Aortic Valve Stenosis Also called: Aortic Stenosis

Clinical Trial Finder

Many patients with aortic valve stenosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Comparison of Aortic Stenosis Subtypes After Balloon Aortic Valvuloplasty

Condition:   Aortic Valve Stenosis
Interventions:   Procedure: BAV;   Procedure: BAV + TAVR
Sponsor:   Heinrich-Heine University, Duesseldorf
Completed

Vivio AS (Aortic Stenosis) Detection Study

Condition:   Aortic Stenosis
Intervention:   Device: Vivio System
Sponsor:   Avicena LLC
Completed

JenaValve Pericardial TAVR System Aortic Stenosis Study

Condition:   Aortic Stenosis
Intervention:   Device: JenaValve Pericardial TAVR System
Sponsors:   JenaValve Technology, Inc.;   Cardiovascular Research Foundation, New York
Enrolling by invitation

Medtronic Evolut Transcatheter Aortic Valve Replacement in Low Risk Patients

Condition:   Aortic Valve Stenosis
Interventions:   Device: Medtronic Transcatheter Aortic Valve Replacement Systems;   Device: Surgical Aortic Valve Replacement (SAVR)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting

The Medtronic TAVR 2.0 US Clinical Study

Condition:   Aortic Valve Stenosis
Intervention:   Device: Medtronic Transcatheter Aortic Valve 2.0 Replacement System
Sponsor:   Medtronic Cardiovascular
Active, not recruiting

CoreValve™ Evolut R™ FORWARD Study

Condition:   Aortic Valve Stenosis
Intervention:   Device: Medtronic CoreValve™ Evolut R™ System
Sponsor:   Medtronic Cardiovascular
Active, not recruiting

Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement

Condition:   Severe Aortic Stenosis
Interventions:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI);   Device: Surgical Aortic Valve Replacement (SAVR)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting

Medtronic CoreValve Evolut R U.S. Clinical Study (Evolut 34R Addendum)

Condition:   Aortic Valve Stenosis
Intervention:   Device: CoreValve Evolut 34R TAVR system
Sponsor:   Medtronic Cardiovascular
Active, not recruiting

Safety & Efficacy Study of the Medtronic CoreValve® System-Treatment of Symptomatic Severe Aortic Stenosis With Significant Comorbidities in Extreme Risk Subjects Who Need Aortic Valve Replacement

Condition:   Severe Aortic Stenosis
Intervention:   Device: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting

Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study

Condition:   Bicuspid Aortic Valve
Intervention:   Device: Medtronic TAVR Systems
Sponsor:   Medtronic Cardiovascular
Active, not recruiting

FORWARD PRO Study Interventional Post-market Study With the Evolut™ PRO System

Condition:   Aortic Valve Stenosis
Intervention:   Device: Medtronic CoreValve™ Evolut™ PRO System (Evolut™ PRO System)
Sponsor:   Medtronic Cardiovascular
Active, not recruiting

ACURATE NEO/TF Transcatheter Heart Valves and Non-inferiority Versus Medtronic CoreValve Systems

Condition:   Aortic Stenosis
Interventions:   Device: Transcatheter Aortic Valve Implantation with ACURATE NEO/TF;   Device: Transcatheter Aortic Valve Implantation with Medtronic Evolut R/Pro
Sponsors:   National and Kapodistrian University of Athens;   Naval Hospital, Athens;   Silesian Centre for Heart Diseases;   Henry Dunant Hospital, Athens;   University General Hospital of Heraklion
Recruiting

Safety and Efficacy Comparison Of Two TAVI Systems in a Prospective Randomized Evaluation II

Condition:   Aortic Valve Stenosis
Interventions:   Device: Symetis ACURATE neo™ transfemoral TAVI system;   Device: Medtronic CoreValve Evolut R TAVI System
Sponsors:   Ceric Sàrl;   Symetis SA
Active, not recruiting

Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

Condition:   Aortic Valve Stenosis
Interventions:   Device: SAPIEN 3 THV;   Biological: Optimal Heart Failure Therapy
Sponsors:   Cardiovascular Research Foundation, New York;   Cardialysis BV;   Boston Biomedical Associates LLC
Recruiting

PERIGON Japan Trial

Condition:   Aortic Stenosis
Intervention:   Device: 17mm MDT-2215 aortic valve bioprosthesis
Sponsors:   Medtronic Cardiovascular;   Medtronic
Active, not recruiting

EDWARDS INTUITY Elite Valve System

Conditions:   Aortic Valve Disease;   Aortic Stenosis
Intervention:  
Sponsor:   Edwards Lifesciences
Completed

Optimize PRO Study

Condition:   Symptomatic Aortic Stenosis
Intervention:   Device: Evolut™ PRO System
Sponsor:   Medtronic Cardiovascular
Recruiting

EDWARDS INTUITY Valve System FOUNDATION Study

Conditions:   Aortic Valve Disease;   Aortic Stenosis;   Rapid Deployment Valves
Intervention:  
Sponsor:   Edwards Lifesciences
Completed

PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban

Conditions:   Aortic Valve Disease;   Aortic Valve Stenosis;   Aortic Valve Failure
Interventions:   Drug: Apixaban 5 MG;   Drug: Apixaban 2.5 MG;   Drug: Warfarin;   Device: On-X Aortic Mechanical Valve
Sponsors:   CryoLife, Inc.;   Duke Clinical Research Institute
Not yet recruiting

Functional and Quality of Life Improvement Following Transcatheter Heart Valve Implantation

Conditions:   Trans Catheter Aortic Valve;   Aortic Stenosis
Intervention:  
Sponsor:   Sheba Medical Center
Recruiting

Impact of Elastin Mediated Vascular Stiffness on End Organs

Conditions:   Williams Syndrome;   Supravalvular Aortic Stenosis;   Cardiovascular Disease
Intervention:  
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Revascularization in Patients Undergoing Transcatheter Aortic Valve Implantation

Conditions:   Coronary Artery Disease;   Aortic Valve Stenosis;   TAVI;   PCI
Intervention:   Procedure: PCI
Sponsors:   Rigshospitalet, Denmark;   Aarhus University Hospital;   Aalborg University Hospital;   Odense University Hospital;   Lund University Hospital;   Karolinska University Hospital;   Rikshospitalet University Hospital;   Haukeland University Hospital;   Helsinki University Central Hospital;   Tampere University Hospital;   Oulu University Hospital;   Turku University Hospital;   Kuopio University Hospital;   Sahlgrenska University Hospital, Sweden
Recruiting

Monitored Anesthesia Care vs. General Anesthesia for Transcatheter Aortic Valve Replacement

Condition:   Transcatheter Aortic Valve Replacement
Interventions:   Procedure: General Endotracheal Anesthesia;   Procedure: Monitored anesthesia care
Sponsor:   Medical University of South Carolina
Not yet recruiting

Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Cardiac Surgery

Conditions:   Coronary Artery Disease;   Postoperative Complications;   Aortic Valve Stenosis;   Mitral Valve Disease;   Aortic Aneurysm, Thoracic
Interventions:   Drug: Ferric carboxymaltose;   Other: Physiological saline
Sponsors:   Turku University Hospital;   Vifor Pharma
Recruiting

Identification of Genetic Causes of Calcific Aortic Valve Disease

Conditions:   Calcific Aortic Stenosis;   Calcific Aortic Stenosis - Bicuspid Valve;   Aortic Valve Disease;   Aortic Valve Calcification;   Aortic Diseases;   Aortic Aneurysm;   Aortic Valve Cusp Abnormality;   Aortic Valve Disease Mixed;   Aortic Valve Insufficiency
Intervention:   Procedure: Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study.
Sponsors:   Beth Israel Deaconess Medical Center;   Brigham and Women's Hospital
Recruiting

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

Condition:   Mitral Valve Failure
Interventions:   Device: Edwards SAPIEN 3 transcatheter heart valve;   Device: ASHI INTECC Astato XS 20
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

Condition:   CAD
Interventions:   Device: MRI scan x 1 Healthy Volunteer;   Device: MRI scan x 2 Healthy Volunteer;   Device: MRI scan x 2 - CAD patients;   Device: MRI scan x 2- non CAD patients
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

The Perceived Impact of Children s Risk Status for Hypertrophic Cardiomyopathy on Families: an Exploratory Study

Condition:   Cardiovascular Disease
Intervention:  
Sponsor:   National Human Genome Research Institute (NHGRI)
Completed

Non-Invasive Radiation Ablation in Patients With Hypertrophic CardioMyopathy: NIRA-HOCM

Condition:   Hypertrophic Cardiomyopathy
Intervention:   Device: Stereotactic body radiation therapy
Sponsors:   Barts & The London NHS Trust;   Barts Cardiovascular CTU (Queen Mary University of London);   Barts Charity
Not yet recruiting

A Prospective Incident Study of Arrhythmias in Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Intervention:  
Sponsor:   Mayo Clinic
Recruiting

A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM

Conditions:   Hypertrophic Cardiomyopathy;   Obstructive Hypertrophic Cardiomyopathy;   Non-obstructive Hypertrophic Cardiomyopathy
Intervention:   Drug: mavacamten
Sponsor:   MyoKardia, Inc.
Enrolling by invitation

Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Condition:   Obstructive Hypertrophic Cardiomyopathy
Interventions:   Drug: mavacamten;   Drug: Placebo
Sponsor:   MyoKardia, Inc.
Active, not recruiting

Prospective Evaluation Of Exercise-Induced Cardiac Conduction Instability In Predicting Ventricular Fibrillation Events In Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Intervention:   Diagnostic Test: Non-invasive ECG imaging - CardioInsight test
Sponsors:   Imperial College London;   Imperial College Healthcare NHS Trust;   Medtronic;   Barts & The London NHS Trust;   University of Oxford;   Daniel Bagshaw Trust
Not yet recruiting

Advancing Understanding of Transportation Options

Conditions:   Diabetic Retinopathy;   Macular Degeneration;   Glaucoma;   Retinitis Pigmentosa;   Vision Disorders;   Acute Coronary Syndrome;   Implantable Defibrillator User;   Congestive Heart Failure;   Hypertrophic Obstructive Cardiomyopathy;   Orthostatic Hypotension;   Syncope;   Presyncope;   Narcolepsy;   Dementia;   Multiple Sclerosis;   Parkinson Disease;   Brain Injuries;   Spinal Cord Injuries;   Stroke;   Vertigo;   Dizziness;   Seizures;   Substance Use;   Insulin Dependent Diabetes Mellitus;   Arthritis;   Foot--Abnormalities;   Chronic Obstructive Pulmonary Disease;   Obstructive Sleep Apnea;   End Stage Renal Disease;   Sleep Apnea;   Insomnia;   Restless Legs Syndrome
Interventions:   Behavioral: Driving Decision Aid;   Behavioral: Older Drivers Website
Sponsors:   University of Colorado, Denver;   National Institute on Aging (NIA)
Not yet recruiting

Defining the Brain Phenotype of Children With Williams Syndrome

Condition:   Williams Syndrome
Intervention:  
Sponsor:   National Institute of Mental Health (NIMH)
Recruiting