Straight Talk about Statins

Tens of millions of Americans take a statin – widely considered the “gold standard” for treating high cholesterol when combined with heart healthy choices like eating right and getting regular exercise.

Beyond their cholesterol-lowering benefits, statins can also help prevent heart attacks and stroke – two leading causes of disability and death.

MORE: What You Need to Know about Statins

Yet, even though statins are one of the most prescribed medications, they are often misunderstood. Our experts help dispel some common misperceptions surrounding their use.


What you
might think
or have read


What the research and clinical experience tells us about taking a statin



I feel great, so why would I need a statin?

Unlike taking an antibiotic to clear an infection that’s had you laid up in bed or a medication to ease a throbbing headache, you won’t “feel” the benefits of a statin. But that doesn’t mean it’s not working as it should. Most statins can cut cholesterol levels in half, But remember, while statins treat cholesterol, it’s really about treating your heart attack and stroke risk.


I’ve heard statins often cause muscles pain and weakness, and I worry that taking one will limit what I can do.

Most people taking a statin – 9 out of 10 – do NOT report muscle aches or weakness. Even among those who do, it is usually mild and can be managed.

The trick is that aches and pains are quite common among the age group of people who stand to benefit from statins. There are many other potential causes including exercise, overexertion, sitting for too long, low vitamin D levels, thyroid problems, and arthritis to name a few. Statins tend to affect the large muscles of the legs and arms, not the joints. So experts say if your knee, hip or shoulder bother you, it’s unlikely related to the statin. The good news is that even if you do develop muscle symptoms thought to be related to your statin, there are others you can try.

Bottom line: If you’re worried about it, ask your health care provider to take a careful history of your aches and pains before you start on a statin. If you are already taking one and begin to have any muscle symptoms, your health care provider can take steps to evaluate and manage them. Many times it’s as easy as changing other medicines or boosting your vitamin D level.


I’ve heard cholesterol is good for my body.

While it’s true that we need some cholesterol for normal cell and body function, too much “bad” cholesterol can spell trouble. Over time, it can lead to a dangerous build up of fat and plaque within the walls of your arteries. If this plaque breaks free or blocks the normal flow of blood, it can cause a heart attack or stroke.

Bottom line: Taking a statins – if your health team recommends one – along with exercise, and a healthy diet, is one of the best ways to treat high cholesterol and manage your risk for cardiovascular disease, heart attack or stroke.


I don’t want to take anything that’s going to affect my memory or ability to think clearly.

There is really no clear evidence that statins cause memory loss or problems with thinking. While the Food and Drug Administration added a safety alert label to statins in 2012, subsequent medical experts including the Statin Safety Task Force have carefully looked at the research to conclude the evidence is weak if not nonexistent, even among people with Alzheimer’s disease.

Among those who have developed memory loss or confusion while taking statins, it seems these side effects reverse once you stop taking the medication.

On the flip side, recent data seem to suggest that statins may actually help ward off dementia. That’s because one of the potential causes of memory loss and altered thinking is dementia due to restricted blood flow to the brain, which statins can help with.

Bottom line: Memory problems from statins seem to be unlikely and, in most cases, it is doubtful that statins are the culprit. The same process that affects the arteries that supply the heart also can affect the arteries of the brain (called atherosclerosis); this is also a common form of dementia (vascular dementia). Talk with your health care provider if you have concerns.


I’ve heard statins cause diabetes, and I know diabetes comes with a host of health concerns, including potential heart disease.

There is a small, potential risk of developing type 2 diabetes as a result of taking a statin; however, experts say this is most often among people who likely would have developed diabetes anyway. For example, they already had borderline blood glucose levels (those nearing diabetes, but not quite) and other risk factors, such as being overweight or being insulin resistant. So while they might develop diabetes a little sooner – data show about one month earlier than they would have off the statin – the benefit of being on a statin becomes even more important because once you have diabetes, you're much more likely to develop cardiovascular disease.

Bottom line: If you are a healthy weight and don’t have other risk factors, it is very unlikely that you would develop diabetes from taking a statin.


Statins damage the liver.

While early research showed a link between statins and liver damage, we now know it is extremely rare. In fact, the FDA no longer recommends routine liver tests after starting statin therapy unless you begin to have signs and symptoms of liver damage. These include: unusual fatigue, loss of appetite, pain in your upper abdomen, dark-colored urine or yellowing of your skin or eyes.

Your doctor may order a blood test to check your liver function before starting you on a statin just to make sure your liver is healthy.

Bottom line: Statins are unlikely to cause any liver injury. The benefit of preventing a stroke or heart attack far outweighs the small chance of any liver problems. If you’ve had any liver problems or have hepatitis, be sure to tell your doctor. In many cases, you can still take a statin, but your liver levels will need to be checked.

Infographic: Cholesterol

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