Aortic Valve Stenosis

Clinical Trial Finder

Many patients with aortic valve stenosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Better Patient Selection to Transcatheter Aortic Valve Implantation

Conditions:   Aortic Valve Stenosis;   Left Ventricular Dysfunction;   Myocardial Fibrosis
Intervention:   Diagnostic Test: Dobutamine stress test
Sponsor:   Oslo University Hospital
Not yet recruiting - verified April 2017

Prehabilitation for Patients Undergoing Transcatheter Aortic Valve Replacement

Condition:   Aortic Valve Stenosis
Intervention:   Other: Pre-habilitation
Sponsors:   WellSpan Health;   Lancaster General Hospital
Recruiting - verified March 2017

Genomic Sequencing in Patients With HCM Undergoing Septal Myectomy

Conditions:   Hypertrophic Cardiomyopathy;   Genetic Disease;   Gene Product Sequence Variation
Intervention:   Genetic: Genomic sequencing
Sponsor:   The Cleveland Clinic
Not yet recruiting - verified April 2017

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

Condition:   Mitral Valve Failure
Interventions:   Device: Edwards SAPIEN 3 transcatheter heart valve;   Device: ASHI INTECC Astato XS 20
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified January 3, 2017

REpositionable Percutaneous Replacement of NatIve StEnotic Aortic Valve Through Implantation of LOTUS EDGE Valve System

Condition:   Aortic Valve Stenosis
Intervention:   Device: LOTUS Edge Valve System
Sponsor:   Boston Scientific Corporation
Active, not recruiting - verified April 2017

Impact of Elastin Mediated Vascular Stiffness on End Organs

Conditions:   Williams Syndrome;   Supravalvular Aortic Stenosis;   Cardiovascular Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 5, 2017

Clinical Value of Stress Echocardiography in Moderate Aortic Stenosis

Condition:   Aortic Valve Stenosis
Intervention:  
Sponsor:   London North West Healthcare NHS Trust
Recruiting - verified March 2017

A STEP for Patients Prior to Undergoing TAVR: A Pilot Study

Conditions:   Frail Elderly;   Aortic Valve Stenosis
Intervention:   Behavioral: Supervised TAVR Exercise Program
Sponsors:   OSF Healthcare System;   OSF St. Francis Medical Center;   HeartCare Midwest;   University of Illinois College of Medicine at Peoria
Recruiting - verified April 2017

The Medtronic TAVR 2.0 US Clinical Study

Condition:   Aortic Valve Stenosis
Intervention:   Device: Medtronic Transcatheter Aortic Valve 2.0 Replacement System
Sponsor:   Medtronic Cardiovascular
Active, not recruiting - verified April 2017

SecOnd-generation seLf-expandable Versus Balloon-expandable Valves and gEneral Versus Local Anesthesia in TAVI

Condition:   Aortic Stenosis
Interventions:   Device: CoreValve Evolut R;   Device: Edwards Sapien 3;   Procedure: Local anesthesia with conscious sedation;   Procedure: General anesthesia
Sponsors:   University of Luebeck;   University of Giessen and Marburg, Campus Giessen;   Heart Center Leipzig, University of Leipzig;   University Hospital Schleswig-Holstein, Campus Kiel;   Universitätsklinikum Hamburg-Eppendorf;   Klinikum der Stadt Ludwigshafen am Rhein;   Klinikum Links der Weser Bremen;   University of Schleswig-Holstein, Campus Lübeck
Recruiting - verified April 2017

Williams Syndrome (WS) and Supravalvular Aortic Stenosis (SVAS) DNA and Tissue Bank

Conditions:   Williams Syndrome;   Supravalvular Aortic Stenosis;   Cardiovascular Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 17, 2017

COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction

Conditions:   Complex Congenital Heart Defect;   Dysfunctional RVOT Conduits
Intervention:   Device: SAPIEN 3 THV
Sponsor:   Edwards Lifesciences
Recruiting - verified April 2017

WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study)

Conditions:   Williams Syndrome;   Cardiovascular Disease;   Multisystem Developmental Disorder;   Elastin Gene Deletion;   Hypertension
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 4, 2017

The PARTNER 3 - Trial - The Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis

Condition:   Aortic Stenosis
Interventions:   Procedure: Surgical aortic valve replacement (SAVR);   Device: Transcatheter Aortic Valve Replacement (TAVR)
Sponsor:   Edwards Lifesciences
Recruiting - verified April 2017

Sorin Universal REgistry on Aortic Valve Replacement

Conditions:   Aortic Valve Disease;   Aortic Stenosis
Intervention:  
Sponsor:   LivaNova
Recruiting - verified April 2017

Perceval Sutureless Implant Versus Standard-Aortic Valve Replacement

Conditions:   Aortic Valve Disease;   Aortic Stenosis
Interventions:   Device: Perceval valve;   Device: other stented biological valve
Sponsor:   LivaNova
Recruiting - verified April 2017

CoreValve™ Evolut R™ FORWARD Study

Condition:   Aortic Valve Stenosis
Intervention:   Device: Medtronic CoreValve™ Evolut R™ System
Sponsor:   Medtronic Cardiovascular
Active, not recruiting - verified April 2017

Assessment of Arrhythmias in Patients Undergoing Transcatheter Aortic Valve Implantation Using a Small Insertable Cardiac Monitoring Device

Condition:   Aortic Valve Stenosis
Intervention:  
Sponsor:   University Hospital Inselspital, Berne
Recruiting - verified April 2017

Incidence and Risk Factors for Hospitalization-Associated Disability

Conditions:   Functional Decline;   Hospitalization-associated Disability;   Iatrogenic Disease
Intervention:   Procedure: Not applicable (observational design)
Sponsors:   Universitaire Ziekenhuizen Leuven;   Katholieke Universiteit Leuven
Completed - verified March 2017

Neuroprotection in Patients Undergoing Aortic Valve Replacement

Conditions:   Aortic Stenosis;   Brain Infarction;   Cerebrovascular Accident;   Stroke
Interventions:   Device: Embol-X Embolic Protection Device;   Device: CardioGard Cannula
Sponsors:   Icahn School of Medicine at Mount Sinai;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified April 2017

Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic Access

Condition:   Aortic Valve Stenosis
Intervention:   Procedure: CA-TAVR
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation - verified March 6, 2017

CoreValve VIVA Study Evaluation of the Clinical Outcomes of CoreValve in Degenerative Surgical Aortic Bioprosthesis.

Condition:   Aortic Valve Stenosis
Intervention:   Device: CoreValve Transcatheter Valve
Sponsor:   Medtronic Bakken Research Center
Active, not recruiting - verified April 2017

The CardioPAT Project: A Randomized Trial

Conditions:   Coronary Artery Disease;   Aortic Stenosis;   Aortic Insufficiency;   Mitral Insufficiency;   Aortic Aneurysm
Intervention:   Device: cardioPAT cell saver
Sponsor:   Rigshospitalet, Denmark
Terminated - verified August 2016

Characterization and Role of Mutations in Sodium-phosphate Cotransporters in Patients With Calcific Aortic Valve Disease

Condition:   Aortic Valve Stenosis
Intervention:  
Sponsor:   Region Örebro County
Recruiting - verified April 2017

Use of Cardiac-MRI to Predict Results for People With Severe Aortic Stenosis

Condition:   Aortic Valve Stenosis
Intervention:  
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   Medstar Washington Hospital Center
Withdrawn - verified April 8, 2014

HCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Intervention:   Other: None - this is an observational study
Sponsors:   University of Virginia;   National Heart, Lung, and Blood Institute (NHLBI);   Oxford University Hospitals NHS Trust
Active, not recruiting - verified April 2017

Enable® Aortic Sutureless Bioprosthesis Evaluation

Conditions:   Aortic Valve Stenosis;   Aortic Valve Insufficiency
Intervention:   Procedure: Aortic Valve Replacement surgery
Sponsor:   Medtronic Bakken Research Center
Active, not recruiting - verified April 2017

REPRISE II: REpositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus™ Valve System

Condition:   Transcatheter Aortic Valve Replacement
Intervention:   Device: Lotus Valve System
Sponsor:   Boston Scientific Corporation
Active, not recruiting - verified April 2017

Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI).

Condition:   Severe Aortic Stenosis
Interventions:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI);   Procedure: Surgical Aortic Valve Replacement (SAVR) (Not applicable for Single Arm);   Device: Medtronic CoreValve® Evolut R System Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Medtronic Cardiovascular
Recruiting - verified April 2017

Post-Approval Study for the MOSAIC® Bioprostheses

Conditions:   Aortic Valve Stenosis and/or Insufficiency;   Mitral Valve Stenosis and/or Insufficiency
Intervention:  
Sponsor:   Medtronic Bakken Research Center
Active, not recruiting - verified April 2017

German TAVI-Register

Conditions:   Aortic Valve Stenosis;   Aortic Valve Insufficiency
Intervention:  
Sponsor:   Stiftung Institut fuer Herzinfarktforschung
Completed - verified June 2016

SOURCE XT REGISTRY

Condition:   Severe Aortic Stenosis
Interventions:   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified April 2017

Study to Develop a Non-invasive Marker for Monitoring Myocardial Fibrosis

Conditions:   Hypertrophic Cardiomyopathy;   Acute Coronary Syndrome
Intervention:   Radiation: 99mTc-NC100692
Sponsor:   Ottawa Heart Institute Research Corporation
Active, not recruiting - verified April 2017

The Perceived Impact of Children s Risk Status for Hypertrophic Cardiomyopathy on Families: an Exploratory Study

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Completed - verified February 24, 2017

Defining the Brain Phenotype of Children With Williams Syndrome

Condition:   Williams Syndrome
Intervention:  
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting - verified December 13, 2016

Vitamin K Supplement for Inhibition of the Progress in Aortic Valve Calcification

Condition:   Aortic Valve Calcification
Intervention:   Dietary Supplement: Vitamin K supplementation
Sponsor:   RWTH Aachen University
Completed - verified April 2017