Atherosclerosis

Clinical Trial Finder

Many patients with atherosclerosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Effect and Efficacy of Xpedition™/Alpine™, Everolimus-eluting Stent for Coronary Atherosclerosis

Conditions:   Coronary Artery Disease;   Percutaneous Coronary Intervention;   Acute Coronary Syndrome;   Angina Pectoris
Intervention:   Device: Alpine
Sponsors:   Seoul National University Hospital;   Abbott
Recruiting - verified July 2016

Clinical Study of Stent Versus Direct Atherectomy to Treat Arteriosclerosis Occlusive Disease of Lower Extremity

Conditions:   Atherosclerosis;   Ischemia
Interventions:   Device: plaque excision system;   Device: Stent
Sponsors:   Xuanwu Hospital, Beijing;   Beijing Friendship Hospital;   Beijing Chao Yang Hospital
Recruiting - verified April 2016

Orientation of the Lymphocyte Response to the Occurrence of Atherosclerotic Complications After Kidney Transplantation

Condition:   Disorder Related to Renal Transplantation
Intervention:   Other: blood sample
Sponsors:   Centre Hospitalier Universitaire de Besancon;   University of Franche-Comté;   Etablissement Français du Sang
Recruiting - verified July 2016

Investigation on the Effect of Carnitine Supplement on Gut Microbiota and TMAO Plasma Concentration

Condition:   Atherosclerosis
Intervention:   Dietary Supplement: L-carnitine
Sponsor:   National Taiwan University Hospital
Recruiting - verified July 2016

Sildenafil Efficacy Study on Time Walk From Peripheral Arterial Desease Patients (Stade II) With Arterial Claudication

Condition:   Peripheral Arterial Occlusive Disease
Interventions:   Drug: Sildenafil 100mg single oral dose;   Drug: Placebo, Oral intake single dose
Sponsor:   University Hospital, Angers
Not yet recruiting - verified July 2016

Umbilical Cord Mesenchymal Stem Cells Infusion for Diabetes Related Vascular Complications

Conditions:   Peripheral Vascular Disease;   Ischemia;   Diabetic Foot
Interventions:   Biological: Umbilical Cord Mesenchymal Stem Cells;   Biological: saline
Sponsors:   Jie Shen;   Nanfang Hospital of Southern Medical University;   Academy Military Medical Science, China;   The Fifth Affiliated Hospital of Southern Medical University;   Southern Medical University, China
Recruiting - verified July 2016

GEOHealth Hub: Household Air Pollution and Cardio-pulmonary and Immune Function Outcomes

Conditions:   Household Air Polution;   Cardiovascular Diseases;   Lung Diseases;   Immune Dysfunction
Intervention:   Device: Improved cook stove
Sponsors:   International Centre for Diarrhoeal Disease Research, Bangladesh;   John E. Fogarty International Center (FIC);   National Institute of Environmental Health Sciences (NIEHS);   University of Chicago;   York University;   UChicago Research, Bangladesh;   Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh;   Bangladesh Atomic Energy commission
Not yet recruiting - verified June 2016

Ultrasound-guided Femoral Vein Accessibility, Safety and Time for Atrial Fibrillation Treatment

Conditions:   Atrial Fibrillation;   Peripheral Vascular Disease;   Vascular Access Complications
Interventions:   Device: Real-time ultrasound-guided puncture;   Other: Anatomical landmark guided puncture
Sponsor:   Kenichiro Yamagata
Recruiting - verified July 2016

Evaluation and Management of Cardiovascular Risk Factors in Inflammatory and Acquired Dysimmune Diseases (CARMIN)

Condition:   Inflammatory and Acquired Dysimmune Diseases
Intervention:   Other: Data collection
Sponsor:   Hospices Civils de Lyon
Completed - verified July 2016

Ramipril Treatment of Claudication

Condition:   Peripheral Arterial Disease
Intervention:   Drug: Ramipril
Sponsor:   University of Nebraska
Recruiting - verified July 2016

Tissue Lesions in Exercise Related Ischemia

Conditions:   Ischemia;   Peripheral Artery Disease
Intervention:   Other: Muscle Biopsy
Sponsor:   University Hospital, Angers
Not yet recruiting - verified July 2016

Tack Optimized Drug Coated Balloon Angioplasty Study of the Tack Endovascular System™ in Femoropoliteal Arteries

Condition:   Peripheral Arterial Disease
Intervention:   Device: Tack Endovascular System
Sponsor:   Intact Vascular
Recruiting - verified July 2016

Study of Supplement's Antioxidant Properties That Contains Natural Extracts

Condition:   Healthy
Interventions:   Dietary Supplement: Mind Master;   Dietary Supplement: Placebo
Sponsor:   Harokopio University
Active, not recruiting - verified July 2016

FGF21 Can Help Predicting Arterial Stiffness Measured by Cardio-ankle Vascular Index in Renal Transplant Patients

Condition:   Vascular Stiffness
Intervention:   Other: CAVI and FGF-21
Sponsor:   Bangkok Metropolitan Administration Medical College and Vajira Hospital
Completed - verified July 2016

A Single Arm Trial Evaluating the BARD Lutonix Drug-Coated Balloon (LTX DCB) for Treatment of Femoropopliteal Arteries

Conditions:   Femoral Artery Stenosis;   Femoral Artery Occlusion;   Stenosis of Popliteal Arteries;   Occlusion of Popliteal Arteries
Intervention:   Device: LTX DCB
Sponsor:   C. R. Bard
Recruiting - verified July 2016

Safety and Efficacy of Allogeneic MSCs in Promoting T-regulatory Cells in Patients With Small Abdominal Aortic Aneurysms

Conditions:   AAA;   Abdominal Aortic Aneurysm;   Vascular Disease;   Peripheral Artery Disease
Interventions:   Biological: Intravenous infusion of Plasmalyte A (placebo);   Biological: Intravenous infusion of 1 million allogeneic MSCs/kg;   Biological: Intravenous infusion of 3 million allogeneic MSCs/kg
Sponsor:   Michael Murphy
Not yet recruiting - verified July 2016

A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation

Conditions:   Ischemia;   Peripheral Arterial Disease;   Peripheral Vascular Disease;   Vascular Disease;   Arterial Occlusive Disease;   Arteriosclerosis;   Atherosclerosis;   Cardiovascular Disease;   Pathologic Processes;   Orthopedic Procedures;   Amputation
Intervention:   Biological: Allogeneic bone marrow derived mesenchymal stem cells
Sponsor:   Indiana University
Recruiting - verified July 2016

Excellence In Peripheral Artery Disease Thrombin Receptor Antagonist Intervention In Claudication Evaluation (XLPAD-TRACE Trial)

Condition:   Peripheral Arterial Disease
Interventions:   Drug: Placebo + background APT + SMT;   Drug: Vorapaxar 2.08 mg/d + background APT + SMT.
Sponsor:   North Texas Veterans Healthcare System
Recruiting - verified July 2016

BOLD MRI as a Surrogate of Improved Muscle Oxygenation Following Endovascular Therapy for the Treatment of CLI

Conditions:   Peripheral Arterial Disease;   Critical Limb Ischemia
Intervention:   Other: BOLD-MRI
Sponsor:   Biomet, Inc.
Recruiting - verified May 2016

Study of the Effect of Atorvastatin for Reducing Aging-related Complication in HIV-infected Patients Older Than 45 Years Receiving a Protease Inhibitor-based Regimen Versus a Raltegravir-based Regimen

Condition:   Aging-related Inflammation in HIV-infected Patients
Interventions:   Drug: Raltegravir;   Drug: PI-based regimen;   Drug: Atorvastatin
Sponsor:   Fundacio Lluita Contra la SIDA
Recruiting - verified July 2016

A phase3 Study Measuring the Effect of Rosuvastatin 20 mg on Carotid Intima-Media Thickness in Chinese Subjects With Subclinical Atherosclerosis

Condition:   Atherosclerosis
Interventions:   Drug: Rosuvastatin;   Drug: Placebo
Sponsor:   AstraZeneca
Recruiting - verified July 2016

Tack Optimized Balloon Angioplasty Study of the Tack Endovascular System™ in Femoropoliteal Arteries

Condition:   Peripheral Artery Disease
Intervention:   Device: Tack Endovascular System
Sponsor:   Intact Vascular
Recruiting - verified June 2016

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Recruiting - verified July 2016

"All Comers" Post Market Clinical Follow-up (PMCF) With Multi-LOC for flOw liMiting Outcomes

Condition:   Peripheral Arterial Occlusive Disease
Intervention:   Device: VascuFlex Multi-LOC®
Sponsors:   B. Braun Melsungen AG;   Diakonissenkrankenhaus Mannheim
Recruiting - verified July 2016

DANCE Partner: Inflammatory Biomarker Analysis by Femoropopliteal Revascularization Method and Treatment Outcomes

Condition:   Peripheral Arterial Disease
Interventions:   Device: Balloon Angioplasty;   Device: Atherectomy System
Sponsor:   Mercator MedSystems, Inc.
Recruiting - verified July 2016

Safety and Effectiveness of the Orsiro Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions

Conditions:   Coronary Artery Disease;   Atherosclerosis, Coronary;   Myocardial Ischemia;   Ischemic Heart Disease;   Acute Coronary Syndrome;   Angina Pectoris
Interventions:   Device: Orsiro DES;   Device: Xience DES
Sponsors:   Biotronik, Inc.;   Biotronik AG;   Harvard Clinical Research Institute;   Medstar Research Institute
Active, not recruiting - verified July 2016

Clinical Post Market Clinical Follow-up (PMCF) on Peripheral Arteries Treated With SeQuent® Please Over The Wire (OTW)

Condition:   Peripheral Arterial Occlusive Disease
Interventions:   Procedure: drug coated balloon angioplasty;   Device: SeQuent® Please OTW Paclitaxel Coated Balloon Catheter
Sponsor:   B. Braun Melsungen AG
Recruiting - verified July 2016

Atherosclerotic Plaque Characteristics Associated With a Progression Rate of the Plaque in Carotids and a Risk of Stroke

Condition:   Carotid Artery Plaque
Intervention:  
Sponsors:   University Hospital Ostrava;   General Teaching Hospital, Prague;   Charles University, Czech Republic;   Palacky University
Recruiting - verified July 2016

Combined Coronary and Cerebral Angiography and Intervention for Coronary and Cerebrovascular Atherosclerosis

Conditions:   Coronary Stenosis;   Cerebral Stenosis
Interventions:   Other: simultaneous coronary and cerebral intervention;   Other: staged coronary and cerebral intervention
Sponsor:   Capital Medical University
Recruiting - verified July 2016

Efficacy and Safety of Intramuscular PDA-002 in Subjects Who Have Diabetic Foot Ulcer With and Without Peripheral Arterial Disease

Conditions:   Peripheral Arterial Disease;   Diabetic Foot
Interventions:   Biological: 3 x 10^6 cells;   Biological: 10 x 10^6 cells;   Biological: 30 x 10^6 cells;   Other: Placebo
Sponsor:   Celgene Corporation
Recruiting - verified July 2016

Zilver Flex Post-Market Study in Japan

Condition:   Peripheral Arterial Disease (PAD)
Intervention:   Device: Zilver Flex Bare Metal Stent
Sponsor:   Cook
Active, not recruiting - verified July 2016

Vascular Effects of Achieving Minimal Disease Activity in Psoriatic Arthritis - a 2 Year Prospective Cohort Study

Conditions:   Psoriatic Arthritis;   Atherosclerosis;   Arterial Stiffness
Intervention:   Other: PsA MDA
Sponsor:   Chinese University of Hong Kong
Active, not recruiting - verified July 2016

Registry of Cutting Balloon and DCB Intervention in Femoropopliteal Stenosis/Occlusion.

Conditions:   Peripheral Artery Disease;   Femoropoliteal Stenosis/Occlusion;   Cutting-balloon;   Drug-coated-balloon
Intervention:   Device: Cutting-Balloon-PTA (VascuTrak) and Drug Coated Ballon PTA
Sponsor:   Caritasklinik St. Theresia
Active, not recruiting - verified July 2016

3D Multi-Contrast Atherosclerosis Characterization of the Carotid Artery

Condition:   Carotid Artery Disease
Intervention:   Other: MRI with/without contrast
Sponsors:   Cedars-Sinai Medical Center;   National Heart, Lung, and Blood Institute (NHLBI);   American Heart Association
Recruiting - verified July 2016

GISSI Outliers CAPIRE

Condition:   Atherosclerosis
Intervention:  
Sponsor:   Gruppo di Ricerca GISSI
Active, not recruiting - verified July 2016

TurboHawk™ Japan Trial in Patients With PAD

Condition:   Peripheral Arterial Disease
Intervention:   Device: Atherectomy Catheter
Sponsor:   Medtronic Endovascular
Completed - verified July 2016

The IN.PACT SFA Clinical Study for the Treatment of Atherosclerotic Lesions in the Superficial Femoral Artery and/or Proximal Popliteal Artery Using the IN.PACT Admiral™ Drug-Eluting Balloon in a Chinese Patient Population

Condition:   Atherosclerosis
Intervention:   Device: IN.PACT Admiral Paclitaxel-Eluting Percutaneous Transluminal Angioplasty (PTA) Balloon Catheter
Sponsor:   Medtronic Endovascular
Active, not recruiting - verified July 2016

Registry of the Magellan Robotic System

Condition:   Peripheral Vascular Disease
Intervention:  
Sponsor:   Hansen Medical
Recruiting - verified July 2016

The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Active, not recruiting - verified July 2016

Study of Human Placenta-derived Cells (PDA002) to Evaluate the Safety and Effectiveness in Subjects With PAD and DFU

Conditions:   Peripheral Arterial Disease;   Diabetic Foot
Interventions:   Biological: 3 x 10^6 cells;   Biological: 10 x 10^6 cells;   Biological: 30 x 10^6 cells;   Biological: 100 x 10^6 cells
Sponsor:   Celgene Corporation
Active, not recruiting - verified July 2016

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention &Amp; Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute
Recruiting - verified July 2016

Prevalence of Different Haptoglobin Phenotypes in Patients With COPD- Frequent Exacerbators Versus Non Exacerbators

Condition:   Pulmonary Disease, Chronic Obstructive
Intervention:  
Sponsors:   Carmel Medical Center;   Technion, Israel Institute of Technology
Completed - verified July 2016

EverFlex Post Approval Study

Conditions:   Peripheral Arterial Disease;   Lower Extremity Arterial Disease
Intervention:   Device: EverFlex™ Self-Expanding Peripheral Stent System
Sponsor:   Medtronic Endovascular
Recruiting - verified July 2016

Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02)

Conditions:   Carotid Stenosis;   Atherosclerosis;   Stroke;   Transient-ischaemic Attack;   TIA;   Amaurosis Fugax
Interventions:   Drug: Revacept;   Drug: Placebo
Sponsor:   AdvanceCor GmbH
Recruiting - verified July 2016

Aggressive Cholesterol Therapy to Inhibit Vein Graft Events After CABG (ACTIVE Trial)

Condition:   Saphenous Vein Graft Disease
Interventions:   Drug: Atorvastatin 80 mg daily;   Drug: Atorvastatin 10 mg daily
Sponsors:   Boca Raton Regional Hospital;   Pfizer
Active, not recruiting - verified July 2016

Pilot Study to Determine Percent Tissue Perfusion and Cellular Viability Using SPY Imaging

Condition:   Peripheral Vascular Disease
Interventions:   Device: SPY Imaging, ICG dye (0.2 - 0.5 mg/kg);   Device: SPY Imaging
Sponsor:   Georgetown University
Recruiting - verified July 2016

Safety Study of Bone Marrow Cell Concentrate Prepared Using the Magellan System to Treat Critical Limb Ischemia (CLI)

Conditions:   Critical Limb Ischemia (CLI);   Peripheral Vascular Disease (PVD)
Intervention:   Device: Magellan®
Sponsor:   Arteriocyte, Inc.
Active, not recruiting - verified July 2016

Clinical Trial for Dose Finding and Safety of RVX000222 in Subjects With Stable Coronary Artery Disease

Conditions:   Atherosclerosis;   Coronary Artery Disease
Interventions:   Drug: RVX000222;   Drug: Placebo
Sponsor:   Resverlogix Corp
Completed - verified July 2016

Safety, Pharmacokinetic Study of RVX000222 in Healthy Subjects and Subjects With Low HDL Cholesterol

Conditions:   Dyslipidemia;   Atherosclerosis;   Acute Coronary Syndrome;   Cardiovascular Disease
Interventions:   Drug: RVX000222;   Drug: Placebo
Sponsor:   Resverlogix Corp
Completed - verified July 2016

Using Differences in Peripheral Blood Leukocyte Gene Expression to Determine Cardiovascular Disease Risk

Conditions:   Atherosclerosis;   Cardiovascular Diseases
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified April 2009

Association Between Abdominal Body Composition, Inflammation, and Risk for Cardiovascular Disease (The MESA ABD Study)

Conditions:   Cardiovascular Diseases;   Obesity
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified February 2009

RESPECT PFO Clinical Trial

Condition:   Cryptogenic Stroke
Interventions:   Device: AMPLATZER PFO Occluder;   Other: Standard of Care - Medical Management
Sponsor:   St. Jude Medical
Active, not recruiting - verified July 2016

Identifying Genes That May Increase the Risk for Heart Disease in African Americans

Condition:   Heart Diseases
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified October 2006

Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen

Condition:   Arthritis, Rheumatoid
Interventions:   Drug: celecoxib;   Drug: Ibuprofen;   Drug: Naproxen
Sponsors:   Pfizer;   The Cleveland Clinic
Completed - verified July 2016

Estrogen Receptor Variants, HDL, and Atherosclerosis

Conditions:   Cardiovascular Diseases;   Atherosclerosis;   Coronary Arteriosclerosis;   Heart Diseases
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

The ARIC MRI Study

Conditions:   Cardiovascular Diseases;   Cerebrovascular Disorders;   Cerebrovascular Accident
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified October 2008

Cardiac MR of Subclinical CVD: Impact of Age

Conditions:   Atherosclerosis;   Heart Diseases;   Cardiovascular Diseases;   Hypertrophy, Left Ventricular
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

Epidemiology of Cardiovascular Disease in Diabetes

Conditions:   Cardiovascular Diseases;   Diabetes Mellitus, Non-insulin Dependent;   Heart Diseases;   Atherosclerosis;   Diabetes Mellitus
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

MRI Derived Organ & Tissue Mass Changes With Weight Loss - Ancillary to Look AHEAD

Conditions:   Cardiovascular Diseases;   Atherosclerosis;   Obesity;   Diabetes Mellitus, Non-insulin Dependent;   Heart Diseases;   Myocardial Infarction;   Diabetes Mellitus
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

Non-Traditional Cardiovascular Risk Factors in Type 2 Diabetes Mellitus - Ancillary to VA Study of Glycemic Control

Conditions:   Atherosclerosis;   Cardiovascular Diseases;   Diabetes Mellitus;   Diabetes Mellitus, Non-insulin Dependent;   Heart Diseases
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

Genetic Architecture of Plasma T-PA and PAI-1

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Thrombosis;   Atherosclerosis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

Genetics of Coronary Artery Disease in Alaskan Natives (GOCADAN)

Conditions:   Heart Diseases;   Cardiovascular Diseases;   Atherosclerosis;   Hypertension;   Diabetes Mellitus;   Coronary Arteriosclerosis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified May 2009

Multi-Ethnic Study of Atherosclerosis (MESA)

Conditions:   Atherosclerosis;   Cardiovascular Diseases;   Heart Diseases;   Coronary Artery Disease;   Coronary Disease;   Stroke;   Myocardial Infarction;   Heart Failure;   Diabetes Mellitus, Type 2;   Hypertension;   Diabetes Mellitus
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified April 2012

Risk of Coronary Heart Disease in Women With Polycystic Ovary Syndrome

Conditions:   Atherosclerosis;   Cardiovascular Diseases;   Heart Diseases;   Carotid Artery Diseases;   Coronary Disease;   Polycystic Ovary Syndrome
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

Strong Heart Study

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Atherosclerosis;   Asthma;   Carotid Artery Diseases;   Coronary Disease;   Hypercholesterolemia;   Hypertension;   Diabetes Mellitus;   Obesity
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified May 2009