Atherosclerosis

Clinical Trial Finder

Many patients with atherosclerosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

Conditions:   Prediabetic State;   Atherosclerosis;   Metformin
Interventions:   Drug: Metformin XR;   Drug: Placebo
Sponsor:   VA Office of Research and Development
Not yet recruiting - verified September 2016

Autologous CD133(+) Cells as an Adjuvant to Below the Knee Percutaneous Transluminal Angioplasty

Condition:   Peripheral Arterial Disease
Interventions:   Biological: G-CSF + CD133(+) cells;   Biological: G-CSF;   Procedure: percutaneous transluminal angioplasty (PTA);   Biological: Placebo infusion
Sponsor:   Shanghai 10th People's Hospital
Recruiting - verified September 2016

Safety and Feasibility of the Shockwave Lithoplasty® System for the Treatment of Peripheral Vascular Stenosis

Condition:   Peripheral Arterial Disease
Intervention:   Device: Shockwave Lithoplasty® System
Sponsor:   Shockwave Medical, Inc.
Recruiting - verified September 2016

Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRI

Conditions:   Cerebral Arterial Diseases;   Dissecting Aneurysm of Cerebral Artery;   Intimal Dissection
Intervention:   Other: High resolution magnetic resonance imaging for intracranial vessel walls
Sponsors:   Asan Medical Center;   Ministry of Health & Welfare, Korea;   Bracco Corporate
Recruiting - verified September 2016

Low Fat Plant-Based Supplemented Diet Effects on Risk Factors for Chronic Non-communicable Diseases

Conditions:   Hyperlipidemia;   Metabolic Syndrome X
Intervention:   Other: Low fat plant-based nutrition
Sponsor:   Barbara Jakše s.p.
Active, not recruiting - verified September 2016

Effects of Dietary Interventions on Serum and Macrophage Atherogenicity

Conditions:   Dietary Habits;   Serum; Disease;   Macrophage Atherogenicity;   Atherosclerosis
Interventions:   Dietary Supplement: monosaccharides;   Dietary Supplement: Disaccharides;   Dietary Supplement: Amino acids;   Dietary Supplement: Artificial Sweeteners;   Other: Control- water
Sponsor:   Rambam Health Care Campus
Recruiting - verified September 2016

Clinical Study of Passeo-18 Lux Balloon Catheter for the Treatment of Atherosclerotic Lesions(BIOLUX-P IV CHINA)

Condition:   Peripheral Arterial Disease
Intervention:   Device: Paclitaxel releasing angioplasty balloon
Sponsor:   Biotronik (Beijing) Medical Device Ltd.
Not yet recruiting - verified September 2016

Observational Study to Evaluate the BioMimics 3D Stent System: MIMICS-3D

Condition:   Peripheral Arterial Disease
Intervention:   Device: BioMimics 3D Stent
Sponsor:   Veryan Medical Ltd.
Recruiting - verified September 2016

Gestational Diabetes and Offspring's Cardiovascular Health: MySweetHeart Cohort

Conditions:   Cardiovascular Diseases;   Gestational Diabetes Mellitus
Intervention:   Other: GDM
Sponsor:   University of Lausanne Hospitals
Recruiting - verified September 2016

Clinical Features and Prevalence of Asymptomatic Peripheral Artery Disease in Patients With Type 1 Diabetes Mellitus

Conditions:   Type 1 Diabetes Mellitus;   Peripheral Artery Disease
Intervention:  
Sponsor:   Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Recruiting - verified May 2016

7 Year Follow-up Study of the DanRisk Population

Conditions:   Cardiovascular Disease;   Coronary Artery Calcification;   Atherosclerosis
Intervention:  
Sponsor:   Odense University Hospital
Completed - verified July 2016

Does Sildenafil Improve Endothelial Dysfunction in Rheumatoid Arthritis?

Conditions:   Arthritis, Rheumatoid;   Atherosclerosis
Interventions:   Drug: Sildenafil;   Other: Placebo
Sponsor:   University of Pittsburgh
Not yet recruiting - verified September 2016

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk Open-label Extension

Condition:   Dyslipidemia
Intervention:   Biological: Evolocumab
Sponsor:   Amgen
Recruiting - verified September 2016

A Study to Evaluate the Efficacy and Safety of TF0023 Spray on Subjects With Ischemic Strokes

Condition:   Ischemic Stroke
Intervention:   Drug: TF0023
Sponsor:   Techfields Inc
Recruiting - verified September 2016

Effect of Sitagliptin on Progression of Coronary Intermediate Lesion

Conditions:   Atherosclerosis;   Type 2 Diabetes Mellitus
Interventions:   Drug: Sitagliptin;   Drug: Placebo
Sponsor:   Li Bo
Recruiting - verified September 2016

Pilot Prospective Study of Two Methods of Revascularization of the Femoral Artery (SFA): Stenting in the SFA, and Stenting of the SFA, Supplemented by Fasciotomy in Hunter Channel.

Condition:   Atherosclerosis of the Peripheral Artery
Interventions:   Procedure: Angioplasty with stenting of the femoral artery;   Procedure: Angioplasty with stenting of the femoral artery, supplemented by fasciotomy in Hunter's channel
Sponsor:   Meshalkin Research Institute of Pathology of Circulation
Active, not recruiting - verified September 2016

Telmisartan Plus Exercise to Improve Functioning in Peripheral Artery Disease

Condition:   Peripheral Artery Disease
Interventions:   Behavioral: Supervised Treadmill Exercise Therapy;   Drug: Telmisartan;   Other: "No exercise" control group;   Drug: Placebo
Sponsors:   Northwestern University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified September 2016

Cost-utility Analysis of the Outpatient Versus Conventional Hospitalization in Treatment of Occlusive Arterial Disease

Condition:   Peripheral Arterial Disease
Intervention:   Procedure: Treatment of Occlusive Arterial Disease
Sponsors:   Nantes University Hospital;   Ministry of Health, France
Recruiting - verified September 2016

Effect of Beetroot Juice on Coronary Blood Flow and Walking Performance in PAD

Condition:   Peripheral Arterial Disease
Interventions:   Drug: Beetroot juice;   Drug: Beetroot juice placebo
Sponsors:   David N. Proctor;   Milton S. Hershey Medical Center;   Wake Forest School of Medicine
Recruiting - verified September 2016

A phase3 Study Measuring the Effect of Rosuvastatin 20 mg on Carotid Intima-Media Thickness in Chinese Subjects With Subclinical Atherosclerosis

Condition:   Atherosclerosis
Interventions:   Drug: Rosuvastatin;   Drug: Placebo
Sponsor:   AstraZeneca
Recruiting - verified September 2016

Real-World Registry Assessing the Clinical Use of the Lutonix 035 Drug Coated Balloon Catheter

Conditions:   Peripheral Arterial Disease;   Peripheral Vascular Diseases;   Arterial Occlusive Diseases
Intervention:   Device: PTA (Lutonix® 035 DCB Catheter)
Sponsor:   C. R. Bard
Active, not recruiting - verified September 2016

A Study of the Gut Barrier and Blood Vessel Inflammation in Individuals With and Without HIV

Condition:   HIV
Interventions:   Drug: Teduglutide;   Drug: Placebo
Sponsors:   Massachusetts General Hospital;   Ragon Institute of MGH, MIT and Harvard;   National Heart, Lung, and Blood Institute (NHLBI);   National Institutes of Health (NIH)
Recruiting - verified September 2016

Comparative Efficacy of Ticagrelor Versus Aspirin on Blood Viscosity in Peripheral Artery Disease Patients With Type 2 Diabetes

Conditions:   Peripheral Artery Disease;   Type 2 Diabetes
Interventions:   Drug: Aspirin;   Drug: Ticagrelor;   Drug: Aspirin Placebo;   Drug: Ticagrelor Placebo
Sponsor:   Icahn School of Medicine at Mount Sinai
Recruiting - verified September 2016

Genes Involved in Lipid Disorders

Condition:   Dyslipidemia
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified September 2016

Bard LifeStent and Lutonix DCB for Treatment of Long Lesions in Femoropopliteal Arteries

Condition:   Peripheral Artery Disease
Intervention:   Device: Lutonix Drug Coated Balloon
Sponsor:   C. R. Bard
Active, not recruiting - verified September 2016

RESveratrol To Improve Outcomes in oldeR pEople With PAD (the RESTORE Trial)

Condition:   Peripheral Arterial Disease
Interventions:   Drug: Resveratrol;   Drug: Placebo
Sponsors:   Northwestern University;   National Institute on Aging (NIA)
Completed - verified September 2016

Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia

Condition:   Eligible Men or Women Considered High Risk for Atherosclerotic Cardiovascular Disease (CVD)
Interventions:   Drug: Epanova® (omega-3 carboxylic acids);   Drug: corn oil control
Sponsors:   AstraZeneca;   Cleveland Clinic Coordinating Center for Clinical Research (C5R);   Quintiles, Inc.
Recruiting - verified September 2016

The Effect of Cranberry Extract Supplementation on Cardiovascular Risk Factors in Obese, Insulin Resistant Humans

Conditions:   Insulin Resistance;   Atherosclerosis
Interventions:   Dietary Supplement: Cranberry Extract;   Other: Placebo
Sponsors:   Pennington Biomedical Research Center;   Ocean Spray, Inc.
Active, not recruiting - verified September 2016

Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women

Conditions:   Menopause;   Aging
Interventions:   Drug: KUVAN;   Drug: Placebo;   Drug: Cetrotide;   Drug: Climara;   Drug: Placebo transdermal patch
Sponsors:   University of Colorado, Denver;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified September 2016

The Alberta Vascular Risk Reduction Community Pharmacy Project: RxEACH

Conditions:   Diabetes;   Chronic Kidney Disease;   Established Atherosclerotic Vascular Disease;   Framingham Risk Score >20%
Intervention:   Other: Advanced Care
Sponsors:   University of Alberta;   Alberta Health & Wellness;   Alberta Health Services;   Merck Frosst Canada Ltd.
Completed - verified September 2016

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified September 2016

Global Study of a Drug-coated Balloon to Treat Obstructive SFA and/or Popliteal Lesions

Condition:   Peripheral Arterial Disease
Intervention:   Device: CVI Paclitaxel-Coated PTA Balloon Catheter
Sponsor:   Spectranetics Corporation
Recruiting - verified September 2016

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention &Amp; Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute
Recruiting - verified September 2016

Patients With Intermittent Claudication Injected With ALDH Bright Cells

Conditions:   Peripheral Artery Disease;   Intermittent Claudication
Interventions:   Biological: ALD-301;   Biological: Placebo (vehicle)
Sponsors:   The University of Texas Health Science Center, Houston;   National Heart, Lung, and Blood Institute (NHLBI);   Aldagen;   Center for Cell and Gene Therapy, Baylor College of Medicine
Active, not recruiting - verified September 2016

Treadmill Exercise and GM-CSF Study to Improving Functioning in Peripheral Artery Disease (PAD)

Condition:   Peripheral Arterial Disease
Interventions:   Behavioral: Supervised Treadmill Exercise Therapy;   Other: Health education sessions (Control);   Drug: granulocyte macrophage colony stimulating factor (GM-CSF)
Sponsors:   Northwestern University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified September 2016

Contrast Ultrasound Perfusion Imaging in Peripheral Arterial Disease (PAD)

Condition:   Peripheral Arterial Disease
Intervention:  
Sponsor:   Oregon Health and Science University
Completed - verified September 2016

Laparoscopic Surgical Treatment of Aorto-iliac Occlusive Disease

Condition:   Aorto Iliac Occlusive Disease
Intervention:   Procedure: Laparoscopic vs open Ygraft
Sponsors:   Oslo University Hospital;   Sykehuset Ostfold;   Sorlandet Hospital HF
Completed - verified September 2016

The CASABLANCA Study: Catheter Sampled Blood Archive in Cardiovascular Diseases

Conditions:   Atherosclerosis;   Contrast Induced Nephropathy;   Renal Impairment
Intervention:  
Sponsor:   Massachusetts General Hospital
Completed - verified September 2016

Magnetic Resonance Angiography for Peripheral Arterial Disease (PAD)

Condition:   Peripheral Arterial Disease (PAD)
Interventions:   Drug: ferumoxytol;   Drug: ferumoxytol;   Drug: ferumoxytol
Sponsor:   AMAG Pharmaceuticals, Inc.
Active, not recruiting - verified September 2016

Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women

Conditions:   Arterial Stiffening;   Aging;   Menopause
Interventions:   Drug: GnRHant - Ganirelix acetate;   Drug: Transdermal estradiol patch;   Drug: Transdermal placebo patch
Sponsors:   University of Colorado, Denver;   National Institute on Aging (NIA)
Active, not recruiting - verified September 2016

ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study

Conditions:   Cardiovascular Disease;   Coronary Artery Calcification
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Recruiting - verified September 2016

Technical Development of Cardiovascular Magnetic Resonance Imaging

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified September 2016