Atherosclerosis

Clinical Trial Finder

Many patients with atherosclerosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Remote Ischemic Conditioning for Avoiding Recurrence of Symptomatic Intracranial Atherosclerotic Stenosis (sICAS)

Condition:   Intracranial Atherosclerosis
Interventions:   Device: Doctormate® (200mmHg);   Device: Doctormate® (60mmHg)
Sponsor:   Ji Xunming
Not yet recruiting - verified August 2015

Sitagliptin Therapy and Kinetics of Inflammatory Markers

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Sitagliptin;   Drug: Placebo
Sponsors:   Laval University;   Merck Sharp & Dohme Corp.
Completed - verified August 2015

Evaluation of ARI-3037MO, to Suppress LDL Cholesterol in Patients With Dyslipidemia

Condition:   Hyperlipidemia
Intervention:   Drug: ARI-3037MO
Sponsor:   Arisaph Pharmaceuticals Inc
Recruiting - verified August 2015

The Effect of Blood Pressure on Cerebral Perfusion During Vascular Surgery

Conditions:   Anesthesia;   Peripheral Arterial Diseases
Interventions:   Other: MAP maintained at 80 mmHg;   Other: MAP maintained at 60 mmHg
Sponsor:   Rigshospitalet, Denmark
Recruiting - verified August 2015

Attentional Capacity and Working Memory in Coronary Artery Disease Patients: Impact of the Presence of a Sleep Apnea Syndrome and Chronic Effects of Treatment With CPAP

Conditions:   Obstructive Sleep Apnea;   Acute Coronary Syndrome
Intervention:   Device: CPAP treatment
Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
Recruiting - verified August 2015

A Study to Evaluate the Efficacy and Safety of Rosuvastatin in the Treatment of the Carotid Atherosclerotic Plaques

Condition:   Carotid Atherosclerosis
Interventions:   Drug: Rosuvastatin (5mg,10mg,20mg);   Drug: Rosuvastatin 5mg
Sponsors:   Wei Liu;   Xue-Qiao Zhao, MD, FACC. University of Washington;   AstraZeneca;   Beijing Clinstech-med consulting Co., Ltd
Recruiting - verified August 2015

Heart Rate Variability (HRV) Testing Compared With Exercise Stress Test in Hospitalized Patients With Chest Pain

Conditions:   Angina Pectoris;   Ischemic Heart Disease
Intervention:   Other: Heart rate monitor
Sponsor:   Meir Medical Center
Recruiting - verified August 2015

Clinical Cohort Study On The Relation Among Prescription, Syndrome and Disease of Turbid Phlegm and Blood Stasis for Coronary Heart Disease

Condition:   Coronary Artery Disease
Interventions:   Drug: Danlou Tablets;   Drug: Tongmai Yangxin Pills
Sponsor:   Tianjin University of Traditional Chinese Medicine
Recruiting - verified August 2015

Tack Optimized Balloon Angioplasty Study of the Tack Endovascular System™ in Femoropoliteal Arteries

Condition:   Peripheral Artery Disease
Intervention:   Device: Tack Endovascular System
Sponsor:   Intact Vascular
Not yet recruiting - verified August 2015

An Investigation to Evaluate an Over-The-Wire FFR Infusion Microcatheter (HYPEREM™IC) for Measuring Fractional Flow Reserve (FFR)

Condition:   Coronary Artery Disease
Intervention:   Device: FFR Infusion Microcatheter and standard intra-venous (IV) infusion
Sponsor:   Diasolve Ltd
Not yet recruiting - verified August 2015

Comparison of Optical Coherence Tomographic Findings After Balloon Angioplasty With Two Different Paclitaxel-Coated Balloons for the Treatment of In-Stent Restenosis in Drug-Eluting Stents

Condition:   Coronary Artery Disease
Interventions:   Device: balloon angioplasty with Pantera Lux;   Device: balloon angioplasty with SeQuent Please
Sponsor:   Yonsei University
Not yet recruiting - verified August 2015

CER-001 Atherosclerosis Regression ACS Trial

Condition:   Acute Coronary Syndromes
Interventions:   Drug: CER-001;   Drug: Placebo
Sponsors:   Cerenis Therapeutics, SA;   South Australian Health and Medical Research Institute
Recruiting - verified August 2015

Pilot Study of the Fantom Bioresorbable Scaffold (FANTOM I)

Condition:   Coronary Artery Disease
Intervention:   Device: Fantom Scaffold
Sponsor:   REVA Medical, Inc.
Active, not recruiting - verified August 2015

Evaluation of Antiplatelet Effects and Safety of Intraoperative Administration of Ticagrelor Versus Clopidogrel

Condition:   Coronary Disease
Interventions:   Drug: Ticagrelor;   Drug: Clopidogrel
Sponsor:   Yongjian Wu
Recruiting - verified August 2015

FAST Feasibility Study

Condition:   Coronary Artery Disease
Intervention:   Device: Boston Scientific Fully Absorbable Scaffold
Sponsor:   Boston Scientific Corporation
Recruiting - verified August 2015

"All Comers" Post Market Clinical Follow-up (PMCF) With Multi-LOC for flOw liMiting Outcomes

Condition:   Peripheral Arterial Occlusive Disease
Intervention:   Device: Multi-LOC®
Sponsors:   B. Braun Melsungen AG;   Diakonissenkrankenhaus Mannheim
Not yet recruiting - verified August 2015

Natural History of Atherosclerosis in Real-World Patients Underwent Computed Tomography Angiography

Conditions:   Coronary Atherosclerosis;   Coronary Artery Disease;   Radiocontrast-induced Thyroid Dysfunction;   Contrast-induced Nephropathy
Interventions:   Radiation: Coronary computed tomography angiography;   Radiation: Quantitative coronary angiography
Sponsors:   Ural Medical University ;   Ural Institute of Cardiology;   De Haar Research Foundation
Enrolling by invitation - verified August 2015

Clear-Road Trial, Investigating the Efficacy of the RoadSaver Stent

Condition:   Peripheral Arterial Disease
Intervention:   Device: RoadSaver stent
Sponsor:   Flanders Medical Research Program
Recruiting - verified August 2015

A Study to Obtain Additional Information on the Use of CorMatrix® CanGaroo ECM® Envelope

Condition:   Coronary Disease
Intervention:   Device: CorMatrix CanGaroo ECM Envelope
Sponsor:   CorMatrix
Not yet recruiting - verified August 2015

Identification of the Blood Microbiota in Patient Suffering From Myocardial Infraction

Conditions:   Coronary Disease;   Myocardial Infarction
Intervention:  
Sponsor:   University Hospital, Toulouse
Recruiting - verified August 2015

Differential Effect of High (200μg/kg/Min) Adenosine Dose on Fractional Flow Reserve in Patients Presenting Variation of FFR ≥0.05 During the Usual Dose of Adenosine Infusion (140μg/kg/Min).

Condition:   Coronary Artery Disease
Intervention:   Drug: Adenosine infusion at 200μg/Kg/min
Sponsor:   University of Patras
Recruiting - verified August 2015

Role of PPAR-y Anonists in Immunomodulation and Vascular Prevention in SLE (PPAR-SLE)

Condition:   Systemic Lupus Erthematosus
Interventions:   Radiation: PET/CT;   Drug: Pioglitazone;   Procedure: Vascular function studies
Sponsor:   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified December 2014

Randomized Evaluation of Anagliptin Versus Sitagliptin On Low-density lipoproteiN Cholesterol in Diabetes Trial

Conditions:   Dipeptidyl-Peptidase 4 Inhibitors;   LDL Cholesterol;   Glycosylated Hemoglobin;   Diabetes Mellitus;   Coronary Disease
Interventions:   Drug: Anagliptin;   Drug: Sitagliptin
Sponsor:   Institute for Clinical Effectiveness, Japan
Recruiting - verified August 2015

Chest Pain Perception and Capsaicin Sensitivity in Patients With Acute Cardiac Ischemia

Condition:   Chest Pain
Intervention:   Drug: Capsaicin
Sponsor:   Bassett Healthcare
Active, not recruiting - verified August 2015

Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment

Conditions:   Cardiovascular Disease;   Atherosclerosis
Interventions:   Other: MRI;   Other: PET/MRI;   Other: Laboratory blood test
Sponsor:   Cedars-Sinai Medical Center
Recruiting - verified August 2015

Improvement of Subjective Well-Being by Ranolazine Among Unrevascularized Chronic Stable Coronary Artery Disease Patients

Condition:   Angina
Interventions:   Drug: Ranolazine;   Drug: Sugar pill
Sponsors:   North Florida Foundation for Research and Education;   Gilead Sciences
Recruiting - verified August 2015

Efficacy and Safety of Intramuscular PDA-002 in Subjects Who Have Diabetic Foot Ulcer With Peripheral Arterial Disease

Conditions:   Peripheral Arterial Disease;   Diabetic Foot
Interventions:   Biological: 3 x 10^6 cells;   Biological: 10 x 10^6 cells;   Biological: 30 x 10^6 cells;   Other: Placebo
Sponsor:   Celgene Corporation
Recruiting - verified August 2015

Trial of ARI-3037MO to Reduce Triglyceride Levels in Adults With Severe (≥500 mg/dl) Hypertriglyceridemia

Condition:   Hypertriglyceridemia
Interventions:   Drug: ARI-3037MO;   Drug: Placebo
Sponsors:   Arisaph Pharmaceuticals Inc;   Harvard Clinical Research Institute
Recruiting - verified August 2015

PLATINUM Diversity

Conditions:   Atherosclerosis;   Coronary Artery Disease
Intervention:   Device: Percutaneous coronary intervention (Promus PREMIER)
Sponsor:   Boston Scientific Corporation
Active, not recruiting - verified August 2015

A Study of Evacetrapib (LY2484595) in Participants With High Cholesterol

Condition:   Hyperlipidemia
Interventions:   Drug: Evacetrapib;   Drug: Atorvastatin;   Drug: Ezetimibe;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Recruiting - verified August 2015

Impact of Breathing Maneuvers on the Oxygenation Supply of the Heart Assessed With MRI in Patients With Coronary Artery Disease

Condition:   Coronary Artery Disease
Interventions:   Drug: Oxygen;   Other: Hyperventilation Breath-hold (HVBH);   Other: HVBH with Oxygen
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified August 2015

Walking Effect of Long Term Ticagrelor in Subjects With PAD Who Have Undergone EVR

Condition:   Peripheral Artery Disease (PAD)
Interventions:   Drug: Ticagrelor;   Drug: Comparator
Sponsors:   AstraZeneca;   CPC Clinical Research
Recruiting - verified August 2015

Study Of Costs Realized After Percutaneous Coronary intervenTion Employing Same Day Discharge

Condition:   Coronary Artery Disease
Intervention:   Procedure: Same day discharge
Sponsors:   Saint Joseph Mercy Health System;   Michigan Heart;   Blue Cross Blue Shield of Michigan Foundation
Terminated - verified August 2015

Non-invasive Computer-Aided Phenotyping of Vasculopathy

Conditions:   Carotid Atherosclerosis;   Peripheral Arterial Disease
Intervention:  
Sponsor:   Elucid Bioimaging Inc.
Recruiting - verified August 2015

Using Feedback Reports to Improve Medication Adherence

Conditions:   Coronary Artery Disease;   Adherence
Interventions:   Behavioral: Individual Feedback;   Behavioral: Feedback Friend
Sponsor:   Philadelphia Veterans Affairs Medical Center
Active, not recruiting - verified August 2015

Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia

Condition:   Eligible Men or Women Considered High Risk for Atherosclerotic Cardiovascular Disease (CVD)
Interventions:   Drug: Epanova® (omega-3 carboxylic acids);   Drug: corn oil control
Sponsors:   AstraZeneca;   The Cleveland Clinic
Recruiting - verified August 2015

Prospective Assessment of Efficacy and Safety of Drug Eluting Stents

Condition:   Coronary Heart Disease
Intervention:  
Sponsor:   China National Center for Cardiovascular Diseases
Completed - verified August 2015

Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women

Conditions:   Menopause;   Aging
Interventions:   Drug: KUVAN;   Drug: Placebo;   Drug: Cetrotide;   Drug: Climara;   Drug: Placebo transdermal patch
Sponsors:   University of Colorado, Denver;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified August 2015

Post Market Surveillance Study of the Wingspan Stent System

Condition:   Intracranial Atherosclerosis
Intervention:   Device: Wingspan Stent System
Sponsor:   Stryker Neurovascular
Recruiting - verified August 2015

Offset of Ticagrelor's Effect on Endothelial Function as Assessed With Peripheral Arterial Tonometry (EndoPAT Assay)

Conditions:   Coronary Artery Disease;   Endothelial Function
Intervention:   Device: Peripheral arterial tonometry  (EndoPAT)
Sponsor:   University of Patras
Completed - verified August 2015

Differential Effect of Ticagrelor Versus Prasugrel Maintenance Dose on Endothelial Function of Peripheral Vessels in Patients With Coronary Artery Disease

Conditions:   Coronary Artery Disease;   Endothelial Function
Interventions:   Drug: Ticagrelor;   Drug: Prasugrel
Sponsor:   University of Patras
Recruiting - verified August 2015

Investigations of the Effect of MK-7 on Bone and Glucose Metabolism and Arterial Calcification

Condition:   Metabolic Bone Disorder
Interventions:   Dietary Supplement: K2 vitamin;   Dietary Supplement: Placebo
Sponsors:   University of Aarhus;   Axellus
Active, not recruiting - verified August 2015

Cognition and Exercise Training

Conditions:   Metabolic Syndrome;   Coronary Heart Disease;   Chronic Heart Failure
Interventions:   Other: high intensity interval training (HIIT);   Other: moderate intensity continuous exercise training
Sponsor:   Montreal Heart Institute
Recruiting - verified August 2015

A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure

Conditions:   Heart Failure;   Coronary Artery Disease
Interventions:   Drug: Rivaroxaban;   Drug: Placebo;   Other: Standard of care for heart failure and coronary artery disease
Sponsors:   Janssen Research & Development, LLC;   Bayer
Recruiting - verified August 2015

Alpha-lipoic Acid Reduces Left Ventricular Mass in Normotensive Type 2 Diabetic Patients With Coronary Artery Disease

Conditions:   Type 2 Diabetes;   Coronary Artery Disease;   Left Ventricular Mass
Intervention:   Drug: alpha-lipoic acid
Sponsor:   Wuhan General Hospital of Guangzhou Military Command
Completed - verified August 2015

Surgical Pulmonary Vein Isolation Efficiency Study

Conditions:   Paroxysmal Atrial Fibrillation;   Coronary Artery Disease
Interventions:   Procedure: CABG, AVR or CABG+AVR and PVI;   Procedure: CABG, AVR or CABG+AVR
Sponsor:   Kuopio University Hospital
Terminated - verified August 2015

Drug Eluting Balloon for Prevention of Constrictive Remodeling

Conditions:   Coronary Disease;   Diabetes Mellitus
Interventions:   Device: Paclitaxel coated balloon catheter;   Device: uncoated balloon catheter "sprinter legend"
Sponsor:   Prof. Dr. med. Christoph Hehrlein
Recruiting - verified August 2015

China PEACE-Prospective PCI Study

Condition:   Coronary Heart Disease
Intervention:  
Sponsors:   China National Center for Cardiovascular Diseases;   Ministry of Health, China
Completed - verified August 2015

China PEACE-Prospective AMI Study

Condition:   Coronary Heart Disease
Intervention:  
Sponsors:   China National Center for Cardiovascular Diseases;   Ministry of Health, China
Completed - verified August 2015

Safety and Effectiveness of Intra-coronary Nitrite in Acute Myocardial Infarction

Conditions:   Myocardial Infarction;   Reperfusion Injury;   Myocardial Ischemia;   Cardiovascular Diseases
Interventions:   Drug: Sodium Nitrite;   Drug: Sodium Chloride Placebo
Sponsors:   Barts & The London NHS Trust;   Queen Mary University of London
Active, not recruiting - verified July 2015

Coronary Hybrid Revascularisation Study

Condition:   Significant Coronary Artery Disease
Intervention:   Procedure: Combined CABG and PCI
Sponsor:   Aarhus University Hospital Skejby
Active, not recruiting - verified August 2015

Assessment of the Role of the Growth Hormone (GH) Onthe Intestinal Triglyceride-rich-lipoproteins (TRL) Metabolism

Condition:   Atherosclerotic Cardiovascular Disease
Interventions:   Drug: Growth Hormone;   Other: interruption of the traitment with growth hormone
Sponsor:   Assistance Publique Hopitaux De Marseille
Recruiting - verified August 2015

Efficacy of Prednisone in Patients With Severe Systemic Atheroembolism (Cholesterol Cristal Embolism)

Condition:   Cholesterol Embolism Systemic
Interventions:   Drug: prednisone;   Other: placebo
Sponsors:   University Hospital, Toulouse;   Ministry of Health, France
Recruiting - verified August 2015

METHOD - Bone Marrow Derived Mononuclear Cells in Chronic Ischemic Disease

Condition:   Chronic Ischemic Heart Disease
Interventions:   Other: intramyocardial injection of BM cells;   Other: intramyocardial / intracoronary injection of BM cells;   Other: Best medical therapy
Sponsor:   Cardiocentro Ticino
Terminated - verified August 2015

Stress Echocardiography and Heart Computed Tomography (CT) Scan in Emergency Department Patients With Chest Pain

Conditions:   Chest Pain;   Angina;   Angina Pectoris;   Coronary Artery Disease
Interventions:   Procedure: Stress Echocardiography;   Procedure: Coronary CT Angiography
Sponsors:   Montefiore Medical Center;   American Heart Association
Recruiting - verified August 2015

Bone Marrow Aspirate Concentrate (BMAC) for Treatment of Critical Limb Ischemia (CLI)

Condition:   Critical Limb Ischemia
Interventions:   Device: BMAC injection;   Device: Placebo injection
Sponsor:   Harvest Technologies
Active, not recruiting - verified August 2015

A Survey to Evaluate the Rate of Abnormal Glucose Tolerance Among Hong Kong Chinese Subjects With Coronary Heart Disease

Conditions:   Coronary Heart Disease;   Diabetes Mellitus
Intervention:  
Sponsor:   Chinese University of Hong Kong
Withdrawn - verified August 2015

Study Comparing CT Scan and Stress Test in Diagnosing Coronary Artery Disease in Patients Hospitalized for Chest Pain

Conditions:   Coronary Artery Disease;   Angina Pectoris;   Unstable Angina;   Acute Coronary Syndrome
Interventions:   Procedure: Coronary Computed Tomography Angiography;   Procedure: Stress Nuclear Myocardial Perfusion Imaging
Sponsors:   Montefiore Medical Center;   American Heart Association;   Albert Einstein College of Medicine of Yeshiva University
Completed - verified August 2015

Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese Women

Conditions:   Atherosclerosis;   Diabetes Mellitus;   Obesity;   Dyslipidemia;   Hypertension
Interventions:   Behavioral: Exercise;   Behavioral: Weight Loss
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified August 2015

Database Registry of the Intermountain Heart Collaborative Study

Conditions:   Coronary Artery Disease;   Electrophysiology;   Cardiovascular Disease
Intervention:  
Sponsor:   Intermountain Health Care, Inc.
Recruiting - verified August 2015

Carotid Plaque Regression With Statin Treatment Assessed by High Field Magnetic Resonance Imaging (MRI)

Condition:   Carotid Atherosclerosis
Intervention:  
Sponsor:   Medical College of Wisconsin
Withdrawn - verified August 2015

Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen

Condition:   Arthritis, Rheumatoid
Interventions:   Drug: celecoxib;   Drug: Ibuprofen;   Drug: Naproxen
Sponsors:   Pfizer;   The Cleveland Clinic
Active, not recruiting - verified August 2015

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