Atherosclerosis

Clinical Trial Finder

Many patients with atherosclerosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

The Effects of Prolonged Standing Compared to Prolonged Sitting on Postprandial Lipemia

Conditions:   Metabolic Syndrome;   Atherosclerosis
Interventions:   Behavioral: Prolonged Standing;   Behavioral: Prolonged Sitting
Sponsor:   University of Texas at Austin
Not yet recruiting - verified March 2017

P Gingivalis Oral Infection, Intimamedia Thickening in Infants, Atherosclerosis

Condition:   Tooth Eruption, Atherosclerosis
Intervention:   Diagnostic Test: Ultrasound
Sponsor:   Creighton University
Not yet recruiting - verified March 2017

The LD Lync Study - Natural History Study of Genetic Lipodystrophy Syndromes

Condition:   Genetic Lipodystrophy
Intervention:  
Sponsor:   University of Michigan
Not yet recruiting - verified March 2017

Beijing Hospital Atherosclerosis Study

Conditions:   Atherosclerosis;   Cardiovascular Diseases;   Coronary Artery Disease;   Myocardial Ischemia;   Stroke
Intervention:  
Sponsor:   Beijing Hospital
Recruiting - verified March 2017

Effects of Different Protocols of Physical Training on Levels of Muscle Strength and Functional Capacity

Condition:   Peripheral Arterial Disease
Interventions:   Other: Electrical Stimulation;   Other: Strength training
Sponsor:   Hospital de Clinicas de Porto Alegre
Recruiting - verified March 2017

The Impact of Diabetes on REvascularization

Conditions:   Peripheral Arterial Disease;   Diabetes Mellitus
Interventions:   Diagnostic Test: Platelet function testing;   Diagnostic Test: Vascular ultrasonography
Sponsors:   Vanderbilt University Medical Center;   New England Research Institutes;   Massachusetts General Hospital
Not yet recruiting - verified March 2017

Effects of Fish Oil on Platelet Function and Coagulation

Conditions:   Platelet Aggregation, Spontaneous;   Atherosclerosis;   Surgery
Intervention:   Drug: Fish oil
Sponsor:   Region Skane
Enrolling by invitation - verified March 2017

High-resolution MRI of Inflammation in the Intracranial Arterial Vessel Wall

Condition:   Stroke
Intervention:   Drug: Ferumoxytol Injectable Product
Sponsors:   University of Utah;   AMAG Pharmaceuticals, Inc.
Not yet recruiting - verified March 2017

Multiple Ascending Doses of MEDI6012 in Subjects With Stable Atherosclerotic Cardiovascular Disease

Conditions:   Atherosclerosis;   Cardiovascular Disease
Interventions:   Biological: MEDI6012;   Biological: Placebo
Sponsor:   MedImmune LLC
Recruiting - verified March 2017

Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women

Conditions:   Estrogen Deficiency;   Cardiovascular Disease (CVD);   Hypothalamic Amenorrhea
Interventions:   Drug: 17beta Estradiol;   Drug: Transdermal placebo patch;   Drug: Progesterone;   Drug: Placebo Pill
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified March 2017

MGuard Stent and Microcirculation

Conditions:   Coronary Disease;   Coronary Artery Disease;   Coronary Atherosclerosis;   Cardiovascular Diseases
Interventions:   Device: MGuard stent;   Device: Drug eluting stent and bare metal stent
Sponsor:   University Hospital, Grenoble
Recruiting - verified February 2017

Dyslipidemia of Obesity Intervention in Teens

Conditions:   Dyslipidemia;   Obesity
Interventions:   Drug: Pitavastatin;   Drug: Placebo
Sponsors:   New England Research Institutes;   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified September 2016

Study to Evaluate the Effect of Nicotinamide Riboside on Immunity

Conditions:   Atherosclerosis;   Diabetes;   Coronary Artery Disease
Interventions:   Dietary Supplement: Nicotinamide riboside (NR);   Other: Placebo
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 15, 2017

Lutonix or Inpact for tHE tReatment Of fEmeropopliteal Stenosis - DCB

Condition:   Peripheral Arterial Disease
Interventions:   Device: Lutonix;   Device: IN.PACT
Sponsor:   Advocate Health Care
Recruiting - verified March 2017

Use of Indocyanine Green Angiography in Critical Limb Ischemia

Condition:   Peripheral Arterial Disease
Intervention:   Device: fluorescence angiography
Sponsor:   University Hospital, Grenoble
Recruiting - verified March 2017

Carotid Arteries Stenting Complications: Transradial Approach Versus Transfemoral

Conditions:   Carotid Atherosclerosis;   Carotid Stenosis;   Ischemic Attack;   Stroke;   Bleeding
Interventions:   Procedure: Transradial carotid artery stenting;   Procedure: Transfemoral carotid artery stenting
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Completed - verified March 2017

Safety and Effectiveness of Jetstream Atherectomy System (J-SUPREME)

Condition:   Peripheral Arterial Disease
Intervention:   Device: Jetstream Atherectomy System
Sponsor:   Boston Scientific Corporation
Active, not recruiting - verified March 2017

Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk (CLEAR Harmony)

Conditions:   Hypercholesterolemia;   Atherosclerotic Cardiovascular Diseases
Interventions:   Drug: ETC-1002;   Drug: Placebo
Sponsor:   Esperion Therapeutics
Active, not recruiting - verified March 2017

Sirolimus-eluting Stent CALYPSO vs Everolimus-eluting Stent XIENCE

Conditions:   Ischemic Heart Disease;   Coronary Atherosclerosis;   Coronary Artery Disease;   Coronary Artery Stenosis
Interventions:   Device: DES "Calypso";   Device: DES "Xience Prime";   Procedure: Coronary angioplasty
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Recruiting - verified March 2017

A Gene Therapy Study for Homozygous Familial Hypercholesterolemia (HoFH)

Condition:   Homozygous Familial Hypercholesterolemia
Intervention:   Biological: AAV directed hLDLR gene therapy
Sponsor:   University of Pennsylvania
Recruiting - verified March 2017

The Effect of Ticagrelor on 15-Epi-Lipoxin A4 and Inflammation

Condition:   Atherosclerosis
Interventions:   Drug: Clopidogrel;   Drug: Ticagrelor
Sponsor:   Baylor College of Medicine
Recruiting - verified March 2017

Beauty From Within Community Screening Project

Condition:   Heart Health Screening and Prevention
Interventions:   Procedure: Fingerstick cholesterol test;   Other: Atherosclerosis Cardiovascular Disease Risk assessment;   Procedure: Blood pressure measurement
Sponsor:   Cedars-Sinai Medical Center
Active, not recruiting - verified March 2017

Sitagliptin Effects on Arterial Vasculature and Inflammation in Obesity

Conditions:   Atherosclerosis;   Inflammation
Interventions:   Drug: Sitagliptin;   Drug: Placebo
Sponsor:   University of Southern California
Recruiting - verified March 2017

Vorapaxar as an Add-On Antiplatelet Therapy in Patients With and Without Diabetes Mellitus

Conditions:   Myocardial Infarction;   Diabetes Mellitus;   Peripheral Arterial Disease
Interventions:   Drug: Vorapaxar;   Drug: Clopidogrel;   Drug: Aspirin
Sponsors:   University of Florida;   Merck Sharp & Dohme Corp.
Recruiting - verified March 2017

L-Citrulline in Peripheral Artery Disease

Condition:   Peripheral Arterial Disease
Interventions:   Dietary Supplement: L-citrulline;   Dietary Supplement: Placebo
Sponsors:   Maastricht University;   Clinical Trial Center Maastricht;   Catharina Ziekenhuis Eindhoven;   Hannover Medical School
Recruiting - verified March 2017

Tack Optimized Balloon Angioplasty Study of the Tack Endovascular System™ in Femoropoliteal Arteries

Condition:   Peripheral Artery Disease
Intervention:   Device: Tack Endovascular System
Sponsor:   Intact Vascular
Active, not recruiting - verified March 2017

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Recruiting - verified March 2017

DANCE Partner: Inflammatory Biomarker Analysis by Femoropopliteal Revascularization Method and Treatment Outcomes

Condition:   Peripheral Arterial Disease
Interventions:   Device: Balloon Angioplasty;   Device: Atherectomy System
Sponsor:   Mercator MedSystems, Inc.
Active, not recruiting - verified March 2017

Prospective Evaluation of Carotid Free-floating Thrombus

Conditions:   Stroke;   Transient Ischemic Attack
Intervention:   Radiation: Computed Tomographic Angiogram
Sponsors:   Ottawa Hospital Research Institute;   The Ottawa Hospital
Recruiting - verified March 2017

Plaque Regression and Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen (PREMIER), Phase II

Condition:   Acute Coronary Artery Syndrome
Interventions:   Procedure: Percutaneous coronary intervention;   Procedure: Intravascular ultrasound with virtual histology;   Drug: Atorvastatin or other equivalent dose statin;   Device: LDL-apheresis
Sponsor:   VA Office of Research and Development
Recruiting - verified March 2017

Metformin in Kidney Disease

Conditions:   Chronic Kidney Disease;   Cardiovascular Disease;   Metabolic Syndrome
Interventions:   Drug: metformin;   Drug: Placebo
Sponsor:   VA Office of Research and Development
Recruiting - verified March 2017

Zilver® PTX® in China

Condition:   Peripheral Artery Disease
Intervention:   Device: Zilver® PTX® Drug-Eluting Peripheral Stent
Sponsor:   Cook
Completed - verified March 2017

Non-invasive Computer-Aided Phenotyping of Vasculopathy

Conditions:   Carotid Atherosclerosis;   Peripheral Arterial Disease
Intervention:  
Sponsor:   Elucid Bioimaging Inc.
Active, not recruiting - verified March 2017

Effectiveness of Adventitial Dexamethasone in Peripheral Artery Disease

Condition:   Peripheral Arterial Diseases
Intervention:   Drug: Dexamethasone Sodium Phosphate Injection, USP
Sponsor:   Mercator MedSystems, Inc.
Active, not recruiting - verified March 2017

Effects of Newly-Initiated QUAD Therapy on Aortic/Coronary Inflammation in ART-Naïve Infected Patients

Condition:   HIV
Intervention:  
Sponsors:   Massachusetts General Hospital;   Gilead Sciences
Completed - verified March 2017

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention &Amp; Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute;   Janssen Research & Development, LLC
Recruiting - verified March 2017

EverFlex Post Approval Study

Conditions:   Peripheral Arterial Disease;   Lower Extremity Arterial Disease
Intervention:   Device: EverFlex™ Self-Expanding Peripheral Stent System
Sponsor:   Medtronic Endovascular
Active, not recruiting - verified March 2017

Monitoring and Modifying Atherosclerosis in Psoriasis Patients Study

Condition:   Psoriasis
Intervention:  
Sponsors:   Massachusetts General Hospital;   Immunex Corporation
Terminated - verified March 2017

Caveolin-1 and Vascular Dysfunction

Conditions:   Hypertension;   Insulin Resistance
Interventions:   Drug: Para-aminohippuric Acid;   Drug: Angiotensin II;   Drug: Norepinephrine
Sponsors:   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI);   National Institutes of Health (NIH)
Active, not recruiting - verified March 2017

VISIBILITY™ Iliac Study

Conditions:   Peripheral Arterial Disease;   Claudication
Intervention:   Device: Visi-Pro™ Balloon Expandable Stent System
Sponsor:   Medtronic Endovascular
Completed - verified March 2017

DURABILITY™ Iliac Study

Conditions:   Peripheral Arterial Disease;   Claudication
Intervention:   Device: Protégé® EverFlex™ Self-Expanding Stent System, and Protégé® GPS™ Self-Expanding Stent System.
Sponsor:   Medtronic Endovascular
Completed - verified March 2017

REVEAL: Randomized EValuation of the Effects of Anacetrapib Through Lipid-modification

Condition:   Atherosclerotic Cardiovascular Disease
Interventions:   Drug: anacetrapib;   Drug: placebo anacetrapib
Sponsors:   University of Oxford;   Merck Sharp & Dohme Corp.
Active, not recruiting - verified March 2017

Exercise for Women With Peripheral Arterial Disease

Conditions:   Peripheral Artery Disease;   Claudication;   Women
Interventions:   Behavioral: Walking Exercise;   Behavioral: Control
Sponsors:   University of Oklahoma;   Oklahoma Center for the Advancement of Science and Technology
Completed - verified March 2017

Non-Invasive Assessment of Atherosclerosis in Patients With CGD and Other Disorders of the Immune System

Condition:   Chronic Granulomatous Disease (CGD)
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 10, 2017

The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Darapladib 160 mg;   Drug: Placebo;   Other: Standard Therapy
Sponsors:   GlaxoSmithKline;   The TIMI Study Group
Completed - verified March 2017

The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial

Condition:   Atherosclerosis
Interventions:   Drug: Darapladib;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Completed - verified March 2017

Reproductive Hormones And Pre-Clinical Cardiovascular Disease (CVD) In Women

Condition:   Heart Disease
Intervention:  
Sponsors:   Cedars-Sinai Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified March 2017

ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study

Conditions:   Cardiovascular Disease;   Coronary Artery Calcification
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting - verified March 9, 2017

EASEGO Study: Doubling of Atorvastatin/Simvastatin or INEGY in Patients With Hypercholesterolemia and Coronary Artery Disease(CAD)(0653A-089)

Condition:   Atherosclerosis
Interventions:   Drug: ezetimibe (+) simvastatin;   Drug: simvastatin;   Drug: atorvastatin
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified March 2017

Rosiglitazone Versus a Sulfonylurea On Progression Of Atherosclerosis In Patients With Heart Disease And Type 2 Diabetes

Condition:   Atherosclerosis
Interventions:   Drug: Glipizide;   Drug: rosiglitazone maleate
Sponsor:   GlaxoSmithKline
Completed - verified March 2017

Technical Development of Cardiovascular Magnetic Resonance Imaging

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 9, 2017

Correlates of Angiographic Changes and Coronary Events

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Coronary Arteriosclerosis;   Heart Diseases
Intervention:  
Sponsors:   University of Southern California;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified March 2017