Atherosclerosis

Clinical Trial Finder

Many patients with atherosclerosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

DD2-Coronary Plaque Morphology and Plaque Progression

Conditions:   Diabetes;   Plaque;   Atherosclerosis
Intervention:   Radiation: Cardiac CT
Sponsors:   Sydvestjysk Hospital;   The Danish Diabetes Academy supported by the Novo Nordisk Foundation;   University of Southern Denmark;   Department of Regional Health Research - Center Southwest;   Edith and Vagn Hedegaard Jensens Foundation;   Karola Jørgensens Foundation and Foundation for Cardiology in Southwest Denmark.
Not yet recruiting - verified January 2017

Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease

Conditions:   Adverse Effect;   Atherosclerosis, Coronary;   Insulin Resistance Syndrome
Interventions:   Drug: Pioglitazone 15 mg Tablet;   Drug: Isosorbide Dinitrate 10Mg Tablet;   Drug: Acetylsalicylic Acid 75Mg Tablet;   Drug: Bisoprolol Fumarate 2.5 MG Oral Tablet;   Drug: Rosuvastatin Calcium 20 MG Oral Tablet;   Drug: ramipril 5 MG
Sponsor:   Ukrainian Medical Stomatological Academy
Completed - verified January 2017

Screening Protocol for a Gene Therapy Trial in Subjects With Homozygous Familial Hypercholesterolemia

Condition:   Hypercholesterolemia, Familial
Intervention:  
Sponsor:   University of Pennsylvania
Recruiting - verified January 2017

Long Superficial Femoral Artery Stenting With SuperA Interwoven Nitinol Stents

Condition:   Atherosclerosis Obliterans
Intervention:   Device: Endovascular treatment for PAD during medical care (SuperA stent (Abbott))
Sponsors:   Nantes University Hospital;   Abbott
Recruiting - verified January 2017

Coronary Artery Plaque Burden and Morphology in Type 2 Diabetes Mellitus.

Conditions:   Type2 Diabetes;   Atherosclerosis;   Plaque, Atherosclerotic;   Plaque Vulnerability;   Diabetes Complications;   Microalbuminuria;   Coronary Computed Tomography Angiography
Intervention:  
Sponsor:   Svendborg Hospital
Recruiting - verified January 2017

Angiosome Perfusion After Tibial Bypass

Condition:   Peripheral Arterial Disease
Intervention:   Drug: Indocyanine Green
Sponsor:   University Hospital Erlangen
Completed - verified January 2017

Soundbite Crossing System Peripheral First in Man (SCSPFIM)

Condition:   Peripheral Artery Disease
Intervention:   Device: SoundBite Crossing System
Sponsor:   SoundBite Medical Solutions, Inc.
Recruiting - verified January 2017

Mirabegron and Brown Adipose Tissue

Condition:   Obesity
Interventions:   Drug: Mirabegron;   Other: Short term mild cooling;   Drug: Placebo Oral Capsule
Sponsor:   Ingrid Jazet
Recruiting - verified January 2017

Evaluation of Long-Term Efficacy of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia at High Cardiovascular Risk

Conditions:   Hypercholesterolemia;   Atherosclerotic Cardiovascular Disease
Interventions:   Drug: bempedoic acid;   Drug: placebo
Sponsor:   Esperion Therapeutics
Recruiting - verified January 2017

Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women

Conditions:   Estrogen Deficiency;   Cardiovascular Disease (CVD);   Hypothalamic Amenorrhea
Interventions:   Drug: 17beta Estradiol;   Drug: Transdermal placebo patch;   Drug: Progesterone;   Drug: Placebo Pill
Sponsor:   Cedars-Sinai Medical Center
Not yet recruiting - verified January 2017

Platelet Activation and Reactivity in Acute Exacerbations of COPD

Condition:   COPD Exacerbation
Intervention:   Other: Blood is drawn
Sponsor:   Radboud University
Not yet recruiting - verified November 2016

Alirocumab and Reverse Cholesterol Transport

Conditions:   Atherosclerosis;   Coronary Heart Disease
Interventions:   Drug: Alirocumab;   Drug: Placebos
Sponsor:   Richard E. Ostlund Jr., MD
Not yet recruiting - verified January 2017

Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia and Statin Intolerant

Conditions:   Hypercholesterolemia;   Atherosclerotic Cardiovascular Disease;   Statin Adverse Reaction
Interventions:   Drug: bempedoic acid;   Other: placebo
Sponsor:   Esperion Therapeutics
Recruiting - verified January 2017

IN.PACT BTK Randomized Study to Assess Safety and Efficacy of IN.PACT 014 vs. PTA

Conditions:   Critical Limb Ischemia;   Peripheral Arterial Disease
Interventions:   Device: DCB;   Device: PTA
Sponsor:   Medtronic Endovascular
Recruiting - verified January 2017

The Effect of Anacetrapib on Vascular Function and Arterial Stiffness

Conditions:   Atherosclerotic Cardiovascular Disease;   Vascular Disease
Interventions:   Drug: Anacetrapib;   Drug: Statin;   Drug: Placebo
Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   British Heart Foundation Cambridge Centre of Excellence
Recruiting - verified January 2017

Observational Study to Evaluate the BioMimics 3D Stent System: MIMICS-3D

Condition:   Peripheral Arterial Disease
Intervention:   Device: BioMimics 3D Stent
Sponsor:   Veryan Medical Ltd.
Recruiting - verified January 2017

Efficacy, Safety, and Tolerability of Oral Ubrogepant in the Acute Treatment of Migraine

Condition:   Migraine, With or Without Aura
Interventions:   Drug: Ubrogepant;   Drug: Placebo-matching Ubrogepant
Sponsor:   Allergan
Recruiting - verified January 2017

LEADERS FREE II: BioFreedom™ Pivotal Study

Conditions:   Acute Coronary Syndrome;   High Bleeding Risk
Interventions:   Device: BioFreedom™ Drug Coated Coronary Stent System;   Drug: Dual Antiplatelet Therapy
Sponsor:   Biosensors Europe SA
Not yet recruiting - verified January 2017

An Efficacy and Safety Study to Evaluate Ranger DEB for BTK Angioplasty in Patients With CLI (RANGER-BTK)

Conditions:   Lower Limb Ischemia;   Peripheral Vascular Diseases
Intervention:   Device: Ranger SL DEB
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Boston Scientific Corporation
Recruiting - verified January 2017

Carotid Atherosclerosis : Innovative Imaging Biomarkers. Study Case-control

Condition:   Carotid Stenosis
Intervention:   Device: HITS quantification, Ultrasound examinations, High Resolution MRI
Sponsors:   Hospices Civils de Lyon;   Fondation de France;   Bracco Imaging S.p.A.
Recruiting - verified January 2017

Effects of Eplerenone on Cardiovascular Disease in HIV (MIRACLE HIV Study)

Condition:   HIV
Interventions:   Drug: Eplerenone;   Drug: Placebo;   Behavioral: Lifestyle Modification
Sponsor:   Massachusetts General Hospital
Recruiting - verified January 2017

A Single Arm Trial Evaluating the BARD Lutonix Drug-Coated Balloon (LTX DCB) for Treatment of Femoropopliteal Arteries

Conditions:   Femoral Artery Stenosis;   Femoral Artery Occlusion;   Stenosis of Popliteal Arteries;   Occlusion of Popliteal Arteries
Intervention:   Device: LTX DCB
Sponsor:   C. R. Bard
Recruiting - verified January 2017

BeSmooth Study, Investigating the BeSmooth Peripheral Stent System for the Treatment of Iliac Lesions

Condition:   Peripheral Arterial Disease
Intervention:   Device: BeSmooth peripheral stent
Sponsor:   Flanders Medical Research Program
Completed - verified February 2016

Influence of a Multi-parametric Optimization Strategy for General Anesthesia on Postoperative Morbidity and Mortality

Conditions:   Coronary; Ischemic;   Arrhythmias, Cardiac;   Heart Failure;   Peripheral Vascular Diseases;   Dementia;   Stroke;   Pulmonary Disease, Chronic Obstructive;   Respiratory Insufficiency;   Alcoholism;   Cancer;   Diabetes;   Renal Insufficiency
Interventions:   Procedure: OPTI-AGED;   Procedure: Usual Care
Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
Not yet recruiting - verified January 2017

A phase3 Study Measuring the Effect of Rosuvastatin 20 mg on Carotid Intima-Media Thickness in Chinese Subjects With Subclinical Atherosclerosis

Condition:   Atherosclerosis
Interventions:   Drug: Rosuvastatin;   Drug: Placebo
Sponsor:   AstraZeneca
Recruiting - verified January 2017

Dose-Ranging Study to Evaluate the Glycemic Effects, Safety, and Tolerability of Metformin Delayed Release in Subjects With T2DM

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Met DR;   Drug: Met IR;   Drug: Placebo
Sponsor:   Elcelyx Therapeutics, Inc.
Completed - verified January 2017

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Condition:   Peripheral Artery Disease
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Rivaroxaban-Placebo
Sponsors:   Bayer;   Janssen Research & Development, LLC;   Colorado Prevention Center
Recruiting - verified January 2017

Real-World Registry Assessing the Clinical Use of the Lutonix 035 Drug Coated Balloon Catheter

Conditions:   Peripheral Arterial Disease;   Peripheral Vascular Diseases;   Arterial Occlusive Diseases
Intervention:   Device: PTA (Lutonix® 035 DCB Catheter)
Sponsor:   C. R. Bard
Active, not recruiting - verified January 2017

Non-Interventional Post Marketing Surveillance Study of Neovasculgen® in Patients With Chronic Lower Limb Ischemia

Condition:   Lower Limb Ischemia
Intervention:   Drug: Neovasculgen®
Sponsor:   Human Stem Cell Institute, Russia
Completed - verified February 2015

Mediators of Atherosclerosis in South Asians Living in America (MASALA) Social Network Study

Condition:   Atherosclerosis
Intervention:  
Sponsors:   Northwestern University;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified January 2017

Physician-Initiated Trial Investigating the BeGraft Peripheral Stent Graft System

Condition:   Peripheral Vascular Disease
Intervention:   Device: BeGraft Peripheral Stent Graft System
Sponsor:   Flanders Medical Research Program
Completed - verified February 2016

Zilver® PTX® in China

Condition:   Peripheral Artery Disease
Intervention:   Device: Zilver® PTX® Drug-Eluting Peripheral Stent
Sponsor:   Cook
Active, not recruiting - verified January 2017

Multicenter, Prospective, Randomized, Controlled, Double-blind Trial on the Impact of Rosuvastatin on Subclinical Markers of Atherosclerosis in Patients With Primary Necrotizing Vasculitides

Condition:   ANCA-associated Primary Necrotizing Vasculitides
Interventions:   Drug: Rosuvastatin;   Drug: Placebo
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting - verified January 2017

Angioshield First-In-Human Study to Demonstrate the Preliminary Safety and Efficacy

Condition:   Coronary Artery Disease
Intervention:   Device: Angioshield
Sponsor:   Neograft Technologies, Incorporated
Completed - verified January 2017

Cook Micronized Small Intestinal Submucosa (SIS) for Critical Limb Ischemia

Conditions:   Ischemia;   Peripheral Arterial Disease;   Peripheral Vascular Diseases
Intervention:   Device: Micronized Small Intestinal Submucosa (SIS)
Sponsor:   Cook
Completed - verified January 2017

The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Terminated - verified January 2017

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Terminated - verified January 2017

The Cook Zilver PTX Drug-eluting Stent Versus Bypass Surgery for the Treatment The Cook Zilver PTX Drug-eluting Stent Versus Bypass Surgery of Femoropopliteal TASC C&D Lesions

Condition:   Peripheral Vascular Disease
Interventions:   Device: Zilver PTX;   Device: prosthetic bypass
Sponsor:   Flanders Medical Research Program
Recruiting - verified August 2016

The Psoriasis, Atherosclerosis, and Cardiometabolic Disease Initiative (PACI)

Conditions:   Metabolic Disease;   Cardiovascular Disease;   Inflammation
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified October 2016

Optical Frequency Domain Imaging (OFDI) and Vascular Healing After Stent Placement Diabetics Presenting With Acute Coronary Syndrome

Condition:   Coronary Artery Disease
Intervention:   Device: Resolute Integrity stent
Sponsor:   Emory University
Completed - verified January 2017

A Proposed Study of Atherosclerotic Plaques in Leg Arteries

Conditions:   Vascular Disease;   Diabetes
Intervention:  
Sponsor:   Southwest Regional Wound Care Center
Active, not recruiting - verified January 2017

Rosuvastatin Use to Improve the Coagulation Profile in Patients With Venous Thrombosis

Conditions:   Deep Vein Thrombosis;   Pulmonary Embolism
Intervention:   Drug: Rosuvastatin
Sponsors:   Leiden University Medical Center;   Netherlands Heart Foundation
Completed - verified January 2017

Motivational Interviewing (MI) for African Americans With Peripheral Arterial Disease (PAD)

Condition:   Peripheral Arterial Disease
Interventions:   Behavioral: Motivational Interviewing;   Behavioral: PACE
Sponsors:   University of Kansas Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified January 2017

Modulation of Monocyte Activation by Atorvastatin in HIV Infection

Condition:   HIV Dementia
Intervention:   Drug: Atorvastatin
Sponsors:   University of Pennsylvania;   National Institute of Allergy and Infectious Diseases (NIAID)
Active, not recruiting - verified January 2017

Cohort of Young Adults Infected With HIV Since Birth or During Childhood

Conditions:   HIV Infection;   Young Adult
Intervention:   Biological: blood sampling, specific biological exams and biobank and self administered questionnaires
Sponsor:   French National Agency for Research on AIDS and Viral Hepatitis
Active, not recruiting - verified January 2017

Drug-Eluting Stents vs. Bare Metal Stents In Saphenous Vein Graft Angioplasty

Condition:   Saphenous Vein Graft Atherosclerosis
Interventions:   Device: Bare Metal Stent;   Device: Drug-Eluting Stent;   Drug: Blinded clopidogrel;   Drug: Placebo;   Drug: Thienopyridine (open-label)
Sponsor:   VA Office of Research and Development
Completed - verified January 2017

Oral Paricalcitol in Stage 3 - 5 Chronic Kidney Disease

Condition:   Chronic Kidney Disease
Intervention:   Drug: paricalcitol
Sponsors:   The University of Hong Kong;   Abbott
Completed - verified January 2017

Peroxisome Proliferator-Activated Receptor-Gamma Activation in Peritoneal Dialysis Patients

Condition:   End-stage Renal Disease
Interventions:   Drug: Pioglitazone;   Drug: placebo comparator
Sponsors:   The University of Hong Kong;   Baxter Healthcare Corporation
Completed - verified January 2017

Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) Agonist in Diabetic End-Stage Renal Disease Patients

Conditions:   Endstage Renal Disease;   Diabetes
Interventions:   Drug: Pioglitazone;   Drug: Placebo comparator
Sponsor:   The University of Hong Kong
Completed - verified January 2017