Atherosclerosis

Clinical Trial Finder

Many patients with atherosclerosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

99mTc-rhAnnexin V-128 Imaging for Carotid Atherosclerosis

Condition:   Carotid Artery Plaque
Intervention:   Radiation: 99mTc-rhAnnexin V-128
Sponsor:   Advanced Accelerator Applications
Not yet recruiting - verified January 2016

Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk

Conditions:   Hypercholesterolemia;   Atherosclerotic Cardiovascular Diseases
Interventions:   Drug: ETC-1002;   Drug: Placebo
Sponsor:   Esperion Therapeutics
Recruiting - verified January 2016

The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9 Level After Coronary Bypass Surgery

Condition:   Coronary Artery Disease
Interventions:   Behavioral: resistance training;   Behavioral: aerobic training
Sponsor:   National Cardiovascular Center Harapan Kita Hospital Indonesia
Not yet recruiting - verified February 2016

HeartHab, Can a Patient-tailored Application Support Coronary Artery Disease Patients During Rehabilitation?

Condition:   Coronary Artery Disease
Intervention:   Behavioral: HeartHab application intervention
Sponsor:   Hasselt University
Not yet recruiting - verified January 2016

Influence of a Multi-parametric Optimization Strategy for General Anesthesia on Postoperative Morbidity and Mortality

Conditions:   Coronary; Ischemic;   Arrhythmias, Cardiac;   Heart Failure;   Peripheral Vascular Diseases;   Dementia;   Stroke;   Pulmonary Disease, Chronic Obstructive;   Respiratory Insufficiency;   Alcoholism;   Cancer;   Diabetes;   Renal Insufficiency
Interventions:   Procedure: OPTI-AGED;   Procedure: Usual Care
Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
Not yet recruiting - verified January 2016

Extracorporeal Cytokine Adsorption in Cardiac Surgery

Condition:   Cardiopulmonary Bypass
Interventions:   Device: CytoSorb;   Drug: Methylprednisolone
Sponsors:   University Medical Centre Ljubljana;   Slovenian Research Agency
Recruiting - verified January 2016

Does Co-registration of OCT and Angiography Reduce Geographic Miss of Stent Implantation?

Condition:   Coronary Artery Disease
Interventions:   Procedure: Coronary PCI with OCT with Co Registration;   Procedure: Coronary PCI with OCT without Co Registration
Sponsors:   St. Francis Hospital, New York;   CardioVascular Research Foundation, Korea
Not yet recruiting - verified January 2016

A Randomized, Pharmacodynamic Comparison of Low Dose Ticagrelor to Clopidogrel in Patients With Prior Myocardial Infarction

Conditions:   Myocardial Infarction;   Diabetes Mellitus;   Renal Disease;   Coronary Artery Disease
Interventions:   Drug: Ticagrelor;   Drug: Clopidogrel
Sponsors:   University of Patras;   AstraZeneca
Not yet recruiting - verified January 2016

Prospective Evaluation of Prognosis of Pci Patients Using Network Data in SHengjing Hospital

Condition:   Coronary Heart Disease
Intervention:   Procedure: PCI
Sponsor:   Shengjing Hospital
Not yet recruiting - verified January 2016

Retrospective Evaluation of Prognosis of Pci Patients Using Network Data in SHengjing Hospital

Condition:   Coronary Heart Disease
Intervention:   Procedure: PCI
Sponsor:   Shengjing Hospital
Recruiting - verified January 2016

Reshaping the Path of Vascular Cognitive Impairment (VCI)

Conditions:   Transient Ischemic Attack;   Vascular Cognitive Impairment;   Subcortical Vascular Dementia
Interventions:   Behavioral: Resistance exercise training;   Behavioral: Control: stretching and relaxation program
Sponsor:   University of British Columbia
Not yet recruiting - verified January 2016

Remote Ischaemic Conditioning and Coronary Endothelial Function (RIC-COR)

Conditions:   Ischemic Preconditioning;   Coronary Disease
Interventions:   Procedure: Remote ischaemic conditioning;   Procedure: Arm cuff placement, no inflation;
Sponsors:   NHS National Waiting Times Centre Board;   University of Glasgow
Enrolling by invitation - verified January 2016

GLP-1 and Hyperoxia for Organ Protection in Heart Surgery

Conditions:   Coronary Disease;   Shock, Cardiogenic;   Renal Failure;   Stroke;   Brain Injury;   Aortic Valve Disease
Interventions:   Drug: Byetta (Lilly, Exenatide);   Drug: Conoxia (AGA, oxygen);   Drug: 20% Human Albumin
Sponsor:   Rigshospitalet, Denmark
Not yet recruiting - verified February 2016

EVOLVE Short DAPT Study

Condition:   Coronary Artery Disease
Interventions:   Drug: 3 months of dual antiplatelet therapy (DAPT);   Device: SYNERGY Stent System
Sponsor:   Boston Scientific Corporation
Recruiting - verified January 2016

Vericiguat Drug-drug Interaction With Nitroglycerin in Stable Coronary Artery Disease Patients

Condition:   Coronary Artery Disease
Interventions:   Drug: Vericiguat (BAY1021189);   Drug: Placebo;   Drug: Nitroglycerin
Sponsors:   Bayer;   Merck Sharp & Dohme Corp.
Recruiting - verified January 2016

Assessment of Catheter-based Interrogation and Standard Techniques for Fractional Flow Reserve Measurement

Condition:   Coronary Artery Disease
Interventions:   Device: RXi System;   Device: Pressure Wire
Sponsor:   Acist Medical Systems
Recruiting - verified November 2015

The Relationship Between HHcy and Contrast-induced Nephropathy in Hypertensive Patients After Coronary Artery Diagnosis and Treatment

Conditions:   Homocysteine;   Coronary Disease;   Angioplasty,Balloon,Coronary;   Contrast Media;   Nephropathy;   Hypertension
Interventions:   Drug: Enalapril Maleate Tablets(as the program-based antihypertension);   Drug: Enalapril Maleate and Folic Acid tablets(as the program-based antihypertension);   Drug: Placebo
Sponsor:   Fuling Central Hospital of Chongqing City
Recruiting - verified February 2016

A phase3 Study Measuring the Effect of Rosuvastatin 20 mg on Carotid Intima-Media Thickness in Chinese Subjects With Subclinical Atherosclerosis

Condition:   Atherosclerosis
Interventions:   Drug: Rosuvastatin;   Drug: Placebo
Sponsor:   AstraZeneca
Recruiting - verified February 2016

Predischarge Bundle to Minimize Negative Impact on Quality of Life of Nuisance Bleedings

Conditions:   Myocardial Ischemia;   Hemorrhage;   Quality of Life;   Platelet Aggregation Inhibitors
Interventions:   Behavioral: good clinical practice;   Behavioral: bundle group
Sponsor:   University Hospital of Ferrara
Recruiting - verified January 2016

Optilene® Suture for Coronary Artery Bypass Graft Surgery

Conditions:   Coronary Heart Disease;   Multi Vessel Coronary Artery Disease
Intervention:   Procedure: Coronary Artery Bypass Graft surgery
Sponsors:   Aesculap AG;   B.Braun Surgical SA
Recruiting - verified January 2016

ComparisoN of ticAgrelor vs. Clopidogrel in endoTHeliAl Function of COPD patieNts

Conditions:   Coronary Artery Disease;   Chronic Obstructive Pulmonary Disease
Interventions:   Drug: Aspirin 100 mg;   Drug: Ticagrelor;   Drug: Clopidogrel
Sponsor:   University Hospital of Ferrara
Recruiting - verified January 2016

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Recruiting - verified February 2016

York Study of Unloading Shoes for Vascular Intermittent Claudication

Conditions:   Intermittent Claudication;   Peripheral Arterial Disease
Interventions:   Device: Unloading shoes;   Device: Unadapted control shoe
Sponsors:   York Teaching Hospitals NHS Foundation Trust;   University of York;   York St John University;   University of Salford
Recruiting - verified January 2016

CER-001 Atherosclerosis Regression ACS Trial

Condition:   Acute Coronary Syndromes
Interventions:   Drug: CER-001;   Drug: Placebo
Sponsors:   Cerenis Therapeutics, SA;   South Australian Health and Medical Research Institute
Recruiting - verified January 2016

Oral Nutritional Supplement in Reducing Surgical Site Infections

Conditions:   Peripheral Vascular Disease;   Claudication
Intervention:   Dietary Supplement: Arginine enriched oral nutritional supplement
Sponsors:   University of Limerick;   UL Hospitals, Limerick
Recruiting - verified February 2016

BAC in Patient With Alzheimer's Disease or Vascular Dementia

Conditions:   Alzheimer's Disease;   Vascular Dementia
Interventions:   Drug: BAC;   Other: BAC Matched Vehicle
Sponsors:   Charsire Biotechnology Corp.;   A2 Healthcare Taiwan Corporation
Not yet recruiting - verified January 2016

Acute Vascular Response to Exercise in Women With Nonobstructive Coronary Artery Disease

Condition:   Nonobstructive Coronary Artery Disease
Intervention:   Other: Slow-paced walking
Sponsor:   University of Florida
Recruiting - verified February 2016

Sitagliptin in Non-Diabetic Patients Undergoing Cardiac Surgery

Condition:   Coronary Artery Disease
Interventions:   Drug: Sitagliptin;   Drug: Placebo;   Drug: Regular Human Insulin;   Drug: Insulin glargine;   Drug: Supplemental insulin (Insulin lispro);   Drug: Supplemental insulin (Insulin aspart)
Sponsor:   Emory University
Recruiting - verified January 2016

Metformin and Corus CAD

Condition:   Coronary Artery Disease
Intervention:   Other: Corus CAD
Sponsor:   CardioDx
Completed - verified January 2016

a Physician-inititated Trial Investigating the iVolution Nitinol Stent

Condition:   Peripheral Arterial Disease
Intervention:   Device: iVolution nitinol stent
Sponsor:   Flanders Medical Research Program
Recruiting - verified February 2016

Medtronic Resolute Onyx Core (2.25 mm - 4.0 mm) Clinical Study

Condition:   Coronary Artery Disease
Intervention:   Device: Resolute Onyx Stent - 2.25 mm - 4.0 mm
Sponsor:   Medtronic Vascular
Active, not recruiting - verified January 2016

A Study on the Use of CorMatrix ®ECM® for Femoral Arterial Reconstruction

Condition:   Peripheral Vascular Disease
Intervention:   Device: CorMatrix ECM for Vascular Repair
Sponsor:   CorMatrix
Enrolling by invitation - verified January 2016

A Study to Obtain Additional Information on the Use of CorMatrix® CanGaroo ECM® Envelope

Condition:   Coronary Disease
Intervention:   Device: CorMatrix CanGaroo ECM Envelope
Sponsor:   CorMatrix
Withdrawn - verified January 2016

Comparison of Prevena Negative Pressure Incision Management System vs. Standard Dressing After Vascular Surgery

Conditions:   Peripheral Artery Disease;   Critical Limb Ischemia;   Claudication
Interventions:   Other: standard gauze dressing;   Other: Prevena Incision Management system
Sponsors:   University of Vermont Medical Center;   KCI USA, Inc.;   Maine Medical Center;   Brigham and Women's Hospital;   Beth Israel Deaconess Medical Center
Recruiting - verified February 2016

DEFINITIVE AR Two Year Follow-up Extension Study

Condition:   Peripheral Arterial Disease
Intervention:  
Sponsor:   Medtronic Endovascular
Completed - verified January 2016

Long-term Exercise in Older Cardiac Patients

Condition:   Coronary Artery Disease
Interventions:   Behavioral: SystemCHANGE;   Behavioral: CHANGE+;   Behavioral: Usual Care
Sponsor:   Case Western Reserve University
Completed - verified January 2016

Italian Absorb Registry

Condition:   Coronary Artery Disease
Intervention:   Device: PCI with Absorb scaffold
Sponsors:   Ospedale Santa Croce-Carle Cuneo;   Fatebenefratelli and Ophthalmic Hospital;   Bolognini Hospital;   Ospedale Regionale di Aosta;   Ospedali Riuniti di Ancona;   S. Giacomo Hospital;   Azienda U.L.S.S n.9 Ospedale di Treviso Ca Foncello;   Ospedale San Bortolo di Vicenza;   Azienda Ospedaliera Brotzu;   San Giuseppe Moscati Hospital;   Azienda Sanitaria Locale USL 13 Ospedale Mazzoni di Ascoli Piceno;   S. Andrea Hospital;   Ospedale Monaldi di Napoli;   Azienda Ospedaliera di Padova;   Ospedale della Misericordia di Grosseto;   Ospedale Santa Corona di Pietra Ligure;   Istituto di Ricerche Farmacologiche Mario Negri Milano
Active, not recruiting - verified February 2016

BIOLUX P-III All-Comers Passeo-18 Lux Registry

Conditions:   Atherosclerosis;   Peripheral Artery Disease
Intervention:   Device: Passeo-18 Lux
Sponsor:   Biotronik AG
Recruiting - verified January 2016

Peripheral Arterial Insufficiency Associated With HIV/AIDS

Conditions:   Arterial Insufficiency;   Acquired Immunodeficiency Syndrome;   HIV
Intervention:   Procedure: Ankle-Brachial index
Sponsor:   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Completed - verified January 2016

"Preventing Cardiovascular Ischemic Events and Arresting Their Consequences in Type 2 Diabetic Population

Conditions:   Type 2 Diabetes.;   Microangiopathy;   Non Alcoholic Fatty Liver Disease;   Coronary Artery Disease;   Cerebrovascular Disease;   Acute Coronary Syndrome/ Miocardial Infarction;   Ictus
Intervention:  
Sponsor:   Hospital Universitari Vall d'Hebron Research Institute
Recruiting - verified January 2016

New Technologies to Determine Carotid Plaque Vulnerability

Conditions:   Atherosclerosis;   Carotid Artery Plaque
Intervention:  
Sponsors:   Mayo Clinic;   GE Healthcare
Recruiting - verified January 2016

Off Pump Versus On Pump Coronary Artery Bypass Grafting in Frailty Patients (FRAGILE)

Conditions:   Coronary Artery Disease;   Complications Due to Coronary Artery Bypass Graft;   Fragility
Interventions:   Procedure: OPCAB;   Procedure: CABG
Sponsors:   University of Sao Paulo General Hospital;   InCor Heart Institute;   Cardiac Emergency Hospital of Pernambuco;   Alberto Urquiza Wanderley Hospital of João Pessoa;   Pitangueiras Hospital of Jundiaí;   University of Campinas, Brazil;   Cardiology Institute of the Distrito Federal;   National Cardiology Institute;   Federal University of São Paulo;   Pontifícia Universidade Católica do Paraná;   Clinical Hospital Samuel Libânio of Pouso Alegre;   Beneficência Portuguesa of São Paulo;   Pontifical University Catholic of Campinas;   InCor Heart Institute of Natal
Not yet recruiting - verified January 2016

Prognostic Value of SPECT-imaging Myocardial Perfusion Heterogeneity

Conditions:   Coronary Artery Disease;   Coronary Atherosclerosis
Intervention:   Device: Stress Single Photon Emission Computed Tomography
Sponsor:   University Hospital, Grenoble
Recruiting - verified January 2016

Physician-Initiated Trial Investigating the BeGraft Peripheral Stent Graft System

Condition:   Peripheral Vascular Disease
Intervention:   Device: BeGraft Peripheral Stent Graft System
Sponsor:   Flanders Medical Research Program
Active, not recruiting - verified February 2016

TurboHawk™ Japan Trial

Condition:   Peripheral Arterial Disease
Intervention:   Device: TurboHawk™ LS-C, TurboHawk™ LX-C ,TurboHawk™ SS-C, TurboHawk™ SS-CL and TurboHawk™ SX-C
Sponsor:   Medtronic Endovascular
Active, not recruiting - verified January 2016

The IN.PACT SFA Clinical Study for the Treatment of Atherosclerotic Lesions in the Superficial Femoral Artery and/or Proximal Popliteal Artery Using the IN.PACT Admiral™ Drug-Eluting Balloon in a Chinese Patient Population

Condition:   Atherosclerosis
Intervention:   Device: IN.PACT Admiral Paclitaxel-Eluting Percutaneous Transluminal Angioplasty (PTA) Balloon Catheter
Sponsor:   Medtronic Endovascular
Active, not recruiting - verified January 2016

The Effect of Cranberry Extract Supplementation on Cardiovascular Risk Factors in Obese, Insulin Resistant Humans

Conditions:   Insulin Resistance;   Atherosclerosis
Interventions:   Dietary Supplement: Cranberry Extract;   Other: Placebo
Sponsors:   Pennington Biomedical Research Center;   Ocean Spray, Inc.
Recruiting - verified February 2016

Aortic Valve and Root Measurements Under Real-Time 3-Dimensional Visualization During Angiography

Conditions:   Coronary Artery Disease;   Aortic Stenosis
Intervention:   Radiation: Real-time 3-dimensional DynaCT
Sponsor:   Binita Shah
Recruiting - verified January 2016

Phase III Study Comparing Two Methods of Cardioplegia in Aortic Valve Surgery Custodiol-N Versus Custodiol

Conditions:   Aortic Valve Disease;   Coronary Artery Disease (CAD)
Interventions:   Drug: Custodiol-N;   Drug: Custodiol
Sponsor:   Dr. F. Köhler Chemie GmbH
Recruiting - verified January 2016

The Effect of Heat on Blood and Oxygen Flow Readings Part 2

Conditions:   Healthy;   Peripheral Vascular Disease;   Vasoconstriction
Interventions:   Other: Specialized pulse oximetry probe with external heat pack;   Other: Standard of Care Pulse Oximetry Probe
Sponsors:   VA Pittsburgh Healthcare System;   Medline Industries
Completed - verified February 2016

Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Hyperlipidemia or Mixed Dyslipidemia at Risk of Cardiovascular Events

Condition:   Hyperlipidemia
Interventions:   Drug: Bococizumab (PF-04950615; RN316);   Other: Placebo
Sponsor:   Pfizer
Recruiting - verified January 2016

Post-Market CorPath Registry on the CorPath 200 System in Percutaneous Coronary Interventions

Conditions:   Coronary Artery Disease;   Coronary Disease;   Myocardial Ischemia;   Heart Diseases;   Cardiovascular Diseases;   Arteriosclerosis;   Arterial Occlusive Diseases;   Vascular Diseases
Intervention:   Procedure: CorPath-assisted Percutaneous Coronary Intervention
Sponsor:   Corindus Inc.
Recruiting - verified January 2016

A Clinical Evaluation of Absorb™ Bioresorbable Vascular Scaffold (Absorb™ BVS) System in Chinese Population ~ ABSORB CHINA Randomized Controlled Trial (RCT)

Conditions:   Coronary Artery Disease;   Coronary Artery Stenosis;   Coronary Disease;   Coronary Stenosis
Interventions:   Device: XIENCE V EECSS;   Device: ABSORB BVS System
Sponsor:   Abbott Vascular
Active, not recruiting - verified January 2016

Gadobutrol/Gadavist-enhanced Cardiac Magnetic Resonance Imaging (CMRI) to Detect Coronary Artery Disease (CAD)

Condition:   Coronary Artery Disease
Intervention:   Drug: Gadobutrol (Gadovist, BAY86-4875)
Sponsor:   Bayer
Active, not recruiting - verified February 2016

Gadobutrol / Gadavist-enhanced Cardiac Magnetic Resonance Imaging (CMRI) to Detect Coronary Artery Disease (CAD)

Condition:   Coronary Artery Disease
Intervention:   Drug: Gadobutrol (Gadovist, BAY86-4875)
Sponsor:   Bayer
Recruiting - verified February 2016

Indocyanine Green Fluorescence Uptake in Human Carotid Artery Plaque

Conditions:   Atherosclerosis;   Atherosclerotic Plaque;   Carotid Stenosis
Intervention:   Drug: Indocyanine green
Sponsor:   Massachusetts General Hospital
Completed - verified February 2016

A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure

Conditions:   Heart Failure;   Coronary Artery Disease
Interventions:   Drug: Rivaroxaban;   Drug: Placebo;   Other: Standard of care for heart failure and coronary artery disease
Sponsors:   Janssen Research & Development, LLC;   Bayer
Recruiting - verified January 2016

OPtical Frequency Domain Imaging Versus INtravascular Ultrasound in Percutaneous Coronary InterventiON - OPINION Imaging

Condition:   Coronary Artery Disease
Interventions:   Device: OFDI-guided PCI & IVUS;   Device: IVUS-guided PCI & OFDI
Sponsors:   Translational Research Informatics Center, Kobe, Hyogo, Japan;   Wakayama Medical University
Active, not recruiting - verified February 2016

Observational Study to Evaluate PAD Treatment Clinical and Economic Outcomes

Condition:   Peripheral Arterial Occlusive Disease
Intervention:   Other: PAD endovascular treatments
Sponsor:   Cardiovascular Systems Inc
Active, not recruiting - verified December 2015

RAdiation Dose In percutAneuos Coronary Procedures Through TransradIal apprOach Using Dedicated radiatioN Shields

Condition:   Myocardial Ischemia
Interventions:   Procedure: Coronary angiography;   Procedure: PCI;   Procedure: Right approach;   Procedure: Left approach
Sponsor:   Ospedale Sandro Pertini, Roma
Completed - verified January 2016

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention & Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute
Recruiting - verified February 2016

Clopidogrel Response Evaluation and AnTi-Platelet InterVEntion in High Thrombotic Risk PCI Patients

Condition:   Coronary Heart Disease
Interventions:   Drug: Clopidogrel 75mg;   Drug: Clopidogrel 150mg;   Drug: Aspirin 100mg;   Drug: Cilostazol 100mg
Sponsors:   Chinese Academy of Medical Sciences, Fuwai Hospital;   Beijing Municipal Health Bureau;   Haemonetics Corporation;   Zhejiang Otsuka Pharmaceutical Co., Ltd.
Active, not recruiting - verified August 2015

Comparison of Double Kissing Culotte Stenting With Double Kissing Crush Stenting for True Bifurcation Lesions

Condition:   Coronary Heart Disease
Intervention:   Device: Resolute stents
Sponsors:   Fujian Medical University;   Jetmed(Beijing)Co.,Ltd.
Recruiting - verified February 2016

Optical Frequency Domain Imaging (OFDI) and Vascular Healing After Stent Placement Diabetics Presenting With Acute Coronary Syndrome

Condition:   Coronary Artery Disease
Intervention:   Device: Resolute Integrity stent
Sponsor:   Emory University
Active, not recruiting - verified February 2016

Randomized Trial of Coronary Angioplasty for de Novo Lesions in sMall vesSElS With Drug Eluting Balloon.

Condition:   Coronary Disease
Interventions:   Device: Drug elluting Balloon (DEB);   Device: Drug elluting coronary stent (DES)
Sponsors:   Andres Iñiguez Romo, MD, PhD;   Hospital de Meixoeiro
Recruiting - verified January 2016

EverFlex Post Approval Study

Conditions:   Peripheral Arterial Disease;   Lower Extremity Arterial Disease
Intervention:   Device: EverFlex™ Self-Expanding Peripheral Stent System
Sponsor:   Medtronic Endovascular
Recruiting - verified January 2016

Safety and Efficacy of Allogeneic Cells for the Treatment of Intermittent Claudication(IC)

Conditions:   Intermittent Claudication;   Peripheral Artery Disease
Interventions:   Biological: PLX-PAD Low dose;   Biological: PLX-PAD high doses;   Biological: Double Placebo;   Biological: high dose +Placebo
Sponsor:   Pluristem Ltd.
Recruiting - verified February 2016

A Study to Evaluate the Effect of Aleglitazar on Cardiac Energetics and Function in Patients With Type 2 Diabetes Mellitus and no History of Coronary Artery Disease

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: aleglitazar;   Drug: placebo
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

A Registry to Evaluate Patterns of Care Associated With the Use of Corus® CAD in Real World Clinical Care Settings

Conditions:   Chest Pain;   Coronary Artery Disease
Intervention:  
Sponsor:   CardioDx
Completed - verified January 2016

Improvement of Endothelial Function by EGCG

Condition:   Cardiovascular Diseases
Interventions:   Dietary Supplement: Green tea beverage;   Dietary Supplement: Green tea extract;   Dietary Supplement: EGCG;   Other: Placebo
Sponsor:   Charite University, Berlin, Germany
Completed - verified February 2016

Safety and Feasibility of the Zotarolimus Stent in Treating Males With Erectile Dysfunction (ED)

Conditions:   Erectile Dysfunction;   Atherosclerosis
Intervention:   Device: Zotarolimus-Eluting Peripheral Stent System
Sponsor:   Medtronic Endovascular
Terminated - verified January 2016

IN.PACT Global Clinical Study

Condition:   Peripheral Arterial Disease
Intervention:   Device: IN.PACT Admiral™ Drug Eluting Balloon
Sponsor:   Medtronic Endovascular
Active, not recruiting - verified January 2016

A Phase II Study of the Safety and Efficacy of MPSK3169A in Patients With Coronary Heart Disease or High Risk of Coronary Heart Disease

Condition:   Coronary Heart Disease
Interventions:   Drug: MPSK3169A;   Drug: MPSK3169A;   Drug: MPSK3169A;   Drug: MPSK3169A;   Drug: MPSK3169A;   Drug: Placebo
Sponsor:   Genentech, Inc.
Completed - verified February 2016

Coronary Artery Bypass Grafting Strategies for the Anterolateral Territory: a Prospective Randomized Clinical Trial

Condition:   Coronary Artery Disease
Interventions:   Procedure: LIMA to SVG Bridge Technique;   Procedure: Conventional CABG
Sponsors:   Centre hospitalier de l'Université de Montréal (CHUM);   Canadian Institutes of Health Research (CIHR)
Recruiting - verified January 2016

Efficacy and Safety of Ad5FGF-4 for Myocardial Ischemia in Patients With Stable Angina Due to Coronary Artery Disease

Condition:   Angina, Stable
Intervention:   Genetic: Alferminogene tadenovec
Sponsors:   Cardium Therapeutics;   Advanced Biosciences Research
Active, not recruiting - verified January 2016

A Study of Dalcetrapib in Patients With Stable Coronary Heart Disease, With Coronary Heart Disease Risk Equivalents or at Elevated Risk for Cardiovascular Disease

Condition:   Cardiovascular Disease, Coronary Heart Disease, Dyslipidemia, Peripheral Arterial Disease (PAD)
Interventions:   Other: Background care;   Drug: Placebo;   Drug: dalcetrapib
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

ESPRIT I: A Clinical Evaluation of the Abbott Vascular ESPRIT BVS (Bioresorbable Vascular Scaffold) System

Conditions:   Atherosclerosis;   Peripheral Vascular Disease;   Claudication
Intervention:   Device: ESPRIT BVS
Sponsor:   Abbott Vascular
Completed - verified January 2016

International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Coronary Artery Disease;   Heart Diseases;   Myocardial Ischemia
Interventions:   Procedure: cardiac catheterization;   Procedure: coronary artery bypass graft surgery;   Procedure: percutaneous coronary intervention;   Behavioral: Lifestyle;   Drug: Medication
Sponsors:   New York University School of Medicine;   New York University;   Stanford University;   National Heart, Lung, and Blood Institute (NHLBI);   Albany Stratton VA Medical Center;   Cedars-Sinai Medical Center;   Columbia University;   Duke University;   East Carolina University;   Emory University;   Harvard University;   Massachusetts General Hospital;   Montreal Heart Institute;   University of British Columbia;   University of Missouri, Kansas City;   Vanderbilt University
Recruiting - verified January 2016

Paclitaxel Eluting Stent in Long SFA Obstruction: A Prospective, Randomized Comparison With Bypass Surgery

Conditions:   Chronic Lower Limb Ischemia;   Peripheral Athero Obstructive Disease;   Critical Ischemia;   Claudication
Interventions:   Procedure: bypass surgery, stent placement;   Procedure: stent placement
Sponsors:   Kuopio University Hospital;   Helsinki University Central Hospital;   Turku University Hospital;   Tampere University Hospital;   Oulu University Hospital;   Finnish Society of Interventional radiology;   North Karelia Central Hospital;   Paijat-Hame Hospital District
Recruiting - verified October 2015

The Role Of Noninvasive 320-Row Multidetector Computer Tomography

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   University Health Network, Toronto;   Mount Sinai Hospital, Canada
Active, not recruiting - verified November 2015

Optimizing Expectations in Cardiac Surgery Patients

Conditions:   Coronary Artery Bypass Graft Surgery (CABG);   Patients' Expectations;   Coronary Heart Disease
Interventions:   Behavioral: Expectation Manipulation Intervention;   Behavioral: Supportive Therapy
Sponsor:   Philipps University Marburg Medical Center
Completed - verified February 2016

Glucagon-like Peptide 1 Agonist Exenatide for Improved Glucose Control and Cardiac Function in Patients With Aortocoronary Bypass

Conditions:   Coronary Artery Disease;   Decreased Left Ventricular Function
Intervention:   Drug: Exenatide
Sponsors:   Charles University, Czech Republic;   Eli Lilly and Company
Completed - verified January 2016

Comparison Between High-sensitivity Cardiac Troponin T and Standard Tnl Assays in Early Cardiac Ischemia Detection

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   University of Lausanne Hospitals
Completed - verified January 2016

Study of the Natural History of FFR Guided Percutaneous Coronary Intervention

Condition:   Coronary Artery Disease
Intervention:  
Sponsors:   Seung-Jung Park;   CardioVascular Research Foundation, Korea;   St. Jude Medical (Hong Kong) Limited
Recruiting - verified January 2016

Incidence of Male Pudendal Artery Stenosis in Suboptimal Erections Study

Condition:   Erectile Dysfunction Due to Arterial Insufficiency
Intervention:  
Sponsors:   Medtronic Endovascular;   Medtronic
Terminated - verified January 2016

Treatment With Ranolazine in Microvascular Coronary Dysfunction (MCD): Impact on Angina Myocardial Ischemia

Condition:   Microvascular Coronary Dysfunction (MCD)
Interventions:   Drug: Ranolazine;   Drug: Placebo
Sponsors:   Cedars-Sinai Medical Center;   University of Florida
Recruiting - verified January 2016

Patients' Perspectives of Factors That Support the Management of Peripheral Arterial Disease for Improved Outcomes

Condition:   Peripheral Arterial Diseases
Intervention:  
Sponsor:   VA Eastern Colorado Health Care System
Active, not recruiting - verified January 2016

Evaluation of the Impact of Physical Reconditioning Associated With Specific Nutritional Supplementation in Obese Patients Suffering From Metabolic Syndrome

Conditions:   Obesity;   Metabolic Syndrome
Interventions:   Dietary Supplement: L-Leucine and L-arginine;   Other: Physical Reconditioning by a trainer
Sponsor:   University Hospital, Rouen
Completed - verified January 2016

A Study of Dalcetrapib in Patients Hospitalized For An Acute Coronary Syndrome (Dal-ACUTE)

Condition:   Coronary Heart Disease
Interventions:   Drug: dalcetrapib;   Drug: placebo
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

Investigational Device Exemption Study to Determine the Safety and Efficacy of the Astron and Pulsar Stents

Conditions:   Peripheral Artery Disease;   Peripheral Vascular Disease
Intervention:   Device: Astron/Pulsar Stents
Sponsor:   Biotronik, Inc.
Active, not recruiting - verified October 2015

A Study of RO4905417 in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery

Condition:   Coronary Heart Disease, Graft Occlusion, Vascular
Interventions:   Drug: Placebo;   Drug: RO4905417
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

International Survey of Acute Coronary Syndromes in Transitional Countries

Conditions:   Acute Coronary Syndrome;   Unstable Angina Pectoris;   Myocardial Infarction;   Coronary Disease
Intervention:  
Sponsor:   University of Bologna
Recruiting - verified January 2016

Treatment of Coronary Artery Disease (CAD) With Bare Metal Stent (BMS) Followed by Paclitaxel-Coated Balloon Catheter Versus Paclitaxel-Eluting Stent

Condition:   Coronary Artery Disease
Interventions:   Device: Coroflex Blue (BMS) followed by SeQuent Please (DEB);   Device: Coroflex Please (DES)
Sponsor:   Aesculap AG
Active, not recruiting - verified January 2016

Drug-Eluting Stents vs. Bare Metal Stents In Saphenous Vein Graft Angioplasty

Condition:   Saphenous Vein Graft Atherosclerosis
Interventions:   Device: Bare Metal Stent;   Device: Drug-Eluting Stent;   Drug: Blinded clopidogrel;   Drug: Placebo;   Drug: Thienopyridine (open-label)
Sponsor:   VA Office of Research and Development
Active, not recruiting - verified February 2016

Neurogenic Intermittent Claudication Evaluation Study

Condition:   Spinal Stenosis
Interventions:   Procedure: Aperius™ PercLID™ System;   Procedure: Standalone Decompressive Surgery
Sponsor:   Medtronic Spinal and Biologics
Completed - verified January 2016

Intermittent Neurogenic Claudication Treatment With APERIUS®

Condition:   Spinal Stenosis
Intervention:   Device: Aperius® Percutaneous Interspinous Spacer
Sponsor:   Medtronic Spinal and Biologics
Completed - verified January 2016

Study of SilverHawk®/TurboHawk® in Lower Extremity Vessels (DEFINITIVE™ LE)

Conditions:   Peripheral Arterial Disease;   Claudication;   Critical Limb Ischemia
Intervention:   Device: SilverHawk Peripheral Plaque Excision System
Sponsor:   Medtronic Endovascular
Completed - verified January 2016

Magna® Mitral Pericardial Bioprostheses Post-Approval Study Protocol

Conditions:   Coronary Artery Disease;   Mitral Valve Regurgitation;   Mitral Valve Incompetence;   Heart Failure
Intervention:   Device: CEP MAGNA MITRAL PERICARDIAL BIOPROSTHESES
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified February 2016

A Multiple Ascending Dose Study of RO4905417 in Healthy Volunteers and Patients With Peripheral Arterial Disease (PAD).

Condition:   Peripheral Arterial Disease (PAD)
Interventions:   Drug: RO4905417;   Drug: RO4905417;   Drug: RO4905417;   Drug: placebo;   Drug: placebo;   Drug: placebo
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

A Study of the Effect of RO4607381 on Atherosclerotic Plaque in Patients With Coronary Heart Disease

Condition:   Coronary Heart Disease
Interventions:   Drug: Placebo;   Drug: dalcetrapib
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome

Condition:   Coronary Heart Disease
Interventions:   Drug: Evidence-based medical care for Acute Coronary Syndrome;   Drug: Placebo;   Drug: dalcetrapib
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

A Study Assessing the Effect of RO4607381 on Vascular Function in Patients With Coronary Heart Disease (CHD) or CHD-Risk Equivalent Patients

Condition:   Coronary Heart Disease
Interventions:   Drug: Placebo;   Drug: dalcetrapib
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

A Long Term Extension of Study NC19453 Evaluating Safety and Efficacy of RO4607381

Condition:   Coronary Heart Disease
Interventions:   Drug: Placebo;   Drug: dalcetrapib
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

A Study of RO4607381 in Patients With Coronary Heart Disease (CHD) or a CHD Risk Equivalent.

Condition:   Coronary Heart Disease
Interventions:   Drug: Placebo;   Drug: dalcetrapib
Sponsor:   Hoffmann-La Roche
Completed - verified February 2016

Risk Factors for Atherogenesis in Type 1 Diabetes

Conditions:   Atherosclerosis;   Cardiovascular Diseases;   Diabetes Mellitus, Insulin-dependent;   Heart Diseases;   Diabetes Mellitus
Intervention:  
Sponsors:   University of Wisconsin, Madison;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2016

Retinal Arteriolar Abnormalities and CV Mortality

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Cerebrovascular Disorders;   Coronary Disease
Intervention:  
Sponsors:   University of Wisconsin, Madison;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2016

Novel Hemostatic Cardiac Risk Factors in Framingham

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Death, Sudden, Cardiac;   Myocardial Infarction;   Thrombosis;   Atherosclerosis;   Carotid Artery Diseases
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified March 2005