Acute Coronary Syndrome

Clinical Trial Finder

Many patients with acute coronary syndrome are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

BMX Alpha Registry: a Post-market Registry of the BioMatrix Alpha TM

Conditions:   Coronary Artery Disease;   Stable Angina;   Ischemia;   Acute Coronary Syndrome;   NSTEMI;   STEMI
Intervention:   Device: BioMatrix AlphaTM
Sponsors:   Biosensors Europe SA;   European Cardiovascular Research Center
Not yet recruiting - verified August 2016

OCT Based Edge and In-stent Vascular Response After Cordimax Stent in patIents With NSTE-ACS

Conditions:   Angina, Unstable;   Non-ST-Segment Elevation Myocardial Infarction
Interventions:   Device: OCT;   Device: eLuting stent
Sponsor:   Xijing Hospital
Not yet recruiting - verified May 2016

Instantaneous Wave-Free Ratio and Fractional Flow Reserve for the Assessment of Non Culprit Lesions in Patients With ST-segment Elevation Myocardial Infarction

Condition:   ST Segment Elevation Myocardial Infarction
Intervention:   Other: FFR and iFR
Sponsor:   Azienda Ospedaliera San Camillo Forlanini
Recruiting - verified August 2016

New Biomarkers in Heart- and Renal Failure

Conditions:   Heart Failure;   Kidney Failure
Sponsor:   RWTH Aachen University
Recruiting - verified July 2016

Extra Corporeal Membrane Oxygenation in the Acute Respiratory Distress Syndrome: Utility of a Biomarker to Assess the Membrane Efficiency in Improving Oxygenation

Condition:   Extra Corporel Membrane Oxygenation and Mciroparticles
Intervention:   Other: Blood draw
Sponsor:   Assistance Publique Hopitaux De Marseille
Active, not recruiting - verified August 2016

Which Platelet Function Test Best Reflects the In Vivo Plasma Concentrations of Ticagrelor and Its Active Metabolite?

Conditions:   Infarction;   Myocardial Infarction;   Cardiovascular Diseases;   Heart Diseases;   Ischemia;   Myocardial Ischemia;   Necrosis;   Pathologic Processes;   Vascular Diseases
Sponsor:   Collegium Medicum w Bydgoszczy
Completed - verified August 2016

A Prospective Pilot Study to Evaluate a New Marker of Ischemia in Chest Pain Triage

Condition:   Acute Coronary Syndrome
Intervention:   Other: blood samples
Sponsor:   Assistance Publique Hopitaux De Marseille
Recruiting - verified August 2016

"Me and My Heart" Study

Condition:   Acute Coronary Syndrome
Interventions:   Device: Active group with MEMS;   Device: Active group without MEMS;   Device: Control group with MEMS;   Device: Control group without MEMS
Sponsor:   AstraZeneca
Recruiting - verified August 2016

Aiming Towards Evidence Based Interpretation of Cardiac Biomarkers in Patients Presenting With Chest Pain

Condition:   Acute Coronary Syndrome
Sponsors:   Haukeland University Hospital;   Helse Stavanger HF
Recruiting - verified August 2016

Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome

Conditions:   Childhood Acute Myeloid Leukemia;   Childhood Myelodysplastic Syndrome;   Cytopenia;   Down Syndrome;   Myeloid Leukemia Associated With Down Syndrome;   Myeloproliferative Neoplasm
Interventions:   Drug: Asparaginase;   Drug: Asparaginase Erwinia chrysanthemi;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Etoposide;   Other: Laboratory Biomarker Analysis;   Drug: Mitoxantrone Hydrochloride;   Drug: Thioguanine
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Recruiting - verified August 2016

Increased Adsorption Membranes During Cardiopulmonary Bypass

Conditions:   Cardiopulmonary Bypass;   Acute Kidney Injury;   Systemic Inflammatory Response Sydrome
Intervention:   Device: OXIRIS®
Sponsor:   Hospital Universitari de Bellvitge
Recruiting - verified August 2016

A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart

Condition:   Acute Coronary Syndromes
Interventions:   Drug: Apixaban;   Drug: vitamin K antagonist;   Drug: Acetylsalicylic acid;   Other: Acetylsalicylic acid placebo
Sponsors:   Bristol-Myers Squibb;   Pfizer;   Duke Clinical Research Institute
Recruiting - verified August 2016

Affordability and Real-world Antiplatelet Treatment Effectiveness After Myocardial Infarction Study

Condition:   Cost Sharing, Acute Coronary Syndrome,
Intervention:   Other: Study voucher card
Sponsors:   AstraZeneca;   Duke Clinical Research Institute
Recruiting - verified August 2016

Platelet Reactivity Inhibition Following Ticagrelor Loading Dose and One Year Outcome

Condition:   Acute Coronary Syndrome
Intervention:   Other: blood sample
Sponsor:   Assistance Publique Hopitaux De Marseille
Recruiting - verified August 2016

A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Acetylsalicylic acid;   Drug: Rivaroxaban;   Drug: Clopidogrel;   Drug: Ticagrelor
Sponsors:   Janssen Research & Development, LLC;   Bayer;   Duke Clinical Research Institute;   Harvard Medical School
Recruiting - verified August 2016

Switching From Ticagrelor to Clopidogrel in Patients With Coronary Artery Disease

Condition:   Coronary Artery Disease
Interventions:   Drug: Clopidogrel;   Drug: Ticagrelor
Sponsor:   University of Florida
Recruiting - verified August 2016

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified August 2016

Magnetic Nanoparticles System in Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome
Sponsors:   Far Eastern Memorial Hospital;   National Taiwan University Hospital
Recruiting - verified August 2016

Comparison of MEOPA + Paracetamol Versus Morphine Treatment in Acute Coronary Syndrome Analgesia.

Condition:   Acute Coronary Syndrome
Interventions:   Drug: MEOPA and paracetamol;   Drug: Morphine
Sponsor:   University Hospital, Toulouse
Recruiting - verified August 2016

Integrating Depression Care in Acute Coronary Syndromes Care in China

Conditions:   Acute Coronary Syndromes;   Depression
Intervention:   Other: Integrated care model for ACS and depression
Sponsors:   The George Institute for Global Health, China;   National Institute of Mental Health (NIMH);   Peking University Sixth Hospital
Recruiting - verified August 2016

Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)

Conditions:   Atrial Fibrillation;   Percutaneous Coronary Intervention
Interventions:   Drug: Dabigatran Etexilate 110mg;   Drug: Warfarin 3mg;   Drug: Aspirin;   Drug: Dabigatran Etexilate 150mg;   Drug: Clopidogrel or Ticagrelor;   Drug: Clopidogrel or Ticagrelor;   Drug: Warfarin 5mg;   Drug: Clopidogrel or Ticagrelor;   Drug: Warfarin 1mg
Sponsor:   Boehringer Ingelheim
Recruiting - verified August 2016

Osteopathic Treatment and Deep Vein Thrombosis (DVT)

Condition:   Deep Vein Thrombosis (DVT)
Intervention:   Other: Osteopathic Treatment
Sponsor:   Nova Scotia Health Authority
Recruiting - verified August 2016

MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis

Conditions:   Mucopolysaccharidosis I;   Mucopolysaccharidosis II;   Mucopolysaccharidosis VI;   Mucopolysaccharidosis VII;   Hurler Syndrome;   Hunter Syndrome;   Maroteaux Lamy Syndrome;   Sly Syndrome;   Glycoprotein Metabolic Disorders;   Alpha Mannosidosis;   Fucosidosis;   Aspartylglucosaminuria;   Adrenoleukodystrophy;   Peroxisomal Disorders;   Osteopetrosis;   Sphingolipidosis;   Gangliosidosis;   Globoid Cell Leukodystrophy;   Metachromatic Leukodystrophy;   Niemann Pick B;   Niemann Pick C Subtype 2;   I-cell Disease
Interventions:   Procedure: blood stem cell transplant;   Drug: Rabbit Anti-Thymocyte Globulin (ATG);   Drug: Fludarabine;   Drug: Busulfan;   Drug: Cyclophosphamide;   Drug: Cyclosporine A (CSA);   Drug: Methylprednisolone;   Drug: Mycophenolate Mofetil (MMF);   Drug: Granulocyte-Colony Stimulating Factor (G-CSF);   Drug: Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF);   Drug: N-acetylcysteine;   Drug: Celecoxib;   Drug: Vitamin E;   Drug: Alpha Lipoic Acid
Sponsor:   Masonic Cancer Center, University of Minnesota
Recruiting - verified August 2016

Early Predictive Factors of Cardiac and Cerebral Involvement in TMA

Conditions:   Thrombotic Microangiopathy,;   Thrombotic Thrombocytopenic Purpura,
Intervention:   Other: Biological and imaging investigations
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting - verified August 2016

Vascular Inflammation Imaging Using Somatostatin Receptor Positron Emission Tomography

Conditions:   Atherosclerosis;   Stroke;   Transient Ischemic Attack;   Chronic Stable Angina;   Acute Coronary Syndrome
Sponsor:   University of Cambridge
Completed - verified August 2016

APRV/BIPAP With Spontaneous Breathing on Lung Protection

Conditions:   Respiratory Insufficiency;   Ventilator-Induced Lung Injury
Intervention:   Other: Pressure targeted modes
Sponsors:   St. Michael's Hospital, Toronto;   University of Toronto
Recruiting - verified August 2016

EPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures

Condition:   Acute Respiratory Distress Syndrome
Interventions:   Other: Esophageal-pressure guided mechanical ventilation;   Other: High PEEP mechanical ventilation
Sponsors:   Beth Israel Deaconess Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified August 2016

Non-Invasive Ventilation Preoperative Lung Resection Surgery

Condition:   Surgery for Primary Lung Cancer
Intervention:   Device: Manufacturer (VPAP ST)
Sponsors:   University Hospital, Brest;   Ministry of Health, France
Recruiting - verified August 2016

Hospital vs. Cell Phone Number Follow-Up Randomization Study

Condition:   Subject Follow-up
Interventions:   Other: Hospital Landline Phone Calls;   Other: Private Cell Phone Calls
Sponsor:   University of Pennsylvania
Completed - verified August 2016

Hybrid Effectiveness-Implementation Study to Improve Clopidogrel Adherence

Conditions:   Cardiovascular Disease;   Acute Coronary Syndrome
Intervention:   Other: Multifaceted Intervention with pharmacist and IVR
Sponsor:   VA Office of Research and Development
Recruiting - verified August 2016

Microcirculation In Acute Coronary Syndromes

Condition:   ST Elevation (STEMI) Myocardial Infarction
Interventions:   Drug: Rosuvastatin;   Drug: Simvastatin
Sponsors:   Helse Stavanger HF;   Helse Vest;   University Hospital of North Norway;   St. Olavs Hospital
Recruiting - verified August 2016

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia

Conditions:   B Acute Lymphoblastic Leukemia;   Bone Necrosis;   Central Nervous System Leukemia;   Cognitive Side Effects of Cancer Therapy;   Neurotoxicity Syndrome;   Pain;   Testicular Leukemia;   Therapy-Related Toxicity;   Untreated Adult Acute Lymphoblastic Leukemia;   Untreated Childhood Acute Lymphoblastic Leukemia
Interventions:   Drug: Clofarabine;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide;   Drug: Hydrocortisone Sodium Succinate;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Prednisone;   Radiation: Radiation Therapy;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Recruiting - verified August 2016

International Survey of Acute Coronary Syndromes in Transitional Countries

Conditions:   Acute Coronary Syndrome;   Unstable Angina Pectoris;   Myocardial Infarction;   Coronary Disease
Sponsor:   University of Bologna
Recruiting - verified August 2016

Database of Patients Undergoing Cardiac Computed Tomographic Angiography at William Beaumont Hospital (CT DATABASE)

Conditions:   Acute Coronary Syndrome;   Chest Pain
Sponsor:   Kavitha Chinnaiyan
Active, not recruiting - verified August 2016

Comparative Evaluation of Albumin and Starch Effects in Acute Lung Injury (ALI)

Conditions:   Lung Injury, Acute (ALI);   Respiratory Distress Syndrome, Acute (ARDS)
Interventions:   Drug: 5% human albumin;   Drug: 6% hetastarch
Sponsor:   Emory University
Terminated - verified August 2016

Acute Salt Handling in Orthostatic Intolerance

Conditions:   Postural Tachycardia Syndrome;   Orthostatic Tachycardia;   Orthostatic Intolerance
Intervention:   Other: normal saline (0.9%)
Sponsors:   Vanderbilt University;   National Center for Research Resources (NCRR);   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified August 2016

Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation Followed by Donor Bone Marrow Transplant, Mycophenolate Mofetil, and Cyclosporine in Treating Patients With Fanconi Anemia

Conditions:   Acute Myeloid Leukemia in Remission;   de Novo Myelodysplastic Syndrome;   Fanconi Anemia;   Previously Treated Myelodysplastic Syndrome
Interventions:   Procedure: Allogeneic Bone Marrow Transplantation;   Drug: Cyclophosphamide;   Drug: Cyclosporine;   Drug: Fludarabine Phosphate;   Other: Laboratory Biomarker Analysis;   Drug: Mycophenolate Mofetil;   Procedure: Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation;   Radiation: Total-Body Irradiation
Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI);   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified August 2016

Bone Marrow Transplant Studies for Safe and Effective Treatment of Leukemia

Conditions:   Graft vs Host Disease;   Hematologic Neoplasm;   Leukemia;   Multiple Myeloma;   Myelodysplastic Syndrome
Intervention:   Procedure: Allogeneic Bone Marrow Transplant
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified August 2016