Atherosclerosis

Clinical Trial Finder

Many patients with atherosclerosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Study to Gain Insights in Treatment Patterns and Outcomes in Patients With Atherosclerosis Prescribed to Xarelto in Combination With Acetylsalicylic Acid

Condition:   Atherosclerosis
Interventions:   Drug: Rivaroxaban (BAY59-7939, Xarelto);   Drug: Acetylsalicylic acid
Sponsors:   Bayer;   Janssen, LP
Recruiting

Effect of Smoking on Pain and Atherosclerosis in Patients With Rheumatoid Arthritis

Conditions:   Rheumatoid Arthritis;   Atherosclerosis;   Pain
Intervention:  
Sponsor:   Vastra Gotaland Region
Recruiting

Anti-inflammatory Status in DM2 Treated Patients

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Metformin / alogliptin Oral Product;   Drug: Metformin / Pioglitazone Pill;   Drug: triple therapy
Sponsor:   University of Catanzaro
Not yet recruiting

Causes and Natural History of Dyslipidemias

Conditions:   Hypercholesterolemia;   Atherosclerosis
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Stroke Prevention in the Wisconsin Native American Population

Conditions:   Stroke;   Atherosclerosis
Interventions:   Other: High Risk - intensive coaching;   Other: High Risk - standard care;   Other: Low Risk - control
Sponsors:   University of Wisconsin, Madison;   Wisconsin Partnership Program
Not yet recruiting

The Lipid-Rich Plaque Study

Conditions:   Coronary Artery Disease;   Atherosclerosis
Intervention:   Device: NIRS-IVUS Imaging (TVC Imaging System)
Sponsors:   InfraReDx;   Medstar Health Research Institute
Completed

Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

Conditions:   Prediabetic State;   Atherosclerosis;   Metformin
Interventions:   Drug: Metformin XR;   Drug: Placebo
Sponsor:   VA Office of Research and Development
Recruiting

Extracellular RNAs in Relation to Cardiometabolic Risk

Conditions:   Subclinical Atherosclerotic Cardiovascular Disease;   Blood Pressure;   Obesity
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation

Pragmatic Trial of Messaging to Providers About Treatment of Hyperlipidemia (PROMPT-LIPID)

Condition:   High Risk Atherosclerotic Cardiovascular Disease
Intervention:   Other: Electronic Alert
Sponsor:   Yale University
Not yet recruiting

Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia

Condition:   Eligible Men or Women Considered High Risk for Atherosclerotic Cardiovascular Disease (CVD)
Interventions:   Drug: Epanova® (omega-3 carboxylic acids);   Drug: corn oil control
Sponsors:   AstraZeneca;   The Cleveland Clinic;   IQVIA RDS Inc.
Active, not recruiting

The Genetic, Protein, and Lipid Basis of Variation in Cholesterol Efflux

Condition:   Lipid Metabolism Disorders
Intervention:  
Sponsors:   University of Texas Southwestern Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Suspended

Dietary Protein and Monocyte/Macrophage Mammalian Target of Rapamycin (mTOR) Signaling

Condition:   Dietary Protein
Intervention:   Dietary Supplement: Dietary protein shake
Sponsor:   Washington University School of Medicine
Suspended

HCQ for the CVD in CKD

Conditions:   Chronic Kidney Disease;   Cardiovascular Disease;   Inflammation;   Atherosclerosis;   Aortic Stiffness
Interventions:   Procedure: MRI carotid;   Procedure: APWV;   Drug: Hydroxychloroquine;   Drug: Matching Placebo
Sponsor:   VA Office of Research and Development
Recruiting

Optimizing Statin Tratment in People Living With Diabetes

Condition:   Diabetes
Intervention:  
Sponsor:   University Hospital, Montpellier
Completed

Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis

Conditions:   Psoriasis;   Atherosclerotic Cardiovascular Disease;   Obesity;   Dyslipidemia;   Cardiometabolic Diseases
Interventions:   Dietary Supplement: Niagen;   Other: Placebo
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Hemostatic Endothelial Dysfunction in Patients With Peripheral Artery Disease

Conditions:   Peripheral Artery Disease;   Restenosis of Peripheral Vascular Stent;   Restenosis, Vascular Graft;   Endothelial Dysfunction
Intervention:   Procedure: an arterial reconstructive procedure
Sponsor:   Ryazan State Medical University
Active, not recruiting

Study of the Effect of Innate on the Inflammatory Response to Endotoxin

Conditions:   Asthma;   Atherosclerosis;   Metabolic Syndrome;   Insulin Resistance;   Cancer
Intervention:  
Sponsor:   National Institute of Environmental Health Sciences (NIEHS)
Enrolling by invitation

Cardiovascular Disease Screening

Conditions:   Congenital Heart Disease;   Atherosclerosis;   Myocardial Ischemia;   Myocardial Infarction;   Acquired Heart Disease
Interventions:   Device: Toshiba Aquilion ONE CT;   Device: SWiemens MRI scanner
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Suspended

Association of Constipation Inflammatory and Microbial Translocation Markers

Conditions:   Constipation;   Inflammation
Intervention:  
Sponsor:   Tungs’ Taichung Metroharbour Hospital
Recruiting

Outcomes of Renal Access Arteriovenous Fistulas for Hemodialysis in Patients With Chronic Renal Failure

Condition:   End Stage Renal Disease
Intervention:   Procedure: observational study
Sponsor:   Institute of Liver and Biliary Sciences, India
Completed

Sitagliptin Therapy and Kinetics of Inflammatory Markers

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Sitagliptin;   Drug: Placebo
Sponsors:   Laval University;   Merck Sharp & Dohme Corp.
Completed

Insulin Resistance, Sarcopenia and Plasma BAIBA Levels

Conditions:   Sarcopenia;   Insulin Resistance
Intervention:  
Sponsor:   Tungs’ Taichung Metroharbour Hospital
Recruiting

Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial

Condition:   Rheumatoid Arthritis
Intervention:   Drug: Doxycycline Tablets
Sponsor:   Assiut University
Completed

Study of Clinical Features and Genetics of Hyperimmunoglobulin E Recurrent Infection

Conditions:   Coronary Aneurysm;   Dermatitis, Atopic;   Immune System Diseases;   STAT3 Transcription Factor;   Job Syndrome
Intervention:  
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Albert Einstein College of Medicine
Recruiting

Environmental and Biological Monitoring Pilot Study for Polycyclic Aromatic Hydrocarbons in Linxian, China

Condition:   Esophageal Cancer
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Completed

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

Conditions:   Cardiomyopathy;   Li-Fraumeni Syndrome;   Parkinson's Disease;   Atherosclerosis;   Cardiovascular Capacity
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Efficacy and Safety of Angelica Gigas Nakai and Allium Cepa L.Extract Mixtures on the Improvement of Blood Flow

Condition:   Blood Flow
Interventions:   Dietary Supplement: Angelica Gigas Nakai and Allium Cepa L.Extract Mixtures;   Dietary Supplement: Placebo
Sponsor:   Chonbuk National University Hospital
Recruiting

Study of the Disease Process of Lymphangioleiomyomatosis

Conditions:   Lung Disease;   Pneumothorax;   Tuberous Sclerosis;   Lymphangioleiomyomatosis
Intervention:   Device: Toshibia Aquilion One CT
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Apnea, Stroke and Incident Cardiovascular Events

Conditions:   Stroke;   Sleep-disordered Breathing;   Sleep Apnea Syndromes;   Sleep Apnea, Obstructive;   Sleep Apnea, Central;   Fragmentation, Sleep
Intervention:   Device: Treatment according to standard care recommandation
Sponsor:   University Hospital, Grenoble
Not yet recruiting

Comparison of Cardiac Computed Tomography and Vasodilator Stress Magnetic Resonance Imaging Perfusion in Patients With Prior Equivocal Stress Test for Detection of Coronary Artery Disease

Condition:   Coronary Artery Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Suspended

Safety and Effectiveness of the Orsiro Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions

Conditions:   Coronary Artery Disease;   Atherosclerosis, Coronary;   Myocardial Ischemia;   Ischemic Heart Disease;   Acute Coronary Syndrome;   Angina Pectoris
Intervention:   Device: Orsiro DES
Sponsor:   Biotronik, Inc.
Recruiting

Telephone Health Coaching and Remote Exercise Monitoring for Peripheral Artery Disease

Conditions:   Peripheral Artery Disease;   Atherosclerosis;   Peripheral Arterial Disease;   Arterial Occlusive Diseases;   Vascular Diseases;   Peripheral Vascular Diseases;   Cardiovascular Diseases
Intervention:   Behavioral: TeGeCoach
Sponsor:   Universitätsklinikum Hamburg-Eppendorf
Active, not recruiting

Pivotal Study of the Medtronic Axys EX Rotational Atherectomy System

Condition:   Peripheral Arterial Disease
Intervention:   Device: Axys EX device
Sponsor:   Medtronic Endovascular
Not yet recruiting

HIV-HEART Aging Study (15 Year Follow up)

Conditions:   HIV Infections;   Coronary Disease;   Myocardial Infarction;   HIV Encephalopathy;   Aging;   Heart Failure;   Weight Gain
Intervention:  
Sponsor:   University Hospital, Essen
Recruiting

Real-World Registry Assessing the Clinical Use of the Lutonix 035 Drug Coated Balloon Catheter

Conditions:   Peripheral Arterial Disease;   Peripheral Vascular Diseases;   Arterial Occlusive Diseases
Intervention:   Device: PTA (Lutonix® 035 DCB Catheter)
Sponsor:   C. R. Bard
Completed

Pathophysiological Study of Adipose Tissue of Patients Infected With HIV

Condition:   HIV
Intervention:  
Sponsor:   Centre de Recherches et d'Etude sur la Pathologie Tropicale et le Sida
Recruiting

A Prospective, Multicenter Atherectomy Study Showing Luminal Gain in Subjects With Peripheral Vascular Blockages

Condition:   Peripheral Arterial Disease
Intervention:   Device: Atherectomy
Sponsor:   Ra Medical Systems
Recruiting

Major Adverse Limb Events in Patients With Femoro-popliteal and Below-the-knee Peripheral Arterial Disease Treated With Either Sirolimus-coated Balloon or Standard Uncoated Balloon Angioplasty

Condition:   Peripheral Arterial Disease
Interventions:   Device: sirolimus-coated balloon catheter;   Device: uncoated balloon catheter
Sponsor:   Nils Kucher
Not yet recruiting

Post-Market Registry of AURYON™ Atherectomy Device in Subjects Affected With Infrainguinal Peripheral Artery Disease

Conditions:   Infrainguinal Peripheral Artery Disease;   Peripheral Arterial Disease;   PAD
Intervention:   Device: AURYON™ System
Sponsor:   Angiodynamics, Inc.
Not yet recruiting

Effects of Esmolol Infusion on Hemodynamic Responses to Isometric Handgrip

Conditions:   Peripheral Arterial Disease;   Aging
Interventions:   Drug: Esmolol infusion;   Drug: Saline infusion;   Other: Pre exercise baseline;   Other: Isometric handgrip exercise;   Other: Post exercise cuff occlusion;   Other: Recovery
Sponsor:   David N. Proctor, PhD
Not yet recruiting

FRAME, External Support for Lower Limb Autologous Grafts

Conditions:   Peripheral Arterial Disease;   Peripheral Artery Disease
Intervention:   Device: FRAME
Sponsor:   Vascular Graft Solutions Ltd.
Recruiting

TRanslesIonal Assessment of Gradients During Endovascular Therapy

Conditions:   Peripheral Arterial Disease;   Fractional Flow Reserve;   Hemodynamics
Intervention:   Device: Translesional Hemodynamic Measurement
Sponsor:   The University of Texas Health Science Center at San Antonio
Active, not recruiting

Physical Activity Daily - An Internet-Based Walking Program for Patients With Peripheral Arterial Disease

Condition:   Peripheral Arterial Disease
Interventions:   Behavioral: Telephone counseling;   Behavioral: Internet-based walking program
Sponsor:   University of Alabama at Birmingham
Recruiting

Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes

Condition:   Peripheral Arterial Disease
Intervention:  
Sponsors:   University of Texas Southwestern Medical Center;   Boston Scientific Corporation
Recruiting

Preoperative Continuous Sciatic Perineural Analgesia in Patients Undergoing Lower Limb Revascularization

Conditions:   Ischemic Leg;   Peripheral Vascular Disease
Intervention:  
Sponsor:   Hospital Municipal Miguel Couto
Completed

Prospective Case-control Study in Patients With PAA

Conditions:   Popliteal Artery Aneurysm;   Peripheral Arterial Disease;   Quality of Life
Intervention:   Other: Bypass surgery
Sponsors:   Iva Jergovic;   Karolinska University Hospital;   Karolinska Institutet;   Stockholm South General Hospital;   Sahlgrenska University Hospital, Sweden
Recruiting

Low-Carbohydrate Dietary Pattern on Glycemic Outcomes Trial

Conditions:   Diabetes;   PreDiabetes;   Metabolic Disease;   Hyperglycemia;   Diet Modification;   Glucose Intolerance;   Glucose Metabolism Disorders (Including Diabetes Mellitus);   Endocrine System Diseases
Intervention:   Behavioral: Low-Carbohydrate Diet
Sponsors:   Tulane University School of Public Health and Tropical Medicine;   National Institute of General Medical Sciences (NIGMS)
Recruiting

Implementation of Vascular Care Team to Improve Medical Management of PAD Patients

Condition:   Peripheral Artery Disease
Interventions:   Other: Intervention A - Vascular Care Team Approach;   Other: Intervention B - Standard Care
Sponsor:   Colorado Prevention Center
Not yet recruiting

Acotec DCB Post Market Clinical Follow-up

Condition:   Peripheral Artery Disease
Intervention:   Device: AcoArt Orchid (0.035"), AcoArt Tulip (0.018") and AcoArt Litos (0.014") percutaneous transluminal angioplasty (PTA) paclitaxel drug coated balloon catheter manufactured by Acotec Scientific Co., Ltd.
Sponsor:   Acotec Scientific Co., Ltd
Not yet recruiting

Influence of Rivaroxaban for Intermittent Claudication and Exercise Tolerance in Patients With Symptomatic PAD

Condition:   Peripheral Arterial Disease
Interventions:   Drug: Rivaroxaban;   Drug: ASA
Sponsors:   Poznan University of Medical Sciences;   Poznan University of Physical Education;   Institute of Human Genetics, Polish Academy of Sciences
Not yet recruiting

REvascularization RateS and Clinical OUtcomes With DABRA Laser. A Long-Term 2-year Study

Condition:   Peripheral Artery Disease
Intervention:   Device: Endovascular Treatment of PAD
Sponsor:   Ra Medical Systems
Active, not recruiting

Investigation of Factors Affecting Cardiorespiratory Fitness in Individuals With Systemic Hypertension

Conditions:   Systemic Hypertension;   Muscle Weakness;   Vascular Stiffness
Intervention:  
Sponsor:   Hacettepe University
Not yet recruiting

Use of Ixmyelocel-T (Formerly Vascular Repair Cells [VRC]) in Patients With Peripheral Arterial Disease to Treat Critical Limb Ischemia

Condition:   Peripheral Arterial Disease
Interventions:   Biological: Ixmyelocel-T;   Biological: Placebo
Sponsor:   Vericel Corporation
Completed

Study of AMG0001 to Improve Ulcer Healing and Perfusion in Subjects With Peripheral Ischemic Ulcers

Conditions:   Peripheral Artery Disease;   Ischaemic Ulcer of Lower Leg Due to Atherosclerotic Disease;   Chronic Limb Threatening Ischemia;   Ischemic Ulcer of Foot
Interventions:   Biological: AMG0001;   Biological: Placebo
Sponsor:   AnGes USA, Inc.
Recruiting

Assessment of Carotid Artery Stenosis and Lower Limb Peripheral Ischemia Prior to CABG

Conditions:   Carotid Artery Diseases;   Peripheral Artery Disease
Intervention:   Diagnostic Test: carotid duplex, both LL arterial duplex
Sponsor:   Mr Ihab Ali
Completed

BARD® The VENOVO™ Venous Stent Study for Treatment of Iliofemoral Occlusive Disease

Conditions:   May-Thurner Syndrome;   Peripheral Vascular Disease;   Venous Disease;   Iliofemoral Occlusive Disease
Intervention:   Device: VENOVO™ Venous Stent
Sponsor:   C. R. Bard
Active, not recruiting

Stimulation TcPO2 Test in the PAD Diagnosis in Diabetic Foot

Condition:   Peripheral Arterial Disease
Intervention:   Diagnostic Test: Stimulation TcPO2 test
Sponsors:   Institute for Clinical and Experimental Medicine;   General University Hospital in Prague;   Motol University Hospital
Completed

Study to Learn More About the Effectiveness and Safety of Rivaroxaban (Xarelto) When Given Together With Acetylsalicylic Acid to Patients Suffering From a Condition That Affects the Blood Vessels Supplying the Heart (CAD) and/or a Condition That Affects the Blood Vessel of the Lower Limbs (PAD).

Conditions:   Coronary Artery Disease(CAD);   Peripheral Artery Disease(PAD)
Interventions:   Drug: Rivaroxaban (Xarelto,Bay 59-7939);   Drug: Acetylsalicylic acid(ASA)
Sponsor:   Bayer
Not yet recruiting