rilpivirine

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rilpivirine

Pronunciation:RIL pi VIR een
Brand:Edurant

What is the most important information I should know about rilpivirine?

donotThe following drugs should not be used while you are taking rilpivirine: carbamazepine (Carbatrol, Equetro, Tegretol, Teril, Epitol), oxcarbazepine (Trileptal), phenobarbital (Solfoton, Luminal), phenytoin (Dilantin, Phenytek), rifabutin (Mycobutin), rifampin (Rifater, Rifadin, Rifamate, Rimactane), rifapentine (Priftin), esomeprazole (Nexium, Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), rabeprazole (Aciphex), St John's wort, delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), etravirine (Intelence), nevirapine (Viramune), or more than one dose of dexamethasone (Cortastat, Dexasone, Solurex, DexPak).
emtUsing any of these medicines while you are taking rilpivirine can cause serious medical problems or death.

Many other medicines can interact with rilpivirine, or make it less effective. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Before you take rilpivirine, tell your doctor if you have liver disease (including hepatitis B or C), kidney disease, a history of depression or mental illness, or if you have ever taken any HIV medication in the past.

donotDo not take rilpivirine as your only HIV medication. HIV/AIDS is usually treated with a combination of different drugs. Your disease may become resistant to rilpivirine if you do not take it in combination with other HIV medicines your doctor has prescribed.
emtCall your doctor at once if you have mood changes, anxiety, severe depression, feeling hopeless, or thoughts about suicide or hurting yourself.

Taking this medication will not prevent you from passing HIV to other people.

What is rilpivirine?

Rilpivirine is an antiviral medication that prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

Rilpivirine is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). Rilpivirine is not a cure for HIV or AIDS.

donotDo not take rilpivirine as your only HIV medication. Rilpivirine must be used in combination with other HIV medicines that your doctor has prescribed.

Rilpivirine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking rilpivirine?

donotYou should not use rilpivirine if you are allergic to it.
emtMany other drugs can cause serious or life threatening medical problems if you take them together with rilpivirine. The following drugs should not be used while you are taking rilpivirine:
  • carbamazepine (Carbatrol, Equetro, Tegretol, Teril, Epitol), oxcarbazepine (Trileptal), phenobarbital (Solfoton, Luminal), phenytoin (Dilantin, Phenytek);
  • rifabutin (Mycobutin), rifampin (Rifater, Rifadin, Rifamate, Rimactane), rifapentine (Priftin);
  • esomeprazole (Nexium, Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), rabeprazole (Aciphex);
  • more than one dose of dexamethasone (Cortastat, Dexasone, Solurex, DexPak);
  • St John's wort; or
  • delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), etravirine (Intelence), or nevirapine (Viramune).

To make sure you can safely take rilpivirine, tell your doctor if you have any of these other conditions:

  • liver disease (including hepatitis B or C);
  • kidney disease;
  • a history of depression or mental illness; or
  • if you have ever taken any HIV medication in the past.

FDA pregnancy category B. Rilpivirine is not expected to harm an unborn baby, but HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of rilpivirine on the baby.

nobrfeedWomen with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

How should I take rilpivirine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

foodRilpivirine is usually taken once per day with a meal. Always take the medicine with food.

Use rilpivirine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

emtTo be sure this medicine is helping your condition and is not causing harmful effects, your blood will need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly.

HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

rtStore at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

If you are less than 12 hours late in taking your medicine, take the missed dose with food as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

emtSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking rilpivirine?

If you also take an antacid, take it at least 2 hours before or 4 hours after taking rilpivirine. Do not take an antacid and rilpivirine at the same time.

If you also take didanosine (Videex), take it at least 2 hours before or 4 hours after taking rilpivirine.

If you also take a stomach acid reducer, take it at least 12 hours before or 4 hours after taking rilpivirine. This includes cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), and ranitidine (Zantac). Do not take rilpivirine and this type of stomach medicine at the same time.

donotTaking this medication will not prevent you from passing HIV to other people. Avoid having unprotected sex or sharing razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What are the possible side effects of rilpivirine?

emtGet emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
donotCall your doctor at once if you have any of these serious side effects:
  • mood changes, anxiety, severe depression, feeling hopeless, thoughts about suicide or hurting yourself;
  • fever, chills, cough with yellow or green mucus;
  • stabbing chest pain, wheezing, feeling short of breath; or
  • severe pain in your upper stomach spreading to your shoulder or back, stomach bloating, nausea and vomiting, sweating, fever, chills, loss of appetite.

Less serious side effects may include:

  • sleep problems (insomnia), unusual dreams;
  • mild nausea, vomiting, stomach pain, diarrhea;
  • headache, dizziness;
  • mild skin rash;
  • tired feeling; or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect rilpivirine?

Tell your doctor about all other medicines you use, especially:

  • arsenic trioxide (Trisenox);
  • bosentan (Tracleer);
  • conivaptan (Vaprisol);
  • imatinib (Gleevec);
  • isoniazid (for treating tuberculosis);
  • tacrolimus (Prograf);
  • an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), levofloxacin (Levaquin), moxifloxacin (Avelox), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), rifapentine (Priftin), pentamidine (NebuPent, Pentam), or telithromycin (Ketek);
  • an antidepressant such as amitriptylline (Elavil, Vanatrip, Limbitrol), clomipramine (Anafranil), desipramine (Norpramin), or nefazodone;
  • anti-malaria medications such as chloroquine (Aralen) or mefloquine (Lariam);
  • antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), or voriconazole (Vfend);
  • a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), or pentobarbital (Nembutal);
  • heart or blood pressure medication such as amiodarone (Cordarone, Pacerone), diltiazem (Cartia, Cardizem), dofetilide (Tikosyn), disopyramide (Norpace), dronedarone (Multaq), ibutilide (Corvert), nicardipine (Cardene), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quin-G), sotalol (Betapace), verapamil (Calan, Covera, Isoptin, Verelan), and others;
  • medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil);
  • medicine to prevent or treat nausea and vomiting such as dolasetron (Anzemet), droperidol (Inapsine), or ondansetron (Zofran);
  • medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon);
  • migraine headache medicine such as sumatriptan (Imitrex, Treximet) or zolmitriptan (Zomig);
  • narcotic medication such as methadone (Methadose, Diskets, Dolophine); or
  • other HIV medicines such as atazanavir (Reyataz), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, Kaletra), or saquinavir (Invirase).
donotThis list is not complete and there are many other medicines that can interact with rilpivirine, or make it less effective. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about rilpivirine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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