Atherosclerosis

Clinical Trial Finder

Many patients with atherosclerosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

CER-001 Atherosclerosis Regression ACS Trial

Condition:   Acute Coronary Syndromes
Intervention:   Drug: CER-001
Sponsors:   Cerenis Therapeutics, SA;   South Australian Health and Medical Research Institute
Not yet recruiting - verified June 2015

Family-based Approach to Promotion of Health Project 2

Conditions:   Lifestyle Intervention;   Atherosclerosis;   Cardiovascular Risk Factor
Interventions:   Behavioral: Intensive Individual Intervention Program;   Behavioral: Peer-To-Peer Program Intervention
Sponsors:   Icahn School of Medicine at Mount Sinai;   American Heart Association
Not yet recruiting - verified June 2015

Optimal Dose of Acetylsalicylic Acid After Coronary Artery Bypass Grafting

Condition:   Stable Coronary Artery Disease With Coronary Artery Bypass Grafting
Intervention:   Drug: Acetylsalicylic acid
Sponsors:   Karolinska University Hospital;   Karolinska Institutet
Active, not recruiting - verified June 2015

Safety and Efficacy of Autologous Concentrated Bone Marrow Aspirate for Critical Limb Ischemia - Continued Access

Conditions:   Peripheral Arterial Disease;   Peripheral Vascular Diseases;   Critical Limb Ischemia
Intervention:   Device: Bone marrow concentration device
Sponsor:   Biomet, Inc.
Temporarily not available - verified June 2015

Medtronic Polymer-Free Drug-Eluting Coronary Stent System

Condition:   Coronary Artery Disease
Intervention:   Device: Polymer-free DES (Drug Eluting Stent)
Sponsor:   Medtronic Vascular
Not yet recruiting - verified June 2015

Trial to Compare FFR Measurement With a Non-Side-Hole Guide Catheter Vs. a Side-Hole Guide Catheter

Condition:   Coronary Artery Disease
Intervention:   Other: FFR Measurement
Sponsor:   North Texas Veterans Healthcare System
Recruiting - verified June 2015

Structural Stability of Carotid Plaque and Symptomatology

Conditions:   Carotid Stenosis;   Stroke;   Carotid Artery Plaque;   Transient Ischemic Attack;   Cerebrovascular Accident;   Carotid Artery Stenosis
Intervention:   Procedure: Carotid Endarterectomy
Sponsor:   University of Wisconsin, Madison
Recruiting - verified June 2015

Oral Nutritional Supplement in Reducing Surgical Site Infections

Conditions:   Peripheral Vascular Disease;   Claudication
Intervention:   Dietary Supplement: Arginine enriched oral nutritional supplement
Sponsors:   University of Limerick;   UL Hospitals, Limerick
Not yet recruiting - verified June 2015

Study Assessing the Feasibility of Mini-MobileHeart's E-learning Module

Condition:   Coronary Artery Disease
Intervention:   Other: E-Learning
Sponsors:   Hasselt University;   Jessa Hospital
Not yet recruiting - verified June 2015

Clinical Usefulness of Fractional Flow Reserve Measurement for Significant Stenosis in Proximal Coronary Artery

Conditions:   Coronary Artery Disease;   Stenosis
Intervention:  
Sponsor:   Yonsei University
Not yet recruiting - verified June 2015

The Association Between Central Aortic Blood Pressure Indices and Severity of Coronary Artery Disease

Condition:   Coronary Artery Disease
Intervention:   Procedure: CORONARY ANGIOGRAM AND CENTRAL AORTIC WAVEFORM ANALYSIS
Sponsor:   Government Medical College, Kozhikode
Completed - verified June 2015

DANCE Partner: Inflammatory Biomarker Analysis by Femoropopliteal Revascularization Method and Treatment Outcomes

Condition:   Peripheral Arterial Disease
Interventions:   Device: Balloon Angioplasty;   Device: Atherectomy System
Sponsor:   Mercator MedSystems, Inc.
Recruiting - verified June 2015

Acute Vascular Response to Exercise in Women With Nonobstructive Coronary Artery Disease

Condition:   Nonobstructive Coronary Artery Disease
Intervention:   Other: Slow-paced walking
Sponsor:   University of Florida
Recruiting - verified June 2015

Patient Centered Home Exercise Program for Peripheral Artery Disease

Condition:   Peripheral Artery Disease
Intervention:   Behavioral: Home-based exercise intervention
Sponsors:   Northwestern University;   Patient Centered Outcome Research Institute
Recruiting - verified June 2015

Effects of Ivabradine in Patients With Stable Coronary Artery Disease Without Clinical Heart Failure

Condition:   Coronary Artery Disease.
Interventions:   Drug: Ivabradine;   Drug: Placebo
Sponsor:   Servier
Completed - verified June 2015

Safety, Hemodynamic Effects and Efficacy of Intramuscular PDA-002 in Subjects Who Have Diabetic Foot Ulcer With Peripheral Arterial Disease

Conditions:   Diabetic Foot;   Peripheral Arterial Disease
Interventions:   Drug: PDA-002;   Drug: Placebo
Sponsor:   Celgene Corporation
Recruiting - verified June 2015

Phoenix Post-Approval Registry - Using the Phoenix Atherectomy Systems

Conditions:   Peripheral Arterial Disease;   Claudication;   Critical Limb Ischemia
Intervention:   Device: Atherectomy
Sponsor:   Volcano Corporation
Not yet recruiting - verified June 2015

Ticagrelor and Peripheral Arterial Disease

Condition:   Peripheral Arterial Disease
Interventions:   Procedure: Percutaneous Peripheral Intervention;   Device: Optical Coherence Tomography;   Other: Ankle Brachial Index;   Other: Six minute walk distance assessment;   Drug: Aspirin;   Drug: Aspirin + Ticagrelor
Sponsors:   Arkansas Heart Hospital;   The University of Texas Health Science Center at San Antonio;   University of Alabama at Birmingham
Recruiting - verified June 2015

The Asahi Intecc PTCA Chronic Total Occlusion Study

Conditions:   Coronary Artery Disease;   Coronary Artery Chronic Total Occlusion
Intervention:   Device: Revascularization of Coronary Artery Chronic Total Occlusion (Corsair, Gaia, Asahi Guide Wires)
Sponsors:   Asahi Intecc USA Inc;   Medpace, Inc.
Recruiting - verified June 2015

Fractional Flow Reserve Versus Angiography Randomization for Graft Optimization Trial

Conditions:   Coronary Artery Disease;   Coronary Disease;   Myocardial Ischemia;   Arteriosclerosis;   Cardiovascular Diseases
Interventions:   Procedure: Fractional flow reserve-guided CABG;   Procedure: Angiography-guided CABG
Sponsor:   Odense University Hospital
Recruiting - verified June 2015

Coronary Flow Reserve Following Orbital Atherectomy

Condition:   Coronary Artery Disease
Intervention:   Device: Volcano FloWire
Sponsor:   Cardiovascular Systems Inc
Recruiting - verified June 2015

Effect of Permanent Internal Mammary Artery Occlusion on Extracardiac Coronary Collateral Supply

Conditions:   Circulation, Collateral;   Coronary Artery Disease;   Internal Mammary-Coronary Artery Anastomosis;   Ischemia
Intervention:   Device: Amplatzer vascular plug
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified June 2015

A Study of Evacetrapib (LY2484595) in Participants With High Cholesterol

Condition:   Hyperlipidemia
Interventions:   Drug: Evacetrapib;   Drug: Atorvastatin;   Drug: Ezetimibe;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Recruiting - verified June 2015

Walking Effect of Long Term Ticagrelor in Subjects With PAD Who Have Undergone EVR

Condition:   Peripheral Artery Disease (PAD)
Interventions:   Drug: Ticagrelor;   Drug: Comparator
Sponsors:   AstraZeneca;   CPC Clinical Research
Recruiting - verified June 2015

Ex Vivo Immunotherapy for Hyperglycemia in Type 2 Diabetes Mellitus

Conditions:   Type 2 Diabetes Mellitus;   Hyperglycemia
Intervention:   Drug: ex vivo Activated Immune Cells
Sponsors:   B & Y Technologies;   The 12th People's Hospital of Guangzhou City;   The 12th People's Hospital of Shenzhen City
Recruiting - verified June 2015

Comparison of Agent™ and SeQuent® Please Paclitaxel Coated Balloon Catheters in Coronary In-stent Restenosis (AGENT-ISR)

Conditions:   Coronary Artery Disease;   Coronary Restenosis;   Coronary Atherosclerosis;   Coronary Arteriosclerosis
Interventions:   Device: Agent Paclitaxel-coated balloon;   Device: SeQuent® Please Paclitaxel-coated Balloon
Sponsor:   Hemoteq AG
Recruiting - verified June 2015

Using Feedback Reports to Improve Medication Adherence

Conditions:   Coronary Artery Disease;   Adherence
Interventions:   Behavioral: Individual Feedback;   Behavioral: Feedback Friend
Sponsor:   Philadelphia Veterans Affairs Medical Center
Recruiting - verified May 2014

IPHAAB-study Influence of Physical Activity on Atherosclerosis Biomarkers

Condition:   Influence of 8 Months of Increased Physical Activity Workload on Osteoprotegerin and Endocan Levels
Intervention:   Other: Increased sports workload
Sponsors:   Medical University of Vienna;   Austrian Federal Ministry of Defence and Sports
Recruiting - verified June 2015

Characterization of Changes in Ventricular Mechanics in Response to Lexiscan Stress Using Tagged Cine Cardiac Magnetic Resonance Imaging

Condition:   Coronary Artery Disease
Intervention:   Drug: Regadenoson
Sponsors:   Timothy M. Bateman;   Saint Luke's Health System;   Saint Luke's Cardiovascular Consultants
Recruiting - verified June 2015

Intracoronary Infusion of Mononuclear Cells Autologous Bone Marrow in Patients With Chronic Coronary Occlusion and Ventricular Dysfunction, Previously Revascularized.

Condition:   Coronary Atherosclerosis and Other Heart Disease
Interventions:   Other: Mononuclear cells from autologous bone marrow;   Drug: Conventional medical treatment
Sponsors:   Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud;   Iniciativa Andaluza en Terapias Avanzadas 
Recruiting - verified June 2015

123I-mIBG SPECT Imaging

Conditions:   Heart Failure;   Coronary Artery Disease
Intervention:   Drug: Radioisotope
Sponsors:   Ottawa Heart Institute Research Corporation;   GE Healthcare
Recruiting - verified June 2015

Remifentanil/Sufentanil for CABG+/-AVR Evaluated by Recovery, Cognitive Function, Haemodynamics and Biochemical Markers.

Conditions:   Ischaemic Heart Disease;   Aortic Stenosis
Interventions:   Drug: Remifentanil;   Drug: Sufentanil
Sponsor:   Aarhus University Hospital
Active, not recruiting - verified June 2015

Comparison of the Ranger™ Paclitaxel-Coated PTA Balloon Catheter and Uncoated PTA Balloons in Femoropopliteal Arteries

Conditions:   Peripheral Artery Disease;   Claudication;   Atherosclerosis;   Arteriosclerosis
Interventions:   Device: Ranger DCB;   Device: uncoated PTA balloon
Sponsors:   Hemoteq AG;   Ceres GmbH evaluation & research;   CoreLab Bad Krozingen GmbH
Recruiting - verified June 2015

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified June 2015

Randomized Clinical Trial of Bococizumab (PF-04950615; RN316) in Subjects With Hyperlipidemia or Mixed Dyslipidemia at Risk of Cardiovascular Events

Condition:   Hyperlipidemia
Interventions:   Drug: Bococizumab (PF-04950615; RN316);   Other: Placebo
Sponsor:   Pfizer
Recruiting - verified June 2015

The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified June 2015

A 52 Week Study To Assess The Use Of Bococizumab (PF-04950615; RN316) In Subjects With Heterozygous Familial Hypercholesterolemia

Condition:   Heterozygous Familial Hypercholesterolemia
Interventions:   Drug: Bococizumab (PF-04950615;RN316);   Other: Placebo
Sponsor:   Pfizer
Active, not recruiting - verified June 2015

Multi-center Prospective Study to Evaluate Outcomes of the Moderate to Severely Calcified Coronary Lesions (MACE)

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   Cardiovascular Systems Inc
Recruiting - verified June 2015

Global Study of a Drug-coated Balloon to Treat Obstructive SFA and/or Popliteal Lesions

Condition:   Peripheral Arterial Disease
Intervention:   Device: CVI Paclitaxel-Coated PTA Balloon Catheter
Sponsor:   Spectranetics Corporation
Active, not recruiting - verified June 2015

A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure

Conditions:   Heart Failure;   Coronary Artery Disease
Interventions:   Drug: Rivaroxaban;   Drug: Placebo;   Other: Standard of care for heart failure and coronary artery disease
Sponsors:   Janssen Research & Development, LLC;   Bayer
Recruiting - verified June 2015

CVI Drug Coated Balloon European Randomized Clinical Trial

Conditions:   Peripheral Arterial Disease;   Claudication
Interventions:   Device: CVI Paclitaxel-coated Percutaneous Transluminal Angioplasty Balloon Catheter;   Device: Bare Percutaneous Transluminal Angioplasty Balloon Catheter
Sponsor:   Spectranetics Corporation
Active, not recruiting - verified June 2015

Observational Study to Evaluate PAD Treatment Clinical and Economic Outcomes

Condition:   Peripheral Arterial Occlusive Disease
Intervention:   Other: PAD endovascular treatments
Sponsor:   Cardiovascular Systems Inc
Recruiting - verified April 2015

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention & Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute
Recruiting - verified June 2015

Intensive Rehabilitation in Peripheral Arterial Disease With Claudication: Effects of a Treadmill Training With Active Recovery

Conditions:   Peripheral Arterial Disease;   Claudication
Interventions:   Procedure: experimental rehabilitation program;   Procedure: conventional rehabilitation program
Sponsor:   University Hospital, Grenoble
Completed - verified June 2015

EverFlex Post Approval Study

Conditions:   Peripheral Arterial Disease;   Lower Extremity Arterial Disease
Intervention:   Device: EverFlex™ Self-Expanding Peripheral Stent System
Sponsor:   Medtronic - MITG
Recruiting - verified June 2015

Prospective Characterization of the Heart, Aorta and Blood Pressure in Turner Syndrome. Association With Aortic Dissection.

Conditions:   Turner Syndrome;   Aortic Aneurysm;   Ischemic Heart Disease;   Hypertension;   Congenital Heart Defect
Intervention:  
Sponsor:   University of Aarhus
Recruiting - verified June 2015

Popliteal Artery of Treatment With Balloon Angioplasty vs. SUPERA VERITAS Peripheral Stent System

Condition:   Peripheral Vascular Disease.
Interventions:   Device: IDEV SUPERA Stent;   Device: Percutaneous Transluminal Angioplasty
Sponsor:   IDev Technologies, Inc.
Withdrawn - verified June 2015

Treatment With Ranolazine in Microvascular Coronary Dysfunction (MCD): Impact on Angina Myocardial Ischemia

Condition:   Microvascular Coronary Dysfunction (MCD)
Interventions:   Drug: Ranolazine;   Drug: Placebo
Sponsors:   Cedars-Sinai Medical Center;   University of Florida
Recruiting - verified June 2015

Influence of Varenicline on the Antiplatelet Action of Clopidogrel

Condition:   Coronary Artery Disease
Interventions:   Drug: Varenicline;   Behavioral: Counseling and psychosocial support
Sponsor:   General Hospital of Chinese Armed Police Forces
Recruiting - verified April 2015

Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression

Conditions:   Atherosclerosis;   Hypercholesterolemia
Interventions:   Drug: Statin Drugs;   Other: HMG-CoA Reductase Inhibitors
Sponsor:   National Institutes of Health Clinical Center (CC)
Active, not recruiting - verified April 2015

A Trial of Rosuvastatin in Systemic Lupus Erythematosus

Conditions:   Atherosclerosis;   Systemic Lupus Erythematosus
Interventions:   Drug: Rosuvastatin;   Drug: Placebo
Sponsor:   Imperial College London
Completed - verified June 2015

IMAGE-HF Project I-A: Cardiac Imaging in Ischemic Heart Failure (AIMI-HF)

Conditions:   Heart Failure;   Coronary Artery Disease;   Ischemic Cardiomyopathy;   Non-ischemic Cardiomyopathy
Interventions:   Other: Advanced cardiac imaging;   Other: Standard Cardiac Imaging
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research  (CIHR);   The Finnish Funding Agency for Technology and Innovation (TEKES)
Recruiting - verified June 2015

Rubidium-82 - An Alternative Radiopharmaceutical for Myocardial Imaging(Rb-ARMI)

Condition:   Coronary Artery Disease
Intervention:   Other: Myocardial perfusion imaging using Rb-82 PET or Tc-99m or Tl SPECT
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research  (CIHR)
Active, not recruiting - verified June 2015

TomVasc - Vascular Effects of Tomato Extract

Conditions:   Ischemic Heart Disease;   Transient Ischemic Attack;   Stroke;   Peripheral Vascular Disease
Interventions:   Dietary Supplement: Ateronon;   Dietary Supplement: Placebo
Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   Cambridge Theranostics Ltd
Completed - verified July 2012

Integrated Dual Exercise and Lexiscan Positron Emission Tomography: IDEALPET

Condition:   Coronary Artery Disease
Interventions:   Drug: Exercise plus Regadenoson (Lexercise);   Drug: Regadenoson (Lexiscan)
Sponsor:   Brigham and Women's Hospital
Recruiting - verified June 2015

ADDICTAO: Psychological and Addictive Profile of Patients With Buerger's Disease

Conditions:   Thromboangiitis Obliterans;   Atheromatous Arteritis
Intervention:  
Sponsor:   University Hospital, Lille
Recruiting - verified June 2015

Safety and Efficacy Study of Autologous Concentrated Bone Marrow Aspirate (cBMA) for Critical Limb Ischemia (CLI)

Conditions:   Critical Limb Ischemia;   Peripheral Arterial Disease;   Peripheral Vascular Disease
Interventions:   Device: Bone marrow concentration device;   Procedure: Placebo procedure (sham)
Sponsor:   Biomet Biologics, LLC
Active, not recruiting - verified June 2015

Treating Depression in Coronary Artery Disease With Omega-3 Fatty Acids

Conditions:   Coronary Artery Disease;   Depression
Interventions:   Dietary Supplement: Omega-3 Fatty Acid Supplement;   Other: Placebo
Sponsors:   Sunnybrook Health Sciences Centre;   Toronto Rehabilitation Institute
Active, not recruiting - verified June 2015

AngioSculpt Scoring Balloon Catheter For Bifurcation Coronary Lesions (ABC Study)

Condition:   Bifurcation Coronary Disease
Intervention:   Device: AngioSculpt
Sponsor:   HaEmek Medical Center, Israel
Terminated - verified June 2015

Renal Function in Patients Submitted to Myocardial Revascularization Surgery

Condition:   Coronary Disease
Intervention:  
Sponsors:   UPECLIN HC FM Botucatu Unesp;   Faculdade de Medicina de Botucatu, UNESP, Botucatu, Brasil;   Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Terminated - verified May 2009

Filgrastim for the Promotion of Collateral Growth in Patients With CAD

Condition:   Coronary Artery Disease
Intervention:   Drug: Filgrastim (rG-CSF)
Sponsors:   University Hospital Inselspital, Berne;   Swiss National Science Foundation;   Swiss Heart Foundation
Completed - verified June 2015

PET and Recovery Following Revascularization (PARR 2)

Conditions:   Coronary Artery Disease;   Ventricular Dysfunction, Left
Interventions:   Procedure: Positron emission tomography: FDG viability imaging;   Other: PET imaging
Sponsors:   Ottawa Heart Institute Research Corporation;   Canadian Institutes of Health Research  (CIHR);   Heart and Stroke Foundation of Ontario
Completed - verified June 2015

Inflammatory Response During Anesthesia and Surgery

Conditions:   Systemic Inflammatory Response Syndrome;   Myocardial Ischemia
Intervention:  
Sponsors:   UMC Utrecht;   European Association of Cardiothoracic Anaesthesiologists
Completed - verified June 2008

The BEAUTIFUL Study: Effects of Ivabradine in Patients With Stable Coronary Artery Disease and Left Ventricular Systolic Dysfunction

Conditions:   Coronary Disease;   Ventricular Dysfunction, Left
Interventions:   Drug: Ivabradine;   Drug: Placebo
Sponsor:   Institut de Recherches Internationales Servier
Completed - verified June 2015

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