Acute Coronary Syndrome

Clinical Trial Finder

Many patients with acute coronary syndrome are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called clinicaltrials.gov, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Physical Activity Intervention for Patients With Reduced Physical Performance After Acute Coronary Syndrome

Conditions:   Acute Coronary Syndrome;   Exercise-Related Amenorrhea
Interventions:   Other: physical activity intervention;   Other: standard of care
Sponsor:   University Hospital of Ferrara
Recruiting - verified January 2017

Chewing Ticagrelor Versus Prasugrel in ST-elevation Myocardial Infarction - A Platelet Reactivity Study

Conditions:   Acute Coronary Syndrome;   STEMI
Interventions:   Drug: Chewing Ticagrelor LD;   Drug: Chewing Prasugrel LD
Sponsor:   Sheba Medical Center
Not yet recruiting - verified January 2017

Mobile Health Strategies for Veterans

Condition:   Coronary Heart Disease
Interventions:   Behavioral: Text Message;   Behavioral: Mobile Application;   Other: Website
Sponsors:   University of California, San Francisco;   San Francisco Veterans Affairs Medical Center
Recruiting - verified January 2017

Safety and Tolerability of Sodium Thiosulfate in Patients With an ACS Undergoing PCI Via Radial Approach.

Condition:   Acute Coronary Syndrome
Intervention:   Drug: Sodium Thiosulfate Pentahydrate
Sponsor:   University Medical Center Groningen
Not yet recruiting - verified January 2017

Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease

Conditions:   Adverse Effect;   Atherosclerosis, Coronary;   Insulin Resistance Syndrome
Interventions:   Drug: Pioglitazone 15 mg Tablet;   Drug: Isosorbide Dinitrate 10Mg Tablet;   Drug: Acetylsalicylic Acid 75Mg Tablet;   Drug: Bisoprolol Fumarate 2.5 MG Oral Tablet;   Drug: Rosuvastatin Calcium 20 MG Oral Tablet;   Drug: ramipril 5 MG
Sponsor:   Ukrainian Medical Stomatological Academy
Completed - verified January 2017

Biomarker Effectiveness Analysis in Contrast Nephropathy (BEACON)

Conditions:   Acute Renal Failure;   Kidney Diseases;   Chronic Kidney Disease;   Coronary (Artery); Disease
Intervention:  
Sponsors:   University of Pittsburgh;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   U.S. Department of Veterans Affairs
Active, not recruiting - verified January 2017

LEADERS FREE II: BioFreedom™ Pivotal Study

Conditions:   Acute Coronary Syndrome;   High Bleeding Risk
Interventions:   Device: BioFreedom™ Drug Coated Coronary Stent System;   Drug: Dual Antiplatelet Therapy
Sponsor:   Biosensors Europe SA
Not yet recruiting - verified January 2017

In the Management of Coronary Artery Disease, Does Routine Pressure Wire Assessment - at the Time of Coronary Angiography - Affect Management Strategy, Hospital Costs and Outcomes?

Conditions:   Chest Pain;   Stable Angina;   Acute Coronary Syndrome;   Non ST Segment Elevation Acute Coronary Syndrome
Intervention:   Device: Routine Measurement of FFR
Sponsors:   University Hospital Southampton NHS Foundation Trust;   Liverpool Heart and Chest Hospital NHS Foundation Trust
Recruiting - verified January 2017

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations

Conditions:   B Acute Lymphoblastic Leukemia;   Bone Necrosis;   Central Nervous System Leukemia;   Cognitive Side Effects of Cancer Therapy;   Neurotoxicity Syndrome;   Pain;   Testicular Leukemia;   Therapy-Related Toxicity;   Untreated Adult Acute Lymphoblastic Leukemia;   Untreated Childhood Acute Lymphoblastic Leukemia
Interventions:   Drug: Clofarabine;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dasatinib;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide;   Drug: Hydrocortisone Sodium Succinate;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Prednisone;   Radiation: Radiation Therapy;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified December 2016

Cardiopulmonary Effects of Bronchoalveolar Wash on Patients With Acute Respiratory Distress Syndrome

Condition:   Bronchioalveolar Lavage
Intervention:   Procedure: Bronchoalveolar Lavage
Sponsor:   University Hospital, Limoges
Recruiting - verified January 2017

Chewing Versus Traditional Oral Administration of Ticagrelor in STEMI Patients

Conditions:   Acute Coronary Syndromes;   ST Elevation Myocardial Infarction
Interventions:   Drug: Chewing Ticagrelor;   Drug: Oral Ticagrelor
Sponsor:   Sheba Medical Center
Completed - verified January 2017

PARA-HEART Pilot Implementation

Conditions:   Acute Coronary Syndrome;   Chest Pain
Intervention:  
Sponsor:   Wake Forest University Health Sciences
Recruiting - verified January 2017

The National Myelodysplastic Syndromes (MDS) Study

Condition:   Myelodysplastic Syndromes (MDS)
Intervention:   Other: Therapeutic
Sponsors:   National Heart, Lung, and Blood Institute (NHLBI);   National Cancer Institute (NCI)
Recruiting - verified December 2016

Prophylactic Non-invasive Ventilation During Surgical Procedure in Rhythmology

Conditions:   Cardiac Electrophysiology;   Anesthesia;   Acute Respiratory Failure
Interventions:   Other: non invasive ventilation;   Other: Standard oxygen therapy with facial mask
Sponsor:   University Hospital, Grenoble
Recruiting - verified January 2017

Clinical Performance Evaluation of AQT90 FLEX TnI and TnT

Condition:   Myocardial Infarction
Intervention:  
Sponsor:   Radiometer Medical ApS
Recruiting - verified January 2017

Aspirin Twice a Day in Patients With Diabetes and Acute Coronary Syndrome

Conditions:   Diabetes Mellitus;   Acute Coronary Syndrome;   Coronary Artery Disease
Interventions:   Drug: Novel strategy Aspirin;   Drug: Conventional strategy Aspirin
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Bayer
Recruiting - verified January 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsor:   Bayer
Recruiting - verified January 2017

The Role of Sleep Disordered Breathing in Heart Failure Admissions

Conditions:   Sleep Apnea Syndromes;   Heart Failure
Intervention:   Device: Adaptive Servo Ventilation
Sponsors:   Rami Khayat;   Philips Respironics
Terminated - verified January 2017

A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart

Condition:   Acute Coronary Syndromes
Interventions:   Drug: Apixaban;   Drug: vitamin K antagonist;   Drug: Acetylsalicylic acid;   Other: Acetylsalicylic acid placebo
Sponsors:   Bristol-Myers Squibb;   Pfizer;   Duke Clinical Research Institute
Recruiting - verified August 2016

Affordability and Real-world Antiplatelet Treatment Effectiveness After Myocardial Infarction Study

Condition:   Cost Sharing, Acute Coronary Syndrome
Intervention:   Other: Study voucher card
Sponsors:   AstraZeneca;   Duke Clinical Research Institute
Active, not recruiting - verified January 2017

Frailty in Elderly Patients Receiving Cardiac Interventional Procedures

Condition:   Aged
Intervention:   Other: frailty evaluation
Sponsor:   University Hospital of Ferrara
Active, not recruiting - verified January 2017

Trans-pulmonary Pressure in ARDS

Condition:   Acute Respiratory Distress Syndrome
Interventions:   Device: level of positive end expiratory pressure (Prone Proseva);   Device: level of positive end expiratory pressure (Prone Talmor)
Sponsor:   Hospices Civils de Lyon
Recruiting - verified January 2017

Multi-cap for Increase Adherence After Acute Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Other: Combined capsule;   Other: Conventional therapy
Sponsor:   Hospital El Cruce
Terminated - verified January 2017

Is Efficacy of PLAtelet Aggregation Inhibition by Ticagrelor Mediated P2Y12 Blockade Dependent Upon Endogenous Endothelial Nitric OXide?

Condition:   Acute Coronary Syndome
Interventions:   Other: Blood Test;   Other: EndoPAT - endothelial assessment
Sponsor:   Jennifer Rossington
Completed - verified January 2017

Evaluation of iFR vs FFR in Stable Angina or Acute Coronary Syndrome

Conditions:   Angina Pectoris;   Acute Myocardial Infarction
Interventions:   Device: iFR;   Device: FFR
Sponsor:   Uppsala University
Completed - verified January 2017

Rivaroxaban for the Prevention of Venous Thromboembolism in Asian Patients With Cancer

Conditions:   Rivaroxaban;   Cancer-associated Thrombosis;   Recurrence;   Bleeding
Intervention:   Drug: Rivaroxaban
Sponsors:   Seoul National University Hospital;   Korean Society of Hematology Thrombosis Working Party
Completed - verified January 2017

Post Acute Coronary Event Smoking Study

Conditions:   Smoking Cessation;   Acute Coronary Syndrome
Interventions:   Behavioral: Behavioral Activation (BA);   Behavioral: Standard Smoking Cessation Counseling;   Drug: Nicotine patch;   Other: Printed Self-help materials for Smoking Cessation
Sponsor:   The Miriam Hospital
Completed - verified January 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Germany)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsor:   Bayer
Recruiting - verified January 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands)

Conditions:   Venous Thrombosis;   Pulmonary Embolism;   Atrial Fibrillation;   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxoban (Xarelto, Bay59-7939);   Drug: Standard of care
Sponsor:   Bayer
Recruiting - verified January 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)

Condition:   Pulmonary Embolism
Interventions:   Drug: Rivaroxaban (Xarelto, Bay59-7939);   Drug: Warfarin
Sponsor:   Bayer
Recruiting - verified January 2017

Optical Frequency Domain Imaging (OFDI) and Vascular Healing After Stent Placement Diabetics Presenting With Acute Coronary Syndrome

Condition:   Coronary Artery Disease
Intervention:   Device: Resolute Integrity stent
Sponsor:   Emory University
Completed - verified January 2017

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab

Condition:   Acute Coronary Syndrome
Interventions:   Drug: alirocumab;   Drug: Placebo
Sponsors:   Sanofi;   Regeneron Pharmaceuticals
Recruiting - verified January 2017

EPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures

Condition:   Acute Respiratory Distress Syndrome
Interventions:   Other: Esophageal-pressure guided mechanical ventilation;   Other: High PEEP mechanical ventilation
Sponsors:   Beth Israel Deaconess Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified January 2017

Non-Invasive Ventilation Preoperative Lung Resection Surgery

Condition:   Surgery for Primary Lung Cancer
Intervention:   Device: Manufacturer (VPAP ST)
Sponsors:   University Hospital, Brest;   Ministry of Health, France
Recruiting - verified January 2017

Tailored Antiplatelet Therapy Versus Recommended Dose of Prasugrel

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Modification of Prasugrel based on a biological assay;   Drug: prasugrel / clopidogrel;   Device: Verify Now
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Eli Lilly and Company;   Daiichi Sankyo Inc.;   Allies in Cardiovascular Trials Initiatives and Organized;   Accumetrics, Inc.;   Stentys
Completed - verified January 2017

Improving Blood Stem Cell Collection and Transplant Procedures

Conditions:   Myelodysplastic Syndrome (MDS);   Chronic Myelogenous Leukemia;   Acute Lymphoblastic Leukemia;   CML (Chronic Myelogenous Leukemia;   CLL (Chronic Lymphocytic Leukemia)
Intervention:   Procedure: Stem Cell Transplantation
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified April 2016

Drug-Eluting Stents vs. Bare Metal Stents In Saphenous Vein Graft Angioplasty

Condition:   Saphenous Vein Graft Atherosclerosis
Interventions:   Device: Bare Metal Stent;   Device: Drug-Eluting Stent;   Drug: Blinded clopidogrel;   Drug: Placebo;   Drug: Thienopyridine (open-label)
Sponsor:   VA Office of Research and Development
Completed - verified January 2017

Acarbose Cardiovascular Evaluation Trial

Conditions:   Coronary Heart Disease;   Acute Coronary Syndrome;   Impaired Glucose Tolerance;   Type 2 Diabetes Mellitus (T2DM)
Interventions:   Drug: Acarbose;   Drug: Matching Placebo
Sponsors:   University of Oxford;   Bayer
Active, not recruiting - verified January 2017

Effects of Intracoronary Progenitor Cell Therapy on Coronary Flow Reserve After Acute MI

Conditions:   Coronary Artery Disease;   Acute Myocardial Infarction
Interventions:   Biological: autologous bone marrow-derived progenitor cells;   Biological: placebo medium
Sponsors:   Johann Wolfgang Goethe University Hospital;   University of Leipzig
Terminated - verified January 2017

The Prevalence of Sleep Disordered Breathing in Hospitalized Patients With Acutely Decompensated Heart Failure Syndrome

Conditions:   Sleep Apnea;   Congestive Heart Failure;   Heart Failure
Intervention:  
Sponsor:   Ohio State University
Completed - verified January 2017

The Role of Sleep Apnea in the Acute Exacerbation of Heart Failure

Conditions:   Heart Failure;   Obstructive Sleep Apnea;   Heart Failure, Congestive
Intervention:   Device: CPAP Therapy
Sponsor:   Ohio State University
Active, not recruiting - verified January 2017

A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease

Condition:   Moderate Risk of CVD
Interventions:   Drug: Aspirin (Acetylsalicylic acid, BAYE4465);   Drug: Placebo
Sponsor:   Bayer
Completed - verified January 2017