disease;   Blood Pressure;   Obesity
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation

CHIP/CCUS Natural History Protocol

Conditions:   Clonal Hematopoiesis of Indeterminate Potential;   Clonal Cytopenia of Undetermined Significance
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Functional Improvement of Coronary Artery Narrowing by Cholesterol Reduction With a PCSK9 Antibody

Conditions:   Coronary Artery Disease;   Atherosclerosis of Coronary Artery
Intervention:   Drug: Evolocumab 140 MG/ML [Repatha]
Sponsors:   Radboud University;   Amgen
Not yet recruiting

Vascular Effects of Alirocumab in Acute MI-Patients

Conditions:   Coronary Vessel;   Coronary Circulation;   Atheroma; Myocardial
Intervention:   Drug: Alirocumab
Sponsors:   University Hospital Inselspital, Berne;   Regeneron Pharmaceuticals
Recruiting

Treatment of Patients With Atherosclerotic Disease With Paclitaxel-associated to LDL Like Nanoparticles

Conditions:   Coronary Artery Disease;   Atherosclerosis;   Inflammation
Interventions:   Drug: LDE-Paclitaxel;   Drug: LDE-Placebo
Sponsor:   University of Sao Paulo General Hospital
Recruiting

Trial Comparing ELUVIA Versus Bare Metal Stent in Treatment of Superficial Femoral and/or Proximal Popliteal Artery

Conditions:   Arterial Occlusive Diseases;   Atherosclerosis;   Vascular Diseases;   Arteriosclerosis
Intervention:   Device: Peripheral stenting
Sponsor:   Boston Scientific Corporation
Recruiting

The Effect of E-EPA on Circulating LDL and Plasma Lipid Metabolism

Conditions:   Atherosclerosis;   Low-density Lipoproteins Aggregation Susceptibility;   Low-density Lipoprotein Lipid Composition;   Cardiovascular Diseases
Intervention:   Dietary Supplement: Ethyl-Eicosapentaenoic Acid (E-EPA)
Sponsors:   Wihuri Research Institute;   Helsinki University;   Karolinska Institutet;   Minerva Foundation Institute for Medical Research
Recruiting

Genetic Predictors of Cardiovascular Disease

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Completed

Registry Study to Evaluate the Performance and Safety of Roxwood Medical Catheters in Arteries of Participants With a Stenotic Lesion or Chronic Total Occlusion (CTO)

Conditions:   Chronic Total Occlusion;   Atherosclerosis;   Coronary Artery Disease;   Peripheral Artery Disease
Interventions:   Device: Roxwood Anchoring Catheters;   Drug: Acetylsalicylic Acid;   Drug: Heparin
Sponsor:   EKOS Corporation
Withdrawn

HCQ for the CVD in CKD

Conditions:   Chronic Kidney Disease;   Cardiovascular Disease;   Inflammation;   Atherosclerosis;   Aortic Stiffness
Interventions:   Procedure: MRI carotid;   Procedure: APWV;   Drug: Hydroxychloroquine;   Drug: Matching Placebo
Sponsor:   VA Office of Research and Development
Recruiting

Myocardial Inflammation in Rheumatoid Arthritis: A Descriptive Study

Conditions:   Myocardial Inflammation;   Rheumatoid Arthritis;   Coronary Artery Disease;   Myocardial Strain
Intervention:  
Sponsor:   Mayo Clinic
Recruiting

Pilot Study of Vitamin D Screening Use in Peripheral Arterial Disease Patient Over Maximum Distance Walking

Condition:   Peripheral Arterial Disease
Intervention:   Drug: Cholecalciferol
Sponsor:   University Hospital, Angers
Recruiting

Epidemiology of Venous Thrombosis and Pulmonary Embolism

Conditions:   Cardiovascular Diseases;   Pulmonary Embolism;   Venous Thrombosis
Intervention:  
Sponsors:   University of Minnesota;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Efficacy and Safety of Liraglutide in Type 2 Diabetes With Lower Extremity Arterial Disease

Conditions:   Type 2 Diabetes;   Peripheral Vascular Disorder Due to Diabetes Mellitus
Interventions:   Drug: Liraglutide+standard-of-care treatment;   Other: standard-of-care treatment
Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University
Not yet recruiting

Aging and Cognitive Health Evaluation in Elders (ACHIEVE)

Conditions:   Aging;   Cognitive Decline
Interventions:   Other: Successful aging education intervention;   Other: Hearing intervention
Sponsors:   Johns Hopkins Bloomberg School of Public Health;   University of North Carolina;   University of South Florida;   University of Pittsburgh;   University of Mississippi Medical Center;   Wake Forest University;   University of Minnesota
Active, not recruiting

Ruling Out Coronary Artery Disease and Myocardial Injury by Biomarkers

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   University Hospital, Akershus;   Haukeland University Hospital
Recruiting

Non-invasive Aortic Aneurysm Tissue Characterization Using Wall Viscoelasticity

Condition:   Abdominal Aortic Aneurysm Without Rupture
Intervention:   Device: Multiphase scan CT, non-invasive vascular ultrasound elastography by ultrasound (NIVE)
Sponsors:   Centre hospitalier de l'Université de Montréal (CHUM);   McGill University;   University of Calgary;   Eindhoven University of Technology
Not yet recruiting

Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins

Conditions:   Hypolipoproteinemia;   Hypercholesterolemia;   Dyslipidemia;   Hyperlipidemia
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Management of Anger in Patients With Acute Myocardial Infarction (MAPAMI)

Condition:   Myocardial Infarction
Intervention:   Behavioral: anger management training
Sponsor:   Instituto de Cardiologia do Rio Grande do Sul
Completed

Direct Intra-arterial Thrombectomy in Order to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals

Conditions:   Ischemic Stroke;   Large Vessel Occlusion;   Thrombectomy;   Thrombosis;   Alteplase
Interventions:   Procedure: intra-arterial thrombectomy;   Drug: Intravenous thrombolysis
Sponsors:   Changhai Hospital;   National Health and Family Planning Commission, P.R.China;   Wu Jieping Medical Foundation;   Cardiovascular Chinese Research Center;   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Completed

Study of Clinical Features and Genetics of Hyperimmunoglobulin E Recurrent Infection

Conditions:   Osteopenia;   Scoliosis;   Airway Disease;   Eczema;   Aneurysmal Coronary Artery Disease
Intervention:  
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Albert Einstein College of Medicine
Recruiting

Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese Women

Conditions:   Atherosclerosis;   Diabetes Mellitus;   Obesity;   Dyslipidemia;   Hypertension
Interventions:   Behavioral: Exercise;   Behavioral: Weight Loss
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

Conditions:   Cardiomyopathy;   Li-Fraumeni Syndrome;   Parkinson's Disease;   Atherosclerosis;   Cardiovascular Capacity
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Research on Aging Project in Iceland: Second Stage

Conditions:   Atherosclerosis;   Osteoporosis;   Obesity;   Glucose Abnormalities;   Alzheimer's Disease;   Vascular Dimentia
Intervention:  
Sponsor:   National Institute on Aging (NIA)
Completed

Study of the Disease Process of Lymphangioleiomyomatosis

Conditions:   Lung Disease;   Pneumothorax;   Tuberous Sclerosis;   Lymphangioleiomyomatosis
Intervention:   Device: Toshibia Aquilion One CT
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Effects of Renin-Angiotensin System Inhibitors in Peritoneal Dialysis Patients

Condition:   Peritoneal Dialysis
Intervention:   Drug: angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB)
Sponsor:   Chiang Mai University
Active, not recruiting

Reducing Cardiovascular Risk in Adults With Serious Mental Illness

Conditions:   Chronic Disease;   Mental Disorder;   Health Behavior;   Bipolar Disorder;   Schizophrenia
Intervention:   Behavioral: Prioritized Clinical Decision Support
Sponsors:   HealthPartners Institute;   Essentia Health;   National Institute of Mental Health (NIMH);   Park Nicollet Clinic
Completed

Phase 3 Study to Evaluate the Efficacy and Safety of LIB003 With Evolocumab in HoFH

Condition:   Homozygous Familial Hypercholesterolemia
Interventions:   Drug: LIB003;   Drug: evolocumab
Sponsor:   LIB Therapeutics LLC
Enrolling by invitation

Cilostazol and Nimodipine Combined Therapy After Aneurysmal Subarachnoid Hemorrhage (aSAH)

Condition:   Aneurysmal Subarachnoid Hemorrhage
Interventions:   Drug: Cilostazol 100 MG;   Other: Placebo
Sponsor:   Ascension South East Michigan
Recruiting

Predictors of AAA Expansion and/or Rupture

Condition:   Abdominal Aortic Aneurysm (AAA)
Interventions:   Drug: Assess AAA rupture risk by PET-CTA scans;   Drug: 18F-fludeoxyglucose (FDG);   Diagnostic Test: 11C-PBR28
Sponsor:   Washington University School of Medicine
Recruiting

Heparin-Binding Protein and Heparins

Conditions:   Vascular Disease, Peripheral;   Thromboprophylaxis;   Cardiovascular Diseases
Intervention:   Diagnostic Test: Blood samples for Heparin-binding protein measurement
Sponsors:   Halla Halldorsdottir;   Karolinska Institutet
Recruiting

The OPC for Optimal Delivery of Paclitaxel for the Prevention of Endovascular Restenosis - Above and Below the Knee

Conditions:   Peripheral Arterial Disease;   Cardiovascular Disease;   Peripheral Vascular Disease
Intervention:   Other: Paclitaxel administration using the OPC
Sponsors:   Horizons International Peripheral Group;   Advanced Catheter Therapies, Inc.
Completed

Performing a Low-dose, Whole-body Angiography as the First Element of an Imaging Assessment Following Stroke / TIA

Conditions:   Stroke;   Ischemic Attack, Transient
Interventions:   Other: Routine Imaging Assessment;   Device: LDWBA first (CT scan)
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Recruiting

Comparison of Cardiac Computed Tomography and Vasodilator Stress Magnetic Resonance Imaging Perfusion in Patients With Prior Equivocal Stress Test for Detection of Coronary Artery Disease

Conditions:   Myocardial Ischemia;   Coronary Artery Disease;   Myocardial Infarction
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Suspended

Identifying and Genotyping Homozygous Familial Hypercholesterolemia (HoFH) Patients

Condition:   Homozygous Familial Hypercholesterolemia (HoFH)
Intervention:  
Sponsor:   Regenxbio Inc.
Not yet recruiting

A Long-term Follow-up Study to Evaluate the Safety and Efficacy of RGX-501

Condition:   Homozygous Familial Hypercholesterolemia (HoFH)
Intervention:   Drug: Single intravenous (IV) dose of human Low Density Lipoprotein Receptor (LDLR) Gene Therapy
Sponsor:   Regenxbio Inc.
Enrolling by invitation

Clinical Studies of Progeria

Condition:   Progeria
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Completed

Actovegin 12-Week Treatment Given First Intravenously and Subsequently Orally in Participants With Peripheral Arterial Occlusive Disease Fontaine Stage IIB

Condition:   Peripheral Arterial Diseases
Interventions:   Drug: Actovegin;   Drug: Placebo
Sponsor:   Takeda
Completed

Cost-utility Analysis of the Outpatient Versus Conventional Hospitalization in Treatment of Occlusive Arterial Disease

Condition:   Peripheral Arterial Disease
Intervention:   Procedure: Treatment of Occlusive Arterial Disease
Sponsors:   Nantes University Hospital;   Ministry of Health, France
Completed

Ultrasound Evaluation of Lower Extremity Arteries After Topical Nitroglycerin Administration

Condition:   Peripheral Arterial Disease
Intervention:   Drug: Nitroglycerin Topical Product
Sponsor:   Deborah Heart and Lung Center
Not yet recruiting

TORUS 2 IDE Clinical Study

Condition:   Peripheral Arterial Disease
Intervention:   Device: TORUS Stent Graft System
Sponsors:   PQ Bypass, Inc.;   Syntactx
Recruiting

Post-Market Clinical Follow Up of Rotarex®S Catheter

Condition:   Peripheral Arterial Disease
Intervention:   Device: Atherectomy/Thrombectomy
Sponsor:   Straub Medical AG
Recruiting

TiVi Evaluation of Microcirculatory Reactivity of the Skin to Galvanic Stimulation: Effect of Aspirin

Condition:   Peripheral Arterial Disease
Intervention:   Device: TiVi system
Sponsor:   University Hospital, Angers
Recruiting

Evaluation of the GORE® VIABAHN® BALLOON EXPANDABLE ENDOPROSTHESIS (VIABAHN BX)

Conditions:   Common Iliac Artery Occlusive Disease;   External Iliac Artery Occlusive Disease;   Peripheral Arterial Disease
Intervention:   Device: Stenting of common and/or external iliacs
Sponsor:   W.L.Gore & Associates
Completed

In-Stent Restenosis Post-Approval Study

Conditions:   Peripheral Artery Disease;   Vascular Disease
Intervention:   Device: Gore VIABAHN Endoprosthesis
Sponsor:   W.L.Gore & Associates
Active, not recruiting

Evaluating Two Exercise Training Programs to Reduce Leg Pain in People With Peripheral Arterial Disease (The EXERT Study)

Conditions:   Intermittent Claudication;   Peripheral Vascular Diseases
Interventions:   Behavioral: Treadmill Exercise Training;   Behavioral: Arm Ergometry Exercise Training;   Behavioral: Usual Care
Sponsors:   University of Minnesota;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Using Smartphone Sensor Technology to Characterize Ambulatory Patterns of Participants With Peripheral Artery Disease

Condition:   Peripheral Artery Disease
Interventions:   Other: Accelerometry;   Other: Daynamica app
Sponsor:   University of Minnesota
Not yet recruiting

Dysvascular Amputation Self-Management of Health

Conditions:   Amputation;   Diabetes Mellitus;   Peripheral Artery Disease
Interventions:   Behavioral: Walking Biobehavioral Intervention;   Other: Attention Control
Sponsors:   University of Colorado, Denver;   National Institute of Nursing Research (NINR)
Recruiting

VIRTUOSE : Efficiency of Sildenafil on the Absolute Claudication Distance of Peripheral Arterial Disease Patients With Intermittent Claudication.

Condition:   Peripheral Artery Disease
Interventions:   Drug: Sildenafil;   Drug: Placebo
Sponsor:   Rennes University Hospital
Not yet recruiting

Cocoa to Improve Walking Performance in Peripheral Artery Disease

Condition:   Peripheral Artery Disease
Interventions:   Drug: Cocoa;   Drug: Placebo
Sponsors:   Northwestern University;   National Institute on Aging (NIA)
Completed

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Active, not recruiting

Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease

Conditions:   Peripheral Arterial Disease;   Diabetes Mellitus;   Critical Limb Ischemia
Intervention:   Diagnostic Test: SPECT/CT or PET/CT perfusion imaging
Sponsors:   Nationwide Children's Hospital;   Ohio State University
Recruiting

IN.PACT BTK Randomized Study to Assess Safety and Efficacy of IN.PACT 014 vs. PTA

Conditions:   Critical Limb Ischemia;   Peripheral Arterial Disease
Interventions:   Device: DCB;   Device: PTA
Sponsor:   Medtronic Endovascular
Active, not recruiting

FGF-1 for Intramuscular Injection for the Treatment of Peripheral Arterial Disease

Conditions:   Peripheral Arterial Disease;   Stenosis;   Intermittent Claudication
Interventions:   Drug: FGF-1;   Drug: Placebo
Sponsor:   CardioVascular BioTherapeutics, Inc.
Not yet recruiting

Lactate Increase in Peripheral Artery Disease

Conditions:   Peripheral Artery Disease;   Claudication, Intermittent
Intervention:   Diagnostic Test: Exercise oximetry
Sponsor:   University Hospital, Angers
Recruiting

Post-market, Prospective Evaluation of PHOTO-oxidized Bovine Pericardium in Vascular Surgery

Conditions:   Vascular Diseases;   Peripheral Arterial Disease;   Hemodialysis Access Failure (Disorder);   Carotid Artery Diseases;   Abdominal Aortic Aneurism
Intervention:   Device: PhotoFix
Sponsor:   CryoLife, Inc.
Recruiting

The Morehouse-Emory Cardiovascular Center for Health Equity Study: Clinical Intervention Project

Condition:   Cardiovascular Diseases
Interventions:   Behavioral: Health360x;   Behavioral: Health Coach
Sponsors:   Emory University;   American Heart Association
Active, not recruiting