Angina

Clinical Trial Finder

Many patients with angina are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

A Study to Evaluate the Effects of Azilsartan on Coronary Artery Plaque in Essential Hypertensive Patients With Stable Angina and Dyslipidemia

Condition:   Essential Hypertension With Stable Angina and Dyslipidemia
Intervention:   Drug: Azilsartan
Sponsor:   Takeda
Not yet recruiting - verified March 2015

Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease

Condition:   Coronary Artery Disease
Interventions:   Procedure: Computed tomography angiography (cardiac CT);   Procedure: Invasive coronary angiography (ICA)
Sponsor:   Charite University, Berlin, Germany
Not yet recruiting - verified March 2015

RuSsian RegisTry of Acute CoronaRy SyndromE TreAtMent and Approach in Dual Antiplatelet Therapy

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   AstraZeneca
Not yet recruiting - verified March 2015

Effect of GS-6615 on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Interventions:   Drug: GS-6615;   Drug: Placebo
Sponsor:   Gilead Sciences
Recruiting - verified March 2015

Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Pilot Study in Healthy Volunteers

Conditions:   Myocardial Infarction;   Inflammation;   Acute Coronary Syndrome (ACS);   Reperfusion Injury
Interventions:   Biological: Salmonella typhi vaccine (Typhim Vi®);   Drug: Oxygen (Oxymask®);   Drug: Atorvastatin
Sponsors:   Karolinska Institutet;   University Hospital, Linkoeping
Recruiting - verified March 2015

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified March 2015

COBRA SHIELD OCT Study

Condition:   Stable Angina
Interventions:   Drug: Aspirin;   Device: Resolute Integrity DES;   Device: COBRA PzF;   Drug: DAPT
Sponsors:   CeloNova BioSciences, Inc.;   ClinLogix. LLC
Terminated - verified March 2015

Copeptin Testing During Pre-hospital Care in the Treatment of Chest Pain Suggestive of Acute Coronary Syndrome

Condition:   Chest Pain
Interventions:   Biological: Blood work in the ambulance;   Biological: Blood work upon arrival in the emergency room;   Biological: Blood work at 3 hours post-arrival in the emergency room
Sponsor:   Centre Hospitalier Universitaire de Nīmes
Not yet recruiting - verified March 2015

DIAMOND - Dual Antiplatelet Therapy to Reduce Myocardial Injury

Condition:   Coronary Artery Disease
Interventions:   Drug: Ticagrelor;   Drug: Placebo
Sponsors:   University of Edinburgh;   AstraZeneca
Recruiting - verified March 2015

Efficacy and Safety of New Generation Drug Eluting Stents Associated With an Ultra Short Duration of Dual Antiplatelet Therapy. Design of the Short Duration of Dual antiplatElet Therapy With SyNergy II Stent in Patients Older Than 75 Years Undergoing Percutaneous Coronary Revascularization.

Conditions:   Stable Angina;   Silent Myocardial Ischemia;   Acute Coronary Syndrome
Interventions:   Procedure: Percutaneous Coronary Intervention (PCI) with short DAPT duration with Synergy II stent;   Procedure: Percutaneous Coronary Intervention (PCI) with short DAPT duration with Omega stent;   Procedure: Percutaneous Coronary Intervention (PCI) with short DAPT duration with Rebel stent
Sponsor:   Ceric Sàrl
Recruiting - verified December 2014

Short-term Dual Anti Platelet Therapy in Patients With ACS Treated With the COMBO Dual-therapy Stent

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Treatment 3 months DAPT;   Drug: Treatment 12 months DAPT
Sponsor:   Diagram B.V.
Recruiting - verified March 2015

HARMONEE - Japan-USA Harmonized Assessment by Randomized, Multi-Center Study of OrbusNEich's Combo StEnt

Conditions:   Coronary Arteriosclerosis;   Non ST Segment Elevation Acute Coronary Syndrome
Interventions:   Device: OrbusNeich Combo stent™;   Device: Everolimus Eluting Stent (EES)
Sponsors:   OrbusNeich;   OrbusNeich Medical K.K.;   Duke Clinical Research Institute
Recruiting - verified March 2015

Statin and Angiotensin-converting Enzyme Inhibitor on Symptoms in Patients With SCAD

Condition:   Coronary Artery Dissection, Spontaneous
Interventions:   Drug: ramipril;   Drug: rosuvastatin;   Drug: placebo
Sponsor:   Cardiology Research UBC
Recruiting - verified July 2014

Routine Versus Selective Use of FFR to Guide PCI

Conditions:   Acute Coronary Syndrome;   Coronary Atherosclerosis;   Angina, Unstable
Intervention:   Device: Fractional Flow Reserve (FFR)
Sponsors:   Cardiology Research UBC;   Provincial Health Services Authority
Terminated - verified March 2015

Cardiovascular Outcomes Following Treatment With Ertugliflozin in Participants With Type 2 Diabetes Mellitus and Established Vascular Disease (MK-8835-004)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Ertugliflozin;   Drug: Placebo
Sponsors:   Merck Sharp & Dohme Corp.;   Pfizer
Recruiting - verified March 2015

The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified March 2015

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified March 2015

Specimen Procurement& Data Collection Protocol for The Rapid Evaluation of Possible Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Intervention:   Other: OBSERVATIONAL REGISTRY
Sponsor:   Henry Ford Health System
Recruiting - verified March 2015

Testing Responsiveness to Platelet Inhibition on Chronic Antiplatelet Treatment For Acute Coronary Syndromes Trial

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Prasugrel;   Drug: Clopidogrel
Sponsor:   Klinikum der Universitaet Muenchen
Recruiting - verified March 2015

Prevention of Cardiovascular Events by Antiplatelet Agents After Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified March 2015

Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Placebo;   Drug: Linagliptin
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified March 2015

Atorvastatin Versus Rosuvastatin on Contrast Induced Acute Kidney Injury (PRATO-ACS 2)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Rosuvastatin;   Drug: Atorvastatin
Sponsor:   Centro Cardiopatici Toscani
Recruiting - verified March 2015

High-Sensitivity Troponin in the Evaluation of Patients With Acute Coronary Syndrome

Conditions:   Acute Coronary Syndrome;   Myocardial Infarction
Intervention:   Device: High-sensitivity troponin I assay
Sponsors:   University of Edinburgh;   NHS Lothian;   NHS Greater Glasgow and Clyde;   Abbott Diagnostics Division
Recruiting - verified March 2015

PROMISE Substudy to Assess For Effective Dose of Radiation (PROMISE-SAFER) Specific Aim 3b

Conditions:   Chest Pain;   Coronary Artery Disease;   Angina
Intervention:  
Sponsors:   Kaiser Permanente;   Columbia University
Active, not recruiting - verified March 2015

Lipoprotein Apheresis in Refractory Angina Study

Conditions:   Refractory Angina;   Raised Lipoprotein(a)>50mg/dL or >500mg/L
Interventions:   Other: Lipoprotein Apheresis;   Other: Sham Apheresis
Sponsors:   Imperial College London;   National Institute for Health Research, United Kingdom
Active, not recruiting - verified February 2013

An Efficacy and Outcome Study of Supplemental Oxygen Treatment in Patients With Suspected Myocardial Infarction

Conditions:   Acute Coronary Syndrome;   Non-ST Elevation (NSTEMI) Myocardial Infarction;   Acute ST Segment Elevation Myocardial Infarction;   Angina, Unstable
Intervention:   Drug: Oxygen
Sponsors:   Karolinska Institutet;   Swedish Heart Lung Foundation;   Swedish Foundation for Strategic Research;   The Swedish Research Council
Recruiting - verified March 2015

Complete vs Culprit-only Revascularization to Treat Multi-vessel Disease After Primary PCI for STEMI

Conditions:   Acute Myocardial Infarction;   Coronary Artery Disease;   Percutaneous Coronary Intervention
Intervention:   Procedure: Complete Revascularization Strategy
Sponsor:   Population Health Research Institute
Recruiting - verified March 2015

Does Optical Coherence Tomography Optimise Results of Stenting

Condition:   Acute Coronary Syndromes
Intervention:   Procedure: OCT
Sponsor:   Centre Hospitalier Universitaire de Besancon
Recruiting - verified March 2015

Single Long vs Two Short Overlapping Bioabsorbable Polymer DES

Condition:   Coronary Artery Disease
Intervention:   Device: implantation of a bioabsorbable polymer DES
Sponsor:   Azienda Ospedaliero Universitaria Maggiore della Carita
Recruiting - verified March 2015

The Impact of Gratitude on Biology and Behavior in Persons With Heart Disease

Conditions:   Myocardial Infarction;   Unstable Angina
Intervention:  
Sponsors:   Massachusetts General Hospital;   University of California, Berkeley
Completed - verified March 2015

Citalopram for Sx/Util in Acute Coronary Syndrome Patients

Condition:   Acute Coronary Syndrome
Intervention:   Drug: Citalopram
Sponsor:   Henry Ford Health System
Not yet recruiting - verified August 2012

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab SAR236553 (REGN727)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Other: placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified March 2015

HeartTrends Heart Rate Variability (HRV) Algorithm for the Diagnosis of Myocardial Ischemia

Condition:   Ischemic Heart Disease
Intervention:  
Sponsor:   Sheba Medical Center
Completed - verified March 2015

Acute Versus Subacute Angioplasty in Patients With NON-ST-Elevation Myocardial Infarction

Condition:   Myocardial Infarction
Intervention:   Procedure: Group I: Primary PCI
Sponsor:   Aarhus University Hospital Skejby
Recruiting - verified March 2015

A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Brilinta

Condition:   Acute Coronary Syndromes
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified March 2015

Antiplatelet Therapy Guided by Thrombelastography in Patients With Acute Coronary Syndromes (TEGCOR Study)

Conditions:   Thrombosis;   Coronary Artery Disease
Interventions:   Drug: Prasugrel;   Drug: Clopidogrel
Sponsor:   Indiana University
Recruiting - verified March 2015

Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.

Condition:   Smoking Cessation
Interventions:   Drug: placebo;   Drug: varenicline tartrate;   Drug: bupropion hydrochloride;   Drug: Nicotine Replacement Therapy Patch
Sponsor:   Pfizer
Recruiting - verified March 2015

BIOFLOW-III All-comers Orsiro Safety and Performance Registry

Conditions:   Coronary Artery Disease;   Myocardial Ischemia
Intervention:  
Sponsor:   Biotronik AG
Active, not recruiting - verified March 2015

Cardiovascular and Torsades de Pointes Monitoring for Pazopanib

Condition:   Carcinoma, Renal Cell
Interventions:   Drug: Pazopanib;   Drug: Other anti-VEGFs
Sponsor:   GlaxoSmithKline
Completed - verified March 2015

A Study of RoActemra/Actemra (Tocilizumab) in Comparison to Etanercept in Patients With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors

Condition:   Cardiovascular Disease, Rheumatoid Arthritis
Interventions:   Drug: etanercept;   Drug: tocilizumab [RoActemra/Actemra]
Sponsor:   Hoffmann-La Roche
Active, not recruiting - verified March 2015

CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: linagliptin;   Drug: glimepiride;   Drug: linagliptin placebo;   Drug: glimepride placebo
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting - verified March 2015

BI 10773 (Empagliflozin) Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME).

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: BI 10773 low dose;   Drug: Placebo BI 10773 high dose;   Drug: BI 10773 high dose;   Drug: Placebo BI 10773 low dose;   Drug: Placebo BI 10773 low dose;   Drug: Placebo BI 10773 high dose
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Active, not recruiting - verified March 2015

Post-authorization Safety Study of Etoricoxib and Other Anti-inflammatory Therapies in European Patients With Ankylosing Spondylitis (MK-0663-163)

Condition:   Ankylosing Spondylitis
Intervention:  
Sponsor:   Merck Sharp & Dohme Corp.
Active, not recruiting - verified March 2015

A Study With Aleglitazar in Patients With a Recent Acute Coronary Syndrome and Type 2 Diabetes Mellitus

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Aleglitazar;   Drug: Placebo
Sponsor:   Hoffmann-La Roche
Completed - verified March 2015

AngelMed for Early Recognition and Treatment of STEMI

Conditions:   Acute Myocardial Infarction (AMI);   Coronary Occlusion;   Acute Coronary Syndrome
Intervention:   Device: AngelMed Guardian System
Sponsors:   Angel Medical Systems;   Symbios Clinical
Active, not recruiting - verified July 2013

French Registry of Acute Coronary Syndrome

Condition:   Acute Myocardial Infarction
Intervention:   Other: Blood sample
Sponsors:   Assistance Publique - Hôpitaux de Paris;   French Cardiology Society
Active, not recruiting - verified March 2015

A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease

Condition:   Moderate Risk of CVD
Interventions:   Drug: Aspirin (Acetylsalicylic acid, BAYE4465);   Drug: Placebo
Sponsor:   Bayer
Active, not recruiting - verified March 2015

Paclitaxel Eluting Balloon Versus Drug Eluting Stent in Native Coronary Artery Stenoses of Diabetic Patients

Conditions:   Coronary Stenosis;   Diabetes Mellitus
Interventions:   Device: Paclitaxel Eluting Balloon;   Device: paclitaxel eluting stent;   Device: bare metal stent
Sponsors:   Heart Centre Rotenburg;   B. Braun Medical SA
Active, not recruiting - verified March 2015

Testosterone and Myocardial Perfusion in CHD

Condition:   Coronary Heart Disease
Intervention:   Drug: Testosterone undecanoate
Sponsors:   Imperial College London;   Organon
Completed - verified October 2005

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