Clinical Trial Finder

Many patients with angina are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Stable Angina Management and Treatment

Conditions:   Stable Angina;   Coronary Artery Disease
Sponsor:   Silesian Centre for Heart Diseases

Coronary Arteriogenetic Heparinized Exercise

Conditions:   Refractory Angina;   Chronic Stable Angina
Interventions:   Other: Physical rehabilitation;   Drug: Heparin;   Other: Placebo
Sponsors:   Clinical Centre of Serbia;   Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy

REDUCER-I: An Observational Study of the Neovasc Reducer™ System

Conditions:   Angina Pectoris;   Angina Pectoris, Stable;   Chronic Stable Angina
Intervention:   Device: Neovasc Reducer System
Sponsor:   Neovasc Inc.

Effects of Integrated Treatment by Traditional Chinese and Western Medicine in Reducing Cardiovascular Events

Conditions:   Angina Pectoris;   Coronary Artery Disease;   Coronary Disease;   Heart Disease;   Cardiovascular Disease;   Chest Pain;   Pain;   Signs and Symptoms;   Arteriosclerosis
Sponsor:   Changchun University of Chinese Medicine

Neuregulin-1 in Patient With Different Forms of Cardiovascular Diseases: a Pilot Study

Conditions:   Heart Failure With Preserved Ejection Fraction;   Microvascular Angina;   Pulmonary Hypertension;   Heart Failure With Reduced Ejection Fraction
Intervention:   Diagnostic Test: Neuregulin-1β level in plasma
Sponsors:   I.M. Sechenov First Moscow State Medical University;   Universiteit Antwerpen;   University of Basel

Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

Conditions:   Prediabetic State;   Atherosclerosis;   Metformin
Interventions:   Drug: Metformin XR;   Drug: Placebo
Sponsor:   VA Office of Research and Development

Prospective Multicenter Study on the Identification of Genetic Abnormalities Predisposing to Vasospasm From a Privileged Model: the Primary Raynaud's Phenomenon

Conditions:   Primary Raynaud's Phenomenon (PR);   Genetic Mutations Causing PR;   Study of Patients and Their Relatives (With or Without Primary PR)
Intervention:   Genetic: Demonstration of genetic mutations causing Raynaud's phenomenon
Sponsor:   Nantes University Hospital

Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia

Condition:   Eligible Men or Women Considered High Risk for Atherosclerotic Cardiovascular Disease (CVD)
Interventions:   Drug: Epanova® (omega-3 carboxylic acids);   Drug: corn oil control
Sponsors:   AstraZeneca;   The Cleveland Clinic;   IQVIA RDS Inc.
Active, not recruiting

Use of Ixmyelocel-T (Formerly Catheter-based Cardiac Repair Cell [CRC]) Treatment in Patients With Heart Failure Due to Dilated Cardiomyopathy

Condition:   Dilated Cardiomyopathy
Interventions:   Biological: Ixmyelocel-T;   Other: Vehicle Control
Sponsor:   Vericel Corporation

The Lipid-Rich Plaque Study

Conditions:   Coronary Artery Disease;   Atherosclerosis
Intervention:   Device: NIRS-IVUS Imaging (TVC Imaging System)
Sponsors:   InfraReDx;   Medstar Health Research Institute

The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial

Condition:   Coronary Artery Disease
Interventions:   Procedure: MICS CABG;   Procedure: Conventional CABG
Sponsors:   Ottawa Heart Institute Research Corporation;   London Health Sciences Centre;   Heart Center Leipzig - University Hospital;   Fortis Escorts Heart Institute;   The Methodist Hospital System;   Carolinas Medical Center;   Gundersen Lutheran Health System;   Jilin Heart Hospital;   Far Eastern Memorial Hospital;   Medtronic;   Apollo Hospitals;   Ichinomiya-Nishi Hospital;   Fresno Heart and Surgical Hospital
Active, not recruiting

Improvement of Postoperative Immunosuppression in Patients Receiving Coronary Artery Bypass Grafting by TEAS

Condition:   Immunosuppression
Interventions:   Device: TEAS+GA group;   Device: Sham TEAS+GA group
Sponsors:   ShuGuang Hospital;   Guangdong Provincial People's Hospital

Drug Coated Balloon for Side Branch Treatment vs. Conventional Approach in True Bifurcation Coronary Disease: PRO-DAVID

Conditions:   Stable Angina;   Ischemic Heart Disease;   Coronary Artery Disease;   Unstable Angina;   NSTEMI - Non-ST Segment Elevation MI
Interventions:   Procedure: Provisional DCB approach PCI procedure;   Procedure: Standard provisional approach PCI procedure
Sponsor:   Clinical Hospital Center Rijeka
Not yet recruiting

Imaging vs. no Testing in Asymptomatic High-risk Diabetic Patients

Conditions:   Asymptomatic;   High Risk;   Diabetes
Interventions:   Diagnostic Test: Echocardiography;   Diagnostic Test: CT angiography
Sponsor:   Clinical Centre of Serbia
Not yet recruiting

Quantification of Myocardial Blood Flow Using Dynamic PET/CTA Fused Imagery

Condition:   Coronary Artery Disease
Interventions:   Procedure: Invasive Cardiac Catheterization (ICA);   Procedure: Coronary Computed Tomographic Angiogram (CCTA);   Procedure: Dynamic Cardiac Positron Emission Tomography (dPET)
Sponsors:   Emory University;   Samsung Medical Center;   Seoul National University;   Chonnam National University Hospital;   National Heart, Lung, and Blood Institute (NHLBI)

Impact of a Digital Solution (CardiCare™) on Cardiorespiratory Fitness Improvement in Patients Discharged From a Phase 2 Cardiac Rehabilitation Following an Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Other: Wear an actigraph;   Other: Use the mobile application CardiCare™ and wear an actigraph
Sponsor:   Ad scientiam
Not yet recruiting

ACS Registry - A Non-interventional Study to Estimate the Rates of Outcomes in ACS Patients in Moscow

Conditions:   Heart Attack;   Stroke;   Cardiovascular Death
Sponsor:   AstraZeneca

New Time Clock for ST-elevation MI Based on Biochemical Myocardial Infarction Onset Time

Conditions:   Mi Q Wave;   Coronary Artery Disease
Intervention:   Diagnostic Test: Biochemical markers
Sponsor:   Tabba Heart Institute

The Value of CT-FFR Compared to CCTA or CCTA and Stress MPI in Low to Intermediate Risk ED Patients With Toshiba CT-FFR

Conditions:   Coronary Artery Disease;   Chest Pain;   Acute Coronary Syndrome;   Acute Myocardial Infarction
Intervention:   Device: Toshiba CT-FFR
Sponsors:   Northwell Health;   Toshiba America Medical Systems, Inc.
Enrolling by invitation

The Cardiovascular Multi-dimensional Observational Investigation of the Use of PCSK9 Inhibitors (cvMOBIUS)

Condition:   ASCVD
Sponsors:   Amgen;   Duke Clinical Research Institute

E. Coli Nissle 1917 - Suspension for Infection Prophylaxis

Condition:   Infections
Interventions:   Drug: EcN-Suspension;   Drug: Placebo
Sponsors:   Ardeypharm GmbH;   ICON plc
Active, not recruiting

Heart Failure and Preserved Ejection Fraction: Observation of Its Progression and Prognosis (HOPP-BERN)

Condition:   Heart Failure With Preserved Ejection Fraction
Sponsor:   University Hospital Inselspital, Berne

Safety and Effectiveness of the Orsiro Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions

Conditions:   Coronary Artery Disease;   Atherosclerosis, Coronary;   Myocardial Ischemia;   Ischemic Heart Disease;   Acute Coronary Syndrome;   Angina Pectoris
Intervention:   Device: Orsiro DES
Sponsor:   Biotronik, Inc.

Different Anti-Spastic Therapy Strategies After CABG Using Radial Artery Grafts

Conditions:   Coronary Artery Bypass Graft;   Radial Artery Grafts;   Antispastic Therapy;   Pilot Study
Interventions:   Drug: Nicorandil;   Drug: Diltiazem Hydrochloride;   Drug: Isosorbide Mononitrate 50 mg
Sponsors:   Ruijin Hospital;   Chugai Pharma China

A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Tirzepatide;   Drug: Dulaglutide
Sponsor:   Eli Lilly and Company
Not yet recruiting

Digital Cardiac Counseling Trial: DCC Trial

Conditions:   Cardiovascular Diseases;   Cardiovascular Risk Factor
Intervention:   Other: Digital cardiac Counseling
Sponsor:   Academisch Ziekenhuis Maastricht
Not yet recruiting

Effect of Efpeglenatide on Cardiovascular Outcomes

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Efpeglenatide (SAR439977);   Drug: Placebo
Sponsor:   Sanofi
Active, not recruiting

Cardiovascular Events in Chronic Obstructive Pulmonary Disease Patients Initiating Olodaterol or Other Long-acting beta2 Agonists

Condition:   Pulmonary Disease, Chronic Obstructive
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Angiography-Derived FFR And IVUS for Clinical Outcomes in Patients With Coronary Artery Disease

Condition:   Coronary Artery Disease
Interventions:   Procedure: Angiography-derived FFR;   Procedure: IVUS
Sponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Seoul National University Hospital;   Keimyung University Dongsan Medical Center;   First People's Hospital of Hangzhou;   Guangdong Provincial People's Hospital;   Peking University Third Hospital;   The Affiliated Hospital of Hangzhou Normal University;   Fujian Medical University Union Hospital;   RenJi Hospital;   Shanxi cardiovascular hospital;   Second Hospital of Shanxi Medical University;   First Affiliated Hospital of Wenzhou Medical University;   Second Affiliated Hospital of Wenzhou Medical University;   Wuhan University

Optimal Timing of Transcatheter Aortic Valve Implantation and Percutaneous Coronary Intervention - The TAVI PCI Trial

Conditions:   Aortic Stenosis;   Coronary Artery Disease;   TAVI;   PCI
Interventions:   Procedure: PCI before TAVI;   Procedure: PCI after TAVI
Sponsor:   University of Zurich
Not yet recruiting

"Post-acute Pickwick Study" (Postacute-Pick-2020)

Conditions:   Acute on Chronic Hypercapnic Respiratory Failure;   Obesity Hypoventilation Syndrome (OHS)
Interventions:   Procedure: "Lifestyle modifications" group (Control);   Procedure: Automatic NIV;   Procedure: CPAP treatment group;   Procedure: NIV treatment groups
Sponsor:   Juan F. Masa
Not yet recruiting

Rivaroxaban for the Prevention of Deep Vein Thrombosis in Patients With Left Iliac Vein Compression - The PLICTS Study

Condition:   May-Thurner Syndrome
Interventions:   Drug: Rivaroxaban;   Drug: Warfarin;   Drug: Nadroparin
Sponsors:   Second Affiliated Hospital, School of Medicine, Zhejiang University;   Sir Run Run Shaw Hospital;   Huadong Hospital;   Shanghai Zhongshan Hospital;   Shanghai 5th People's Hospital;   Yantai Yuhuangding Hospital;   Anhui Provincial Hospital

Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity

Conditions:   Overweight;   Obesity
Interventions:   Drug: Semaglutide;   Drug: Placebo (semaglutide)
Sponsor:   Novo Nordisk A/S

AVJ-514 Japan Trial

Conditions:   Mitral Stenosis With Insufficiency;   Functional Mitral Regurgitation;   Mitral Insufficiency;   Mitral Valve Incompetence;   Mitral Valve Regurgitation
Intervention:   Device: AVJ-514
Sponsor:   Abbott Medical Devices
Active, not recruiting

Acute Kidney Injury Genomics and Biomarkers in TAVR Study

Conditions:   Acute Kidney Injury;   Renal Insufficiency, Chronic;   Heart Failure;   Myocardial Infarction;   Arrhythmias, Cardiac;   Stroke
Intervention:   Procedure: Transcatheter Aortic Valve Replacement
Sponsor:   University of Texas Southwestern Medical Center
Active, not recruiting

An Efficacy, Safety and Tolerability Study of Ixmyelocel-T Administered Via Transendocardial Catheter-based Injections to Subjects With Heart Failure Due to Ischemic Dilated Cardiomyopathy (IDCM)

Condition:   Ischemic Dilated Cardiomyopathy (IDCM)
Interventions:   Biological: ixmyelocel-T;   Other: Placebo
Sponsor:   Vericel Corporation