aliskiren, amlodipine, and hydrochlorothiazide

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aliskiren, amlodipine, and hydrochlorothiazide

Pronunciation:AL is KYE ren, am LOE de peen, HYE droe klor oh THYE a zide
Brand:Amturnide

Amturnide 150-5-12.5 mg

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Amturnide 300-10-12.5 mg

oval, red, imprinted with UIU, NVR

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Amturnide 300-10-25 mg

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Amturnide 300-5-12.5 mg

oval, pink, imprinted with LIL, NVR

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Amturnide 300-5-25 mg

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What is the most important information I should know about aliskiren, amlodipine, and hydrochlorothiazide?

nopregDo not use this medication if you are pregnant. It could harm the unborn baby. Stop using this medication and tell your doctor right away if you become pregnant.
donotYou should not take this medication if you are allergic to aliskiren (Tekturna, Tekamlo), amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tribenzor, Twynsta), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Vaseretic, Zestoretic, and many others), or sulfa drugs (Bactrim, Septra, Sulfatrim, SMX-TMP, and others).
donotYou should not take aliskiren, amlodipine, and hydrochlorothiazide if you have severe kidney disease or are unable to urinate, or if you are also taking itraconazole (Sporanox) or cyclosporine (Gengraf, Neoral, Sandimmune).

Before you take aliskiren, amlodipine, and hydrochlorothiazide, tell your doctor if you have kidney or liver disease, glaucoma, lupus, asthma, congestive heart failure, angina (chest pain), coronary artery disease, an electrolyte imbalance (such as low potassium or magnesium), a penicillin allergy, if you are on a low-salt diet, or if you have ever had an allergic reaction to a blood pressure medication.

emtYour chest pain may become worse when you first start taking the medicine or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.
finishKeep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

What is aliskiren, amlodipine, and hydrochlorothiazide?

Aliskiren is an anti-hypertensive (blood pressure lowering) medication. It works by decreasing substances in the body that narrow blood vessels and raise blood pressure.

Amlodipine is in a group of drugs called calcium channel blockers. Amlodipine relaxes (widens) blood vessels and improves blood flow.

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

The combination of aliskiren, amlodipine, and hydrochlorothiazide is used to treat high blood pressure (hypertension).

Aliskiren, amlodipine, and hydrochlorothiazide is usually given after other blood pressure medications have been tried without successful treatment of symptoms.

Aliskiren, amlodipine, and hydrochlorothiazide may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking aliskiren, amlodipine, and hydrochlorothiazide?

donotYou should not take this medication if you are allergic to aliskiren (Tekturna, Tekamlo), amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tribenzor, Twynsta), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Vaseretic, Zestoretic, and many others), or sulfa drugs (Bactrim, Septra, Sulfatrim, SMX-TMP, and others).
donotYou should not take aliskiren, amlodipine, and hydrochlorothiazide if you have severe kidney disease or are unable to urinate, or if you are also taking itraconazole (Sporanox) or cyclosporine (Gengraf, Neoral, Sandimmune).

To make sure you can safely take aliskiren, amlodipine, and hydrochlorothiazide, tell your doctor if you have any of these other conditions:

  • kidney disease (or if you are on dialysis);
  • liver disease;
  • congestive heart failure;
  • angina (chest pain);
  • glaucoma;
  • systemic lupus erythematosus (SLE);
  • asthma;
  • coronary artery disease (hardened arteries);
  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
  • if you are allergic to penicillin;
  • if you are on a low-salt diet; or
  • if you have ever had an allergic reaction to a blood pressure medication.
nopregFDA pregnancy category D. Do not use aliskiren, amlodipine, and hydrochlorothiazide if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. This medication can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking aliskiren, amlodipine, and hydrochlorothiazide.
nobrfeedIt is not known whether this medication passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking aliskiren, amlodipine, and hydrochlorothiazide.

How should I take aliskiren, amlodipine, and hydrochlorothiazide?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

emtYour chest pain may become worse when you first start taking the medicine or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.

Aliskiren, amlodipine, and hydrochlorothiazide may be taken with or without food, but take it the same way each time.

While using aliskiren, amlodipine, and hydrochlorothiazide, you may need blood tests at your doctor's office. Your blood pressure will need to be checked often. Visit your doctor regularly.

emtIf you need surgery, tell the surgeon ahead of time that you are using aliskiren, amlodipine, and hydrochlorothiazide.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking aliskiren, amlodipine, and hydrochlorothiazide. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

finishKeep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
rtStore in the original container at room temperature, away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

emtSeek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include rapid heartbeats, severe dizziness, warmth or tingly feeling, and fainting.

What should I avoid while taking aliskiren, amlodipine, and hydrochlorothiazide?

donotDo not use potassium supplements or salt substitutes while you are taking aliskiren, amlodipine, and hydrochlorothiazide, unless your doctor has told you to.
noalcoholDrinking alcohol can further lower your blood pressure and may increase certain side effects of aliskiren, amlodipine, and hydrochlorothiazide.

Avoid taking with foods that are high in fat, which can make it harder for your body to absorb aliskiren, amlodipine, and hydrochlorothiazide.

dizzyAvoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

What are the possible side effects of aliskiren, amlodipine, and hydrochlorothiazide?

emtGet emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
donotStop using aliskiren, amlodipine, and hydrochlorothiazide and call your doctor at once if you have a serious side effect such as:
  • swelling in your hands, ankles, or feet;
  • feeling like you might pass out;
  • vision problems, eye pain, or seeing halos around lights;
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
  • high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling); or
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.

Less serious side effects may include:

  • headache;
  • dizziness; or
  • stuffy nose, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect aliskiren, amlodipine, and hydrochlorothiazide?

Tell your doctor about all other heart or blood pressure medications you are taking.

dizzyBefore using aliskiren, amlodipine, and hydrochlorothiazide, tell your doctor if you regularly use other medicines that can lower blood pressure (such as sedatives, narcotic pain medicine, sleeping pills, and medicine for seizures or anxiety). They can add to the blood pressure lowering effects of aliskiren, amlodipine, and hydrochlorothiazide.

Tell your doctor about all other medicines you use, especially:

  • atorvastatin (Lipitor, Caduet);
  • cholestyramine (Questran) or colestipol (Colestid);
  • furosemide (Lasix);
  • irbesartan (Avapro);
  • lithium (Eskalith, Lithobid);
  • quinidine (Quin-G);
  • simvastatin (Zocor, Simcor, Vytorin, Juvisync);
  • tacrolimus (Prograf);
  • verapamil (Calan, Covera, Isoptin, Verelan);
  • insulin or oral diabetes medication;
  • an oral, nasal, inhaled, or injectable steroid medicine;
  • any other diuretic (water pill);
  • antifungal medication such as fluconazole (Diflucan), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);
  • HIV or AIDS medications such as nelfinavir (Viracept), ritonavir (Norvir, Kaletra), or saquinavir (Invirase); or
  • non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others.

This list is not complete and other drugs may interact with aliskiren, amlodipine, and hydrochlorothiazide. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about aliskiren, amlodipine, and hydrochlorothiazide.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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