Aortic Valve Stenosis

Clinical Trial Finder

Many patients with aortic valve stenosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Cingularbio® Heart Valve Clincial Study

Condition:   Aortic Valve Stenosis
Intervention:   Device: Cingularbio® Aortic valve replacement
Sponsor:   Shanghai Cingularbio Co. Ltd
Recruiting - verified April 2016

Medtronic CoreValve Evolut R U.S. Clinical Study (Evolut 34R Addendum)

Condition:   Aortic Valve Stenosis
Intervention:   Device: CoreValve Evolut 34R TAVR system
Sponsor:   Medtronic Cardiovascular
Not yet recruiting - verified April 2016

Williams Syndrome (WS) and Supravalvular Aortic Stenosis (SVAS) DNA and Tissue Bank

Conditions:   Williams Syndrome;   Supravalvular Aortic Stenosis;   Cardiovascular Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified February 2016

Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction

Conditions:   Complex Congenital Heart Defect;   Dysfunctional RVOT Conduits
Intervention:   Device: SAPIEN 3 THV
Sponsor:   Edwards Lifesciences
Not yet recruiting - verified April 2016

WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study)

Conditions:   Williams Syndrome;   Cardiovascular Disease;   Multisystem Developmental Disorder;   Elastin Gene Deletion;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified February 2016

The PARTNER II Trial: S3iCAP

Condition:   Aortic Stenosis
Intervention:   Device: TAVR with SAPIEN S3 valve
Sponsor:   Edwards Lifesciences
Recruiting - verified February 2016

CoreValve™ Evolut R™ FORWARD Study

Condition:   Aortic Valve Stenosis
Intervention:   Device: Medtronic CoreValve™ Evolut R™ System
Sponsor:   Medtronic Cardiovascular
Recruiting - verified April 2016

Feasibility And Safety of Early Discharge After Transfemoral Transcatheter Aortic Valve Implantation

Condition:   Aortic Stenosis
Intervention:   Device: TF TAVI
Sponsors:   Institut für Pharmakologie und Präventive Medizin;   Edwards Lifesciences
Recruiting - verified December 2015

CoreValve VIVA Study Evaluation of the Clinical Outcomes of CoreValve in Degenerative Surgical Aortic Bioprosthesis.

Condition:   Aortic Valve Stenosis
Intervention:   Device: CoreValve Transcatheter Valve
Sponsor:   Medtronic Bakken Research Center
Recruiting - verified April 2016

Balloon Expandable Transcatheter Aortic Valve Implantation Without Predilation of the Aortic Valve

Condition:   Aortic Valve Stenosis
Interventions:   Procedure: BAV;   Procedure: no BAV
Sponsor:   Institut für Pharmakologie und Präventive Medizin
Recruiting - verified January 2016

Engager Align Post-market Clinical Study

Condition:   Aortic Valve Stenosis
Intervention:   Device: Engager Transcatheter Aortic Valve Implantation System
Sponsor:   Medtronic Bakken Research Center
Active, not recruiting - verified April 2016

ROUTE Registry Of the Utilisation of the Transaortic (Tao) TAVI Approach Using the Edwards Sapien XT Valve

Condition:   Aortic Stenosis
Intervention:  
Sponsor:   Institut für Pharmakologie und Präventive Medizin
Active, not recruiting - verified April 2016

Alternative Access Approaches for Transcatheter Aortic Valve Replace (TAVR) in Inoperable Patients With Aortic Stenosis

Condition:   Severe Symptomatic Aortic Stenosis
Intervention:   Device: Edwards SAPIEN Transcatheter Heart Valve
Sponsors:   The Society of Thoracic Surgeons;   American College of Cardiology
Completed - verified April 2016

Engager Direct Aortic Clinical Study

Condition:   Aortic Valve Stenosis
Intervention:   Device: Engager™ aortic valve
Sponsor:   Medtronic Bakken Research Center
Completed - verified April 2016

STS/ACC Transcatheter Valve Therapy Registry (TVT Registry)

Condition:   Aortic Valve Stenosis
Intervention:   Procedure: Transcatheter Aortic Valve Replacement
Sponsors:   The Society of Thoracic Surgeons;   American College of Cardiology
Recruiting - verified April 2016

Enable® Aortic Sutureless Bioprosthesis Evaluation

Conditions:   Aortic Valve Stenosis;   Aortic Valve Insufficiency
Intervention:   Procedure: Aortic Valve Replacement surgery
Sponsor:   Medtronic Bakken Research Center
Active, not recruiting - verified April 2016

Safety & Efficacy Study of the Medtronic CoreValve® System-Treatment of Symptomatic Severe Aortic Stenosis With Significant Comorbidities in Very High Risk Subjects Who Need Aortic Valve Replacement

Condition:   Severe Aortic Stenosis
Intervention:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting - verified April 2016

Enable I Long-term Follow-up Study

Conditions:   Aortic Valve Stenosis;   Aortic Valve Insufficiency
Intervention:   Device: Aortic Valve Replacement
Sponsor:   Medtronic Bakken Research Center
Active, not recruiting - verified April 2016

Triple Chamber Pacing in Hypertrophic Obstructive Cardiomyopathy (HOCM) Patients - TRICHAMPION STUDY

Condition:   Hypertrophic Cardiomyopathy With Obstruction
Intervention:   Device: CRT-P Implant
Sponsor:   St. Jude Medical
Recruiting - verified April 2016

Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI).

Condition:   Severe Aortic Stenosis
Interventions:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI);   Procedure: Surgical Aortic Valve Replacement (SAVR);   Device: Medtronic CoreValve® Evolut R System Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Medtronic Cardiovascular
Recruiting - verified April 2016

Post-Approval Study for the MOSAIC® Bioprostheses

Conditions:   Aortic Valve Stenosis and/or Insufficiency;   Mitral Valve Stenosis and/or Insufficiency
Intervention:  
Sponsor:   Medtronic Bakken Research Center
Active, not recruiting - verified April 2016

Safety and Efficacy Continued Access Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in Very High Risk Subjects and High Risk Subjects Who Need Aortic Valve Replacement

Condition:   Severe Aortic Stenosis
Intervention:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting - verified April 2016

Transapical Implantation of the Medtronic Engager Transcatheter Aortic Valve Implantation System - The Engager European Pivotal Trial

Condition:   Aortic Valve Stenosis
Intervention:   Device: Medtronic Engager Transcatheter Aortic Valve Implantation System
Sponsor:   Medtronic Bakken Research Center
Active, not recruiting - verified April 2016

CoreValve Advance International Post Market Study

Condition:   Severe Aortic Stenosis
Intervention:   Device: Medtronic CoreValve System
Sponsor:   Medtronic Bakken Research Center
Active, not recruiting - verified April 2016

The Nordic Aortic Valve Intervention Trial

Condition:   Critical Aortic Stenosis
Interventions:   Procedure: Transcatheter Aortic Valve Implantation;   Procedure: Surgical Aortic Valve Replacement
Sponsors:   Rigshospitalet, Denmark;   Odense University Hospital;   Sahlgrenska University Hospital, Sweden;   Danish Heart Foundation;   Copenhagen Trial Unit, Center for Clinical Intervention Research
Active, not recruiting - verified April 2016