Angina

Clinical Trial Finder

Many patients with angina are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Comparison of Anticoagulation for All-comers Undergoing Percutaneous Coronary Revascularization Trial

Condition:   Percutaneous Coronary Intervention
Interventions:   Drug: Bivalirudin;   Drug: Unfractionated heparin
Sponsor:   Kaiser Permanente
Recruiting - verified May 2015

High-Sensitivity Troponin T Plasma Levels in Patients With Aortic Stenosis (Tyrolean Aortic Stenosis Study-2)

Conditions:   Aortic Stenosis;   Heart Failure;   Syncope;   Angina Pectoris
Intervention:   Procedure: Aortic Valve Intervention (surgical or transcatheter)
Sponsor:   Medical University Innsbruck
Not yet recruiting - verified May 2015

Factors Associated With Perioperative Outcomes in Non-emergency Surgery

Conditions:   Stroke;   Acute Coronary Syndrome;   Pneumonia
Intervention:   Other: stroke or myocardial infarction or pneumonia
Sponsors:   University of Nottingham;   University of Wisconsin, Madison
Completed - verified May 2015

Natural History of Atherosclerosis in Real-World Patients Underwent Computed Tomography Angiography

Conditions:   Coronary Atherosclerosis;   Coronary Artery Disease;   Radiocontrast-induced Thyroid Dysfunction;   Contrast-induced Nephropathy
Interventions:   Radiation: Coronary computed tomography angiography;   Radiation: Quantitative coronary angiography
Sponsors:   Ural State Medical Academy;   Ural Institute of Cardiology;   De Haar Research Foundation
Enrolling by invitation - verified May 2015

The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome

Conditions:   Depression;   Acute Coronary Syndrome
Interventions:   Drug: Melatonin (N-acetyl-5-methoxytryptamine);   Drug: Placebo
Sponsors:   Roskilde County Hospital;   Psychiatric Research Unit, Region Zealand, Denmark;   University of Copenhagen;   Pharma Nord
Not yet recruiting - verified May 2015

Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis

Condition:   Asymptomatic Severe Aortic Stenosis
Intervention:   Procedure: surgical aortic valve replacement
Sponsor:   Clinical Centre of Serbia
Not yet recruiting - verified May 2015

Efficacy and Safety of BiomatrixTM Stent and 5mg-Maintenance Dose of Prasugrel in Patients With Acute Coronary Syndrome

Conditions:   Cardiac Death;   Hemorrhage;   Cerebrovascular Accident;   Myocardial Infarction
Interventions:   Device: BES (biodegradable polymer biolimus-eluting stent);   Drug: Prasugel;   Drug: Clopidogrel
Sponsor:   Chonnam National University Hospital
Recruiting - verified May 2015

The Use of Texting Messaging to Improve the Hospital-to-community Transition Period in Cardiovascular Disease Patients

Conditions:   Cardiovascular Disease;   Acute Coronary Syndrome
Intervention:   Behavioral: Txt2Prevent
Sponsors:   Simon Fraser University;   Providence Health & Services;   University of British Columbia;   McMaster University;   Canadian Institutes of Health Research  (CIHR)
Not yet recruiting - verified May 2015

Liraglutide to Improve corONary Haemodynamics During Exercise streSS

Conditions:   Ischaemic Heart Disease;   Coronary Heart Disease;   Chronic Stable Angina
Interventions:   Drug: Liraglutide;   Other: Placebo
Sponsors:   King's College London;   Guy's and St Thomas' NHS Foundation Trust
Completed - verified May 2015

A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Acetylsalicylic acid;   Drug: Rivaroxaban;   Drug: Clopidogrel;   Drug: Ticagrelor
Sponsors:   Janssen Research & Development, LLC;   Bayer;   Duke Clinical Research Institute;   Harvard Medical School
Recruiting - verified May 2015

Palliative Care for Patients With Advanced Heart Disease

Conditions:   Acute Coronary Syndrome;   Congestive Cardiac Failure;   Palliative Care
Intervention:   Other: Palliative Care Intervention
Sponsor:   University of Edinburgh
Recruiting - verified May 2015

RuSsian RegisTry of Acute CoronaRy SyndromE TreAtMent and Approach in Dual Antiplatelet Therapy

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified May 2015

Effect of GS-6615 on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy

Condition:   Hypertrophic Cardiomyopathy
Interventions:   Drug: GS-6615;   Drug: Placebo
Sponsor:   Gilead Sciences
Recruiting - verified May 2015

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified May 2015

Real Life Long-term Adherence to Ticagrelor After PCI for Acute Coronary Syndromes

Condition:   Acute Coronary Syndrome (ACS)
Intervention:   Drug: Ticagrelor
Sponsor:   IHF GmbH - Institut für Herzinfarktforschung
Active, not recruiting - verified May 2015

Rapid Assessment of Potential Ischaemic Heart Disease With CTCA

Condition:   Acute Coronary Syndrome
Intervention:   Radiation: CT Coronary Angiogram
Sponsors:   University of Edinburgh;   NHS Lothian
Recruiting - verified May 2015

Study Of Costs Realized After Percutaneous Coronary intervenTion Employing Same Day Discharge

Condition:   Coronary Artery Disease
Intervention:   Procedure: Same day discharge
Sponsors:   Saint Joseph Mercy Health System;   Michigan Heart;   Blue Cross Blue Shield of Michigan Foundation
Suspended - verified May 2015

Diuretic Comparison Project

Condition:   Hypertension
Interventions:   Drug: Hydrochlorothiazide;   Drug: Chlorthalidone
Sponsor:   Department of Veterans Affairs
Not yet recruiting - verified May 2015

Progression of Coronary Atherosclerosis in Asymptomatic Diabetic Subjects

Conditions:   Type 2 Diabetes;   Coronary Artery Disease
Intervention:  
Sponsors:   British Cardiac Research Trust;   Royal Free Hospital NHS Foundation Trust;   London North West Healthcare NHS Trust;   Barnet and Chase Farm Hospitals NHS Trust;   Diabetes and Obesity Research Network;   Lund University;   Health Diagnostic Laboratory, Inc.
Recruiting - verified May 2015

Observational Prospective Study OPTIMA II - Follow-up

Condition:   Major Adverse Cardiovascular and Cerebrovascular Events (MACCE)
Intervention:  
Sponsor:   AstraZeneca
Completed - verified May 2015

Cardiovascular Outcomes Following Treatment With Ertugliflozin in Participants With Type 2 Diabetes Mellitus and Established Vascular Disease (MK-8835-004)

Condition:   Type 2 Diabetes Mellitus
Interventions:   Drug: Ertugliflozin;   Drug: Placebo
Sponsors:   Merck Sharp & Dohme Corp.;   Pfizer
Recruiting - verified May 2015

The Evaluation of Bococizumab (PF-04950615; RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified May 2015

The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects

Condition:   Cardiovascular Disease
Interventions:   Drug: bococizumab (PF-04950615);   Drug: Placebo
Sponsor:   Pfizer
Recruiting - verified May 2015

Prevention of Cardiovascular Events by Antiplatelet Agents After Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified May 2015

Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)

Condition:   Diabetes Mellitus, Type 2
Interventions:   Drug: Placebo;   Drug: Linagliptin
Sponsors:   Boehringer Ingelheim;   Eli Lilly and Company
Recruiting - verified May 2015

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk

Condition:   Dyslipidemia
Interventions:   Biological: Evolocumab (AMG 145);   Other: Placebo;   Drug: Effective statin therapy
Sponsor:   Amgen
Recruiting - verified May 2015

Angina Prevalence and Provider Evaluation of Angina Relief

Condition:   Stable Coronary Artery Disease (CAD).
Intervention:  
Sponsors:   Saint Luke's Health System;   Gilead Sciences
Enrolling by invitation - verified May 2015

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab SAR236553 (REGN727)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab SAR236553 (REGN727);   Other: placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified May 2015

Phase III Trial of Dantonic® (T89) Capsule to Prevent and Treat Stable Angina

Condition:   Angina Pectoris
Interventions:   Drug: T89 high dose;   Drug: T89 Low dose;   Drug: Sanqi+Bingpian;   Drug: Placebo
Sponsor:   Tasly Pharmaceuticals, Inc.
Recruiting - verified May 2015

A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Brilinta

Condition:   Acute Coronary Syndromes
Intervention:  
Sponsor:   AstraZeneca
Recruiting - verified May 2015

Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.

Condition:   Smoking Cessation
Interventions:   Drug: placebo;   Drug: varenicline tartrate;   Drug: bupropion hydrochloride;   Drug: Nicotine Replacement Therapy Patch
Sponsor:   Pfizer
Active, not recruiting - verified May 2015

Natural History of Carotid Atherosclerosis

Conditions:   Carotid Artery Disease;   Stroke;   Myocardial Infarction;   Angina Pectoris
Intervention:  
Sponsor:   University of Athens
Recruiting - verified May 2015

Efficacy and Safety of Targeted Intramyocardial Delivery of Auto CD34+ Stem Cells for Improving Exercise Capacity in Subjects With Refractory Angina

Conditions:   Chronic Myocardial Ischemia;   Refractory Angina Pectoris;   (Advanced) Coronary Heart Disease
Interventions:   Biological: Auto-CD34+ cells;   Biological: Placebo: Diluent used to suspend Auto-CD34+ cells;   Other: Standard of care
Sponsor:   Baxter Healthcare Corporation
Active, not recruiting - verified May 2015

Cyclosporine and Prognosis in Acute Myocardial Infarction (MI) Patients

Condition:   ST Elevation Acute Myocardial Infarction
Interventions:   Drug: Injection of Cyclosporin;   Drug: Placebo;   Procedure: Echocardiography
Sponsor:   Hospices Civils de Lyon
Active, not recruiting - verified April 2015

Efficacy of LCQ908 on Cardiovascular Risk

Conditions:   Coronary Artery Disease;   Hypertriglyceridemia
Interventions:   Drug: LCQ908;   Drug: Placebo
Sponsor:   Novartis Pharmaceuticals
Terminated - verified May 2015

Allopurinol in Acute Coronary Syndrome

Condition:   Chronic Stable Angina
Interventions:   Drug: Allopurinol;   Drug: Allopurinol;   Drug: Placebo
Sponsors:   Stephen McSwiggan;   British Heart Foundation
Terminated - verified May 2015

Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)

Condition:   Atherosclerosis
Interventions:   Drug: Canakinumab;   Drug: Placebo
Sponsor:   Novartis Pharmaceuticals
Active, not recruiting - verified May 2015

International Survey of Acute Coronary Syndromes in Transitional Countries

Conditions:   Acute Coronary Syndrome;   Unstable Angina Pectoris;   Myocardial Infarction;   Coronary Disease
Intervention:  
Sponsor:   University of Bologna
Recruiting - verified May 2015

Registry of Acute Coronary Syndromes in the Lazio Region of Italy

Condition:   Acute Coronary Syndromes
Intervention:  
Sponsors:   San Filippo Neri General Hospital;   Associazione Nazionale Medici Cardiologi Ospedalieri
Recruiting - verified May 2015

PROspective Multicenter Imaging Study for Evaluation of Chest Pain

Condition:   Chest Pain
Interventions:   Device: Coronary Angiography;   Device: Stress Echocardiogram;   Device: Nuclear Stress Test;   Device: Exercise Electrocardiogram
Sponsors:   Duke University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified March 2015

FAME II - Fractional Flow Reserve (FFR) Guided Percutaneous Coronary Intervention (PCI) Plus Optimal Medical Treatment (OMT) Verses OMT

Condition:   Coronary Artery Disease
Interventions:   Other: Stenting plus OMT;   Other: Standard of care
Sponsor:   St. Jude Medical
Active, not recruiting - verified May 2015

Chronotherapy With Low-dose Aspirin for Primary Prevention

Condition:   Type 2 Diabetes
Interventions:   Drug: aspirin;   Drug: aspirin
Sponsor:   University of Vigo
Recruiting - verified May 2015

Improving Medication Adherence in Post-ACS Patients

Conditions:   Medication Adherence;   Acute Coronary Syndrome
Intervention:   Behavioral: PST therapy
Sponsors:   Columbia University;   National Heart, Lung, and Blood Institute (NHLBI)
Terminated - verified May 2015

A Study Evaluating the Efficacy and Safety of Abciximab, an Anti-Platelet Therapy, in Patients With Unstable Angina Not Responding to Standard Medical Therapy Who Are Eligible for Coronary Angioplasty

Conditions:   Angina, Unstable;   Angioplasty, Transluminal, Percutaneous Coronary
Interventions:   Drug: Abciximab;   Drug: Placebo
Sponsor:   Centocor, Inc.
Completed - verified May 2015

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