Aortic Valve Stenosis

Clinical Trial Finder

Many patients with aortic valve stenosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

The Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis

Condition:   Aortic Stenosis
Interventions:   Procedure: Surgical aortic valve replacement (SAVR);   Device: Transcatheter Aortic Valve Replacement (TAVR)
Sponsor:   Edwards Lifesciences
Not yet recruiting - verified February 2016

Valve Leaflet Motion in Sutureless Bioprosthetic Aortic Valves

Conditions:   Aortic Valve Stenosis;   Heart Valve Disease
Intervention:   Other: 4-dimensional volume-rendered computed tomography
Sponsors:   Karolinska University Hospital;   Karolinska Institutet
Recruiting - verified January 2016

Perceval Sutureless Implant Versus Standard-Aortic Valve Replacement

Conditions:   Aortic Valve Disease;   Aortic Stenosis
Interventions:   Device: Perceval valve;   Device: other stented biological valve
Sponsor:   LivaNova
Not yet recruiting - verified February 2016

REMODEL: Hypertensive Heart Disease

Conditions:   Left Ventricular Hypertrophy;   Hypertension;   Myocardial Fibrosis
Interventions:   Other: Cardiovascular Magnetic Resonance;   Other: Echocardiogram;   Other: Electrocardiogram;   Device: Ambulatory Blood Pressure Monitoring
Sponsor:   National Heart Centre Singapore
Recruiting - verified January 2016

Mobilization of Endothelial Progenitor Cells and Aspirin

Condition:   Hypertrophic Obstructive Cardiomyopathy
Intervention:   Drug: Aspirin
Sponsor:   Ottawa Heart Institute Research Corporation
Not yet recruiting - verified January 2016


Conditions:   Aortic Valve Disease;   Aortic Stenosis
Interventions:   Device: EDWARDS INTUITY Valve System, Model 8300A;   Device: Stented Aortic Bioprostheses
Sponsor:   Edwards Lifesciences
Completed - verified January 2016

CoreValve™ Evolut R™ FORWARD Study

Condition:   Aortic Valve Stenosis
Intervention:   Device: Medtronic CoreValve™ Evolut R™ System
Sponsor:   Medtronic Cardiovascular
Recruiting - verified February 2016

Anti-Thrombotic Strategy After Trans-Aortic Valve Implantation for Aortic Stenosis

Conditions:   Symptomatic Aortic Stenosis;   Eligible for Transcatheter Aortic Valve Replacement
Interventions:   Drug: Apixaban;   Drug: Standard of care
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Action Research Group;   Bristol-Meyers Squibb & Pfizer
Not yet recruiting - verified December 2015

Valvular Aortic Stenosis: Study of Myocardiac Fibrosis by Magnetic Resonance Imagery

Condition:   Aortic Valve Stenosis
Intervention:   Procedure: Valvular aortic stenosis surgery
Sponsor:   Assistance Publique - Hôpitaux de Paris
Completed - verified January 2016

Safety and Performance Study of the Edwards CENTERA-EU Self-Expanding Transcatheter Heart Valve

Condition:   Aortic Valve Disease
Intervention:   Device: Edwards CENTERA Self-Expanding Transcatheter Heart Valve
Sponsors:   Edwards Lifesciences;   Medstar Research Institute;   European Cardiovascular Research Center;   University of British Columbia
Recruiting - verified January 2016

Neuroprotection in Patients Undergoing Aortic Valve Replacement

Conditions:   Aortic Stenosis;   Brain Infarction;   Cerebrovascular Accident;   Stroke
Interventions:   Device: Embol-X Embolic Protection Device;   Device: CardioGard Cannula
Sponsors:   Icahn School of Medicine at Mount Sinai;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified January 2016


Conditions:   Aortic Valve Disease;   Aortic Stenosis;   Rapid Deployment Valves
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified February 2016

Effect of Eleclazine (GS-6615) on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Interventions:   Drug: Eleclazine;   Drug: Placebo
Sponsor:   Gilead Sciences
Recruiting - verified January 2016

Quality of Care in AS IMPULSE Study

Condition:   Aortic Valve Stenosis
Intervention:   Other: Nurse based at echo facility will inform referring physician within one week that their Patient was diagnosed with severe aortic Stenosis.
Sponsors:   Institut für Pharmakologie und Präventive Medizin;   Edwards Lifesciences
Recruiting - verified January 2016

CoreValve VIVA Study Evaluation of the Clinical Outcomes of CoreValve in Degenerative Surgical Aortic Bioprosthesis.

Condition:   Aortic Valve Stenosis
Intervention:   Device: CoreValve Transcatheter Valve
Sponsor:   Medtronic Bakken Research Center
Recruiting - verified January 2016

Balloon Expandable Transcatheter Aortic Valve Implantation Without Predilation of the Aortic Valve

Condition:   Aortic Valve Stenosis
Interventions:   Procedure: BAV;   Procedure: no BAV
Sponsor:   Institut für Pharmakologie und Präventive Medizin
Recruiting - verified January 2016

Aortic Valve and Root Measurements Under Real-Time 3-Dimensional Visualization During Angiography

Conditions:   Coronary Artery Disease;   Aortic Stenosis
Intervention:   Radiation: Real-time 3-dimensional DynaCT
Sponsor:   Binita Shah
Recruiting - verified January 2016

CGA-TAVI Registry to Evaluate the Predictive Value of a CGA in Predicting TAVI Outcomes

Condition:   Aortic Valve Stenosis
Intervention:   Other: TAVI
Sponsor:   Institut für Pharmakologie und Präventive Medizin
Active, not recruiting - verified January 2016

The PARTNER II Trial: Placement of AoRTic TraNscathetER Valves

Condition:   Symptomatic Severe Aortic Stenosis
Interventions:   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis;   Device: TAVR Implantation of the Transcatheter Aortic Valve Prosthesis
Sponsor:   Edwards Lifesciences
Active, not recruiting - verified February 2016

The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome

Conditions:   Velocardiofacial Syndrome;   Williams Syndrome;   Fragile X Syndrome
Intervention:   Drug: methylphenidate, fluoxetin, risperidone
Sponsor:   The Chaim Sheba Medical Center
Recruiting - verified January 2016