Acute Coronary Syndrome

Clinical Trial Finder

Many patients with acute coronary syndrome are interested in participating in the latest research regarding their condition. This Clinical Trial Finder can help you—or a loved one—easily find ongoing cardiovascular clinical research trials for which you might qualify. This list is a service of the U.S. National Institutes of Health called, a database of publicly and privately supported clinical studies.

Simply click on the trial below that interests you to learn how you might participate.

Familial Investigations of Childhood Cancer Predisposition

Conditions:   Acute Leukemia;   Adenomatous Polyposis;   Adrenocortical Carcinoma;   AML;   BAP1 Tumor Predisposition Syndrome;   Carney Complex;   Choroid Plexus Carcinoma;   Constitutional Mismatch Repair Deficiency Syndrome;   Diamond-Blackfan Anemia;   DICER1 Syndrome;   Dyskeratosis Congenita;   Emberger Syndrome;   Familial Acute Myeloid Leukaemia;   Familial Adenomatous Polyposis;   Fanconi Anemia;   Familial Cancer;   Familial Wilms Tumor;   Familial Neuroblastoma;   GIST;   Hereditary Breast and Ovarian Cancer;   Hereditary Paraganglioma-Pheochromocytoma Syndrome;   Hodgkin Lymphoma;   Juvenile Polyposis;   Li-Fraumeni Syndrome;   Lynch Syndrome;   MDS;   Melanoma Syndrome;   Multiple Endocrine Neoplasia Type 1;   Multiple Endocrine Neoplasia Type 2;   Neuroblastoma;   Neurofibromatosis Type 1;   Neurofibromatosis Type II;   Nevoid Basal Cell Carcinoma Syndrome;   Non Hodgkin Lymphoma;   Noonan Syndrome and Other Rasopathy;   Overgrowth Syndromes;   Pancreatic Cancer;   Peutz-Jeghers Syndrome;   Pheochromocytoma/Paraganglioma;   PTEN Hamartoma Tumor Syndrome;   Retinoblastoma;   Rhabdoid Tumor Predisposition Syndrome;   Rhabdomyosarcoma;   Rothmund-Thomson Syndrome;   Tuberous Sclerosis;   Von Hippel-Lindau Disease
Sponsor:   St. Jude Children's Research Hospital
Recruiting - verified February 2017

PRESSUREwire Study

Conditions:   Coronary Artery Disease;   Acute Coronary Syndrome
Intervention:   Device: Fractional Flow Reserve
Sponsor:   St. Jude Medical
Recruiting - verified March 2017

Prognostic Assessment of Diastolic and Systolic Left Ventricular Function in Septic Shock

Conditions:   Septic Shock;   Echocardiography;   Diastolic Dysfunction;   Hyperkinesia
Sponsors:   University Hospital, Limoges;   CIC 1415 INSERM - Tours University Hospital
Recruiting - verified March 2017

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations

Conditions:   B Acute Lymphoblastic Leukemia;   Bone Necrosis;   Central Nervous System Leukemia;   Cognitive Side Effects of Cancer Therapy;   Neurotoxicity Syndrome;   Pain;   Testicular Leukemia;   Therapy-Related Toxicity;   Untreated Adult Acute Lymphoblastic Leukemia;   Untreated Childhood Acute Lymphoblastic Leukemia
Interventions:   Drug: Clofarabine;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dasatinib;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide;   Drug: Hydrocortisone Sodium Succinate;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Prednisone;   Radiation: Radiation Therapy;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified December 2016

Increasing Exercise and Decreasing Sedentary Behavior Among Patients in a Cardiac Rehabilitation Clinic

Conditions:   Acute Coronary Syndrome;   Heart Failure;   Other Cardiac Conditions Among Cardiac Rehabilitation Participants
Interventions:   Other: B-MOBILE-CARDIAC smartphone application;   Behavioral: Cardiac rehabilitation as usual
Sponsor:   The Miriam Hospital
Enrolling by invitation - verified March 2017

The Effect of Ticagrelor on 15-Epi-Lipoxin A4 and Inflammation

Condition:   Atherosclerosis
Interventions:   Drug: Clopidogrel;   Drug: Ticagrelor
Sponsor:   Baylor College of Medicine
Recruiting - verified March 2017

"Me and My Heart" Study

Condition:   Acute Coronary Syndrome
Interventions:   Device: Active group with MEMS;   Device: Active group without MEMS;   Device: Control group with MEMS;   Device: Control group without MEMS
Sponsor:   AstraZeneca
Recruiting - verified March 2017

SNPs in the DNase 1 Gene Impair Its Activity and Are Increased in a STE-ACS Patient Cohort Compared to Healthy Controls

Condition:   ST Elevation Myocardial Infarction
Intervention:   Other: Blood draw
Sponsor:   Medical University of Vienna
Enrolling by invitation - verified March 2017

Special Drug Use Investigation of Xarelto for Venous Thromboembolism (VTE)

Condition:   Venous Thromboembolism
Intervention:   Drug: Rivaroxaban (Xarelto, BAY59-7939)
Sponsors:   Bayer;   Janssen Research & Development, LLC
Recruiting - verified March 2017

Platelet Reactivity in Acute Non-disabling Cerebrovascular Events

Conditions:   Stroke;   Ischemic Attack, Transient
Interventions:   Drug: Ticagrelor and Acetylsalicylic acid;   Drug: Clopidogrel and Acetylsalicylic acid
Sponsors:   Ministry of Science and Technology of the People´s Republic of China;   Beijing Municipal Science & Technology Commission
Recruiting - verified March 2017

Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Sweden)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Rivaroxaban (Xarelto, BAY59-7939);   Drug: Standard of care drugs
Sponsors:   Bayer;   Janssen Scientific Affairs, LLC
Recruiting - verified March 2017

Increased Adsorption Membranes During Cardiopulmonary Bypass

Conditions:   Cardiopulmonary Bypass;   Acute Kidney Injury;   Systemic Inflammatory Response Syndrome
Intervention:   Device: OXIRIS®
Sponsors:   Hospital Universitari de Bellvitge;   Germans Trias i Pujol Hospital;   Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau;   Baxter Healthcare Corporation
Recruiting - verified March 2017

Absorb BVS vs. Drug Coated Balloon for Treatment Of ISR

Conditions:   Coronary Artery Disease;   Coronary Restenosis
Interventions:   Device: BVS Absorb implantation.;   Device: DEB Sequent Please inflation.;   Procedure: Control coronary angiography.;   Procedure: OCT visualization.;   Other: Clinical observation.
Sponsor:   SIS Medical AG
Recruiting - verified March 2017

An Observational Prospective Study to Understand the Usage Pattern of Ticagrelor With ACS (Acute Coronary Syndrome)

Condition:   Acute Coronary Syndrome
Sponsor:   AstraZeneca
Active, not recruiting - verified March 2017

Prospective Registry of Acute Heart Failure

Condition:   Acute Heart Failure
Intervention:   Procedure: blood sample
Sponsor:   Sebastian Carballo
Recruiting - verified March 2017

Plaque Regression and Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen (PREMIER), Phase II

Condition:   Acute Coronary Artery Syndrome
Interventions:   Procedure: Percutaneous coronary intervention;   Procedure: Intravascular ultrasound with virtual histology;   Drug: Atorvastatin or other equivalent dose statin;   Device: LDL-apheresis
Sponsor:   VA Office of Research and Development
Recruiting - verified March 2017

Switching From Ticagrelor to Clopidogrel in Patients With Coronary Artery Disease

Condition:   Coronary Artery Disease
Interventions:   Drug: Clopidogrel;   Drug: Ticagrelor
Sponsor:   University of Florida
Recruiting - verified March 2017

Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry

Condition:   Acute Coronary Syndromes
Intervention:   Other: Non-Interventional Study
Sponsor:   AstraZeneca
Recruiting - verified March 2017

Effect Of Early C-PAP Treatment For Sleep Apnea On Rehabilitation Of Stroke Patients

Conditions:   Sleep Apnea;   Stroke
Interventions:   Device: Watchpat;   Device: CPAP
Sponsor:   Soroka University Medical Center
Not yet recruiting - verified March 2017

Focus On Stiffness Reduction, Endothelial Function and Autonomic Nervous System

Conditions:   Arterial Stiffness;   Endothelial Function;   Autonomic Nervous System;   Acute Coronary Syndrome;   Arterial Hypertension
Intervention:   Other: comprehensive cardiac rehabilitation
Sponsor:   Medical Universtity of Lodz
Completed - verified March 2017

Phase I/II Trial of Early Infusion of Rapidly-generated Multivirus Specific T Cells (MVST) to Prevent Post Transplant Viral Infections

Conditions:   Chronic Lymphocytic Leukemia;   CML (Chronic Myelogenous Leukemia);   MDS (Myelodysplastic Syndrome);   Acute Lymphoblastic Leukemia;   AML (Acute Myelogenous Leukemia)
Interventions:   Biological: MVST;   Biological: MVSTr
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 15, 2017

A Phase 3 Clinical Outcomes Study to Compare the Incidence of Major Adverse Cardiovascular Events in Subjects Presenting With Acute Coronary Syndrome Treated With Losmapimod Compared to Placebo (LATITUDE-TIMI 60)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Losmapimod 7.5 mg twice daily;   Drug: Placebo twice daily;   Drug: Standard therapy
Sponsors:   GlaxoSmithKline;   The TIMI Study Group
Completed - verified March 2017

MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis

Conditions:   Mucopolysaccharidosis Disorders;   Hurler Syndrome;   Hunter Syndrome;   Maroteaux Lamy Syndrome;   Sly Syndrome;   Alpha-Mannosidosis;   Fucosidosis;   Aspartylglucosaminuria;   Glycoprotein Metabolic Disorders;   Sphingolipidoses;   Recessive Leukodystrophies;   Globoid Cell Leukodystrophy;   Metachromatic Leukodystrophy;   Niemann-Pick B;   Niemann-Pick C Subtype 2;   Sphingomyelin Deficiency;   Peroxisomal Disorders;   Adrenoleukodystrophy With Cerebral Involvement;   Zellweger Syndrome;   Neonatal Adrenoleukodystrophy;   Infantile Refsum Disease;   Acyl-CoA Oxidase Deficiency;   D-Bifunctional Enzyme Deficiency;   Multifunctional Enzyme Deficiency;   Alpha-methylacyl-CoA Racmase Deficiency;   Mitochondrial Neurogastrointestingal Encephalopathy;   Severe Osteopetrosis;   Hereditary Leukoencephalopathy;   Inherited Metabolic Disorders
Interventions:   Biological: Stem Cell Transplantation;   Drug: IMD Preparative Regimen;   Drug: Osteopetrosis Only Preparative Regimen;   Drug: Osteopetrosis Haploidentical Only Preparative Regimen;   Drug: cALD SR-A (Standard-Risk, Regimen A);   Drug: cALD SR-B (Standard-Risk, Regimen B);   Drug: cALD HR-D (High-Risk, Regimen C);   Drug: cALD HR-D (High-Risk, Regimen D)
Sponsor:   Masonic Cancer Center, University of Minnesota
Recruiting - verified March 2017

Efficacy Evaluation of the HEART Pathway in Emergency Department Patients With Acute Chest Pain

Conditions:   Acute Coronary Syndrome;   Chest Pain
Intervention:   Other: HEART Pathway
Sponsors:   Wake Forest University Health Sciences;   American Heart Association
Active, not recruiting - verified February 2017

Donor Umbilical Cord Blood Transplant With or Without Ex-vivo Expanded Cord Blood Progenitor Cells in Treating Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, or Myelodysplastic Syndromes

Conditions:   Acute Biphenotypic Leukemia;   Acute Erythroid Leukemia;   Acute Lymphoblastic Leukemia in Remission;   Acute Megakaryoblastic Leukemia;   Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome;   Acute Myeloid Leukemia in Remission;   Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Mixed Phenotype Acute Leukemia;   Myelodysplastic Syndrome;   Myelodysplastic Syndrome With Excess Blasts;   Pancytopenia;   Refractory Anemia;   Secondary Acute Myeloid Leukemia
Interventions:   Drug: Cyclophosphamide;   Drug: Cyclosporine;   Procedure: Double-Unit Umbilical Cord Blood Transplantation;   Procedure: Ex Vivo-Expanded Cord Blood Progenitor Cell Infusion;   Drug: Fludarabine Phosphate;   Other: Laboratory Biomarker Analysis;   Drug: Mycophenolate Mofetil;   Radiation: Total-Body Irradiation;   Procedure: Umbilical Cord Blood Transplantation
Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2017

Intensive Blood Pressure and LDL Lowering in Diabetic Patients With Coronary Artery Disease

Conditions:   Type 2 Diabetes;   Coronary Artery Disease;   Hypertension;   Dyslipidemia
Interventions:   Other: intensive control;   Other: standard control
Sponsors:   Takeshi Morimoto;   University of the Ryukyus
Recruiting - verified March 2017

Evaluation of Routine Follow-up Coronary Angiography After Percutaneous Coronary Intervention Trial

Condition:   Coronary Artery Disease
Interventions:   Procedure: follow-up coronary angiography;   Procedure: Clinical follow-up
Sponsor:   Takeshi Morimoto
Completed - verified March 2017

The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial

Condition:   Acute Coronary Syndrome
Interventions:   Drug: Darapladib 160 mg;   Drug: Placebo;   Other: Standard Therapy
Sponsors:   GlaxoSmithKline;   The TIMI Study Group
Completed - verified March 2017

The Effects of Lowering Low-density Lipoprotein Cholesterol Levels to New Targets on Cardiovascular Complications in Peritoneal Dialysis Patients

Condition:   Hypercholesterolemia
Intervention:   Other: LDL-cholesterol
Sponsors:   Clinical Research Center for End Stage Renal Disease, Korea;   Ministry of Health & Welfare, Korea
Completed - verified October 2009

Fondaparinux Trial With Unfractionated Heparin (UFH) During Revascularization in Acute Coronary Syndromes (ACS)

Condition:   Acute Coronary Syndrome
Interventions:   Drug: fondaparinux background and standard dose UFH;   Drug: Fondaparinux background and low dose heparin;   Drug: Open label fondaparinux
Sponsor:   GlaxoSmithKline
Completed - verified March 2017

Evaluation of the Duration of Therapy for Thrombosis in Children

Condition:   Venous Thrombosis
Interventions:   Other: Shortened duration (6 weeks) of anticoagulant therapy;   Other: Conventional duration (3 months) of anticoagulant therapy;   Other: No Intervention;   Other: No Intervention
Sponsors:   Johns Hopkins All Children's Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2017

Acute Salt Handling in Orthostatic Intolerance

Conditions:   Postural Tachycardia Syndrome;   Orthostatic Tachycardia;   Orthostatic Intolerance
Intervention:   Other: normal saline (0.9%)
Sponsors:   Vanderbilt University;   National Center for Research Resources (NCRR);   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified March 2017

Effect of Low Tidal Volume Ventilation in Improving Oxygenation and Thus Reducing Acute Lung Injury in the Cardiac Surgical Patient

Condition:   Acute Respiratory Distress Syndrome
Intervention:   Other: Ventilation strategy
Sponsor:   Beth Israel Deaconess Medical Center
Completed - verified March 2017