Aortic Valve Stenosis Also called: Aortic Stenosis

Clinical Trial Finder

Many patients with aortic valve stenosis are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Severe Aortic Valve Stenosis and Concomitant Coronary Artery Disease in Patients Undergoing TAVI

Conditions:   Aortic Valve Stenosis;   Coronary Artery Disease
Intervention:   Other: Coronary artery disease
Sponsor:   Örebro County Council
Active, not recruiting

Cardiovascular Rehabilitation in Patients With Severe Aortic Stenosis Submitted to Valvar Correction

Condition:   Aortic Valve Stenosis
Intervention:   Behavioral: cardiovascular rehabilitation program
Sponsors:   Irmandade Santa Casa de Misericórdia de Porto Alegre;   Federal University of Health Science of Porto Alegre
Not yet recruiting

Targeted Testing for ATTR Among Aortic Stenosis Patients-Pilot

Conditions:   Aortic Valve Stenosis;   Cardiac Amyloidosis
Intervention:   Diagnostic Test: PYP scan
Sponsors:   University of Texas Southwestern Medical Center;   Mid America Heart Institute
Not yet recruiting

The PARTNER 3 - Trial - The Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis

Condition:   Aortic Stenosis
Interventions:   Procedure: Surgical aortic valve replacement (SAVR);   Device: Transcatheter Aortic Valve Replacement (TAVR)
Sponsor:   Edwards Lifesciences
Active, not recruiting

HLT Meridian Valve CE Mark Trial

Condition:   Aortic Valve Stenosis
Intervention:   Device: HLT® Transcatheter System
Sponsor:   HLT Inc.

A pragmatiC sTrategy to Promote actIVity and Enhance Quality of Life AFTER Transcatheter Aortic Valve Replacement

Condition:   Aortic Valve Stenosis
Interventions:   Behavioral: Daily Activity Goal;   Behavioral: Resistance Exercises;   Behavioral: Daily Activity Recording
Sponsors:   Vanderbilt University Medical Center;   Edwards Lifesciences
Active, not recruiting

Phono- and Electrocardiogram Assisted Detection of Valvular Disease

Conditions:   Aortic Valve Stenosis;   Mitral Regurgitation;   Heart Murmurs;   Valvular Heart Disease
Interventions:   Diagnostic Test: AS Algorithm 1;   Diagnostic Test: AS Algorithm 2;   Diagnostic Test: MR Algorithm 1;   Diagnostic Test: MR Algorithm 2
Sponsors:   University of California, San Francisco;   Eko Devices, Inc.
Active, not recruiting

Portico NG Approval Study

Condition:   Symptomatic Severe Aortic Stenosis
Intervention:   Device: Portico™ NG Valve and FlexNav™ Delivery System
Sponsor:   Abbott Medical Devices

First in Man Study of the JenaValve TAVI Plus System Transfemoral

Conditions:   Aortic Valve Stenosis;   Heart Valve Diseases;   Heart Diseases;   Cardiovascular Diseases
Intervention:   Device: JenaValve Pericardial TAVR System
Sponsor:   JenaValve Technology, Inc.

Vascular Closure Device in Transcatheter Aortic Valve Replacement

Condition:   Aortic Valve Stenosis
Intervention:   Device: MANTA vascular closure device
Sponsor:   Karolinska University Hospital

Prehabilitation for Patients Undergoing Transcatheter Aortic Valve Replacement

Condition:   Aortic Valve Stenosis
Intervention:   Other: Pre-habilitation
Sponsors:   WellSpan Health;   Lancaster General Hospital

Optimize PRO Study

Condition:   Symptomatic Aortic Stenosis
Intervention:   Device: Evolut™ PRO and Evolut™ PRO+ System
Sponsor:   Medtronic Cardiovascular

PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban

Conditions:   Aortic Valve Disease;   Aortic Valve Stenosis;   Aortic Valve Failure
Interventions:   Drug: Apixaban 5 MG;   Drug: Apixaban 2.5 MG;   Drug: Warfarin;   Device: On-X Aortic Mechanical Valve
Sponsors:   CryoLife, Inc.;   Duke Clinical Research Institute

Optimal Timing of Transcatheter Aortic Valve Implantation and Percutaneous Coronary Intervention - The TAVI PCI Trial

Conditions:   Aortic Stenosis;   Coronary Artery Disease;   TAVI;   PCI
Interventions:   Procedure: PCI before TAVI;   Procedure: PCI after TAVI
Sponsor:   University of Zurich
Not yet recruiting

Radial Versus Femoral Secondary Access During TAVI

Conditions:   Aortic Stenosis;   Aortic Valve Disease;   Vascular Access Complication
Interventions:   Procedure: Secondary Radial Artery Access;   Procedure: Secondary Femoral Artery Access
Sponsor:   Carilion Clinic

Acute Kidney Injury Genomics and Biomarkers in TAVR Study

Conditions:   Acute Kidney Injury;   Renal Insufficiency, Chronic;   Heart Failure;   Myocardial Infarction;   Arrhythmias, Cardiac;   Stroke
Intervention:   Procedure: Transcatheter Aortic Valve Replacement
Sponsor:   University of Texas Southwestern Medical Center
Active, not recruiting

Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes

Conditions:   Murmur, Heart;   Aortic Valve Stenosis;   Tricuspid Regurgitation;   Mitral Regurgitation;   Innocent Murmurs;   Heart Murmurs
Intervention:   Device: Use of Eko CORE and Eko DUO electronic stethoscopes
Sponsor:   Eko Devices, Inc.
Not yet recruiting

Structural Heart and Valve Network PROSPECTIVE Registry

Conditions:   Mitral Valve Regurgitation;   Heart Failure;   Heart Valve Disease;   Tricuspid Valve Regurgitation;   Aortic Valve Stenosis
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

Condition:   Mitral Valve Failure
Interventions:   Device: Edwards SAPIEN 3 transcatheter heart valve;   Device: ASHI INTECC Astato XS 20
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Fluid REsponsiveness and Arterial ELASTANCE in Patients With Septic Shock or After Aortic Surgery

Conditions:   Shock, Septic;   Hyperlactatemia;   Oliguria;   Aortic Aneurysm, Abdominal;   Aortic Aneurysm, Ruptured;   Aortic Stenosis
Intervention:   Drug: Fluid challenge
Sponsor:   Central Hospital, Nancy, France

Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

Condition:   CAD
Interventions:   Device: MRI scan x 1 Healthy Volunteer;   Device: MRI scan x 2 Healthy Volunteer;   Device: MRI scan x 2 - CAD patients;   Device: MRI scan x 2- non CAD patients
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)

Study of Efficacy of Oral Sacubitril/Valsartan in Adult Patients With Non-obstructive Hypertrophic Cardiomyopathy

Condition:   Cardiomyopathy, Hypertrophic
Interventions:   Drug: LCZ696;   Drug: Placebo
Sponsor:   Novartis Pharmaceuticals

Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Condition:   Obstructive Hypertrophic Cardiomyopathy
Interventions:   Drug: mavacamten;   Drug: Placebo
Sponsor:   MyoKardia, Inc.

Efficacy of Risk Assessment for Sudden Cardiac Death in Patients With Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Intervention:   Device: Cardioverter-defibrillator
Sponsor:   Poznan University of Medical Sciences

Exercise in Genetic Cardiovascular Conditions

Conditions:   Hypertrophic Cardiomyopathy;   Long QT Syndrome
Sponsors:   Yale University;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting