Atherosclerosis

Clinical Trial Finder

Many patients with atherosclerosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

An Extension Trial of Inclisiran Compared to Evolocumab in Participants With Cardiovascular Disease and High Cholesterol

Conditions:   Atherosclerotic Cardiovascular Disease;   Symptomatic Atherosclerosis;   Type2 Diabetes;   Familial Hypercholesterolemia
Interventions:   Drug: Inclisiran;   Drug: Evolocumab
Sponsor:   The Medicines Company
Not yet recruiting - verified February 2017

Effect of Dry-weight Probing Guided by Lung-Ultrasound on Ambulatory Aortic Blood Pressure and Arterial Stiffness in Hemodialysis Patients (LUST Sub-Study)

Conditions:   Chronic Kidney Disease;   Hemodialysis;   Hypertension
Interventions:   Procedure: Extra-vascular lung water measurements by ultrasound;   Other: Standard protocol of fluid management in hemodialysis
Sponsors:   Carmine Zoccali;   Aristotle University of Thessaloniki, Thessaloniki, Greece;   CNR-IBIM Clinical Epidemiology of Renal Diseases and Hypertension Unit, Reggio, Italy;   University Clinical Centre of Maribor, Slovenia
Recruiting - verified February 2017

Pathogenic Mechanisms of Cancer and Cardiovascular Diseases

Conditions:   Pathogenesis;   Cardiovascular Diseases;   Cancer
Intervention:   Diagnostic Test: micro RNA
Sponsors:   Sakakibara Heart Institute;   Japanese Foundation for Cancer Research
Recruiting - verified February 2017

Short-term Perfusion Angiography Pilot Study (SPA)

Condition:   Peripheral Arterial Disease
Intervention:  
Sponsor:   Volcano Corporation
Recruiting - verified November 2016

Improve PAD PERformance With METformin

Condition:   Peripheral Artery Disease
Interventions:   Drug: Metformin;   Drug: Placebo
Sponsor:   Northwestern University
Not yet recruiting - verified February 2017

Platelet Acetyl Coenzyme A Carboxylase Phosphorylation in Coronary Artery Disease

Conditions:   Coronary Artery Disease;   Acute Coronary Syndrome;   Coronary Thrombosis
Intervention:   Diagnostic Test: Platelet Acetyl Coenzyme A Carboxylase analysis in CAD
Sponsor:   Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Completed - verified February 2017

OEIS Outcome Data Registry

Condition:   Peripheral Arterial Disease
Intervention:  
Sponsors:   Outpatient Endovascular and Interventional Society;   Syntactx
Recruiting - verified February 2017

Comparing TR Band to Statseal in Conjunction With TR Band

Conditions:   Arterial Occlusion;   Angina Pectoris;   Cardiovascular Diseases;   Atherosclerosis;   Hematoma;   Anticoagulant-Induced Bleeding;   Coronary Artery Disease
Interventions:   Device: StatSeal;   Device: TR Band
Sponsor:   VA Long Beach Healthcare System
Not yet recruiting - verified February 2017

Multiple Ascending Doses of MEDI6012 in Subjects With Stable Atherosclerotic Cardiovascular Disease

Conditions:   Atherosclerosis;   Cardiovascular Disease
Interventions:   Biological: MEDI6012;   Biological: Placebo
Sponsor:   MedImmune LLC
Recruiting - verified February 2017

A Real World Evaluation of the ELUVIA Stent in Subjects With Lesions Located in the Femoropopliteal Arteries

Conditions:   Arterial Occlusive Diseases;   Atherosclerosis;   Vascular Diseases;   Arteriosclerosis
Intervention:   Device: Peripheral stenting
Sponsor:   Boston Scientific Corporation
Recruiting - verified February 2017

Individualized Response to Vitamin D Treatment Study

Condition:   The Focus of the Study is to Determine Individual Genetic and Metabolic Characteristics That Modify the Response to Cholecalciferol Treatment
Interventions:   Dietary Supplement: Vitamin D3;   Drug: Placebo
Sponsor:   University of Washington
Enrolling by invitation - verified February 2017

Paclitaxel-coated Peripheral Stents Used in the Treatment of Femoropopliteal Stenoses

Condition:   Peripheral Arterial Disease (PAD)
Interventions:   Device: Zilver® Paclitaxel-Eluting Peripheral Stent;   Device: Zilver® Paclitaxel-Eluting Peripheral Stent with slower-dissolving polymer-free paclitaxel coating;   Device: Zilver® Paclitaxel-Eluting Peripheral Stent with higher-dose polymer-free paclitaxel coating
Sponsor:   Cook
Recruiting - verified February 2017

Machine Learning for Handheld Vascular Studies

Conditions:   Atherosclerosis;   Wounds and Injuries
Interventions:   Device: Non-invasive vascular testing;   Device: machine-learning algorithm
Sponsor:   Duke University
Recruiting - verified February 2017

Shockwave Medical Peripheral Lithoplasty System Study for PAD (Disrupt PAD III)

Condition:   Peripheral Arterial Disease
Interventions:   Device: Shockwave Lithoplasty® Peripheral Lithoplasty System;   Drug: Medtronic IN.PACT (DCB)
Sponsor:   Shockwave Medical, Inc.
Not yet recruiting - verified February 2017

Trial Comparing ELUVIA Versus Bare Metal Stent in Treatment of Superficial Femoral and/or Proximal Popliteal Artery

Conditions:   Arterial Occlusive Diseases;   Atherosclerosis;   Vascular Diseases;   Arteriosclerosis
Intervention:   Device: Peripheral stenting
Sponsor:   Boston Scientific Corporation
Recruiting - verified February 2017

Better Life by Nutrition During Adulthood

Condition:   Cardiovascular Risk Factor
Intervention:  
Sponsor:   University Hospital, Lille
Not yet recruiting - verified February 2017

Safety and Feasibility of the Shockwave Lithoplasty® System for the Treatment of Peripheral Vascular Stenosis

Condition:   Peripheral Arterial Disease
Intervention:   Device: Shockwave Lithoplasty® System
Sponsor:   Shockwave Medical, Inc.
Recruiting - verified February 2017

VascTrac Peripheral Arterial Disease (PAD) Study

Conditions:   Peripheral Artery Disease;   Intermittent Claudication
Intervention:   Behavioral: Physical activity levels
Sponsors:   Palo Alto Veterans Institute for Research;   Stanford Center for Clinical & Translational Research & Education;   Gore;   Abbott;   Cook
Not yet recruiting - verified February 2017

Humacyte's HAV for Femoro-Popliteal Bypass in Patients With PAD

Condition:   Peripheral Artery Disease
Intervention:   Biological: Human Acellular Vessel (HAV)
Sponsors:   Humacyte, Inc.;   Atlantic Research Group
Recruiting - verified February 2017

Efficacy, Safety, and Tolerability of Oral Ubrogepant in the Acute Treatment of Migraine

Condition:   Migraine, With or Without Aura
Interventions:   Drug: Ubrogepant;   Drug: Placebo-matching Ubrogepant
Sponsor:   Allergan
Recruiting - verified February 2017

LEADERS FREE II: BioFreedom™ Pivotal Study

Conditions:   Acute Coronary Syndrome;   High Bleeding Risk
Interventions:   Device: BioFreedom™ Drug Coated Coronary Stent System;   Drug: Dual Antiplatelet Therapy
Sponsor:   Biosensors Europe SA
Recruiting - verified February 2017

MyoVista Measurements in Patients With Atherosclerosis and CAD

Conditions:   Coronary Artery Disease (CAD);   Atherosclerosis
Intervention:   Device: MyoVista
Sponsors:   Los Angeles Biomedical Research Institute;   Heart Test Laboratories Inc.
Recruiting - verified August 2016

Body Fat Mass Association With Clinical Metabolic Profiles, Markers of Inflammation and Adipocytokines

Condition:   Overweight and Obesity
Intervention:  
Sponsor:   Tungs’ Taichung Metroharbour Hospital
Completed - verified February 2017

Prospective Study Evaluating the Interest of Long-term Cardiac Recording in Cerebral Infarction

Condition:   Neuropathology
Intervention:   Device: Uses of SpiderFlash monitor
Sponsor:   Groupe Hospitalier Paris Saint Joseph
Active, not recruiting - verified February 2017

Cocoa to Improve Walking Performance in Peripheral Artery Disease

Condition:   Peripheral Artery Disease
Interventions:   Drug: Cocoa;   Drug: Placebo
Sponsors:   Northwestern University;   National Institute on Aging (NIA)
Recruiting - verified February 2017

Trhombus Aspiration in Hyperglycemic ST-elevation myocardiAl InfarcTIon

Condition:   Hyperglycemia
Intervention:   Device: percutaneous coronary intervention
Sponsor:   Second University of Naples
Completed - verified February 2017

Serum Level of Myokines and Protein Energy Wasting, Inflammation and Atherosclerosis in Hemodialysis Patients

Condition:   Protein-energy; Imbalance
Intervention:  
Sponsor:   Tungs’ Taichung Metroharbour Hospital
Completed - verified February 2017

A Gene Therapy Study for Homozygous Familial Hypercholesterolemia (HoFH)

Condition:   Homozygous Familial Hypercholesterolemia
Intervention:   Biological: AAV directed hLDLR gene therapy
Sponsor:   University of Pennsylvania
Recruiting - verified January 2017

Compare I Pilot Study for the Treatment of Subjects With Symptomatic Femoropopliteal Artery Disease

Condition:   Peripheral Artery Disease
Interventions:   Device: Ranger Drug Eluting Balloon;   Device: In Pact Drug Eluting Balloon
Sponsor:   University of Leipzig
Recruiting - verified February 2017

Exercise Training in Individuals With Peripheral Arterial Disease

Conditions:   Peripheral Arterial Disease;   Intermittent Claudication
Intervention:   Other: Exercise training
Sponsor:   University Medical Centre Ljubljana
Recruiting - verified November 2016

Study of the Effect of Atorvastatin for Reducing Aging-related Complication in HIV-infected Patients Older Than 45 Years Receiving a Protease Inhibitor-based Regimen Versus a Raltegravir-based Regimen

Condition:   Aging-related Inflammation in HIV-infected Patients
Interventions:   Drug: Raltegravir;   Drug: PI-based regimen;   Drug: Atorvastatin
Sponsor:   Fundacio Lluita Contra la SIDA
Active, not recruiting - verified February 2017

ELUVIA™ Drug-eluting Stent Versus Zilver® PTX® Stent

Condition:   Atherosclerosis of Native Arteries of the Extremities
Interventions:   Device: ELUVIA (Stent Implantation);   Device: Zilver PTX (Stent Implantation)
Sponsor:   Boston Scientific Corporation
Active, not recruiting - verified February 2017

iPhone App Compared to Standard RR-measurement

Conditions:   Hypertension;   Blood Pressure
Interventions:   Device: cuff device (Omron HBP-1300-E Pro);   Device: iPhone 4s
Sponsors:   Jens Eckstein;   Preventicus GmbH
Completed - verified February 2017

Low InTensity Exercise Intervention in PAD

Condition:   Peripheral Artery Disease
Interventions:   Behavioral: Exercise;   Other: Attention control
Sponsors:   Northwestern University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified February 2017

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Recruiting - verified February 2017

"All Comers" Post Market Clinical Follow-up (PMCF) With Multi-LOC for flOw liMiting Outcomes

Condition:   Peripheral Arterial Occlusive Disease
Intervention:   Device: VascuFlex Multi-LOC®
Sponsors:   B. Braun Melsungen AG;   Diakonissenkrankenhaus Mannheim
Active, not recruiting - verified February 2017

First-in-man Study of Titanium-Nitride Coated Woven-nitinol Peripheral Arterial Stent

Condition:   Peripheral Arterial Disease
Intervention:   Device: GoldenFlow Stent
Sponsors:   Chinese University of Hong Kong;   Lifetech Scientific (Shenzhen) Co., Ltd.
Recruiting - verified February 2017

Patient Centered Home Exercise Program for Peripheral Artery Disease

Condition:   Peripheral Artery Disease
Intervention:   Behavioral: Home-based exercise intervention
Sponsors:   Northwestern University;   Patient-Centered Outcomes Research Institute
Recruiting - verified February 2017

Novel Treatment of Intermittent Claudication in Patients With Peripheral Arterial Disease Using Danshen Gegen (D&G) Capsule

Conditions:   Peripheral Arterial Disease;   Intermittent Claudication
Interventions:   Drug: Danshen Gegen Capsule;   Drug: Placebo
Sponsor:   Chinese University of Hong Kong
Recruiting - verified February 2017

DNA Damage & Repair Proteins In Patients With Atherosclerotic Coronary Artery Disease

Condition:   Coronary Atherosclerosis
Intervention:  
Sponsors:   University of Surrey;   Ashford and St. Peter's NHS Trust
Completed - verified February 2017

Non-invasive Computer-Aided Phenotyping of Vasculopathy

Conditions:   Carotid Atherosclerosis;   Peripheral Arterial Disease
Intervention:  
Sponsor:   Elucid Bioimaging Inc.
Recruiting - verified February 2017

Evaluation of a Non-Invasive Electrocardiogram-Assisted Blood Pressure Monitor

Conditions:   Hypertension;   Atrial Fibrillation;   Obesity;   Heart Failure;   Atherosclerosis
Intervention:  
Sponsor:   Health Parametrics Inc.
Terminated - verified February 2017

The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Terminated - verified February 2017

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Terminated - verified February 2017

Correlation Between Coronary and Carotid Atherosclerotic Disease and Links With Clinical Outcomes

Condition:   Vascular Disease
Intervention:  
Sponsor:   Montreal Heart Institute
Completed - verified February 2017

Zilver® PTX® V Clinical Study

Condition:   Peripheral Arterial Disease
Intervention:   Device: Zilver® PTX® Drug-Eluting Peripheral Stent
Sponsor:   Cook
Active, not recruiting - verified February 2017

Gene Analysis and Treatment Optimization in Chinese Homozygous Familial Hypercholesterolemia

Condition:   Homozygous Familial Hypercholesterolemia
Interventions:   Genetic: Gene analysis;   Other: Historical data of lipid-lowering drug administration;   Other: Historical data of plasma lipids, xanthoma changes
Sponsor:   Central South University
Completed - verified February 2017

Evaluation of the Safety and Efficacy of a Vascular Prosthesis as an Above-Knee Bypass Graft in Patients With PAD

Conditions:   Peripheral Arterial Disease;   Peripheral Vascular Disease
Intervention:   Device: HAVG graft implantation
Sponsors:   Humacyte, Inc.;   FGK Clinical Research Sp. zo.o.;   FGK Clinical Research GmbH
Active, not recruiting - verified February 2017

Study of Human Placenta-derived Cells (PDA002) to Evaluate the Safety and Effectiveness in Subjects With PAD and DFU

Conditions:   Peripheral Arterial Disease;   Diabetic Foot
Interventions:   Biological: 3 x 10^6 cells;   Biological: 10 x 10^6 cells;   Biological: 30 x 10^6 cells;   Biological: 100 x 10^6 cells
Sponsor:   Celgene
Completed - verified February 2017

The Psoriasis, Atherosclerosis, and Cardiometabolic Disease Initiative (PACI)

Conditions:   Metabolic Disease;   Cardiovascular Disease;   Inflammation
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified January 24, 2017

Open-label Pilot Study to Assess the Use of Magic Foot™ in the Improvment of Parameters in Subject With Foot Symptoms

Conditions:   Diabetes;   Peripheral Vascular Disease
Intervention:   Device: Magic Foot™
Sponsor:   Yaffa Golan, Ltd.
Completed - verified February 2017

Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

Condition:   Prevention &Amp; Control
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Aspirin;   Drug: Aspirin placebo;   Drug: Rivaroxaban placebo;   Drug: Pantoprazole
Sponsors:   Bayer;   Hamilton Health Sciences Corporation, Population Health Research Institute;   Janssen Research & Development, LLC
Recruiting - verified February 2017

Treadmill Exercise and GM-CSF Study to Improving Functioning in Peripheral Artery Disease (PAD)

Condition:   Peripheral Arterial Disease
Interventions:   Behavioral: Supervised Treadmill Exercise Therapy;   Other: Health education sessions (Control);   Drug: granulocyte macrophage colony stimulating factor (GM-CSF)
Sponsors:   Northwestern University;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified February 2017

Assessment With CCTA and MRI in Asymptomatic Patients With Type 2 Diabetes for Detection of Unrecognized Myocardial Scar in Subclinical Coronary Atherosclerosis

Conditions:   Type 2 Diabetes Mellitus;   Coronary Atherosclerosis
Intervention:   Drug: Iobitridol
Sponsor:   Guerbet
Active, not recruiting - verified February 2017

Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression

Conditions:   Atherosclerosis;   Hypercholesterolemia
Interventions:   Drug: Statin Drugs;   Other: HMG-CoA Reductase Inhibitors
Sponsor:   National Institutes of Health Clinical Center (CC)
Completed - verified March 21, 2016

The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Darapladib 160 mg;   Drug: Placebo;   Other: Standard Therapy
Sponsors:   GlaxoSmithKline;   The TIMI Study Group
Completed - verified February 2017

Effects of Omega-3 Fatty Acids and Menaquinone-7 on Thrombotic Tendency

Condition:   Atherosclerosis
Interventions:   Dietary Supplement: menaquinone-7;   Dietary Supplement: fish oil;   Dietary Supplement: krill oil
Sponsor:   Maastricht University Medical Center
Completed - verified March 2009

Vascular Aging: The Link That Bridges Age to Atherosclerosis (The VALIDATE Study)

Conditions:   Atherosclerosis;   Cardiovascular Disease;   Vascular Diseases
Intervention:  
Sponsor:   National Institute on Aging (NIA)
Active, not recruiting - verified January 26, 2017