hyoscyamine, methenamine, methylene blue, and sodium biphosphate

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hyoscyamine, methenamine, methylene blue, and sodium biphosphate

Pronunciation:HYE oh SYE a meen, meth EN a meen, METH il een BLUE, FEEN il sa LIS il ate

What is the most important information I should know about hyoscyamine, methenamine, methylene blue, and sodium biphosphate?

donotYou should not use hyoscyamine, methenamine, methylene blue, and sodium biphosphate if you are allergic to it.

Before taking this medication, tell your doctor if you have any type of heart problem (congestive heart failure, coronary heart disease, a heart valve or heart rhythm disorder), glaucoma, an enlarged prostate, bladder obstruction, myasthenia gravis, a stomach ulcer or obstruction, or if you are allergic to belladonna (Donnatal and others).

waterDrink plenty of liquids while you are taking this medication.
emtIf you have an eye exam and your pupils are dilated with eye drops, tell the eye doctor ahead of time that you are using hyoscyamine, methenamine, methylene blue, and sodium biphosphate.

Many drugs can interact with this medicine. Also, hyoscyamine can make it harder for your body to absorb other medications you take by mouth. Tell your doctor about all other medicines you use.

What is hyoscyamine, methenamine, methylene blue, and sodium biphosphate?

Hyoscyamine produces many effects in the body, including relief from muscle spasms.

Methenamine and methylene blue work as mild antiseptics that fight bacteria in the urine and bladder.

Sodium biphosphate is a form of phosphorus, which is a naturally occurring substance that is important in every cell in the body.

The combination of hyoscyamine, methenamine, methylene blue, and sodium biphosphate is used to treat bladder irritation (pain, burning, inflammation) caused by urinary tract infection. This medication is also used to prevent bladder discomfort during a medical procedure.

Hyoscyamine, methenamine, methylene blue, and sodium biphosphate may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking hyoscyamine, methenamine, methylene blue, and sodium biphosphate?

donotYou should not use hyoscyamine, methenamine, methylene blue, and sodium biphosphate if you are allergic to it.

To make sure you can safely take this medication, tell your doctor if you have any of these other conditions:

  • heart disease;
  • a heart rhythm disorder;
  • congestive heart failure;
  • coronary heart disease;
  • a heart valve disorder;
  • glaucoma;
  • an enlarged prostate or bladder obstruction;
  • myasthenia gravis;
  • an ulcer or obstruction in your stomach; or
  • if you are allergic to belladonna (Donnatal and others).
nopregFDA pregnancy category C. It is not known whether this medication will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
nobrfeedHyoscyamine, methenamine, methylene blue, and sodium biphosphate can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
nochildHyoscyamine, methenamine, methylene blue, and sodium biphosphate should not be given to a child younger than 7 years old.

Older adults may be more likely to have side effects from this medication.

How should I take hyoscyamine, methenamine, methylene blue, and sodium biphosphate?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Hyoscyamine, methenamine, methylene blue, and sodium biphosphate is usually taken 4 times daily. Follow your doctor's instructions.

nocrushDo not crush, chew, or break an enteric coated pill. Swallow it whole. The enteric coated pill has a special coating to protect your stomach. Breaking the pill will damage this coating.
waterDrink plenty of liquids while you are taking this medication.
emtIf you have an eye exam and your pupils are dilated with eye drops, tell the eye doctor ahead of time that you are using hyoscyamine, methenamine, methylene blue, and sodium biphosphate.
rtStore at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

emtSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include excitement or seizure (convulsions).

What should I avoid while taking hyoscyamine, methenamine, methylene blue, and sodium biphosphate?

Avoid taking an antacid or anti-diarrhea medicine within 1 hour before or after you take hyoscyamine, methenamine, methylene blue, and sodium biphosphate. Antacids or anti-diarrhea medicine can make it harder for your body to absorb hyoscyamine.

If you also take ketoconazole (Nizoral), wait at least 2 hours after taking it before you take hyoscyamine, methenamine, methylene blue, and sodium biphosphate.

What are the possible side effects of hyoscyamine, methenamine, methylene blue, and sodium biphosphate?

Methylene blue will most likely cause your urine or stools to appear blue or green in color. This is a normal side effect of the medication and will not cause any harm.

emtGet emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
donotStop using this medication and call your doctor at once if you have a serious side effect such as:
  • severe dizziness, blurred vision, fast heart rate;
  • agitation, confusion, feeling restless or excited;
  • painful or difficult urination; or
  • feeling short of breath.

Less serious side effects may include:

  • mild dizziness;
  • dry mouth; or
  • nausea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hyoscyamine, methenamine, methylene blue, and sodium biphosphate?

Many drugs can interact with this medicine. Also, hyoscyamine can make it harder for your body to absorb other medications you take by mouth. Tell your doctor about all other medicines you use, especially:

  • atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm Scop);
  • a diuretic (water pill);
  • bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);
  • glycopyrrolate (Robinul);
  • homatropine (Hycodan, Tussigon);
  • methantheline;
  • neostigmine (Prostigmin) or pyridostigmine (Mestinon);
  • bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare); or
  • an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate);
  • medicines to treat symptoms of Alzheimer's disease such as donepezil (Aricept), galantamine (Razadyne), memantine (Namenda), rivastigmine (Exelon), or tacrine (Cognex);
  • narcotic pain medication such as codeine (Tylenol #3, Cheratuss, Guaiatuss), fentanyl (Actiq, Duragesic), hydrocodone (Lortab, Vicodin, Vicoprofen), hydromorphone (Dilaudid), methadone (Dolophine, Methadose), morphine (Avinza, Kadian, MS Contin, Oramorph), oxycodone (OxyContin, Endocet, Percocet), propoxyphene (Darvocet, Propacet), and others;
  • sodium bicarbonate, potassium citrate (K-Lyte, Urocit-K), sodium citrate and citric acid (Bicitra, Oracit), or sodium citrate and potassium (Citrolith, Polycitra);
  • sulfa drugs (Bactrim, Septra, Sulfatrim, SMX-TMP, and others); or
  • ulcer or irritable bowel medications such as dicyclomine (Bentyl), glycopyrrolate (Robinul), hyoscyamine (Hyomax), mepenzolate (Cantil), or propantheline (Pro Banthine).

This list is not complete and there are many other drugs that can interact with hyoscyamine, methenamine, methylene blue, and sodium biphosphate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about hyoscyamine, methenamine, methylene blue, and sodium biphosphate.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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