Aortic Valve Stenosis

Clinical Trial Finder

Many patients with aortic valve stenosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Assessments of Thrombus Formation in TAVI

Conditions:   Aortic Valve Stenosis;   Heart Valve Diseases
Sponsor:   Kumamoto University
Recruiting - verified August 2017

Image Fusion and Calcification Raising in Trans Aortic Valve Implantation

Condition:   Symptomatic Aortic Stenosis
Intervention:   Other: Image Fusion
Sponsor:   Nantes University Hospital
Not yet recruiting - verified July 2017

Insertable Cardiac Monitors in Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Intervention:   Device: Insertable cardiac monitor
Sponsors:   Region Gävleborg;   St. Jude Medical;   Norrlands University Hospital
Recruiting - verified August 2017

Small Aortic Annulus - a New Solution to the Old Problem

Condition:   Aortic Valve Replacement
Intervention:   Procedure: aortic valve replacement
Sponsor:   The Federal Centre of Cardiovascular Surgery, Russia
Active, not recruiting - verified August 2017

Nitrite in Hypertrophic Cardiomyopathy (HCM) Study

Condition:   Cardiomyopathy, Hypertrophic
Interventions:   Drug: Sodium Nitrate;   Drug: Placebo;   Diagnostic Test: Phosphorous Magnetic Resonance Spectroscopy;   Diagnostic Test: Exercise Stress Transthoracic Echocardiogram
Sponsors:   University of East Anglia;   Norfolk and Norwich University Hospitals NHS Foundation Trust;   British Medical Research Council
Recruiting - verified August 2017

Microvascular Dysfunction in Nonischemic Cardiomyopathy: Insights From CMR Assessment of Coronary Flow Reserve

Conditions:   Hypertrophic Cardiomyopathy;   Non-ischemic Dilated Cardiomyopathy;   Microvascular Ischaemia of Myocardium
Interventions:   Drug: Regadenoson;   Drug: Adenosine
Sponsor:   Duke University
Not yet recruiting - verified August 2017

WATCH-TAVR, WATCHMAN for Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement

Conditions:   Atrial Fibrillation;   Aortic Valve Stenosis
Interventions:   Device: WATCHMAN;   Device: TAVR
Sponsors:   Samir Kapadia;   Boston Scientific Corporation;   The Cleveland Clinic
Not yet recruiting - verified August 2017

Early Detection of Aortic Stenosis in the Community During Flu Vaccination

Condition:   Aortic Stenosis
Sponsors:   Institut für Pharmakologie und Präventive Medizin;   Edwards Lifesciences
Not yet recruiting - verified August 2017

Evaluation of Transcatheter Aortic Valve Replacement Compared to SurveilLance for Patients With AsYmptomatic Severe Aortic Stenosis

Conditions:   Aortic Stenosis;   Heart Diseases
Intervention:   Device: Edwards SAPIEN 3 THV
Sponsor:   Edwards Lifesciences
Recruiting - verified August 2017

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

Condition:   Mitral Valve Failure
Interventions:   Device: Edwards SAPIEN 3 transcatheter heart valve;   Device: ASHI INTECC Astato XS 20
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation - verified August 18, 2017

Evaluation of Length of Stay After TF-TAVI

Condition:   Severe Symptomatic Aortic Stenosis
Intervention:   Procedure: Transfemoral Transcatheter aortic valve implantation
Sponsor:   University Hospital, Rouen
Recruiting - verified August 2017

Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT)

Conditions:   Aortic Valve Stenosis;   Cardiovascular Diseases;   Heart Valve Diseases;   Ventricular Outflow Obstruction;   Thrombosis
Interventions:   Drug: Acetylicsalicylic acid;   Drug: Clopidogrel;   Drug: Rivaroxaban
Sponsors:   ECRI bv;   Rigshospitalet, Denmark;   Bayer;   Cardialysis BV
Recruiting - verified August 2017

Home-Based Exercise Program For Recovery After Transcatheter Aortic Valve Replacement

Condition:   Aortic Valve Stenosis
Interventions:   Behavioral: Exercise;   Behavioral: Cognitive behavioral interventions;   Behavioral: Attention control education program
Sponsors:   Brigham and Women's Hospital;   Hebrew SeniorLife;   National Institute on Aging (NIA);   Beth Israel Deaconess Medical Center
Recruiting - verified August 2017

Transfemoral Transcatheter Aortic Valve Implantation With or Without Predilation of the Aortic Valve (EASE-IT TF)

Condition:   Aortic Stenosis
Interventions:   Other: with BAV;   Other: without BAV
Sponsor:   Institut für Pharmakologie und Präventive Medizin
Recruiting - verified August 2017


Condition:   Aortic Stenosis
Intervention:   Device: TAVR with SAPIEN S3 valve
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified August 2017

The PARTNER 3 - Trial - The Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis

Condition:   Aortic Stenosis
Interventions:   Procedure: Surgical aortic valve replacement (SAVR);   Device: Transcatheter Aortic Valve Replacement (TAVR)
Sponsor:   Edwards Lifesciences
Recruiting - verified July 2017

Safety and Performance Study of the Edwards CENTERA-EU Self-Expanding Transcatheter Heart Valve

Condition:   Aortic Valve Disease
Intervention:   Device: Edwards CENTERA Self-Expanding Transcatheter Heart Valve
Sponsors:   Edwards Lifesciences;   Medstar Health Research Institute;   European Cardiovascular Research Center;   University of British Columbia
Active, not recruiting - verified February 2017

Pediatric Cardiomyopathy Mutation Analysis

Conditions:   Cardiomyopathies;   Dilated Cardiomyopathy;   Hypertrophic Cardiomyopathy;   Restrictive Cardiomyopathy;   Arrhythmogenic Right Ventricular Cardiomyopathy;   Left Ventricular Non-compaction Cardiomyopathy
Sponsors:   Indiana University;   American Heart Association
Recruiting - verified August 2017

Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias

Conditions:   Inherited Cardiac Arrythmias;   Long QT Syndrome (LQTS);   Brugada Syndrome (BrS);   Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT);   Early Repolarization Syndrome (ERS);   Arrhythmogenic Cardiomyopathy (AC, ARVD/C);   Hypertrophic Cardiomyopathy (HCM);   Dilated Cardiomyopathy (DCM);   Muscular Dystrophies (Duchenne, Becker, Myotonic Dystrophy);   Normal Control Subjects
Sponsor:   Johns Hopkins University
Enrolling by invitation - verified August 2017

The Multidisciplinary, Multimodality, But Minimalist Approach to Transfemoral Transcatheter Aortic Valve Replacement

Condition:   Aortic Valve Stenosis
Intervention:   Other: Vancouver 3M Clinical Pathway
Sponsors:   BC Centre for Improved Cardiovascular Health;   University of British Columbia
Active, not recruiting - verified August 2017

Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement.

Conditions:   Heart Disease;   Aging;   Amyloidosis;   Aortic Valve Stenosis
Intervention:   Other: a basal LV septum biopsy
Sponsors:   French Cardiology Society;   Pfizer;   Henri Mondor University Hospital
Recruiting - verified August 2017

PERIGON Pivotal Trial

Condition:   Aortic Stenosis
Intervention:   Device: Model 400 aortic valve bioprosthesis
Sponsors:   Medtronic Cardiovascular;   Medtronic
Active, not recruiting - verified August 2017

The SOLACE-AU Clinical Trial

Condition:   Severe, Symptomatic Aortic Stenosis
Intervention:   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis
Sponsors:   Edwards Lifesciences;   Pacific Clinical Research Group
Active, not recruiting - verified August 2017

Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI).

Condition:   Severe Aortic Stenosis
Interventions:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI);   Procedure: Surgical Aortic Valve Replacement (SAVR) (Not applicable for Single Arm);   Device: Medtronic CoreValve® Evolut R System Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting - verified April 2017

PREVAIL-20J - Transfemoral Placement of 20mm Aortic Balloon Expandable Transcatheter Valve Trial

Condition:   Aortic Valve Stenosis
Intervention:   Device: SAPIEN XT NovaFlex delivery system
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified August 2017

Defining the Brain Phenotype of Children With Williams Syndrome

Condition:   Williams Syndrome
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting - verified August 9, 2017