mestranol and norethindrone

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mestranol and norethindrone

Pronunciation:MESS tra nol and nor eth IN drone
Brand:Necon 1/50, Norinyl 1+50, Ortho-Novum 1/50

Necon 1-50-28

white, imprinted with WATSON, 245

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Norinyl 1-50

round, white, imprinted with 265, WATSON

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What is the most important information I should know about mestranol and norethindrone?

nopregDo not use birth control pills if you are pregnant or if you have recently had a baby.
donotDo not use this medication if you have any of the following conditions: a history of stroke or blood clot, circulation problems, a hormone-related cancer such as breast or uterine cancer, abnormal vaginal bleeding, liver disease or liver cancer, or a history of jaundice caused by birth control pills.

What is mestranol and norethindrone?

Mestranol and norethindrone contains a combination of female hormones that prevent ovulation (the release of an egg from an ovary). This medication also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.

Mestranol and norethindrone is used as contraception to prevent pregnancy.

Mestranol and norethindrone may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking mestranol and norethindrone?

nopregThis medication can cause birth defects. Do not use if you are pregnant. Tell your doctor right away if you become pregnant, or if you miss two menstrual periods in a row. If you have recently had a baby, wait at least 4 weeks before taking birth control pills (6 weeks if you are breast-feeding).
donotDo not use this medication if you have:
  • a history of a stroke, blood clot, or circulation problems;
  • a hormone-related cancer such as breast or uterine cancer;
  • abnormal vaginal bleeding;
  • liver disease or liver cancer; or
  • a history of jaundice caused by birth control pills.

Before using this medication, tell your doctor if you have any of the following conditions:

  • high blood pressure, heart disease, congestive heart failure, angina (chest pain), or a history of heart attack;
  • high cholesterol or if you are overweight;
  • kidney disease;
  • a history of depression;
  • diabetes;
  • gallbladder disease;
  • seizures or epilepsy;
  • a history of irregular menstrual cycles; or
  • a history of fibrocystic breast disease, lumps, nodules, or an abnormal mammogram.
nobrfeedThe hormones in birth control pills can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast-feeding a baby.

How should I take mestranol and norethindrone?

Take this medication exactly as it was prescribed for you. You will take your first pill on the first day of your period or on the first Sunday after your period begins (follow your doctor's instructions).

You may need to use back-up birth control, such as condoms or a spermicide, when you first start using this medication. Follow your doctor's instructions.

The 28-day birth control pack contains seven "reminder" pills to keep you on your regular cycle. Your period will usually begin while you are using these reminder pills.

emtYou may have breakthrough bleeding, especially during the first 3 months. Tell your doctor if this bleeding continues or is very heavy.

Take one pill every day, no more than 24 hours apart. When the pills run out, start a new pack the following day. Get your prescription refilled before you run out of pills completely.

If you need to have any type of medical tests or surgery, or if you will be on bed rest, you may need to stop using this medication for a short time. Any doctor or surgeon who treats you should know that you are using birth control pills.

rtStore this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Missing a pill increases your risk of becoming pregnant.

If you miss one "active" pill, take two pills on the day that you remember. Then take one pill per day for the rest of the pack.

If you miss two "active" pills in a row in week one or two, take two pills per day for two days in a row. Then take one pill per day for the rest of the pack. Use back-up birth control for at least 7 days following the missed pills.

If you miss two "active" pills in a row in week three, or if you miss three pills in a row during any of the first 3 weeks, throw out the rest of the pack and start a new one the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new one that day.

If you miss three "active" pills in a row during any of the first 3 weeks, throw out the rest of the pack and start a new pack on the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new one that day.

donotIf you miss two or more pills, you may not have a period during the month. If you miss a period for two months in a row, call your doctor because you might be pregnant.

If you miss any reminder pills, throw them away and keep taking one pill per day until the pack is empty. You do not need back-up birth control if you miss a reminder pill.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an overdose may include nausea, vomiting, and vaginal bleeding.

What should I avoid while taking mestranol and norethindrone?

smokingDo not smoke while using birth control pills, especially if you are older than 35. Smoking can increase your risk of blood clots, stroke, or heart attack caused by birth control pills.

Birth control pills will not protect you from sexually transmitted diseases--including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.

What are the possible side effects of mestranol and norethindrone?

emtGet emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
emtStop using this medication and call your doctor at once if you have any of these serious side effects:
  • sudden numbness or weakness, headache, confusion, problems with vision, speech, or balance
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • nausea, stomach pain, dark urine, jaundice (yellowing of the skin or eyes);
  • swelling in your hands, ankles, or feet; o
  • symptoms of depression (sleep problems, weakness, mood changes).

Less serious side effects may include:

  • mild nausea, vomiting, bloating, stomach cramps;
  • breast pain, tenderness, or swelling;
  • darkening of facial skin, increased hair growth, loss of scalp hair;
  • changes in weight or appetite;
  • problems with contact lenses;
  • vaginal itching or discharge;
  • changes in your menstrual periods, decreased sex drive; or
  • headache, nervousness, dizziness, tired feeling.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect mestranol and norethindrone?

Some drugs can make birth control pills less effective, which may result in pregnancy. Before using this medication, tell your doctor if you are using any of the following drugs:

  • phenylbutazone (Azolid, Butazolidin);
  • an antibiotic such as amoxicillin (Augmentin), ampicillin (Omnipen), doxycycline (Doryx, Vibramycin), penicillin, rifampin (Rifadin), tetracycline, and others;
  • seizure medicines such as phenytoin (Dilantin), carbamazepine (Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), topiramate (Topamax), or primidone (Mysoline);
  • a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), phenobarbital (Solfoton), y otros; or
  • HIV medicines.

This list is not complete and there may be other drugs that can affect birth control pills. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about mestranol and norethindrone.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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