Atherosclerosis

Clinical Trial Finder

Many patients with atherosclerosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Clinical Study of Stent Versus Direct Atherectomy to Treat Arteriosclerosis Occlusive Disease of Lower Extremity

Conditions:   Atherosclerosis;   Ischemia
Interventions:   Device: plaque excision system;   Device: Stent
Sponsors:   Xuanwu Hospital, Beijing;   Beijing Friendship Hospital;   Beijing Chao Yang Hospital
Recruiting - verified April 2016

The TRUST Study - CardioVascular Imaging IMT

Conditions:   Thyroid Dysfunction;   Atherosclerosis;   Heart Failure
Interventions:   Drug: Levothyroxine;   Drug: Placebo
Sponsors:   University Hospital Inselspital, Berne;   University of Lausanne Hospitals;   University Hospital, Geneva
Recruiting - verified July 2016

The TRUST Trial - CardioVascular Imaging ECHO

Conditions:   Thyroid Dysfunction;   Atherosclerosis;   Heart Failure
Interventions:   Drug: Levothyroxine;   Drug: Placebo
Sponsors:   University Hospital Inselspital, Berne;   University of Lausanne Hospitals;   University Hospital, Geneva
Recruiting - verified July 2016

Investigation on the Effect of Carnitine Supplement on Gut Microbiota and TMAO Plasma Concentration

Condition:   Atherosclerosis
Intervention:   Dietary Supplement: L-carnitine
Sponsor:   National Taiwan University Hospital
Recruiting - verified July 2016

Sildenafil Efficacy Study on Time Walk From Peripheral Arterial Desease Patients (Stade II) With Arterial Claudication

Condition:   Peripheral Arterial Occlusive Disease
Interventions:   Drug: Sildenafil 100mg single oral dose;   Drug: Placebo, Oral intake single dose
Sponsor:   University Hospital, Angers
Not yet recruiting - verified July 2016

A Clinical Study Using Adipose-derived Stem Cells for Diabetic Foot

Conditions:   Peripheral Vascular Disease;   Ischemia;   Diabetic Foot
Interventions:   Biological: Adipose-derived stem cell;   Biological: saline
Sponsors:   Jie Shen;   Nanfang Hospital of Southern Medical University;   Academy Military Medical Science, China;   The Fifth Affiliated Hospital of Southern Medical University;   Southern Medical University, China
Recruiting - verified July 2016

Umbilical Cord Mesenchymal Stem Cells Infusion for Diabetes Related Vascular Complications

Conditions:   Peripheral Vascular Disease;   Ischemia;   Diabetic Foot
Interventions:   Biological: Umbilical Cord Mesenchymal Stem Cells;   Biological: saline
Sponsors:   Jie Shen;   Nanfang Hospital of Southern Medical University;   Academy Military Medical Science, China;   The Fifth Affiliated Hospital of Southern Medical University;   Southern Medical University, China
Recruiting - verified July 2016

Ultrasound-guided Femoral Vein Accessibility, Safety and Time for Atrial Fibrillation Treatment

Conditions:   Atrial Fibrillation;   Peripheral Vascular Disease;   Vascular Access Complications
Interventions:   Device: Real-time ultrasound-guided puncture;   Other: Anatomical landmark guided puncture
Sponsor:   Kenichiro Yamagata
Recruiting - verified July 2016

Evaluation and Management of Cardiovascular Risk Factors in Inflammatory and Acquired Dysimmune Diseases (CARMIN)

Condition:   Inflammatory and Acquired Dysimmune Diseases
Intervention:   Other: Data collection
Sponsor:   Hospices Civils de Lyon
Completed - verified July 2016

Ramipril Treatment of Claudication

Condition:   Peripheral Arterial Disease
Intervention:   Drug: Ramipril
Sponsor:   University of Nebraska
Recruiting - verified July 2016

Tissue Lesions in Exercise Related Ischemia

Conditions:   Ischemia;   Peripheral Artery Disease
Intervention:   Other: Muscle Biopsy
Sponsor:   University Hospital, Angers
Not yet recruiting - verified July 2016

Claudication Evaluation During Rowing ExerciseS

Condition:   Peripheral Artery Disease
Intervention:  
Sponsor:   University Hospital, Angers
Not yet recruiting - verified July 2016

A Clinical Study Using Autologous Bone Marrow Stem Cell for Diabetes Related Vascular Complications

Conditions:   Peripheral Vascular Disease;   Ischemia;   Diabetic Foot
Interventions:   Biological: mesenchymal stem cells;   Biological: saline
Sponsors:   Jie Shen;   Nanfang Hospital of Southern Medical University;   Academy Military Medical Science, China;   The Fifth Affiliated Hospital of Southern Medical University;   Southern Medical University, China
Recruiting - verified July 2016

Study of Supplement's Antioxidant Properties That Contains Natural Extracts

Condition:   Healthy
Interventions:   Dietary Supplement: Mind Master;   Dietary Supplement: Placebo
Sponsor:   Harokopio University
Active, not recruiting - verified July 2016

Tele-Health Electronic Monitoring to Reduce Post Discharge Complications and Surgical Site Infections

Condition:   Peripheral Vascular Disease
Intervention:   Other: Tele-Health Electronic Monitoring (THEM)
Sponsors:   CAMC Health System;   WVCTSI
Enrolling by invitation - verified July 2016

FGF21 Can Help Predicting Arterial Stiffness Measured by Cardio-ankle Vascular Index in Renal Transplant Patients

Condition:   Vascular Stiffness
Intervention:   Other: CAVI and FGF-21
Sponsor:   Bangkok Metropolitan Administration Medical College and Vajira Hospital
Completed - verified July 2016

A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation

Conditions:   Ischemia;   Peripheral Arterial Disease;   Peripheral Vascular Disease;   Vascular Disease;   Arterial Occlusive Disease;   Arteriosclerosis;   Atherosclerosis;   Cardiovascular Disease;   Pathologic Processes;   Orthopedic Procedures;   Amputation
Intervention:   Biological: Allogeneic bone marrow derived mesenchymal stem cells
Sponsor:   Indiana University
Recruiting - verified July 2016

Exercise Training in Individuals With Peripheral Arterial Disease

Conditions:   Peripheral Arterial Disease;   Intermittent Claudication
Intervention:   Other: Exercise training
Sponsor:   University Medical Centre Ljubljana
Recruiting - verified June 2016

The Cholesterol Lowering Effects of Strawberry

Conditions:   Hypercholesterolemia;   Glycemic Response
Interventions:   Dietary Supplement: Active Treatment Beverage;   Dietary Supplement: Placebo Treatment Beverage
Sponsor:   Institute for Food Safety and Health, United States
Recruiting - verified July 2016

BOLD MRI as a Surrogate of Improved Muscle Oxygenation Following Endovascular Therapy for the Treatment of CLI

Conditions:   Peripheral Arterial Disease;   Critical Limb Ischemia
Intervention:   Other: BOLD-MRI
Sponsor:   Biomet, Inc.
Recruiting - verified May 2016

Clinical Study of Stent Versus Direct Atherectomy Versus Angioplasty to Treat Lower Limb In-stent Restenosis

Conditions:   Atherosclerosis;   In-stent Arterial Restenosis
Interventions:   Device: plaque excision system;   Device: stent;   Device: Balloon
Sponsor:   Xuanwu Hospital, Beijing
Recruiting - verified March 2016

iPhone App Compared to Standard RR-measurement

Conditions:   Hypertension;   Blood Pressure
Interventions:   Device: cuff device (Omron HBP-1300-E Pro);   Device: iPhone 4s
Sponsors:   Jens Eckstein;   Preventicus GmbH
Active, not recruiting - verified July 2016

Clinical Study of Stent Versus Direct Atherectomy to Treat Lower Limb Ischemia

Conditions:   Atherosclerosis;   Ischemia
Interventions:   Device: plaque excision system;   Device: Stent
Sponsor:   Xuanwu Hospital, Beijing
Completed - verified December 2015

"All Comers" Post Market Clinical Follow-up (PMCF) With Multi-LOC for flOw liMiting Outcomes

Condition:   Peripheral Arterial Occlusive Disease
Intervention:   Device: VascuFlex Multi-LOC®
Sponsors:   B. Braun Melsungen AG;   Diakonissenkrankenhaus Mannheim
Recruiting - verified July 2016

DANCE Partner: Inflammatory Biomarker Analysis by Femoropopliteal Revascularization Method and Treatment Outcomes

Condition:   Peripheral Arterial Disease
Interventions:   Device: Balloon Angioplasty;   Device: Atherectomy System
Sponsor:   Mercator MedSystems, Inc.
Recruiting - verified July 2016

Vascular Ultrasound Screening in Patients With Ischemic Cerebrovascular Disease: a Multi-center Registry Study

Condition:   Stroke
Intervention:  
Sponsors:   Xuanwu Hospital, Beijing;   The First Affiliated Hospital of Shanxi Medical University;   Liaocheng Brains Hospital;   Tianjin Huanhu Hospital;   Baotou City Central Hospital;   First Hospital of Jilin University;   First Affiliated Hospital of Harbin Medical University;   First Hospital of China Medical University;   LanZhou University;   First Affiliated Hospital of Xinjiang Medical University;   The First Affiliated Hospital of Soochow University;   Anhui Provincial Hospital;   Guangdong Provincial Hospital of Traditional Chinese Medicine;   ZhuHai Hospital;   Fujian Provincial Hospital;   Mianyang Central Hospital;   The Second Affiliated Hospital of Kunming Medical University;   Brains Hospital of Hunan Province;   Henan Provincial Hospital;   Luoyang Central Hospital;   National Health and Family Planning Commission Stroke Prevention Engineering Committee;   Dalian Municipal Central Hospital
Completed - verified July 2016

Ticagrelor and Peripheral Arterial Disease

Condition:   Peripheral Arterial Disease
Interventions:   Procedure: Percutaneous Peripheral Intervention;   Device: Optical Coherence Tomography;   Other: Ankle Brachial Index;   Other: Six minute walk distance assessment;   Drug: Aspirin;   Drug: Aspirin + Ticagrelor
Sponsors:   Arkansas Heart Hospital;   The University of Texas Health Science Center at San Antonio;   University of Alabama at Birmingham
Recruiting - verified July 2016

Safety and Effectiveness of the Orsiro Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions

Conditions:   Coronary Artery Disease;   Atherosclerosis, Coronary;   Myocardial Ischemia;   Ischemic Heart Disease;   Acute Coronary Syndrome;   Angina Pectoris
Interventions:   Device: Orsiro DES;   Device: Xience DES
Sponsors:   Biotronik, Inc.;   Biotronik AG;   Harvard Clinical Research Institute;   Medstar Research Institute
Active, not recruiting - verified July 2016

Clinical Post Market Clinical Follow-up (PMCF) on Peripheral Arteries Treated With SeQuent® Please Over The Wire (OTW)

Condition:   Peripheral Arterial Occlusive Disease
Interventions:   Procedure: drug coated balloon angioplasty;   Device: SeQuent® Please OTW Paclitaxel Coated Balloon Catheter
Sponsor:   B. Braun Melsungen AG
Recruiting - verified July 2016

Combined Coronary and Cerebral Angiography and Intervention for Coronary and Cerebrovascular Atherosclerosis

Conditions:   Coronary Stenosis;   Cerebral Stenosis
Interventions:   Other: simultaneous coronary and cerebral intervention;   Other: staged coronary and cerebral intervention
Sponsor:   Capital Medical University
Recruiting - verified July 2016

Efficacy and Safety of Intramuscular PDA-002 in Subjects Who Have Diabetic Foot Ulcer With and Without Peripheral Arterial Disease

Conditions:   Peripheral Arterial Disease;   Diabetic Foot
Interventions:   Biological: 3 x 10^6 cells;   Biological: 10 x 10^6 cells;   Biological: 30 x 10^6 cells;   Other: Placebo
Sponsor:   Celgene Corporation
Recruiting - verified July 2016

Registry of Cutting Balloon and DCB Intervention in Femoropopliteal Stenosis/Occlusion.

Conditions:   Peripheral Artery Disease;   Femoropoliteal Stenosis/Occlusion;   Cutting-balloon;   Drug-coated-balloon
Intervention:   Device: Cutting-Balloon-PTA (VascuTrak) and Drug Coated Ballon PTA
Sponsor:   Caritasklinik St. Theresia
Active, not recruiting - verified July 2016

3D Multi-Contrast Atherosclerosis Characterization of the Carotid Artery

Condition:   Carotid Artery Disease
Intervention:   Other: MRI with/without contrast
Sponsors:   Cedars-Sinai Medical Center;   National Heart, Lung, and Blood Institute (NHLBI);   American Heart Association
Recruiting - verified July 2016

Use and Safety of the LUTONIX® Drug Coated Balloon Catheter in Arteries of the Lower Extremity

Condition:   Peripheral Artery Disease
Intervention:   Device: Lutonix Drug Coated Balloon Catheter
Sponsor:   C. R. Bard
Terminated - verified July 2016

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified July 2016

Study of Human Placenta-derived Cells (PDA002) to Evaluate the Safety and Effectiveness in Subjects With PAD and DFU

Conditions:   Peripheral Arterial Disease;   Diabetic Foot
Interventions:   Biological: 3 x 10^6 cells;   Biological: 10 x 10^6 cells;   Biological: 30 x 10^6 cells;   Biological: 100 x 10^6 cells
Sponsor:   Celgene Corporation
Active, not recruiting - verified July 2016

The Psoriasis, Atherosclerosis, and Cardiometabolic Disease Initiative (PACI)

Conditions:   Metabolic Disease;   Cardiovascular Disease;   Inflammation
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified July 2016

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention &Amp; Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute
Recruiting - verified July 2016

EverFlex Post Approval Study

Conditions:   Peripheral Arterial Disease;   Lower Extremity Arterial Disease
Intervention:   Device: EverFlex™ Self-Expanding Peripheral Stent System
Sponsor:   Medtronic Endovascular
Recruiting - verified July 2016

Revacept in Symptomatic Carotid Stenosis (Revacept/CS/02)

Conditions:   Carotid Stenosis;   Atherosclerosis;   Stroke;   Transient-ischaemic Attack;   TIA;   Amaurosis Fugax
Interventions:   Drug: Revacept;   Drug: Placebo
Sponsor:   AdvanceCor GmbH
Recruiting - verified July 2016

Aggressive Cholesterol Therapy to Inhibit Vein Graft Events After CABG (ACTIVE Trial)

Condition:   Saphenous Vein Graft Disease
Interventions:   Drug: Atorvastatin 80 mg daily;   Drug: Atorvastatin 10 mg daily
Sponsors:   Boca Raton Regional Hospital;   Pfizer
Active, not recruiting - verified July 2016

Clinical Trial for Dose Finding and Safety of RVX000222 in Subjects With Stable Coronary Artery Disease

Conditions:   Atherosclerosis;   Coronary Artery Disease
Interventions:   Drug: RVX000222;   Drug: Placebo
Sponsor:   Resverlogix Corp
Completed - verified July 2016

Safety, Pharmacokinetic Study of RVX000222 in Healthy Subjects and Subjects With Low HDL Cholesterol

Conditions:   Dyslipidemia;   Atherosclerosis;   Acute Coronary Syndrome;   Cardiovascular Disease
Intervention:   Drug: RVX000222 (common name RVX-208)
Sponsor:   Resverlogix Corp
Completed - verified July 2016

RESPECT PFO Clinical Trial

Condition:   Cryptogenic Stroke
Interventions:   Device: AMPLATZER PFO Occluder;   Other: Standard of Care - Medical Management
Sponsor:   St. Jude Medical
Active, not recruiting - verified July 2016

Genetic Factors in Atherosclerosis

Condition:   Atherosclerosis
Intervention:  
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Completed - verified March 2013

Gene-Specific Responses to Exercise in Discordant Twins

Conditions:   Atherosclerosis;   Cardiovascular Diseases;   Heart Diseases
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2008

Identification of Genes Predisposing to Atherosclerosis

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Heart Diseases
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2008

Cardiac MR of Subclinical CVD: Impact of Age

Conditions:   Atherosclerosis;   Heart Diseases;   Cardiovascular Diseases;   Hypertrophy, Left Ventricular
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2008

Genetics of Atherosclerosis in Mexican Americans

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Obesity;   Atherosclerosis;   Diabetes Mellitus, Non-insulin Dependent;   Diabetes Mellitus
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified July 2008

Women's Estrogen/Progestin Lipid Lowering Hormone Atherosclerosis Regression Trial (WELL-HART)

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Heart Diseases;   Myocardial Ischemia;   Postmenopause
Interventions:   Drug: estrogen replacement therapy;   Drug: hormone replacement therapy;   Drug: estradiol;   Drug: medroxyprogesterone
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified May 2005

Women's Angiographic Vitamin and Estrogen Trial (WAVE)

Conditions:   Cardiovascular Diseases;   Coronary Arteriosclerosis;   Coronary Disease;   Heart Diseases;   Myocardial Ischemia;   Postmenopause
Interventions:   Drug: estrogen replacement therapy;   Drug: estrogens, conjugated;   Drug: progesterone;   Drug: hormone replacement therapy;   Drug: supplementation, food;   Drug: ascorbic acid;   Drug: vitamin e
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified August 2005