Aortic Valve Stenosis

Clinical Trial Finder

Many patients with aortic valve stenosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

ACURATE Neo™ AS Aortic Bioprosthesis for Implantation Using the ACURATE neoTM AS TF Transfemoral Delivery System in Patients With Severe Aortic Stenosis

Condition:   Aortic Stenosis
Intervention:   Device: Transcatheter aortic valve replacement
Sponsor:   Symetis SA
Not yet recruiting - verified September 2016

A Clinical Trial of Transcatheter Aortic Valves in Japanese Dialysis Patients

Condition:   Aortic Stenosis
Intervention:   Device: Transcatheter Aortic Valve Implantation (TAVI)
Sponsor:   Edwards Lifesciences
Not yet recruiting - verified September 2016

Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure

Conditions:   Cardiomyopathy, Hypertrophic;   Cardiomyopathy, Hypertrophic, Familial
Intervention:   Drug: Perhexiline
Sponsor:   Heart Metabolics Limited
Recruiting - verified September 2016

A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction

Condition:   Cardiomyopathy, Hypertrophic Obstructive
Intervention:   Drug: MYK-461
Sponsor:   MyoKardia, Inc.
Recruiting - verified August 2016

EDWARDS INTUITY Elite Valve System

Conditions:   Aortic Valve Disease;   Aortic Stenosis
Intervention:  
Sponsor:   Edwards Lifesciences
Recruiting - verified September 2016

The Medtronic TAVR 2.0 US Clinical Study

Condition:   Aortic Valve Stenosis
Intervention:   Device: Medtronic Transcatheter Aortic Valve 2.0 Replacement System
Sponsor:   Medtronic Cardiovascular
Recruiting - verified September 2016

Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

Condition:   Aortic Valve Stenosis
Interventions:   Device: SAPIEN 3 THV;   Biological: Optimal Heart Failure Therapy
Sponsors:   Cardiovascular Research Foundation, New York;   Cardialysis BV;   Boston Biomedical Associates LLC
Recruiting - verified September 2016

Feasibility of Transcatheter Aortic Valve Replacement in Low-Risk Patients With Symptomatic, Severe Aortic Stenosis

Condition:   Aortic Stenosis
Interventions:   Device: Transfemoral TAVR;   Device: SAVR
Sponsor:   Medstar Health Research Institute
Recruiting - verified September 2016

Cerebral Protection to Reduce Cerebral Embolic Lesions After Transcatheter Aortic Valve Implantation

Condition:   Symptomatic Aortic Stenosis
Interventions:   Device: Embolic Protection Device;   Procedure: ranscatheter aortic valve implantation (TAVI)
Sponsor:   Keystone Heart
Recruiting - verified September 2016

Biological Variation of Cardiac Biomarkers in Aortic Valve Stenosis

Condition:   Aortic Valve Stenosis
Intervention:   Other: No intervention
Sponsor:   Maastricht University Medical Center
Recruiting - verified September 2016

A Study Evaluating the Effects of Ataciguat (HMR1766) on Aortic Valve Calcification

Condition:   Aortic Valve Stenosis
Interventions:   Drug: Ataciguat (HMR1766);   Other: Placebo Comparator: Matching Placebo
Sponsors:   Mayo Clinic;   Sanofi;   National Institutes of Health (NIH)
Recruiting - verified September 2016

Individualized Early Risk Assessment for Heart Diseases

Conditions:   Cardiomyopathy, Hypertrophic;   Cardiomyopathy, Dilated
Intervention:   Other: Skin biopsy, genotyping and disease phenotyping
Sponsor:   Universitätsklinikum Hamburg-Eppendorf
Recruiting - verified September 2016

Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-461

Condition:   Hypertrophic Cardiomyopathy
Intervention:   Drug: MYK-461
Sponsor:   MyoKardia, Inc.
Completed - verified September 2016

Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic Access

Condition:   Aortic Valve Stenosis
Intervention:   Procedure: CA-TAVR
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Enrolling by invitation - verified September 2016

Pilot Trial: Comparison of Flow Patterns

Conditions:   Aortic Valve Stenosis;   Aortic Valve Insufficiency
Intervention:   Radiation: Cardiac CT-scan
Sponsors:   Medical University of Vienna;   University College, London
Recruiting - verified September 2016

Symetis ACURATE Neo™ Valve Implantation SAVI TF Registry

Condition:   Aortic Stenosis
Intervention:  
Sponsor:   Symetis SA
Active, not recruiting - verified September 2016

Early Aortic Valve Lipoprotein(a) Lowering Trial

Condition:   Aortic Stenosis and Lipoprotein(a) Levels
Interventions:   Drug: Extended release Niacin;   Drug: Placebo Comparator
Sponsors:   George Thanassoulis;   Jewish General Hospital;   Laval University;   Quebec Heart Institute
Recruiting - verified September 2016

ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)

Conditions:   Aortic Stenosis;   Mitral Stenosis;   Aortic Valve Insufficiency;   Mitral Valve Insufficiency;   Heart Failure
Intervention:   Device: Edwards Aortic and Mitral Bioprostheses Models 11000A and 11000M
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified September 2016

Surgical Treatment of Aortic Stenosis With a Next Generation, Rapid Deployment Surgical Aortic Valve

Conditions:   Aortic Valve Stenosis;   Aortic Valve Stenosis With Insufficiency;   Regurgitation, Aortic Valve;   Aortic Valve Incompetence
Intervention:   Device: EDWARDS INTUITY valve
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified September 2016

Compassionate Use of Triheptanoin (C7) for Inherited Disorders of Energy Metabolism

Conditions:   Very Long-chain acylCoA Dehydrogenase (VLCAD) Deficiency;   Carnitine Palmitoyltransferase Deficiencies (CPT1, CPT2);   Mitochondrial Trifunctional Protein Deficiency;   Long-chain Hydroxyacyl-CoA Dehydrogenase Deficiency;   Glycogen Storage Disorders;   Pyruvate Carboxylase Deficiency Disease;   ACYL-CoA DEHYDROGENASE FAMILY, MEMBER 9, DEFICIENCY of;   Barth Syndrome
Intervention:   Drug: triheptanoin
Sponsors:   University of Pittsburgh;   Ultragenyx Pharmaceutical Inc
Available - verified September 2016

Study to Develop a Non-invasive Marker for Monitoring Myocardial Fibrosis

Conditions:   Hypertrophic Cardiomyopathy;   Acute Coronary Syndrome
Intervention:   Radiation: 99mTc-NC100692
Sponsor:   Ottawa Heart Institute Research Corporation
Recruiting - verified September 2016

Carpentier-Edwards PERIMOUNT Magna Ease Pericardial Bioprosthesis, Model 3300TFX

Conditions:   Coronary Artery Disease;   Aortic Valve Disorder;   Heart Failure;   Aortic Valve Stenosis;   Aortic Valve Insufficiency
Intervention:   Device: Implantation of CEP Magna Ease Model 3300TFX
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified September 2016